Motif 155 (n=151)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| K7ELQ4 | ATF7-NPFF | S100 | ochoa | ATF7-NPFF readthrough | None |
| O00512 | BCL9 | S907 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14497 | ARID1A | S301 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O15055 | PER2 | S977 | ochoa | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15504 | NUP42 | S309 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O43166 | SIPA1L1 | S1695 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43237 | DYNC1LI2 | S381 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43294 | TGFB1I1 | S164 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O60292 | SIPA1L3 | S1440 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75128 | COBL | S574 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75150 | RNF40 | S523 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75563 | SKAP2 | S90 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O95425 | SVIL | S1225 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95453 | PARN | S163 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95613 | PCNT | S3274 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95785 | WIZ | S1517 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95977 | S1PR4 | S349 | ochoa | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}. |
| P02730 | SLC4A1 | S745 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P06132 | UROD | S61 | ochoa | Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) | Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824). {ECO:0000269|PubMed:11069625, ECO:0000269|PubMed:11719352, ECO:0000269|PubMed:12071824, ECO:0000269|PubMed:14633982, ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:21668429}. |
| P0CG12 | DERPC | S291 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
| P12270 | TPR | S640 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12270 | TPR | S1660 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12270 | TPR | S1662 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12755 | SKI | S432 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P15336 | ATF2 | S340 | ochoa|psp | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P18206 | VCL | S600 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P25054 | APC | S1664 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26358 | DNMT1 | S127 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27448 | MARK3 | S476 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P28062 | PSMB8 | S28 | ochoa | Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein) | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:8163024}. |
| P29353 | SHC1 | S453 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P33527 | ABCC1 | S871 | psp | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P42695 | NCAPD3 | S1321 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46013 | MKI67 | S827 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46379 | BAG6 | S973 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P46379 | BAG6 | S1081 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P47974 | ZFP36L2 | S59 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48634 | PRRC2A | S2113 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49796 | RGS3 | S401 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P52948 | NUP98 | S494 | psp | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P78413 | IRX4 | S473 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
| P98172 | EFNB1 | S287 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| Q00056 | HOXA4 | S109 | ochoa | Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. |
| Q00872 | MYBPC1 | S825 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01362 | MS4A2 | S19 | ochoa | High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2) | High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. |
| Q01484 | ANK2 | S2440 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q12955 | ANK3 | S623 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q12988 | HSPB3 | S53 | ochoa | Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) | Inhibitor of actin polymerization. |
| Q13133 | NR1H3 | S197 | ochoa | Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (PubMed:37478846). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:37478846}. |
| Q13428 | TCOF1 | S1069 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14004 | CDK13 | S864 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q15436 | SEC23A | S207 | psp | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q01405, ECO:0000269|PubMed:16980979, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:27551091, ECO:0000269|PubMed:8898360}. |
| Q15528 | MED22 | S173 | ochoa | Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q15714 | TSC22D1 | S1047 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q15772 | SPEG | S2164 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16825 | PTPN21 | S492 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2TV78 | MST1L | S398 | ochoa | Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog) | None |
| Q49AM3 | TTC31 | S278 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q5BJH7 | YIF1B | S65 | ochoa | Protein YIF1B (YIP1-interacting factor homolog B) | Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (PubMed:33103737). {ECO:0000250|UniProtKB:Q6PEC3, ECO:0000250|UniProtKB:Q9CX30, ECO:0000269|PubMed:33103737}. |
| Q5JR12 | PPM1J | S68 | ochoa | Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) | None |
| Q5T1R4 | HIVEP3 | S739 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5P2 | KIAA1217 | S1711 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5Y3 | CAMSAP1 | S470 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TCZ1 | SH3PXD2A | S1043 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TGY3 | AHDC1 | S1011 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TGY3 | AHDC1 | S1507 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VT97 | SYDE2 | S223 | ochoa | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q5VTQ0 | TTC39B | S526 | ochoa | Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) | Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}. |
| Q63ZY3 | KANK2 | S19 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q66K64 | DCAF15 | S373 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q6N021 | TET2 | S1518 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
| Q6N043 | ZNF280D | S530 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6NV74 | CRACDL | S520 | ochoa | CRACD-like protein | None |
| Q6P1N0 | CC2D1A | S292 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6ZRI6 | C15orf39 | S391 | ochoa | Uncharacterized protein C15orf39 | None |
| Q76L83 | ASXL2 | S1284 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L3V2 | RTL10 | S34 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
| Q7Z4H7 | HAUS6 | S530 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z5L9 | IRF2BP2 | S212 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86V15 | CASZ1 | S750 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86X51 | EZHIP | S222 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86XK2 | FBXO11 | S97 | ochoa | F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:33156908, ECO:0000269|PubMed:36897010, ECO:0000269|PubMed:37279268}. |
| Q86XZ4 | SPATS2 | S408 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IY92 | SLX4 | S1028 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYK8 | REM2 | S27 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
| Q8N350 | CBARP | S378 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N884 | CGAS | S64 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NC56 | LEMD2 | S82 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NDX1 | PSD4 | S763 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEG4 | FAM83F | Y107 | ochoa | Protein FAM83F | None |
| Q8NEY1 | NAV1 | S142 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFH5 | NUP35 | S55 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8TAD8 | SNIP1 | S35 | ochoa|psp | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TBP0 | TBC1D16 | S155 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TC90 | CCER1 | S226 | ochoa | Coiled-coil domain-containing glutamate-rich protein 1 | Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation. {ECO:0000250|UniProtKB:Q9CQL2}. |
| Q8TEK3 | DOT1L | S448 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q92576 | PHF3 | S1168 | ochoa | PHD finger protein 3 | None |
| Q92619 | ARHGAP45 | S93 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92997 | DVL3 | S516 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96AC6 | KIFC2 | S612 | ochoa | Kinesin-like protein KIFC2 | May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity). {ECO:0000250}. |
| Q96C12 | ARMC5 | S82 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96DF8 | ESS2 | S433 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96FI4 | NEIL1 | S61 | psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
