Motif 157 (n=171)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JLL6 | None | S202 | ochoa | Proline-rich transmembrane protein 2 | None |
| A0A1W2PPC1 | PRR33 | S207 | ochoa | Proline rich 33 | None |
| A6NHQ4 | EPOP | S179 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
| A8MVW0 | FAM171A2 | S737 | ochoa | Protein FAM171A2 | None |
| A8MZF0 | PRR33 | S59 | ochoa | Proline-rich protein 33 | None |
| K7EQG2 | None | S30 | ochoa | Uncharacterized protein | None |
| O00178 | GTPBP1 | S634 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00192 | ARVCF | S203 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00221 | NFKBIE | S183 | ochoa | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O00268 | TAF4 | S109 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
| O14686 | KMT2D | S2251 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15085 | ARHGEF11 | S146 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15164 | TRIM24 | S654 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15516 | CLOCK | S449 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O15530 | PDPK1 | S64 | ochoa|psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43184 | ADAM12 | S830 | ochoa | Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}. |
| O43379 | WDR62 | S1342 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43426 | SYNJ1 | S1080 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43663 | PRC1 | S472 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43683 | BUB1 | S331 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60240 | PLIN1 | S458 | ochoa | Perilipin-1 (Lipid droplet-associated protein) | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
| O60346 | PHLPP1 | S313 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60516 | EIF4EBP3 | S51 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}. |
| O60784 | TOM1 | S462 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75533 | SF3B1 | S242 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75533 | SF3B1 | S344 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75563 | SKAP2 | S101 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75995 | SASH3 | S158 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94885 | SASH1 | S1045 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95429 | BAG4 | S281 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95644 | NFATC1 | S269 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95785 | WIZ | S1121 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P02452 | COL1A1 | S171 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P08651 | NFIC | S464 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P11137 | MAP2 | S1610 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12270 | TPR | S2061 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P16383 | GCFC2 | S19 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P18583 | SON | S1702 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19484 | TFEB | S133 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P23396 | RPS3 | S224 | ochoa|psp | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P25054 | APC | S2302 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25100 | ADRA1D | S492 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P27816 | MAP4 | S742 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | S228 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P32927 | CSF2RB | S667 | ochoa | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P33240 | CSTF2 | S513 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P38159 | RBMX | S91 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P40222 | TXLNA | S515 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P48436 | SOX9 | S228 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48634 | PRRC2A | S823 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S920 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S932 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49795 | RGS19 | S24 | psp | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| P49796 | RGS3 | S806 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50549 | ETV1 | S191 | ochoa|psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
| P52272 | HNRNPM | S29 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52824 | DGKQ | S31 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P54259 | ATN1 | S664 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55196 | AFDN | S1238 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56693 | SOX10 | S232 | psp | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P61978 | HNRNPK | S284 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78310 | CXADR | S323 | ochoa | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
| P78559 | MAP1A | S1837 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78563 | ADARB1 | S216 | psp | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| P85037 | FOXK1 | S441 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q00653 | NFKB2 | S427 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01167 | FOXK2 | S394 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02297 | NRG1 | S435 | ochoa | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}. |
| Q07157 | TJP1 | Y1419 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07889 | SOS1 | S1254 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q08999 | RBL2 | S971 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q10586 | DBP | S156 | ochoa | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Q12770 | SCAP | S838 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q13428 | TCOF1 | S381 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S446 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S734 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S906 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13459 | MYO9B | S1281 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13541 | EIF4EBP1 | S65 | ochoa|psp | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | S65 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13563 | PKD2 | S166 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14160 | SCRIB | S1300 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14676 | MDC1 | S1033 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1786 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14847 | LASP1 | S182 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14934 | NFATC4 | S295 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15052 | ARHGEF6 | S569 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15306 | IRF4 | S177 | psp | Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:29537367, ECO:0000269|PubMed:36662884, ECO:0000269|PubMed:36917008}. |
| Q15654 | TRIP6 | S147 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15654 | TRIP6 | S156 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q1W6H9 | FAM110C | S174 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q2M3G4 | SHROOM1 | S166 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2T9J0 | TYSND1 | S112 | ochoa | Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form] | Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. {ECO:0000269|PubMed:22002062}. |
| Q3KQU3 | MAP7D1 | S89 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q53ET0 | CRTC2 | S489 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q58EX7 | PLEKHG4 | S67 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5JRA6 | MIA3 | S1673 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5VT52 | RPRD2 | S1213 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q63HR2 | TNS2 | S648 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q63HR2 | TNS2 | S830 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66K74 | MAP1S | S651 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68EM7 | ARHGAP17 | S751 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6A1A2 | PDPK2P | S37 | ochoa | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| Q6F5E8 | CARMIL2 | S987 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6NV74 | CRACDL | S640 | ochoa | CRACD-like protein | None |
| Q6NZ67 | MZT2B | S139 | ochoa | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6P582 | MZT2A | S139 | ochoa | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6PKG0 | LARP1 | S291 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UUV7 | CRTC3 | S135 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZVL6 | KIAA1549L | S1588 | ochoa | UPF0606 protein KIAA1549L | None |
| Q6ZW31 | SYDE1 | Y229 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70E73 | RAPH1 | S1224 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7RTP6 | MICAL3 | S1346 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z6L0 | PRRT2 | S202 | ochoa | Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) | As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation. {ECO:0000250|UniProtKB:E9PUL5}. |
| Q7Z7L8 | C11orf96 | S297 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86WR7 | PROSER2 | S235 | ochoa | Proline and serine-rich protein 2 | None |
| Q86X51 | EZHIP | S468 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YD1 | PTOV1 | S34 | ochoa | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
