Motif 15 (n=180)

Position-wise Probabilities

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uniprot genes site source protein function
A1L170 C1orf226 S223 ochoa Uncharacterized protein C1orf226 None
B8ZZF3 None S186 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
O00429 DNM1L S126 ochoa Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.
O14523 C2CD2L S464 ochoa Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}.
O14647 CHD2 S1365 ochoa Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.
O14686 KMT2D S4883 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14936 CASK S395 ochoa Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}.
O15018 PDZD2 S1988 ochoa PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] None
O15360 FANCA S1377 ochoa Fanconi anemia group A protein (Protein FACA) DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
O43704 SULT1B1 S92 ochoa Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). {ECO:0000269|PubMed:28084139, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.
O60711 LPXN S188 ochoa Leupaxin Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
O94885 SASH1 S297 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94906 PRPF6 S279 ochoa Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}.
O95292 VAPB S206 ochoa Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}.
O95402 MED26 S178 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
P00918 CA2 S29 ochoa Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}.
P10914 IRF1 S215 psp Interferon regulatory factor 1 (IRF-1) Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essentail role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}.
P13639 EEF2 S502 ochoa Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P13639 EEF2 S595 ochoa|psp Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P13995 MTHFD2 S149 ochoa Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. {ECO:0000269|PubMed:16100107}.
P14866 HNRNPL S291 ochoa Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
P17028 ZNF24 S63 ochoa Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}.
P23508 MCC S294 ochoa Colorectal mutant cancer protein (Protein MCC) Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}.
P24864 CCNE1 S103 ochoa|psp G1/S-specific cyclin-E1 Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
P32189 GK S125 ochoa Glycerol kinase (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis. {ECO:0000269|PubMed:15845384, ECO:0000269|PubMed:37021775}.
P33240 CSTF2 S154 ochoa Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}.
P35606 COPB2 S859 ochoa|psp Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
P42575 CASP2 S340 ochoa|psp Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}.
P43007 SLC1A4 S507 ochoa Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}.
P46013 MKI67 S1131 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S1253 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S1983 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S2223 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S2344 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S2466 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46019 PHKA2 S735 ochoa Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P46020 PHKA1 S735 ochoa Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P46100 ATRX S1996 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46821 MAP1B S1965 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P50570 DNM2 S116 ochoa Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}.
P51149 RAB7A S111 ochoa Ras-related protein Rab-7a (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}.
P51948 MNAT1 S279 ochoa CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.
P78332 RBM6 S1025 ochoa RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) Specifically binds poly(G) RNA homopolymers in vitro.
P78395 PRAME S277 ochoa Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma) Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254). {ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}.
P81274 GPSM2 S541 ochoa G-protein-signaling modulator 2 (Mosaic protein LGN) Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}.
P84157 MXRA7 S144 ochoa Matrix-remodeling-associated protein 7 None
Q01860 POU5F1 S111 psp POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}.
Q01974 ROR2 S569 ochoa Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.
Q03001 DST S2215 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03164 KMT2A S3053 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q06413 MEF2C S240 ochoa Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.
Q06546 GABPA S309 ochoa GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene.
Q06945 SOX4 S81 ochoa Transcription factor SOX-4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}.
Q08J23 NSUN2 S473 ochoa RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}.
Q12770 SCAP S907 ochoa Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}.
Q13263 TRIM28 S757 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13323 BIK S124 psp Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.
Q13469 NFATC2 S110 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q14004 CDK13 S525 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14139 UBE4A S551 ochoa Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}.
Q14155 ARHGEF7 S518 ochoa|psp Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
Q14409 GK3 S125 ochoa Glycerol kinase 3 (GK 3) (Glycerokinase 3) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 3) (Glycerol kinase 3 pseudogene) (Glycerol kinase, testis specific 1) May be involved in the regulation of glycerol uptake and metabolism. {ECO:0000305}.
Q14789 GOLGB1 S3016 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14CS0 UBXN2B S56 ochoa|psp UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}.
Q15052 ARHGEF6 S488 ochoa|psp Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Q15345 LRRC41 S155 ochoa Leucine-rich repeat-containing protein 41 (Protein Muf1) Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.
Q15468 STIL S1111 ochoa SCL-interrupting locus protein (TAL-1-interrupting locus protein) Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}.
Q15652 JMJD1C S1185 ochoa Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.
Q16828 DUSP6 S331 ochoa Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}.
Q16829 DUSP7 S369 ochoa Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). {ECO:0000250|UniProtKB:Q91Z46, ECO:0000269|PubMed:9788880}.
Q1AE95 TMEM183BP S336 ochoa Putative transmembrane protein 183BP (Transmembrane protein 183B pseudogene) None
Q4KWH8 PLCH1 S1386 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.
Q562F6 SGO2 S1144 ochoa Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}.
Q56NI9 ESCO2 S29 ochoa N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}.
Q5T4S7 UBR4 S660 ochoa E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}.
Q5T8I9 HENMT1 S329 ochoa Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}.
Q5T8P6 RBM26 S518 ochoa RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}.
Q5U623 ATF7IP2 S488 ochoa Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}.
Q5UIP0 RIF1 S782 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VUA4 ZNF318 S2091 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q5VV67 PPRC1 S771 ochoa Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}.
Q5VVJ2 MYSM1 S110 ochoa Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}.
Q5VZ89 DENND4C S741 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q69YH5 CDCA2 S437 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6MZQ0 PRR5L S29 ochoa Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.
Q6S5L8 SHC4 S132 ochoa|psp SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Q6TFL4 KLHL24 S19 ochoa Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062, ECO:0000269|PubMed:30715372}.
Q6UB99 ANKRD11 S860 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6VY07 PACS1 S534 ochoa Phosphofurin acidic cluster sorting protein 1 (PACS-1) Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.
Q6XR72 SLC30A10 S402 ochoa Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10) Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129). {ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481}.
Q6ZWE6 PLEKHM3 S350 ochoa Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}.
Q70CQ3 USP30 S210 ochoa Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.
Q71F56 MED13L S826 ochoa Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Q7L7X3 TAOK1 S177 ochoa Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}.
Q7Z333 SETX S1330 ochoa Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}.
Q7Z4H7 HAUS6 S507 ochoa HAUS augmin-like complex subunit 6 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Q7Z589 EMSY S1136 ochoa BRCA2-interacting transcriptional repressor EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
Q7Z698 SPRED2 S104 ochoa Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}.
Q7Z6G8 ANKS1B S310 ochoa Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Q7Z6Z7 HUWE1 S3127 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q7Z6Z7 HUWE1 S3373 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86SQ0 PHLDB2 S909 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86TC9 MYPN S386 ochoa Myopalladin (145 kDa sarcomeric protein) Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.
Q86TU7 SETD3 S38 ochoa Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.
Q86YA3 ZGRF1 S880 ochoa 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219). {ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:34552057}.
Q8IUF8 RIOX2 S47 ochoa Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.
Q8IX01 SUGP2 S773 ochoa SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) May play a role in mRNA splicing. {ECO:0000305}.
Q8IXX5 TMEM183A S336 ochoa Transmembrane protein 183A None
Q8IYH5 ZZZ3 S606 ochoa ZZ-type zinc finger-containing protein 3 Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}.
Q8IZ21 PHACTR4 S427 ochoa Phosphatase and actin regulator 4 Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZ73 RPUSD2 S436 ochoa Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}.
Q8N4X5 AFAP1L2 S213 ochoa Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.
Q8N883 ZNF614 S92 ochoa Zinc finger protein 614 May be involved in transcriptional regulation.
Q8NCF5 NFATC2IP S234 ochoa NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
Q8NI77 KIF18A S674 ochoa Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}.
Q8TEQ6 GEMIN5 S1267 ochoa Gem-associated protein 5 (Gemin5) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.
Q8WY36 BBX S844 ochoa HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.
Q8WYP5 AHCTF1 S1283 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92539 LPIN2 S229 ochoa Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}.
Q92576 PHF3 S1184 ochoa PHD finger protein 3 None
Q92817 EVPL S1698 ochoa Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
Q96CU9 FOXRED1 S189 ochoa FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.
Q96DA6 DNAJC19 S70 ochoa Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19) Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}.
Q96E22 NUS1 S168 ochoa Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466, ECO:0000269|PubMed:33077723}.
Q96FI4 NEIL1 S207 ochoa|psp Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
Q96GX5 MASTL S370 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96HA1 POM121 S108 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96HH9 GRAMD2B S225 ochoa GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) None
Q96JH7 VCPIP1 S131 ochoa Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}.
Q96RU2 USP28 S279 ochoa Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}.
Q96RY5 CRAMP1 S533 ochoa Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) None
Q99728 BARD1 S496 ochoa BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}.
Q99956 DUSP9 S328 ochoa Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) Inactivates MAP kinases. Has a specificity for the ERK family.
Q9BPX5 ARPC5L S64 ochoa Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Q9BQE4 SELENOS S140 ochoa Selenoprotein S (SelS) (VCP-interacting membrane protein) Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.
Q9BV36 MLPH S444 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BW91 NUDT9 S121 ochoa ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}.