| Q96PE2 | ARHGEF17 | S383 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PE2 | ARHGEF17 | S829 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PK6 | RBM14 | S523 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96RS0 | TGS1 | S405 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99459 | CDC5L | S334 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99536 | VAT1 | S27 | ochoa | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| Q99536 | VAT1 | S35 | ochoa | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| Q99988 | GDF15 | S39 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BQ15 | NABP2 | S134 | psp | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}. |
| Q9BTX1 | NDC1 | S396 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BXF6 | RAB11FIP5 | S418 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BYB0 | SHANK3 | S1121 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BYJ9 | YTHDF1 | S252 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9BZ71 | PITPNM3 | S495 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9C0K1 | SLC39A8 | S275 | ochoa | Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) | Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:26637978, PubMed:29337306, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). {ECO:0000250|UniProtKB:Q91W10, ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:22898811, ECO:0000269|PubMed:23403290, ECO:0000269|PubMed:26637978, ECO:0000269|PubMed:27166256, ECO:0000269|PubMed:27466201, ECO:0000269|PubMed:28056086, ECO:0000269|PubMed:28481222, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:29453449, ECO:0000269|PubMed:29927450, ECO:0000269|PubMed:31699897}. |
| Q9H0Z9 | RBM38 | S195 | psp | RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) | RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}.; FUNCTION: (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication. {ECO:0000269|PubMed:29437973}. |
| Q9H792 | PEAK1 | S773 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H981 | ACTR8 | S446 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9H987 | SYNPO2L | S421 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9NPF5 | DMAP1 | S418 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NQ84 | GPRC5C | S406 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NX00 | TMEM160 | S48 | ochoa | Transmembrane protein 160 | None |
| Q9NYV4 | CDK12 | S886 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZC9 | SMARCAL1 | S198 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P2D0 | IBTK | S1045 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UJF2 | RASAL2 | S754 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UJY5 | GGA1 | S317 | ochoa | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9ULR3 | PPM1H | S211 | ochoa | Protein phosphatase 1H (EC 3.1.3.16) | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}. |
| Q9UMS6 | SYNPO2 | S910 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UQ35 | SRRM2 | S1179 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQF2 | MAPK8IP1 | S29 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y250 | LZTS1 | S146 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y253 | POLH | S497 | ochoa | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
| Q9Y490 | TLN1 | S458 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S677 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S461 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y6K9 | IKBKG | S31 | ochoa|psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| O60664 | PLIN3 | S225 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O15146 | MUSK | S752 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| P26641 | EEF1G | S25 | Sugiyama | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| Q8WZA9 | IRGQ | S538 | Sugiyama | Immunity-related GTPase family Q protein | Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378). {ECO:0000269|PubMed:39481378}. |
| P43403 | ZAP70 | S263 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P51451 | BLK | S387 | Sugiyama | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}. |
| O60610 | DIAPH1 | S1235 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| Q9UPQ9 | TNRC6B | S992 | Sugiyama | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| P78347 | GTF2I | S764 | EPSD | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P20933 | AGA | S49 | Sugiyama | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. {ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874, ECO:0000269|PubMed:2401370}. |
| Q14524 | SCN5A | S61 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.642396e-07 | 6.785 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.971824e-07 | 6.705 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.971824e-07 | 6.705 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.799635e-07 | 6.553 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.799635e-07 | 6.553 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.312578e-07 | 6.480 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.578113e-07 | 6.339 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 8.349136e-07 | 6.078 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.227404e-07 | 6.206 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.248876e-07 | 6.084 |
| R-HSA-191859 | snRNP Assembly | 8.248876e-07 | 6.084 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.312578e-07 | 6.480 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.591444e-07 | 6.181 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.902390e-07 | 6.409 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 7.223121e-07 | 6.141 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.262799e-07 | 6.083 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.262799e-07 | 6.083 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.349136e-07 | 6.078 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 9.618813e-07 | 6.017 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 9.618813e-07 | 6.017 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 9.618813e-07 | 6.017 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.104652e-06 | 5.957 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.113366e-06 | 5.675 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.387275e-06 | 5.622 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.160586e-05 | 4.935 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.272123e-05 | 4.895 |
| R-HSA-68875 | Mitotic Prophase | 1.740472e-05 | 4.759 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.962016e-05 | 4.528 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.202332e-05 | 4.495 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.731186e-05 | 4.428 |
| R-HSA-211000 | Gene Silencing by RNA | 5.102454e-05 | 4.292 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.177502e-05 | 4.209 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.776987e-05 | 4.169 |
| R-HSA-70171 | Glycolysis | 2.223073e-04 | 3.653 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.474560e-04 | 3.607 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.818561e-04 | 3.418 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.298760e-04 | 3.367 |
| R-HSA-70326 | Glucose metabolism | 5.932517e-04 | 3.227 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.028807e-04 | 3.220 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 7.332525e-04 | 3.135 |
| R-HSA-9842663 | Signaling by LTK | 7.332525e-04 | 3.135 |
| R-HSA-3371556 | Cellular response to heat stress | 7.066903e-04 | 3.151 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.376446e-04 | 3.132 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.025391e-04 | 3.096 |
| R-HSA-5619102 | SLC transporter disorders | 9.608710e-04 | 3.017 |
| R-HSA-68886 | M Phase | 1.496943e-03 | 2.825 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.575990e-03 | 2.802 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.600352e-03 | 2.796 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.859397e-03 | 2.731 |
| R-HSA-9609690 | HCMV Early Events | 2.443605e-03 | 2.612 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 2.675892e-03 | 2.573 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 2.675892e-03 | 2.573 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.863373e-03 | 2.543 |
| R-HSA-9610379 | HCMV Late Events | 3.048885e-03 | 2.516 |
| R-HSA-162587 | HIV Life Cycle | 3.048885e-03 | 2.516 |
| R-HSA-72306 | tRNA processing | 4.617487e-03 | 2.336 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 5.175758e-03 | 2.286 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.632259e-03 | 2.249 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.877538e-03 | 2.231 |