| Q86YV5 | PRAG1 | S135 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IY92 | SLX4 | S1406 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZD0 | SAMD14 | S108 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8N163 | CCAR2 | S23 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N612 | FHIP1B | S514 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8WXD9 | CASKIN1 | S787 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q8WXE0 | CASKIN2 | S705 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q92574 | TSC1 | S584 | ochoa|psp | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92630 | DYRK2 | S40 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q92766 | RREB1 | S1122 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92945 | KHSRP | Y688 | psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q969H4 | CNKSR1 | S305 | ochoa | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | May function as an adapter protein or regulator of Ras signaling pathways. |
| Q969S8 | HDAC10 | S373 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
| Q96L73 | NSD1 | S2374 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N77 | ZNF641 | S191 | ochoa | Zinc finger protein 641 | Transcriptional activator. Activates transcriptional activities of SRE and AP-1. {ECO:0000269|PubMed:16343441}. |
| Q96RN5 | MED15 | S502 | ochoa | Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}. |
| Q99618 | CDCA3 | S31 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99626 | CDX2 | S283 | ochoa|psp | Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}. |
| Q9BR39 | JPH2 | S484 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BVT8 | TMUB1 | S86 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}. |
| Q9BYB0 | SHANK3 | S980 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C0E8 | LNPK | S182 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
| Q9GZU1 | MCOLN1 | Y22 | ochoa | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}. |
| Q9H0X9 | OSBPL5 | S35 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H201 | EPN3 | S370 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H211 | CDT1 | S390 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H3P2 | NELFA | S233 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H5H4 | ZNF768 | S88 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H5H4 | ZNF768 | S116 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H6S3 | EPS8L2 | S570 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H7D0 | DOCK5 | T1808 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H9H5 | MAP6D1 | S100 | ochoa | MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) | May have microtubule-stabilizing activity. {ECO:0000250}. |
| Q9NZT2 | OGFR | S519 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9NZT2 | OGFR | S539 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9NZT2 | OGFR | S579 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9NZT2 | OGFR | S639 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P206 | NHSL3 | S529 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UET6 | FTSJ1 | S258 | ochoa | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}. |
| Q9UHY1 | NRBP1 | S363 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UIF9 | BAZ2A | S1397 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKV3 | ACIN1 | S676 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UMS6 | SYNPO2 | S804 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UQ35 | SRRM2 | S2428 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y219 | JAG2 | S1123 | ochoa | Protein jagged-2 (Jagged2) (hJ2) | Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}. |
| Q9Y2H5 | PLEKHA6 | S247 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y4B5 | MTCL1 | S1536 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y6M5 | SLC30A1 | S199 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| P33240 | CSTF2 | S336 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| Q9H0L4 | CSTF2T | S344 | Sugiyama | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9Y5X1 | SNX9 | S122 | Sugiyama | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q92945 | KHSRP | Y626 | Sugiyama | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q15569 | TESK1 | S355 | Sugiyama | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q9P0L2 | MARK1 | S624 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.002094 | 2.679 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000479 | 3.320 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.001974 | 2.705 |
| R-HSA-9909396 | Circadian clock | 0.001411 | 2.850 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.001814 | 2.741 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.010993 | 1.959 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 0.032621 | 1.487 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 0.043257 | 1.364 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 0.043257 | 1.364 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.005650 | 2.248 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.053778 | 1.269 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-8941237 | Invadopodia formation | 0.053778 | 1.269 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 0.074475 | 1.128 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 0.074475 | 1.128 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.084654 | 1.072 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 0.084654 | 1.072 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.084654 | 1.072 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.084654 | 1.072 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.084654 | 1.072 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.084654 | 1.072 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.017282 | 1.762 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.019118 | 1.719 |
| R-HSA-112412 | SOS-mediated signalling | 0.104679 | 0.980 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.023022 | 1.638 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.023022 | 1.638 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.124268 | 0.906 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.124268 | 0.906 |
| R-HSA-4839744 | Signaling by APC mutants | 0.143432 | 0.843 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.143432 | 0.843 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.143432 | 0.843 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.143432 | 0.843 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.041471 | 1.382 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.152856 | 0.816 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.152856 | 0.816 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.152856 | 0.816 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.162178 | 0.790 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.162178 | 0.790 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.189535 | 0.722 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.198455 | 0.702 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.198455 | 0.702 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.207278 | 0.683 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.207278 | 0.683 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.207278 | 0.683 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.095966 | 1.018 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.233170 | 0.632 |
| R-HSA-167161 | HIV Transcription Initiation | 0.102863 | 0.988 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.102863 | 0.988 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.241612 | 0.617 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.054629 | 1.263 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.249963 | 0.602 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.258221 | 0.588 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.258221 | 0.588 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.009996 | 2.000 |
| R-HSA-72172 | mRNA Splicing | 0.012875 | 1.890 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.305908 | 0.514 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.305908 | 0.514 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.313554 | 0.504 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.313554 | 0.504 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.328596 | 0.483 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.193542 | 0.713 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.335993 | 0.474 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.335993 | 0.474 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.350546 | 0.455 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.350546 | 0.455 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.250110 | 0.602 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.278648 | 0.555 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.278648 | 0.555 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.290867 | 0.536 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.303061 | 0.518 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.307118 | 0.513 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.323298 | 0.490 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.327329 | 0.485 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.241612 | 0.617 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.202671 | 0.693 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.202671 | 0.693 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.331353 | 0.480 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.347382 | 0.459 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.202671 | 0.693 |
