Motif 152 (n=180)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0J9YVX5 None S39 ochoa Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) None
A1A4S6 ARHGAP10 S374 ochoa Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}.
A5PLL1 ANKRD34B S407 ochoa Ankyrin repeat domain-containing protein 34B None
A8MYZ6 FOXO6 S214 ochoa Forkhead box protein O6 Transcriptional activator. {ECO:0000250}.
H7BY64 ZNF511-PRAP1 S138 ochoa ZNF511-PRAP1 readthrough None
O00161 SNAP23 S110 ochoa|psp Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
O00512 BCL9 S157 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O14654 IRS4 Y743 ochoa Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.
O14681 EI24 S320 ochoa Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.
O14893 GEMIN2 S87 ochoa Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}.
O14983 ATP2A1 S186 ochoa|psp Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}.
O15047 SETD1A S534 ochoa Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}.
O15055 PER2 S696 psp Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}.
O15117 FYB1 S386 ochoa FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
O15389 SIGLEC5 S488 ochoa Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
O43683 BUB1 S437 ochoa Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O60237 PPP1R12B S395 ochoa Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
O60237 PPP1R12B S790 ochoa Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
O60238 BNIP3L S87 ochoa BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
O60308 CEP104 S357 ochoa Centrosomal protein of 104 kDa (Cep104) Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}.
O75362 ZNF217 S411 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O75376 NCOR1 S1958 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75391 SPAG7 S63 ochoa Sperm-associated antigen 7 None
O75449 KATNA1 S80 ochoa Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.
O75665 OFD1 S660 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O75674 TOM1L1 S311 ochoa TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.
O75962 TRIO S1814 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
O94929 ABLIM3 S483 ochoa Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
O95149 SNUPN S340 ochoa Snurportin-1 (RNA U transporter 1) Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}.
O95716 RAB3D S199 ochoa Ras-related protein Rab-3D (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (By similarity). {ECO:0000250|UniProtKB:P20336, ECO:0000250|UniProtKB:P35276}.
P08172 CHRM2 S232 ochoa|psp Muscarinic acetylcholine receptor M2 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.
P09211 GSTP1 S43 psp Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}.
P09429 HMGB1 S100 ochoa High mobility group protein B1 (High mobility group protein 1) (HMG-1) Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}.
P09874 PARP1 S362 ochoa Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.
P10636 MAPT S228 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11388 TOP2A S1303 ochoa DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
P12270 TPR S1662 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P16615 ATP2A2 S186 ochoa Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.
P25054 APC S1906 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P25054 APC S2205 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P27694 RPA1 S392 ochoa Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}.
P29350 PTPN6 S534 ochoa Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}.
P29372 MPG S34 ochoa DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
P29401 TKT S295 ochoa Transketolase (TK) (EC 2.2.1.1) Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.
P38398 BRCA1 S1009 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P40189 IL6ST S661 ochoa Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:19915009, PubMed:2261637, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}.
P40926 MDH2 S310 ochoa Malate dehydrogenase, mitochondrial (EC 1.1.1.37) None
P41162 ETV3 S133 ochoa ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.
P45985 MAP2K4 S257 ochoa|psp Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.
P46087 NOP2 S599 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P46734 MAP2K3 S218 ochoa|psp Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.
P48729 CSNK1A1 S242 psp Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}.
P49792 RANBP2 S1456 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2805 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49918 CDKN1C S287 ochoa Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
P51825 AFF1 S620 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P52564 MAP2K6 S207 ochoa|psp Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}.
P52735 VAV2 S576 ochoa Guanine nucleotide exchange factor VAV2 (VAV-2) Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.
P53004 BLVRA S21 psp Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}.
P55265 ADAR S593 ochoa Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}.
P56945 BCAR1 S438 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P62906 RPL10A S115 ochoa Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
P78368 CSNK1G2 S33 ochoa Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}.
P80723 BASP1 S176 ochoa Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) None
Q02880 TOP2B S1340 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q02952 AKAP12 S504 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q02952 AKAP12 S544 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164 KMT2A S187 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q08050 FOXM1 S567 psp Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q12789 GTF3C1 S846 ochoa General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Q12802 AKAP13 S943 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12830 BPTF S1373 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12830 BPTF S1374 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12923 PTPN13 S969 ochoa Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Q13029 PRDM2 S787 ochoa PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}.
Q13233 MAP3K1 S232 ochoa Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.
Q13416 ORC2 S139 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q13428 TCOF1 S583 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13625 TP53BP2 S683 ochoa Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13671 RIN1 S255 ochoa Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}.
Q13905 RAPGEF1 S562 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q14244 MAP7 S308 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14684 RRP1B S453 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14938 NFIX S341 ochoa Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q14966 ZNF638 S383 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q14CZ8 HEPACAM S318 ochoa Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205). {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256, ECO:0000269|PubMed:22405205}.
Q15468 STIL S395 ochoa|psp SCL-interrupting locus protein (TAL-1-interrupting locus protein) Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}.
Q15811 ITSN1 S976 ochoa Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}.
Q16666 IFI16 S113 ochoa Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}.
Q16821 PPP1R3A S266 ochoa Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}.
Q2TV78 MST1L S398 ochoa Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog) None
Q52LW3 ARHGAP29 S983 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q5M775 SPECC1 S315 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5SY16 NOL9 S241 ochoa Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}.
Q5T1M5 FKBP15 S303 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5T5Y3 CAMSAP1 S1126 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5VT52 RPRD2 S899 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5VWG9 TAF3 S236 ochoa Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}.
Q641Q2 WASHC2A S939 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q641Q2 WASHC2A S1179 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6DN14 MCTP1 S95 ochoa Multiple C2 and transmembrane domain-containing protein 1 Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.
Q6IAA8 LAMTOR1 S98 ochoa Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.
Q6PD62 CTR9 S970 ochoa RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.
Q6UX68 XKR5 Y369 psp XK-related protein 5 None
Q6ZNL6 FGD5 S744 ochoa FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Q7KZI7 MARK2 S448 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7Z2T5 TRMT1L S243 ochoa tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}.
Q7Z417 NUFIP2 S333 ochoa FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
Q7Z4V5 HDGFL2 S236 ochoa Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}.
Q7Z5J4 RAI1 S846 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z6B7 SRGAP1 S941 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q86SJ2 AMIGO2 S438 ochoa Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Q86X51 EZHIP S222 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q86YS7 C2CD5 S637 ochoa C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}.
Q8IUD2 ERC1 S995 ochoa ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.
Q8IWC1 MAP7D3 S490 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8IWC1 MAP7D3 S499 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8IYB3 SRRM1 S748 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8NB15 ZNF511 S195 ochoa Zinc finger protein 511 May be involved in transcriptional regulation. {ECO:0000305}.
Q8WWI1 LMO7 S1204 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WWQ0 PHIP S1456 ochoa PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}.
Q92738 USP6NL S546 ochoa USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.
Q96CF2 CHMP4C S192 ochoa Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}.
Q96E39 RBMXL1 S189 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96JM3 CHAMP1 S483 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96JM7 L3MBTL3 S670 ochoa Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96JT2 SLC45A3 S426 ochoa Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}.
Q96T25 ZIC5 S566 ochoa Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5) Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity). {ECO:0000250}.
Q99550 MPHOSPH9 S984 ochoa M-phase phosphoprotein 9 Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}.
Q99569 PKP4 S1016 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q9BRG2 SH2D3A S225 ochoa SH2 domain-containing protein 3A (Novel SH2-containing protein 1) May play a role in JNK activation.
Q9BRQ0 PYGO2 S56 ochoa Pygopus homolog 2 Involved in signal transduction through the Wnt pathway.
Q9BRR8 GPATCH1 S357 ochoa G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) None
Q9BTC0 DIDO1 S885 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BTV7 CABLES2 S257 ochoa CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) Unknown. Probably involved in G1-S cell cycle transition.
Q9BV36 MLPH S569 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BV73 CEP250 S2322 ochoa Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}.
Q9BX66 SORBS1 S76 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXW9 FANCD2 S886 ochoa|psp Fanconi anemia group D2 protein (Protein FACD2) Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}.
Q9BYW2 SETD2 S1849 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BZ67 FRMD8 S446 ochoa FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.
Q9BZQ8 NIBAN1 S577 ochoa Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9C026 TRIM9 S80 psp E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}.
Q9C0D5 TANC1 S300 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9GZV9 FGF23 S207 psp Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
Q9H6R7 WDCP S510 ochoa WD repeat and coiled-coil-containing protein None
Q9HB58 SP110 S248 ochoa Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HBM6 TAF9B S147 ochoa Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.
Q9HCM7 FBRSL1 S131 ochoa Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) None
Q9HD26 GOPC S276 ochoa Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}.
Q9HDC5 JPH1 S530 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NR48 ASH1L S1943 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NVI1 FANCI S1120 ochoa Fanconi anemia group I protein (Protein FACI) Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}.
Q9NVZ3 NECAP2 S181 ochoa Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) Involved in endocytosis. {ECO:0000250}.
Q9NZJ0 DTL S425 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9P0K7 RAI14 S239 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P0K8 FOXJ2 S39 ochoa Forkhead box protein J2 (Fork head homologous X) [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}.
Q9P246 STIM2 S599 ochoa Stromal interaction molecule 2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Q9P260 RELCH S341 ochoa RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}.
Q9P270 SLAIN2 S35 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UBW7 ZMYM2 S1060 ochoa Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}.