| R-HSA-168255 | Influenza Infection | 5.906986e-03 | 2.229 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.515091e-03 | 2.186 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 7.143467e-03 | 2.146 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 7.592515e-03 | 2.120 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.692679e-03 | 2.061 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.019056e-02 | 1.992 |
| R-HSA-9609646 | HCMV Infection | 9.255290e-03 | 2.034 |
| R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 1.068617e-02 | 1.971 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.068617e-02 | 1.971 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.161683e-02 | 1.935 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.225745e-02 | 1.912 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.225745e-02 | 1.912 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.383954e-02 | 1.859 |
| R-HSA-201556 | Signaling by ALK | 1.379093e-02 | 1.860 |
| R-HSA-913531 | Interferon Signaling | 1.254284e-02 | 1.902 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.551495e-02 | 1.809 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.628692e-02 | 1.788 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.628692e-02 | 1.788 |
| R-HSA-162906 | HIV Infection | 1.806402e-02 | 1.743 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.812558e-02 | 1.742 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.812558e-02 | 1.742 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.097425e-02 | 1.678 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.097425e-02 | 1.678 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.097425e-02 | 1.678 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.097425e-02 | 1.678 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.990516e-02 | 1.701 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.899516e-02 | 1.721 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.125879e-02 | 1.672 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.183630e-02 | 1.661 |
| R-HSA-9634597 | GPER1 signaling | 2.303477e-02 | 1.638 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.379949e-02 | 1.623 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.422125e-02 | 1.616 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.546338e-02 | 1.594 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.583227e-02 | 1.588 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.583227e-02 | 1.588 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.612697e-02 | 1.583 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.793293e-02 | 1.554 |
| R-HSA-2262752 | Cellular responses to stress | 3.132530e-02 | 1.504 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.741730e-02 | 1.562 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.171907e-02 | 1.499 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 3.171907e-02 | 1.499 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.171907e-02 | 1.499 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 3.171907e-02 | 1.499 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 3.233131e-02 | 1.490 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 3.462577e-02 | 1.461 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.462577e-02 | 1.461 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 4.206820e-02 | 1.376 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.230735e-02 | 1.281 |
| R-HSA-8941237 | Invadopodia formation | 5.230735e-02 | 1.281 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 6.243768e-02 | 1.205 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.018936e-01 | 0.992 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 1.018936e-01 | 0.992 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 1.018936e-01 | 0.992 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 1.018936e-01 | 0.992 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.114969e-01 | 0.953 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.114969e-01 | 0.953 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.209980e-01 | 0.917 |
| R-HSA-9613354 | Lipophagy | 1.209980e-01 | 0.917 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.209980e-01 | 0.917 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.303982e-01 | 0.885 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.396983e-01 | 0.855 |
| R-HSA-4839744 | Signaling by APC mutants | 1.396983e-01 | 0.855 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.396983e-01 | 0.855 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.396983e-01 | 0.855 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.396983e-01 | 0.855 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 4.187129e-02 | 1.378 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.488996e-01 | 0.827 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.488996e-01 | 0.827 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.488996e-01 | 0.827 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.488996e-01 | 0.827 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.580031e-01 | 0.801 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.580031e-01 | 0.801 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.580031e-01 | 0.801 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.580031e-01 | 0.801 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.580031e-01 | 0.801 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.580031e-01 | 0.801 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 4.962816e-02 | 1.304 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.670097e-01 | 0.777 |
| R-HSA-9615710 | Late endosomal microautophagy | 5.506397e-02 | 1.259 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.847366e-01 | 0.733 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.847366e-01 | 0.733 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.847366e-01 | 0.733 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.847366e-01 | 0.733 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.934588e-01 | 0.713 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 2.020883e-01 | 0.694 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.106260e-01 | 0.676 |
| R-HSA-3928664 | Ephrin signaling | 2.190729e-01 | 0.659 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.274299e-01 | 0.643 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.356979e-01 | 0.628 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.356979e-01 | 0.628 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.777072e-01 | 0.750 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.777072e-01 | 0.750 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.892438e-01 | 0.723 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.165170e-01 | 0.665 |
| R-HSA-380287 | Centrosome maturation | 2.243776e-01 | 0.649 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.362078e-01 | 0.627 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.488996e-01 | 0.827 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.020883e-01 | 0.694 |
| R-HSA-9646399 | Aggrephagy | 9.148384e-02 | 1.039 |
| R-HSA-354192 | Integrin signaling | 6.652054e-02 | 1.177 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.479859e-02 | 1.349 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.847366e-01 | 0.733 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.117013e-01 | 0.952 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.962816e-02 | 1.304 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 7.246034e-02 | 1.140 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.759205e-01 | 0.755 |
| R-HSA-9664420 | Killing mechanisms | 1.934588e-01 | 0.713 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.934588e-01 | 0.713 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 1.303982e-01 | 0.885 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.759205e-01 | 0.755 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.847366e-01 | 0.733 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.960757e-02 | 1.099 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.447461e-01 | 0.839 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.033544e-01 | 0.986 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.324845e-01 | 0.878 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.237647e-02 | 1.084 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.488996e-01 | 0.827 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.488996e-01 | 0.827 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.580031e-01 | 0.801 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.847366e-01 | 0.733 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.020883e-01 | 0.694 |
| R-HSA-167044 | Signalling to RAS | 2.438780e-01 | 0.613 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.091627e-01 | 0.962 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.447461e-01 | 0.839 |
| R-HSA-68882 | Mitotic Anaphase | 1.121246e-01 | 0.950 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.135901e-01 | 0.945 |