| R-HSA-1538133 | G0 and Early G1 | 0.343309 | 0.464 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 0.233170 | 0.632 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.117042 | 0.932 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.023022 | 1.638 |
| R-HSA-156902 | Peptide chain elongation | 0.290867 | 0.536 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.023022 | 1.638 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.124268 | 0.906 |
| R-HSA-191650 | Regulation of gap junction activity | 0.064183 | 1.193 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.074475 | 1.128 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.171397 | 0.766 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.266389 | 0.574 |
| R-HSA-167172 | Transcription of the HIV genome | 0.052941 | 1.276 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.109891 | 0.959 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.290479 | 0.537 |
| R-HSA-165158 | Activation of AKT2 | 0.074475 | 1.128 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.007721 | 2.112 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.124268 | 0.906 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.207278 | 0.683 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.102863 | 0.988 |
| R-HSA-72187 | mRNA 3'-end processing | 0.142914 | 0.845 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.063453 | 1.198 |
| R-HSA-2424491 | DAP12 signaling | 0.328596 | 0.483 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.174950 | 0.757 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.004688 | 2.329 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.174950 | 0.757 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.106361 | 0.973 |
| R-HSA-8851805 | MET activates RAS signaling | 0.162178 | 0.790 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.327329 | 0.485 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.007152 | 2.146 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.025087 | 1.601 |
| R-HSA-74749 | Signal attenuation | 0.133903 | 0.873 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.040374 | 1.394 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.343309 | 0.464 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.274572 | 0.561 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.296474 | 0.528 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.116210 | 0.935 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.017553 | 1.756 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.021866 | 1.660 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.043257 | 1.364 |
| R-HSA-75102 | C6 deamination of adenosine | 0.043257 | 1.364 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.064183 | 1.193 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.064183 | 1.193 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.143432 | 0.843 |
| R-HSA-428540 | Activation of RAC1 | 0.152856 | 0.816 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.152856 | 0.816 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.152856 | 0.816 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.152856 | 0.816 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.162178 | 0.790 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.162178 | 0.790 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.189535 | 0.722 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.189535 | 0.722 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.198455 | 0.702 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.224634 | 0.649 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.249963 | 0.602 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.258221 | 0.588 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.266389 | 0.574 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.282459 | 0.549 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.282459 | 0.549 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.165944 | 0.780 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.305908 | 0.514 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.177690 | 0.750 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.319261 | 0.496 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.102749 | 0.988 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.069886 | 1.156 |
| R-HSA-112399 | IRS-mediated signalling | 0.162060 | 0.790 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.311170 | 0.507 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.189561 | 0.722 |
| R-HSA-9620244 | Long-term potentiation | 0.046721 | 1.330 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.069886 | 1.156 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.224634 | 0.649 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.003669 | 2.435 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.084654 | 1.072 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.044067 | 1.356 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.162178 | 0.790 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.066817 | 1.175 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.189535 | 0.722 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.313554 | 0.504 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.213596 | 0.670 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.007721 | 2.112 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.249963 | 0.602 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.130734 | 0.884 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.189561 | 0.722 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.330052 | 0.481 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003669 | 2.435 |
| R-HSA-75072 | mRNA Editing | 0.124268 | 0.906 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.133903 | 0.873 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.180516 | 0.743 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.305908 | 0.514 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.313554 | 0.504 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.177690 | 0.750 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.328596 | 0.483 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.225723 | 0.646 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.311170 | 0.507 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.069886 | 1.156 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.082605 | 1.083 |
| R-HSA-68877 | Mitotic Prometaphase | 0.208634 | 0.681 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.272557 | 0.565 |
| R-HSA-162587 | HIV Life Cycle | 0.130222 | 0.885 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.193542 | 0.713 |
| R-HSA-9843745 | Adipogenesis | 0.222649 | 0.652 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.308485 | 0.511 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.162178 | 0.790 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.162178 | 0.790 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.060820 | 1.216 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.189535 | 0.722 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.189535 | 0.722 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.241612 | 0.617 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.305908 | 0.514 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.181634 | 0.741 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.328596 | 0.483 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.351370 | 0.454 |
| R-HSA-416476 | G alpha (q) signalling events | 0.207307 | 0.683 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.299474 | 0.524 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.173760 | 0.760 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.016632 | 1.779 |
| R-HSA-5689603 | UCH proteinases | 0.067157 | 1.173 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.015806 | 1.801 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.224634 | 0.649 |
| R-HSA-9610379 | HCMV Late Events | 0.305480 | 0.515 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.021518 | 1.667 |
| R-HSA-8953854 | Metabolism of RNA | 0.053381 | 1.273 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.013852 | 1.858 |
| R-HSA-390696 | Adrenoceptors | 0.114527 | 0.941 |
| R-HSA-444257 | RSK activation | 0.114527 | 0.941 |
| R-HSA-2214320 | Anchoring fibril formation | 0.152856 | 0.816 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.162178 | 0.790 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.189535 | 0.722 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.198455 | 0.702 |
| R-HSA-9945266 | Differentiation of T cells | 0.198455 | 0.702 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.207278 | 0.683 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.258221 | 0.588 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.266389 | 0.574 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.274468 | 0.562 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.335993 | 0.474 |
