Motif 15 (n=180)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A1L170 | C1orf226 | S223 | ochoa | Uncharacterized protein C1orf226 | None |
B8ZZF3 | None | S186 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
O00429 | DNM1L | S126 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
O14523 | C2CD2L | S464 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
O14647 | CHD2 | S1365 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
O14686 | KMT2D | S4883 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14936 | CASK | S395 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
O15018 | PDZD2 | S1988 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
O15360 | FANCA | S1377 | ochoa | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
O43704 | SULT1B1 | S92 | ochoa | Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). {ECO:0000269|PubMed:28084139, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}. |
O60711 | LPXN | S188 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
O94885 | SASH1 | S297 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
O94906 | PRPF6 | S279 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
O95292 | VAPB | S206 | ochoa | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
O95402 | MED26 | S178 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
P00918 | CA2 | S29 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
P10914 | IRF1 | S215 | psp | Interferon regulatory factor 1 (IRF-1) | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essentail role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}. |
P13639 | EEF2 | S502 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
P13639 | EEF2 | S595 | ochoa|psp | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
P13995 | MTHFD2 | S149 | ochoa | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] | Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. {ECO:0000269|PubMed:16100107}. |
P14866 | HNRNPL | S291 | ochoa | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
P17028 | ZNF24 | S63 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
P23508 | MCC | S294 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
P24864 | CCNE1 | S103 | ochoa|psp | G1/S-specific cyclin-E1 | Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}. |
P32189 | GK | S125 | ochoa | Glycerol kinase (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) | Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis. {ECO:0000269|PubMed:15845384, ECO:0000269|PubMed:37021775}. |
P33240 | CSTF2 | S154 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
P35606 | COPB2 | S859 | ochoa|psp | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
P42575 | CASP2 | S340 | ochoa|psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
P43007 | SLC1A4 | S507 | ochoa | Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) | Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}. |
P46013 | MKI67 | S1131 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S1253 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S1983 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S2223 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S2344 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S2466 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46019 | PHKA2 | S735 | ochoa | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
P46020 | PHKA1 | S735 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
P46100 | ATRX | S1996 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46821 | MAP1B | S1965 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P50570 | DNM2 | S116 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P51149 | RAB7A | S111 | ochoa | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
P51948 | MNAT1 | S279 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
P78332 | RBM6 | S1025 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
P78395 | PRAME | S277 | ochoa | Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma) | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254). {ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}. |
P81274 | GPSM2 | S541 | ochoa | G-protein-signaling modulator 2 (Mosaic protein LGN) | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}. |
P84157 | MXRA7 | S144 | ochoa | Matrix-remodeling-associated protein 7 | None |
Q01860 | POU5F1 | S111 | psp | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
Q01974 | ROR2 | S569 | ochoa | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) | Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}. |
Q03001 | DST | S2215 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
Q03164 | KMT2A | S3053 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q06413 | MEF2C | S240 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
Q06546 | GABPA | S309 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
Q06945 | SOX4 | S81 | ochoa | Transcription factor SOX-4 | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}. |
Q08J23 | NSUN2 | S473 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
Q12770 | SCAP | S907 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
Q13263 | TRIM28 | S757 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13323 | BIK | S124 | psp | Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}. |
Q13469 | NFATC2 | S110 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q14004 | CDK13 | S525 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Q14139 | UBE4A | S551 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
Q14155 | ARHGEF7 | S518 | ochoa|psp | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
Q14409 | GK3 | S125 | ochoa | Glycerol kinase 3 (GK 3) (Glycerokinase 3) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 3) (Glycerol kinase 3 pseudogene) (Glycerol kinase, testis specific 1) | May be involved in the regulation of glycerol uptake and metabolism. {ECO:0000305}. |
Q14789 | GOLGB1 | S3016 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
Q14CS0 | UBXN2B | S56 | ochoa|psp | UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) | Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}. |
Q15052 | ARHGEF6 | S488 | ochoa|psp | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
Q15345 | LRRC41 | S155 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
Q15468 | STIL | S1111 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
Q15652 | JMJD1C | S1185 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
Q16828 | DUSP6 | S331 | ochoa | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
Q16829 | DUSP7 | S369 | ochoa | Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) | Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). {ECO:0000250|UniProtKB:Q91Z46, ECO:0000269|PubMed:9788880}. |
Q1AE95 | TMEM183BP | S336 | ochoa | Putative transmembrane protein 183BP (Transmembrane protein 183B pseudogene) | None |
Q4KWH8 | PLCH1 | S1386 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
Q562F6 | SGO2 | S1144 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
Q56NI9 | ESCO2 | S29 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
Q5T4S7 | UBR4 | S660 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
Q5T8I9 | HENMT1 | S329 | ochoa | Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}. |
Q5T8P6 | RBM26 | S518 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
Q5U623 | ATF7IP2 | S488 | ochoa | Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}. |
Q5UIP0 | RIF1 | S782 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q5VUA4 | ZNF318 | S2091 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
Q5VV67 | PPRC1 | S771 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
Q5VVJ2 | MYSM1 | S110 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
Q5VZ89 | DENND4C | S741 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q69YH5 | CDCA2 | S437 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
Q6MZQ0 | PRR5L | S29 | ochoa | Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) | Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}. |
Q6S5L8 | SHC4 | S132 | ochoa|psp | SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) | Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}. |
Q6TFL4 | KLHL24 | S19 | ochoa | Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) | Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062, ECO:0000269|PubMed:30715372}. |
Q6UB99 | ANKRD11 | S860 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6VY07 | PACS1 | S534 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
Q6XR72 | SLC30A10 | S402 | ochoa | Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10) | Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129). {ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481}. |
Q6ZWE6 | PLEKHM3 | S350 | ochoa | Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}. |
Q70CQ3 | USP30 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}. |
Q71F56 | MED13L | S826 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
Q7L7X3 | TAOK1 | S177 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
Q7Z333 | SETX | S1330 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
Q7Z4H7 | HAUS6 | S507 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
Q7Z589 | EMSY | S1136 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
