Motif 154 (n=200)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S99 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0A087X0R7 | SENP3-EIF4A1 | S111 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0A096LP49 | CCDC187 | S1027 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A0A0C4DFX4 | None | S543 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0C4DFX4 | None | S2253 | ochoa | Snf2 related CREBBP activator protein | None |
| A2A288 | ZC3H12D | S428 | ochoa | Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) | May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}. |
| A5PL33 | KRBA1 | S498 | ochoa | Protein KRBA1 | None |
| A8K855 | EFCAB7 | S200 | ochoa | EF-hand calcium-binding domain-containing protein 7 | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}. |
| A8MYZ6 | FOXO6 | S210 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| K7ELQ4 | ATF7-NPFF | S304 | ochoa | ATF7-NPFF readthrough | None |
| O00409 | FOXN3 | S85 | ochoa|psp | Forkhead box protein N3 (Checkpoint suppressor 1) | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. |
| O00512 | BCL9 | S878 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14686 | KMT2D | S3130 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15061 | SYNM | S1181 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15164 | TRIM24 | S660 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15265 | ATXN7 | S302 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O15297 | PPM1D | S40 | ochoa | Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) | Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23242139}. |
| O15375 | SLC16A5 | S451 | ochoa | Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5) | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}. |
| O15534 | PER1 | S592 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43426 | SYNJ1 | S1178 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43521 | BCL2L11 | S59 | psp | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}. |
| O60292 | SIPA1L3 | S1144 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75385 | ULK1 | S758 | ochoa|psp | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O76074 | PDE5A | S86 | ochoa | cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}. |
| O95267 | RASGRP1 | S694 | ochoa | RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) | Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:23908768, ECO:0000269|PubMed:27776107, ECO:0000269|PubMed:29155103}. |
| O95359 | TACC2 | S1768 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95873 | C6orf47 | S131 | ochoa | Uncharacterized protein C6orf47 (Protein G4) | None |
| P03372 | ESR1 | S106 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04626 | ERBB2 | Y1139 | psp | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05408 | SCG5 | S108 | ochoa | Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}. |
| P06401 | PGR | S190 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P09884 | POLA1 | S209 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P13196 | ALAS1 | S85 | ochoa | 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. {ECO:0000269|PubMed:16234850, ECO:0000269|PubMed:17975826}. |
| P14635 | CCNB1 | S116 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P15056 | BRAF | S335 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P18433 | PTPRA | S211 | ochoa | Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:P18052}. |
| P19174 | PLCG1 | S866 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P22314 | UBA1 | S24 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23443 | RPS6KB1 | S434 | psp | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P26651 | ZFP36 | S296 | psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P27986 | PIK3R1 | S83 | psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P27987 | ITPKB | S355 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P28360 | MSX1 | S136 | ochoa | Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) | Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). {ECO:0000250|UniProtKB:P13297, ECO:0000269|PubMed:12807959, ECO:0000303|PubMed:8696335}. |
| P29353 | SHC1 | S36 | psp | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P32927 | CSF2RB | S601 | ochoa|psp | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P35712 | SOX6 | S454 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P37275 | ZEB1 | S679 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P42694 | HELZ | S1463 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P48681 | NES | S346 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49796 | RGS3 | S704 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50548 | ERF | S327 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P51617 | IRAK1 | S163 | psp | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P51825 | AFF1 | S199 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52735 | VAV2 | S576 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P57721 | PCBP3 | S201 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P78356 | PIP4K2B | S326 | ochoa|psp | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}. |
| P78411 | IRX5 | S274 | ochoa | Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) | Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}. |
| P78559 | MAP1A | S2617 | ochoa|psp | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01543 | FLI1 | S39 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q04759 | PRKCQ | S323 | ochoa | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q06413 | MEF2C | S228 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q08050 | FOXM1 | S638 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12765 | SCRN1 | S322 | ochoa | Secernin-1 | Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). {ECO:0000250}. |
| Q12770 | SCAP | S851 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12774 | ARHGEF5 | S983 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12815 | TROAP | S98 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12888 | TP53BP1 | S452 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13202 | DUSP8 | S322 | ochoa | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) | Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues. {ECO:0000250|UniProtKB:O09112}. |
| Q13285 | NR5A1 | S203 | psp | Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250|UniProtKB:P33242, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:27378692, ECO:0000269|PubMed:28459839}. |
| Q13625 | TP53BP2 | S576 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q15366 | PCBP2 | S173 | ochoa|psp | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15633 | TARBP2 | S142 | ochoa|psp | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}. |
| Q15942 | ZYX | S202 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16204 | CCDC6 | S419 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16254 | E2F4 | S218 | ochoa | Transcription factor E2F4 (E2F-4) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Q27J81 | INF2 | S1083 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2VPK5 | CTU2 | S419 | ochoa | Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2) | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}. |
| Q53ET0 | CRTC2 | S183 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5JRA6 | MIA3 | S1678 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JTD0 | TJAP1 | S449 | ochoa | Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) | Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}. |
| Q5JWF2 | GNAS | S532 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5SXM2 | SNAPC4 | S626 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5T1V6 | DDX59 | S64 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5T481 | RBM20 | S1048 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5T8A7 | PPP1R26 | S1132 | ochoa | Protein phosphatase 1 regulatory subunit 26 | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}. |
| Q5VT06 | CEP350 | S1818 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q63HR2 | TNS2 | S481 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q63HR2 | TNS2 | S1247 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68CZ2 | TNS3 | S811 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68DA7 | FMN1 | S518 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q68DK7 | MSL1 | S161 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q68EM7 | ARHGAP17 | S625 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YH5 | CDCA2 | S309 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YN4 | VIRMA | S138 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6IBW4 | NCAPH2 | S232 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6NV74 | CRACDL | S609 | ochoa | CRACD-like protein | None |
| Q6NZ36 | FAAP20 | S113 | ochoa|psp | Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa) | Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22396592, ECO:0000269|PubMed:22705371}. |
| Q6PJI9 | WDR59 | S756 | ochoa | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}. |
| Q6PJT7 | ZC3H14 | S515 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6UB99 | ANKRD11 | S1847 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWD8 | C16orf54 | S184 | ochoa | Transmembrane protein C16orf54 | None |
| Q6UXY1 | BAIAP2L2 | S231 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6ZMD2 | SPNS3 | S21 | ochoa | Protein spinster homolog 3 | Sphingolipid transporter. {ECO:0000250}. |
| Q6ZNL6 | FGD5 | S744 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZRS2 | SRCAP | S562 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRS2 | SRCAP | S2430 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZTI6 | RFLNA | S25 | ochoa | Refilin-A (Regulator of filamin protein A) (RefilinA) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}. |
| Q6ZUS6 | CCDC149 | S414 | ochoa | Coiled-coil domain-containing protein 149 | None |