| R-HSA-74749 | Signal attenuation | 1.303982e-01 | 0.885 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.356979e-01 | 0.628 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.636493e-02 | 1.178 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.209980e-01 | 0.917 |
| R-HSA-8851805 | MET activates RAS signaling | 1.580031e-01 | 0.801 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.670097e-01 | 0.777 |
| R-HSA-8853659 | RET signaling | 7.868690e-02 | 1.104 |
| R-HSA-5260271 | Diseases of Immune System | 9.148384e-02 | 1.039 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 9.148384e-02 | 1.039 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.601691e-02 | 1.252 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.580031e-01 | 0.801 |
| R-HSA-1483226 | Synthesis of PI | 1.396983e-01 | 0.855 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.396983e-01 | 0.855 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.438780e-01 | 0.613 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.150136e-01 | 0.668 |
| R-HSA-9663891 | Selective autophagy | 8.765103e-02 | 1.057 |
| R-HSA-68877 | Mitotic Prometaphase | 1.951390e-01 | 0.710 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.365697e-01 | 0.865 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.331148e-02 | 1.363 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.477283e-02 | 1.023 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.737864e-01 | 0.760 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.934588e-01 | 0.713 |
| R-HSA-5689603 | UCH proteinases | 2.283164e-01 | 0.641 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.190729e-01 | 0.659 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 8.237647e-02 | 1.084 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.479859e-02 | 1.349 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.053729e-02 | 1.296 |
| R-HSA-425381 | Bicarbonate transporters | 1.396983e-01 | 0.855 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.580031e-01 | 0.801 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.580031e-01 | 0.801 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.580031e-01 | 0.801 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.759205e-01 | 0.755 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.402169e-01 | 0.853 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.397967e-01 | 0.855 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.564999e-02 | 1.255 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.587511e-01 | 0.799 |
| R-HSA-9909396 | Circadian clock | 7.655196e-02 | 1.116 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.106260e-01 | 0.676 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.106260e-01 | 0.676 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.396983e-01 | 0.855 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.759205e-01 | 0.755 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.759205e-01 | 0.755 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 1.847366e-01 | 0.733 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.934588e-01 | 0.713 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 8.822962e-02 | 1.054 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.438780e-01 | 0.613 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.422641e-01 | 0.847 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.522769e-01 | 0.817 |
| R-HSA-450294 | MAP kinase activation | 1.700803e-01 | 0.769 |
| R-HSA-1632852 | Macroautophagy | 2.417061e-01 | 0.617 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.599299e-01 | 0.796 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.847366e-01 | 0.733 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.106260e-01 | 0.676 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 5.506397e-02 | 1.259 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 5.785703e-02 | 1.238 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 7.558319e-02 | 1.122 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.438780e-01 | 0.613 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.438780e-01 | 0.613 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.580100e-02 | 1.339 |
| R-HSA-448424 | Interleukin-17 signaling | 2.047768e-01 | 0.689 |
| R-HSA-397014 | Muscle contraction | 2.400189e-01 | 0.620 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 8.237647e-02 | 1.084 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.209980e-01 | 0.917 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.580031e-01 | 0.801 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 7.558319e-02 | 1.122 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.106260e-01 | 0.676 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.190729e-01 | 0.659 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.018936e-01 | 0.992 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.303982e-01 | 0.885 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 8.182999e-02 | 1.087 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.274299e-01 | 0.643 |
| R-HSA-8854214 | TBC/RABGAPs | 1.048375e-01 | 0.979 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 7.558319e-02 | 1.122 |
| R-HSA-8953854 | Metabolism of RNA | 2.113832e-01 | 0.675 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.934588e-01 | 0.713 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.274299e-01 | 0.643 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.931122e-01 | 0.714 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.016993e-01 | 0.695 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.396983e-01 | 0.855 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.698819e-02 | 1.328 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.934588e-01 | 0.713 |
| R-HSA-5693538 | Homology Directed Repair | 1.703121e-01 | 0.769 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.533175e-01 | 0.814 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.533175e-01 | 0.814 |
| R-HSA-1640170 | Cell Cycle | 9.520361e-02 | 1.021 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.396983e-01 | 0.855 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.962816e-02 | 1.304 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.274299e-01 | 0.643 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.048375e-01 | 0.979 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.401594e-01 | 0.620 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.117013e-01 | 0.952 |
| R-HSA-166520 | Signaling by NTRKs | 1.050503e-01 | 0.979 |
| R-HSA-8939211 | ESR-mediated signaling | 1.447730e-01 | 0.839 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.441143e-01 | 0.612 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.512813e-01 | 0.820 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.260889e-02 | 1.279 |
| R-HSA-9707616 | Heme signaling | 1.738868e-01 | 0.760 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.084801e-01 | 0.965 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.276873e-01 | 0.894 |
| R-HSA-435354 | Zinc transporters | 1.759205e-01 | 0.755 |
| R-HSA-373760 | L1CAM interactions | 1.650964e-01 | 0.782 |
| R-HSA-210993 | Tie2 Signaling | 2.190729e-01 | 0.659 |
| R-HSA-189445 | Metabolism of porphyrins | 2.086826e-01 | 0.681 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.300780e-01 | 0.886 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.300780e-01 | 0.886 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.077842e-01 | 0.967 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.548147e-01 | 0.810 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.441143e-01 | 0.612 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.206129e-01 | 0.919 |
| R-HSA-9679506 | SARS-CoV Infections | 1.691398e-01 | 0.772 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.424194e-01 | 0.846 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.480719e-01 | 0.605 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.519711e-01 | 0.599 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.519711e-01 | 0.599 |
| R-HSA-418990 | Adherens junctions interactions | 2.539365e-01 | 0.595 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.559931e-01 | 0.592 |
| R-HSA-195721 | Signaling by WNT | 2.577698e-01 | 0.589 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.599559e-01 | 0.585 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.639193e-01 | 0.579 |
| R-HSA-597592 | Post-translational protein modification | 2.642742e-01 | 0.578 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.646330e-01 | 0.577 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.678831e-01 | 0.572 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.678831e-01 | 0.572 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.678997e-01 | 0.572 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.678997e-01 | 0.572 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.727443e-01 | 0.564 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.757371e-01 | 0.560 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.757371e-01 | 0.560 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.757371e-01 | 0.560 |