Q9BX63 BRIP1 S956 ochoa Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}.
Q9BX66 SORBS1 S556 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXC9 BBS2 S365 ochoa BBSome complex member BBS2 (Bardet-Biedl syndrome 2 protein) The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Q9BYW2 SETD2 S131 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9C0B5 ZDHHC5 S247 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9H270 VPS11 S813 ochoa Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). {ECO:0000269|PubMed:21148287, ECO:0000269|PubMed:23593995, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24554770, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}.
Q9H2D6 TRIOBP S1796 ochoa TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.
Q9H2F5 EPC1 S427 ochoa Enhancer of polycomb homolog 1 Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.
Q9H2K8 TAOK3 S173 ochoa Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}.
Q9H2T7 RANBP17 S296 ochoa Ran-binding protein 17 May function as a nuclear transport receptor. {ECO:0000250}.
Q9H501 ESF1 S198 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H972 C14orf93 S285 ochoa Uncharacterized protein C14orf93 None
Q9HAU0 PLEKHA5 S607 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9NS56 TOPORS S194 ochoa E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}.
Q9NUQ2 AGPAT5 S298 ochoa 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). {ECO:0000269|PubMed:21173190}.
Q9NVS9 PNPO S241 ochoa Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}.
Q9NX95 SYBU S396 ochoa Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
Q9NY74 ETAA1 S95 ochoa|psp Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}.
Q9NYF8 BCLAF1 S531 ochoa|psp Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9UBU7 DBF4 S629 ochoa Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
Q9UHG0 DCDC2 S270 ochoa Doublecortin domain-containing protein 2 (Protein RU2S) Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}.
Q9UIF9 BAZ2A S613 ochoa Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}.
Q9UJF2 RASAL2 S946 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UL03 INTS6 S150 ochoa Integrator complex subunit 6 (Int6) (DBI-1) (Protein deleted in cancer 1) (DICE1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:39504960}.
Q9ULD2 MTUS1 S443 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9ULV3 CIZ1 S838 ochoa Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) May regulate the subcellular localization of CIP/WAF1.
Q9UNA4 POLI S502 ochoa DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}.
Q9UPQ4 TRIM35 S65 ochoa E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}.
Q9UPU7 TBC1D2B S155 ochoa TBC1 domain family member 2B GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}.
Q9Y210 TRPC6 S282 psp Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}.
Q9Y4C1 KDM3A S283 ochoa Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.
Q9Y673 ALG5 S62 ochoa Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) Dolichyl-phosphate beta-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Dolichyl-phosphate beta-glucosyltransferase produces dolichyl beta-D-glucosyl phosphate/Dol-P-Glc, the glucose donor substrate used sequentially by ALG6, ALG8 and ALG10 to add glucose residues on top of the Man(9)GlcNAc(2)-PP-Dol structure. These are the three last steps in the biosynthetic pathway of dolichol-linked oligosaccharides to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol. The enzyme is most probably active on the cytoplasmic side of the endoplasmic reticulum while its product Dol-P-Glc is the substrate for ALG6, ALG8 and ALG11 in the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:10359825, ECO:0000269|PubMed:35896117}.
Q9Y6K1 DNMT3A S75 ochoa DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.
Q9Y6X0 SETBP1 S611 ochoa SET-binding protein (SEB) None
Q9Y6X8 ZHX2 S719 ochoa Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}.
O00444 PLK4 S499 Sugiyama Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
Q13547 HDAC1 S88 Sugiyama Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}.
Q92769 HDAC2 S89 Sugiyama Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}.
P20020 ATP2B1 S1178 ELM|iPTMNet|EPSD Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}.
Q6EMK4 VASN S322 Sugiyama Vasorin (Protein slit-like 2) May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}.
Q13873 BMPR2 S233 Sugiyama Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}.
P50990 CCT8 S161 Sugiyama T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
Q9UQ07 MOK S365 Sugiyama MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}.
Download
reactome_id name p -log10_p
R-HSA-9652817 Signaling by MAPK mutants 0.000129 3.890
R-HSA-3247509 Chromatin modifying enzymes 0.000248 3.606
R-HSA-4839726 Chromatin organization 0.000400 3.398
R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 0.002379 2.624
R-HSA-198753 ERK/MAPK targets 0.003782 2.422
R-HSA-1640170 Cell Cycle 0.002670 2.573
R-HSA-3214841 PKMTs methylate histone lysines 0.002675 2.573
R-HSA-69278 Cell Cycle, Mitotic 0.004392 2.357
R-HSA-112409 RAF-independent MAPK1/3 activation 0.004644 2.333
R-HSA-75109 Triglyceride biosynthesis 0.007284 2.138
R-HSA-9022707 MECP2 regulates transcription factors 0.006408 2.193
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.008542 2.068
R-HSA-2025928 Calcineurin activates NFAT 0.009087 2.042
R-HSA-9616334 Defective Base Excision Repair Associated with NEIL1 0.011730 1.931
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.015665 1.805
R-HSA-427413 NoRC negatively regulates rRNA expression 0.014836 1.829
R-HSA-202670 ERKs are inactivated 0.013874 1.858
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.013906 1.857
R-HSA-9706019 RHOBTB3 ATPase cycle 0.012179 1.914
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.013054 1.884
R-HSA-69205 G1/S-Specific Transcription 0.014797 1.830
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.015462 1.811
R-HSA-193704 p75 NTR receptor-mediated signalling 0.010298 1.987
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.015720 1.804
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.023323 1.632
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.023323 1.632
R-HSA-9673013 Diseases of Telomere Maintenance 0.023323 1.632
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.023323 1.632
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.023323 1.632
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.023323 1.632
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.023323 1.632
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.016674 1.778
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.021852 1.661
R-HSA-212165 Epigenetic regulation of gene expression 0.021487 1.668
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.019525 1.709
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.021923 1.659
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.021073 1.676
R-HSA-1475029 Reversible hydration of carbon dioxide 0.017549 1.756
R-HSA-9659379 Sensory processing of sound 0.020313 1.692
R-HSA-69620 Cell Cycle Checkpoints 0.018187 1.740
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.021589 1.666
R-HSA-5675221 Negative regulation of MAPK pathway 0.020809 1.682
R-HSA-6802957 Oncogenic MAPK signaling 0.025139 1.600
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.026005 1.585
R-HSA-141424 Amplification of signal from the kinetochores 0.026005 1.585
R-HSA-69206 G1/S Transition 0.026046 1.584
R-HSA-9675135 Diseases of DNA repair 0.026698 1.574
R-HSA-9675151 Disorders of Developmental Biology 0.025973 1.585
R-HSA-9827857 Specification of primordial germ cells 0.028289 1.548
R-HSA-8986944 Transcriptional Regulation by MECP2 0.031575 1.501
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.033158 1.479
R-HSA-9754189 Germ layer formation at gastrulation 0.033158 1.479
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.035706 1.447