| R-HSA-162906 | HIV Infection | 0.292131 | 0.534 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.063453 | 1.198 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.063453 | 1.198 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.006981 | 2.156 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.216004 | 0.666 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.216004 | 0.666 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.233170 | 0.632 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.258221 | 0.588 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.266389 | 0.574 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.290361 | 0.537 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.313554 | 0.504 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.116210 | 0.935 |
| R-HSA-9671793 | Diseases of hemostasis | 0.233170 | 0.632 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.013225 | 1.879 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.015738 | 1.803 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.074475 | 1.128 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.084654 | 1.072 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.084654 | 1.072 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.019118 | 1.719 |
| R-HSA-448706 | Interleukin-1 processing | 0.124268 | 0.906 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.180516 | 0.743 |
| R-HSA-167044 | Signalling to RAS | 0.249963 | 0.602 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.266389 | 0.574 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.298178 | 0.526 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.216899 | 0.664 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.298178 | 0.526 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.298178 | 0.526 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.173760 | 0.760 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.173760 | 0.760 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.173760 | 0.760 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.173760 | 0.760 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.130734 | 0.884 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.207278 | 0.683 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.224634 | 0.649 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.266389 | 0.574 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.181634 | 0.741 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.012442 | 1.905 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.015806 | 1.801 |
| R-HSA-449836 | Other interleukin signaling | 0.233170 | 0.632 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.249963 | 0.602 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.249963 | 0.602 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.321116 | 0.493 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.328596 | 0.483 |
| R-HSA-165159 | MTOR signalling | 0.106361 | 0.973 |
| R-HSA-3371556 | Cellular response to heat stress | 0.188677 | 0.724 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.158878 | 0.799 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.227059 | 0.644 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.069886 | 1.156 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.207278 | 0.683 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.258221 | 0.588 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.350546 | 0.455 |
| R-HSA-380287 | Centrosome maturation | 0.233836 | 0.631 |
| R-HSA-9707616 | Heme signaling | 0.007938 | 2.100 |
| R-HSA-195721 | Signaling by WNT | 0.276487 | 0.558 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.290361 | 0.537 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.089203 | 1.050 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.091341 | 1.039 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.254185 | 0.595 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.324158 | 0.489 |
| R-HSA-69206 | G1/S Transition | 0.202671 | 0.693 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.350589 | 0.455 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.074475 | 1.128 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.104679 | 0.980 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.189535 | 0.722 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.034736 | 1.459 |
| R-HSA-210993 | Tie2 Signaling | 0.224634 | 0.649 |
| R-HSA-3295583 | TRP channels | 0.298178 | 0.526 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.313554 | 0.504 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.180407 | 0.744 |
| R-HSA-6806834 | Signaling by MET | 0.254185 | 0.595 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.058083 | 1.236 |
| R-HSA-190236 | Signaling by FGFR | 0.339382 | 0.469 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.180516 | 0.743 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.237900 | 0.624 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.180516 | 0.743 |
| R-HSA-8853659 | RET signaling | 0.082605 | 1.083 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.290361 | 0.537 |
| R-HSA-186763 | Downstream signal transduction | 0.335993 | 0.474 |
| R-HSA-177929 | Signaling by EGFR | 0.158193 | 0.801 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.129477 | 0.888 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.141817 | 0.848 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.021518 | 1.667 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.207278 | 0.683 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.274468 | 0.562 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.298178 | 0.526 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.139486 | 0.855 |
| R-HSA-74160 | Gene expression (Transcription) | 0.030674 | 1.513 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.152032 | 0.818 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.258221 | 0.588 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.305908 | 0.514 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.270178 | 0.568 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.114527 | 0.941 |
| R-HSA-9842663 | Signaling by LTK | 0.162178 | 0.790 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.231818 | 0.635 |
| R-HSA-162582 | Signal Transduction | 0.049323 | 1.307 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.305908 | 0.514 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.036463 | 1.438 |
| R-HSA-4839726 | Chromatin organization | 0.178851 | 0.748 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.055021 | 1.259 |
| R-HSA-354192 | Integrin signaling | 0.069886 | 1.156 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.282459 | 0.549 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.290361 | 0.537 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.092501 | 1.034 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.321116 | 0.493 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.008937 | 2.049 |
| R-HSA-435354 | Zinc transporters | 0.180516 | 0.743 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.266389 | 0.574 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.222063 | 0.654 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.117686 | 0.929 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.298178 | 0.526 |
| R-HSA-72306 | tRNA processing | 0.347585 | 0.459 |
| R-HSA-3000170 | Syndecan interactions | 0.274468 | 0.562 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.145858 | 0.836 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.082605 | 1.083 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.127980 | 0.893 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.350546 | 0.455 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.162178 | 0.790 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.061638 | 1.210 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.145858 | 0.836 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.233170 | 0.632 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.284493 | 0.546 |
| R-HSA-75153 | Apoptotic execution phase | 0.022580 | 1.646 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.136052 | 0.866 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.044783 | 1.349 |
| R-HSA-212436 | Generic Transcription Pathway | 0.149743 | 0.825 |
| R-HSA-1500931 | Cell-Cell communication | 0.314909 | 0.502 |
| R-HSA-8848021 | Signaling by PTK6 | 0.185592 | 0.731 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.185592 | 0.731 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.183152 | 0.737 |
| R-HSA-622312 | Inflammasomes | 0.313554 | 0.504 |
| R-HSA-2028269 | Signaling by Hippo | 0.216004 | 0.666 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.241967 | 0.616 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.258261 | 0.588 |
| R-HSA-73887 | Death Receptor Signaling | 0.124500 | 0.905 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.343386 | 0.464 |
| R-HSA-109581 | Apoptosis | 0.320515 | 0.494 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.123393 | 0.909 |
| R-HSA-1483255 | PI Metabolism | 0.355350 | 0.449 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.357703 | 0.446 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.357703 | 0.446 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.357703 | 0.446 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.357703 | 0.446 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.357703 | 0.446 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.357703 | 0.446 |