| R-HSA-429947 | Deadenylation of mRNA | 2.757371e-01 | 0.560 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.790987e-01 | 0.554 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.797716e-01 | 0.553 |
| R-HSA-9839394 | TGFBR3 expression | 2.834910e-01 | 0.547 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.834910e-01 | 0.547 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.834910e-01 | 0.547 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.837320e-01 | 0.547 |
| R-HSA-1989781 | PPARA activates gene expression | 2.849072e-01 | 0.545 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.876905e-01 | 0.541 |
| R-HSA-9612973 | Autophagy | 2.878154e-01 | 0.541 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.907260e-01 | 0.537 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.911625e-01 | 0.536 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.911625e-01 | 0.536 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.911625e-01 | 0.536 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.917852e-01 | 0.535 |
| R-HSA-1500931 | Cell-Cell communication | 2.946297e-01 | 0.531 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.987522e-01 | 0.525 |
| R-HSA-201451 | Signaling by BMP | 2.987522e-01 | 0.525 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.062612e-01 | 0.514 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.062612e-01 | 0.514 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.136902e-01 | 0.503 |
| R-HSA-5334118 | DNA methylation | 3.136902e-01 | 0.503 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.136902e-01 | 0.503 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.136902e-01 | 0.503 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.136902e-01 | 0.503 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.136902e-01 | 0.503 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.136902e-01 | 0.503 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.192431e-01 | 0.496 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.192431e-01 | 0.496 |
| R-HSA-2424491 | DAP12 signaling | 3.210401e-01 | 0.493 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.210401e-01 | 0.493 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.210401e-01 | 0.493 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.270856e-01 | 0.485 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.270856e-01 | 0.485 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.270856e-01 | 0.485 |
| R-HSA-190236 | Signaling by FGFR | 3.270856e-01 | 0.485 |
| R-HSA-4839726 | Chromatin organization | 3.279175e-01 | 0.484 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.283117e-01 | 0.484 |
| R-HSA-3214847 | HATs acetylate histones | 3.309981e-01 | 0.480 |
| R-HSA-421270 | Cell-cell junction organization | 3.327625e-01 | 0.478 |
| R-HSA-418555 | G alpha (s) signalling events | 3.345463e-01 | 0.476 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.349043e-01 | 0.475 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.355060e-01 | 0.474 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.355060e-01 | 0.474 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.355060e-01 | 0.474 |
| R-HSA-5688426 | Deubiquitination | 3.424632e-01 | 0.465 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.426236e-01 | 0.465 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.426236e-01 | 0.465 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.426236e-01 | 0.465 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.426236e-01 | 0.465 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.426236e-01 | 0.465 |
| R-HSA-390522 | Striated Muscle Contraction | 3.496654e-01 | 0.456 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.496654e-01 | 0.456 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.496654e-01 | 0.456 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.496654e-01 | 0.456 |
| R-HSA-189483 | Heme degradation | 3.496654e-01 | 0.456 |
| R-HSA-5673000 | RAF activation | 3.566322e-01 | 0.448 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.566322e-01 | 0.448 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.566322e-01 | 0.448 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.566322e-01 | 0.448 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.566322e-01 | 0.448 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.566322e-01 | 0.448 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.566322e-01 | 0.448 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.635247e-01 | 0.439 |
| R-HSA-187687 | Signalling to ERKs | 3.635247e-01 | 0.439 |
| R-HSA-381042 | PERK regulates gene expression | 3.635247e-01 | 0.439 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.697296e-01 | 0.432 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.703439e-01 | 0.431 |
| R-HSA-163560 | Triglyceride catabolism | 3.703439e-01 | 0.431 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.703439e-01 | 0.431 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.735572e-01 | 0.428 |
| R-HSA-4641258 | Degradation of DVL | 3.770904e-01 | 0.424 |
| R-HSA-202403 | TCR signaling | 3.773755e-01 | 0.423 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.837651e-01 | 0.416 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.837651e-01 | 0.416 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 3.849833e-01 | 0.415 |
| R-HSA-73894 | DNA Repair | 3.874545e-01 | 0.412 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.903686e-01 | 0.409 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.903686e-01 | 0.409 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.925511e-01 | 0.406 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.927341e-01 | 0.406 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.969018e-01 | 0.401 |
| R-HSA-202433 | Generation of second messenger molecules | 3.969018e-01 | 0.401 |
| R-HSA-446728 | Cell junction organization | 3.982324e-01 | 0.400 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.013725e-01 | 0.396 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.033654e-01 | 0.394 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.033654e-01 | 0.394 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.033654e-01 | 0.394 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.033654e-01 | 0.394 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.038240e-01 | 0.394 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.038240e-01 | 0.394 |
| R-HSA-422475 | Axon guidance | 4.068791e-01 | 0.391 |
| R-HSA-6798695 | Neutrophil degranulation | 4.081155e-01 | 0.389 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.097601e-01 | 0.387 |
| R-HSA-189451 | Heme biosynthesis | 4.097601e-01 | 0.387 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.097601e-01 | 0.387 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.112843e-01 | 0.386 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.112843e-01 | 0.386 |
| R-HSA-73928 | Depyrimidination | 4.160866e-01 | 0.381 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.160866e-01 | 0.381 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.160866e-01 | 0.381 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.185444e-01 | 0.378 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.186990e-01 | 0.378 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.186990e-01 | 0.378 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.186990e-01 | 0.378 |
| R-HSA-9710421 | Defective pyroptosis | 4.223458e-01 | 0.374 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.223458e-01 | 0.374 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.260665e-01 | 0.371 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.260665e-01 | 0.371 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.270716e-01 | 0.369 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.285382e-01 | 0.368 |
| R-HSA-2172127 | DAP12 interactions | 4.285382e-01 | 0.368 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.285382e-01 | 0.368 |
| R-HSA-9907900 | Proteasome assembly | 4.285382e-01 | 0.368 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 4.285382e-01 | 0.368 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.285382e-01 | 0.368 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.297321e-01 | 0.367 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.297321e-01 | 0.367 |
| R-HSA-199991 | Membrane Trafficking | 4.297457e-01 | 0.367 |
| R-HSA-72172 | mRNA Splicing | 4.327325e-01 | 0.364 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.333855e-01 | 0.363 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.333855e-01 | 0.363 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.346646e-01 | 0.362 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.346646e-01 | 0.362 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.381703e-01 | 0.358 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.407257e-01 | 0.356 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.407257e-01 | 0.356 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.407257e-01 | 0.356 |