Q9UHI6 DDX20 S542 ochoa Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
Q9ULI0 ATAD2B S1379 ochoa ATPase family AAA domain-containing protein 2B None
Q9ULU4 ZMYND8 S465 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UMS6 SYNPO2 S820 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UPN9 TRIM33 S852 ochoa E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
Q9UQR1 ZNF148 S336 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9UQR1 ZNF148 S727 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y210 TRPC6 S840 ochoa Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}.
Q9Y228 TRAF3IP3 S120 ochoa TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}.
Q9Y2W1 THRAP3 S468 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y4I1 MYO5A S1452 ochoa Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}.
Q9Y6Y8 SEC23IP S728 ochoa SEC23-interacting protein (p125) Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}.
Q7Z2W4 ZC3HAV1 S640 Sugiyama Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q8N6N3 C1orf52 S129 Sugiyama UPF0690 protein C1orf52 (BCL10-associated gene protein) None
P55010 EIF5 S174 SIGNOR|iPTMNet Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
Q05513 PRKCZ S486 Sugiyama Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}.
Q9UPN9 TRIM33 S949 Sugiyama E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
O95263 PDE8B S428 Sugiyama High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Q9Y6E0 STK24 S357 Sugiyama Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.
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reactome_id name p -log10_p
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.000002 5.744
R-HSA-3700989 Transcriptional Regulation by TP53 0.000049 4.311
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.000844 3.074
R-HSA-9700206 Signaling by ALK in cancer 0.000844 3.074
R-HSA-1059683 Interleukin-6 signaling 0.001361 2.866
R-HSA-193648 NRAGE signals death through JNK 0.001384 2.859
R-HSA-9008059 Interleukin-37 signaling 0.001183 2.927
R-HSA-191859 snRNP Assembly 0.001689 2.772
R-HSA-194441 Metabolism of non-coding RNA 0.001689 2.772
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.002474 2.607
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.002443 2.612
R-HSA-5210891 Uptake and function of anthrax toxins 0.002818 2.550
R-HSA-3214841 PKMTs methylate histone lysines 0.003329 2.478
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.003792 2.421
R-HSA-162599 Late Phase of HIV Life Cycle 0.004380 2.359
R-HSA-1640170 Cell Cycle 0.005090 2.293
R-HSA-75153 Apoptotic execution phase 0.005033 2.298
R-HSA-416482 G alpha (12/13) signalling events 0.004868 2.313
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.005888 2.230
R-HSA-446652 Interleukin-1 family signaling 0.006037 2.219
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.007917 2.101
R-HSA-6783589 Interleukin-6 family signaling 0.006643 2.178
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.008604 2.065
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.008604 2.065
R-HSA-69278 Cell Cycle, Mitotic 0.007623 2.118
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.008198 2.086
R-HSA-162587 HIV Life Cycle 0.007023 2.153
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.007321 2.135
R-HSA-5357801 Programmed Cell Death 0.008015 2.096
R-HSA-5633007 Regulation of TP53 Activity 0.007670 2.115
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.008653 2.063
R-HSA-5620971 Pyroptosis 0.009325 2.030
R-HSA-418360 Platelet calcium homeostasis 0.010080 1.997
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.012466 1.904
R-HSA-4839744 Signaling by APC mutants 0.013676 1.864
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.013676 1.864
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.013676 1.864
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.013676 1.864
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.015572 1.808
R-HSA-5339716 Signaling by GSK3beta mutants 0.015572 1.808
R-HSA-4839748 Signaling by AMER1 mutants 0.015572 1.808
R-HSA-4839735 Signaling by AXIN mutants 0.015572 1.808
R-HSA-418359 Reduction of cytosolic Ca++ levels 0.015572 1.808
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.012555 1.901
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.015572 1.808
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.012672 1.897
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.012672 1.897
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.012672 1.897
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.012555 1.901
R-HSA-193704 p75 NTR receptor-mediated signalling 0.013134 1.882
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.017574 1.755
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.017574 1.755
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.017574 1.755
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.017574 1.755
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.017574 1.755
R-HSA-114604 GPVI-mediated activation cascade 0.017387 1.760
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.018385 1.736
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.018977 1.722
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.020468 1.689
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.021466 1.668
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.024778 1.606
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.024778 1.606
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.024778 1.606
R-HSA-196299 Beta-catenin phosphorylation cascade 0.024184 1.616
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.021900 1.660
R-HSA-167161 HIV Transcription Initiation 0.024373 1.613
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.024373 1.613
R-HSA-73776 RNA Polymerase II Promoter Escape 0.026992 1.569
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.024373 1.613
R-HSA-77042 Formation of editosomes by ADAR proteins 0.024778 1.606
R-HSA-418885 DCC mediated attractive signaling 0.024184 1.616
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.023118 1.636
R-HSA-391160 Signal regulatory protein family interactions 0.021883 1.660
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.023466 1.630
R-HSA-109581 Apoptosis 0.026986 1.569
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.027061 1.568
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.027061 1.568
R-HSA-373752 Netrin-1 signaling 0.028355 1.547
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.029377 1.532
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.029377 1.532
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.029754 1.526
R-HSA-6783310 Fanconi Anemia Pathway 0.029754 1.526
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.029754 1.526
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.034167 1.466
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.034309 1.465
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.037056 1.431
R-HSA-162906 HIV Infection 0.037478 1.426
R-HSA-74160 Gene expression (Transcription) 0.038178 1.418
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.045778 1.339
R-HSA-9909396 Circadian clock 0.039873 1.399
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.039885 1.399
R-HSA-201681 TCF dependent signaling in response to WNT 0.043253 1.364
R-HSA-5339562 Uptake and actions of bacterial toxins 0.040548 1.392
R-HSA-190374 FGFR1c and Klotho ligand binding and activation 0.084082 1.075
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.095505 1.020
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.106787 0.971
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 0.139797 0.855
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.181930 0.740
R-HSA-190375 FGFR2c ligand binding and activation 0.192139 0.716
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.192139 0.716
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.072145 1.142
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.075720 1.121
R-HSA-190372 FGFR3c ligand binding and activation 0.202220 0.694
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.202220 0.694
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.079350 1.100
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.079350 1.100
R-HSA-9027284 Erythropoietin activates RAS 0.212177 0.673
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.212177 0.673
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.212177 0.673