| R-HSA-192823 | Viral mRNA Translation | 0.359321 | 0.445 |
| R-HSA-5688426 | Deubiquitination | 0.361757 | 0.442 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.363283 | 0.440 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.364781 | 0.438 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.364781 | 0.438 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.364781 | 0.438 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.364781 | 0.438 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.364781 | 0.438 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.367236 | 0.435 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.367236 | 0.435 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.371449 | 0.430 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.371782 | 0.430 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.371782 | 0.430 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.371782 | 0.430 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.371782 | 0.430 |
| R-HSA-381042 | PERK regulates gene expression | 0.371782 | 0.430 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.371782 | 0.430 |
| R-HSA-187687 | Signalling to ERKs | 0.371782 | 0.430 |
| R-HSA-168255 | Influenza Infection | 0.374555 | 0.426 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.375114 | 0.426 |
| R-HSA-163560 | Triglyceride catabolism | 0.378706 | 0.422 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.378706 | 0.422 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.378706 | 0.422 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.378706 | 0.422 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.378706 | 0.422 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.379038 | 0.421 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.382952 | 0.417 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.382952 | 0.417 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.385554 | 0.414 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.385554 | 0.414 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.385554 | 0.414 |
| R-HSA-8948216 | Collagen chain trimerization | 0.385554 | 0.414 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.386479 | 0.413 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.386738 | 0.413 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.386855 | 0.412 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.392327 | 0.406 |
| R-HSA-8875878 | MET promotes cell motility | 0.392327 | 0.406 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.392327 | 0.406 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.398500 | 0.400 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.398500 | 0.400 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.399026 | 0.399 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.399026 | 0.399 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.399026 | 0.399 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.399026 | 0.399 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.399026 | 0.399 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.402503 | 0.395 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.405652 | 0.392 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.405652 | 0.392 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.405652 | 0.392 |
| R-HSA-167169 | HIV Transcription Elongation | 0.405652 | 0.392 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.405652 | 0.392 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.405652 | 0.392 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.405652 | 0.392 |
| R-HSA-5260271 | Diseases of Immune System | 0.405652 | 0.392 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.405652 | 0.392 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.406207 | 0.391 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.412205 | 0.385 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.412205 | 0.385 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.412205 | 0.385 |
| R-HSA-9607240 | FLT3 Signaling | 0.412205 | 0.385 |
| R-HSA-1640170 | Cell Cycle | 0.415749 | 0.381 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.417678 | 0.379 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.417678 | 0.379 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.417678 | 0.379 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.418686 | 0.378 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.418686 | 0.378 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.418686 | 0.378 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.418686 | 0.378 |
| R-HSA-446728 | Cell junction organization | 0.418950 | 0.378 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.425096 | 0.372 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.425263 | 0.371 |
| R-HSA-5693538 | Homology Directed Repair | 0.429036 | 0.368 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.431435 | 0.365 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.431435 | 0.365 |
| R-HSA-8854214 | TBC/RABGAPs | 0.431435 | 0.365 |
| R-HSA-2172127 | DAP12 interactions | 0.437706 | 0.359 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.437706 | 0.359 |
| R-HSA-69236 | G1 Phase | 0.437706 | 0.359 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.437706 | 0.359 |
| R-HSA-5683826 | Surfactant metabolism | 0.437706 | 0.359 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.437706 | 0.359 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.440279 | 0.356 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.443907 | 0.353 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.443907 | 0.353 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.443907 | 0.353 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.443907 | 0.353 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.443907 | 0.353 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.445136 | 0.352 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.447706 | 0.349 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.450040 | 0.347 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.450040 | 0.347 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.450040 | 0.347 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.450040 | 0.347 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.450040 | 0.347 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.450040 | 0.347 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.450040 | 0.347 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.450040 | 0.347 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.450040 | 0.347 |
| R-HSA-5357801 | Programmed Cell Death | 0.453758 | 0.343 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.456107 | 0.341 |
| R-HSA-194138 | Signaling by VEGF | 0.458744 | 0.338 |
| R-HSA-68886 | M Phase | 0.460373 | 0.337 |
| R-HSA-1483257 | Phospholipid metabolism | 0.460498 | 0.337 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.462106 | 0.335 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.462106 | 0.335 |
| R-HSA-425410 | Metal ion SLC transporters | 0.462106 | 0.335 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.468040 | 0.330 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.468040 | 0.330 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.473656 | 0.325 |
| R-HSA-109704 | PI3K Cascade | 0.473909 | 0.324 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.473909 | 0.324 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.479713 | 0.319 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.485453 | 0.314 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.485453 | 0.314 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.485453 | 0.314 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.485453 | 0.314 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.491131 | 0.309 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.491131 | 0.309 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.491131 | 0.309 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.491131 | 0.309 |
| R-HSA-72649 | Translation initiation complex formation | 0.496746 | 0.304 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.496746 | 0.304 |
| R-HSA-9675108 | Nervous system development | 0.501324 | 0.300 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.502300 | 0.299 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.502300 | 0.299 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.502300 | 0.299 |
| R-HSA-418597 | G alpha (z) signalling events | 0.502300 | 0.299 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.505057 | 0.297 |
| R-HSA-9824446 | Viral Infection Pathways | 0.505287 | 0.296 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.507793 | 0.294 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.507793 | 0.294 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.507793 | 0.294 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.507793 | 0.294 |
| R-HSA-75893 | TNF signaling | 0.507793 | 0.294 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.511953 | 0.291 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.512428 | 0.290 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.513225 | 0.290 |