| R-HSA-9675135 | Diseases of DNA repair | 4.407257e-01 | 0.356 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.407257e-01 | 0.356 |
| R-HSA-75153 | Apoptotic execution phase | 4.407257e-01 | 0.356 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.467222e-01 | 0.350 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.467222e-01 | 0.350 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.467222e-01 | 0.350 |
| R-HSA-114608 | Platelet degranulation | 4.514628e-01 | 0.345 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.526548e-01 | 0.344 |
| R-HSA-425410 | Metal ion SLC transporters | 4.526548e-01 | 0.344 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.550394e-01 | 0.342 |
| R-HSA-73893 | DNA Damage Bypass | 4.585241e-01 | 0.339 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.643309e-01 | 0.333 |
| R-HSA-1474165 | Reproduction | 4.656888e-01 | 0.332 |
| R-HSA-9843745 | Adipogenesis | 4.692115e-01 | 0.329 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.700757e-01 | 0.328 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.700757e-01 | 0.328 |
| R-HSA-9675108 | Nervous system development | 4.714806e-01 | 0.327 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.727204e-01 | 0.325 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.757593e-01 | 0.323 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.757593e-01 | 0.323 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.762154e-01 | 0.322 |
| R-HSA-74160 | Gene expression (Transcription) | 4.772725e-01 | 0.321 |
| R-HSA-72649 | Translation initiation complex formation | 4.869452e-01 | 0.313 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.869452e-01 | 0.313 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.900548e-01 | 0.310 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.900548e-01 | 0.310 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.924489e-01 | 0.308 |
| R-HSA-9753281 | Paracetamol ADME | 4.924489e-01 | 0.308 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.974046e-01 | 0.303 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.978938e-01 | 0.303 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.978938e-01 | 0.303 |
| R-HSA-177929 | Signaling by EGFR | 4.978938e-01 | 0.303 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.978938e-01 | 0.303 |
| R-HSA-75893 | TNF signaling | 4.978938e-01 | 0.303 |
| R-HSA-6807070 | PTEN Regulation | 5.002840e-01 | 0.301 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.032807e-01 | 0.298 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.086102e-01 | 0.294 |
| R-HSA-162582 | Signal Transduction | 5.118022e-01 | 0.291 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.138827e-01 | 0.289 |
| R-HSA-8979227 | Triglyceride metabolism | 5.138827e-01 | 0.289 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.142969e-01 | 0.289 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.190990e-01 | 0.285 |
| R-HSA-983189 | Kinesins | 5.190990e-01 | 0.285 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.190990e-01 | 0.285 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.190990e-01 | 0.285 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.203458e-01 | 0.284 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.242597e-01 | 0.280 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.242996e-01 | 0.280 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.344164e-01 | 0.272 |
| R-HSA-373755 | Semaphorin interactions | 5.344164e-01 | 0.272 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.394136e-01 | 0.268 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.394136e-01 | 0.268 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.430672e-01 | 0.265 |
| R-HSA-73887 | Death Receptor Signaling | 5.525753e-01 | 0.258 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.588749e-01 | 0.253 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.588749e-01 | 0.253 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.650360e-01 | 0.248 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.682966e-01 | 0.245 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.682966e-01 | 0.245 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.682966e-01 | 0.245 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.682966e-01 | 0.245 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.711729e-01 | 0.243 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.729322e-01 | 0.242 |
| R-HSA-3000178 | ECM proteoglycans | 5.729322e-01 | 0.242 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.729322e-01 | 0.242 |
| R-HSA-109581 | Apoptosis | 5.772473e-01 | 0.239 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.775183e-01 | 0.238 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.775183e-01 | 0.238 |
| R-HSA-4086398 | Ca2+ pathway | 5.820555e-01 | 0.235 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.820555e-01 | 0.235 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.832590e-01 | 0.234 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.865441e-01 | 0.232 |
| R-HSA-8852135 | Protein ubiquitination | 5.909849e-01 | 0.228 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.996969e-01 | 0.222 |
| R-HSA-4086400 | PCP/CE pathway | 6.040246e-01 | 0.219 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.040246e-01 | 0.219 |
| R-HSA-168256 | Immune System | 6.111113e-01 | 0.214 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.124873e-01 | 0.213 |
| R-HSA-6806834 | Signaling by MET | 6.124873e-01 | 0.213 |
| R-HSA-9833482 | PKR-mediated signaling | 6.124873e-01 | 0.213 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.136398e-01 | 0.212 |
| R-HSA-977225 | Amyloid fiber formation | 6.166509e-01 | 0.210 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.288769e-01 | 0.201 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.328655e-01 | 0.199 |
| R-HSA-1266738 | Developmental Biology | 6.390052e-01 | 0.194 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.407151e-01 | 0.193 |
| R-HSA-69275 | G2/M Transition | 6.478855e-01 | 0.189 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.483980e-01 | 0.188 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.531154e-01 | 0.185 |
| R-HSA-73884 | Base Excision Repair | 6.559174e-01 | 0.183 |
| R-HSA-202424 | Downstream TCR signaling | 6.559174e-01 | 0.183 |
| R-HSA-5617833 | Cilium Assembly | 6.582836e-01 | 0.182 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.596169e-01 | 0.181 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.596169e-01 | 0.181 |
| R-HSA-1643685 | Disease | 6.600152e-01 | 0.180 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.668978e-01 | 0.176 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.668978e-01 | 0.176 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.668978e-01 | 0.176 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.668978e-01 | 0.176 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.704800e-01 | 0.174 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.710482e-01 | 0.173 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.775298e-01 | 0.169 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.809982e-01 | 0.167 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.844296e-01 | 0.165 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.844296e-01 | 0.165 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.878243e-01 | 0.163 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.945051e-01 | 0.158 |
| R-HSA-9824446 | Viral Infection Pathways | 6.952887e-01 | 0.158 |
| R-HSA-5357801 | Programmed Cell Death | 6.974436e-01 | 0.156 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.977920e-01 | 0.156 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.010437e-01 | 0.154 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.033278e-01 | 0.153 |
| R-HSA-392499 | Metabolism of proteins | 7.040260e-01 | 0.152 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.042607e-01 | 0.152 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.042607e-01 | 0.152 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.105917e-01 | 0.148 |
| R-HSA-9833110 | RSV-host interactions | 7.137065e-01 | 0.146 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.151024e-01 | 0.146 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.167880e-01 | 0.145 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.258359e-01 | 0.139 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.258359e-01 | 0.139 |
| R-HSA-8951664 | Neddylation | 7.328381e-01 | 0.135 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.402815e-01 | 0.131 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.485829e-01 | 0.126 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.539701e-01 | 0.123 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.539701e-01 | 0.123 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.690228e-01 | 0.114 |
| R-HSA-168249 | Innate Immune System | 7.916459e-01 | 0.101 |