R-HSA-1855170 IPs transport between nucleus and cytosol 0.086768 1.062
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.086768 1.062
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.090553 1.043
R-HSA-5656121 Translesion synthesis by POLI 0.222009 0.654
R-HSA-5696400 Dual Incision in GG-NER 0.094385 1.025
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.098263 1.008
R-HSA-5655862 Translesion synthesis by POLK 0.231720 0.635
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.231720 0.635
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.241310 0.617
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.241310 0.617
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.114202 0.942
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.250781 0.601
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.118285 0.927
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.260134 0.585
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.269371 0.570
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.269371 0.570
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.269371 0.570
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.269371 0.570
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.269371 0.570
R-HSA-5654704 SHC-mediated cascade:FGFR3 0.278494 0.555
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.278494 0.555
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.278494 0.555
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.082819 1.082
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.104984 0.979
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.115510 0.937
R-HSA-141424 Amplification of signal from the kinetochores 0.115510 0.937
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.224006 0.650
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.224006 0.650
R-HSA-8854518 AURKA Activation by TPX2 0.237817 0.624
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.192020 0.717
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.270172 0.568
R-HSA-6798695 Neutrophil degranulation 0.253383 0.596
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.086768 1.062
R-HSA-5654710 PI-3K cascade:FGFR3 0.260134 0.585
R-HSA-5654720 PI-3K cascade:FGFR4 0.269371 0.570
R-HSA-69618 Mitotic Spindle Checkpoint 0.164163 0.785
R-HSA-73893 DNA Damage Bypass 0.160866 0.794
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.055169 1.258
R-HSA-110312 Translesion synthesis by REV1 0.212177 0.673
R-HSA-156711 Polo-like kinase mediated events 0.250781 0.601
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.118285 0.927
R-HSA-68962 Activation of the pre-replicative complex 0.075720 1.121
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.094385 1.025
R-HSA-933542 TRAF6 mediated NF-kB activation 0.055169 1.258
R-HSA-69166 Removal of the Flap Intermediate 0.202220 0.694
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.241310 0.617
R-HSA-110320 Translesion Synthesis by POLH 0.260134 0.585
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.152204 0.818
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.114202 0.942
R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 0.117928 0.928
R-HSA-190373 FGFR1c ligand binding and activation 0.192139 0.716
R-HSA-190239 FGFR3 ligand binding and activation 0.212177 0.673
R-HSA-176187 Activation of ATR in response to replication stress 0.086768 1.062
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.086768 1.062
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.231720 0.635
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.278494 0.555
R-HSA-1221632 Meiotic synapsis 0.178597 0.748
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.256294 0.591
R-HSA-5693538 Homology Directed Repair 0.230794 0.637
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.061772 1.209
R-HSA-190242 FGFR1 ligand binding and activation 0.250781 0.601
R-HSA-4791275 Signaling by WNT in cancer 0.083033 1.081
R-HSA-5635838 Activation of SMO 0.222009 0.654
R-HSA-5655302 Signaling by FGFR1 in disease 0.126559 0.898
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.242431 0.615
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.102186 0.991
R-HSA-74158 RNA Polymerase III Transcription 0.102186 0.991
R-HSA-75064 mRNA Editing: A to I Conversion 0.048945 1.310
R-HSA-75102 C6 deamination of adenosine 0.048945 1.310
R-HSA-68689 CDC6 association with the ORC:origin complex 0.095505 1.020
R-HSA-428543 Inactivation of CDC42 and RAC1 0.139797 0.855
R-HSA-192814 vRNA Synthesis 0.161127 0.793
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.161127 0.793
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.171594 0.765
R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.171594 0.765
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.181930 0.740
R-HSA-190322 FGFR4 ligand binding and activation 0.192139 0.716
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.192139 0.716
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.072145 1.142
R-HSA-162588 Budding and maturation of HIV virion 0.079350 1.100
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.094385 1.025
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.106151 0.974
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.250781 0.601
R-HSA-73980 RNA Polymerase III Transcription Termination 0.250781 0.601
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.143492 0.843
R-HSA-1500620 Meiosis 0.112842 0.948
R-HSA-1226099 Signaling by FGFR in disease 0.274798 0.561
R-HSA-2871796 FCERI mediated MAPK activation 0.204764 0.689
R-HSA-69183 Processive synthesis on the lagging strand 0.212177 0.673
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.110198 0.958
R-HSA-390648 Muscarinic acetylcholine receptors 0.084082 1.075
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.117928 0.928
R-HSA-9020956 Interleukin-27 signaling 0.150529 0.822
R-HSA-8875555 MET activates RAP1 and RAC1 0.150529 0.822
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.090553 1.043
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.110157 0.958
R-HSA-190241 FGFR2 ligand binding and activation 0.278494 0.555
R-HSA-912446 Meiotic recombination 0.169692 0.770
R-HSA-9707616 Heme signaling 0.219416 0.659
R-HSA-8984722 Interleukin-35 Signalling 0.181930 0.740
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.192139 0.716
R-HSA-69481 G2/M Checkpoints 0.264111 0.578
R-HSA-73894 DNA Repair 0.202517 0.694
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.098263 1.008
R-HSA-9754189 Germ layer formation at gastrulation 0.260134 0.585
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.247049 0.607
R-HSA-1839124 FGFR1 mutant receptor activation 0.086768 1.062
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.068264 1.166
R-HSA-75072 mRNA Editing 0.139797 0.855
R-HSA-112411 MAPK1 (ERK2) activation 0.139797 0.855
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.171594 0.765
R-HSA-1839130 Signaling by activated point mutants of FGFR3 0.192139 0.716
R-HSA-9615710 Late endosomal microautophagy 0.072145 1.142
R-HSA-168325 Viral Messenger RNA Synthesis 0.214834 0.668
R-HSA-68877 Mitotic Prometaphase 0.129806 0.887
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.240712 0.619
R-HSA-69275 G2/M Transition 0.257227 0.590
R-HSA-2033519 Activated point mutants of FGFR2 0.250781 0.601
R-HSA-453274 Mitotic G2-G2/M phases 0.262699 0.581
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.192139 0.716
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.202220 0.694
R-HSA-180746 Nuclear import of Rev protein 0.094385 1.025
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.098263 1.008
R-HSA-72613 Eukaryotic Translation Initiation 0.224226 0.649
R-HSA-72737 Cap-dependent Translation Initiation 0.224226 0.649
R-HSA-69186 Lagging Strand Synthesis 0.278494 0.555
R-HSA-3928662 EPHB-mediated forward signaling 0.139214 0.856
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.082819 1.082
R-HSA-167172 Transcription of the HIV genome 0.071492 1.146
R-HSA-69620 Cell Cycle Checkpoints 0.062643 1.203
R-HSA-9927353 Co-inhibition by BTLA 0.084082 1.075
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.139797 0.855
R-HSA-110056 MAPK3 (ERK1) activation 0.150529 0.822
R-HSA-877312 Regulation of IFNG signaling 0.181930 0.740
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.181930 0.740