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.035706 1.447
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.035706 1.447
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.035706 1.447
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.035706 1.447
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.040859 1.389
R-HSA-4755609 Defective DHDDS causes RP59 0.046105 1.336
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.057297 1.242
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.057297 1.242
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.052462 1.280
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.047393 1.324
R-HSA-69618 Mitotic Spindle Checkpoint 0.043478 1.362
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.057297 1.242
R-HSA-350054 Notch-HLH transcription pathway 0.043781 1.359
R-HSA-9842860 Regulation of endogenous retroelements 0.045879 1.338
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.055480 1.256
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.046091 1.336
R-HSA-1852241 Organelle biogenesis and maintenance 0.049923 1.302
R-HSA-376172 DSCAM interactions 0.046105 1.336
R-HSA-5689901 Metalloprotease DUBs 0.055480 1.256
R-HSA-68877 Mitotic Prometaphase 0.041009 1.387
R-HSA-3214842 HDMs demethylate histones 0.052462 1.280
R-HSA-68886 M Phase 0.050983 1.293
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.056206 1.250
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.052462 1.280
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.055480 1.256
R-HSA-8979227 Triglyceride metabolism 0.045714 1.340
R-HSA-450294 MAP kinase activation 0.049102 1.309
R-HSA-73887 Death Receptor Signaling 0.054365 1.265
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.061890 1.208
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.064887 1.188
R-HSA-418360 Platelet calcium homeostasis 0.064887 1.188
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.068359 1.165
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.081630 1.088
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.065802 1.182
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.078183 1.107
R-HSA-5693537 Resolution of D-Loop Structures 0.081630 1.088
R-HSA-9675126 Diseases of mitotic cell cycle 0.074783 1.126
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.078183 1.107
R-HSA-1538133 G0 and Early G1 0.074783 1.126
R-HSA-9636569 Suppression of autophagy 0.079291 1.101
R-HSA-1592230 Mitochondrial biogenesis 0.070725 1.150
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.078193 1.107
R-HSA-205025 NADE modulates death signalling 0.068359 1.165
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.077021 1.113
R-HSA-9733709 Cardiogenesis 0.078183 1.107
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.081267 1.090
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.071877 1.143
R-HSA-9022692 Regulation of MECP2 expression and activity 0.078183 1.107
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.078183 1.107
R-HSA-448424 Interleukin-17 signaling 0.065802 1.182
R-HSA-73864 RNA Polymerase I Transcription 0.082535 1.083
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.085123 1.070
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.085123 1.070
R-HSA-8849470 PTK6 Regulates Cell Cycle 0.090096 1.045
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.100774 0.997
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.111328 0.953
R-HSA-418886 Netrin mediated repulsion signals 0.111328 0.953
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 0.132067 0.879
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.142256 0.847
R-HSA-390450 Folding of actin by CCT/TriC 0.142256 0.847
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.162277 0.790
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.162277 0.790
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.181834 0.740
R-HSA-418885 DCC mediated attractive signaling 0.200936 0.697
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.210320 0.677
R-HSA-5656121 Translesion synthesis by POLI 0.210320 0.677
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.219595 0.658
R-HSA-8964616 G beta:gamma signalling through CDC42 0.219595 0.658
R-HSA-5658442 Regulation of RAS by GAPs 0.150184 0.823
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.289993 0.538
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.289993 0.538
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.298337 0.525
R-HSA-191859 snRNP Assembly 0.187653 0.727
R-HSA-194441 Metabolism of non-coding RNA 0.187653 0.727
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.204700 0.689
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.204700 0.689
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.346388 0.460
R-HSA-8854518 AURKA Activation by TPX2 0.217594 0.662
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.247916 0.606
R-HSA-380287 Centrosome maturation 0.256614 0.591
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.317388 0.498
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.314732 0.502
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.326003 0.487
R-HSA-72086 mRNA Capping 0.338613 0.470
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.219595 0.658
R-HSA-390466 Chaperonin-mediated protein folding 0.313072 0.504
R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.111328 0.953
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.121759 0.915
R-HSA-190873 Gap junction degradation 0.132067 0.879
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.132067 0.879
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.219595 0.658
R-HSA-73863 RNA Polymerase I Transcription Termination 0.322786 0.491
R-HSA-5693607 Processing of DNA double-strand break ends 0.282720 0.549
R-HSA-69202 Cyclin E associated events during G1/S transition 0.234891 0.629
R-HSA-373752 Netrin-1 signaling 0.126175 0.899
R-HSA-68962 Activation of the pre-replicative complex 0.346388 0.460
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.314732 0.502
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.331331 0.480
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.221909 0.654
R-HSA-391251 Protein folding 0.338871 0.470
R-HSA-446107 Type I hemidesmosome assembly 0.121759 0.915
R-HSA-196025 Formation of annular gap junctions 0.121759 0.915
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.142256 0.847
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.152325 0.817
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.181834 0.740
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.237820 0.624
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.106968 0.971
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.289993 0.538
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.230558 0.637
R-HSA-201451 Signaling by BMP 0.322786 0.491
R-HSA-3928664 Ephrin signaling 0.237820 0.624
R-HSA-9843745 Adipogenesis 0.097518 1.011
R-HSA-5656169 Termination of translesion DNA synthesis 0.338613 0.470
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.285763 0.544
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.162508 0.789
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO 0.132067 0.879
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.099528 1.002
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.281551 0.550
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.298337 0.525
R-HSA-3214815 HDACs deacetylate histones 0.170823 0.767
R-HSA-2980766 Nuclear Envelope Breakdown 0.179207 0.747
R-HSA-5693532 DNA Double-Strand Break Repair 0.328120 0.484
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.243571 0.613
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.106968 0.971
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.106968 0.971
R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 0.100774 0.997
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.132067 0.879