| R-HSA-1483166 | Synthesis of PA | 0.513225 | 0.290 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.513225 | 0.290 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.518598 | 0.285 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.523912 | 0.281 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.523912 | 0.281 |
| R-HSA-9033241 | Peroxisomal protein import | 0.523912 | 0.281 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.523912 | 0.281 |
| R-HSA-191859 | snRNP Assembly | 0.523912 | 0.281 |
| R-HSA-8979227 | Triglyceride metabolism | 0.523912 | 0.281 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.528918 | 0.277 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.529167 | 0.276 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.529167 | 0.276 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.532263 | 0.274 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.534365 | 0.272 |
| R-HSA-1442490 | Collagen degradation | 0.534365 | 0.272 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.539506 | 0.268 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.539506 | 0.268 |
| R-HSA-186797 | Signaling by PDGF | 0.539506 | 0.268 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.541818 | 0.266 |
| R-HSA-373755 | Semaphorin interactions | 0.544590 | 0.264 |
| R-HSA-69242 | S Phase | 0.548745 | 0.261 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.549619 | 0.260 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.559511 | 0.252 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.559511 | 0.252 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.561636 | 0.251 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.564376 | 0.248 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.564376 | 0.248 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.564818 | 0.248 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.569187 | 0.245 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.569187 | 0.245 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.569187 | 0.245 |
| R-HSA-1989781 | PPARA activates gene expression | 0.571132 | 0.243 |
| R-HSA-449147 | Signaling by Interleukins | 0.574464 | 0.241 |
| R-HSA-9609646 | HCMV Infection | 0.575212 | 0.240 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.577380 | 0.239 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.578651 | 0.238 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.578651 | 0.238 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.578651 | 0.238 |
| R-HSA-9711097 | Cellular response to starvation | 0.580480 | 0.236 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.583306 | 0.234 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.583306 | 0.234 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.583306 | 0.234 |
| R-HSA-3000178 | ECM proteoglycans | 0.583306 | 0.234 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.583306 | 0.234 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.583306 | 0.234 |
| R-HSA-877300 | Interferon gamma signaling | 0.583562 | 0.234 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.587909 | 0.231 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.587909 | 0.231 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.587909 | 0.231 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.587909 | 0.231 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.592462 | 0.227 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.592462 | 0.227 |
| R-HSA-4086398 | Ca2+ pathway | 0.592462 | 0.227 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.595000 | 0.225 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.596965 | 0.224 |
| R-HSA-422475 | Axon guidance | 0.598041 | 0.223 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.598726 | 0.223 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.598726 | 0.223 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.601418 | 0.221 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.601418 | 0.221 |
| R-HSA-917937 | Iron uptake and transport | 0.601418 | 0.221 |
| R-HSA-1266738 | Developmental Biology | 0.602571 | 0.220 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.607063 | 0.217 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.613517 | 0.212 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.614486 | 0.211 |
| R-HSA-4086400 | PCP/CE pathway | 0.614486 | 0.211 |
| R-HSA-216083 | Integrin cell surface interactions | 0.614486 | 0.211 |
| R-HSA-9679506 | SARS-CoV Infections | 0.615071 | 0.211 |
| R-HSA-9659379 | Sensory processing of sound | 0.618747 | 0.208 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.618747 | 0.208 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.619256 | 0.208 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.622961 | 0.206 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.622961 | 0.206 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.627128 | 0.203 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.631250 | 0.200 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.633423 | 0.198 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.635326 | 0.197 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.639358 | 0.194 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.643345 | 0.192 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.651189 | 0.186 |
| R-HSA-388396 | GPCR downstream signalling | 0.656237 | 0.183 |
| R-HSA-69275 | G2/M Transition | 0.663144 | 0.178 |
| R-HSA-202424 | Downstream TCR signaling | 0.666365 | 0.176 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.668337 | 0.175 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.668337 | 0.175 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.678528 | 0.168 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.680885 | 0.167 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.680885 | 0.167 |
| R-HSA-1474290 | Collagen formation | 0.684415 | 0.165 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.687907 | 0.162 |
| R-HSA-9609690 | HCMV Early Events | 0.688465 | 0.162 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.691360 | 0.160 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.701494 | 0.154 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.701494 | 0.154 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.701494 | 0.154 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.701494 | 0.154 |
| R-HSA-3214847 | HATs acetylate histones | 0.704798 | 0.152 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.705249 | 0.152 |
| R-HSA-70171 | Glycolysis | 0.708065 | 0.150 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.711297 | 0.148 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.711297 | 0.148 |
| R-HSA-2262752 | Cellular responses to stress | 0.717913 | 0.144 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.720779 | 0.142 |
| R-HSA-9833110 | RSV-host interactions | 0.723871 | 0.140 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.726928 | 0.139 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.726928 | 0.139 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.727390 | 0.138 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.732847 | 0.135 |
| R-HSA-69239 | Synthesis of DNA | 0.732943 | 0.135 |
| R-HSA-211000 | Gene Silencing by RNA | 0.732943 | 0.135 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.735900 | 0.133 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.735900 | 0.133 |
| R-HSA-68882 | Mitotic Anaphase | 0.736570 | 0.133 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.738696 | 0.132 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.738825 | 0.131 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.738825 | 0.131 |
| R-HSA-418990 | Adherens junctions interactions | 0.740807 | 0.130 |
| R-HSA-202403 | TCR signaling | 0.741718 | 0.130 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.741718 | 0.130 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.741718 | 0.130 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.747408 | 0.126 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.748222 | 0.126 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.750207 | 0.125 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.752974 | 0.123 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.755711 | 0.122 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.758418 | 0.120 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.758418 | 0.120 |
| R-HSA-372790 | Signaling by GPCR | 0.759487 | 0.119 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.763086 | 0.117 |
| R-HSA-70326 | Glucose metabolism | 0.766360 | 0.116 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.766360 | 0.116 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.766360 | 0.116 |
| R-HSA-72312 | rRNA processing | 0.768868 | 0.114 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.771511 | 0.113 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.771511 | 0.113 |
| R-HSA-68875 | Mitotic Prophase | 0.774043 | 0.111 |
| R-HSA-8939211 | ESR-mediated signaling | 0.778235 | 0.109 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.779025 | 0.108 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.779025 | 0.108 |
| R-HSA-157118 | Signaling by NOTCH | 0.783695 | 0.106 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.783898 | 0.106 |
| R-HSA-1643685 | Disease | 0.784262 | 0.106 |
| R-HSA-109582 | Hemostasis | 0.790782 | 0.102 |
| R-HSA-112316 | Neuronal System | 0.791713 | 0.101 |
| R-HSA-73894 | DNA Repair | 0.793287 | 0.101 |
