Motif 149 (n=140)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0A6YYK5 | None | S218 | ochoa | Uncharacterized protein | None |
A0A0C4DFX4 | None | S2824 | ochoa | Snf2 related CREBBP activator protein | None |
A0A1B0GVZ6 | MBD3L2B | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2B | None |
A0MZ66 | SHTN1 | S534 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
A5PKW4 | PSD | S133 | ochoa | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) | Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}. |
A6NE82 | MBD3L3 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) | None |
A6NF01 | POM121B | S542 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
A8CG34 | POM121C | S935 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
C9JVG2 | ZNF775 | S71 | ochoa | Zinc finger protein 775 | None |
O15061 | SYNM | S161 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15516 | CLOCK | S446 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
O60292 | SIPA1L3 | S317 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60353 | FZD6 | S653 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
O60759 | CYTIP | S222 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
O75676 | RPS6KA4 | S745 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
O94967 | WDR47 | S292 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
O95382 | MAP3K6 | S1129 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
P00519 | ABL1 | S659 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
P10588 | NR2F6 | S34 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
P12524 | MYCL | S38 | psp | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | None |
P14618 | PKM | S37 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
P15391 | CD19 | S499 | ochoa | B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) | Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}. |
P31937 | HIBADH | S88 | ochoa | 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) | None |
P32927 | CSF2RB | S665 | ochoa | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
P33241 | LSP1 | S111 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
P42679 | MATK | S26 | ochoa | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}. |
P42695 | NCAPD3 | S1419 | psp | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
P46531 | NOTCH1 | S2439 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
P49795 | RGS19 | S65 | ochoa | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
P60709 | ACTB | Y188 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
P62736 | ACTA2 | Y190 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
P63261 | ACTG1 | Y188 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
P63267 | ACTG2 | Y189 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
P68032 | ACTC1 | Y190 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
P68133 | ACTA1 | Y190 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
P78559 | MAP1A | S2171 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
P85037 | FOXK1 | S445 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
Q04725 | TLE2 | S193 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
Q07157 | TJP1 | S1025 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q07617 | SPAG1 | S581 | ochoa | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
Q13233 | MAP3K1 | S137 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
Q13370 | PDE3B | S22 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
Q13469 | NFATC2 | S73 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q13563 | PKD2 | S76 | ochoa|psp | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
Q13625 | TP53BP2 | Y869 | psp | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
Q14005 | IL16 | S177 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
Q14160 | SCRIB | S1475 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14676 | MDC1 | S1766 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14680 | MELK | S400 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
Q15697 | ZNF174 | S195 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
Q15772 | SPEG | S2037 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q15772 | SPEG | S2799 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q2M2I3 | FAM83E | S351 | ochoa | Protein FAM83E | May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}. |
Q3L8U1 | CHD9 | S2303 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
Q562R1 | ACTBL2 | Y189 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
Q676U5 | ATG16L1 | S278 | ochoa|psp | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
Q6P2E9 | EDC4 | S844 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6PJ61 | FBXO46 | S280 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
Q6UUV7 | CRTC3 | S172 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
Q6ZNH5 | ZNF497 | S98 | ochoa | Zinc finger protein 497 | May be involved in transcriptional regulation. |
Q6ZRS2 | SRCAP | S3001 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Q7L190 | DPPA4 | S221 | ochoa | Developmental pluripotency-associated protein 4 | May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. {ECO:0000250|UniProtKB:Q8CCG4}. |
Q7Z2K8 | GPRIN1 | S95 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z2Z1 | TICRR | S1115 | psp | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
Q7Z624 | CAMKMT | S20 | ochoa | Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) | Catalyzes the trimethylation of 'Lys-116' in calmodulin. {ECO:0000269|PubMed:20975703}. |
Q86TV6 | TTC7B | S678 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
Q86U86 | PBRM1 | S952 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q86UR5 | RIMS1 | S448 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
Q86UT5 | NHERF4 | S395 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. |
Q86VE9 | SERINC5 | S360 | psp | Serine incorporator 5 | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q63175, ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734, ECO:0000269|PubMed:37474505}. |