| Q70EL1 | USP54 | S632 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q76N32 | CEP68 | S435 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7Z2Z1 | TICRR | S1430 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q86U44 | METTL3 | S43 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86U44 | METTL3 | S50 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86WR7 | PROSER2 | S312 | ochoa | Proline and serine-rich protein 2 | None |
| Q86YV5 | PRAG1 | S782 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVF2 | AHNAK2 | S4894 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S5515 | ochoa | Protein AHNAK2 | None |
| Q8IVH8 | MAP4K3 | S467 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q8IVL1 | NAV2 | S1302 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWU2 | LMTK2 | S1124 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWY9 | CDAN1 | S265 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
| Q8IX01 | SUGP2 | S745 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IX07 | ZFPM1 | S44 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXI1 | RHOT2 | S538 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IY33 | MICALL2 | S318 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8N1G0 | ZNF687 | S183 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N2Y8 | RUSC2 | S1368 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N699 | MYCT1 | S212 | ochoa | Myc target protein 1 (Myc target in myeloid cells protein 1) | May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}. |
| Q8N961 | ABTB2 | S365 | ochoa | Ankyrin repeat and BTB/POZ domain-containing protein 2 | May be involved in the initiation of hepatocyte growth. {ECO:0000250}. |
| Q8NFI3 | ENGASE | S673 | ochoa | Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) | Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}. |
| Q8NFU0 | BEST4 | S397 | ochoa | Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985). {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}. |
| Q8TBC5 | ZSCAN18 | S168 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TBE0 | BAHD1 | S101 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TD26 | CHD6 | S2680 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TE68 | EPS8L1 | S545 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TEH3 | DENND1A | S546 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8WUI4 | HDAC7 | S283 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WUM4 | PDCD6IP | S712 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WX92 | NELFB | S557 | ochoa | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
| Q8WXD9 | CASKIN1 | S1242 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q92545 | TMEM131 | S1363 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92545 | TMEM131 | S1495 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92766 | RREB1 | S36 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92859 | NEO1 | S1178 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q92918 | MAP4K1 | S737 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92934 | BAD | S91 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q93074 | MED12 | S688 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96DN6 | MBD6 | S975 | ochoa | Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6) | Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth (PubMed:36180891). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:36180891}. |
| Q96I24 | FUBP3 | S296 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96RG2 | PASK | S524 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96S66 | CLCC1 | S532 | ochoa | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q96S90 | LYSMD1 | S194 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q96SI1 | KCTD15 | S35 | ochoa | BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15) | During embryonic development, it is involved in neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain (PubMed:23382213). {ECO:0000250|UniProtKB:Q6DC02, ECO:0000269|PubMed:23382213}. |
| Q99814 | EPAS1 | S790 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q9BR39 | JPH2 | S486 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BT22 | ALG1 | S242 | ochoa | Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1) | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:14973778, ECO:0000269|PubMed:26931382}. |
| Q9BTC0 | DIDO1 | S1650 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BW04 | SARG | S385 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BYB0 | SHANK3 | S435 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZL4 | PPP1R12C | S604 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C073 | FAM117A | S317 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0C4 | SEMA4C | S760 | ochoa | Semaphorin-4C | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}. |
| Q9C0K0 | BCL11B | S169 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9GZN2 | TGIF2 | S174 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
| Q9GZY8 | MFF | S202 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H4L4 | SENP3 | S169 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H4L4 | SENP3 | S181 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H9L7 | AKIRIN1 | S19 | ochoa | Akirin-1 | Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed:34711951). {ECO:0000250|UniProtKB:Q99LF1, ECO:0000269|PubMed:34711951}. |
| Q9HAW0 | BRF2 | S353 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
| Q9HCH0 | NCKAP5L | S470 | psp | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}. |
| Q9HCH5 | SYTL2 | S460 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCS5 | EPB41L4A | S426 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NXL9 | MCM9 | S883 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NZT2 | OGFR | S525 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P1Y5 | CAMSAP3 | S530 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P266 | JCAD | S400 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2S5 | WRAP73 | S281 | ochoa | WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) | The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. |
| Q9UBS0 | RPS6KB2 | S410 | psp | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q9UBW5 | BIN2 | S406 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGU0 | TCF20 | S1418 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UGU0 | TCF20 | S1522 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHB7 | AFF4 | S1043 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJJ7 | RPUSD1 | S271 | ochoa | RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein) | None |
| Q9UK76 | JPT1 | S119 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKK3 | PARP4 | S1434 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UL51 | HCN2 | S754 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULC8 | ZDHHC8 | S725 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULJ3 | ZBTB21 | S981 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULU4 | ZMYND8 | S737 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMN6 | KMT2B | S1836 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UN19 | DAPP1 | S117 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9UQ35 | SRRM2 | S353 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y285 | FARSA | S490 | ochoa | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| Q9Y2I7 | PIKFYVE | S76 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2T1 | AXIN2 | S454 | ochoa | Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. {ECO:0000250|UniProtKB:O15169}. |
| Q9Y3A4 | RRP7A | S99 | ochoa | Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14) | Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:33199730, ECO:0000269|PubMed:34516797}. |
| Q9Y4B5 | MTCL1 | S253 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4I1 | MYO5A | S1452 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
| O95785 | WIZ | S1094 | Sugiyama | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P21333 | FLNA | S1029 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000008 | 5.105 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.000085 | 4.073 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.000045 | 4.348 |
| R-HSA-9842663 | Signaling by LTK | 0.000085 | 4.070 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.000239 | 3.622 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.000337 | 3.473 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.000435 | 3.362 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.001559 | 2.807 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.001584 | 2.800 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.001754 | 2.756 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.001754 | 2.756 |
| R-HSA-2424491 | DAP12 signaling | 0.001754 | 2.756 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.001005 | 2.998 |
| R-HSA-9634597 | GPER1 signaling | 0.001242 | 2.906 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.001584 | 2.800 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.001754 | 2.756 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.001114 | 2.953 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.000823 | 3.085 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.000975 | 3.011 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000609 | 3.215 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.001280 | 2.893 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001569 | 2.804 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001569 | 2.804 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.000897 | 3.047 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.002214 | 2.655 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.002525 | 2.598 |
| R-HSA-166520 | Signaling by NTRKs | 0.002556 | 2.593 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.003311 | 2.480 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.003311 | 2.480 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.003046 | 2.516 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.003046 | 2.516 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.002796 | 2.553 |