R-HSA-418359 Reduction of cytosolic Ca++ levels 0.162277 0.790
R-HSA-177504 Retrograde neurotrophin signalling 0.191441 0.718
R-HSA-964975 Vitamin B6 activation to pyridoxal phosphate 0.219595 0.658
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.237820 0.624
R-HSA-113418 Formation of the Early Elongation Complex 0.330746 0.481
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.346388 0.460
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.295752 0.529
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.295752 0.529
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.142079 0.847
R-HSA-4641265 Repression of WNT target genes 0.172113 0.764
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.088661 1.052
R-HSA-6784531 tRNA processing in the nucleus 0.200421 0.698
R-HSA-5334118 DNA methylation 0.338613 0.470
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.239229 0.621
R-HSA-73894 DNA Repair 0.164535 0.784
R-HSA-9834899 Specification of the neural plate border 0.246773 0.608
R-HSA-9605308 Diseases of Base Excision Repair 0.090096 1.045
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.243571 0.613
R-HSA-5617833 Cilium Assembly 0.234435 0.630
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.142256 0.847
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.246773 0.608
R-HSA-69473 G2/M DNA damage checkpoint 0.252264 0.598
R-HSA-2467813 Separation of Sister Chromatids 0.169472 0.771
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.269669 0.569
R-HSA-68875 Mitotic Prophase 0.211309 0.675
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.183423 0.737
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.217594 0.662
R-HSA-8878171 Transcriptional regulation by RUNX1 0.167260 0.777
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.246773 0.608
R-HSA-69481 G2/M Checkpoints 0.235934 0.627
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.090096 1.045
R-HSA-5336415 Uptake and function of diphtheria toxin 0.111328 0.953
R-HSA-9754560 SARS-CoV-2 modulates autophagy 0.152325 0.817
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.172113 0.764
R-HSA-9005895 Pervasive developmental disorders 0.172113 0.764
R-HSA-9697154 Disorders of Nervous System Development 0.172113 0.764
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.228761 0.641
R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.228761 0.641
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.306582 0.513
R-HSA-8943724 Regulation of PTEN gene transcription 0.191896 0.717
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.330746 0.481
R-HSA-2132295 MHC class II antigen presentation 0.220478 0.657
R-HSA-68882 Mitotic Anaphase 0.148534 0.828
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.150365 0.823
R-HSA-69242 S Phase 0.312070 0.506
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.239229 0.621
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.172113 0.764
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.278371 0.555
R-HSA-9664873 Pexophagy 0.142256 0.847
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.181834 0.740
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.289993 0.538
R-HSA-193648 NRAGE signals death through JNK 0.175007 0.757
R-HSA-525793 Myogenesis 0.314732 0.502
R-HSA-3295583 TRP channels 0.314732 0.502
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.264366 0.578
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.234891 0.629
R-HSA-446199 Synthesis of dolichyl-phosphate 0.298337 0.525
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.210320 0.677
R-HSA-69236 G1 Phase 0.126175 0.899
R-HSA-69231 Cyclin D associated events in G1 0.126175 0.899
R-HSA-8876725 Protein methylation 0.200936 0.697
R-HSA-1483213 Synthesis of PE 0.322786 0.491
R-HSA-446353 Cell-extracellular matrix interactions 0.200936 0.697
R-HSA-9629569 Protein hydroxylation 0.255621 0.592
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.273009 0.564
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.308749 0.510
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.304421 0.517
R-HSA-9636383 Prevention of phagosomal-lysosomal fusion 0.264366 0.578
R-HSA-877300 Interferon gamma signaling 0.158224 0.801
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.255621 0.592
R-HSA-5620971 Pyroptosis 0.330746 0.481
R-HSA-5673001 RAF/MAP kinase cascade 0.301692 0.520
R-HSA-8982491 Glycogen metabolism 0.106968 0.971
R-HSA-5688426 Deubiquitination 0.226217 0.645
R-HSA-373753 Nephrin family interactions 0.255621 0.592
R-HSA-9833110 RSV-host interactions 0.158441 0.800
R-HSA-5684996 MAPK1/MAPK3 signaling 0.317759 0.498
R-HSA-9823739 Formation of the anterior neural plate 0.200936 0.697
R-HSA-3000170 Syndecan interactions 0.289993 0.538
R-HSA-416482 G alpha (12/13) signalling events 0.269669 0.569
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.210320 0.677
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.114552 0.941
R-HSA-9637687 Suppression of phagosomal maturation 0.314732 0.502
R-HSA-913531 Interferon Signaling 0.342668 0.465
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.146120 0.835
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.191896 0.717
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.191896 0.717
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.191896 0.717
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.191896 0.717
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.191896 0.717
R-HSA-1500931 Cell-Cell communication 0.207637 0.683
R-HSA-446728 Cell junction organization 0.276736 0.558
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.090424 1.044
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.308749 0.510
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.234891 0.629
R-HSA-3700989 Transcriptional Regulation by TP53 0.217760 0.662
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.169820 0.770
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.139141 0.857
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.139141 0.857
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.139141 0.857
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.172701 0.763
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.134535 0.871
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.175597 0.755
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.208271 0.681
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.191896 0.717
R-HSA-166166 MyD88-independent TLR4 cascade 0.175597 0.755
R-HSA-1980143 Signaling by NOTCH1 0.260965 0.583
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.208271 0.681
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.217412 0.663
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.161263 0.792
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.217412 0.663
R-HSA-166520 Signaling by NTRKs 0.134535 0.871
R-HSA-201556 Signaling by ALK 0.103229 0.986
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.184363 0.734
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.193243 0.714
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.333905 0.476
R-HSA-5633007 Regulation of TP53 Activity 0.160451 0.795
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.273711 0.563
R-HSA-168898 Toll-like Receptor Cascades 0.236954 0.625
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.354072 0.451
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.354072 0.451
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.354072 0.451
R-HSA-182971 EGFR downregulation 0.354072 0.451
R-HSA-6807878 COPI-mediated anterograde transport 0.360146 0.444
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.360146 0.444
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.360146 0.444
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.360146 0.444
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.361666 0.442
R-HSA-1855170 IPs transport between nucleus and cytosol 0.369171 0.433