| R-HSA-5576891 | Cardiac conduction | 7.953642e-01 | 0.099 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.014479e-01 | 0.096 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.103237e-01 | 0.091 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.123701e-01 | 0.090 |
| R-HSA-1280218 | Adaptive Immune System | 8.157406e-01 | 0.088 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.371903e-01 | 0.077 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.405583e-01 | 0.075 |
| R-HSA-2142753 | Arachidonate metabolism | 8.405583e-01 | 0.075 |
| R-HSA-9609507 | Protein localization | 8.422802e-01 | 0.075 |
| R-HSA-9711097 | Cellular response to starvation | 8.506162e-01 | 0.070 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.540381e-01 | 0.069 |
| R-HSA-388396 | GPCR downstream signalling | 8.600275e-01 | 0.065 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.716985e-01 | 0.060 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.730858e-01 | 0.059 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.744583e-01 | 0.058 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.771590e-01 | 0.057 |
| R-HSA-2559583 | Cellular Senescence | 8.836607e-01 | 0.054 |
| R-HSA-8957322 | Metabolism of steroids | 8.860587e-01 | 0.053 |
| R-HSA-1474244 | Extracellular matrix organization | 8.927530e-01 | 0.049 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.990079e-01 | 0.046 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.025421e-01 | 0.045 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.064198e-01 | 0.043 |
| R-HSA-428157 | Sphingolipid metabolism | 9.074336e-01 | 0.042 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.094284e-01 | 0.041 |
| R-HSA-372790 | Signaling by GPCR | 9.142446e-01 | 0.039 |
| R-HSA-212436 | Generic Transcription Pathway | 9.224853e-01 | 0.035 |
| R-HSA-9748784 | Drug ADME | 9.239222e-01 | 0.034 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.332568e-01 | 0.030 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.339268e-01 | 0.030 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.381664e-01 | 0.028 |
| R-HSA-157118 | Signaling by NOTCH | 9.401590e-01 | 0.027 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.407156e-01 | 0.027 |
| R-HSA-418594 | G alpha (i) signalling events | 9.458364e-01 | 0.024 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.497561e-01 | 0.022 |
| R-HSA-416476 | G alpha (q) signalling events | 9.539641e-01 | 0.020 |
| R-HSA-72766 | Translation | 9.556662e-01 | 0.020 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.617782e-01 | 0.017 |
| R-HSA-9658195 | Leishmania infection | 9.617782e-01 | 0.017 |
| R-HSA-5663205 | Infectious disease | 9.622288e-01 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 9.672119e-01 | 0.014 |
| R-HSA-112316 | Neuronal System | 9.690630e-01 | 0.014 |
| R-HSA-449147 | Signaling by Interleukins | 9.712900e-01 | 0.013 |
| R-HSA-109582 | Hemostasis | 9.754738e-01 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.846314e-01 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.890776e-01 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 9.905370e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.951475e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.975176e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.987452e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999996e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.826 | 0.359 | 1 | 0.831 |
CLK3 |
0.825 | 0.311 | 1 | 0.865 |
KIS |
0.823 | 0.400 | 1 | 0.911 |
HIPK2 |
0.820 | 0.422 | 1 | 0.868 |
CDK18 |
0.819 | 0.425 | 1 | 0.887 |
CDK7 |
0.818 | 0.401 | 1 | 0.912 |
CDK19 |
0.818 | 0.397 | 1 | 0.884 |
DYRK2 |
0.817 | 0.401 | 1 | 0.883 |
JNK2 |
0.816 | 0.445 | 1 | 0.889 |
CDK8 |
0.815 | 0.383 | 1 | 0.893 |
CDK13 |
0.812 | 0.396 | 1 | 0.905 |
SRPK1 |
0.810 | 0.213 | -3 | 0.697 |
NLK |
0.810 | 0.339 | 1 | 0.875 |
HIPK1 |
0.810 | 0.391 | 1 | 0.891 |
ERK5 |
0.809 | 0.245 | 1 | 0.851 |
DYRK4 |
0.809 | 0.394 | 1 | 0.883 |
P38B |
0.809 | 0.419 | 1 | 0.897 |
P38D |
0.808 | 0.436 | 1 | 0.880 |
CDC7 |
0.807 | 0.093 | 1 | 0.694 |
P38G |
0.807 | 0.417 | 1 | 0.853 |
JNK3 |
0.806 | 0.413 | 1 | 0.904 |
CDK17 |
0.806 | 0.398 | 1 | 0.855 |
CDK12 |
0.806 | 0.391 | 1 | 0.892 |
CDK9 |
0.806 | 0.386 | 1 | 0.908 |
ERK1 |
0.806 | 0.391 | 1 | 0.900 |
P38A |
0.806 | 0.400 | 1 | 0.914 |
CLK2 |
0.805 | 0.264 | -3 | 0.682 |
CDK1 |
0.805 | 0.371 | 1 | 0.885 |
MTOR |
0.804 | 0.097 | 1 | 0.742 |
CDK5 |
0.803 | 0.371 | 1 | 0.911 |
CDK16 |
0.803 | 0.397 | 1 | 0.867 |
CDK10 |
0.802 | 0.378 | 1 | 0.894 |
DYRK1B |
0.802 | 0.378 | 1 | 0.885 |
PRKD1 |
0.802 | 0.102 | -3 | 0.782 |
HIPK3 |
0.801 | 0.380 | 1 | 0.878 |
COT |
0.800 | -0.070 | 2 | 0.678 |
CDKL5 |
0.799 | 0.117 | -3 | 0.739 |
CDK3 |
0.798 | 0.343 | 1 | 0.869 |
MOS |
0.798 | 0.049 | 1 | 0.738 |
PRKD2 |
0.797 | 0.083 | -3 | 0.714 |
DYRK1A |
0.797 | 0.311 | 1 | 0.900 |
CDK14 |
0.797 | 0.376 | 1 | 0.896 |
PIM3 |
0.797 | 0.025 | -3 | 0.777 |
ICK |
0.796 | 0.182 | -3 | 0.786 |
PRPK |
0.796 | -0.013 | -1 | 0.649 |
CLK1 |
0.796 | 0.227 | -3 | 0.676 |
SRPK2 |
0.795 | 0.151 | -3 | 0.613 |
CLK4 |
0.795 | 0.206 | -3 | 0.703 |
CDKL1 |
0.793 | 0.059 | -3 | 0.746 |
AURC |
0.793 | 0.087 | -2 | 0.669 |
ERK2 |
0.792 | 0.350 | 1 | 0.903 |
DYRK3 |
0.792 | 0.297 | 1 | 0.866 |
CHAK2 |
0.791 | 0.073 | -1 | 0.644 |
CAMK1B |
0.791 | -0.000 | -3 | 0.801 |
NDR2 |
0.790 | -0.038 | -3 | 0.785 |
ATR |
0.789 | 0.024 | 1 | 0.680 |
RAF1 |
0.789 | -0.086 | 1 | 0.666 |
IKKB |
0.789 | -0.106 | -2 | 0.750 |
WNK1 |
0.788 | 0.006 | -2 | 0.883 |
PDHK4 |
0.788 | -0.131 | 1 | 0.712 |
PIM1 |
0.788 | 0.042 | -3 | 0.723 |
SKMLCK |
0.788 | 0.022 | -2 | 0.856 |
NUAK2 |
0.788 | 0.028 | -3 | 0.777 |
RSK2 |
0.787 | 0.022 | -3 | 0.712 |
AMPKA1 |
0.787 | 0.045 | -3 | 0.796 |
NEK6 |
0.786 | -0.010 | -2 | 0.782 |
TBK1 |
0.786 | -0.090 | 1 | 0.584 |
MAK |
0.786 | 0.288 | -2 | 0.746 |
MST4 |
0.785 | -0.015 | 2 | 0.693 |
JNK1 |
0.785 | 0.355 | 1 | 0.880 |
PRP4 |
0.785 | 0.260 | -3 | 0.802 |
AMPKA2 |
0.784 | 0.055 | -3 | 0.760 |
SRPK3 |
0.784 | 0.123 | -3 | 0.664 |
DSTYK |
0.784 | -0.093 | 2 | 0.704 |
BMPR2 |
0.783 | -0.166 | -2 | 0.823 |
MARK4 |
0.783 | 0.005 | 4 | 0.820 |
PDHK1 |
0.783 | -0.088 | 1 | 0.684 |
MAPKAPK3 |
0.783 | 0.002 | -3 | 0.720 |
NIK |
0.783 | -0.027 | -3 | 0.827 |
RSK3 |
0.783 | 0.010 | -3 | 0.700 |
CAMK2G |
0.783 | -0.109 | 2 | 0.635 |
CAMLCK |
0.783 | 0.013 | -2 | 0.839 |
NDR1 |
0.782 | -0.036 | -3 | 0.775 |
P90RSK |
0.782 | -0.002 | -3 | 0.716 |
ULK2 |
0.782 | -0.129 | 2 | 0.590 |
DAPK2 |
0.781 | 0.007 | -3 | 0.813 |
CDK2 |
0.781 | 0.236 | 1 | 0.873 |
IKKE |
0.781 | -0.115 | 1 | 0.574 |
MOK |
0.780 | 0.292 | 1 | 0.858 |
HUNK |
0.780 | -0.054 | 2 | 0.622 |
CAMK2D |
0.780 | -0.046 | -3 | 0.787 |
GCN2 |
0.780 | -0.206 | 2 | 0.614 |
PKACG |
0.780 | 0.008 | -2 | 0.737 |
P70S6KB |
0.780 | 0.001 | -3 | 0.730 |
CDK4 |
0.780 | 0.365 | 1 | 0.885 |
FAM20C |
0.779 | 0.007 | 2 | 0.512 |
MAPKAPK2 |
0.779 | 0.001 | -3 | 0.671 |
CDK6 |
0.779 | 0.349 | 1 | 0.896 |
MNK2 |
0.779 | 0.026 | -2 | 0.802 |
TSSK2 |
0.778 | 0.005 | -5 | 0.846 |
ERK7 |
0.778 | 0.137 | 2 | 0.442 |
PKN3 |
0.778 | -0.061 | -3 | 0.762 |
PAK1 |
0.778 | 0.007 | -2 | 0.795 |
TSSK1 |
0.778 | 0.019 | -3 | 0.816 |
RIPK3 |
0.777 | -0.112 | 3 | 0.713 |
IKKA |
0.777 | -0.075 | -2 | 0.732 |
PRKD3 |
0.777 | 0.030 | -3 | 0.680 |
PKN2 |
0.777 | -0.054 | -3 | 0.783 |
NEK7 |
0.776 | -0.125 | -3 | 0.836 |
PAK3 |
0.776 | -0.008 | -2 | 0.798 |
GRK1 |
0.776 | -0.041 | -2 | 0.756 |
PKACB |
0.776 | 0.050 | -2 | 0.680 |
MLK2 |
0.775 | -0.063 | 2 | 0.649 |
BCKDK |
0.775 | -0.138 | -1 | 0.581 |
PAK6 |
0.775 | 0.036 | -2 | 0.739 |
PKCD |
0.775 | -0.029 | 2 | 0.602 |
NIM1 |
0.774 | -0.049 | 3 | 0.746 |
DNAPK |
0.774 | 0.018 | 1 | 0.584 |
NEK9 |
0.773 | -0.094 | 2 | 0.642 |
LATS2 |
0.773 | -0.061 | -5 | 0.732 |
BMPR1B |
0.773 | 0.014 | 1 | 0.632 |
ULK1 |
0.772 | -0.144 | -3 | 0.799 |
CAMK2A |
0.772 | -0.033 | 2 | 0.639 |
GRK5 |
0.772 | -0.170 | -3 | 0.821 |
AURB |
0.772 | 0.033 | -2 | 0.664 |
IRE1 |
0.772 | -0.047 | 1 | 0.626 |
SMG1 |
0.771 | -0.022 | 1 | 0.639 |
PRKX |
0.771 | 0.052 | -3 | 0.610 |
QSK |
0.771 | 0.009 | 4 | 0.795 |
MLK1 |
0.771 | -0.173 | 2 | 0.626 |
NEK2 |
0.771 | -0.012 | 2 | 0.642 |
AKT2 |
0.770 | 0.035 | -3 | 0.621 |
MASTL |
0.770 | -0.183 | -2 | 0.786 |
PKCB |
0.770 | -0.015 | 2 | 0.561 |
RSK4 |
0.770 | 0.003 | -3 | 0.676 |
WNK3 |
0.769 | -0.212 | 1 | 0.641 |
CAMK2B |
0.769 | -0.063 | 2 | 0.620 |
PIM2 |
0.769 | 0.040 | -3 | 0.677 |
MELK |
0.769 | -0.050 | -3 | 0.742 |
MNK1 |
0.768 | -0.003 | -2 | 0.805 |
NUAK1 |
0.768 | -0.025 | -3 | 0.716 |
PKCZ |
0.768 | -0.014 | 2 | 0.601 |
ATM |
0.768 | -0.070 | 1 | 0.618 |
MSK2 |
0.768 | -0.045 | -3 | 0.690 |
GRK6 |
0.768 | -0.130 | 1 | 0.650 |
MSK1 |
0.767 | -0.009 | -3 | 0.690 |
TGFBR2 |
0.767 | -0.134 | -2 | 0.689 |
PHKG1 |
0.767 | -0.050 | -3 | 0.769 |
SGK3 |
0.767 | 0.018 | -3 | 0.700 |
RIPK1 |
0.767 | -0.190 | 1 | 0.631 |
PKG2 |
0.766 | 0.013 | -2 | 0.684 |
QIK |
0.766 | -0.067 | -3 | 0.773 |
PKR |
0.766 | -0.068 | 1 | 0.667 |