| R-HSA-8853659 | RET signaling | 0.003311 | 2.480 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.003414 | 2.467 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.003811 | 2.419 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.003811 | 2.419 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.003591 | 2.445 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.004311 | 2.365 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.004574 | 2.340 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.004526 | 2.344 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.004527 | 2.344 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.004630 | 2.334 |
| R-HSA-201556 | Signaling by ALK | 0.004198 | 2.377 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.005325 | 2.274 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.004820 | 2.317 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.005205 | 2.284 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.005370 | 2.270 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.006040 | 2.219 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.006040 | 2.219 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.006256 | 2.204 |
| R-HSA-2172127 | DAP12 interactions | 0.006428 | 2.192 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.007253 | 2.140 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.008130 | 2.090 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.008130 | 2.090 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.008866 | 2.052 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.008332 | 2.079 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.008866 | 2.052 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.008909 | 2.050 |
| R-HSA-8939211 | ESR-mediated signaling | 0.010839 | 1.965 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.010596 | 1.975 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.010630 | 1.973 |
| R-HSA-162582 | Signal Transduction | 0.010853 | 1.964 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.010596 | 1.975 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.009955 | 2.002 |
| R-HSA-73887 | Death Receptor Signaling | 0.011210 | 1.950 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.012536 | 1.902 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.012536 | 1.902 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.012972 | 1.887 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.013450 | 1.871 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.014489 | 1.839 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.015034 | 1.823 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.016099 | 1.793 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.016755 | 1.776 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.017873 | 1.748 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.017301 | 1.762 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.017873 | 1.748 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.019060 | 1.720 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.019083 | 1.719 |
| R-HSA-190236 | Signaling by FGFR | 0.019270 | 1.715 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.021491 | 1.668 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.021491 | 1.668 |
| R-HSA-4641265 | Repression of WNT target genes | 0.021491 | 1.668 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.019952 | 1.700 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.023011 | 1.638 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.025850 | 1.588 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.026711 | 1.573 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.029493 | 1.530 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.029493 | 1.530 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.028868 | 1.540 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.027786 | 1.556 |
| R-HSA-9607240 | FLT3 Signaling | 0.030444 | 1.517 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.032064 | 1.494 |
| R-HSA-212436 | Generic Transcription Pathway | 0.032403 | 1.489 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.033493 | 1.475 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.033729 | 1.472 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.035385 | 1.451 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.035385 | 1.451 |
| R-HSA-4549380 | Defective ALG1 causes CDG-1k | 0.041055 | 1.387 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.038487 | 1.415 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 0.041055 | 1.387 |
| R-HSA-373752 | Netrin-1 signaling | 0.037191 | 1.430 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.038988 | 1.409 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.036922 | 1.433 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.037221 | 1.429 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.041689 | 1.380 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.041689 | 1.380 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.041689 | 1.380 |
| R-HSA-210993 | Tie2 Signaling | 0.041689 | 1.380 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.041689 | 1.380 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.042549 | 1.371 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.054364 | 1.265 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.054364 | 1.265 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.054364 | 1.265 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.054364 | 1.265 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.054364 | 1.265 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.054364 | 1.265 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.054364 | 1.265 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.054364 | 1.265 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.054364 | 1.265 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.054364 | 1.265 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.054364 | 1.265 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.051858 | 1.285 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.055425 | 1.256 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.059076 | 1.229 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.059076 | 1.229 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.044986 | 1.347 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.044986 | 1.347 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.059076 | 1.229 |
| R-HSA-418597 | G alpha (z) signalling events | 0.059295 | 1.227 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.055425 | 1.256 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.051676 | 1.287 |
| R-HSA-177929 | Signaling by EGFR | 0.061552 | 1.211 |
| R-HSA-9909396 | Circadian clock | 0.058131 | 1.236 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.061552 | 1.211 |
| R-HSA-9834899 | Specification of the neural plate border | 0.044986 | 1.347 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.055425 | 1.256 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.044637 | 1.350 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.046809 | 1.330 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.052855 | 1.277 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.067488 | 1.171 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.067488 | 1.171 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.067488 | 1.171 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.067488 | 1.171 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.067488 | 1.171 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.080432 | 1.095 |
| R-HSA-1296061 | HCN channels | 0.080432 | 1.095 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.080432 | 1.095 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.093196 | 1.031 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.105784 | 0.976 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.105784 | 0.976 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.105784 | 0.976 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.118198 | 0.927 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.118198 | 0.927 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.130441 | 0.885 |
| R-HSA-8849473 | PTK6 Expression | 0.130441 | 0.885 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.130441 | 0.885 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.142514 | 0.846 |
| R-HSA-1169092 | Activation of RAS in B cells | 0.142514 | 0.846 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.142514 | 0.846 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.142514 | 0.846 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.142514 | 0.846 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.154421 | 0.811 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.166162 | 0.779 |
| R-HSA-68952 | DNA replication initiation | 0.166162 | 0.779 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.066617 | 1.176 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.189161 | 0.723 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.189161 | 0.723 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.189161 | 0.723 |
| R-HSA-69109 | Leading Strand Synthesis | 0.200423 | 0.698 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.200423 | 0.698 |