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.369171 0.433
R-HSA-397795 G-protein beta:gamma signalling 0.369171 0.433
R-HSA-176187 Activation of ATR in response to replication stress 0.369171 0.433
R-HSA-9930044 Nuclear RNA decay 0.369171 0.433
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.369171 0.433
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 0.369171 0.433
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.369171 0.433
R-HSA-3214847 HATs acetylate histones 0.372792 0.429
R-HSA-9614085 FOXO-mediated transcription 0.372792 0.429
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.376589 0.424
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.376589 0.424
R-HSA-114508 Effects of PIP2 hydrolysis 0.376589 0.424
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.376589 0.424
R-HSA-5223345 Miscellaneous transport and binding events 0.376589 0.424
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.383920 0.416
R-HSA-180746 Nuclear import of Rev protein 0.383920 0.416
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.383920 0.416
R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 0.383920 0.416
R-HSA-168638 NOD1/2 Signaling Pathway 0.383920 0.416
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.385337 0.414
R-HSA-72306 tRNA processing 0.385686 0.414
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.391165 0.408
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.395192 0.403
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.395192 0.403
R-HSA-212300 PRC2 methylates histones and DNA 0.398325 0.400
R-HSA-432720 Lysosome Vesicle Biogenesis 0.398325 0.400
R-HSA-9682385 FLT3 signaling in disease 0.398325 0.400
R-HSA-74160 Gene expression (Transcription) 0.400908 0.397
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.405401 0.392
R-HSA-5689896 Ovarian tumor domain proteases 0.405401 0.392
R-HSA-196757 Metabolism of folate and pterines 0.405401 0.392
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.405401 0.392
R-HSA-418346 Platelet homeostasis 0.406000 0.391
R-HSA-211000 Gene Silencing by RNA 0.410094 0.387
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.412395 0.385
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.412395 0.385
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.419307 0.377
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.419307 0.377
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.419307 0.377
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.419307 0.377
R-HSA-8953750 Transcriptional Regulation by E2F6 0.419307 0.377
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.426138 0.370
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.426138 0.370
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.426138 0.370
R-HSA-177243 Interactions of Rev with host cellular proteins 0.426138 0.370
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.426138 0.370
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.426138 0.370
R-HSA-167169 HIV Transcription Elongation 0.426138 0.370
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.426138 0.370
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.426138 0.370
R-HSA-201681 TCF dependent signaling in response to WNT 0.426583 0.370
R-HSA-1483249 Inositol phosphate metabolism 0.430349 0.366
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.432889 0.364
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.432889 0.364
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.432889 0.364
R-HSA-9694548 Maturation of spike protein 0.432889 0.364
R-HSA-69275 G2/M Transition 0.435894 0.361
R-HSA-5683057 MAPK family signaling cascades 0.436133 0.360
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.438349 0.358
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.439561 0.357
R-HSA-167161 HIV Transcription Initiation 0.439561 0.357
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.439561 0.357
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.439561 0.357
R-HSA-453274 Mitotic G2-G2/M phases 0.442071 0.355
R-HSA-73928 Depyrimidination 0.446155 0.351
R-HSA-110329 Cleavage of the damaged pyrimidine 0.446155 0.351
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.446504 0.350
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.450233 0.347
R-HSA-909733 Interferon alpha/beta signaling 0.450233 0.347
R-HSA-73776 RNA Polymerase II Promoter Escape 0.452672 0.344
R-HSA-9710421 Defective pyroptosis 0.452672 0.344
R-HSA-8854214 TBC/RABGAPs 0.452672 0.344
R-HSA-9637690 Response of Mtb to phagocytosis 0.452672 0.344
R-HSA-9007101 Rab regulation of trafficking 0.458078 0.339
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.459112 0.338
R-HSA-190828 Gap junction trafficking 0.459112 0.338
R-HSA-3214858 RMTs methylate histone arginines 0.459112 0.338
R-HSA-5693538 Homology Directed Repair 0.461976 0.335
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.465477 0.332
R-HSA-6783310 Fanconi Anemia Pathway 0.465477 0.332
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.465477 0.332
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.465477 0.332
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.466508 0.331
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.470441 0.327
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.471768 0.326
R-HSA-72165 mRNA Splicing - Minor Pathway 0.471768 0.326
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.471768 0.326
R-HSA-75153 Apoptotic execution phase 0.471768 0.326
R-HSA-437239 Recycling pathway of L1 0.477985 0.321
R-HSA-1483191 Synthesis of PC 0.477985 0.321
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.484129 0.315
R-HSA-425410 Metal ion SLC transporters 0.484129 0.315
R-HSA-9031628 NGF-stimulated transcription 0.484129 0.315
R-HSA-162909 Host Interactions of HIV factors 0.485016 0.314
R-HSA-73893 DNA Damage Bypass 0.490201 0.310
R-HSA-157858 Gap junction trafficking and regulation 0.490201 0.310
R-HSA-9766229 Degradation of CDH1 0.490201 0.310
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.490201 0.310
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.490201 0.310
R-HSA-6798695 Neutrophil degranulation 0.496532 0.304
R-HSA-156584 Cytosolic sulfonation of small molecules 0.502133 0.299
R-HSA-73772 RNA Polymerase I Promoter Escape 0.507994 0.294
R-HSA-72187 mRNA 3'-end processing 0.507994 0.294
R-HSA-112382 Formation of RNA Pol II elongation complex 0.507994 0.294
R-HSA-6794361 Neurexins and neuroligins 0.507994 0.294
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.507994 0.294
R-HSA-5339562 Uptake and actions of bacterial toxins 0.507994 0.294
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.513787 0.289
R-HSA-445355 Smooth Muscle Contraction 0.513787 0.289
R-HSA-1474165 Reproduction 0.514772 0.288
R-HSA-597592 Post-translational protein modification 0.517978 0.286
R-HSA-195721 Signaling by WNT 0.518216 0.285
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.518411 0.285
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.519468 0.284
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.519512 0.284
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.519512 0.284
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.519512 0.284
R-HSA-8856688 Golgi-to-ER retrograde transport 0.522032 0.282
R-HSA-9909396 Circadian clock 0.522032 0.282
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.530761 0.275
R-HSA-177929 Signaling by EGFR 0.530761 0.275
R-HSA-5578775 Ion homeostasis 0.530761 0.275
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.530761 0.275
R-HSA-5654736 Signaling by FGFR1 0.530761 0.275
R-HSA-418990 Adherens junctions interactions 0.533924 0.273
R-HSA-1483166 Synthesis of PA 0.536287 0.271
R-HSA-9764561 Regulation of CDH1 Function 0.536287 0.271
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.536287 0.271
R-HSA-6782135 Dual incision in TC-NER 0.541749 0.266
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.541749 0.266