Q7Z698 | SPRED2 | S104 | ochoa | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}. |
Q7Z6G8 | ANKS1B | S310 | ochoa | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
Q7Z6Z7 | HUWE1 | S3127 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
Q7Z6Z7 | HUWE1 | S3373 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
Q86SQ0 | PHLDB2 | S909 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86TC9 | MYPN | S386 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
Q86TU7 | SETD3 | S38 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
Q86YA3 | ZGRF1 | S880 | ochoa | 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) | 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219). {ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:34552057}. |
Q8IUF8 | RIOX2 | S47 | ochoa | Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}. |
Q8IX01 | SUGP2 | S773 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
Q8IXX5 | TMEM183A | S336 | ochoa | Transmembrane protein 183A | None |
Q8IYH5 | ZZZ3 | S606 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
Q8IZ21 | PHACTR4 | S427 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
Q8IZ73 | RPUSD2 | S436 | ochoa | Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
Q8N4X5 | AFAP1L2 | S213 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
Q8N883 | ZNF614 | S92 | ochoa | Zinc finger protein 614 | May be involved in transcriptional regulation. |
Q8NCF5 | NFATC2IP | S234 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
Q8NI77 | KIF18A | S674 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
Q8TEQ6 | GEMIN5 | S1267 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
Q8WY36 | BBX | S844 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
Q8WYP5 | AHCTF1 | S1283 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
Q92539 | LPIN2 | S229 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
Q92576 | PHF3 | S1184 | ochoa | PHD finger protein 3 | None |
Q92817 | EVPL | S1698 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
Q96CU9 | FOXRED1 | S189 | ochoa | FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) | Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}. |
Q96DA6 | DNAJC19 | S70 | ochoa | Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19) | Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}. |
Q96E22 | NUS1 | S168 | ochoa | Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466, ECO:0000269|PubMed:33077723}. |
Q96FI4 | NEIL1 | S207 | ochoa|psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
Q96GX5 | MASTL | S370 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
Q96HA1 | POM121 | S108 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
Q96HH9 | GRAMD2B | S225 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
Q96JH7 | VCPIP1 | S131 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
Q96RU2 | USP28 | S279 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
Q96RY5 | CRAMP1 | S533 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
Q99728 | BARD1 | S496 | ochoa | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
Q99956 | DUSP9 | S328 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
Q9BPX5 | ARPC5L | S64 | ochoa | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
Q9BQE4 | SELENOS | S140 | ochoa | Selenoprotein S (SelS) (VCP-interacting membrane protein) | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}. |
Q9BV36 | MLPH | S444 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BW91 | NUDT9 | S121 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
Q9BX63 | BRIP1 | S956 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
Q9BX66 | SORBS1 | S556 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
Q9BXC9 | BBS2 | S365 | ochoa | BBSome complex member BBS2 (Bardet-Biedl syndrome 2 protein) | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}. |
Q9BYW2 | SETD2 | S131 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9C0B5 | ZDHHC5 | S247 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
Q9H270 | VPS11 | S813 | ochoa | Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). {ECO:0000269|PubMed:21148287, ECO:0000269|PubMed:23593995, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24554770, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}. |
Q9H2D6 | TRIOBP | S1796 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
Q9H2F5 | EPC1 | S427 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
Q9H2K8 | TAOK3 | S173 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
Q9H2T7 | RANBP17 | S296 | ochoa | Ran-binding protein 17 | May function as a nuclear transport receptor. {ECO:0000250}. |
Q9H501 | ESF1 | S198 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
Q9H972 | C14orf93 | S285 | ochoa | Uncharacterized protein C14orf93 | None |
Q9HAU0 | PLEKHA5 | S607 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
Q9NS56 | TOPORS | S194 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
Q9NUQ2 | AGPAT5 | S298 | ochoa | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) | Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). {ECO:0000269|PubMed:21173190}. |
Q9NVS9 | PNPO | S241 | ochoa | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}. |
Q9NX95 | SYBU | S396 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
Q9NY74 | ETAA1 | S95 | ochoa|psp | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
Q9NYF8 | BCLAF1 | S531 | ochoa|psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
Q9UBU7 | DBF4 | S629 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
Q9UHG0 | DCDC2 | S270 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
Q9UIF9 | BAZ2A | S613 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
Q9UJF2 | RASAL2 | S946 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Q9UL03 | INTS6 | S150 | ochoa | Integrator complex subunit 6 (Int6) (DBI-1) (Protein deleted in cancer 1) (DICE1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:39504960}. |
Q9ULD2 | MTUS1 | S443 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9ULV3 | CIZ1 | S838 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
Q9UNA4 | POLI | S502 | ochoa | DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) | Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}. |
Q9UPQ4 | TRIM35 | S65 | ochoa | E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}. |
Q9UPU7 | TBC1D2B | S155 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
Q9Y210 | TRPC6 | S282 | psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
Q9Y4C1 | KDM3A | S283 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
Q9Y673 | ALG5 | S62 | ochoa | Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) | Dolichyl-phosphate beta-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Dolichyl-phosphate beta-glucosyltransferase produces dolichyl beta-D-glucosyl phosphate/Dol-P-Glc, the glucose donor substrate used sequentially by ALG6, ALG8 and ALG10 to add glucose residues on top of the Man(9)GlcNAc(2)-PP-Dol structure. These are the three last steps in the biosynthetic pathway of dolichol-linked oligosaccharides to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol. The enzyme is most probably active on the cytoplasmic side of the endoplasmic reticulum while its product Dol-P-Glc is the substrate for ALG6, ALG8 and ALG11 in the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:10359825, ECO:0000269|PubMed:35896117}. |
Q9Y6K1 | DNMT3A | S75 | ochoa | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
Q9Y6X0 | SETBP1 | S611 | ochoa | SET-binding protein (SEB) | None |
Q9Y6X8 | ZHX2 | S719 | ochoa | Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}. |
O00444 | PLK4 | S499 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
Q13547 | HDAC1 | S88 | Sugiyama | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
Q92769 | HDAC2 | S89 | Sugiyama | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
P20020 | ATP2B1 | S1178 | ELM|iPTMNet|EPSD | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}. |
Q6EMK4 | VASN | S322 | Sugiyama | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
Q13873 | BMPR2 | S233 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
P50990 | CCT8 | S161 | Sugiyama | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
Q9UQ07 | MOK | S365 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9652817 | Signaling by MAPK mutants | 0.000129 | 3.890 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.000248 | 3.606 |
R-HSA-4839726 | Chromatin organization | 0.000400 | 3.398 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.002379 | 2.624 |
R-HSA-198753 | ERK/MAPK targets | 0.003782 | 2.422 |
R-HSA-1640170 | Cell Cycle | 0.002670 | 2.573 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.002675 | 2.573 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.004392 | 2.357 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.004644 | 2.333 |
R-HSA-75109 | Triglyceride biosynthesis | 0.007284 | 2.138 |
R-HSA-9022707 | MECP2 regulates transcription factors | 0.006408 | 2.193 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.008542 | 2.068 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.009087 | 2.042 |
R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 0.011730 | 1.931 |