| R-HSA-114608 | Platelet degranulation | 0.793325 | 0.101 |
| R-HSA-69481 | G2/M Checkpoints | 0.793325 | 0.101 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.795617 | 0.099 |
| R-HSA-421270 | Cell-cell junction organization | 0.802722 | 0.095 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.806704 | 0.093 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.808849 | 0.092 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.810872 | 0.091 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.817193 | 0.088 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.819222 | 0.087 |
| R-HSA-6807070 | PTEN Regulation | 0.823212 | 0.084 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.823212 | 0.084 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.825175 | 0.083 |
| R-HSA-9664407 | Parasite infection | 0.825175 | 0.083 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.825175 | 0.083 |
| R-HSA-913531 | Interferon Signaling | 0.826109 | 0.083 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.827116 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 0.827116 | 0.082 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.834667 | 0.078 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.840114 | 0.076 |
| R-HSA-166520 | Signaling by NTRKs | 0.841889 | 0.075 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.841889 | 0.075 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.845382 | 0.073 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.845382 | 0.073 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.847293 | 0.072 |
| R-HSA-9658195 | Leishmania infection | 0.847293 | 0.072 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.848799 | 0.071 |
| R-HSA-9609507 | Protein localization | 0.850478 | 0.070 |
| R-HSA-69306 | DNA Replication | 0.850478 | 0.070 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.852140 | 0.069 |
| R-HSA-9612973 | Autophagy | 0.855407 | 0.068 |
| R-HSA-5663205 | Infectious disease | 0.860609 | 0.065 |
| R-HSA-199991 | Membrane Trafficking | 0.865559 | 0.063 |
| R-HSA-5619102 | SLC transporter disorders | 0.872137 | 0.059 |
| R-HSA-72766 | Translation | 0.876738 | 0.057 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.880436 | 0.055 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.883082 | 0.054 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.884382 | 0.053 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.900006 | 0.046 |
| R-HSA-983712 | Ion channel transport | 0.901153 | 0.045 |
| R-HSA-1474244 | Extracellular matrix organization | 0.901738 | 0.045 |
| R-HSA-5617833 | Cilium Assembly | 0.902253 | 0.045 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.903342 | 0.044 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.908607 | 0.042 |
| R-HSA-1280218 | Adaptive Immune System | 0.908779 | 0.042 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.912613 | 0.040 |
| R-HSA-428157 | Sphingolipid metabolism | 0.913586 | 0.039 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.914549 | 0.039 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.922272 | 0.035 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.949010 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 0.951533 | 0.022 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.965609 | 0.015 |
| R-HSA-6798695 | Neutrophil degranulation | 0.969814 | 0.013 |
| R-HSA-8957322 | Metabolism of steroids | 0.978586 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.988208 | 0.005 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.989141 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990414 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.990735 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993025 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.993411 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.993776 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.993808 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995209 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996499 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.998737 | 0.001 |
| R-HSA-168256 | Immune System | 0.998841 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998966 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999862 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.860 | 0.407 | 1 | 0.834 |
HIPK4 |
0.850 | 0.429 | 1 | 0.834 |
SRPK1 |
0.847 | 0.298 | -3 | 0.813 |
HIPK2 |
0.845 | 0.385 | 1 | 0.753 |
DYRK2 |
0.839 | 0.341 | 1 | 0.805 |
KIS |
0.839 | 0.276 | 1 | 0.787 |
CLK2 |
0.839 | 0.310 | -3 | 0.792 |
COT |
0.838 | 0.182 | 2 | 0.871 |
PIM3 |
0.837 | 0.249 | -3 | 0.858 |
CDKL5 |
0.835 | 0.294 | -3 | 0.842 |
NDR2 |
0.834 | 0.232 | -3 | 0.837 |
CDK18 |
0.834 | 0.329 | 1 | 0.732 |
SRPK2 |
0.832 | 0.254 | -3 | 0.746 |
ICK |
0.831 | 0.343 | -3 | 0.869 |
HIPK1 |
0.831 | 0.340 | 1 | 0.818 |
CDKL1 |
0.831 | 0.261 | -3 | 0.849 |
CDK19 |
0.831 | 0.289 | 1 | 0.733 |
CDK1 |
0.830 | 0.293 | 1 | 0.740 |
MTOR |
0.829 | 0.156 | 1 | 0.760 |
CDK5 |
0.829 | 0.317 | 1 | 0.789 |
CDC7 |
0.828 | 0.148 | 1 | 0.780 |
CDK8 |
0.828 | 0.268 | 1 | 0.756 |
MOS |
0.827 | 0.227 | 1 | 0.815 |
MAK |
0.827 | 0.424 | -2 | 0.876 |
NLK |
0.826 | 0.233 | 1 | 0.841 |
ERK5 |
0.825 | 0.205 | 1 | 0.824 |
PIM1 |
0.825 | 0.199 | -3 | 0.818 |
CDK7 |
0.825 | 0.266 | 1 | 0.777 |
DYRK4 |
0.824 | 0.306 | 1 | 0.754 |
JNK2 |
0.824 | 0.290 | 1 | 0.732 |
CDK3 |
0.824 | 0.280 | 1 | 0.703 |
ERK1 |
0.823 | 0.297 | 1 | 0.746 |
SRPK3 |
0.823 | 0.210 | -3 | 0.792 |
P38G |
0.822 | 0.281 | 1 | 0.680 |
CDK13 |
0.822 | 0.246 | 1 | 0.761 |
RSK2 |
0.822 | 0.154 | -3 | 0.810 |
AURC |
0.822 | 0.157 | -2 | 0.634 |
PRKD1 |
0.821 | 0.154 | -3 | 0.842 |
P38B |
0.821 | 0.318 | 1 | 0.747 |
P38A |
0.821 | 0.314 | 1 | 0.799 |
GRK1 |
0.820 | 0.200 | -2 | 0.764 |
CDK12 |
0.819 | 0.253 | 1 | 0.737 |
CDK17 |
0.819 | 0.277 | 1 | 0.684 |
CLK4 |
0.819 | 0.201 | -3 | 0.805 |
JNK3 |
0.818 | 0.261 | 1 | 0.757 |
DYRK1A |
0.818 | 0.297 | 1 | 0.807 |
SKMLCK |
0.818 | 0.161 | -2 | 0.834 |
CDK10 |
0.818 | 0.288 | 1 | 0.752 |
P38D |
0.818 | 0.298 | 1 | 0.710 |
P90RSK |
0.818 | 0.148 | -3 | 0.821 |
PRPK |
0.817 | 0.059 | -1 | 0.810 |
CLK1 |
0.817 | 0.209 | -3 | 0.777 |
PRKD2 |
0.816 | 0.126 | -3 | 0.792 |
NDR1 |
0.816 | 0.099 | -3 | 0.835 |
RSK3 |
0.816 | 0.131 | -3 | 0.810 |
CHAK2 |
0.815 | 0.117 | -1 | 0.786 |
RSK4 |
0.815 | 0.186 | -3 | 0.782 |
ATR |
0.815 | 0.060 | 1 | 0.746 |
IKKB |
0.814 | -0.017 | -2 | 0.685 |
HIPK3 |
0.814 | 0.287 | 1 | 0.802 |
DYRK3 |
0.813 | 0.256 | 1 | 0.815 |
PKCD |
0.813 | 0.150 | 2 | 0.794 |
CDK14 |
0.813 | 0.276 | 1 | 0.759 |
RAF1 |
0.813 | -0.026 | 1 | 0.747 |
GCN2 |
0.813 | -0.050 | 2 | 0.803 |
CDK9 |
0.812 | 0.220 | 1 | 0.768 |
MST4 |
0.812 | 0.085 | 2 | 0.872 |
NEK6 |
0.812 | 0.051 | -2 | 0.796 |
PKACB |
0.811 | 0.141 | -2 | 0.642 |
DYRK1B |
0.811 | 0.261 | 1 | 0.762 |
PKCA |
0.811 | 0.186 | 2 | 0.751 |
CDK16 |
0.810 | 0.269 | 1 | 0.703 |
TBK1 |
0.810 | -0.000 | 1 | 0.637 |
MOK |
0.810 | 0.345 | 1 | 0.830 |
GRK7 |
0.810 | 0.176 | 1 | 0.697 |
CAMK1B |
0.810 | 0.033 | -3 | 0.869 |
PKN3 |
0.810 | 0.083 | -3 | 0.843 |
PKCB |
0.810 | 0.150 | 2 | 0.757 |
NUAK2 |
0.809 | 0.076 | -3 | 0.849 |
DSTYK |
0.809 | -0.047 | 2 | 0.897 |
MLK3 |
0.809 | 0.143 | 2 | 0.761 |
PRKX |
0.808 | 0.150 | -3 | 0.710 |
PKACG |
0.808 | 0.083 | -2 | 0.707 |
LATS2 |
0.808 | 0.078 | -5 | 0.659 |
BMPR2 |
0.808 | -0.021 | -2 | 0.829 |
NIK |
0.808 | 0.074 | -3 | 0.867 |
MLK2 |
0.808 | 0.163 | 2 | 0.821 |
WNK1 |
0.808 | 0.035 | -2 | 0.850 |
PDHK4 |
0.808 | -0.142 | 1 | 0.770 |
TGFBR2 |
0.807 | 0.018 | -2 | 0.760 |
IKKA |
0.807 | 0.059 | -2 | 0.685 |
P70S6KB |
0.806 | 0.086 | -3 | 0.816 |
MLK1 |
0.806 | 0.023 | 2 | 0.824 |
PKCZ |
0.806 | 0.151 | 2 | 0.796 |
PKCG |
0.806 | 0.128 | 2 | 0.756 |
BMPR1B |
0.806 | 0.111 | 1 | 0.728 |
GRK5 |
0.805 | -0.022 | -3 | 0.848 |
CAMLCK |
0.805 | 0.063 | -2 | 0.806 |
ULK2 |
0.805 | -0.061 | 2 | 0.766 |
LATS1 |
0.804 | 0.173 | -3 | 0.838 |
MPSK1 |
0.804 | 0.310 | 1 | 0.774 |
PKN2 |
0.804 | 0.059 | -3 | 0.837 |
IKKE |
0.804 | -0.054 | 1 | 0.629 |
MAPKAPK2 |
0.804 | 0.093 | -3 | 0.764 |
AKT2 |
0.804 | 0.141 | -3 | 0.742 |
PRP4 |
0.803 | 0.219 | -3 | 0.823 |
DAPK2 |
0.803 | 0.070 | -3 | 0.870 |
CAMK2D |
0.803 | 0.039 | -3 | 0.840 |
PAK1 |
0.802 | 0.069 | -2 | 0.762 |
AMPKA1 |
0.802 | 0.051 | -3 | 0.848 |
ERK2 |
0.802 | 0.202 | 1 | 0.770 |
IRE1 |
0.801 | 0.055 | 1 | 0.725 |
MAPKAPK3 |
0.801 | 0.048 | -3 | 0.791 |
PIM2 |
0.801 | 0.152 | -3 | 0.783 |
MARK4 |
0.801 | 0.021 | 4 | 0.779 |
MNK1 |
0.801 | 0.100 | -2 | 0.750 |
CAMK2A |
0.800 | 0.092 | 2 | 0.798 |
RIPK3 |
0.800 | -0.043 | 3 | 0.703 |
MSK2 |
0.799 | 0.069 | -3 | 0.800 |
MNK2 |
0.799 | 0.078 | -2 | 0.746 |
AMPKA2 |
0.799 | 0.073 | -3 | 0.821 |
CAMK2G |
0.799 | -0.106 | 2 | 0.791 |
PDHK1 |
0.799 | -0.137 | 1 | 0.750 |
CDK6 |
0.799 | 0.253 | 1 | 0.750 |
ERK7 |
0.798 | 0.200 | 2 | 0.648 |
NEK9 |
0.798 | -0.013 | 2 | 0.841 |
NEK7 |
0.798 | -0.123 | -3 | 0.821 |
CDK2 |
0.798 | 0.137 | 1 | 0.774 |
PKR |
0.798 | 0.122 | 1 | 0.757 |
MSK1 |
0.797 | 0.092 | -3 | 0.793 |
MASTL |
0.797 | -0.086 | -2 | 0.762 |
AURB |
0.796 | 0.062 | -2 | 0.625 |
SGK3 |
0.796 | 0.119 | -3 | 0.787 |
CDK4 |
0.795 | 0.248 | 1 | 0.729 |
JNK1 |
0.795 | 0.211 | 1 | 0.719 |
DLK |
0.795 | -0.043 | 1 | 0.717 |
CAMK2B |
0.795 | 0.035 | 2 | 0.772 |
PAK3 |
0.795 | 0.020 | -2 | 0.747 |
PRKD3 |
0.795 | 0.062 | -3 | 0.779 |
HUNK |
0.795 | -0.111 | 2 | 0.798 |
PHKG1 |