R-HSA-177243 Interactions of Rev with host cellular proteins 0.118285 0.927
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.118285 0.927
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.122405 0.912
R-HSA-113510 E2F mediated regulation of DNA replication 0.260134 0.585
R-HSA-2428928 IRS-related events triggered by IGF1R 0.214834 0.668
R-HSA-69473 G2/M DNA damage checkpoint 0.274798 0.561
R-HSA-68882 Mitotic Anaphase 0.176854 0.752
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.178943 0.747
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.051160 1.291
R-HSA-9609646 HCMV Infection 0.252426 0.598
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.241310 0.617
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.059418 1.226
R-HSA-2172127 DAP12 interactions 0.139214 0.856
R-HSA-9610379 HCMV Late Events 0.178845 0.748
R-HSA-9675135 Diseases of DNA repair 0.147798 0.830
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.220956 0.656
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.161127 0.793
R-HSA-9005895 Pervasive developmental disorders 0.181930 0.740
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.181930 0.740
R-HSA-9697154 Disorders of Nervous System Development 0.181930 0.740
R-HSA-2033514 FGFR3 mutant receptor activation 0.192139 0.716
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.212177 0.673
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.241310 0.617
R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.241310 0.617
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.110157 0.958
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.147798 0.830
R-HSA-5578749 Transcriptional regulation by small RNAs 0.265546 0.576
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.195187 0.710
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.262699 0.581
R-HSA-450294 MAP kinase activation 0.056921 1.245
R-HSA-68886 M Phase 0.136570 0.865
R-HSA-194138 Signaling by VEGF 0.257393 0.589
R-HSA-445144 Signal transduction by L1 0.269371 0.570
R-HSA-1474165 Reproduction 0.277609 0.557
R-HSA-2682334 EPH-Ephrin signaling 0.137673 0.861
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.057018 1.244
R-HSA-5358508 Mismatch Repair 0.250781 0.601
R-HSA-2428924 IGF1R signaling cascade 0.228603 0.641
R-HSA-199991 Membrane Trafficking 0.221102 0.655
R-HSA-448424 Interleukin-17 signaling 0.075934 1.120
R-HSA-73884 Base Excision Repair 0.129197 0.889
R-HSA-140342 Apoptosis induced DNA fragmentation 0.150529 0.822
R-HSA-9675151 Disorders of Developmental Biology 0.231720 0.635
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.114202 0.942
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.183077 0.737
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.087553 1.058
R-HSA-909733 Interferon alpha/beta signaling 0.220956 0.656
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.233207 0.632
R-HSA-170968 Frs2-mediated activation 0.192139 0.716
R-HSA-2980766 Nuclear Envelope Breakdown 0.196610 0.706
R-HSA-2559580 Oxidative Stress Induced Senescence 0.170246 0.769
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.150529 0.822
R-HSA-210990 PECAM1 interactions 0.161127 0.793
R-HSA-9856872 Malate-aspartate shuttle 0.202220 0.694
R-HSA-912631 Regulation of signaling by CBL 0.260134 0.585
R-HSA-6784531 tRNA processing in the nucleus 0.219416 0.659
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.170246 0.769
R-HSA-195721 Signaling by WNT 0.211579 0.675
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.047486 1.323
R-HSA-168255 Influenza Infection 0.105418 0.977
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.176392 0.754
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.048165 1.317
R-HSA-168898 Toll-like Receptor Cascades 0.126175 0.899
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.117928 0.928
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.192139 0.716
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.202220 0.694
R-HSA-1433559 Regulation of KIT signaling 0.202220 0.694
R-HSA-936837 Ion transport by P-type ATPases 0.228603 0.641
R-HSA-162582 Signal Transduction 0.051235 1.290
R-HSA-432142 Platelet sensitization by LDL 0.250781 0.601
R-HSA-169893 Prolonged ERK activation events 0.222009 0.654
R-HSA-1834941 STING mediated induction of host immune responses 0.260134 0.585
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.130746 0.884
R-HSA-3371556 Cellular response to heat stress 0.240712 0.619
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.139797 0.855
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.192139 0.716
R-HSA-9833482 PKR-mediated signaling 0.099872 1.001
R-HSA-73857 RNA Polymerase II Transcription 0.059986 1.222
R-HSA-449147 Signaling by Interleukins 0.115083 0.939
R-HSA-418346 Platelet homeostasis 0.062496 1.204
R-HSA-3247509 Chromatin modifying enzymes 0.102210 0.991
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.068792 1.162
R-HSA-166166 MyD88-independent TLR4 cascade 0.068792 1.162
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.075934 1.120
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.060972 1.215
R-HSA-913531 Interferon Signaling 0.246034 0.609
R-HSA-9006936 Signaling by TGFB family members 0.186297 0.730
R-HSA-1280215 Cytokine Signaling in Immune system 0.214929 0.668
R-HSA-4839726 Chromatin organization 0.124526 0.905
R-HSA-1538133 G0 and Early G1 0.083033 1.081
R-HSA-9694631 Maturation of nucleoprotein 0.260134 0.585
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.210262 0.677
R-HSA-2262752 Cellular responses to stress 0.233419 0.632
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.066958 1.174
R-HSA-212436 Generic Transcription Pathway 0.089438 1.048
R-HSA-186763 Downstream signal transduction 0.079350 1.100
R-HSA-8953750 Transcriptional Regulation by E2F6 0.114202 0.942
R-HSA-9705683 SARS-CoV-2-host interactions 0.202508 0.694
R-HSA-5578775 Ion homeostasis 0.192084 0.717
R-HSA-9856651 MITF-M-dependent gene expression 0.061874 1.208
R-HSA-9020702 Interleukin-1 signaling 0.167196 0.777
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.139214 0.856
R-HSA-9730414 MITF-M-regulated melanocyte development 0.170646 0.768
R-HSA-5218859 Regulated Necrosis 0.071492 1.146
R-HSA-9711123 Cellular response to chemical stress 0.155898 0.807
R-HSA-186797 Signaling by PDGF 0.219416 0.659
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.048837 1.311
R-HSA-9694516 SARS-CoV-2 Infection 0.095145 1.022
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.201149 0.696
R-HSA-73887 Death Receptor Signaling 0.066958 1.174
R-HSA-380287 Centrosome maturation 0.279422 0.554
R-HSA-1169408 ISG15 antiviral mechanism 0.279422 0.554
R-HSA-9843745 Adipogenesis 0.280994 0.551
R-HSA-422475 Axon guidance 0.281881 0.550
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.287503 0.541
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.287503 0.541
R-HSA-5654719 SHC-mediated cascade:FGFR4 0.287503 0.541
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.287503 0.541
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.287503 0.541
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.296400 0.528
R-HSA-5654689 PI-3K cascade:FGFR1 0.296400 0.528
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.296400 0.528
R-HSA-350054 Notch-HLH transcription pathway 0.296400 0.528
R-HSA-166208 mTORC1-mediated signalling 0.296400 0.528
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.296400 0.528
R-HSA-112409 RAF-independent MAPK1/3 activation 0.296400 0.528
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.296400 0.528
R-HSA-189200 Cellular hexose transport 0.296400 0.528
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.302500 0.519
R-HSA-912526 Interleukin receptor SHC signaling 0.305186 0.515
R-HSA-982772 Growth hormone receptor signaling 0.305186 0.515
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.305186 0.515
R-HSA-5693607 Processing of DNA double-strand break ends 0.307102 0.513
R-HSA-76002 Platelet activation, signaling and aggregation 0.309904 0.509
R-HSA-5654688 SHC-mediated cascade:FGFR1 0.313863 0.503
R-HSA-9707564 Cytoprotection by HMOX1 0.316289 0.500
R-HSA-1632852 Macroautophagy 0.318423 0.497
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.320873 0.494
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.322433 0.492
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.322433 0.492
R-HSA-5654695 PI-3K cascade:FGFR2 0.322433 0.492