R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.015665 | 1.805 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.014836 | 1.829 |
R-HSA-202670 | ERKs are inactivated | 0.013874 | 1.858 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.013906 | 1.857 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.012179 | 1.914 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.013054 | 1.884 |
R-HSA-69205 | G1/S-Specific Transcription | 0.014797 | 1.830 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.015462 | 1.811 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.010298 | 1.987 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.015720 | 1.804 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.023323 | 1.632 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.023323 | 1.632 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.023323 | 1.632 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.023323 | 1.632 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.023323 | 1.632 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.023323 | 1.632 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.023323 | 1.632 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.016674 | 1.778 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.021852 | 1.661 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.021487 | 1.668 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.019525 | 1.709 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.021923 | 1.659 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.021073 | 1.676 |
R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.017549 | 1.756 |
R-HSA-9659379 | Sensory processing of sound | 0.020313 | 1.692 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.018187 | 1.740 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.021589 | 1.666 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.020809 | 1.682 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.025139 | 1.600 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.026005 | 1.585 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.026005 | 1.585 |
R-HSA-69206 | G1/S Transition | 0.026046 | 1.584 |
R-HSA-9675135 | Diseases of DNA repair | 0.026698 | 1.574 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.025973 | 1.585 |
R-HSA-9827857 | Specification of primordial germ cells | 0.028289 | 1.548 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.031575 | 1.501 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.033158 | 1.479 |
R-HSA-9754189 | Germ layer formation at gastrulation | 0.033158 | 1.479 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.035706 | 1.447 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.035706 | 1.447 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.035706 | 1.447 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.035706 | 1.447 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.035706 | 1.447 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.040859 | 1.389 |
R-HSA-4755609 | Defective DHDDS causes RP59 | 0.046105 | 1.336 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.057297 | 1.242 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.057297 | 1.242 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.052462 | 1.280 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.047393 | 1.324 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.043478 | 1.362 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.057297 | 1.242 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.043781 | 1.359 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.045879 | 1.338 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.055480 | 1.256 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.046091 | 1.336 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.049923 | 1.302 |
R-HSA-376172 | DSCAM interactions | 0.046105 | 1.336 |
R-HSA-5689901 | Metalloprotease DUBs | 0.055480 | 1.256 |
R-HSA-68877 | Mitotic Prometaphase | 0.041009 | 1.387 |
R-HSA-3214842 | HDMs demethylate histones | 0.052462 | 1.280 |
R-HSA-68886 | M Phase | 0.050983 | 1.293 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.056206 | 1.250 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.052462 | 1.280 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.055480 | 1.256 |
R-HSA-8979227 | Triglyceride metabolism | 0.045714 | 1.340 |
R-HSA-450294 | MAP kinase activation | 0.049102 | 1.309 |
R-HSA-73887 | Death Receptor Signaling | 0.054365 | 1.265 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.061890 | 1.208 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.064887 | 1.188 |
R-HSA-418360 | Platelet calcium homeostasis | 0.064887 | 1.188 |
R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.068359 | 1.165 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.081630 | 1.088 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.065802 | 1.182 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.078183 | 1.107 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.081630 | 1.088 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.074783 | 1.126 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.078183 | 1.107 |
R-HSA-1538133 | G0 and Early G1 | 0.074783 | 1.126 |
R-HSA-9636569 | Suppression of autophagy | 0.079291 | 1.101 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.070725 | 1.150 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.078193 | 1.107 |
R-HSA-205025 | NADE modulates death signalling | 0.068359 | 1.165 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.077021 | 1.113 |
R-HSA-9733709 | Cardiogenesis | 0.078183 | 1.107 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.081267 | 1.090 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.071877 | 1.143 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.078183 | 1.107 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.078183 | 1.107 |
R-HSA-448424 | Interleukin-17 signaling | 0.065802 | 1.182 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.082535 | 1.083 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.085123 | 1.070 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.085123 | 1.070 |
R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.090096 | 1.045 |
R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.100774 | 0.997 |
R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.111328 | 0.953 |
R-HSA-418886 | Netrin mediated repulsion signals | 0.111328 | 0.953 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.132067 | 0.879 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.142256 | 0.847 |
R-HSA-390450 | Folding of actin by CCT/TriC | 0.142256 | 0.847 |
R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.162277 | 0.790 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.162277 | 0.790 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.181834 | 0.740 |
R-HSA-418885 | DCC mediated attractive signaling | 0.200936 | 0.697 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.210320 | 0.677 |
R-HSA-5656121 | Translesion synthesis by POLI | 0.210320 | 0.677 |
R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.219595 | 0.658 |
R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.219595 | 0.658 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.150184 | 0.823 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.289993 | 0.538 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.289993 | 0.538 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.298337 | 0.525 |
R-HSA-191859 | snRNP Assembly | 0.187653 | 0.727 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.187653 | 0.727 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.204700 | 0.689 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.204700 | 0.689 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.346388 | 0.460 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.217594 | 0.662 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.247916 | 0.606 |
R-HSA-380287 | Centrosome maturation | 0.256614 | 0.591 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.317388 | 0.498 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.314732 | 0.502 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.326003 | 0.487 |
R-HSA-72086 | mRNA Capping | 0.338613 | 0.470 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.219595 | 0.658 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.313072 | 0.504 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.111328 | 0.953 |
R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.121759 | 0.915 |
R-HSA-190873 | Gap junction degradation | 0.132067 | 0.879 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.132067 | 0.879 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.219595 | 0.658 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.322786 | 0.491 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.282720 | 0.549 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.234891 | 0.629 |
R-HSA-373752 | Netrin-1 signaling | 0.126175 | 0.899 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.346388 | 0.460 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.314732 | 0.502 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.331331 | 0.480 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.221909 | 0.654 |