| R-HSA-69091 | Polymerase switching | 0.200423 | 0.698 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.200423 | 0.698 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.078483 | 1.105 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.222481 | 0.653 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.222481 | 0.653 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.222481 | 0.653 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.233281 | 0.632 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.233281 | 0.632 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.233281 | 0.632 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.233281 | 0.632 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.233281 | 0.632 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.243933 | 0.613 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.254437 | 0.594 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.254437 | 0.594 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.264795 | 0.577 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.285085 | 0.545 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.285085 | 0.545 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.285085 | 0.545 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.083598 | 1.078 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.295020 | 0.530 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.295020 | 0.530 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.295020 | 0.530 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.295020 | 0.530 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.204946 | 0.688 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.304817 | 0.516 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.233281 | 0.632 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.174813 | 0.757 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.200423 | 0.698 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.233281 | 0.632 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.233281 | 0.632 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.210025 | 0.678 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.108387 | 0.965 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.118198 | 0.927 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.254437 | 0.594 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.251129 | 0.600 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.200423 | 0.698 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.093118 | 1.031 |
| R-HSA-418555 | G alpha (s) signalling events | 0.129271 | 0.888 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.067488 | 1.171 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.105784 | 0.976 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.118198 | 0.927 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.142514 | 0.846 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.189161 | 0.723 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.200423 | 0.698 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.086731 | 1.062 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.243933 | 0.613 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.155165 | 0.809 |
| R-HSA-167044 | Signalling to RAS | 0.304817 | 0.516 |
| R-HSA-170968 | Frs2-mediated activation | 0.211528 | 0.675 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.269823 | 0.569 |
| R-HSA-187687 | Signalling to ERKs | 0.117413 | 0.930 |
| R-HSA-74749 | Signal attenuation | 0.166162 | 0.779 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.264795 | 0.577 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.285085 | 0.545 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.295020 | 0.530 |
| R-HSA-169893 | Prolonged ERK activation events | 0.243933 | 0.613 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.169863 | 0.770 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.150322 | 0.823 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.090942 | 1.041 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.130441 | 0.885 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.130441 | 0.885 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.130441 | 0.885 |
| R-HSA-198203 | PI3K/AKT activation | 0.166162 | 0.779 |
| R-HSA-8851805 | MET activates RAS signaling | 0.200423 | 0.698 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.266461 | 0.574 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.254437 | 0.594 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.211528 | 0.675 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.103947 | 0.983 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.121995 | 0.914 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.200423 | 0.698 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.105784 | 0.976 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.105784 | 0.976 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.130441 | 0.885 |
| R-HSA-170984 | ARMS-mediated activation | 0.154421 | 0.811 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.189161 | 0.723 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.275011 | 0.561 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.304817 | 0.516 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.169863 | 0.770 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.108510 | 0.965 |
| R-HSA-186763 | Downstream signal transduction | 0.095226 | 1.021 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.090949 | 1.041 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.198187 | 0.703 |
| R-HSA-9733709 | Cardiogenesis | 0.103947 | 0.983 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.166162 | 0.779 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.200423 | 0.698 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.078483 | 1.105 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.222481 | 0.653 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.233281 | 0.632 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.233281 | 0.632 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.075913 | 1.120 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.206316 | 0.685 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.117413 | 0.930 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.118198 | 0.927 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.118198 | 0.927 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.154421 | 0.811 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.189161 | 0.723 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.200423 | 0.698 |
| R-HSA-418457 | cGMP effects | 0.222481 | 0.653 |
| R-HSA-202403 | TCR signaling | 0.243706 | 0.613 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.108327 | 0.965 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.121995 | 0.914 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.284774 | 0.545 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.121995 | 0.914 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.065866 | 1.181 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.108387 | 0.965 |
| R-HSA-194138 | Signaling by VEGF | 0.134246 | 0.872 |
| R-HSA-525793 | Myogenesis | 0.074457 | 1.128 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.112876 | 0.947 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.194830 | 0.710 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.245865 | 0.609 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.177742 | 0.750 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.211528 | 0.675 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.233281 | 0.632 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.314479 | 0.502 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.251010 | 0.600 |
| R-HSA-1483255 | PI Metabolism | 0.075254 | 1.123 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.233281 | 0.632 |
| R-HSA-180292 | GAB1 signalosome | 0.275011 | 0.561 |
| R-HSA-445144 | Signal transduction by L1 | 0.295020 | 0.530 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.297335 | 0.527 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.142514 | 0.846 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.211528 | 0.675 |
| R-HSA-354192 | Integrin signaling | 0.103947 | 0.983 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.254437 | 0.594 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.126620 | 0.897 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.132653 | 0.877 |
| R-HSA-186797 | Signaling by PDGF | 0.256159 | 0.591 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.297335 | 0.527 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.230630 | 0.637 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.169863 | 0.770 |
| R-HSA-69206 | G1/S Transition | 0.134246 | 0.872 |
| R-HSA-210990 | PECAM1 interactions | 0.177742 | 0.750 |
| R-HSA-392517 | Rap1 signalling | 0.285085 | 0.545 |
| R-HSA-198753 | ERK/MAPK targets | 0.304817 | 0.516 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.314479 | 0.502 |
| R-HSA-195721 | Signaling by WNT | 0.159789 | 0.796 |
| R-HSA-6806834 | Signaling by MET | 0.126523 | 0.898 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.145512 | 0.837 |
| R-HSA-74160 | Gene expression (Transcription) | 0.090444 | 1.044 |
| R-HSA-418346 | Platelet homeostasis | 0.228976 | 0.640 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.086731 | 1.062 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.200087 | 0.699 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.200423 | 0.698 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.211528 | 0.675 |
| R-HSA-8963896 | HDL assembly | 0.222481 | 0.653 |
| R-HSA-5635838 | Activation of SMO | 0.243933 | 0.613 |
| R-HSA-1266738 | Developmental Biology | 0.265317 | 0.576 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.177742 | 0.750 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.211528 | 0.675 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.264795 | 0.577 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.135992 | 0.866 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.225334 | 0.647 |
| R-HSA-8848021 | Signaling by PTK6 | 0.261310 | 0.583 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.261310 | 0.583 |
| R-HSA-450294 | MAP kinase activation | 0.251010 | 0.600 |
| R-HSA-448424 | Interleukin-17 signaling | 0.297335 | 0.527 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.221288 | 0.655 |