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.547146 0.262
R-HSA-352230 Amino acid transport across the plasma membrane 0.547146 0.262
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.547146 0.262
R-HSA-6807070 PTEN Regulation 0.550344 0.259
R-HSA-8873719 RAB geranylgeranylation 0.552480 0.258
R-HSA-983189 Kinesins 0.552480 0.258
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.552480 0.258
R-HSA-73857 RNA Polymerase II Transcription 0.556689 0.254
R-HSA-73856 RNA Polymerase II Transcription Termination 0.557751 0.254
R-HSA-168325 Viral Messenger RNA Synthesis 0.557751 0.254
R-HSA-162906 HIV Infection 0.558981 0.253
R-HSA-9705683 SARS-CoV-2-host interactions 0.561716 0.250
R-HSA-1268020 Mitochondrial protein import 0.562961 0.250
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.562961 0.250
R-HSA-9707616 Heme signaling 0.562961 0.250
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.562961 0.250
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.562961 0.250
R-HSA-162599 Late Phase of HIV Life Cycle 0.564054 0.249
R-HSA-6799198 Complex I biogenesis 0.568110 0.246
R-HSA-8848021 Signaling by PTK6 0.568110 0.246
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.568110 0.246
R-HSA-69615 G1/S DNA Damage Checkpoints 0.568110 0.246
R-HSA-936837 Ion transport by P-type ATPases 0.573198 0.242
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.573198 0.242
R-HSA-199977 ER to Golgi Anterograde Transport 0.580770 0.236
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.583197 0.234
R-HSA-9758941 Gastrulation 0.587324 0.231
R-HSA-5693606 DNA Double Strand Break Response 0.588109 0.231
R-HSA-9958863 SLC-mediated transport of amino acids 0.588109 0.231
R-HSA-212436 Generic Transcription Pathway 0.590113 0.229
R-HSA-9856651 MITF-M-dependent gene expression 0.590572 0.229
R-HSA-9679191 Potential therapeutics for SARS 0.590572 0.229
R-HSA-167172 Transcription of the HIV genome 0.592963 0.227
R-HSA-5218859 Regulated Necrosis 0.592963 0.227
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.597012 0.224
R-HSA-69306 DNA Replication 0.600204 0.222
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.602500 0.220
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.603377 0.219
R-HSA-1989781 PPARA activates gene expression 0.606531 0.217
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.607186 0.217
R-HSA-1280218 Adaptive Immune System 0.609819 0.215
R-HSA-5578749 Transcriptional regulation by small RNAs 0.611816 0.213
R-HSA-74259 Purine catabolism 0.611816 0.213
R-HSA-162587 HIV Life Cycle 0.612782 0.213
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.612782 0.213
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.612782 0.213
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.615879 0.211
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.616392 0.210
R-HSA-69052 Switching of origins to a post-replicative state 0.616392 0.210
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.620914 0.207
R-HSA-421270 Cell-cell junction organization 0.621706 0.206
R-HSA-9006936 Signaling by TGFB family members 0.622016 0.206
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.625384 0.204
R-HSA-8852135 Protein ubiquitination 0.625384 0.204
R-HSA-1169408 ISG15 antiviral mechanism 0.625384 0.204
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.625384 0.204
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.625384 0.204
R-HSA-5689603 UCH proteinases 0.629801 0.201
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.634166 0.198
R-HSA-9694635 Translation of Structural Proteins 0.634166 0.198
R-HSA-9694516 SARS-CoV-2 Infection 0.635226 0.197
R-HSA-4086400 PCP/CE pathway 0.638480 0.195
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.642743 0.192
R-HSA-9833482 PKR-mediated signaling 0.646956 0.189
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.655235 0.184
R-HSA-5621481 C-type lectin receptors (CLRs) 0.657263 0.182
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.660079 0.180
R-HSA-5689880 Ub-specific processing proteases 0.662877 0.179
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.663321 0.178
R-HSA-6794362 Protein-protein interactions at synapses 0.667293 0.176
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.675097 0.171
R-HSA-9679506 SARS-CoV Infections 0.676942 0.169
R-HSA-438064 Post NMDA receptor activation events 0.678931 0.168
R-HSA-156902 Peptide chain elongation 0.682719 0.166
R-HSA-9663891 Selective autophagy 0.682719 0.166
R-HSA-9645723 Diseases of programmed cell death 0.682719 0.166
R-HSA-73884 Base Excision Repair 0.690164 0.161
R-HSA-112310 Neurotransmitter release cycle 0.690164 0.161
R-HSA-156842 Eukaryotic Translation Elongation 0.701006 0.154
R-HSA-2682334 EPH-Ephrin signaling 0.701006 0.154
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.701006 0.154
R-HSA-983712 Ion channel transport 0.705166 0.152
R-HSA-1474290 Collagen formation 0.708023 0.150
R-HSA-9824446 Viral Infection Pathways 0.708492 0.150
R-HSA-72163 mRNA Splicing - Major Pathway 0.717449 0.144
R-HSA-5389840 Mitochondrial translation elongation 0.718243 0.144
R-HSA-1483257 Phospholipid metabolism 0.720227 0.143
R-HSA-157579 Telomere Maintenance 0.721570 0.142
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.721570 0.142
R-HSA-9609690 HCMV Early Events 0.722241 0.141
R-HSA-5368286 Mitochondrial translation initiation 0.724858 0.140
R-HSA-190236 Signaling by FGFR 0.724858 0.140
R-HSA-70171 Glycolysis 0.731319 0.136
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.731621 0.136
R-HSA-389948 Co-inhibition by PD-1 0.731621 0.136
R-HSA-948021 Transport to the Golgi and subsequent modification 0.736210 0.133
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.737628 0.132
R-HSA-1483255 PI Metabolism 0.737628 0.132
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.738479 0.132
R-HSA-1483206 Glycerophospholipid biosynthesis 0.738479 0.132
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.740727 0.130
R-HSA-72172 mRNA Splicing 0.742968 0.129
R-HSA-5357801 Programmed Cell Death 0.745188 0.128
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.746817 0.127
R-HSA-5619507 Activation of HOX genes during differentiation 0.746817 0.127
R-HSA-5696398 Nucleotide Excision Repair 0.749808 0.125
R-HSA-69239 Synthesis of DNA 0.755686 0.122
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.755686 0.122
R-HSA-9700206 Signaling by ALK in cancer 0.755686 0.122
R-HSA-2672351 Stimuli-sensing channels 0.758573 0.120
R-HSA-397014 Muscle contraction 0.760273 0.119
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.760273 0.119
R-HSA-5419276 Mitochondrial translation termination 0.761426 0.118
R-HSA-69002 DNA Replication Pre-Initiation 0.761426 0.118
R-HSA-9730414 MITF-M-regulated melanocyte development 0.762364 0.118
R-HSA-446203 Asparagine N-linked glycosylation 0.769365 0.114
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.783076 0.106
R-HSA-373760 L1CAM interactions 0.785640 0.105
R-HSA-70326 Glucose metabolism 0.788175 0.103
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.795571 0.099
R-HSA-8953854 Metabolism of RNA 0.796028 0.099
R-HSA-73886 Chromosome Maintenance 0.798020 0.098
R-HSA-3371556 Cellular response to heat stress 0.798020 0.098
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.798020 0.098
R-HSA-199991 Membrane Trafficking 0.804647 0.094
R-HSA-6809371 Formation of the cornified envelope 0.805103 0.094
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.809688 0.092
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.809688 0.092
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.809688 0.092
R-HSA-194138 Signaling by VEGF 0.809688 0.092
R-HSA-157118 Signaling by NOTCH 0.813140 0.090
R-HSA-168249 Innate Immune System 0.813648 0.090
R-HSA-8956319 Nucleotide catabolism 0.818537 0.087
R-HSA-5576891 Cardiac conduction 0.824905 0.084
R-HSA-9609646 HCMV Infection 0.829355 0.081
R-HSA-3858494 Beta-catenin independent WNT signaling 0.836980 0.077