R-HSA-391251 | Protein folding | 0.338871 | 0.470 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.121759 | 0.915 |
R-HSA-196025 | Formation of annular gap junctions | 0.121759 | 0.915 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.142256 | 0.847 |
R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.152325 | 0.817 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.181834 | 0.740 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.237820 | 0.624 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.106968 | 0.971 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.289993 | 0.538 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.230558 | 0.637 |
R-HSA-201451 | Signaling by BMP | 0.322786 | 0.491 |
R-HSA-3928664 | Ephrin signaling | 0.237820 | 0.624 |
R-HSA-9843745 | Adipogenesis | 0.097518 | 1.011 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.338613 | 0.470 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.285763 | 0.544 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.162508 | 0.789 |
R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.132067 | 0.879 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.099528 | 1.002 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.281551 | 0.550 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.298337 | 0.525 |
R-HSA-3214815 | HDACs deacetylate histones | 0.170823 | 0.767 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.179207 | 0.747 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.328120 | 0.484 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.243571 | 0.613 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.106968 | 0.971 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.106968 | 0.971 |
R-HSA-480985 | Synthesis of dolichyl-phosphate-glucose | 0.100774 | 0.997 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.132067 | 0.879 |
R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.162277 | 0.790 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.191441 | 0.718 |
R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 0.219595 | 0.658 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.237820 | 0.624 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.330746 | 0.481 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.346388 | 0.460 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.295752 | 0.529 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.295752 | 0.529 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.142079 | 0.847 |
R-HSA-4641265 | Repression of WNT target genes | 0.172113 | 0.764 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.088661 | 1.052 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.200421 | 0.698 |
R-HSA-5334118 | DNA methylation | 0.338613 | 0.470 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.239229 | 0.621 |
R-HSA-73894 | DNA Repair | 0.164535 | 0.784 |
R-HSA-9834899 | Specification of the neural plate border | 0.246773 | 0.608 |
R-HSA-9605308 | Diseases of Base Excision Repair | 0.090096 | 1.045 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.243571 | 0.613 |
R-HSA-5617833 | Cilium Assembly | 0.234435 | 0.630 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.142256 | 0.847 |
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.246773 | 0.608 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.252264 | 0.598 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.169472 | 0.771 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.269669 | 0.569 |
R-HSA-68875 | Mitotic Prophase | 0.211309 | 0.675 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.183423 | 0.737 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.217594 | 0.662 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.167260 | 0.777 |
R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.246773 | 0.608 |
R-HSA-69481 | G2/M Checkpoints | 0.235934 | 0.627 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.090096 | 1.045 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.111328 | 0.953 |
R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.152325 | 0.817 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.172113 | 0.764 |
R-HSA-9005895 | Pervasive developmental disorders | 0.172113 | 0.764 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.172113 | 0.764 |
R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.228761 | 0.641 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.228761 | 0.641 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.306582 | 0.513 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.191896 | 0.717 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.330746 | 0.481 |
R-HSA-2132295 | MHC class II antigen presentation | 0.220478 | 0.657 |
R-HSA-68882 | Mitotic Anaphase | 0.148534 | 0.828 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.150365 | 0.823 |
R-HSA-69242 | S Phase | 0.312070 | 0.506 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.239229 | 0.621 |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.172113 | 0.764 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.278371 | 0.555 |
R-HSA-9664873 | Pexophagy | 0.142256 | 0.847 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.181834 | 0.740 |
R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.289993 | 0.538 |
R-HSA-193648 | NRAGE signals death through JNK | 0.175007 | 0.757 |
R-HSA-525793 | Myogenesis | 0.314732 | 0.502 |
R-HSA-3295583 | TRP channels | 0.314732 | 0.502 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.264366 | 0.578 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.234891 | 0.629 |
R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.298337 | 0.525 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.210320 | 0.677 |
R-HSA-69236 | G1 Phase | 0.126175 | 0.899 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.126175 | 0.899 |
R-HSA-8876725 | Protein methylation | 0.200936 | 0.697 |
R-HSA-1483213 | Synthesis of PE | 0.322786 | 0.491 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.200936 | 0.697 |
R-HSA-9629569 | Protein hydroxylation | 0.255621 | 0.592 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.273009 | 0.564 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.308749 | 0.510 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.304421 | 0.517 |
R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.264366 | 0.578 |
R-HSA-877300 | Interferon gamma signaling | 0.158224 | 0.801 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.255621 | 0.592 |
R-HSA-5620971 | Pyroptosis | 0.330746 | 0.481 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.301692 | 0.520 |
R-HSA-8982491 | Glycogen metabolism | 0.106968 | 0.971 |
R-HSA-5688426 | Deubiquitination | 0.226217 | 0.645 |
R-HSA-373753 | Nephrin family interactions | 0.255621 | 0.592 |
R-HSA-9833110 | RSV-host interactions | 0.158441 | 0.800 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.317759 | 0.498 |
R-HSA-9823739 | Formation of the anterior neural plate | 0.200936 | 0.697 |
R-HSA-3000170 | Syndecan interactions | 0.289993 | 0.538 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.269669 | 0.569 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.210320 | 0.677 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.114552 | 0.941 |
R-HSA-9637687 | Suppression of phagosomal maturation | 0.314732 | 0.502 |
R-HSA-913531 | Interferon Signaling | 0.342668 | 0.465 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.146120 | 0.835 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.191896 | 0.717 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.191896 | 0.717 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.191896 | 0.717 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.191896 | 0.717 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.191896 | 0.717 |
R-HSA-1500931 | Cell-Cell communication | 0.207637 | 0.683 |
R-HSA-446728 | Cell junction organization | 0.276736 | 0.558 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.090424 | 1.044 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.308749 | 0.510 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.234891 | 0.629 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.217760 | 0.662 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.169820 | 0.770 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.139141 | 0.857 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.139141 | 0.857 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.139141 | 0.857 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.172701 | 0.763 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.134535 | 0.871 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.175597 | 0.755 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.208271 | 0.681 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.191896 | 0.717 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.175597 | 0.755 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.260965 | 0.583 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.208271 | 0.681 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.217412 | 0.663 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.161263 | 0.792 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.217412 | 0.663 |
R-HSA-166520 | Signaling by NTRKs | 0.134535 | 0.871 |