| R-HSA-109581 | Apoptosis | 0.245059 | 0.611 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.112857 | 0.947 |
| R-HSA-9664873 | Pexophagy | 0.166162 | 0.779 |
| R-HSA-373753 | Nephrin family interactions | 0.295020 | 0.530 |
| R-HSA-4086398 | Ca2+ pathway | 0.312708 | 0.505 |
| R-HSA-5357801 | Programmed Cell Death | 0.208391 | 0.681 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.285085 | 0.545 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.230457 | 0.637 |
| R-HSA-8983711 | OAS antiviral response | 0.200423 | 0.698 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.251129 | 0.600 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.189797 | 0.722 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.155352 | 0.809 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.284889 | 0.545 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.245865 | 0.609 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.245865 | 0.609 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.245865 | 0.609 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.245865 | 0.609 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.066617 | 1.176 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.066617 | 1.176 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.078483 | 1.105 |
| R-HSA-9707616 | Heme signaling | 0.256159 | 0.591 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.245865 | 0.609 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.317818 | 0.498 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.317818 | 0.498 |
| R-HSA-69275 | G2/M Transition | 0.322216 | 0.492 |
| R-HSA-4839726 | Chromatin organization | 0.323722 | 0.490 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.324007 | 0.489 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.324007 | 0.489 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.324007 | 0.489 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.324007 | 0.489 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.324007 | 0.489 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.324007 | 0.489 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.328009 | 0.484 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.328499 | 0.483 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.333090 | 0.477 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.338160 | 0.471 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.341086 | 0.467 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.342669 | 0.465 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.342669 | 0.465 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.348264 | 0.458 |
| R-HSA-9833482 | PKR-mediated signaling | 0.348264 | 0.458 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.351807 | 0.454 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.351807 | 0.454 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.351807 | 0.454 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.351807 | 0.454 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.351807 | 0.454 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.351807 | 0.454 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.351807 | 0.454 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.351807 | 0.454 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.351807 | 0.454 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.351807 | 0.454 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.360741 | 0.443 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.360818 | 0.443 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.360818 | 0.443 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.360818 | 0.443 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.368302 | 0.434 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.369705 | 0.432 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.369705 | 0.432 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.369705 | 0.432 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.369705 | 0.432 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.369705 | 0.432 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.369705 | 0.432 |
| R-HSA-264876 | Insulin processing | 0.369705 | 0.432 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.378248 | 0.422 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.378469 | 0.422 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.378469 | 0.422 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.378469 | 0.422 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.378469 | 0.422 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.378469 | 0.422 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.383191 | 0.417 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.387111 | 0.412 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.387111 | 0.412 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.387111 | 0.412 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.387111 | 0.412 |
| R-HSA-9663891 | Selective autophagy | 0.393027 | 0.406 |
| R-HSA-422475 | Axon guidance | 0.394432 | 0.404 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.395634 | 0.403 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.395634 | 0.403 |
| R-HSA-202424 | Downstream TCR signaling | 0.402792 | 0.395 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.402792 | 0.395 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.404039 | 0.394 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.404039 | 0.394 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.404039 | 0.394 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.411662 | 0.385 |
| R-HSA-9658195 | Leishmania infection | 0.411662 | 0.385 |
| R-HSA-1538133 | G0 and Early G1 | 0.412327 | 0.385 |
| R-HSA-69190 | DNA strand elongation | 0.412327 | 0.385 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.412327 | 0.385 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.412327 | 0.385 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.412482 | 0.385 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.417298 | 0.380 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.417298 | 0.380 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.420500 | 0.376 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.420500 | 0.376 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.420500 | 0.376 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.422095 | 0.375 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.428561 | 0.368 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.428561 | 0.368 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.431712 | 0.365 |
| R-HSA-1989781 | PPARA activates gene expression | 0.435378 | 0.361 |
| R-HSA-5673000 | RAF activation | 0.436510 | 0.360 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.436510 | 0.360 |
| R-HSA-5205647 | Mitophagy | 0.436510 | 0.360 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.436510 | 0.360 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.441074 | 0.355 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.442684 | 0.354 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.444348 | 0.352 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.444348 | 0.352 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.444348 | 0.352 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.445766 | 0.351 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.445766 | 0.351 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.446323 | 0.350 |
| R-HSA-1483257 | Phospholipid metabolism | 0.449834 | 0.347 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.450435 | 0.346 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.450435 | 0.346 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.450435 | 0.346 |
| R-HSA-422356 | Regulation of insulin secretion | 0.450435 | 0.346 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.452079 | 0.345 |
| R-HSA-3214847 | HATs acetylate histones | 0.455083 | 0.342 |
| R-HSA-4641257 | Degradation of AXIN | 0.459702 | 0.338 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.459702 | 0.338 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.459702 | 0.338 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.459708 | 0.338 |
| R-HSA-8875878 | MET promotes cell motility | 0.467219 | 0.330 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.467219 | 0.330 |
| R-HSA-9675108 | Nervous system development | 0.467738 | 0.330 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.474632 | 0.324 |
| R-HSA-9648002 | RAS processing | 0.474632 | 0.324 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.474632 | 0.324 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.474843 | 0.323 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.477978 | 0.321 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.481943 | 0.317 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.481943 | 0.317 |
| R-HSA-167169 | HIV Transcription Elongation | 0.481943 | 0.317 |
| R-HSA-202433 | Generation of second messenger molecules | 0.481943 | 0.317 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.486971 | 0.312 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.489152 | 0.311 |
| R-HSA-9694548 | Maturation of spike protein | 0.489152 | 0.311 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.496262 | 0.304 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.496262 | 0.304 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.496262 | 0.304 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.496262 | 0.304 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.496262 | 0.304 |
| R-HSA-189451 | Heme biosynthesis | 0.496262 | 0.304 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.496262 | 0.304 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.500279 | 0.301 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.500279 | 0.301 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.503143 | 0.298 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.503143 | 0.298 |