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.322433 0.492
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.325247 0.488
R-HSA-8856828 Clathrin-mediated endocytosis 0.328659 0.483
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.330896 0.480
R-HSA-5689901 Metalloprotease DUBs 0.330896 0.480
R-HSA-3295583 TRP channels 0.330896 0.480
R-HSA-70635 Urea cycle 0.330896 0.480
R-HSA-525793 Myogenesis 0.330896 0.480
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.334577 0.476
R-HSA-5654699 SHC-mediated cascade:FGFR2 0.339253 0.469
R-HSA-73863 RNA Polymerase I Transcription Termination 0.339253 0.469
R-HSA-5655332 Signaling by FGFR3 in disease 0.339253 0.469
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.339253 0.469
R-HSA-264876 Insulin processing 0.339253 0.469
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.343669 0.464
R-HSA-156902 Peptide chain elongation 0.343669 0.464
R-HSA-9675108 Nervous system development 0.345689 0.461
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.347507 0.459
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.347507 0.459
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.347507 0.459
R-HSA-1236974 ER-Phagosome pathway 0.348200 0.458
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.352721 0.453
R-HSA-5654708 Downstream signaling of activated FGFR3 0.355659 0.449
R-HSA-5656169 Termination of translesion DNA synthesis 0.355659 0.449
R-HSA-9006335 Signaling by Erythropoietin 0.355659 0.449
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.355659 0.449
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.355929 0.449
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.357231 0.447
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.361730 0.442
R-HSA-5693532 DNA Double-Strand Break Repair 0.362729 0.440
R-HSA-5654716 Downstream signaling of activated FGFR4 0.363708 0.439
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.363708 0.439
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.363708 0.439
R-HSA-2424491 DAP12 signaling 0.363708 0.439
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.363708 0.439
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.363708 0.439
R-HSA-114452 Activation of BH3-only proteins 0.363708 0.439
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.366125 0.436
R-HSA-156842 Eukaryotic Translation Elongation 0.366217 0.436
R-HSA-9612973 Autophagy 0.372908 0.428
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.379509 0.421
R-HSA-69190 DNA strand elongation 0.379509 0.421
R-HSA-9675126 Diseases of mitotic cell cycle 0.379509 0.421
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.379605 0.421
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.379605 0.421
R-HSA-9711097 Cellular response to starvation 0.379678 0.421
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.384042 0.416
R-HSA-72764 Eukaryotic Translation Termination 0.384042 0.416
R-HSA-72689 Formation of a pool of free 40S subunits 0.384042 0.416
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.387263 0.412
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.387263 0.412
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.387263 0.412
R-HSA-354192 Integrin signaling 0.387263 0.412
R-HSA-9022692 Regulation of MECP2 expression and activity 0.387263 0.412
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.387263 0.412
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.387263 0.412
R-HSA-8953854 Metabolism of RNA 0.388580 0.411
R-HSA-72312 rRNA processing 0.389102 0.410
R-HSA-8953897 Cellular responses to stimuli 0.392213 0.406
R-HSA-5693537 Resolution of D-Loop Structures 0.394920 0.403
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.394920 0.403
R-HSA-114508 Effects of PIP2 hydrolysis 0.394920 0.403
R-HSA-189483 Heme degradation 0.394920 0.403
R-HSA-2467813 Separation of Sister Chromatids 0.399888 0.398
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.402481 0.395
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.402481 0.395
R-HSA-168638 NOD1/2 Signaling Pathway 0.402481 0.395
R-HSA-5610787 Hedgehog 'off' state 0.406014 0.391
R-HSA-70171 Glycolysis 0.406014 0.391
R-HSA-5654687 Downstream signaling of activated FGFR1 0.409949 0.387
R-HSA-5654696 Downstream signaling of activated FGFR2 0.409949 0.387
R-HSA-169911 Regulation of Apoptosis 0.409949 0.387
R-HSA-187687 Signalling to ERKs 0.409949 0.387
R-HSA-2408557 Selenocysteine synthesis 0.410364 0.387
R-HSA-1500931 Cell-Cell communication 0.413498 0.384
R-HSA-9682385 FLT3 signaling in disease 0.417324 0.380
R-HSA-1839126 FGFR2 mutant receptor activation 0.417324 0.380
R-HSA-3371511 HSF1 activation 0.417324 0.380
R-HSA-192823 Viral mRNA Translation 0.419017 0.378
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.423234 0.373
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.423319 0.373
R-HSA-110331 Cleavage of the damaged purine 0.424607 0.372
R-HSA-549127 SLC-mediated transport of organic cations 0.424607 0.372
R-HSA-5689896 Ovarian tumor domain proteases 0.424607 0.372
R-HSA-73927 Depurination 0.431800 0.365
R-HSA-8875878 MET promotes cell motility 0.431800 0.365
R-HSA-5696398 Nucleotide Excision Repair 0.431875 0.365
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.433147 0.363
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.433147 0.363
R-HSA-9679506 SARS-CoV Infections 0.435444 0.361
R-HSA-71336 Pentose phosphate pathway 0.438903 0.358
R-HSA-201556 Signaling by ALK 0.438903 0.358
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.440363 0.356
R-HSA-69239 Synthesis of DNA 0.440363 0.356
R-HSA-211000 Gene Silencing by RNA 0.440363 0.356
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.444581 0.352
R-HSA-1236975 Antigen processing-Cross presentation 0.444581 0.352
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.445917 0.351
R-HSA-5260271 Diseases of Immune System 0.445917 0.351
R-HSA-1251985 Nuclear signaling by ERBB4 0.445917 0.351
R-HSA-202433 Generation of second messenger molecules 0.445917 0.351
R-HSA-451927 Interleukin-2 family signaling 0.445917 0.351
R-HSA-69002 DNA Replication Pre-Initiation 0.448782 0.348
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.452845 0.344
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.452845 0.344
R-HSA-2559583 Cellular Senescence 0.456030 0.341
R-HSA-9932298 Degradation of CRY and PER proteins 0.459686 0.338
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.459686 0.338
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.459686 0.338
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.459686 0.338
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.459686 0.338
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.461276 0.336
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.461276 0.336
R-HSA-1483249 Inositol phosphate metabolism 0.461276 0.336
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.465404 0.332
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.466442 0.331
R-HSA-165159 MTOR signalling 0.466442 0.331
R-HSA-5653656 Vesicle-mediated transport 0.468071 0.330
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.469513 0.328
R-HSA-5654743 Signaling by FGFR4 0.473114 0.325
R-HSA-1433557 Signaling by SCF-KIT 0.473114 0.325
R-HSA-9824446 Viral Infection Pathways 0.473507 0.325
R-HSA-69236 G1 Phase 0.479703 0.319
R-HSA-69231 Cyclin D associated events in G1 0.479703 0.319
R-HSA-375280 Amine ligand-binding receptors 0.479703 0.319
R-HSA-983712 Ion channel transport 0.484870 0.314
R-HSA-5654741 Signaling by FGFR3 0.486210 0.313
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.486210 0.313
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.486210 0.313
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.486210 0.313
R-HSA-70326 Glucose metabolism 0.489775 0.310
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.493770 0.306
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.498983 0.302
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.498983 0.302
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.498983 0.302
R-HSA-68875 Mitotic Prophase 0.501699 0.300
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.505250 0.296
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.505634 0.296
R-HSA-9609690 HCMV Early Events 0.506792 0.295
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.506792 0.295
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.511439 0.291