R-HSA-9018519 Estrogen-dependent gene expression 0.836980 0.077
R-HSA-388841 Regulation of T cell activation by CD28 family 0.838469 0.077
R-HSA-5368287 Mitochondrial translation 0.840819 0.075
R-HSA-109582 Hemostasis 0.841727 0.075
R-HSA-9675108 Nervous system development 0.842356 0.075
R-HSA-1632852 Macroautophagy 0.846408 0.072
R-HSA-9734767 Developmental Cell Lineages 0.848546 0.071
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.850025 0.071
R-HSA-8856828 Clathrin-mediated endocytosis 0.851802 0.070
R-HSA-1266738 Developmental Biology 0.853062 0.069
R-HSA-9609507 Protein localization 0.868458 0.061
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.871558 0.060
R-HSA-9612973 Autophagy 0.873081 0.059
R-HSA-9610379 HCMV Late Events 0.874586 0.058
R-HSA-109581 Apoptosis 0.881848 0.055
R-HSA-162582 Signal Transduction 0.886651 0.052
R-HSA-1257604 PIP3 activates AKT signaling 0.887727 0.052
R-HSA-5619102 SLC transporter disorders 0.888693 0.051
R-HSA-392499 Metabolism of proteins 0.897368 0.047
R-HSA-611105 Respiratory electron transport 0.903552 0.044
R-HSA-422475 Axon guidance 0.903904 0.044
R-HSA-1280215 Cytokine Signaling in Immune system 0.904535 0.044
R-HSA-168255 Influenza Infection 0.904697 0.043
R-HSA-2559583 Cellular Senescence 0.905829 0.043
R-HSA-3781865 Diseases of glycosylation 0.910223 0.041
R-HSA-112315 Transmission across Chemical Synapses 0.914110 0.039
R-HSA-1643685 Disease 0.916732 0.038
R-HSA-1474244 Extracellular matrix organization 0.920511 0.036
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.921630 0.035
R-HSA-428157 Sphingolipid metabolism 0.926736 0.033
R-HSA-376176 Signaling by ROBO receptors 0.928468 0.032
R-HSA-9006925 Intracellular signaling by second messengers 0.928586 0.032
R-HSA-5653656 Vesicle-mediated transport 0.929394 0.032
R-HSA-6805567 Keratinization 0.931811 0.031
R-HSA-9006931 Signaling by Nuclear Receptors 0.941906 0.026
R-HSA-196854 Metabolism of vitamins and cofactors 0.942477 0.026
R-HSA-8951664 Neddylation 0.943020 0.025
R-HSA-5663205 Infectious disease 0.948827 0.023
R-HSA-15869 Metabolism of nucleotides 0.952395 0.021
R-HSA-8939211 ESR-mediated signaling 0.952963 0.021
R-HSA-156580 Phase II - Conjugation of compounds 0.954077 0.020
R-HSA-9824439 Bacterial Infection Pathways 0.956043 0.020
R-HSA-5619115 Disorders of transmembrane transporters 0.958279 0.019
R-HSA-425407 SLC-mediated transmembrane transport 0.959028 0.018
R-HSA-416476 G alpha (q) signalling events 0.965981 0.015
R-HSA-168256 Immune System 0.969122 0.014
R-HSA-76002 Platelet activation, signaling and aggregation 0.969832 0.013
R-HSA-72766 Translation 0.970377 0.013
R-HSA-112316 Neuronal System 0.980166 0.009
R-HSA-382551 Transport of small molecules 0.980219 0.009
R-HSA-449147 Signaling by Interleukins 0.983141 0.007
R-HSA-8957322 Metabolism of steroids 0.983475 0.007
R-HSA-388396 GPCR downstream signalling 0.985596 0.006
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.986539 0.006
R-HSA-372790 Signaling by GPCR 0.993205 0.003
R-HSA-418594 G alpha (i) signalling events 0.994014 0.003
R-HSA-556833 Metabolism of lipids 0.994081 0.003
R-HSA-5668914 Diseases of metabolism 0.995303 0.002
R-HSA-211859 Biological oxidations 0.998540 0.001
R-HSA-2262752 Cellular responses to stress 0.999688 0.000
R-HSA-9709957 Sensory Perception 0.999839 0.000
R-HSA-8953897 Cellular responses to stimuli 0.999921 0.000
R-HSA-1430728 Metabolism 0.999988 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.875 0.798 1 0.795
CDK17CDK17 0.871 0.862 1 0.891
CDK18CDK18 0.870 0.841 1 0.866
CDK19CDK19 0.869 0.821 1 0.848
P38GP38G 0.866 0.870 1 0.896
CDK8CDK8 0.864 0.820 1 0.813
CDK3CDK3 0.864 0.754 1 0.885
JNK2JNK2 0.863 0.868 1 0.862
CDK16CDK16 0.862 0.825 1 0.880
HIPK2HIPK2 0.862 0.771 1 0.837
P38DP38D 0.862 0.861 1 0.897
CDK1CDK1 0.862 0.815 1 0.842
CDK13CDK13 0.861 0.824 1 0.844
ERK1ERK1 0.860 0.828 1 0.847
CDK7CDK7 0.859 0.805 1 0.822
DYRK2DYRK2 0.857 0.767 1 0.754
CDK12CDK12 0.856 0.819 1 0.862
CDK14CDK14 0.855 0.821 1 0.833
P38BP38B 0.855 0.829 1 0.829
CDK5CDK5 0.854 0.780 1 0.796
DYRK4DYRK4 0.853 0.778 1 0.847
JNK3JNK3 0.853 0.851 1 0.836
CDK9CDK9 0.852 0.811 1 0.839
DYRK1BDYRK1B 0.851 0.752 1 0.817
ERK2ERK2 0.849 0.830 1 0.800
CDK10CDK10 0.846 0.756 1 0.849
P38AP38A 0.846 0.797 1 0.767
HIPK1HIPK1 0.843 0.699 1 0.741
CDK4CDK4 0.841 0.803 1 0.869
CLK3CLK3 0.841 0.488 1 0.532
NLKNLK 0.841 0.723 1 0.565
CDK6CDK6 0.840 0.779 1 0.852
HIPK4HIPK4 0.839 0.489 1 0.548
CDK2CDK2 0.838 0.645 1 0.723
DYRK1ADYRK1A 0.838 0.617 1 0.728
HIPK3HIPK3 0.837 0.686 1 0.717
JNK1JNK1 0.833 0.764 1 0.862
ERK5ERK5 0.833 0.413 1 0.479
CLK1CLK1 0.830 0.437 -3 0.699
SRPK1SRPK1 0.830 0.327 -3 0.692
DYRK3DYRK3 0.829 0.565 1 0.701
CLK4CLK4 0.826 0.410 -3 0.721
CLK2CLK2 0.821 0.412 -3 0.703
SRPK2SRPK2 0.818 0.258 -3 0.621
ICKICK 0.817 0.344 -3 0.787
COTCOT 0.817 -0.071 2 0.892
MTORMTOR 0.816 0.171 1 0.359
CDKL5CDKL5 0.811 0.141 -3 0.741
PRP4PRP4 0.810 0.458 -3 0.693
TBK1TBK1 0.810 -0.139 1 0.163
CDKL1CDKL1 0.809 0.119 -3 0.751
CDC7CDC7 0.808 -0.106 1 0.186
PRKD1PRKD1 0.807 0.026 -3 0.763
MAKMAK 0.807 0.472 -2 0.780
SRPK3SRPK3 0.807 0.221 -3 0.668
PRPKPRPK 0.806 -0.104 -1 0.872
IKKBIKKB 0.805 -0.142 -2 0.816
MOSMOS 0.805 -0.038 1 0.233
IKKEIKKE 0.805 -0.151 1 0.160
GCN2GCN2 0.804 -0.160 2 0.798
PRKD2PRKD2 0.804 0.034 -3 0.723
DSTYKDSTYK 0.803 -0.116 2 0.873
CAMK1BCAMK1B 0.803 -0.022 -3 0.821
PDHK4PDHK4 0.803 -0.144 1 0.244
RAF1RAF1 0.803 -0.171 1 0.182
ULK2ULK2 0.801 -0.181 2 0.810
PIM3PIM3 0.801 -0.055 -3 0.788
RIPK3RIPK3 0.801 -0.103 3 0.754
PKN3PKN3 0.801 -0.048 -3 0.782
ATRATR 0.800 -0.063 1 0.221
BMPR2BMPR2 0.800 -0.140 -2 0.915
NEK6NEK6 0.800 -0.075 -2 0.878
NUAK2NUAK2 0.800 0.002 -3 0.803
PDHK1PDHK1 0.800 -0.145 1 0.222
MOKMOK 0.799 0.437 1 0.629
NDR2NDR2 0.799 -0.046 -3 0.795
WNK1WNK1 0.798 -0.081 -2 0.899
NIKNIK 0.798 -0.054 -3 0.842
CHAK2CHAK2 0.798 -0.054 -1 0.885
NEK7NEK7 0.797 -0.149 -3 0.826
MST4MST4 0.797 -0.054 2 0.836
CAMK2GCAMK2G 0.797 -0.097 2 0.777
TGFBR2TGFBR2 0.797 -0.073 -2 0.851
ERK7ERK7 0.796 0.258 2 0.539
CAMLCKCAMLCK 0.796 -0.001 -2 0.903
ULK1ULK1 0.795 -0.150 -3 0.791
SKMLCKSKMLCK 0.795 -0.046 -2 0.900
PIM1PIM1 0.795 0.010 -3 0.739
IKKAIKKA 0.795 -0.084 -2 0.796
MAPKAPK3MAPKAPK3 0.795 -0.048 -3 0.729
NDR1NDR1 0.794 -0.064 -3 0.789
HUNKHUNK 0.794 -0.143 2 0.813
RSK2RSK2 0.793 -0.021 -3 0.723
PAK6PAK6 0.793 0.039 -2 0.784
BCKDKBCKDK 0.793 -0.120 -1 0.842
AMPKA1AMPKA1 0.793 -0.071 -3 0.811
DAPK2DAPK2 0.792 -0.036 -3 0.826
PKCDPKCD 0.792 -0.040 2 0.795
MLK1MLK1 0.792 -0.159 2 0.817
GRK1GRK1 0.792 -0.036 -2 0.824
P90RSKP90RSK 0.792 -0.028 -3 0.721
GRK5GRK5 0.791 -0.136 -3 0.827
P70S6KBP70S6KB 0.791 -0.018 -3 0.753
PKN2PKN2 0.791 -0.079 -3 0.792
NEK9NEK9 0.791 -0.161 2 0.854
MAPKAPK2MAPKAPK2 0.790 -0.031 -3 0.681
WNK3WNK3 0.790 -0.196 1 0.180
AURCAURC 0.790 0.034 -2 0.719
PINK1PINK1 0.789 0.185 1 0.395
NUAK1NUAK1 0.789 -0.028 -3 0.754
LATS2LATS2 0.789 -0.058 -5 0.790
CAMK2DCAMK2D 0.789 -0.103 -3 0.804
ALK4ALK4 0.789 -0.016 -2 0.887
GRK6GRK6 0.789 -0.106 1 0.170
IRE1IRE1 0.789 -0.106 1 0.178
MARK4MARK4 0.788 -0.097 4 0.836
PRKD3PRKD3 0.788 -0.000 -3 0.690
ATMATM 0.788 -0.071 1 0.185
AMPKA2AMPKA2 0.788 -0.055 -3 0.778
MLK2MLK2 0.788 -0.134 2 0.838
CAMK4CAMK4 0.788 -0.084 -3 0.788
ANKRD3ANKRD3 0.788 -0.142 1 0.196
MELKMELK 0.788 -0.067 -3 0.763
TSSK2TSSK2 0.787 -0.079 -5 0.869
MASTLMASTL 0.787 -0.185 -2 0.864
TGFBR1TGFBR1 0.787 -0.018 -2 0.863
NIM1NIM1 0.787 -0.104 3 0.757
PKACGPKACG 0.787 -0.035 -2 0.787
RIPK1RIPK1 0.786 -0.183 1 0.169
MNK2MNK2 0.786 -0.019 -2 0.850
TSSK1TSSK1 0.786 -0.059 -3 0.829
RSK3RSK3 0.786 -0.048 -3 0.711
PKRPKR 0.786 -0.071 1 0.200
PLK1PLK1 0.785 -0.109 -2 0.851
PHKG1PHKG1 0.785 -0.072 -3 0.785
DNAPKDNAPK 0.785 -0.050 1 0.210
BMPR1BBMPR1B 0.785 -0.033 1 0.153
PAK3PAK3 0.784 -0.056 -2 0.839
LATS1LATS1 0.784 -0.005 -3 0.807
IRE2IRE2 0.784 -0.098 2 0.782
DLKDLK 0.784 -0.199 1 0.180
PAK1PAK1 0.784 -0.037 -2 0.835
NEK2NEK2 0.783 -0.118 2 0.823
MLK3MLK3 0.782 -0.096 2 0.738
MSK2MSK2 0.782 -0.041 -3 0.687