R-HSA-201556 | Signaling by ALK | 0.103229 | 0.986 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.184363 | 0.734 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.193243 | 0.714 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.333905 | 0.476 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.160451 | 0.795 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.273711 | 0.563 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.236954 | 0.625 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.354072 | 0.451 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.354072 | 0.451 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.354072 | 0.451 |
R-HSA-182971 | EGFR downregulation | 0.354072 | 0.451 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.360146 | 0.444 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.360146 | 0.444 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.360146 | 0.444 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.360146 | 0.444 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.361666 | 0.442 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.369171 | 0.433 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.369171 | 0.433 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.369171 | 0.433 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.369171 | 0.433 |
R-HSA-9930044 | Nuclear RNA decay | 0.369171 | 0.433 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.369171 | 0.433 |
R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.369171 | 0.433 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.369171 | 0.433 |
R-HSA-3214847 | HATs acetylate histones | 0.372792 | 0.429 |
R-HSA-9614085 | FOXO-mediated transcription | 0.372792 | 0.429 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.376589 | 0.424 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.376589 | 0.424 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.376589 | 0.424 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.376589 | 0.424 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.376589 | 0.424 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.383920 | 0.416 |
R-HSA-180746 | Nuclear import of Rev protein | 0.383920 | 0.416 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.383920 | 0.416 |
R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.383920 | 0.416 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.383920 | 0.416 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.385337 | 0.414 |
R-HSA-72306 | tRNA processing | 0.385686 | 0.414 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.391165 | 0.408 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.395192 | 0.403 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.395192 | 0.403 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.398325 | 0.400 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.398325 | 0.400 |
R-HSA-9682385 | FLT3 signaling in disease | 0.398325 | 0.400 |
R-HSA-74160 | Gene expression (Transcription) | 0.400908 | 0.397 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.405401 | 0.392 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.405401 | 0.392 |
R-HSA-196757 | Metabolism of folate and pterines | 0.405401 | 0.392 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.405401 | 0.392 |
R-HSA-418346 | Platelet homeostasis | 0.406000 | 0.391 |
R-HSA-211000 | Gene Silencing by RNA | 0.410094 | 0.387 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.412395 | 0.385 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.412395 | 0.385 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.419307 | 0.377 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.419307 | 0.377 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.419307 | 0.377 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.419307 | 0.377 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.419307 | 0.377 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.426138 | 0.370 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.426138 | 0.370 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.426138 | 0.370 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.426138 | 0.370 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.426138 | 0.370 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.426138 | 0.370 |
R-HSA-167169 | HIV Transcription Elongation | 0.426138 | 0.370 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.426138 | 0.370 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.426138 | 0.370 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.426583 | 0.370 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.430349 | 0.366 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.432889 | 0.364 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.432889 | 0.364 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.432889 | 0.364 |
R-HSA-9694548 | Maturation of spike protein | 0.432889 | 0.364 |
R-HSA-69275 | G2/M Transition | 0.435894 | 0.361 |
R-HSA-5683057 | MAPK family signaling cascades | 0.436133 | 0.360 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.438349 | 0.358 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.439561 | 0.357 |
R-HSA-167161 | HIV Transcription Initiation | 0.439561 | 0.357 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.439561 | 0.357 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.439561 | 0.357 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.442071 | 0.355 |
R-HSA-73928 | Depyrimidination | 0.446155 | 0.351 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.446155 | 0.351 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.446504 | 0.350 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.450233 | 0.347 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.450233 | 0.347 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.452672 | 0.344 |
R-HSA-9710421 | Defective pyroptosis | 0.452672 | 0.344 |
R-HSA-8854214 | TBC/RABGAPs | 0.452672 | 0.344 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 0.452672 | 0.344 |
R-HSA-9007101 | Rab regulation of trafficking | 0.458078 | 0.339 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.459112 | 0.338 |
R-HSA-190828 | Gap junction trafficking | 0.459112 | 0.338 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.459112 | 0.338 |
R-HSA-5693538 | Homology Directed Repair | 0.461976 | 0.335 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.465477 | 0.332 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.465477 | 0.332 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.465477 | 0.332 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.465477 | 0.332 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.466508 | 0.331 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.470441 | 0.327 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.471768 | 0.326 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.471768 | 0.326 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.471768 | 0.326 |
R-HSA-75153 | Apoptotic execution phase | 0.471768 | 0.326 |
R-HSA-437239 | Recycling pathway of L1 | 0.477985 | 0.321 |
R-HSA-1483191 | Synthesis of PC | 0.477985 | 0.321 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.484129 | 0.315 |
R-HSA-425410 | Metal ion SLC transporters | 0.484129 | 0.315 |
R-HSA-9031628 | NGF-stimulated transcription | 0.484129 | 0.315 |
R-HSA-162909 | Host Interactions of HIV factors | 0.485016 | 0.314 |
R-HSA-73893 | DNA Damage Bypass | 0.490201 | 0.310 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.490201 | 0.310 |
R-HSA-9766229 | Degradation of CDH1 | 0.490201 | 0.310 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.490201 | 0.310 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.490201 | 0.310 |
R-HSA-6798695 | Neutrophil degranulation | 0.496532 | 0.304 |
R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.502133 | 0.299 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.507994 | 0.294 |
R-HSA-72187 | mRNA 3'-end processing | 0.507994 | 0.294 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.507994 | 0.294 |
R-HSA-6794361 | Neurexins and neuroligins | 0.507994 | 0.294 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.507994 | 0.294 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.507994 | 0.294 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.513787 | 0.289 |
R-HSA-445355 | Smooth Muscle Contraction | 0.513787 | 0.289 |
R-HSA-1474165 | Reproduction | 0.514772 | 0.288 |
R-HSA-597592 | Post-translational protein modification | 0.517978 | 0.286 |
R-HSA-195721 | Signaling by WNT | 0.518216 | 0.285 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.518411 | 0.285 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.519468 | 0.284 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.519512 | 0.284 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.519512 | 0.284 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.519512 | 0.284 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.522032 | 0.282 |
R-HSA-9909396 | Circadian clock | 0.522032 | 0.282 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.530761 | 0.275 |
R-HSA-177929 | Signaling by EGFR | 0.530761 | 0.275 |
R-HSA-5578775 | Ion homeostasis | 0.530761 | 0.275 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.530761 | 0.275 |