R-HSA-162909 Host Interactions of HIV factors 0.517317 0.286
R-HSA-5655253 Signaling by FGFR2 in disease 0.517551 0.286
R-HSA-109704 PI3K Cascade 0.517551 0.286
R-HSA-9748787 Azathioprine ADME 0.517551 0.286
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.517838 0.286
R-HSA-69206 G1/S Transition 0.525004 0.280
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.528225 0.277
R-HSA-376176 Signaling by ROBO receptors 0.528225 0.277
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.529548 0.276
R-HSA-72187 mRNA 3'-end processing 0.529548 0.276
R-HSA-73772 RNA Polymerase I Promoter Escape 0.529548 0.276
R-HSA-112382 Formation of RNA Pol II elongation complex 0.529548 0.276
R-HSA-68949 Orc1 removal from chromatin 0.529548 0.276
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.529548 0.276
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.535434 0.271
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.535434 0.271
R-HSA-9639288 Amino acids regulate mTORC1 0.535434 0.271
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.535434 0.271
R-HSA-445355 Smooth Muscle Contraction 0.535434 0.271
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.541247 0.267
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.543160 0.265
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.546988 0.262
R-HSA-3214815 HDACs deacetylate histones 0.546988 0.262
R-HSA-9753281 Paracetamol ADME 0.546988 0.262
R-HSA-5576891 Cardiac conduction 0.551257 0.259
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.552658 0.258
R-HSA-5654736 Signaling by FGFR1 0.552658 0.258
R-HSA-72702 Ribosomal scanning and start codon recognition 0.552658 0.258
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.552658 0.258
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.552658 0.258
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.552658 0.258
R-HSA-397014 Muscle contraction 0.557932 0.253
R-HSA-112399 IRS-mediated signalling 0.558257 0.253
R-HSA-6782135 Dual incision in TC-NER 0.563786 0.249
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.563786 0.249
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.569246 0.245
R-HSA-180786 Extension of Telomeres 0.569246 0.245
R-HSA-8873719 RAB geranylgeranylation 0.574638 0.241
R-HSA-8943724 Regulation of PTEN gene transcription 0.574638 0.241
R-HSA-156590 Glutathione conjugation 0.574638 0.241
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.574638 0.241
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.574638 0.241
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.574638 0.241
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.574638 0.241
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.574638 0.241
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.574638 0.241
R-HSA-418990 Adherens junctions interactions 0.575213 0.240
R-HSA-73856 RNA Polymerase II Transcription Termination 0.579963 0.237
R-HSA-9948299 Ribosome-associated quality control 0.579995 0.237
R-HSA-5358351 Signaling by Hedgehog 0.579995 0.237
R-HSA-8951664 Neddylation 0.583695 0.234
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.585222 0.233
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.585222 0.233
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.585222 0.233
R-HSA-9664407 Parasite infection 0.586966 0.231
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.586966 0.231
R-HSA-9664417 Leishmania phagocytosis 0.586966 0.231
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.590415 0.229
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.590415 0.229
R-HSA-8848021 Signaling by PTK6 0.590415 0.229
R-HSA-69615 G1/S DNA Damage Checkpoints 0.590415 0.229
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.590420 0.229
R-HSA-5690714 CD22 mediated BCR regulation 0.595543 0.225
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.595543 0.225
R-HSA-74751 Insulin receptor signalling cascade 0.595543 0.225
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.600608 0.221
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.605609 0.218
R-HSA-5693606 DNA Double Strand Break Response 0.610549 0.214
R-HSA-69242 S Phase 0.617279 0.210
R-HSA-204005 COPII-mediated vesicle transport 0.625000 0.204
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.625000 0.204
R-HSA-212165 Epigenetic regulation of gene expression 0.625849 0.204
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.629697 0.201
R-HSA-453276 Regulation of mitotic cell cycle 0.629697 0.201
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.629697 0.201
R-HSA-427413 NoRC negatively regulates rRNA expression 0.629697 0.201
R-HSA-5632684 Hedgehog 'on' state 0.629697 0.201
R-HSA-189445 Metabolism of porphyrins 0.629697 0.201
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.630196 0.201
R-HSA-69306 DNA Replication 0.633372 0.198
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.634336 0.198
R-HSA-157118 Signaling by NOTCH 0.634878 0.197
R-HSA-69052 Switching of origins to a post-replicative state 0.638917 0.195
R-HSA-1989781 PPARA activates gene expression 0.639661 0.194
R-HSA-1236394 Signaling by ERBB4 0.643441 0.191
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.645864 0.190
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.647909 0.188
R-HSA-8852135 Protein ubiquitination 0.647909 0.188
R-HSA-71403 Citric acid cycle (TCA cycle) 0.647909 0.188
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.647909 0.188
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.652321 0.186
R-HSA-1980143 Signaling by NOTCH1 0.652321 0.186
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.656677 0.183
R-HSA-9694635 Translation of Structural Proteins 0.656677 0.183
R-HSA-73864 RNA Polymerase I Transcription 0.660980 0.180
R-HSA-383280 Nuclear Receptor transcription pathway 0.660980 0.180
R-HSA-421270 Cell-cell junction organization 0.662453 0.179
R-HSA-5663205 Infectious disease 0.665152 0.177
R-HSA-2408522 Selenoamino acid metabolism 0.666916 0.176
R-HSA-5654738 Signaling by FGFR2 0.669425 0.174
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.669425 0.174
R-HSA-6806834 Signaling by MET 0.669425 0.174
R-HSA-5688426 Deubiquitination 0.672102 0.173
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.673568 0.172
R-HSA-5619102 SLC transporter disorders 0.675626 0.170
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.685691 0.164
R-HSA-72306 tRNA processing 0.686952 0.163
R-HSA-6802957 Oncogenic MAPK signaling 0.689632 0.161
R-HSA-5687128 MAPK6/MAPK4 signaling 0.689632 0.161
R-HSA-416476 G alpha (q) signalling events 0.693072 0.159
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.693524 0.159
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.697953 0.156
R-HSA-9678108 SARS-CoV-1 Infection 0.700653 0.154
R-HSA-447115 Interleukin-12 family signaling 0.701161 0.154
R-HSA-438064 Post NMDA receptor activation events 0.701161 0.154
R-HSA-8986944 Transcriptional Regulation by MECP2 0.715874 0.145
R-HSA-74752 Signaling by Insulin receptor 0.722957 0.141
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.722957 0.141
R-HSA-446728 Cell junction organization 0.723670 0.140
R-HSA-1643685 Disease 0.724250 0.140
R-HSA-168249 Innate Immune System 0.724364 0.140
R-HSA-68867 Assembly of the pre-replicative complex 0.726433 0.139
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.726433 0.139
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.729865 0.137
R-HSA-9837999 Mitochondrial protein degradation 0.729865 0.137
R-HSA-5617833 Cilium Assembly 0.738803 0.131
R-HSA-157579 Telomere Maintenance 0.743170 0.129
R-HSA-8957275 Post-translational protein phosphorylation 0.746394 0.127
R-HSA-190236 Signaling by FGFR 0.746394 0.127
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.747957 0.126
R-HSA-72163 mRNA Splicing - Major Pathway 0.748253 0.126
R-HSA-9614085 FOXO-mediated transcription 0.749576 0.125
R-HSA-3214847 HATs acetylate histones 0.749576 0.125
R-HSA-9009391 Extra-nuclear estrogen signaling 0.755824 0.122
R-HSA-1257604 PIP3 activates AKT signaling 0.757583 0.121
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.758889 0.120
R-HSA-1483255 PI Metabolism 0.758889 0.120
R-HSA-389948 Co-inhibition by PD-1 0.761879 0.118
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.767856 0.115
R-HSA-5619507 Activation of HOX genes during differentiation 0.767856 0.115
R-HSA-72172 mRNA Splicing 0.772745 0.112
R-HSA-2672351 Stimuli-sensing channels 0.779299 0.108