Q86WR7 | PROSER2 | S212 | ochoa | Proline and serine-rich protein 2 | None |
Q86X27 | RALGPS2 | S308 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
Q86X29 | LSR | S321 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
Q86X51 | EZHIP | S105 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
Q8IUG5 | MYO18B | S1216 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
Q8IX07 | ZFPM1 | S196 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Q8IXW5 | RPAP2 | S429 | ochoa | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}. |
Q8N612 | FHIP1B | S855 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
Q8N884 | CGAS | S37 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
Q8N884 | CGAS | S116 | ochoa|psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
Q8NEY8 | PPHLN1 | S244 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
Q8NHZ7 | MBD3L2 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2) | May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}. |
Q8TEK3 | DOT1L | S1083 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8TEK3 | DOT1L | S1213 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8WV41 | SNX33 | S146 | ochoa | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
Q8WVB6 | CHTF18 | S92 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
Q92766 | RREB1 | S1107 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
Q92793 | CREBBP | S78 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
Q92934 | BAD | S124 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
Q96BV0 | ZNF775 | S71 | ochoa | Zinc finger protein 775 | May be involved in transcriptional regulation. |
Q96DR7 | ARHGEF26 | S80 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
Q96FI4 | NEIL1 | S269 | psp | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}. |
Q96HA1 | POM121 | S958 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
Q96I34 | PPP1R16A | S478 | ochoa | Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) | Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}. |
Q96JN8 | NEURL4 | S502 | ochoa | Neuralized-like protein 4 | Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
Q99611 | SEPHS2 | S31 | ochoa | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}. |
Q99638 | RAD9A | S277 | ochoa|psp | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}. |
Q99958 | FOXC2 | S232 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
Q9BQA1 | WDR77 | S48 | ochoa | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. |
Q9BT81 | SOX7 | S166 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
Q9BTC0 | DIDO1 | S898 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BXK1 | KLF16 | S52 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
Q9BYJ9 | YTHDF1 | S350 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
Q9C0D5 | TANC1 | S280 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Q9H2K2 | TNKS2 | S666 | ochoa | Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}. |
Q9H4M7 | PLEKHA4 | S164 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
Q9H611 | PIF1 | S151 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
Q9H910 | JPT2 | S30 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
Q9H972 | C14orf93 | S224 | ochoa | Uncharacterized protein C14orf93 | None |
Q9HBD1 | RC3H2 | S549 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
Q9HC52 | CBX8 | S265 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
Q9HCE6 | ARHGEF10L | S138 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
Q9HCU4 | CELSR2 | S2665 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
Q9NP74 | PALMD | S253 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
Q9NQS7 | INCENP | S798 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
Q9NVZ3 | NECAP2 | S186 | ochoa | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | Involved in endocytosis. {ECO:0000250}. |
Q9NZ56 | FMN2 | S400 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
Q9NZ71 | RTEL1 | S791 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
Q9P227 | ARHGAP23 | S351 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Q9P243 | ZFAT | S652 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
Q9UBI9 | HECA | S272 | ochoa | Headcase protein homolog (hHDC) | May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. {ECO:0000303|PubMed:11696983}. |
Q9UDY2 | TJP2 | S266 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
Q9UF56 | FBXL17 | S303 | ochoa | F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) | Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}. |
Q9UHV7 | MED13 | S504 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
Q9ULL8 | SHROOM4 | S729 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
Q9UN79 | SOX13 | S371 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
Q9UNZ2 | NSFL1C | S140 | ochoa|psp | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
Q9UPQ9 | TNRC6B | S803 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
Q9UQ35 | SRRM2 | S297 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9UQ35 | SRRM2 | S2314 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2H6 | FNDC3A | S114 | ochoa | Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) | Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}. |
Q9Y3Q8 | TSC22D4 | S145 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
Q9Y3S1 | WNK2 | S49 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Q9Y4H2 | IRS2 | S770 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y5Y4 | PTGDR2 | S350 | ochoa | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
Q92974 | ARHGEF2 | S896 | GPS6|EPSD | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
Q96DV4 | MRPL38 | S129 | Sugiyama | Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38) | None |
Q8WYR1 | PIK3R5 | S446 | Sugiyama | Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}. |
P51813 | BMX | S369 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