| R-HSA-165159 | MTOR signalling | 0.503273 | 0.298 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.503273 | 0.298 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.504666 | 0.297 |
| R-HSA-1500931 | Cell-Cell communication | 0.505781 | 0.296 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.509028 | 0.293 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.509028 | 0.293 |
| R-HSA-9710421 | Defective pyroptosis | 0.510187 | 0.292 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.510187 | 0.292 |
| R-HSA-8854214 | TBC/RABGAPs | 0.510187 | 0.292 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.517005 | 0.287 |
| R-HSA-69236 | G1 Phase | 0.517005 | 0.287 |
| R-HSA-5683826 | Surfactant metabolism | 0.517005 | 0.287 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.521963 | 0.282 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.523728 | 0.281 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.523728 | 0.281 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.526224 | 0.279 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.530359 | 0.275 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.530359 | 0.275 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.530359 | 0.275 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.530359 | 0.275 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.530359 | 0.275 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.530359 | 0.275 |
| R-HSA-75153 | Apoptotic execution phase | 0.530359 | 0.275 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.534670 | 0.272 |
| R-HSA-5688426 | Deubiquitination | 0.536633 | 0.270 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.536897 | 0.270 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.536897 | 0.270 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.538854 | 0.269 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.543345 | 0.265 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.543345 | 0.265 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.547144 | 0.262 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.549703 | 0.260 |
| R-HSA-449147 | Signaling by Interleukins | 0.550571 | 0.259 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.555330 | 0.255 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.555330 | 0.255 |
| R-HSA-109704 | PI3K Cascade | 0.555973 | 0.255 |
| R-HSA-9748787 | Azathioprine ADME | 0.555973 | 0.255 |
| R-HSA-388396 | GPCR downstream signalling | 0.556288 | 0.255 |
| R-HSA-68875 | Mitotic Prophase | 0.559383 | 0.252 |
| R-HSA-416476 | G alpha (q) signalling events | 0.561991 | 0.250 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.562157 | 0.250 |
| R-HSA-2514856 | The phototransduction cascade | 0.562157 | 0.250 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.567412 | 0.246 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.567412 | 0.246 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.568254 | 0.245 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.568254 | 0.245 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.568254 | 0.245 |
| R-HSA-1640170 | Cell Cycle | 0.568494 | 0.245 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.569354 | 0.245 |
| R-HSA-109582 | Hemostasis | 0.573093 | 0.242 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.574268 | 0.241 |
| R-HSA-1221632 | Meiotic synapsis | 0.574268 | 0.241 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.574268 | 0.241 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.577886 | 0.238 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.583152 | 0.234 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.583152 | 0.234 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.583152 | 0.234 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.586045 | 0.232 |
| R-HSA-69481 | G2/M Checkpoints | 0.590863 | 0.229 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.591811 | 0.228 |
| R-HSA-75893 | TNF signaling | 0.591811 | 0.228 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.597497 | 0.224 |
| R-HSA-112399 | IRS-mediated signalling | 0.597497 | 0.224 |
| R-HSA-446728 | Cell junction organization | 0.599898 | 0.222 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.608635 | 0.216 |
| R-HSA-180786 | Extension of Telomeres | 0.608635 | 0.216 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.614088 | 0.212 |
| R-HSA-379724 | tRNA Aminoacylation | 0.614088 | 0.212 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.619465 | 0.208 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.619465 | 0.208 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.624768 | 0.204 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.624768 | 0.204 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.624768 | 0.204 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.624768 | 0.204 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.629997 | 0.201 |
| R-HSA-373755 | Semaphorin interactions | 0.629997 | 0.201 |
| R-HSA-163685 | Integration of energy metabolism | 0.631379 | 0.200 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.631379 | 0.200 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.635154 | 0.197 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.640239 | 0.194 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.641873 | 0.193 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.645254 | 0.190 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.645254 | 0.190 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.645319 | 0.190 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.645319 | 0.190 |
| R-HSA-9664407 | Parasite infection | 0.645319 | 0.190 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.648739 | 0.188 |
| R-HSA-1632852 | Macroautophagy | 0.648739 | 0.188 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.650198 | 0.187 |
| R-HSA-196807 | Nicotinate metabolism | 0.650198 | 0.187 |
| R-HSA-167172 | Transcription of the HIV genome | 0.655075 | 0.184 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.655075 | 0.184 |
| R-HSA-5218859 | Regulated Necrosis | 0.655075 | 0.184 |
| R-HSA-1643685 | Disease | 0.655150 | 0.184 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.655500 | 0.183 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.662158 | 0.179 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.664625 | 0.177 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.664625 | 0.177 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.669301 | 0.174 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.669301 | 0.174 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.669301 | 0.174 |
| R-HSA-189445 | Metabolism of porphyrins | 0.669301 | 0.174 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.673913 | 0.171 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.673913 | 0.171 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.673913 | 0.171 |
| R-HSA-69242 | S Phase | 0.675163 | 0.171 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.675163 | 0.171 |
| R-HSA-9758941 | Gastrulation | 0.678351 | 0.169 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.678460 | 0.168 |
| R-HSA-372790 | Signaling by GPCR | 0.686600 | 0.163 |
| R-HSA-8852135 | Protein ubiquitination | 0.687366 | 0.163 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.687366 | 0.163 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.687366 | 0.163 |
| R-HSA-5689603 | UCH proteinases | 0.691726 | 0.160 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.697921 | 0.156 |
| R-HSA-9612973 | Autophagy | 0.699956 | 0.155 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.700266 | 0.155 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.701103 | 0.154 |
| R-HSA-162587 | HIV Life Cycle | 0.702943 | 0.153 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.704447 | 0.152 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.708570 | 0.150 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.711756 | 0.148 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.711756 | 0.148 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.712636 | 0.147 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.724498 | 0.140 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.728343 | 0.138 |
| R-HSA-1500620 | Meiosis | 0.728343 | 0.138 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.735873 | 0.133 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.742220 | 0.129 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.750038 | 0.125 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.750038 | 0.125 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.750038 | 0.125 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.755136 | 0.122 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.760627 | 0.119 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.760627 | 0.119 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.767266 | 0.115 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.770516 | 0.113 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.776882 | 0.110 |
| R-HSA-1296071 | Potassium Channels | 0.776882 | 0.110 |
| R-HSA-157579 | Telomere Maintenance | 0.779998 | 0.108 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.783071 | 0.106 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.786140 | 0.105 |
| R-HSA-983712 | Ion channel transport | 0.788377 | 0.103 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.789533 | 0.103 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.792037 | 0.101 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.792788 | 0.101 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.799254 | 0.097 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.803419 | 0.095 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.803419 | 0.095 |
| R-HSA-9833110 | RSV-host interactions | 0.803419 | 0.095 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.803465 | 0.095 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.808876 | 0.092 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.811286 | 0.091 |