R-HSA-388396 GPCR downstream signalling 0.784129 0.106
R-HSA-202403 TCR signaling 0.784808 0.105
R-HSA-109582 Hemostasis 0.795415 0.099
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.797989 0.098
R-HSA-168256 Immune System 0.798750 0.098
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.800528 0.097
R-HSA-9748784 Drug ADME 0.800904 0.096
R-HSA-1852241 Organelle biogenesis and maintenance 0.801299 0.096
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.803034 0.095
R-HSA-373760 L1CAM interactions 0.805509 0.094
R-HSA-9007101 Rab regulation of trafficking 0.807953 0.093
R-HSA-1592230 Mitochondrial biogenesis 0.807953 0.093
R-HSA-2980736 Peptide hormone metabolism 0.807953 0.093
R-HSA-1266738 Developmental Biology 0.814554 0.089
R-HSA-8878171 Transcriptional regulation by RUNX1 0.815575 0.089
R-HSA-73886 Chromosome Maintenance 0.817428 0.088
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.821990 0.085
R-HSA-6809371 Formation of the cornified envelope 0.824228 0.084
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.828620 0.082
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.828620 0.082
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.828620 0.082
R-HSA-9006925 Intracellular signaling by second messengers 0.834146 0.079
R-HSA-8939211 ESR-mediated signaling 0.834175 0.079
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.835005 0.078
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.839129 0.076
R-HSA-5683057 MAPK family signaling cascades 0.840929 0.075
R-HSA-5619115 Disorders of transmembrane transporters 0.849602 0.071
R-HSA-9018519 Estrogen-dependent gene expression 0.854626 0.068
R-HSA-163685 Integration of energy metabolism 0.854626 0.068
R-HSA-6807070 PTEN Regulation 0.860046 0.065
R-HSA-9006931 Signaling by Nuclear Receptors 0.861056 0.065
R-HSA-388841 Regulation of T cell activation by CD28 family 0.862364 0.064
R-HSA-372790 Signaling by GPCR 0.864859 0.063
R-HSA-199977 ER to Golgi Anterograde Transport 0.875129 0.058
R-HSA-166520 Signaling by NTRKs 0.876702 0.057
R-HSA-9758941 Gastrulation 0.878255 0.056
R-HSA-9824439 Bacterial Infection Pathways 0.890965 0.050
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.891385 0.050
R-HSA-877300 Interferon gamma signaling 0.892753 0.049
R-HSA-9658195 Leishmania infection 0.892798 0.049
R-HSA-9824443 Parasitic Infection Pathways 0.892798 0.049
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.893875 0.049
R-HSA-5684996 MAPK1/MAPK3 signaling 0.907941 0.042
R-HSA-418555 G alpha (s) signalling events 0.909062 0.041
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.910209 0.041
R-HSA-5689880 Ub-specific processing proteases 0.911342 0.040
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.913565 0.039
R-HSA-611105 Respiratory electron transport 0.916796 0.038
R-HSA-72766 Translation 0.923054 0.035
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.937089 0.028
R-HSA-428157 Sphingolipid metabolism 0.937884 0.028
R-HSA-948021 Transport to the Golgi and subsequent modification 0.938669 0.027
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.939398 0.027
R-HSA-597592 Post-translational protein modification 0.940760 0.027
R-HSA-6805567 Keratinization 0.942449 0.026
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.946679 0.024
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.957059 0.019
R-HSA-1280218 Adaptive Immune System 0.960825 0.017
R-HSA-202733 Cell surface interactions at the vascular wall 0.961221 0.017
R-HSA-156580 Phase II - Conjugation of compounds 0.962197 0.017
R-HSA-425407 SLC-mediated transmembrane transport 0.968541 0.014
R-HSA-5673001 RAF/MAP kinase cascade 0.980036 0.009
R-HSA-1483257 Phospholipid metabolism 0.981511 0.008
R-HSA-112315 Transmission across Chemical Synapses 0.987082 0.006
R-HSA-71291 Metabolism of amino acids and derivatives 0.987658 0.005
R-HSA-392499 Metabolism of proteins 0.988141 0.005
R-HSA-1474244 Extracellular matrix organization 0.988342 0.005
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.989745 0.004
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.994878 0.002
R-HSA-418594 G alpha (i) signalling events 0.995667 0.002
R-HSA-382551 Transport of small molecules 0.995828 0.002
R-HSA-446203 Asparagine N-linked glycosylation 0.996429 0.002
R-HSA-112316 Neuronal System 0.998029 0.001
R-HSA-211859 Biological oxidations 0.999034 0.000
R-HSA-500792 GPCR ligand binding 0.999591 0.000
R-HSA-556833 Metabolism of lipids 0.999996 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.896 0.292 2 0.885
CLK3CLK3 0.890 0.333 1 0.871
MOSMOS 0.882 0.253 1 0.877
PIM3PIM3 0.879 0.159 -3 0.855
CDC7CDC7 0.879 0.092 1 0.860
GRK1GRK1 0.876 0.265 -2 0.798
NDR2NDR2 0.874 0.083 -3 0.869
DSTYKDSTYK 0.873 0.069 2 0.902
PRPKPRPK 0.873 -0.085 -1 0.843
MTORMTOR 0.871 -0.042 1 0.813
IKKBIKKB 0.871 -0.036 -2 0.724
CAMK2GCAMK2G 0.870 0.026 2 0.833
CAMK1BCAMK1B 0.869 0.045 -3 0.865
SKMLCKSKMLCK 0.869 0.150 -2 0.875
BMPR1BBMPR1B 0.869 0.297 1 0.841
RSK2RSK2 0.869 0.125 -3 0.791
NLKNLK 0.869 0.064 1 0.858
RAF1RAF1 0.868 -0.084 1 0.842
FAM20CFAM20C 0.868 0.215 2 0.682
BMPR2BMPR2 0.868 -0.041 -2 0.878
CDKL1CDKL1 0.867 0.067 -3 0.813
KISKIS 0.866 0.127 1 0.729
GCN2GCN2 0.866 -0.169 2 0.810
PIM1PIM1 0.865 0.136 -3 0.791
PDHK4PDHK4 0.865 -0.262 1 0.857
PRKD1PRKD1 0.864 0.066 -3 0.834
MST4MST4 0.864 0.082 2 0.879
ERK5ERK5 0.864 0.049 1 0.831
TGFBR2TGFBR2 0.864 0.029 -2 0.823
ATRATR 0.864 -0.039 1 0.805
LATS1LATS1 0.863 0.221 -3 0.900
IKKAIKKA 0.863 0.038 -2 0.709
TBK1TBK1 0.863 -0.130 1 0.739
GRK6GRK6 0.863 0.112 1 0.853
TGFBR1TGFBR1 0.863 0.209 -2 0.838
PKN3PKN3 0.862 0.013 -3 0.831
CAMLCKCAMLCK 0.862 0.065 -2 0.867
MLK1MLK1 0.862 -0.024 2 0.835
GRK5GRK5 0.862 -0.043 -3 0.853
CDKL5CDKL5 0.861 0.064 -3 0.805
NDR1NDR1 0.861 -0.000 -3 0.851
NUAK2NUAK2 0.861 0.016 -3 0.844
P90RSKP90RSK 0.861 0.055 -3 0.791
SRPK1SRPK1 0.861 0.106 -3 0.761
RIPK3RIPK3 0.861 -0.056 3 0.785
ULK2ULK2 0.860 -0.194 2 0.797
GRK7GRK7 0.860 0.210 1 0.789
IKKEIKKE 0.860 -0.130 1 0.732
NEK6NEK6 0.860 -0.045 -2 0.833
NIKNIK 0.860 -0.039 -3 0.882
CHAK2CHAK2 0.860 0.006 -1 0.815
ICKICK 0.859 0.079 -3 0.849
DAPK2DAPK2 0.859 0.045 -3 0.873
PKN2PKN2 0.859 0.032 -3 0.833
CAMK2BCAMK2B 0.859 0.147 2 0.812
LATS2LATS2 0.859 0.022 -5 0.747
RSK3RSK3 0.859 0.046 -3 0.782
WNK1WNK1 0.858 -0.048 -2 0.868
NEK7NEK7 0.858 -0.137 -3 0.844
CAMK2DCAMK2D 0.858 0.017 -3 0.841
PRKD2PRKD2 0.858 0.059 -3 0.779
HUNKHUNK 0.858 -0.104 2 0.813
PKCDPKCD 0.858 0.073 2 0.810
AURCAURC 0.858 0.135 -2 0.716
PDHK1PDHK1 0.857 -0.256 1 0.833
MARK4MARK4 0.857 -0.032 4 0.837
CLK2CLK2 0.857 0.246 -3 0.759
CAMK2ACAMK2A 0.857 0.131 2 0.820
MAPKAPK2MAPKAPK2 0.857 0.083 -3 0.749
HIPK4HIPK4 0.857 0.039 1 0.797
PKACGPKACG 0.857 0.063 -2 0.774
AMPKA1AMPKA1 0.856 -0.010 -3 0.855
ALK4ALK4 0.856 0.120 -2 0.858
CLK4CLK4 0.855 0.154 -3 0.772
ACVR2BACVR2B 0.854 0.172 -2 0.817
ALK2ALK2 0.854 0.194 -2 0.840
P70S6KBP70S6KB 0.854 0.027 -3 0.804
GRK4GRK4 0.854 -0.039 -2 0.821
RSK4RSK4 0.853 0.118 -3 0.769
CDK1CDK1 0.853 0.157 1 0.684
TSSK2TSSK2 0.853 0.001 -5 0.822
MAPKAPK3MAPKAPK3 0.853 -0.010 -3 0.784
ACVR2AACVR2A 0.853 0.143 -2 0.810
DLKDLK 0.852 -0.091 1 0.843
CDK8CDK8 0.852 0.048 1 0.714
BMPR1ABMPR1A 0.852 0.247 1 0.818
ULK1ULK1 0.852 -0.208 -3 0.804
ATMATM 0.852 -0.019 1 0.734
MLK3MLK3 0.852 0.019 2 0.772
BCKDKBCKDK 0.851 -0.185 -1 0.775
PLK1PLK1 0.851 0.018 -2 0.795
CLK1CLK1 0.851 0.146 -3 0.749
ANKRD3ANKRD3 0.851 -0.098 1 0.846
SRPK2SRPK2 0.850 0.077 -3 0.687
TSSK1TSSK1 0.850 0.010 -3 0.876
CDK5CDK5 0.850 0.139 1 0.737
MASTLMASTL 0.850 -0.270 -2 0.796
PAK1PAK1 0.850 0.033 -2 0.820
AMPKA2AMPKA2 0.850 -0.014 -3 0.828
PKACBPKACB 0.850 0.131 -2 0.727
MSK1MSK1 0.849 0.105 -3 0.758
MSK2MSK2 0.849 0.026 -3 0.754
WNK3WNK3 0.849 -0.278 1 0.809
JNK3JNK3 0.848 0.112 1 0.698
PRKXPRKX 0.847 0.160 -3 0.700
MLK2MLK2 0.847 -0.136 2 0.836
PKCBPKCB 0.847 0.039 2 0.759
CDK19CDK19 0.847 0.050 1 0.679
SRPK3SRPK3 0.847 0.057 -3 0.732
RIPK1RIPK1 0.846 -0.210 1 0.807
MNK2MNK2 0.846 0.032 -2 0.815
AURBAURB 0.846 0.087 -2 0.711
NEK9NEK9 0.846 -0.219 2 0.846
DYRK2DYRK2 0.846 0.070 1 0.720
AURAAURA 0.846 0.111 -2 0.689
PAK3PAK3 0.845 -0.029 -2 0.814
JNK2JNK2 0.845 0.117 1 0.666
CDK7CDK7 0.845 0.037 1 0.720
MYLK4MYLK4 0.845 0.058 -2 0.811
PKRPKR 0.845 -0.014 1 0.829
CAMK4CAMK4 0.845 -0.084 -3 0.822
PKCGPKCG 0.845 0.008 2 0.764
GSK3AGSK3A 0.845 0.233 4 0.625
MLK4MLK4 0.844 -0.022 2 0.742
PKCAPKCA 0.844 0.037 2 0.754
PKG2PKG2 0.844 0.086 -2 0.721
IRE1IRE1 0.844 -0.122 1 0.783