Q9NQU5 | PAK6 | S202 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.000002 | 5.767 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.000041 | 4.392 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000085 | 4.071 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.000120 | 3.921 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.000153 | 3.815 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000264 | 3.579 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.000600 | 3.222 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000600 | 3.222 |
R-HSA-9707616 | Heme signaling | 0.000578 | 3.238 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.000524 | 3.280 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.000524 | 3.280 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.001082 | 2.966 |
R-HSA-437239 | Recycling pathway of L1 | 0.001947 | 2.711 |
R-HSA-418990 | Adherens junctions interactions | 0.002038 | 2.691 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.002749 | 2.561 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.002696 | 2.569 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.002749 | 2.561 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.003391 | 2.470 |
R-HSA-157118 | Signaling by NOTCH | 0.003480 | 2.458 |
R-HSA-193648 | NRAGE signals death through JNK | 0.003345 | 2.476 |
R-HSA-196025 | Formation of annular gap junctions | 0.005003 | 2.301 |
R-HSA-190873 | Gap junction degradation | 0.005917 | 2.228 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.005917 | 2.228 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.005003 | 2.301 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.005111 | 2.291 |
R-HSA-421270 | Cell-cell junction organization | 0.004449 | 2.352 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005805 | 2.236 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.007143 | 2.146 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.006965 | 2.157 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.007592 | 2.120 |
R-HSA-446728 | Cell junction organization | 0.007707 | 2.113 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.007917 | 2.101 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.008650 | 2.063 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.009077 | 2.042 |
R-HSA-9616334 | Defective Base Excision Repair Associated with NEIL1 | 0.009395 | 2.027 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.010264 | 1.989 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.010264 | 1.989 |
R-HSA-195721 | Signaling by WNT | 0.011093 | 1.955 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.012832 | 1.892 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.012824 | 1.892 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.012832 | 1.892 |
R-HSA-9909396 | Circadian clock | 0.013667 | 1.864 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.014210 | 1.847 |
R-HSA-75153 | Apoptotic execution phase | 0.014940 | 1.826 |
R-HSA-1500931 | Cell-Cell communication | 0.014986 | 1.824 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.017148 | 1.766 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.015649 | 1.806 |
R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.017148 | 1.766 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.017218 | 1.764 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.017218 | 1.764 |
R-HSA-2028269 | Signaling by Hippo | 0.018706 | 1.728 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.020985 | 1.678 |
R-HSA-70171 | Glycolysis | 0.021604 | 1.665 |
R-HSA-8942233 | Intestinal infectious diseases | 0.027923 | 1.554 |
R-HSA-5545619 | XAV939 stabilizes AXIN | 0.027923 | 1.554 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.055071 | 1.259 |
R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.055071 | 1.259 |
R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.055071 | 1.259 |
R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.055071 | 1.259 |
R-HSA-74713 | IRS activation | 0.063952 | 1.194 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.063952 | 1.194 |
R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.072751 | 1.138 |
R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.072751 | 1.138 |
R-HSA-109703 | PKB-mediated events | 0.072751 | 1.138 |
R-HSA-165160 | PDE3B signalling | 0.072751 | 1.138 |
R-HSA-5340588 | Signaling by RNF43 mutants | 0.072751 | 1.138 |
R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.072751 | 1.138 |
R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.072751 | 1.138 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 0.081466 | 1.089 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.090101 | 1.045 |
R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.090101 | 1.045 |
R-HSA-112412 | SOS-mediated signalling | 0.090101 | 1.045 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.098655 | 1.006 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.107129 | 0.970 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.107129 | 0.970 |
R-HSA-9020958 | Interleukin-21 signaling | 0.107129 | 0.970 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.115524 | 0.937 |
R-HSA-390450 | Folding of actin by CCT/TriC | 0.115524 | 0.937 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.123840 | 0.907 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.037239 | 1.429 |
R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.140241 | 0.853 |
R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.140241 | 0.853 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.043747 | 1.359 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.043747 | 1.359 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.046003 | 1.337 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.048302 | 1.316 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.048302 | 1.316 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.164271 | 0.784 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.164271 | 0.784 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.164271 | 0.784 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.053021 | 1.276 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.053021 | 1.276 |