R-HSA-5654736 | Signaling by FGFR1 | 0.530761 | 0.275 |
R-HSA-418990 | Adherens junctions interactions | 0.533924 | 0.273 |
R-HSA-1483166 | Synthesis of PA | 0.536287 | 0.271 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.536287 | 0.271 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.536287 | 0.271 |
R-HSA-6782135 | Dual incision in TC-NER | 0.541749 | 0.266 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.541749 | 0.266 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.547146 | 0.262 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.547146 | 0.262 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.547146 | 0.262 |
R-HSA-6807070 | PTEN Regulation | 0.550344 | 0.259 |
R-HSA-8873719 | RAB geranylgeranylation | 0.552480 | 0.258 |
R-HSA-983189 | Kinesins | 0.552480 | 0.258 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.552480 | 0.258 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.556689 | 0.254 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.557751 | 0.254 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.557751 | 0.254 |
R-HSA-162906 | HIV Infection | 0.558981 | 0.253 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.561716 | 0.250 |
R-HSA-1268020 | Mitochondrial protein import | 0.562961 | 0.250 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.562961 | 0.250 |
R-HSA-9707616 | Heme signaling | 0.562961 | 0.250 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.562961 | 0.250 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.562961 | 0.250 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.564054 | 0.249 |
R-HSA-6799198 | Complex I biogenesis | 0.568110 | 0.246 |
R-HSA-8848021 | Signaling by PTK6 | 0.568110 | 0.246 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.568110 | 0.246 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.568110 | 0.246 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.573198 | 0.242 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.573198 | 0.242 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.580770 | 0.236 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.583197 | 0.234 |
R-HSA-9758941 | Gastrulation | 0.587324 | 0.231 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.588109 | 0.231 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.588109 | 0.231 |
R-HSA-212436 | Generic Transcription Pathway | 0.590113 | 0.229 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.590572 | 0.229 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.590572 | 0.229 |
R-HSA-167172 | Transcription of the HIV genome | 0.592963 | 0.227 |
R-HSA-5218859 | Regulated Necrosis | 0.592963 | 0.227 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.597012 | 0.224 |
R-HSA-69306 | DNA Replication | 0.600204 | 0.222 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.602500 | 0.220 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.603377 | 0.219 |
R-HSA-1989781 | PPARA activates gene expression | 0.606531 | 0.217 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.607186 | 0.217 |
R-HSA-1280218 | Adaptive Immune System | 0.609819 | 0.215 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.611816 | 0.213 |
R-HSA-74259 | Purine catabolism | 0.611816 | 0.213 |
R-HSA-162587 | HIV Life Cycle | 0.612782 | 0.213 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.612782 | 0.213 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.612782 | 0.213 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.615879 | 0.211 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.616392 | 0.210 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.616392 | 0.210 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.620914 | 0.207 |
R-HSA-421270 | Cell-cell junction organization | 0.621706 | 0.206 |
R-HSA-9006936 | Signaling by TGFB family members | 0.622016 | 0.206 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.625384 | 0.204 |
R-HSA-8852135 | Protein ubiquitination | 0.625384 | 0.204 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.625384 | 0.204 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.625384 | 0.204 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.625384 | 0.204 |
R-HSA-5689603 | UCH proteinases | 0.629801 | 0.201 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.634166 | 0.198 |
R-HSA-9694635 | Translation of Structural Proteins | 0.634166 | 0.198 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.635226 | 0.197 |
R-HSA-4086400 | PCP/CE pathway | 0.638480 | 0.195 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.642743 | 0.192 |
R-HSA-9833482 | PKR-mediated signaling | 0.646956 | 0.189 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.655235 | 0.184 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.657263 | 0.182 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.660079 | 0.180 |
R-HSA-5689880 | Ub-specific processing proteases | 0.662877 | 0.179 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.663321 | 0.178 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.667293 | 0.176 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.675097 | 0.171 |
R-HSA-9679506 | SARS-CoV Infections | 0.676942 | 0.169 |
R-HSA-438064 | Post NMDA receptor activation events | 0.678931 | 0.168 |
R-HSA-156902 | Peptide chain elongation | 0.682719 | 0.166 |
R-HSA-9663891 | Selective autophagy | 0.682719 | 0.166 |
R-HSA-9645723 | Diseases of programmed cell death | 0.682719 | 0.166 |
R-HSA-73884 | Base Excision Repair | 0.690164 | 0.161 |
R-HSA-112310 | Neurotransmitter release cycle | 0.690164 | 0.161 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.701006 | 0.154 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.701006 | 0.154 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.701006 | 0.154 |
R-HSA-983712 | Ion channel transport | 0.705166 | 0.152 |
R-HSA-1474290 | Collagen formation | 0.708023 | 0.150 |
R-HSA-9824446 | Viral Infection Pathways | 0.708492 | 0.150 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.717449 | 0.144 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.718243 | 0.144 |
R-HSA-1483257 | Phospholipid metabolism | 0.720227 | 0.143 |
R-HSA-157579 | Telomere Maintenance | 0.721570 | 0.142 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.721570 | 0.142 |
R-HSA-9609690 | HCMV Early Events | 0.722241 | 0.141 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.724858 | 0.140 |
R-HSA-190236 | Signaling by FGFR | 0.724858 | 0.140 |
R-HSA-70171 | Glycolysis | 0.731319 | 0.136 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.731621 | 0.136 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.731621 | 0.136 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.736210 | 0.133 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.737628 | 0.132 |
R-HSA-1483255 | PI Metabolism | 0.737628 | 0.132 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.738479 | 0.132 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.738479 | 0.132 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.740727 | 0.130 |
R-HSA-72172 | mRNA Splicing | 0.742968 | 0.129 |
R-HSA-5357801 | Programmed Cell Death | 0.745188 | 0.128 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.746817 | 0.127 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.746817 | 0.127 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.749808 | 0.125 |
R-HSA-69239 | Synthesis of DNA | 0.755686 | 0.122 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.755686 | 0.122 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.755686 | 0.122 |
R-HSA-2672351 | Stimuli-sensing channels | 0.758573 | 0.120 |
R-HSA-397014 | Muscle contraction | 0.760273 | 0.119 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.760273 | 0.119 |
R-HSA-5419276 | Mitochondrial translation termination | 0.761426 | 0.118 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.761426 | 0.118 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.762364 | 0.118 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.769365 | 0.114 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.783076 | 0.106 |
R-HSA-373760 | L1CAM interactions | 0.785640 | 0.105 |
R-HSA-70326 | Glucose metabolism | 0.788175 | 0.103 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.795571 | 0.099 |
R-HSA-8953854 | Metabolism of RNA | 0.796028 | 0.099 |
R-HSA-73886 | Chromosome Maintenance | 0.798020 | 0.098 |
R-HSA-3371556 | Cellular response to heat stress | 0.798020 | 0.098 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.798020 | 0.098 |
R-HSA-199991 | Membrane Trafficking | 0.804647 | 0.094 |
R-HSA-6809371 | Formation of the cornified envelope | 0.805103 | 0.094 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.809688 | 0.092 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.809688 | 0.092 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.809688 | 0.092 |
R-HSA-194138 | Signaling by VEGF | 0.809688 | 0.092 |
R-HSA-157118 | Signaling by NOTCH | 0.813140 | 0.090 |
R-HSA-168249 | Innate Immune System | 0.813648 | 0.090 |
R-HSA-8956319 | Nucleotide catabolism | 0.818537 | 0.087 |
R-HSA-5576891 | Cardiac conduction | 0.824905 | 0.084 |