DLK |
0.766 | -0.224 | 1 | 0.647 |
MLK3 |
0.765 | -0.102 | 2 | 0.576 |
PKCA |
0.765 | -0.031 | 2 | 0.557 |
LKB1 |
0.765 | 0.158 | -3 | 0.823 |
PINK1 |
0.765 | 0.058 | 1 | 0.777 |
PKCG |
0.765 | -0.050 | 2 | 0.566 |
ALK4 |
0.765 | -0.059 | -2 | 0.759 |
LATS1 |
0.765 | -0.049 | -3 | 0.803 |
CAMK4 |
0.765 | -0.108 | -3 | 0.753 |
GSK3A |
0.765 | 0.110 | 4 | 0.482 |
PAK2 |
0.764 | -0.038 | -2 | 0.780 |
BRSK1 |
0.764 | -0.041 | -3 | 0.724 |
SIK |
0.764 | -0.020 | -3 | 0.691 |
VRK2 |
0.764 | -0.054 | 1 | 0.737 |
MPSK1 |
0.764 | 0.079 | 1 | 0.696 |
TGFBR1 |
0.764 | -0.049 | -2 | 0.725 |
MYLK4 |
0.764 | -0.021 | -2 | 0.776 |
CHK1 |
0.763 | -0.037 | -3 | 0.760 |
ANKRD3 |
0.763 | -0.207 | 1 | 0.675 |
CHAK1 |
0.763 | -0.069 | 2 | 0.647 |
MARK3 |
0.762 | -0.009 | 4 | 0.750 |
BRSK2 |
0.762 | -0.054 | -3 | 0.751 |
GRK7 |
0.762 | -0.030 | 1 | 0.635 |
MEK1 |
0.762 | -0.129 | 2 | 0.668 |
TTBK2 |
0.761 | -0.178 | 2 | 0.543 |
DCAMKL1 |
0.761 | -0.027 | -3 | 0.723 |
YSK4 |
0.760 | -0.142 | 1 | 0.610 |
BUB1 |
0.760 | 0.139 | -5 | 0.810 |
PKACA |
0.759 | 0.029 | -2 | 0.634 |
AURA |
0.759 | -0.007 | -2 | 0.629 |
IRE2 |
0.759 | -0.083 | 2 | 0.541 |
MAPKAPK5 |
0.758 | -0.078 | -3 | 0.666 |
MST3 |
0.758 | -0.014 | 2 | 0.677 |
GSK3B |
0.758 | 0.040 | 4 | 0.475 |
TLK2 |
0.758 | -0.074 | 1 | 0.599 |
PKCH |
0.757 | -0.068 | 2 | 0.533 |
GRK4 |
0.757 | -0.202 | -2 | 0.752 |
MARK2 |
0.757 | -0.035 | 4 | 0.721 |
AKT1 |
0.756 | 0.015 | -3 | 0.642 |
ALK2 |
0.756 | -0.073 | -2 | 0.728 |
NEK5 |
0.756 | -0.041 | 1 | 0.658 |
WNK4 |
0.756 | -0.059 | -2 | 0.870 |
CK1E |
0.756 | -0.011 | -3 | 0.578 |
SSTK |
0.756 | -0.009 | 4 | 0.782 |
CAMK1G |
0.755 | -0.066 | -3 | 0.691 |
PLK1 |
0.754 | -0.178 | -2 | 0.713 |
ACVR2B |
0.754 | -0.088 | -2 | 0.699 |
PKCI |
0.753 | -0.015 | 2 | 0.567 |
SBK |
0.753 | 0.069 | -3 | 0.503 |
CAMKK2 |
0.753 | 0.024 | -2 | 0.775 |
MLK4 |
0.753 | -0.157 | 2 | 0.547 |
PAK5 |
0.753 | -0.004 | -2 | 0.671 |
P70S6K |
0.752 | -0.033 | -3 | 0.640 |
SNRK |
0.752 | -0.159 | 2 | 0.511 |
MARK1 |
0.752 | -0.059 | 4 | 0.764 |
PKCT |
0.752 | -0.041 | 2 | 0.540 |
GAK |
0.751 | 0.010 | 1 | 0.740 |
PLK4 |
0.751 | -0.133 | 2 | 0.457 |
TAO3 |
0.750 | -0.061 | 1 | 0.647 |
PAK4 |
0.750 | -0.002 | -2 | 0.669 |
BRAF |
0.750 | -0.116 | -4 | 0.743 |
ACVR2A |
0.750 | -0.115 | -2 | 0.682 |
IRAK4 |
0.750 | -0.101 | 1 | 0.625 |
DRAK1 |
0.750 | -0.150 | 1 | 0.590 |
MEK5 |
0.750 | -0.179 | 2 | 0.641 |
PBK |
0.750 | 0.095 | 1 | 0.697 |
DCAMKL2 |
0.750 | -0.073 | -3 | 0.741 |
PASK |
0.750 | -0.075 | -3 | 0.803 |
PLK3 |
0.749 | -0.151 | 2 | 0.597 |
CK1D |
0.749 | 0.005 | -3 | 0.532 |
BMPR1A |
0.749 | -0.043 | 1 | 0.610 |
SMMLCK |
0.749 | -0.048 | -3 | 0.754 |
AKT3 |
0.749 | 0.027 | -3 | 0.567 |
CAMKK1 |
0.749 | -0.068 | -2 | 0.777 |
NEK4 |
0.747 | -0.004 | 1 | 0.619 |
CAMK1D |
0.747 | -0.032 | -3 | 0.606 |
PERK |
0.747 | -0.163 | -2 | 0.743 |
PKCE |
0.747 | -0.010 | 2 | 0.554 |
PHKG2 |
0.747 | -0.078 | -3 | 0.728 |
MEKK2 |
0.746 | -0.136 | 2 | 0.610 |
GRK2 |
0.746 | -0.108 | -2 | 0.661 |
SGK1 |
0.746 | 0.029 | -3 | 0.545 |
CK1G1 |
0.746 | -0.028 | -3 | 0.564 |
HRI |
0.746 | -0.196 | -2 | 0.762 |
ZAK |
0.745 | -0.180 | 1 | 0.597 |
MEKK6 |
0.745 | -0.021 | 1 | 0.633 |
NEK11 |
0.745 | -0.110 | 1 | 0.633 |
DAPK3 |
0.745 | -0.011 | -3 | 0.735 |
TNIK |
0.745 | 0.014 | 3 | 0.832 |
MEKK1 |
0.744 | -0.190 | 1 | 0.634 |
HGK |
0.744 | -0.001 | 3 | 0.829 |
HPK1 |
0.744 | -0.009 | 1 | 0.624 |
CK1A2 |
0.744 | -0.015 | -3 | 0.528 |
TLK1 |
0.743 | -0.142 | -2 | 0.738 |
NEK1 |
0.743 | 0.017 | 1 | 0.627 |
GCK |
0.743 | -0.044 | 1 | 0.633 |
TAO2 |
0.743 | -0.083 | 2 | 0.663 |
MEKK3 |
0.742 | -0.225 | 1 | 0.632 |
PKN1 |
0.742 | -0.031 | -3 | 0.660 |
PDK1 |
0.741 | -0.075 | 1 | 0.660 |
MRCKB |
0.741 | 0.014 | -3 | 0.665 |
MAP3K15 |
0.740 | -0.066 | 1 | 0.605 |
CK2A2 |
0.740 | -0.052 | 1 | 0.576 |
ROCK2 |
0.740 | 0.025 | -3 | 0.724 |
LOK |
0.740 | -0.030 | -2 | 0.759 |
KHS1 |
0.740 | 0.010 | 1 | 0.620 |
CHK2 |
0.739 | -0.020 | -3 | 0.567 |
NEK8 |
0.739 | -0.164 | 2 | 0.628 |
KHS2 |
0.739 | 0.022 | 1 | 0.630 |
MINK |
0.739 | -0.050 | 1 | 0.619 |
LRRK2 |
0.739 | -0.068 | 2 | 0.663 |
DAPK1 |
0.738 | -0.025 | -3 | 0.719 |
MRCKA |
0.737 | 0.000 | -3 | 0.682 |
CAMK1A |
0.736 | -0.026 | -3 | 0.583 |
TTBK1 |
0.736 | -0.172 | 2 | 0.475 |
EEF2K |
0.735 | -0.066 | 3 | 0.788 |
MST2 |
0.734 | -0.141 | 1 | 0.634 |
DMPK1 |
0.734 | 0.043 | -3 | 0.689 |
PDHK3_TYR |
0.734 | 0.162 | 4 | 0.874 |
IRAK1 |
0.734 | -0.235 | -1 | 0.555 |
STK33 |
0.733 | -0.112 | 2 | 0.482 |
TAK1 |
0.733 | -0.160 | 1 | 0.637 |
SLK |
0.732 | -0.074 | -2 | 0.697 |
CRIK |
0.732 | 0.031 | -3 | 0.641 |
CK2A1 |
0.731 | -0.057 | 1 | 0.553 |
GRK3 |
0.731 | -0.107 | -2 | 0.613 |
YSK1 |
0.730 | -0.071 | 2 | 0.628 |
HASPIN |
0.730 | -0.018 | -1 | 0.539 |
NEK3 |
0.730 | -0.050 | 1 | 0.610 |
LIMK2_TYR |
0.728 | 0.162 | -3 | 0.851 |
BIKE |
0.727 | 0.040 | 1 | 0.679 |
PKG1 |
0.727 | -0.023 | -2 | 0.610 |
VRK1 |
0.726 | -0.191 | 2 | 0.623 |
MST1 |
0.725 | -0.152 | 1 | 0.614 |
ROCK1 |
0.725 | 0.003 | -3 | 0.684 |
TESK1_TYR |
0.725 | 0.029 | 3 | 0.846 |
PLK2 |
0.725 | -0.106 | -3 | 0.746 |
MYO3B |
0.724 | -0.007 | 2 | 0.663 |
MEK2 |
0.724 | -0.168 | 2 | 0.629 |
PKMYT1_TYR |
0.723 | 0.083 | 3 | 0.821 |
MAP2K4_TYR |
0.723 | 0.032 | -1 | 0.644 |
PDHK4_TYR |
0.722 | -0.014 | 2 | 0.711 |
MAP2K6_TYR |
0.720 | -0.024 | -1 | 0.649 |
AAK1 |
0.718 | 0.074 | 1 | 0.624 |
YANK3 |
0.718 | -0.062 | 2 | 0.334 |
OSR1 |
0.718 | -0.100 | 2 | 0.631 |
MAP2K7_TYR |
0.717 | -0.123 | 2 | 0.678 |
RIPK2 |
0.717 | -0.250 | 1 | 0.573 |
ASK1 |
0.716 | -0.120 | 1 | 0.598 |
BMPR2_TYR |
0.714 | -0.082 | -1 | 0.630 |
TAO1 |
0.713 | -0.089 | 1 | 0.578 |
PDHK1_TYR |
0.713 | -0.121 | -1 | 0.635 |
CK1A |
0.712 | -0.024 | -3 | 0.447 |
LIMK1_TYR |
0.712 | -0.044 | 2 | 0.668 |
PINK1_TYR |
0.711 | -0.172 | 1 | 0.702 |
EPHA6 |
0.710 | -0.078 | -1 | 0.618 |
MYO3A |
0.710 | -0.094 | 1 | 0.607 |
RET |
0.709 | -0.102 | 1 | 0.644 |
EPHB4 |
0.709 | -0.101 | -1 | 0.595 |
ALPHAK3 |
0.708 | -0.101 | -1 | 0.584 |
TTK |
0.708 | -0.129 | -2 | 0.713 |
MST1R |
0.707 | -0.111 | 3 | 0.783 |
ABL2 |
0.707 | -0.045 | -1 | 0.578 |
TNK2 |
0.707 | -0.026 | 3 | 0.731 |
DDR1 |
0.706 | -0.085 | 4 | 0.791 |
TNNI3K_TYR |
0.705 | 0.068 | 1 | 0.651 |
NEK10_TYR |
0.705 | -0.010 | 1 | 0.573 |
TYK2 |
0.704 | -0.117 | 1 | 0.639 |
JAK2 |
0.704 | -0.078 | 1 | 0.646 |
ABL1 |
0.704 | -0.054 | -1 | 0.570 |
TYRO3 |
0.703 | -0.139 | 3 | 0.760 |
ROS1 |
0.703 | -0.097 | 3 | 0.733 |
CSF1R |
0.701 | -0.108 | 3 | 0.764 |
JAK1 |
0.700 | 0.015 | 1 | 0.594 |
JAK3 |
0.700 | -0.121 | 1 | 0.633 |
TNK1 |
0.699 | -0.045 | 3 | 0.750 |
EPHA4 |
0.699 | -0.108 | 2 | 0.619 |
TXK |
0.698 | -0.095 | 1 | 0.657 |
FGR |
0.698 | -0.122 | 1 | 0.687 |
LCK |
0.697 | -0.062 | -1 | 0.571 |
FER |
0.697 | -0.157 | 1 | 0.694 |
BLK |
0.696 | -0.054 | -1 | 0.570 |
YES1 |
0.696 | -0.136 | -1 | 0.573 |
FGFR2 |
0.696 | -0.132 | 3 | 0.762 |
HCK |
0.695 | -0.134 | -1 | 0.567 |
EPHB3 |
0.695 | -0.146 | -1 | 0.582 |
EPHB1 |
0.695 | -0.153 | 1 | 0.654 |
STLK3 |
0.695 | -0.195 | 1 | 0.569 |
SRMS |
0.695 | -0.157 | 1 | 0.661 |
MERTK |
0.694 | -0.118 | 3 | 0.750 |
INSRR |
0.694 | -0.149 | 3 | 0.703 |
AXL |
0.693 | -0.135 | 3 | 0.746 |
ITK |
0.693 | -0.149 | -1 | 0.557 |
FGFR1 |
0.692 | -0.119 | 3 | 0.730 |
EPHB2 |
0.692 | -0.157 | -1 | 0.573 |
KIT |
0.692 | -0.147 | 3 | 0.766 |
KDR |
0.691 | -0.129 | 3 | 0.727 |
TEK |
0.690 | -0.135 | 3 | 0.696 |
BMX |
0.690 | -0.122 | -1 | 0.511 |
PDGFRB |
0.689 | -0.196 | 3 | 0.769 |
WEE1_TYR |
0.689 | -0.113 | -1 | 0.556 |
PTK2B |
0.686 | -0.092 | -1 | 0.551 |
MET |
0.686 | -0.142 | 3 | 0.757 |
LTK |
0.686 | -0.136 | 3 | 0.704 |
EPHA3 |
0.686 | -0.167 | 2 | 0.587 |
EPHA7 |
0.686 | -0.149 | 2 | 0.610 |
DDR2 |
0.685 | -0.033 | 3 | 0.689 |
FLT3 |
0.685 | -0.205 | 3 | 0.765 |
ALK |
0.685 | -0.133 | 3 | 0.673 |
CK1G3 |
0.684 | -0.051 | -3 | 0.398 |
PDGFRA |
0.684 | -0.205 | 3 | 0.765 |
EPHA1 |
0.684 | -0.150 | 3 | 0.744 |
FYN |
0.684 | -0.116 | -1 | 0.541 |
YANK2 |
0.683 | -0.079 | 2 | 0.343 |
TEC |
0.683 | -0.182 | -1 | 0.510 |
PTK6 |
0.683 | -0.187 | -1 | 0.520 |
FGFR3 |
0.682 | -0.162 | 3 | 0.730 |
BTK |
0.682 | -0.243 | -1 | 0.526 |
INSR |
0.680 | -0.155 | 3 | 0.685 |
EPHA5 |
0.679 | -0.165 | 2 | 0.594 |
LYN |
0.678 | -0.158 | 3 | 0.687 |
ERBB2 |
0.678 | -0.200 | 1 | 0.596 |
FRK |
0.678 | -0.180 | -1 | 0.581 |
NTRK1 |
0.678 | -0.240 | -1 | 0.578 |
FLT1 |
0.678 | -0.209 | -1 | 0.583 |
MATK |
0.677 | -0.140 | -1 | 0.531 |
FLT4 |
0.677 | -0.213 | 3 | 0.720 |
NTRK3 |
0.676 | -0.163 | -1 | 0.552 |
PTK2 |
0.675 | -0.102 | -1 | 0.546 |
NTRK2 |
0.674 | -0.234 | 3 | 0.714 |
CSK |
0.674 | -0.166 | 2 | 0.613 |
EPHA8 |
0.674 | -0.165 | -1 | 0.557 |
EGFR |
0.672 | -0.144 | 1 | 0.518 |
SRC |
0.672 | -0.156 | -1 | 0.535 |
FGFR4 |
0.669 | -0.155 | -1 | 0.547 |
SYK |
0.668 | -0.123 | -1 | 0.544 |
MUSK |
0.666 | -0.156 | 1 | 0.516 |
EPHA2 |
0.666 | -0.169 | -1 | 0.533 |
IGF1R |
0.662 | -0.171 | 3 | 0.622 |
CK1G2 |
0.662 | -0.072 | -3 | 0.486 |
ERBB4 |
0.660 | -0.133 | 1 | 0.533 |
ZAP70 |
0.657 | -0.079 | -1 | 0.514 |
FES |
0.649 | -0.181 | -1 | 0.492 |