R-HSA-390522 | Striated Muscle Contraction | 0.055440 | 1.256 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.055440 | 1.256 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.060391 | 1.219 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.070723 | 1.150 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.073391 | 1.134 |
R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.202849 | 0.693 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.135614 | 0.868 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.135614 | 0.868 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.135614 | 0.868 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.135614 | 0.868 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.135614 | 0.868 |
R-HSA-1989781 | PPARA activates gene expression | 0.082376 | 1.084 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.045957 | 1.338 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.085059 | 1.070 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.053021 | 1.276 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.147172 | 0.832 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.147172 | 0.832 |
R-HSA-198203 | PI3K/AKT activation | 0.115524 | 0.937 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.151767 | 0.819 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.147172 | 0.832 |
R-HSA-191650 | Regulation of gap junction activity | 0.055071 | 1.259 |
R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.063952 | 1.194 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.178323 | 0.749 |
R-HSA-4641265 | Repression of WNT target genes | 0.140241 | 0.853 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.063952 | 1.194 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.156336 | 0.806 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.065488 | 1.184 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.078820 | 1.103 |
R-HSA-112399 | IRS-mediated signalling | 0.126123 | 0.899 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.138813 | 0.858 |
R-HSA-9839394 | TGFBR3 expression | 0.035160 | 1.454 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.136313 | 0.865 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.132432 | 0.878 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.041533 | 1.382 |
R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.132079 | 0.879 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.078820 | 1.103 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.092913 | 1.032 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.092913 | 1.032 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.092913 | 1.032 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.081535 | 1.089 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.195505 | 0.709 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.055071 | 1.259 |
R-HSA-8964540 | Alanine metabolism | 0.055071 | 1.259 |
R-HSA-9927354 | Co-stimulation by ICOS | 0.098655 | 1.006 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.029212 | 1.534 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.132079 | 0.879 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.039364 | 1.405 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.148326 | 0.829 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.065488 | 1.184 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.187635 | 0.727 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.026137 | 1.583 |
R-HSA-191859 | snRNP Assembly | 0.026137 | 1.583 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.195277 | 0.709 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.090038 | 1.046 |
R-HSA-109704 | PI3K Cascade | 0.104668 | 0.980 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.076366 | 1.117 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.158332 | 0.800 |
R-HSA-6807070 | PTEN Regulation | 0.183645 | 0.736 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.148506 | 0.828 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.077138 | 1.113 |
R-HSA-2428924 | IGF1R signaling cascade | 0.148506 | 0.828 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.140241 | 0.853 |
R-HSA-6802949 | Signaling by RAS mutants | 0.092913 | 1.032 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.098655 | 1.006 |
R-HSA-74749 | Signal attenuation | 0.115524 | 0.937 |
R-HSA-9824272 | Somitogenesis | 0.090038 | 1.046 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.151767 | 0.819 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.087191 | 1.060 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.090101 | 1.045 |
R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.098655 | 1.006 |
R-HSA-9761174 | Formation of intermediate mesoderm | 0.115524 | 0.937 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.053021 | 1.276 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.055440 | 1.256 |
R-HSA-180786 | Extension of Telomeres | 0.026137 | 1.583 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.028166 | 1.550 |
R-HSA-9708530 | Regulation of BACH1 activity | 0.172132 | 0.764 |
R-HSA-114452 | Activation of BH3-only proteins | 0.046003 | 1.337 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.161634 | 0.791 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.079735 | 1.098 |
R-HSA-8964046 | VLDL clearance | 0.090101 | 1.045 |
R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.115524 | 0.937 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.179920 | 0.745 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.195277 | 0.709 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.138813 | 0.858 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.030726 | 1.512 |
R-HSA-9711123 | Cellular response to chemical stress | 0.138111 | 0.860 |
R-HSA-157579 | Telomere Maintenance | 0.083291 | 1.079 |