R-HSA-9609646 | HCMV Infection | 0.829355 | 0.081 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.836980 | 0.077 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.836980 | 0.077 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.838469 | 0.077 |
R-HSA-5368287 | Mitochondrial translation | 0.840819 | 0.075 |
R-HSA-109582 | Hemostasis | 0.841727 | 0.075 |
R-HSA-9675108 | Nervous system development | 0.842356 | 0.075 |
R-HSA-1632852 | Macroautophagy | 0.846408 | 0.072 |
R-HSA-9734767 | Developmental Cell Lineages | 0.848546 | 0.071 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.850025 | 0.071 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.851802 | 0.070 |
R-HSA-1266738 | Developmental Biology | 0.853062 | 0.069 |
R-HSA-9609507 | Protein localization | 0.868458 | 0.061 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.871558 | 0.060 |
R-HSA-9612973 | Autophagy | 0.873081 | 0.059 |
R-HSA-9610379 | HCMV Late Events | 0.874586 | 0.058 |
R-HSA-109581 | Apoptosis | 0.881848 | 0.055 |
R-HSA-162582 | Signal Transduction | 0.886651 | 0.052 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.887727 | 0.052 |
R-HSA-5619102 | SLC transporter disorders | 0.888693 | 0.051 |
R-HSA-392499 | Metabolism of proteins | 0.897368 | 0.047 |
R-HSA-611105 | Respiratory electron transport | 0.903552 | 0.044 |
R-HSA-422475 | Axon guidance | 0.903904 | 0.044 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.904535 | 0.044 |
R-HSA-168255 | Influenza Infection | 0.904697 | 0.043 |
R-HSA-2559583 | Cellular Senescence | 0.905829 | 0.043 |
R-HSA-3781865 | Diseases of glycosylation | 0.910223 | 0.041 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.914110 | 0.039 |
R-HSA-1643685 | Disease | 0.916732 | 0.038 |
R-HSA-1474244 | Extracellular matrix organization | 0.920511 | 0.036 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.921630 | 0.035 |
R-HSA-428157 | Sphingolipid metabolism | 0.926736 | 0.033 |
R-HSA-376176 | Signaling by ROBO receptors | 0.928468 | 0.032 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.928586 | 0.032 |
R-HSA-5653656 | Vesicle-mediated transport | 0.929394 | 0.032 |
R-HSA-6805567 | Keratinization | 0.931811 | 0.031 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.941906 | 0.026 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.942477 | 0.026 |
R-HSA-8951664 | Neddylation | 0.943020 | 0.025 |
R-HSA-5663205 | Infectious disease | 0.948827 | 0.023 |
R-HSA-15869 | Metabolism of nucleotides | 0.952395 | 0.021 |
R-HSA-8939211 | ESR-mediated signaling | 0.952963 | 0.021 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.954077 | 0.020 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.956043 | 0.020 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.958279 | 0.019 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.959028 | 0.018 |
R-HSA-416476 | G alpha (q) signalling events | 0.965981 | 0.015 |
R-HSA-168256 | Immune System | 0.969122 | 0.014 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.969832 | 0.013 |
R-HSA-72766 | Translation | 0.970377 | 0.013 |
R-HSA-112316 | Neuronal System | 0.980166 | 0.009 |
R-HSA-382551 | Transport of small molecules | 0.980219 | 0.009 |
R-HSA-449147 | Signaling by Interleukins | 0.983141 | 0.007 |
R-HSA-8957322 | Metabolism of steroids | 0.983475 | 0.007 |
R-HSA-388396 | GPCR downstream signalling | 0.985596 | 0.006 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.986539 | 0.006 |
R-HSA-372790 | Signaling by GPCR | 0.993205 | 0.003 |
R-HSA-418594 | G alpha (i) signalling events | 0.994014 | 0.003 |
R-HSA-556833 | Metabolism of lipids | 0.994081 | 0.003 |
R-HSA-5668914 | Diseases of metabolism | 0.995303 | 0.002 |
R-HSA-211859 | Biological oxidations | 0.998540 | 0.001 |
R-HSA-2262752 | Cellular responses to stress | 0.999688 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999839 | 0.000 |
R-HSA-8953897 | Cellular responses to stimuli | 0.999921 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999988 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
KIS |
0.875 | 0.798 | 1 | 0.795 |
CDK17 |
0.871 | 0.862 | 1 | 0.891 |
CDK18 |
0.870 | 0.841 | 1 | 0.866 |
CDK19 |
0.869 | 0.821 | 1 | 0.848 |
P38G |
0.866 | 0.870 | 1 | 0.896 |
CDK8 |
0.864 | 0.820 | 1 | 0.813 |
CDK3 |
0.864 | 0.754 | 1 | 0.885 |
JNK2 |
0.863 | 0.868 | 1 | 0.862 |
CDK16 |
0.862 | 0.825 | 1 | 0.880 |
HIPK2 |
0.862 | 0.771 | 1 | 0.837 |
P38D |
0.862 | 0.861 | 1 | 0.897 |
CDK1 |
0.862 | 0.815 | 1 | 0.842 |
CDK13 |
0.861 | 0.824 | 1 | 0.844 |
ERK1 |
0.860 | 0.828 | 1 | 0.847 |
CDK7 |
0.859 | 0.805 | 1 | 0.822 |
DYRK2 |
0.857 | 0.767 | 1 | 0.754 |
CDK12 |
0.856 | 0.819 | 1 | 0.862 |
CDK14 |
0.855 | 0.821 | 1 | 0.833 |
P38B |
0.855 | 0.829 | 1 | 0.829 |
CDK5 |
0.854 | 0.780 | 1 | 0.796 |
DYRK4 |
0.853 | 0.778 | 1 | 0.847 |
JNK3 |
0.853 | 0.851 | 1 | 0.836 |
CDK9 |
0.852 | 0.811 | 1 | 0.839 |
DYRK1B |
0.851 | 0.752 | 1 | 0.817 |
ERK2 |
0.849 | 0.830 | 1 | 0.800 |
CDK10 |
0.846 | 0.756 | 1 | 0.849 |
P38A |
0.846 | 0.797 | 1 | 0.767 |
HIPK1 |
0.843 | 0.699 | 1 | 0.741 |
CDK4 |
0.841 | 0.803 | 1 | 0.869 |
CLK3 |
0.841 | 0.488 | 1 | 0.532 |
NLK |
0.841 | 0.723 | 1 | 0.565 |
CDK6 |
0.840 | 0.779 | 1 | 0.852 |
HIPK4 |
0.839 | 0.489 | 1 | 0.548 |
CDK2 |
0.838 | 0.645 | 1 | 0.723 |
DYRK1A |
0.838 | 0.617 | 1 | 0.728 |
HIPK3 |
0.837 | 0.686 | 1 | 0.717 |
JNK1 |
0.833 | 0.764 | 1 | 0.862 |
ERK5 |
0.833 | 0.413 | 1 | 0.479 |
CLK1 |
0.830 | 0.437 | -3 | 0.699 |
SRPK1 |
0.830 | 0.327 | -3 | 0.692 |
DYRK3 |
0.829 | 0.565 | 1 | 0.701 |
CLK4 |
0.826 | 0.410 | -3 | 0.721 |
CLK2 |
0.821 | 0.412 | -3 | 0.703 |
SRPK2 |
0.818 | 0.258 | -3 | 0.621 |
ICK |
0.817 | 0.344 | -3 | 0.787 |
COT |
0.817 | -0.071 | 2 | 0.892 |
MTOR |
0.816 | 0.171 | 1 | 0.359 |
CDKL5 |
0.811 | 0.141 | -3 | 0.741 |
PRP4 |
0.810 | 0.458 | -3 | 0.693 |
TBK1 |
0.810 | -0.139 | 1 | 0.163 |
CDKL1 |
0.809 | 0.119 | -3 | 0.751 |
CDC7 |
0.808 | -0.106 | 1 | 0.186 |
PRKD1 |
0.807 | 0.026 | -3 | 0.763 |
MAK |
0.807 | 0.472 | -2 | 0.780 |
SRPK3 |
0.807 | 0.221 | -3 | 0.668 |
PRPK |
0.806 | -0.104 | -1 | 0.872 |
IKKB |
0.805 | -0.142 | -2 | 0.816 |
MOS |
0.805 | -0.038 | 1 | 0.233 |
IKKE |
0.805 | -0.151 | 1 | 0.160 |
GCN2 |
0.804 | -0.160 | 2 | 0.798 |
PRKD2 |
0.804 | 0.034 | -3 | 0.723 |
DSTYK |
0.803 | -0.116 | 2 | 0.873 |
CAMK1B |
0.803 | -0.022 | -3 | 0.821 |
PDHK4 |
0.803 | -0.144 | 1 | 0.244 |
RAF1 |
0.803 | -0.171 | 1 | 0.182 |
ULK2 |
0.801 | -0.181 | 2 | 0.810 |
PIM3 |
0.801 | -0.055 | -3 | 0.788 |
RIPK3 |
0.801 | -0.103 | 3 | 0.754 |
PKN3 |
0.801 | -0.048 | -3 | 0.782 |
ATR |
0.800 | -0.063 | 1 | 0.221 |
BMPR2 |
0.800 | -0.140 | -2 | 0.915 |
NEK6 |
0.800 | -0.075 | -2 | 0.878 |
NUAK2 |
0.800 | 0.002 | -3 | 0.803 |
PDHK1 |
0.800 | -0.145 | 1 | 0.222 |
MOK |
0.799 | 0.437 | 1 | 0.629 |
NDR2 |
0.799 | -0.046 | -3 | 0.795 |
WNK1 |
0.798 | -0.081 | -2 | 0.899 |
NIK |
0.798 | -0.054 | -3 | 0.842 |
CHAK2 |
0.798 | -0.054 | -1 | 0.885 |
NEK7 |
0.797 | -0.149 | -3 | 0.826 |
MST4 |
0.797 | -0.054 | 2 | 0.836 |
CAMK2G |
0.797 | -0.097 | 2 | 0.777 |
TGFBR2 |
0.797 | -0.073 | -2 | 0.851 |
ERK7 |
0.796 | 0.258 | 2 | 0.539 |
CAMLCK |
0.796 | -0.001 | -2 | 0.903 |
ULK1 |
0.795 | -0.150 | -3 | 0.791 |
SKMLCK |
0.795 | -0.046 | -2 | 0.900 |
PIM1 |
0.795 | 0.010 | -3 | 0.739 |
IKKA |
0.795 | -0.084 | -2 | 0.796 |
MAPKAPK3 |
0.795 | -0.048 | -3 | 0.729 |
NDR1 |
0.794 | -0.064 | -3 | 0.789 |
HUNK |
0.794 | -0.143 | 2 | 0.813 |
RSK2 |
0.793 | -0.021 | -3 | 0.723 |
PAK6 |
0.793 | 0.039 | -2 | 0.784 |
BCKDK |
0.793 | -0.120 | -1 | 0.842 |
AMPKA1 |
0.793 | -0.071 | -3 | 0.811 |
DAPK2 |
0.792 | -0.036 | -3 | 0.826 |
PKCD |
0.792 | -0.040 | 2 | 0.795 |
MLK1 |
0.792 | -0.159 | 2 | 0.817 |
GRK1 |
0.792 | -0.036 | -2 | 0.824 |
P90RSK |
0.792 | -0.028 | -3 | 0.721 |
GRK5 |
0.791 | -0.136 | -3 | 0.827 |
P70S6KB |
0.791 | -0.018 | -3 | 0.753 |
PKN2 |
0.791 | -0.079 | -3 | 0.792 |
NEK9 |
0.791 | -0.161 | 2 | 0.854 |
MAPKAPK2 |
0.790 | -0.031 | -3 | 0.681 |
WNK3 |
0.790 | -0.196 | 1 | 0.180 |
AURC |
0.790 | 0.034 | -2 | 0.719 |
PINK1 |
0.789 | 0.185 | 1 | 0.395 |
NUAK1 |
0.789 | -0.028 | -3 | 0.754 |
LATS2 |
0.789 | -0.058 | -5 | 0.790 |
CAMK2D |
0.789 | -0.103 | -3 | 0.804 |
ALK4 |
0.789 | -0.016 | -2 | 0.887 |
GRK6 |
0.789 | -0.106 | 1 | 0.170 |
IRE1 |
0.789 | -0.106 | 1 | 0.178 |
MARK4 |
0.788 | -0.097 | 4 | 0.836 |
PRKD3 |
0.788 | -0.000 | -3 | 0.690 |
ATM |
0.788 | -0.071 | 1 | 0.185 |
AMPKA2 |
0.788 | -0.055 | -3 | 0.778 |
MLK2 |
0.788 | -0.134 | 2 | 0.838 |
CAMK4 |
0.788 | -0.084 | -3 | 0.788 |
ANKRD3 |
0.788 | -0.142 | 1 | 0.196 |
MELK |
0.788 | -0.067 | -3 | 0.763 |
TSSK2 |
0.787 | -0.079 | -5 | 0.869 |
MASTL |
0.787 | -0.185 | -2 | 0.864 |
TGFBR1 |
0.787 | -0.018 | -2 | 0.863 |
NIM1 |
0.787 | -0.104 | 3 | 0.757 |
PKACG |
0.787 | -0.035 | -2 | 0.787 |
RIPK1 |
0.786 | -0.183 | 1 | 0.169 |
MNK2 |
0.786 | -0.019 | -2 | 0.850 |
TSSK1 |
0.786 | -0.059 | -3 | 0.829 |
RSK3 |
0.786 | -0.048 | -3 | 0.711 |
PKR |
0.786 | -0.071 | 1 | 0.200 |
PLK1 |
0.785 | -0.109 | -2 | 0.851 |
PHKG1 |
0.785 | -0.072 | -3 | 0.785 |
DNAPK |
0.785 | -0.050 | 1 | 0.210 |
BMPR1B |
0.785 | -0.033 | 1 | 0.153 |
PAK3 |
0.784 | -0.056 | -2 | 0.839 |
LATS1 |
0.784 | -0.005 | -3 | 0.807 |
IRE2 |
0.784 | -0.098 | 2 | 0.782 |
DLK |
0.784 | -0.199 | 1 | 0.180 |
PAK1 |
0.784 | -0.037 | -2 | 0.835 |
NEK2 |
0.783 | -0.118 | 2 | 0.823 |
MLK3 |
0.782 | -0.096 | 2 | 0.738 |
MSK2 |
0.782 | -0.041 | -3 | 0.687 |
CHK1 |
0.782 | -0.028 | -3 | 0.789 |