| R-HSA-69239 | Synthesis of DNA | 0.811547 | 0.091 |
| R-HSA-211000 | Gene Silencing by RNA | 0.811547 | 0.091 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.816779 | 0.088 |
| R-HSA-913531 | Interferon Signaling | 0.817737 | 0.087 |
| R-HSA-72172 | mRNA Splicing | 0.821461 | 0.085 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.829235 | 0.081 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.831623 | 0.080 |
| R-HSA-373760 | L1CAM interactions | 0.838589 | 0.076 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.840847 | 0.075 |
| R-HSA-5693538 | Homology Directed Repair | 0.843074 | 0.074 |
| R-HSA-418990 | Adherens junctions interactions | 0.846538 | 0.072 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.849568 | 0.071 |
| R-HSA-73886 | Chromosome Maintenance | 0.849568 | 0.071 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.849568 | 0.071 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.859605 | 0.066 |
| R-HSA-162906 | HIV Infection | 0.860930 | 0.065 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.861766 | 0.065 |
| R-HSA-114608 | Platelet degranulation | 0.863701 | 0.064 |
| R-HSA-72312 | rRNA processing | 0.868384 | 0.061 |
| R-HSA-1474165 | Reproduction | 0.871175 | 0.060 |
| R-HSA-9843745 | Adipogenesis | 0.872978 | 0.059 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.876511 | 0.057 |
| R-HSA-157118 | Signaling by NOTCH | 0.879553 | 0.056 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.884920 | 0.053 |
| R-HSA-6807070 | PTEN Regulation | 0.888122 | 0.052 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.890660 | 0.050 |
| R-HSA-421270 | Cell-cell junction organization | 0.893491 | 0.049 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.894262 | 0.049 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.895670 | 0.048 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.895744 | 0.048 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.899319 | 0.046 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.901467 | 0.045 |
| R-HSA-2187338 | Visual phototransduction | 0.901467 | 0.045 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.901567 | 0.045 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.906878 | 0.042 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.908183 | 0.042 |
| R-HSA-69306 | DNA Replication | 0.909471 | 0.041 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.909471 | 0.041 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.914444 | 0.039 |
| R-HSA-9711097 | Cellular response to starvation | 0.915644 | 0.038 |
| R-HSA-2262752 | Cellular responses to stress | 0.919967 | 0.036 |
| R-HSA-72306 | tRNA processing | 0.929802 | 0.032 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.931759 | 0.031 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.934594 | 0.029 |
| R-HSA-2559583 | Cellular Senescence | 0.939060 | 0.027 |
| R-HSA-418594 | G alpha (i) signalling events | 0.939537 | 0.027 |
| R-HSA-3781865 | Diseases of glycosylation | 0.942413 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.948246 | 0.023 |
| R-HSA-68877 | Mitotic Prometaphase | 0.949301 | 0.023 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.954086 | 0.020 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.955369 | 0.020 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.955997 | 0.020 |
| R-HSA-8953854 | Metabolism of RNA | 0.957266 | 0.019 |
| R-HSA-199991 | Membrane Trafficking | 0.958761 | 0.018 |
| R-HSA-9679506 | SARS-CoV Infections | 0.961476 | 0.017 |
| R-HSA-397014 | Muscle contraction | 0.961811 | 0.017 |
| R-HSA-68882 | Mitotic Anaphase | 0.963917 | 0.016 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.964425 | 0.016 |
| R-HSA-9748784 | Drug ADME | 0.964926 | 0.016 |
| R-HSA-8951664 | Neddylation | 0.966387 | 0.015 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.969565 | 0.013 |
| R-HSA-73894 | DNA Repair | 0.970134 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.970416 | 0.013 |
| R-HSA-68886 | M Phase | 0.977388 | 0.010 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.982760 | 0.008 |
| R-HSA-168249 | Innate Immune System | 0.983975 | 0.007 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.985875 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 0.986986 | 0.006 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.991177 | 0.004 |
| R-HSA-112316 | Neuronal System | 0.992197 | 0.003 |
| R-HSA-8957322 | Metabolism of steroids | 0.992239 | 0.003 |
| R-HSA-1280218 | Adaptive Immune System | 0.993357 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.994933 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.995619 | 0.002 |
| R-HSA-168256 | Immune System | 0.996414 | 0.002 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.996710 | 0.001 |
| R-HSA-9824446 | Viral Infection Pathways | 0.996956 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.997024 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998277 | 0.001 |
| R-HSA-72766 | Translation | 0.998300 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998339 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998581 | 0.001 |
| R-HSA-6798695 | Neutrophil degranulation | 0.998864 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999316 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999792 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.853 | 0.818 | 1 | 0.880 |
HIPK2 |
0.852 | 0.763 | 1 | 0.870 |
KIS |
0.851 | 0.730 | 1 | 0.835 |
CDK19 |
0.850 | 0.790 | 1 | 0.872 |
CDK3 |
0.849 | 0.731 | 1 | 0.897 |
P38G |
0.849 | 0.841 | 1 | 0.906 |
CDK17 |
0.848 | 0.824 | 1 | 0.901 |
CDK1 |
0.847 | 0.797 | 1 | 0.864 |
JNK2 |
0.846 | 0.846 | 1 | 0.884 |
CDK8 |
0.845 | 0.787 | 1 | 0.846 |
CDK13 |
0.843 | 0.813 | 1 | 0.869 |
P38D |
0.843 | 0.823 | 1 | 0.913 |
CDK5 |
0.841 | 0.789 | 1 | 0.825 |
CDK7 |
0.840 | 0.782 | 1 | 0.851 |
CDK12 |
0.839 | 0.808 | 1 | 0.884 |
CDK16 |
0.838 | 0.783 | 1 | 0.893 |
DYRK2 |
0.838 | 0.736 | 1 | 0.804 |
JNK3 |
0.837 | 0.830 | 1 | 0.865 |
ERK1 |
0.837 | 0.792 | 1 | 0.860 |
CLK3 |
0.836 | 0.534 | 1 | 0.594 |
P38B |
0.836 | 0.799 | 1 | 0.847 |
HIPK4 |
0.832 | 0.530 | 1 | 0.613 |
DYRK4 |
0.832 | 0.734 | 1 | 0.883 |
CDK9 |
0.831 | 0.781 | 1 | 0.864 |
SRPK1 |
0.830 | 0.412 | -3 | 0.756 |
CDK10 |
0.829 | 0.747 | 1 | 0.865 |
HIPK1 |
0.829 | 0.690 | 1 | 0.789 |
CDK14 |
0.828 | 0.777 | 1 | 0.853 |
P38A |
0.823 | 0.765 | 1 | 0.790 |
DYRK1B |
0.822 | 0.704 | 1 | 0.842 |
CDK6 |
0.821 | 0.769 | 1 | 0.868 |
CDK4 |
0.820 | 0.786 | 1 | 0.892 |
CLK2 |
0.820 | 0.448 | -3 | 0.766 |
JNK1 |
0.818 | 0.741 | 1 | 0.884 |
SRPK2 |
0.818 | 0.338 | -3 | 0.688 |
NLK |
0.818 | 0.699 | 1 | 0.624 |
DYRK1A |
0.815 | 0.600 | 1 | 0.773 |
ERK2 |
0.814 | 0.762 | 1 | 0.820 |
HIPK3 |
0.814 | 0.659 | 1 | 0.761 |
ERK5 |
0.809 | 0.402 | 1 | 0.521 |
CDK2 |
0.808 | 0.584 | 1 | 0.762 |
CLK1 |
0.808 | 0.424 | -3 | 0.758 |
MAK |
0.806 | 0.521 | -2 | 0.757 |
DYRK3 |
0.804 | 0.528 | 1 | 0.757 |
SRPK3 |
0.803 | 0.307 | -3 | 0.722 |
CLK4 |
0.803 | 0.381 | -3 | 0.770 |
MTOR |
0.803 | 0.236 | 1 | 0.421 |
COT |
0.802 | -0.000 | 2 | 0.821 |
ICK |
0.801 | 0.379 | -3 | 0.830 |
CDKL5 |
0.797 | 0.190 | -3 | 0.793 |
NDR2 |
0.795 | 0.068 | -3 | 0.850 |
CDKL1 |
0.793 | 0.168 | -3 | 0.797 |
PRKD1 |
0.792 | 0.077 | -3 | 0.828 |
PIM3 |
0.791 | 0.039 | -3 | 0.840 |
PRP4 |
0.791 | 0.439 | -3 | 0.691 |
MOK |
0.791 | 0.472 | 1 | 0.674 |
CDC7 |
0.789 | -0.063 | 1 | 0.280 |
MOS |
0.787 | 0.000 | 1 | 0.323 |
PRKD2 |
0.785 | 0.051 | -3 | 0.796 |
PRPK |
0.784 | -0.064 | -1 | 0.808 |
TBK1 |
0.784 | -0.126 | 1 | 0.231 |
ATR |
0.783 | -0.024 | 1 | 0.301 |
CHAK2 |
0.783 | 0.005 | -1 | 0.789 |
RSK2 |
0.783 | 0.040 | -3 | 0.787 |
PIM1 |
0.782 | 0.064 | -3 | 0.790 |
NEK6 |
0.782 | -0.016 | -2 | 0.891 |
IKKB |
0.782 | -0.129 | -2 | 0.793 |
NDR1 |
0.782 | -0.004 | -3 | 0.838 |
ERK7 |
0.781 | 0.273 | 2 | 0.534 |
P90RSK |
0.781 | 0.045 | -3 | 0.783 |
IKKE |
0.781 | -0.131 | 1 | 0.230 |
PKN3 |
0.781 | -0.005 | -3 | 0.825 |
LATS2 |
0.780 | 0.016 | -5 | 0.744 |
GCN2 |
0.780 | -0.162 | 2 | 0.750 |
NUAK2 |
0.780 | 0.038 | -3 | 0.843 |
PDHK4 |
0.779 | -0.152 | 1 | 0.324 |
DSTYK |
0.779 | -0.111 | 2 | 0.834 |
CAMK1B |
0.779 | -0.021 | -3 | 0.843 |
PKCD |
0.778 | 0.019 | 2 | 0.728 |
MAPKAPK2 |
0.778 | 0.021 | -3 | 0.760 |
MST4 |
0.778 | -0.025 | 2 | 0.808 |
ULK2 |
0.778 | -0.145 | 2 | 0.728 |
RAF1 |
0.778 | -0.186 | 1 | 0.266 |
PDHK1 |
0.778 | -0.127 | 1 | 0.309 |
SKMLCK |
0.777 | -0.011 | -2 | 0.870 |
MARK4 |
0.777 | -0.020 | 4 | 0.792 |
IKKA |
0.776 | -0.039 | -2 | 0.782 |
BMPR2 |
0.776 | -0.132 | -2 | 0.916 |
GRK1 |
0.776 | 0.001 | -2 | 0.800 |
NIK |
0.776 | -0.021 | -3 | 0.853 |
CAMK2D |
0.776 | -0.032 | -3 | 0.825 |
WNK1 |
0.775 | -0.055 | -2 | 0.911 |
AMPKA1 |
0.775 | -0.014 | -3 | 0.850 |
RSK3 |
0.775 | 0.006 | -3 | 0.780 |
AURC |
0.775 | 0.031 | -2 | 0.632 |
MAPKAPK3 |
0.774 | -0.015 | -3 | 0.791 |
TGFBR2 |
0.773 | -0.052 | -2 | 0.821 |
AMPKA2 |
0.773 | 0.005 | -3 | 0.831 |
LATS1 |
0.772 | 0.072 | -3 | 0.864 |
PKN2 |
0.772 | -0.038 | -3 | 0.827 |
CAMK2G |
0.772 | -0.112 | 2 | 0.748 |
TSSK1 |
0.771 | 0.001 | -3 | 0.870 |
BCKDK |
0.771 | -0.123 | -1 | 0.762 |
CAMLCK |
0.771 | -0.019 | -2 | 0.860 |
MLK2 |
0.770 | -0.054 | 2 | 0.779 |
NEK7 |
0.770 | -0.147 | -3 | 0.799 |
GRK5 |
0.770 | -0.127 | -3 | 0.794 |
GRK7 |
0.770 | 0.023 | 1 | 0.279 |
PAK6 |
0.769 | 0.043 | -2 | 0.711 |
PKCA |
0.769 | 0.024 | 2 | 0.674 |
MPSK1 |
0.769 | 0.128 | 1 | 0.308 |
P70S6KB |
0.769 | -0.005 | -3 | 0.799 |
DAPK2 |
0.768 | -0.035 | -3 | 0.846 |
GSK3A |
0.768 | 0.203 | 4 | 0.463 |
PKCB |
0.768 | 0.003 | 2 | 0.688 |
QSK |
0.768 | 0.008 | 4 | 0.769 |
NEK9 |
0.768 | -0.120 | 2 | 0.794 |
RSK4 |
0.767 | 0.033 | -3 | 0.771 |
DNAPK |
0.767 | -0.024 | 1 | 0.276 |
MLK3 |
0.767 | -0.038 | 2 | 0.692 |
MNK2 |
0.767 | -0.012 | -2 | 0.791 |
PKACB |
0.767 | 0.035 | -2 | 0.649 |
CAMK2A |
0.767 | 0.008 | 2 | 0.735 |
HUNK |
0.767 | -0.136 | 2 | 0.758 |
PKACG |
0.767 | -0.028 | -2 | 0.728 |
ULK1 |
0.766 | -0.157 | -3 | 0.769 |