0.795 | 0.058 | -3 | 0.829 |
BCKDK |
0.794 | -0.098 | -1 | 0.734 |
TSSK1 |
0.794 | 0.024 | -3 | 0.861 |
GSK3A |
0.794 | 0.133 | 4 | 0.503 |
MLK4 |
0.793 | 0.052 | 2 | 0.739 |
PKG2 |
0.793 | 0.078 | -2 | 0.646 |
GRK6 |
0.793 | -0.067 | 1 | 0.732 |
PKCH |
0.793 | 0.071 | 2 | 0.729 |
IRE2 |
0.792 | 0.035 | 2 | 0.723 |
QSK |
0.792 | 0.053 | 4 | 0.753 |
YSK4 |
0.792 | 0.016 | 1 | 0.680 |
TGFBR1 |
0.792 | 0.027 | -2 | 0.772 |
ULK1 |
0.791 | -0.136 | -3 | 0.792 |
NIM1 |
0.791 | -0.024 | 3 | 0.743 |
ALK4 |
0.790 | -0.012 | -2 | 0.793 |
CHAK1 |
0.790 | -0.011 | 2 | 0.778 |
VRK2 |
0.790 | 0.073 | 1 | 0.801 |
TTBK2 |
0.789 | -0.100 | 2 | 0.696 |
GRK4 |
0.789 | -0.105 | -2 | 0.783 |
RIPK1 |
0.789 | -0.095 | 1 | 0.722 |
ATM |
0.789 | -0.048 | 1 | 0.691 |
MST3 |
0.789 | 0.108 | 2 | 0.867 |
PASK |
0.789 | 0.138 | -3 | 0.873 |
DCAMKL1 |
0.789 | 0.078 | -3 | 0.797 |
FAM20C |
0.789 | -0.002 | 2 | 0.569 |
PKACA |
0.789 | 0.094 | -2 | 0.599 |
TLK2 |
0.788 | 0.003 | 1 | 0.688 |
AURA |
0.788 | 0.033 | -2 | 0.598 |
DNAPK |
0.788 | 0.011 | 1 | 0.639 |
TSSK2 |
0.788 | -0.060 | -5 | 0.737 |
CK1E |
0.788 | 0.046 | -3 | 0.607 |
TAO3 |
0.788 | 0.119 | 1 | 0.705 |
MELK |
0.788 | 0.012 | -3 | 0.805 |
NUAK1 |
0.787 | 0.011 | -3 | 0.793 |
AKT1 |
0.787 | 0.105 | -3 | 0.746 |
WNK3 |
0.787 | -0.195 | 1 | 0.716 |
SIK |
0.787 | 0.038 | -3 | 0.780 |
ALK2 |
0.787 | 0.023 | -2 | 0.774 |
SMG1 |
0.786 | -0.045 | 1 | 0.706 |
NEK2 |
0.786 | -0.023 | 2 | 0.824 |
PAK2 |
0.785 | -0.012 | -2 | 0.740 |
MYLK4 |
0.785 | 0.014 | -2 | 0.732 |
ANKRD3 |
0.785 | -0.157 | 1 | 0.747 |
BRSK1 |
0.785 | 0.022 | -3 | 0.805 |
ACVR2B |
0.785 | -0.007 | -2 | 0.758 |
PKCT |
0.785 | 0.078 | 2 | 0.734 |
PAK6 |
0.784 | 0.019 | -2 | 0.662 |
AKT3 |
0.784 | 0.132 | -3 | 0.695 |
PKCE |
0.784 | 0.116 | 2 | 0.744 |
PERK |
0.783 | -0.020 | -2 | 0.789 |
CAMK4 |
0.783 | -0.085 | -3 | 0.815 |
ACVR2A |
0.783 | -0.027 | -2 | 0.747 |
NEK5 |
0.783 | 0.045 | 1 | 0.736 |
QIK |
0.782 | -0.064 | -3 | 0.828 |
BRSK2 |
0.782 | -0.001 | -3 | 0.809 |
MEK1 |
0.781 | -0.141 | 2 | 0.822 |
BMPR1A |
0.781 | 0.051 | 1 | 0.709 |
PINK1 |
0.781 | -0.049 | 1 | 0.812 |
MARK3 |
0.780 | 0.005 | 4 | 0.706 |
SGK1 |
0.780 | 0.137 | -3 | 0.677 |
LKB1 |
0.780 | 0.101 | -3 | 0.815 |
GSK3B |
0.780 | 0.048 | 4 | 0.493 |
MEKK2 |
0.780 | 0.004 | 2 | 0.795 |
PKCI |
0.779 | 0.062 | 2 | 0.770 |
DRAK1 |
0.779 | -0.045 | 1 | 0.641 |
MEKK1 |
0.779 | -0.027 | 1 | 0.702 |
BUB1 |
0.779 | 0.169 | -5 | 0.699 |
GCK |
0.779 | 0.146 | 1 | 0.698 |
CK1D |
0.778 | 0.036 | -3 | 0.554 |
MEK5 |
0.778 | -0.092 | 2 | 0.812 |
PLK1 |
0.777 | -0.138 | -2 | 0.731 |
P70S6K |
0.777 | 0.052 | -3 | 0.747 |
CK1G1 |
0.777 | 0.009 | -3 | 0.587 |
WNK4 |
0.777 | -0.040 | -2 | 0.838 |
TNIK |
0.777 | 0.137 | 3 | 0.885 |
GRK2 |
0.777 | -0.059 | -2 | 0.684 |
IRAK4 |
0.776 | -0.008 | 1 | 0.720 |
CAMK1G |
0.776 | -0.005 | -3 | 0.789 |
BRAF |
0.776 | -0.070 | -4 | 0.687 |
ZAK |
0.776 | -0.065 | 1 | 0.666 |
CHK1 |
0.775 | -0.050 | -3 | 0.806 |
ROCK2 |
0.775 | 0.143 | -3 | 0.800 |
MEKK3 |
0.775 | -0.106 | 1 | 0.701 |
MAPKAPK5 |
0.775 | -0.050 | -3 | 0.767 |
KHS1 |
0.774 | 0.164 | 1 | 0.689 |
GAK |
0.774 | 0.075 | 1 | 0.808 |
EEF2K |
0.774 | 0.095 | 3 | 0.838 |
PLK3 |
0.773 | -0.103 | 2 | 0.752 |
KHS2 |
0.773 | 0.151 | 1 | 0.697 |
PDK1 |
0.773 | 0.034 | 1 | 0.704 |
HRI |
0.772 | -0.133 | -2 | 0.801 |
PBK |
0.772 | 0.143 | 1 | 0.751 |
TAO2 |
0.772 | 0.019 | 2 | 0.843 |
HPK1 |
0.772 | 0.080 | 1 | 0.689 |
MARK2 |
0.772 | -0.048 | 4 | 0.670 |
SMMLCK |
0.771 | -0.005 | -3 | 0.835 |
HGK |
0.771 | 0.077 | 3 | 0.877 |
CK1A2 |
0.771 | 0.007 | -3 | 0.558 |
PLK4 |
0.771 | -0.089 | 2 | 0.573 |
MAP3K15 |
0.770 | 0.087 | 1 | 0.666 |
DAPK3 |
0.770 | 0.053 | -3 | 0.820 |
MRCKB |
0.769 | 0.085 | -3 | 0.762 |
LRRK2 |
0.769 | 0.065 | 2 | 0.846 |
MINK |
0.769 | 0.058 | 1 | 0.691 |
PAK5 |
0.768 | -0.004 | -2 | 0.609 |
SSTK |
0.768 | -0.031 | 4 | 0.735 |
LOK |
0.768 | 0.057 | -2 | 0.713 |
DCAMKL2 |
0.768 | -0.021 | -3 | 0.810 |
NEK8 |
0.768 | -0.067 | 2 | 0.817 |
MEKK6 |
0.768 | 0.027 | 1 | 0.701 |
NEK11 |
0.768 | -0.068 | 1 | 0.686 |
PHKG2 |
0.768 | -0.028 | -3 | 0.794 |
SNRK |
0.767 | -0.157 | 2 | 0.640 |
CAMKK2 |
0.766 | -0.068 | -2 | 0.691 |
SLK |
0.766 | 0.045 | -2 | 0.671 |
CAMKK1 |
0.766 | -0.102 | -2 | 0.681 |
MARK1 |
0.766 | -0.073 | 4 | 0.724 |
GRK3 |
0.766 | -0.047 | -2 | 0.648 |
CAMK1D |
0.766 | 0.020 | -3 | 0.716 |
PAK4 |
0.765 | -0.002 | -2 | 0.619 |
SBK |
0.765 | 0.097 | -3 | 0.636 |
MRCKA |
0.764 | 0.065 | -3 | 0.768 |
MST2 |
0.764 | -0.029 | 1 | 0.703 |
NEK4 |
0.764 | -0.046 | 1 | 0.699 |
TLK1 |
0.763 | -0.157 | -2 | 0.786 |
DAPK1 |
0.763 | 0.030 | -3 | 0.816 |
PKN1 |
0.763 | 0.037 | -3 | 0.758 |
NEK1 |
0.762 | 0.019 | 1 | 0.710 |
DMPK1 |
0.762 | 0.107 | -3 | 0.779 |
HASPIN |
0.762 | 0.091 | -1 | 0.721 |
PDHK3_TYR |
0.760 | 0.238 | 4 | 0.863 |
CHK2 |
0.759 | 0.042 | -3 | 0.690 |
VRK1 |
0.759 | -0.015 | 2 | 0.812 |
CK2A2 |
0.758 | -0.019 | 1 | 0.628 |
YSK1 |
0.758 | 0.028 | 2 | 0.826 |
TAK1 |
0.758 | -0.070 | 1 | 0.714 |
ROCK1 |
0.758 | 0.089 | -3 | 0.772 |
CRIK |
0.758 | 0.108 | -3 | 0.749 |
OSR1 |
0.757 | 0.046 | 2 | 0.813 |
LIMK2_TYR |
0.755 | 0.210 | -3 | 0.859 |
PDHK4_TYR |
0.755 | 0.133 | 2 | 0.874 |
STK33 |
0.755 | -0.091 | 2 | 0.610 |
CAMK1A |
0.754 | 0.028 | -3 | 0.701 |
MAP2K4_TYR |
0.754 | 0.155 | -1 | 0.823 |
TESK1_TYR |
0.754 | 0.141 | 3 | 0.869 |
MYO3B |
0.754 | 0.088 | 2 | 0.829 |
PLK2 |
0.754 | -0.027 | -3 | 0.818 |
TTBK1 |
0.753 | -0.180 | 2 | 0.607 |
MST1 |
0.753 | -0.081 | 1 | 0.683 |
PKMYT1_TYR |
0.752 | 0.157 | 3 | 0.835 |
MAP2K6_TYR |
0.752 | 0.099 | -1 | 0.817 |
CK2A1 |
0.749 | -0.030 | 1 | 0.600 |
BIKE |
0.747 | 0.073 | 1 | 0.738 |
TTK |
0.747 | -0.004 | -2 | 0.773 |
PKG1 |
0.746 | 0.005 | -2 | 0.563 |
NEK3 |
0.746 | -0.073 | 1 | 0.670 |
CK1A |
0.746 | 0.003 | -3 | 0.467 |
MAP2K7_TYR |
0.746 | -0.009 | 2 | 0.836 |
PDHK1_TYR |
0.745 | 0.020 | -1 | 0.802 |
IRAK1 |
0.745 | -0.290 | -1 | 0.700 |
MEK2 |
0.745 | -0.179 | 2 | 0.781 |
YANK3 |
0.743 | -0.025 | 2 | 0.408 |
TAO1 |
0.743 | -0.005 | 1 | 0.637 |
ASK1 |
0.741 | -0.028 | 1 | 0.659 |
PINK1_TYR |
0.741 | -0.095 | 1 | 0.764 |
AAK1 |
0.741 | 0.125 | 1 | 0.670 |
BMPR2_TYR |
0.741 | -0.048 | -1 | 0.772 |
MYO3A |
0.740 | -0.004 | 1 | 0.694 |
ABL2 |
0.740 | 0.087 | -1 | 0.714 |
LIMK1_TYR |
0.739 | 0.003 | 2 | 0.827 |
RET |
0.738 | -0.010 | 1 | 0.712 |
EPHB4 |
0.738 | 0.052 | -1 | 0.718 |
TNK2 |
0.737 | 0.079 | 3 | 0.708 |
TXK |
0.737 | 0.086 | 1 | 0.719 |
FGR |
0.737 | 0.051 | 1 | 0.754 |
EPHA6 |
0.735 | 0.008 | -1 | 0.722 |
ABL1 |
0.735 | 0.055 | -1 | 0.707 |
TYRO3 |
0.733 | -0.026 | 3 | 0.783 |
LCK |
0.733 | 0.065 | -1 | 0.705 |
ROS1 |
0.733 | -0.008 | 3 | 0.746 |
YES1 |
0.733 | 0.008 | -1 | 0.761 |
RIPK2 |
0.733 | -0.276 | 1 | 0.631 |
ALPHAK3 |
0.732 | -0.049 | -1 | 0.693 |
MST1R |
0.732 | -0.055 | 3 | 0.787 |
CSF1R |
0.732 | 0.003 | 3 | 0.758 |
BLK |
0.732 | 0.076 | -1 | 0.712 |
TNNI3K_TYR |
0.731 | 0.066 | 1 | 0.715 |
TYK2 |
0.731 | -0.097 | 1 | 0.708 |
TNK1 |
0.731 | 0.060 | 3 | 0.769 |
NEK10_TYR |
0.731 | 0.001 | 1 | 0.622 |
JAK2 |
0.729 | -0.073 | 1 | 0.703 |
ITK |
0.726 | -0.014 | -1 | 0.693 |
HCK |
0.726 | -0.035 | -1 | 0.711 |
JAK1 |
0.724 | 0.013 | 1 | 0.650 |
DDR1 |
0.724 | -0.150 | 4 | 0.759 |
SRMS |
0.724 | -0.033 | 1 | 0.743 |
FER |
0.724 | -0.094 | 1 | 0.770 |
EPHA4 |
0.724 | -0.027 | 2 | 0.763 |
JAK3 |
0.723 | -0.113 | 1 | 0.691 |
WEE1_TYR |
0.723 | -0.027 | -1 | 0.691 |
BMX |
0.721 | -0.015 | -1 | 0.623 |
KDR |
0.721 | -0.070 | 3 | 0.705 |
FYN |
0.720 | 0.024 | -1 | 0.683 |
STLK3 |
0.720 | -0.155 | 1 | 0.637 |
KIT |
0.720 | -0.096 | 3 | 0.754 |
EPHB3 |
0.720 | -0.056 | -1 | 0.697 |
INSRR |
0.719 | -0.126 | 3 | 0.696 |
MET |
0.719 | -0.061 | 3 | 0.751 |
FLT3 |
0.718 | -0.133 | 3 | 0.778 |
EPHB2 |
0.718 | -0.054 | -1 | 0.682 |
MERTK |
0.717 | -0.059 | 3 | 0.731 |
EPHB1 |
0.717 | -0.094 | 1 | 0.732 |
FGFR2 |
0.717 | -0.135 | 3 | 0.732 |
PDGFRB |
0.716 | -0.151 | 3 | 0.771 |
TEC |
0.715 | -0.080 | -1 | 0.638 |
CK1G3 |
0.715 | -0.030 | -3 | 0.421 |
BTK |
0.714 | -0.131 | -1 | 0.678 |
AXL |
0.714 | -0.119 | 3 | 0.726 |
TEK |
0.713 | -0.129 | 3 | 0.693 |
PTK6 |
0.713 | -0.124 | -1 | 0.656 |
FGFR1 |
0.711 | -0.144 | 3 | 0.713 |
EPHA7 |
0.711 | -0.053 | 2 | 0.760 |
DDR2 |
0.711 | -0.008 | 3 | 0.663 |
FLT1 |
0.710 | -0.130 | -1 | 0.703 |
LYN |
0.710 | -0.074 | 3 | 0.691 |
SRC |
0.709 | -0.037 | -1 | 0.693 |
PDGFRA |
0.709 | -0.179 | 3 | 0.774 |
FRK |
0.708 | -0.085 | -1 | 0.716 |
LTK |
0.708 | -0.121 | 3 | 0.690 |
MATK |
0.708 | -0.088 | -1 | 0.656 |
EPHA1 |
0.708 | -0.094 | 3 | 0.727 |
ALK |
0.707 | -0.127 | 3 | 0.667 |
YANK2 |
0.707 | -0.060 | 2 | 0.424 |
EPHA3 |
0.706 | -0.128 | 2 | 0.728 |
FGFR3 |
0.706 | -0.148 | 3 | 0.700 |
PTK2B |
0.705 | -0.063 | -1 | 0.673 |
NTRK1 |
0.705 | -0.184 | -1 | 0.727 |
ERBB2 |
0.704 | -0.179 | 1 | 0.656 |
EPHA5 |
0.703 | -0.074 | 2 | 0.739 |
NTRK3 |
0.703 | -0.121 | -1 | 0.692 |
SYK |
0.702 | -0.026 | -1 | 0.637 |
CSK |
0.702 | -0.104 | 2 | 0.756 |
INSR |
0.701 | -0.164 | 3 | 0.693 |
EPHA8 |
0.701 | -0.093 | -1 | 0.671 |
FLT4 |
0.698 | -0.216 | 3 | 0.699 |
EGFR |
0.698 | -0.107 | 1 | 0.564 |
NTRK2 |
0.698 | -0.224 | 3 | 0.703 |
PTK2 |
0.698 | -0.056 | -1 | 0.628 |
CK1G2 |
0.697 | -0.036 | -3 | 0.509 |
FGFR4 |
0.697 | -0.110 | -1 | 0.666 |
ZAP70 |
0.693 | 0.001 | -1 | 0.585 |
MUSK |
0.689 | -0.135 | 1 | 0.567 |
EPHA2 |
0.688 | -0.110 | -1 | 0.629 |
ERBB4 |
0.686 | -0.094 | 1 | 0.581 |
IGF1R |
0.683 | -0.181 | 3 | 0.626 |
FES |
0.670 | -0.167 | -1 | 0.602 |