YSK4 |
0.782 | -0.146 | 1 | 0.163 |
VRK2 |
0.781 | 0.005 | 1 | 0.278 |
AURB |
0.781 | 0.009 | -2 | 0.719 |
PKCZ |
0.781 | -0.057 | 2 | 0.798 |
MNK1 |
0.781 | -0.016 | -2 | 0.860 |
GRK7 |
0.780 | -0.023 | 1 | 0.202 |
GRK4 |
0.780 | -0.151 | -2 | 0.845 |
PKCA |
0.780 | -0.052 | 2 | 0.736 |
QIK |
0.779 | -0.112 | -3 | 0.803 |
QSK |
0.779 | -0.061 | 4 | 0.812 |
CAMK2B |
0.779 | -0.070 | 2 | 0.751 |
AKT2 |
0.779 | 0.017 | -3 | 0.643 |
PKCB |
0.778 | -0.065 | 2 | 0.747 |
PAK2 |
0.778 | -0.055 | -2 | 0.832 |
FAM20C |
0.778 | -0.023 | 2 | 0.585 |
GSK3A |
0.778 | 0.187 | 4 | 0.490 |
PKACB |
0.778 | 0.020 | -2 | 0.728 |
PKG2 |
0.778 | -0.008 | -2 | 0.722 |
MEK1 |
0.778 | -0.132 | 2 | 0.835 |
SMG1 |
0.777 | -0.094 | 1 | 0.205 |
CHAK1 |
0.777 | -0.150 | 2 | 0.781 |
ALK2 |
0.777 | -0.046 | -2 | 0.867 |
ACVR2A |
0.777 | -0.073 | -2 | 0.839 |
MYLK4 |
0.777 | -0.028 | -2 | 0.832 |
PKCG |
0.776 | -0.076 | 2 | 0.731 |
ACVR2B |
0.776 | -0.077 | -2 | 0.850 |
PIM2 |
0.776 | -0.002 | -3 | 0.701 |
CAMK2A |
0.776 | -0.051 | 2 | 0.740 |
PERK |
0.776 | -0.114 | -2 | 0.889 |
MAPKAPK5 |
0.776 | -0.087 | -3 | 0.673 |
TTBK2 |
0.776 | -0.214 | 2 | 0.711 |
HRI |
0.775 | -0.131 | -2 | 0.883 |
PKCH |
0.775 | -0.082 | 2 | 0.735 |
SIK |
0.774 | -0.071 | -3 | 0.719 |
MPSK1 |
0.774 | 0.008 | 1 | 0.259 |
SGK3 |
0.774 | -0.030 | -3 | 0.710 |
MLK4 |
0.774 | -0.130 | 2 | 0.732 |
RSK4 |
0.774 | -0.027 | -3 | 0.696 |
CAMK1G |
0.774 | -0.061 | -3 | 0.724 |
PLK3 |
0.774 | -0.119 | 2 | 0.742 |
MSK1 |
0.774 | -0.027 | -3 | 0.692 |
BRSK2 |
0.773 | -0.110 | -3 | 0.779 |
NEK5 |
0.772 | -0.121 | 1 | 0.181 |
IRAK4 |
0.772 | -0.127 | 1 | 0.163 |
PRKX |
0.772 | 0.028 | -3 | 0.639 |
BRAF |
0.771 | -0.107 | -4 | 0.830 |
PHKG2 |
0.771 | -0.077 | -3 | 0.759 |
BRSK1 |
0.771 | -0.094 | -3 | 0.746 |
SNRK |
0.771 | -0.159 | 2 | 0.705 |
BMPR1A |
0.771 | -0.038 | 1 | 0.142 |
MEKK1 |
0.771 | -0.152 | 1 | 0.186 |
PAK5 |
0.771 | -0.006 | -2 | 0.725 |
TLK2 |
0.770 | -0.135 | 1 | 0.158 |
AKT1 |
0.770 | 0.003 | -3 | 0.663 |
PLK4 |
0.770 | -0.147 | 2 | 0.656 |
WNK4 |
0.770 | -0.134 | -2 | 0.887 |
AURA |
0.770 | -0.007 | -2 | 0.695 |
ZAK |
0.769 | -0.156 | 1 | 0.160 |
MARK2 |
0.769 | -0.084 | 4 | 0.729 |
MEK5 |
0.769 | -0.168 | 2 | 0.832 |
MARK3 |
0.768 | -0.079 | 4 | 0.765 |
GRK2 |
0.768 | -0.090 | -2 | 0.737 |
MEKK3 |
0.768 | -0.169 | 1 | 0.180 |
DRAK1 |
0.768 | -0.164 | 1 | 0.148 |
SMMLCK |
0.768 | -0.029 | -3 | 0.774 |
PAK4 |
0.767 | 0.002 | -2 | 0.731 |
GSK3B |
0.767 | 0.048 | 4 | 0.481 |
PKCI |
0.767 | -0.037 | 2 | 0.754 |
DCAMKL1 |
0.767 | -0.073 | -3 | 0.738 |
TAO3 |
0.767 | -0.063 | 1 | 0.208 |
MST3 |
0.766 | -0.083 | 2 | 0.820 |
P70S6K |
0.766 | -0.051 | -3 | 0.661 |
PKCT |
0.766 | -0.076 | 2 | 0.753 |
DCAMKL2 |
0.766 | -0.067 | -3 | 0.770 |
MEKK2 |
0.766 | -0.142 | 2 | 0.824 |
GAK |
0.765 | -0.022 | 1 | 0.253 |
MARK1 |
0.764 | -0.105 | 4 | 0.790 |
SBK |
0.764 | 0.108 | -3 | 0.528 |
CAMK1D |
0.764 | -0.037 | -3 | 0.655 |
PKACA |
0.764 | 0.006 | -2 | 0.676 |
SSTK |
0.763 | -0.075 | 4 | 0.796 |
CK1E |
0.763 | -0.016 | -3 | 0.578 |
TLK1 |
0.762 | -0.137 | -2 | 0.851 |
NEK8 |
0.762 | -0.152 | 2 | 0.825 |
LKB1 |
0.762 | -0.051 | -3 | 0.814 |
TAO2 |
0.761 | -0.075 | 2 | 0.853 |
IRAK1 |
0.761 | -0.189 | -1 | 0.789 |
PKN1 |
0.760 | -0.050 | -3 | 0.682 |
PASK |
0.760 | -0.073 | -3 | 0.808 |
CAMKK1 |
0.760 | -0.156 | -2 | 0.840 |
CAMKK2 |
0.760 | -0.107 | -2 | 0.848 |
NEK11 |
0.760 | -0.155 | 1 | 0.203 |
NEK4 |
0.760 | -0.139 | 1 | 0.169 |
BUB1 |
0.759 | 0.051 | -5 | 0.833 |
CK1D |
0.759 | 0.013 | -3 | 0.533 |
PDK1 |
0.758 | -0.094 | 1 | 0.222 |
PKCE |
0.758 | -0.028 | 2 | 0.715 |
CK2A2 |
0.757 | -0.065 | 1 | 0.134 |
LOK |
0.757 | -0.063 | -2 | 0.831 |
HGK |
0.757 | -0.091 | 3 | 0.831 |
GCK |
0.756 | -0.096 | 1 | 0.195 |
TTBK1 |
0.756 | -0.171 | 2 | 0.621 |
PBK |
0.756 | -0.023 | 1 | 0.239 |
MST2 |
0.756 | -0.120 | 1 | 0.176 |
DAPK3 |
0.755 | -0.033 | -3 | 0.757 |
TNIK |
0.755 | -0.063 | 3 | 0.836 |
AKT3 |
0.755 | 0.003 | -3 | 0.573 |
CHK2 |
0.755 | -0.029 | -3 | 0.587 |
NEK1 |
0.754 | -0.132 | 1 | 0.164 |
MINK |
0.754 | -0.128 | 1 | 0.170 |
CAMK1A |
0.754 | -0.022 | -3 | 0.601 |
LRRK2 |
0.754 | -0.054 | 2 | 0.845 |
SLK |
0.754 | -0.050 | -2 | 0.776 |
RIPK2 |
0.753 | -0.175 | 1 | 0.150 |
SGK1 |
0.753 | 0.010 | -3 | 0.559 |
CK1A2 |
0.753 | -0.012 | -3 | 0.532 |
CK1G1 |
0.752 | -0.061 | -3 | 0.561 |
HPK1 |
0.752 | -0.097 | 1 | 0.196 |
GRK3 |
0.751 | -0.093 | -2 | 0.689 |
MAP3K15 |
0.751 | -0.148 | 1 | 0.177 |
MEKK6 |
0.751 | -0.144 | 1 | 0.181 |
EEF2K |
0.751 | -0.106 | 3 | 0.786 |
MRCKA |
0.751 | -0.017 | -3 | 0.715 |
MRCKB |
0.750 | -0.013 | -3 | 0.694 |
KHS1 |
0.750 | -0.074 | 1 | 0.188 |
CK2A1 |
0.749 | -0.071 | 1 | 0.125 |
DAPK1 |
0.749 | -0.041 | -3 | 0.738 |
TAK1 |
0.749 | -0.184 | 1 | 0.165 |
BIKE |
0.749 | -0.007 | 1 | 0.252 |
MST1 |
0.748 | -0.135 | 1 | 0.166 |
NEK3 |
0.748 | -0.103 | 1 | 0.185 |
KHS2 |
0.748 | -0.051 | 1 | 0.201 |
HASPIN |
0.747 | -0.006 | -1 | 0.696 |
ROCK2 |
0.747 | -0.023 | -3 | 0.740 |
VRK1 |
0.747 | -0.185 | 2 | 0.872 |
STK33 |
0.746 | -0.139 | 2 | 0.602 |
YSK1 |
0.745 | -0.134 | 2 | 0.818 |
PLK2 |
0.745 | -0.083 | -3 | 0.766 |
PKG1 |
0.743 | -0.030 | -2 | 0.644 |
DMPK1 |
0.743 | 0.019 | -3 | 0.718 |
PDHK3_TYR |
0.742 | 0.109 | 4 | 0.914 |
MEK2 |
0.741 | -0.204 | 2 | 0.831 |
AAK1 |
0.740 | 0.020 | 1 | 0.261 |
TTK |
0.739 | -0.072 | -2 | 0.857 |
ROCK1 |
0.737 | -0.024 | -3 | 0.707 |
TAO1 |
0.737 | -0.087 | 1 | 0.176 |
CRIK |
0.736 | -0.017 | -3 | 0.657 |
TESK1_TYR |
0.736 | 0.027 | 3 | 0.845 |
OSR1 |
0.735 | -0.089 | 2 | 0.815 |
LIMK2_TYR |
0.735 | 0.094 | -3 | 0.853 |
PDHK4_TYR |
0.734 | 0.047 | 2 | 0.855 |
MYO3B |
0.733 | -0.092 | 2 | 0.824 |
PKMYT1_TYR |
0.733 | 0.075 | 3 | 0.826 |
ASK1 |
0.731 | -0.150 | 1 | 0.176 |
MYO3A |
0.731 | -0.103 | 1 | 0.186 |
MAP2K4_TYR |
0.731 | -0.017 | -1 | 0.880 |
MAP2K7_TYR |
0.729 | -0.107 | 2 | 0.846 |
MAP2K6_TYR |
0.729 | 0.001 | -1 | 0.887 |
PINK1_TYR |
0.728 | -0.119 | 1 | 0.231 |
BMPR2_TYR |
0.727 | -0.005 | -1 | 0.886 |
PDHK1_TYR |
0.726 | -0.067 | -1 | 0.906 |
MST1R |
0.726 | -0.068 | 3 | 0.810 |
RET |
0.725 | -0.115 | 1 | 0.196 |
ALPHAK3 |
0.725 | -0.102 | -1 | 0.807 |
CSF1R |
0.724 | -0.065 | 3 | 0.809 |
LIMK1_TYR |
0.724 | -0.032 | 2 | 0.859 |
JAK2 |
0.723 | -0.102 | 1 | 0.204 |
TYK2 |
0.722 | -0.181 | 1 | 0.185 |
EPHA6 |
0.722 | -0.080 | -1 | 0.916 |
NEK10_TYR |
0.720 | -0.096 | 1 | 0.180 |
EPHB4 |
0.719 | -0.101 | -1 | 0.899 |
ROS1 |
0.719 | -0.139 | 3 | 0.759 |
STLK3 |
0.719 | -0.179 | 1 | 0.146 |
JAK3 |
0.718 | -0.099 | 1 | 0.182 |
ABL2 |
0.718 | -0.068 | -1 | 0.848 |
TYRO3 |
0.717 | -0.158 | 3 | 0.790 |
FGFR2 |
0.716 | -0.034 | 3 | 0.773 |
DDR1 |
0.716 | -0.124 | 4 | 0.810 |
YANK3 |
0.716 | -0.079 | 2 | 0.370 |
YES1 |
0.716 | -0.093 | -1 | 0.872 |
FGFR1 |
0.715 | -0.027 | 3 | 0.750 |
ABL1 |
0.715 | -0.069 | -1 | 0.844 |
INSRR |
0.715 | -0.110 | 3 | 0.739 |
JAK1 |
0.714 | -0.103 | 1 | 0.175 |
TNNI3K_TYR |
0.714 | -0.057 | 1 | 0.207 |
TEK |
0.714 | -0.018 | 3 | 0.730 |
KDR |
0.714 | -0.062 | 3 | 0.766 |
TNK1 |
0.713 | -0.079 | 3 | 0.775 |
KIT |
0.713 | -0.098 | 3 | 0.807 |
TXK |
0.713 | -0.093 | 1 | 0.150 |
CK1A |
0.712 | -0.046 | -3 | 0.447 |
HCK |
0.711 | -0.128 | -1 | 0.858 |
PDGFRB |
0.711 | -0.174 | 3 | 0.798 |
EPHA4 |
0.711 | -0.085 | 2 | 0.727 |
FLT3 |
0.710 | -0.145 | 3 | 0.786 |
LCK |
0.710 | -0.090 | -1 | 0.863 |
EPHB3 |
0.710 | -0.129 | -1 | 0.893 |
FGR |
0.710 | -0.171 | 1 | 0.175 |
TNK2 |
0.710 | -0.131 | 3 | 0.745 |
FER |
0.709 | -0.185 | 1 | 0.176 |
EPHB1 |
0.708 | -0.157 | 1 | 0.149 |
PDGFRA |
0.708 | -0.173 | 3 | 0.801 |
BLK |
0.707 | -0.081 | -1 | 0.865 |
EPHB2 |
0.707 | -0.126 | -1 | 0.887 |
AXL |
0.707 | -0.153 | 3 | 0.777 |
FGFR3 |
0.705 | -0.052 | 3 | 0.755 |
WEE1_TYR |
0.705 | -0.087 | -1 | 0.785 |
MERTK |
0.705 | -0.142 | 3 | 0.777 |
SRMS |
0.705 | -0.182 | 1 | 0.147 |
MET |
0.704 | -0.103 | 3 | 0.792 |
ITK |
0.703 | -0.166 | -1 | 0.835 |
FLT4 |
0.703 | -0.114 | 3 | 0.749 |
ERBB2 |
0.702 | -0.143 | 1 | 0.164 |
DDR2 |
0.702 | -0.044 | 3 | 0.721 |
FLT1 |
0.702 | -0.108 | -1 | 0.878 |
ALK |
0.701 | -0.156 | 3 | 0.707 |
TEC |
0.701 | -0.136 | -1 | 0.785 |
NTRK1 |
0.701 | -0.175 | -1 | 0.864 |
NTRK2 |
0.701 | -0.169 | 3 | 0.760 |
FYN |
0.700 | -0.085 | -1 | 0.839 |
EPHA7 |
0.700 | -0.127 | 2 | 0.746 |
INSR |
0.700 | -0.143 | 3 | 0.721 |
LTK |
0.700 | -0.160 | 3 | 0.732 |
EPHA1 |
0.698 | -0.143 | 3 | 0.772 |
FRK |
0.698 | -0.140 | -1 | 0.867 |
PTK2B |
0.698 | -0.082 | -1 | 0.831 |
NTRK3 |
0.697 | -0.133 | -1 | 0.819 |
EPHA3 |
0.697 | -0.131 | 2 | 0.713 |
BMX |
0.697 | -0.138 | -1 | 0.759 |
CK1G3 |
0.696 | -0.042 | -3 | 0.401 |
BTK |
0.696 | -0.224 | -1 | 0.798 |
MUSK |
0.696 | -0.112 | 1 | 0.125 |
PTK6 |
0.696 | -0.200 | -1 | 0.778 |
LYN |
0.695 | -0.129 | 3 | 0.719 |
EGFR |
0.695 | -0.104 | 1 | 0.130 |
EPHA5 |
0.694 | -0.118 | 2 | 0.723 |
EPHA8 |
0.693 | -0.110 | -1 | 0.869 |
SRC |
0.692 | -0.113 | -1 | 0.842 |
FGFR4 |
0.691 | -0.095 | -1 | 0.822 |
MATK |
0.691 | -0.105 | -1 | 0.786 |
PTK2 |
0.687 | -0.056 | -1 | 0.837 |
CSK |
0.686 | -0.158 | 2 | 0.750 |
SYK |
0.684 | -0.078 | -1 | 0.818 |
ERBB4 |
0.684 | -0.089 | 1 | 0.132 |
EPHA2 |
0.684 | -0.116 | -1 | 0.835 |
IGF1R |
0.683 | -0.137 | 3 | 0.663 |
YANK2 |
0.680 | -0.099 | 2 | 0.385 |
ZAP70 |
0.671 | -0.049 | -1 | 0.736 |
CK1G2 |
0.669 | -0.060 | -3 | 0.488 |
FES |
0.668 | -0.148 | -1 | 0.753 |