NIM1NIM1 0.844 -0.127 3 0.815
TTBK2TTBK2 0.843 -0.207 2 0.717
PLK3PLK3 0.843 -0.000 2 0.785
MEK1MEK1 0.843 -0.155 2 0.854
PRKD3PRKD3 0.843 -0.002 -3 0.747
YSK4YSK4 0.843 -0.091 1 0.780
CDK13CDK13 0.843 0.046 1 0.694
GRK2GRK2 0.842 0.014 -2 0.712
CDK18CDK18 0.842 0.090 1 0.656
CDK3CDK3 0.842 0.178 1 0.622
IRE2IRE2 0.842 -0.073 2 0.764
VRK2VRK2 0.841 -0.188 1 0.871
GSK3BGSK3B 0.841 0.177 4 0.619
QSKQSK 0.841 -0.033 4 0.809
AKT2AKT2 0.841 0.075 -3 0.695
PKCHPKCH 0.840 -0.014 2 0.745
MNK1MNK1 0.840 0.021 -2 0.824
NUAK1NUAK1 0.840 -0.080 -3 0.800
PAK6PAK6 0.840 0.058 -2 0.741
MELKMELK 0.839 -0.085 -3 0.808
PKCZPKCZ 0.839 -0.033 2 0.791
P38AP38A 0.839 0.063 1 0.745
P38BP38B 0.839 0.093 1 0.677
PAK2PAK2 0.839 -0.032 -2 0.804
QIKQIK 0.839 -0.145 -3 0.834
CDK2CDK2 0.839 0.081 1 0.756
DRAK1DRAK1 0.838 -0.013 1 0.794
HIPK2HIPK2 0.838 0.105 1 0.642
ERK1ERK1 0.838 0.073 1 0.670
SGK3SGK3 0.838 0.037 -3 0.768
CK2A2CK2A2 0.838 0.207 1 0.734
PHKG1PHKG1 0.838 -0.086 -3 0.832
PIM2PIM2 0.838 0.050 -3 0.753
PASKPASK 0.838 0.104 -3 0.875
HIPK1HIPK1 0.838 0.089 1 0.744
BRSK1BRSK1 0.838 -0.056 -3 0.796
P38GP38G 0.838 0.089 1 0.598
DNAPKDNAPK 0.837 -0.026 1 0.665
SIKSIK 0.837 -0.055 -3 0.768
TLK2TLK2 0.837 -0.076 1 0.767
CDK17CDK17 0.836 0.070 1 0.603
CHAK1CHAK1 0.836 -0.154 2 0.789
CK1ECK1E 0.836 0.001 -3 0.528
ERK2ERK2 0.836 0.034 1 0.719
DCAMKL1DCAMKL1 0.836 -0.004 -3 0.793
MARK3MARK3 0.836 -0.038 4 0.772
NEK2NEK2 0.835 -0.163 2 0.820
CHK1CHK1 0.835 -0.066 -3 0.853
CDK12CDK12 0.835 0.041 1 0.667
MEKK3MEKK3 0.835 -0.096 1 0.805
MARK2MARK2 0.834 -0.059 4 0.732
MST3MST3 0.834 0.030 2 0.854
SMG1SMG1 0.834 -0.127 1 0.747
PKACAPKACA 0.834 0.100 -2 0.684
CAMK1GCAMK1G 0.834 -0.030 -3 0.761
BRAFBRAF 0.833 -0.103 -4 0.835
GAKGAK 0.833 0.163 1 0.879
DYRK4DYRK4 0.833 0.097 1 0.659
DYRK1ADYRK1A 0.832 0.043 1 0.767
CDK9CDK9 0.832 0.006 1 0.702
CDK14CDK14 0.832 0.075 1 0.700
SMMLCKSMMLCK 0.832 0.016 -3 0.819
MPSK1MPSK1 0.832 0.085 1 0.804
GRK3GRK3 0.831 0.029 -2 0.676
MEKK2MEKK2 0.831 -0.094 2 0.818
ZAKZAK 0.830 -0.143 1 0.788
BRSK2BRSK2 0.830 -0.146 -3 0.815
PRP4PRP4 0.830 -0.002 -3 0.750
MEK5MEK5 0.830 -0.256 2 0.837
CDK10CDK10 0.830 0.100 1 0.685
HRIHRI 0.830 -0.198 -2 0.843
MEKK1MEKK1 0.830 -0.170 1 0.805
PLK4PLK4 0.829 -0.151 2 0.640
PERKPERK 0.829 -0.182 -2 0.831
TAO3TAO3 0.829 -0.024 1 0.801
TLK1TLK1 0.829 -0.107 -2 0.836
CK1DCK1D 0.829 0.012 -3 0.471
CK2A1CK2A1 0.828 0.194 1 0.714
MARK1MARK1 0.828 -0.090 4 0.788
PINK1PINK1 0.828 -0.176 1 0.840
AKT1AKT1 0.828 0.061 -3 0.715
SNRKSNRK 0.827 -0.239 2 0.687
DCAMKL2DCAMKL2 0.827 -0.053 -3 0.815
SSTKSSTK 0.827 -0.035 4 0.803
DYRK1BDYRK1B 0.827 0.053 1 0.694
MAPKAPK5MAPKAPK5 0.827 -0.141 -3 0.718
HIPK3HIPK3 0.827 0.024 1 0.736
CDK16CDK16 0.827 0.080 1 0.622
P38DP38D 0.826 0.087 1 0.605
NEK5NEK5 0.826 -0.159 1 0.824
PKCTPKCT 0.826 -0.034 2 0.752
WNK4WNK4 0.825 -0.198 -2 0.847
DYRK3DYRK3 0.825 0.063 1 0.735
JNK1JNK1 0.825 0.078 1 0.656
DAPK3DAPK3 0.824 0.062 -3 0.807
CK1A2CK1A2 0.824 -0.001 -3 0.469
PLK2PLK2 0.824 0.076 -3 0.835
PKCEPKCE 0.824 0.050 2 0.750
IRAK4IRAK4 0.824 -0.172 1 0.793
P70S6KP70S6K 0.824 -0.037 -3 0.714
EEF2KEEF2K 0.823 0.050 3 0.891
MAKMAK 0.823 0.150 -2 0.742
CAMK1DCAMK1D 0.823 -0.004 -3 0.692
PKCIPKCI 0.822 -0.035 2 0.761
GCKGCK 0.822 0.019 1 0.809
CK1G1CK1G1 0.822 -0.064 -3 0.531
MST2MST2 0.821 -0.030 1 0.806
DAPK1DAPK1 0.821 0.070 -3 0.786
TAO2TAO2 0.820 -0.105 2 0.863
NEK8NEK8 0.820 -0.184 2 0.828
NEK11NEK11 0.819 -0.195 1 0.798
PHKG2PHKG2 0.819 -0.103 -3 0.795
ERK7ERK7 0.819 -0.004 2 0.541
PAK4PAK4 0.819 0.024 -2 0.702
PAK5PAK5 0.819 -0.005 -2 0.693
TNIKTNIK 0.819 0.032 3 0.897
CAMKK1CAMKK1 0.818 -0.216 -2 0.733
TAK1TAK1 0.818 -0.050 1 0.820
MINKMINK 0.817 -0.034 1 0.793
HGKHGK 0.817 -0.041 3 0.894
PDK1PDK1 0.817 -0.127 1 0.793
AKT3AKT3 0.816 0.064 -3 0.636
SGK1SGK1 0.816 0.059 -3 0.621
HPK1HPK1 0.815 -0.027 1 0.791
TTBK1TTBK1 0.814 -0.239 2 0.636
PDHK3_TYRPDHK3_TYR 0.814 0.292 4 0.914
LKB1LKB1 0.814 -0.182 -3 0.827
CAMKK2CAMKK2 0.814 -0.195 -2 0.731
CDK6CDK6 0.814 0.057 1 0.678
MEKK6MEKK6 0.813 -0.161 1 0.805
MAP3K15MAP3K15 0.813 -0.137 1 0.771
IRAK1IRAK1 0.812 -0.333 -1 0.715
MRCKAMRCKA 0.812 0.026 -3 0.763
PKN1PKN1 0.812 -0.046 -3 0.726
CHK2CHK2 0.811 -0.019 -3 0.637
ROCK2ROCK2 0.811 0.037 -3 0.795
LRRK2LRRK2 0.811 -0.193 2 0.853
MRCKBMRCKB 0.811 0.025 -3 0.741
NEK4NEK4 0.810 -0.221 1 0.783
KHS2KHS2 0.810 0.032 1 0.791
MST1MST1 0.810 -0.087 1 0.786
CDK4CDK4 0.809 0.035 1 0.652
KHS1KHS1 0.809 -0.019 1 0.775
NEK1NEK1 0.808 -0.165 1 0.798
VRK1VRK1 0.808 -0.209 2 0.842
MOKMOK 0.808 0.052 1 0.746
CAMK1ACAMK1A 0.808 -0.015 -3 0.658
LOKLOK 0.807 -0.119 -2 0.762
BMPR2_TYRBMPR2_TYR 0.807 0.188 -1 0.897
SBKSBK 0.806 0.015 -3 0.578
DMPK1DMPK1 0.806 0.077 -3 0.762
PDHK4_TYRPDHK4_TYR 0.806 0.162 2 0.892
SLKSLK 0.805 -0.111 -2 0.706
BUB1BUB1 0.805 0.037 -5 0.748
MAP2K6_TYRMAP2K6_TYR 0.805 0.130 -1 0.880
PBKPBK 0.804 0.005 1 0.799
MAP2K4_TYRMAP2K4_TYR 0.803 0.041 -1 0.872
TTKTTK 0.803 0.001 -2 0.824
YSK1YSK1 0.803 -0.126 2 0.822
TESK1_TYRTESK1_TYR 0.802 -0.035 3 0.905
RIPK2RIPK2 0.801 -0.308 1 0.733
STK33STK33 0.801 -0.213 2 0.635
PDHK1_TYRPDHK1_TYR 0.801 0.056 -1 0.892
OSR1OSR1 0.801 -0.043 2 0.812
EPHA6EPHA6 0.800 0.148 -1 0.876
MEK2MEK2 0.800 -0.331 2 0.821
PKMYT1_TYRPKMYT1_TYR 0.799 -0.059 3 0.871
PKG1PKG1 0.799 -0.003 -2 0.654
ALPHAK3ALPHAK3 0.798 -0.004 -1 0.783
MAP2K7_TYRMAP2K7_TYR 0.798 -0.181 2 0.872
BIKEBIKE 0.796 0.076 1 0.771
ROCK1ROCK1 0.796 0.010 -3 0.755
CRIKCRIK 0.796 0.024 -3 0.718
HASPINHASPIN 0.796 -0.049 -1 0.643
PINK1_TYRPINK1_TYR 0.795 -0.151 1 0.847
CK1ACK1A 0.794 -0.004 -3 0.380
EPHB4EPHB4 0.794 0.060 -1 0.839
LIMK2_TYRLIMK2_TYR 0.794 -0.061 -3 0.894
TXKTXK 0.792 0.146 1 0.857
MYO3AMYO3A 0.791 -0.071 1 0.774
MYO3BMYO3B 0.791 -0.082 2 0.839
ASK1ASK1 0.790 -0.188 1 0.762
YES1YES1 0.789 0.011 -1 0.823
NEK3NEK3 0.788 -0.284 1 0.759
RETRET 0.787 -0.168 1 0.797
LCKLCK 0.787 0.111 -1 0.837
YANK3YANK3 0.787 -0.097 2 0.420
EPHA4EPHA4 0.786 0.031 2 0.788
BLKBLK 0.786 0.134 -1 0.845
LIMK1_TYRLIMK1_TYR 0.786 -0.238 2 0.864
ROS1ROS1 0.786 -0.124 3 0.805
INSRRINSRR 0.785 -0.026 3 0.782
JAK3JAK3 0.785 -0.047 1 0.788
HCKHCK 0.785 0.011 -1 0.830
TYRO3TYRO3 0.785 -0.159 3 0.827
FGRFGR 0.785 -0.058 1 0.867
TYK2TYK2 0.785 -0.219 1 0.793
MST1RMST1R 0.784 -0.188 3 0.827
DDR1DDR1 0.784 -0.170 4 0.834
CSF1RCSF1R 0.784 -0.110 3 0.811
TAO1TAO1 0.783 -0.160 1 0.724
JAK2JAK2 0.783 -0.177 1 0.794
FYNFYN 0.782 0.135 -1 0.827
FERFER 0.782 -0.113 1 0.873
ABL2ABL2 0.782 -0.062 -1 0.782
EPHB1EPHB1 0.782 -0.016 1 0.846
ITKITK 0.781 -0.006 -1 0.787
SRMSSRMS 0.781 -0.035 1 0.857
EPHB2EPHB2 0.781 0.017 -1 0.822
AAK1AAK1 0.780 0.122 1 0.675
EPHB3EPHB3 0.779 -0.034 -1 0.819
FGFR2FGFR2 0.777 -0.137 3 0.816
TNK2TNK2 0.777 -0.105 3 0.771
BMXBMX 0.777 -0.015 -1 0.713
ABL1ABL1 0.776 -0.112 -1 0.771
STLK3STLK3 0.776 -0.238 1 0.744
KITKIT 0.776 -0.129 3 0.813
KDRKDR 0.775 -0.102 3 0.777
TNNI3K_TYRTNNI3K_TYR 0.775 -0.055 1 0.801
PTK2PTK2 0.775 0.158 -1 0.862
PDGFRBPDGFRB 0.774 -0.206 3 0.827
METMET 0.773 -0.083 3 0.794
FLT1FLT1 0.773 -0.033 -1 0.853
EPHA7EPHA7 0.773 -0.021 2 0.785
TECTEC 0.773 -0.078 -1 0.707
JAK1JAK1 0.773 -0.104 1 0.739
NEK10_TYRNEK10_TYR 0.772 -0.171 1 0.699
FLT3FLT3 0.772 -0.197 3 0.816
MERTKMERTK 0.771 -0.118 3 0.785
FGFR1FGFR1 0.771 -0.199 3 0.789
LYNLYN 0.771 -0.023 3 0.739
DDR2DDR2 0.770 -0.021 3 0.768
TEKTEK 0.769 -0.215 3 0.767
SYKSYK 0.769 0.126 -1 0.831
EPHA3EPHA3 0.769 -0.104 2 0.759
AXLAXL 0.769 -0.200 3 0.794
BTKBTK 0.768 -0.206 -1 0.731
FGFR3FGFR3 0.768 -0.125 3 0.792
SRCSRC 0.768 -0.008 -1 0.804
FRKFRK 0.768 -0.085 -1 0.833
ERBB2ERBB2 0.768 -0.157 1 0.765
EPHA5EPHA5 0.767 -0.009 2 0.772
WEE1_TYRWEE1_TYR 0.767 -0.143 -1 0.712
TNK1TNK1 0.767 -0.219 3 0.799
INSRINSR 0.767 -0.148 3 0.760
CK1G3CK1G3 0.766 -0.043 -3 0.330
ALKALK 0.766 -0.196 3 0.745
NTRK1NTRK1 0.766 -0.218 -1 0.798
EPHA8EPHA8 0.765 -0.029 -1 0.816
PDGFRAPDGFRA 0.764 -0.314 3 0.825
EGFREGFR 0.763 -0.058 1 0.681
LTKLTK 0.763 -0.203 3 0.760
PTK2BPTK2B 0.763 -0.080 -1 0.736
FLT4FLT4 0.762 -0.197 3 0.773
EPHA1EPHA1 0.762 -0.164 3 0.771
NTRK2NTRK2 0.762 -0.242 3 0.777
PTK6PTK6 0.761 -0.284 -1 0.684
NTRK3NTRK3 0.761 -0.166 -1 0.749
MATKMATK 0.758 -0.163 -1 0.704
EPHA2EPHA2 0.758 -0.004 -1 0.796
FGFR4FGFR4 0.757 -0.104 -1 0.765
CSKCSK 0.755 -0.181 2 0.788
ERBB4ERBB4 0.755 -0.019 1 0.704
CK1G2CK1G2 0.754 -0.017 -3 0.435
YANK2YANK2 0.753 -0.132 2 0.440
IGF1RIGF1R 0.753 -0.128 3 0.700
MUSKMUSK 0.743 -0.221 1 0.668
ZAP70ZAP70 0.739 -0.029 -1 0.740
FESFES 0.736 -0.170 -1 0.680