CHK1CHK1 0.782 -0.028 -3 0.789
YSK4YSK4 0.782 -0.146 1 0.163
VRK2VRK2 0.781 0.005 1 0.278
AURBAURB 0.781 0.009 -2 0.719
PKCZPKCZ 0.781 -0.057 2 0.798
MNK1MNK1 0.781 -0.016 -2 0.860
GRK7GRK7 0.780 -0.023 1 0.202
GRK4GRK4 0.780 -0.151 -2 0.845
PKCAPKCA 0.780 -0.052 2 0.736
QIKQIK 0.779 -0.112 -3 0.803
QSKQSK 0.779 -0.061 4 0.812
CAMK2BCAMK2B 0.779 -0.070 2 0.751
AKT2AKT2 0.779 0.017 -3 0.643
PKCBPKCB 0.778 -0.065 2 0.747
PAK2PAK2 0.778 -0.055 -2 0.832
FAM20CFAM20C 0.778 -0.023 2 0.585
GSK3AGSK3A 0.778 0.187 4 0.490
PKACBPKACB 0.778 0.020 -2 0.728
PKG2PKG2 0.778 -0.008 -2 0.722
MEK1MEK1 0.778 -0.132 2 0.835
SMG1SMG1 0.777 -0.094 1 0.205
CHAK1CHAK1 0.777 -0.150 2 0.781
ALK2ALK2 0.777 -0.046 -2 0.867
ACVR2AACVR2A 0.777 -0.073 -2 0.839
MYLK4MYLK4 0.777 -0.028 -2 0.832
PKCGPKCG 0.776 -0.076 2 0.731
ACVR2BACVR2B 0.776 -0.077 -2 0.850
PIM2PIM2 0.776 -0.002 -3 0.701
CAMK2ACAMK2A 0.776 -0.051 2 0.740
PERKPERK 0.776 -0.114 -2 0.889
MAPKAPK5MAPKAPK5 0.776 -0.087 -3 0.673
TTBK2TTBK2 0.776 -0.214 2 0.711
HRIHRI 0.775 -0.131 -2 0.883
PKCHPKCH 0.775 -0.082 2 0.735
SIKSIK 0.774 -0.071 -3 0.719
MPSK1MPSK1 0.774 0.008 1 0.259
SGK3SGK3 0.774 -0.030 -3 0.710
MLK4MLK4 0.774 -0.130 2 0.732
RSK4RSK4 0.774 -0.027 -3 0.696
CAMK1GCAMK1G 0.774 -0.061 -3 0.724
PLK3PLK3 0.774 -0.119 2 0.742
MSK1MSK1 0.774 -0.027 -3 0.692
BRSK2BRSK2 0.773 -0.110 -3 0.779
NEK5NEK5 0.772 -0.121 1 0.181
IRAK4IRAK4 0.772 -0.127 1 0.163
PRKXPRKX 0.772 0.028 -3 0.639
BRAFBRAF 0.771 -0.107 -4 0.830
PHKG2PHKG2 0.771 -0.077 -3 0.759
BRSK1BRSK1 0.771 -0.094 -3 0.746
SNRKSNRK 0.771 -0.159 2 0.705
BMPR1ABMPR1A 0.771 -0.038 1 0.142
MEKK1MEKK1 0.771 -0.152 1 0.186
PAK5PAK5 0.771 -0.006 -2 0.725
TLK2TLK2 0.770 -0.135 1 0.158
AKT1AKT1 0.770 0.003 -3 0.663
PLK4PLK4 0.770 -0.147 2 0.656
WNK4WNK4 0.770 -0.134 -2 0.887
AURAAURA 0.770 -0.007 -2 0.695
ZAKZAK 0.769 -0.156 1 0.160
MARK2MARK2 0.769 -0.084 4 0.729
MEK5MEK5 0.769 -0.168 2 0.832
MARK3MARK3 0.768 -0.079 4 0.765
GRK2GRK2 0.768 -0.090 -2 0.737
MEKK3MEKK3 0.768 -0.169 1 0.180
DRAK1DRAK1 0.768 -0.164 1 0.148
SMMLCKSMMLCK 0.768 -0.029 -3 0.774
PAK4PAK4 0.767 0.002 -2 0.731
GSK3BGSK3B 0.767 0.048 4 0.481
PKCIPKCI 0.767 -0.037 2 0.754
DCAMKL1DCAMKL1 0.767 -0.073 -3 0.738
TAO3TAO3 0.767 -0.063 1 0.208
MST3MST3 0.766 -0.083 2 0.820
P70S6KP70S6K 0.766 -0.051 -3 0.661
PKCTPKCT 0.766 -0.076 2 0.753
DCAMKL2DCAMKL2 0.766 -0.067 -3 0.770
MEKK2MEKK2 0.766 -0.142 2 0.824
GAKGAK 0.765 -0.022 1 0.253
MARK1MARK1 0.764 -0.105 4 0.790
SBKSBK 0.764 0.108 -3 0.528
CAMK1DCAMK1D 0.764 -0.037 -3 0.655
PKACAPKACA 0.764 0.006 -2 0.676
SSTKSSTK 0.763 -0.075 4 0.796
CK1ECK1E 0.763 -0.016 -3 0.578
TLK1TLK1 0.762 -0.137 -2 0.851
NEK8NEK8 0.762 -0.152 2 0.825
LKB1LKB1 0.762 -0.051 -3 0.814
TAO2TAO2 0.761 -0.075 2 0.853
IRAK1IRAK1 0.761 -0.189 -1 0.789
PKN1PKN1 0.760 -0.050 -3 0.682
PASKPASK 0.760 -0.073 -3 0.808
CAMKK1CAMKK1 0.760 -0.156 -2 0.840
CAMKK2CAMKK2 0.760 -0.107 -2 0.848
NEK11NEK11 0.760 -0.155 1 0.203
NEK4NEK4 0.760 -0.139 1 0.169
BUB1BUB1 0.759 0.051 -5 0.833
CK1DCK1D 0.759 0.013 -3 0.533
PDK1PDK1 0.758 -0.094 1 0.222
PKCEPKCE 0.758 -0.028 2 0.715
CK2A2CK2A2 0.757 -0.065 1 0.134
LOKLOK 0.757 -0.063 -2 0.831
HGKHGK 0.757 -0.091 3 0.831
GCKGCK 0.756 -0.096 1 0.195
TTBK1TTBK1 0.756 -0.171 2 0.621
PBKPBK 0.756 -0.023 1 0.239
MST2MST2 0.756 -0.120 1 0.176
DAPK3DAPK3 0.755 -0.033 -3 0.757
TNIKTNIK 0.755 -0.063 3 0.836
AKT3AKT3 0.755 0.003 -3 0.573
CHK2CHK2 0.755 -0.029 -3 0.587
NEK1NEK1 0.754 -0.132 1 0.164
MINKMINK 0.754 -0.128 1 0.170
CAMK1ACAMK1A 0.754 -0.022 -3 0.601
LRRK2LRRK2 0.754 -0.054 2 0.845
SLKSLK 0.754 -0.050 -2 0.776
RIPK2RIPK2 0.753 -0.175 1 0.150
SGK1SGK1 0.753 0.010 -3 0.559
CK1A2CK1A2 0.753 -0.012 -3 0.532
CK1G1CK1G1 0.752 -0.061 -3 0.561
HPK1HPK1 0.752 -0.097 1 0.196
GRK3GRK3 0.751 -0.093 -2 0.689
MAP3K15MAP3K15 0.751 -0.148 1 0.177
MEKK6MEKK6 0.751 -0.144 1 0.181
EEF2KEEF2K 0.751 -0.106 3 0.786
MRCKAMRCKA 0.751 -0.017 -3 0.715
MRCKBMRCKB 0.750 -0.013 -3 0.694
KHS1KHS1 0.750 -0.074 1 0.188
CK2A1CK2A1 0.749 -0.071 1 0.125
DAPK1DAPK1 0.749 -0.041 -3 0.738
TAK1TAK1 0.749 -0.184 1 0.165
BIKEBIKE 0.749 -0.007 1 0.252
MST1MST1 0.748 -0.135 1 0.166
NEK3NEK3 0.748 -0.103 1 0.185
KHS2KHS2 0.748 -0.051 1 0.201
HASPINHASPIN 0.747 -0.006 -1 0.696
ROCK2ROCK2 0.747 -0.023 -3 0.740
VRK1VRK1 0.747 -0.185 2 0.872
STK33STK33 0.746 -0.139 2 0.602
YSK1YSK1 0.745 -0.134 2 0.818
PLK2PLK2 0.745 -0.083 -3 0.766
PKG1PKG1 0.743 -0.030 -2 0.644
DMPK1DMPK1 0.743 0.019 -3 0.718
PDHK3_TYRPDHK3_TYR 0.742 0.109 4 0.914
MEK2MEK2 0.741 -0.204 2 0.831
AAK1AAK1 0.740 0.020 1 0.261
TTKTTK 0.739 -0.072 -2 0.857
ROCK1ROCK1 0.737 -0.024 -3 0.707
TAO1TAO1 0.737 -0.087 1 0.176
CRIKCRIK 0.736 -0.017 -3 0.657
TESK1_TYRTESK1_TYR 0.736 0.027 3 0.845
OSR1OSR1 0.735 -0.089 2 0.815
LIMK2_TYRLIMK2_TYR 0.735 0.094 -3 0.853
PDHK4_TYRPDHK4_TYR 0.734 0.047 2 0.855
MYO3BMYO3B 0.733 -0.092 2 0.824
PKMYT1_TYRPKMYT1_TYR 0.733 0.075 3 0.826
ASK1ASK1 0.731 -0.150 1 0.176
MYO3AMYO3A 0.731 -0.103 1 0.186
MAP2K4_TYRMAP2K4_TYR 0.731 -0.017 -1 0.880
MAP2K7_TYRMAP2K7_TYR 0.729 -0.107 2 0.846
MAP2K6_TYRMAP2K6_TYR 0.729 0.001 -1 0.887
PINK1_TYRPINK1_TYR 0.728 -0.119 1 0.231
BMPR2_TYRBMPR2_TYR 0.727 -0.005 -1 0.886
PDHK1_TYRPDHK1_TYR 0.726 -0.067 -1 0.906
MST1RMST1R 0.726 -0.068 3 0.810
RETRET 0.725 -0.115 1 0.196
ALPHAK3ALPHAK3 0.725 -0.102 -1 0.807
CSF1RCSF1R 0.724 -0.065 3 0.809
LIMK1_TYRLIMK1_TYR 0.724 -0.032 2 0.859
JAK2JAK2 0.723 -0.102 1 0.204
TYK2TYK2 0.722 -0.181 1 0.185
EPHA6EPHA6 0.722 -0.080 -1 0.916
NEK10_TYRNEK10_TYR 0.720 -0.096 1 0.180
EPHB4EPHB4 0.719 -0.101 -1 0.899
ROS1ROS1 0.719 -0.139 3 0.759
STLK3STLK3 0.719 -0.179 1 0.146
JAK3JAK3 0.718 -0.099 1 0.182
ABL2ABL2 0.718 -0.068 -1 0.848
TYRO3TYRO3 0.717 -0.158 3 0.790
FGFR2FGFR2 0.716 -0.034 3 0.773
DDR1DDR1 0.716 -0.124 4 0.810
YANK3YANK3 0.716 -0.079 2 0.370
YES1YES1 0.716 -0.093 -1 0.872
FGFR1FGFR1 0.715 -0.027 3 0.750
ABL1ABL1 0.715 -0.069 -1 0.844
INSRRINSRR 0.715 -0.110 3 0.739
JAK1JAK1 0.714 -0.103 1 0.175
TNNI3K_TYRTNNI3K_TYR 0.714 -0.057 1 0.207
TEKTEK 0.714 -0.018 3 0.730
KDRKDR 0.714 -0.062 3 0.766
TNK1TNK1 0.713 -0.079 3 0.775
KITKIT 0.713 -0.098 3 0.807
TXKTXK 0.713 -0.093 1 0.150
CK1ACK1A 0.712 -0.046 -3 0.447
HCKHCK 0.711 -0.128 -1 0.858
PDGFRBPDGFRB 0.711 -0.174 3 0.798
EPHA4EPHA4 0.711 -0.085 2 0.727
FLT3FLT3 0.710 -0.145 3 0.786
LCKLCK 0.710 -0.090 -1 0.863
EPHB3EPHB3 0.710 -0.129 -1 0.893
FGRFGR 0.710 -0.171 1 0.175
TNK2TNK2 0.710 -0.131 3 0.745
FERFER 0.709 -0.185 1 0.176
EPHB1EPHB1 0.708 -0.157 1 0.149
PDGFRAPDGFRA 0.708 -0.173 3 0.801
BLKBLK 0.707 -0.081 -1 0.865
EPHB2EPHB2 0.707 -0.126 -1 0.887
AXLAXL 0.707 -0.153 3 0.777
FGFR3FGFR3 0.705 -0.052 3 0.755
WEE1_TYRWEE1_TYR 0.705 -0.087 -1 0.785
MERTKMERTK 0.705 -0.142 3 0.777
SRMSSRMS 0.705 -0.182 1 0.147
METMET 0.704 -0.103 3 0.792
ITKITK 0.703 -0.166 -1 0.835
FLT4FLT4 0.703 -0.114 3 0.749
ERBB2ERBB2 0.702 -0.143 1 0.164
DDR2DDR2 0.702 -0.044 3 0.721
FLT1FLT1 0.702 -0.108 -1 0.878
ALKALK 0.701 -0.156 3 0.707
TECTEC 0.701 -0.136 -1 0.785
NTRK1NTRK1 0.701 -0.175 -1 0.864
NTRK2NTRK2 0.701 -0.169 3 0.760
FYNFYN 0.700 -0.085 -1 0.839
EPHA7EPHA7 0.700 -0.127 2 0.746
INSRINSR 0.700 -0.143 3 0.721
LTKLTK 0.700 -0.160 3 0.732
EPHA1EPHA1 0.698 -0.143 3 0.772
FRKFRK 0.698 -0.140 -1 0.867
PTK2BPTK2B 0.698 -0.082 -1 0.831
NTRK3NTRK3 0.697 -0.133 -1 0.819
EPHA3EPHA3 0.697 -0.131 2 0.713
BMXBMX 0.697 -0.138 -1 0.759
CK1G3CK1G3 0.696 -0.042 -3 0.401
BTKBTK 0.696 -0.224 -1 0.798
MUSKMUSK 0.696 -0.112 1 0.125
PTK6PTK6 0.696 -0.200 -1 0.778
LYNLYN 0.695 -0.129 3 0.719
EGFREGFR 0.695 -0.104 1 0.130
EPHA5EPHA5 0.694 -0.118 2 0.723
EPHA8EPHA8 0.693 -0.110 -1 0.869
SRCSRC 0.692 -0.113 -1 0.842
FGFR4FGFR4 0.691 -0.095 -1 0.822
MATKMATK 0.691 -0.105 -1 0.786
PTK2PTK2 0.687 -0.056 -1 0.837
CSKCSK 0.686 -0.158 2 0.750
SYKSYK 0.684 -0.078 -1 0.818
ERBB4ERBB4 0.684 -0.089 1 0.132
EPHA2EPHA2 0.684 -0.116 -1 0.835
IGF1RIGF1R 0.683 -0.137 3 0.663
YANK2YANK2 0.680 -0.099 2 0.385
ZAP70ZAP70 0.671 -0.049 -1 0.736
CK1G2CK1G2 0.669 -0.060 -3 0.488
FESFES 0.668 -0.148 -1 0.753