IRE1 |
0.766 | -0.065 | 1 | 0.246 |
PHKG1 |
0.766 | -0.029 | -3 | 0.819 |
MLK1 |
0.766 | -0.153 | 2 | 0.758 |
CAMK2B |
0.766 | -0.028 | 2 | 0.727 |
PINK1 |
0.766 | 0.183 | 1 | 0.452 |
NIM1 |
0.766 | -0.060 | 3 | 0.716 |
BMPR1B |
0.766 | -0.023 | 1 | 0.239 |
MNK1 |
0.765 | 0.009 | -2 | 0.796 |
PRKD3 |
0.765 | 0.012 | -3 | 0.757 |
MASTL |
0.765 | -0.137 | -2 | 0.859 |
RIPK3 |
0.764 | -0.171 | 3 | 0.696 |
TSSK2 |
0.764 | -0.057 | -5 | 0.836 |
PKCG |
0.763 | -0.018 | 2 | 0.681 |
NUAK1 |
0.763 | -0.015 | -3 | 0.804 |
AKT2 |
0.763 | 0.048 | -3 | 0.709 |
VRK2 |
0.763 | 0.107 | 1 | 0.363 |
PKCZ |
0.763 | -0.015 | 2 | 0.735 |
PRKX |
0.762 | 0.045 | -3 | 0.721 |
MELK |
0.762 | -0.042 | -3 | 0.811 |
SIK |
0.762 | -0.012 | -3 | 0.767 |
ATM |
0.762 | -0.089 | 1 | 0.269 |
ALK4 |
0.762 | -0.038 | -2 | 0.875 |
TGFBR1 |
0.761 | -0.030 | -2 | 0.846 |
PKR |
0.761 | -0.059 | 1 | 0.279 |
PAK1 |
0.761 | -0.048 | -2 | 0.780 |
IRE2 |
0.761 | -0.051 | 2 | 0.684 |
SGK3 |
0.761 | 0.011 | -3 | 0.778 |
PIM2 |
0.760 | 0.045 | -3 | 0.759 |
CHAK1 |
0.760 | -0.094 | 2 | 0.747 |
DLK |
0.759 | -0.199 | 1 | 0.266 |
SMG1 |
0.759 | -0.067 | 1 | 0.280 |
PAK3 |
0.759 | -0.074 | -2 | 0.784 |
GRK6 |
0.759 | -0.154 | 1 | 0.264 |
FAM20C |
0.758 | -0.030 | 2 | 0.563 |
DCAMKL1 |
0.758 | 0.004 | -3 | 0.804 |
WNK3 |
0.758 | -0.232 | 1 | 0.255 |
YSK4 |
0.758 | -0.129 | 1 | 0.236 |
PKG2 |
0.758 | -0.002 | -2 | 0.652 |
CHK1 |
0.757 | -0.015 | -3 | 0.848 |
MSK2 |
0.757 | -0.038 | -3 | 0.742 |
BRSK1 |
0.757 | -0.041 | -3 | 0.798 |
QIK |
0.757 | -0.083 | -3 | 0.816 |
MARK3 |
0.757 | -0.022 | 4 | 0.725 |
NEK2 |
0.757 | -0.104 | 2 | 0.774 |
BRSK2 |
0.757 | -0.060 | -3 | 0.809 |
ANKRD3 |
0.756 | -0.190 | 1 | 0.274 |
RIPK1 |
0.756 | -0.205 | 1 | 0.243 |
TTBK2 |
0.756 | -0.181 | 2 | 0.676 |
TLK2 |
0.755 | -0.093 | 1 | 0.239 |
PKCH |
0.754 | -0.052 | 2 | 0.663 |
MSK1 |
0.754 | -0.019 | -3 | 0.756 |
CAMK4 |
0.754 | -0.123 | -3 | 0.814 |
GRK4 |
0.754 | -0.176 | -2 | 0.838 |
MLK4 |
0.753 | -0.101 | 2 | 0.674 |
AURB |
0.753 | -0.028 | -2 | 0.631 |
AKT1 |
0.752 | 0.021 | -3 | 0.732 |
MARK2 |
0.752 | -0.044 | 4 | 0.693 |
TAO3 |
0.751 | -0.006 | 1 | 0.279 |
MEKK1 |
0.751 | -0.098 | 1 | 0.267 |
MEK1 |
0.750 | -0.162 | 2 | 0.777 |
ALK2 |
0.750 | -0.068 | -2 | 0.851 |
ACVR2B |
0.750 | -0.095 | -2 | 0.831 |
MST3 |
0.749 | -0.038 | 2 | 0.792 |
GSK3B |
0.749 | 0.051 | 4 | 0.456 |
ACVR2A |
0.749 | -0.098 | -2 | 0.821 |
PKCT |
0.748 | -0.038 | 2 | 0.675 |
NEK5 |
0.748 | -0.085 | 1 | 0.247 |
MAPKAPK5 |
0.748 | -0.081 | -3 | 0.717 |
BRAF |
0.748 | -0.107 | -4 | 0.801 |
PERK |
0.748 | -0.122 | -2 | 0.874 |
PLK1 |
0.748 | -0.167 | -2 | 0.819 |
ZAK |
0.747 | -0.132 | 1 | 0.247 |
PAK5 |
0.747 | -0.015 | -2 | 0.637 |
PAK2 |
0.747 | -0.100 | -2 | 0.768 |
BUB1 |
0.747 | 0.076 | -5 | 0.797 |
PKACA |
0.747 | 0.006 | -2 | 0.596 |
PHKG2 |
0.746 | -0.059 | -3 | 0.799 |
PLK4 |
0.746 | -0.126 | 2 | 0.564 |
LKB1 |
0.746 | 0.012 | -3 | 0.786 |
MEKK2 |
0.745 | -0.107 | 2 | 0.753 |
PASK |
0.745 | -0.014 | -3 | 0.849 |
IRAK4 |
0.745 | -0.108 | 1 | 0.236 |
DCAMKL2 |
0.745 | -0.040 | -3 | 0.819 |
PAK4 |
0.745 | -0.001 | -2 | 0.636 |
WNK4 |
0.745 | -0.115 | -2 | 0.919 |
MEK5 |
0.744 | -0.156 | 2 | 0.763 |
MARK1 |
0.744 | -0.076 | 4 | 0.740 |
TNIK |
0.744 | 0.026 | 3 | 0.863 |
CAMK1G |
0.744 | -0.061 | -3 | 0.762 |
SSTK |
0.743 | -0.049 | 4 | 0.760 |
BMPR1A |
0.743 | -0.058 | 1 | 0.235 |
HRI |
0.743 | -0.156 | -2 | 0.883 |
PDK1 |
0.743 | -0.028 | 1 | 0.291 |
HGK |
0.743 | -0.003 | 3 | 0.860 |
PLK3 |
0.743 | -0.143 | 2 | 0.693 |
PKCI |
0.743 | -0.028 | 2 | 0.697 |
AKT3 |
0.742 | 0.034 | -3 | 0.657 |
MYLK4 |
0.742 | -0.073 | -2 | 0.764 |
PKCE |
0.742 | 0.004 | 2 | 0.669 |
SBK |
0.742 | 0.125 | -3 | 0.610 |
P70S6K |
0.741 | -0.034 | -3 | 0.719 |
GCK |
0.741 | -0.028 | 1 | 0.254 |
KHS1 |
0.741 | 0.033 | 1 | 0.253 |
AURA |
0.741 | -0.054 | -2 | 0.595 |
TAO2 |
0.741 | -0.033 | 2 | 0.792 |
DRAK1 |
0.740 | -0.166 | 1 | 0.206 |
GRK2 |
0.739 | -0.109 | -2 | 0.725 |
SNRK |
0.739 | -0.177 | 2 | 0.601 |
PKN1 |
0.739 | -0.017 | -3 | 0.734 |
KHS2 |
0.739 | 0.041 | 1 | 0.261 |
SGK1 |
0.738 | 0.042 | -3 | 0.641 |
EEF2K |
0.738 | -0.018 | 3 | 0.837 |
GAK |
0.737 | -0.045 | 1 | 0.307 |
PBK |
0.737 | 0.001 | 1 | 0.276 |
MAP3K15 |
0.737 | -0.060 | 1 | 0.254 |
CAMK1D |
0.736 | -0.030 | -3 | 0.706 |
MEKK3 |
0.736 | -0.217 | 1 | 0.253 |
LOK |
0.735 | -0.040 | -2 | 0.792 |
SMMLCK |
0.735 | -0.064 | -3 | 0.806 |
MINK |
0.735 | -0.069 | 1 | 0.235 |
NEK8 |
0.735 | -0.149 | 2 | 0.758 |
LRRK2 |
0.735 | 0.004 | 2 | 0.789 |
TLK1 |
0.735 | -0.169 | -2 | 0.847 |
CK1E |
0.735 | -0.069 | -3 | 0.461 |
CAMKK2 |
0.735 | -0.105 | -2 | 0.812 |
CAMKK1 |
0.735 | -0.147 | -2 | 0.815 |
NEK4 |
0.734 | -0.118 | 1 | 0.236 |
HPK1 |
0.734 | -0.046 | 1 | 0.255 |
HASPIN |
0.734 | 0.045 | -1 | 0.684 |
ROCK2 |
0.733 | 0.005 | -3 | 0.797 |
MEKK6 |
0.733 | -0.091 | 1 | 0.248 |
NEK1 |
0.732 | -0.086 | 1 | 0.233 |
CK1G1 |
0.731 | -0.090 | -3 | 0.451 |
MST2 |
0.731 | -0.122 | 1 | 0.249 |
NEK11 |
0.731 | -0.171 | 1 | 0.270 |
CHK2 |
0.731 | -0.007 | -3 | 0.661 |
MRCKB |
0.730 | -0.005 | -3 | 0.749 |
CK1D |
0.730 | -0.043 | -3 | 0.406 |
SLK |
0.730 | -0.053 | -2 | 0.735 |
DAPK3 |
0.730 | -0.047 | -3 | 0.801 |
CK2A2 |
0.730 | -0.088 | 1 | 0.205 |
YSK1 |
0.728 | -0.074 | 2 | 0.768 |
MRCKA |
0.727 | -0.021 | -3 | 0.765 |
CAMK1A |
0.727 | -0.016 | -3 | 0.683 |
VRK1 |
0.727 | -0.119 | 2 | 0.790 |
TTBK1 |
0.727 | -0.187 | 2 | 0.586 |
PDHK3_TYR |
0.726 | 0.185 | 4 | 0.841 |
GRK3 |
0.724 | -0.112 | -2 | 0.675 |
DMPK1 |
0.723 | 0.028 | -3 | 0.775 |
MST1 |
0.723 | -0.137 | 1 | 0.236 |
TAK1 |
0.722 | -0.191 | 1 | 0.243 |
NEK3 |
0.722 | -0.089 | 1 | 0.253 |
AAK1 |
0.722 | 0.039 | 1 | 0.276 |
STK33 |
0.721 | -0.124 | 2 | 0.552 |
BIKE |
0.721 | -0.013 | 1 | 0.286 |
IRAK1 |
0.720 | -0.256 | -1 | 0.692 |
CK1A2 |
0.720 | -0.079 | -3 | 0.409 |
LIMK2_TYR |
0.720 | 0.168 | -3 | 0.863 |
PLK2 |
0.719 | -0.085 | -3 | 0.746 |
CK2A1 |
0.719 | -0.099 | 1 | 0.192 |
DAPK1 |
0.719 | -0.065 | -3 | 0.778 |
OSR1 |
0.719 | -0.050 | 2 | 0.750 |
CRIK |
0.718 | 0.010 | -3 | 0.737 |
TESK1_TYR |
0.718 | 0.082 | 3 | 0.831 |
MYO3B |
0.718 | -0.028 | 2 | 0.780 |
MEK2 |
0.717 | -0.185 | 2 | 0.761 |
ROCK1 |
0.716 | -0.023 | -3 | 0.761 |
PKMYT1_TYR |
0.715 | 0.132 | 3 | 0.791 |
PDHK4_TYR |
0.715 | 0.065 | 2 | 0.802 |
TAO1 |
0.715 | -0.057 | 1 | 0.244 |
PKG1 |
0.714 | -0.045 | -2 | 0.565 |
MAP2K4_TYR |
0.714 | 0.040 | -1 | 0.830 |
ASK1 |
0.713 | -0.102 | 1 | 0.258 |
RIPK2 |
0.711 | -0.242 | 1 | 0.228 |
MAP2K6_TYR |
0.710 | 0.007 | -1 | 0.831 |
MYO3A |
0.710 | -0.072 | 1 | 0.257 |
TTK |
0.710 | -0.087 | -2 | 0.831 |
MAP2K7_TYR |
0.709 | -0.071 | 2 | 0.791 |
TNNI3K_TYR |
0.706 | 0.035 | 1 | 0.297 |
PINK1_TYR |
0.705 | -0.126 | 1 | 0.309 |
BMPR2_TYR |
0.704 | -0.041 | -1 | 0.789 |
LIMK1_TYR |
0.704 | -0.000 | 2 | 0.796 |
RET |
0.704 | -0.108 | 1 | 0.279 |
PDHK1_TYR |
0.703 | -0.087 | -1 | 0.827 |
TYK2 |
0.703 | -0.136 | 1 | 0.270 |
JAK2 |
0.702 | -0.084 | 1 | 0.289 |
NEK10_TYR |
0.701 | -0.064 | 1 | 0.239 |
MST1R |
0.701 | -0.093 | 3 | 0.757 |
CSF1R |
0.700 | -0.071 | 3 | 0.740 |
YANK3 |
0.699 | -0.076 | 2 | 0.358 |
JAK1 |
0.699 | -0.043 | 1 | 0.251 |
ROS1 |
0.698 | -0.097 | 3 | 0.715 |
ABL2 |
0.696 | -0.089 | -1 | 0.744 |
ALPHAK3 |
0.695 | -0.140 | -1 | 0.705 |
TNK1 |
0.695 | -0.034 | 3 | 0.729 |
TYRO3 |
0.695 | -0.139 | 3 | 0.750 |
FGR |
0.693 | -0.118 | 1 | 0.239 |
EPHA6 |
0.693 | -0.126 | -1 | 0.762 |
STLK3 |
0.693 | -0.176 | 1 | 0.229 |
EPHB4 |
0.693 | -0.129 | -1 | 0.750 |
ABL1 |
0.691 | -0.102 | -1 | 0.738 |
YES1 |
0.691 | -0.100 | -1 | 0.788 |
JAK3 |
0.691 | -0.137 | 1 | 0.264 |
TNK2 |
0.690 | -0.099 | 3 | 0.674 |
TXK |
0.690 | -0.086 | 1 | 0.230 |
DDR1 |
0.690 | -0.155 | 4 | 0.756 |
FGFR2 |
0.690 | -0.073 | 3 | 0.720 |
CK1A |
0.690 | -0.084 | -3 | 0.317 |
FGFR1 |
0.690 | -0.054 | 3 | 0.694 |
KDR |
0.688 | -0.093 | 3 | 0.707 |
LCK |
0.687 | -0.094 | -1 | 0.736 |
FLT3 |
0.686 | -0.169 | 3 | 0.753 |
PDGFRB |
0.686 | -0.187 | 3 | 0.751 |
HCK |
0.686 | -0.145 | -1 | 0.739 |
BLK |
0.685 | -0.081 | -1 | 0.745 |
KIT |
0.685 | -0.143 | 3 | 0.736 |
TEK |
0.684 | -0.056 | 3 | 0.657 |
PDGFRA |
0.683 | -0.187 | 3 | 0.750 |
WEE1_TYR |
0.682 | -0.072 | -1 | 0.676 |
FER |
0.682 | -0.215 | 1 | 0.265 |
INSRR |
0.682 | -0.176 | 3 | 0.674 |
EPHA4 |
0.682 | -0.129 | 2 | 0.689 |
ITK |
0.681 | -0.159 | -1 | 0.713 |
SRMS |
0.680 | -0.199 | 1 | 0.241 |
EPHB1 |
0.680 | -0.197 | 1 | 0.244 |
AXL |
0.679 | -0.174 | 3 | 0.710 |
MET |
0.679 | -0.138 | 3 | 0.720 |
MERTK |
0.678 | -0.158 | 3 | 0.712 |
EPHB3 |
0.678 | -0.183 | -1 | 0.728 |
DDR2 |
0.678 | -0.051 | 3 | 0.648 |
FGFR3 |
0.677 | -0.100 | 3 | 0.692 |
EPHB2 |
0.676 | -0.181 | -1 | 0.722 |
BMX |
0.676 | -0.130 | -1 | 0.628 |
FYN |
0.675 | -0.107 | -1 | 0.718 |
ALK |
0.675 | -0.172 | 3 | 0.636 |
FRK |
0.674 | -0.155 | -1 | 0.746 |
PTK6 |
0.674 | -0.198 | -1 | 0.666 |
BTK |
0.673 | -0.218 | -1 | 0.688 |
FLT1 |
0.673 | -0.165 | -1 | 0.753 |
TEC |
0.673 | -0.166 | -1 | 0.660 |
NTRK1 |
0.673 | -0.219 | -1 | 0.766 |
LTK |
0.673 | -0.186 | 3 | 0.664 |
ERBB2 |
0.672 | -0.186 | 1 | 0.250 |
NTRK3 |
0.672 | -0.151 | -1 | 0.719 |
EGFR |
0.672 | -0.117 | 1 | 0.216 |
FLT4 |
0.671 | -0.179 | 3 | 0.692 |
EPHA7 |
0.671 | -0.160 | 2 | 0.690 |
EPHA1 |
0.670 | -0.175 | 3 | 0.710 |
NTRK2 |
0.670 | -0.220 | 3 | 0.685 |
INSR |
0.668 | -0.183 | 3 | 0.658 |
LYN |
0.668 | -0.159 | 3 | 0.660 |
CK1G3 |
0.668 | -0.094 | -3 | 0.273 |
EPHA3 |
0.667 | -0.183 | 2 | 0.665 |
MATK |
0.667 | -0.124 | -1 | 0.676 |
SRC |
0.666 | -0.138 | -1 | 0.727 |
PTK2B |
0.666 | -0.145 | -1 | 0.702 |
MUSK |
0.666 | -0.132 | 1 | 0.195 |
FGFR4 |
0.665 | -0.129 | -1 | 0.698 |
YANK2 |
0.662 | -0.103 | 2 | 0.369 |
EPHA8 |
0.662 | -0.158 | -1 | 0.699 |
EPHA5 |
0.661 | -0.178 | 2 | 0.667 |
CSK |
0.661 | -0.178 | 2 | 0.698 |
SYK |
0.658 | -0.124 | -1 | 0.676 |
PTK2 |
0.657 | -0.111 | -1 | 0.685 |
ERBB4 |
0.654 | -0.124 | 1 | 0.220 |
EPHA2 |
0.652 | -0.166 | -1 | 0.665 |
IGF1R |
0.649 | -0.188 | 3 | 0.584 |
ZAP70 |
0.648 | -0.080 | -1 | 0.603 |
CK1G2 |
0.642 | -0.106 | -3 | 0.367 |
FES |
0.633 | -0.194 | -1 | 0.613 |