R-HSA-9843745 | Adipogenesis | 0.162827 | 0.788 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.035160 | 1.454 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.035160 | 1.454 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.188365 | 0.725 |
R-HSA-73886 | Chromosome Maintenance | 0.136313 | 0.865 |
R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.140241 | 0.853 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.156336 | 0.806 |
R-HSA-180746 | Nuclear import of Rev protein | 0.057897 | 1.237 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.032245 | 1.492 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.179920 | 0.745 |
R-HSA-5689603 | UCH proteinases | 0.188461 | 0.725 |
R-HSA-3214847 | HATs acetylate histones | 0.086852 | 1.061 |
R-HSA-68875 | Mitotic Prophase | 0.134176 | 0.872 |
R-HSA-9605308 | Diseases of Base Excision Repair | 0.072751 | 1.138 |
R-HSA-9664407 | Parasite infection | 0.186001 | 0.730 |
R-HSA-9664417 | Leishmania phagocytosis | 0.186001 | 0.730 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.186001 | 0.730 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.107129 | 0.970 |
R-HSA-428540 | Activation of RAC1 | 0.132079 | 0.879 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.073391 | 1.134 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.073391 | 1.134 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.076090 | 1.119 |
R-HSA-445355 | Smooth Muscle Contraction | 0.113735 | 0.944 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.174963 | 0.757 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.181693 | 0.741 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.056952 | 1.244 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.039364 | 1.405 |
R-HSA-5693538 | Homology Directed Repair | 0.037226 | 1.429 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.025496 | 1.594 |
R-HSA-4086398 | Ca2+ pathway | 0.178323 | 0.749 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.092913 | 1.032 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.176626 | 0.753 |
R-HSA-4839726 | Chromatin organization | 0.043252 | 1.364 |
R-HSA-4086400 | PCP/CE pathway | 0.195263 | 0.709 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.063952 | 1.194 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.156336 | 0.806 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.164271 | 0.784 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.068089 | 1.167 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.195277 | 0.709 |
R-HSA-190828 | Gap junction trafficking | 0.087191 | 1.060 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.092913 | 1.032 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.174963 | 0.757 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.034289 | 1.465 |
R-HSA-451927 | Interleukin-2 family signaling | 0.073391 | 1.134 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.187635 | 0.727 |
R-HSA-449836 | Other interleukin signaling | 0.202849 | 0.693 |
R-HSA-9675135 | Diseases of DNA repair | 0.092913 | 1.032 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.048664 | 1.313 |
R-HSA-73894 | DNA Repair | 0.151756 | 0.819 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.070723 | 1.150 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.126123 | 0.899 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.129268 | 0.889 |
R-HSA-9659379 | Sensory processing of sound | 0.198676 | 0.702 |
R-HSA-397014 | Muscle contraction | 0.177506 | 0.751 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.148326 | 0.829 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.185072 | 0.733 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.122996 | 0.910 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.142028 | 0.848 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.161634 | 0.791 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.140623 | 0.852 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.046003 | 1.337 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.168275 | 0.774 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.178323 | 0.749 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.140623 | 0.852 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.050642 | 1.295 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.122996 | 0.910 |
R-HSA-9758941 | Gastrulation | 0.074584 | 1.127 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.029212 | 1.534 |
R-HSA-74160 | Gene expression (Transcription) | 0.033253 | 1.478 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.169218 | 0.772 |
R-HSA-391908 | Prostanoid ligand receptors | 0.123840 | 0.907 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.140241 | 0.853 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.046003 | 1.337 |
R-HSA-8876725 | Protein methylation | 0.164271 | 0.784 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.095814 | 1.019 |
R-HSA-373760 | L1CAM interactions | 0.035519 | 1.450 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.180157 | 0.744 |
R-HSA-162582 | Signal Transduction | 0.025179 | 1.599 |
R-HSA-2586552 | Signaling by Leptin | 0.115524 | 0.937 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.202849 | 0.693 |
R-HSA-212436 | Generic Transcription Pathway | 0.040131 | 1.397 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.148326 | 0.829 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.158303 | 0.801 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.053692 | 1.270 |
R-HSA-70268 | Pyruvate metabolism | 0.063332 | 1.198 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.037226 | 1.429 |
R-HSA-5683057 | MAPK family signaling cascades | 0.135373 | 0.868 |
R-HSA-1640170 | Cell Cycle | 0.044193 | 1.355 |
R-HSA-109581 | Apoptosis | 0.028736 | 1.542 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.158332 | 0.800 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.119888 | 0.921 |
R-HSA-70326 | Glucose metabolism | 0.036367 | 1.439 |
R-HSA-211000 | Gene Silencing by RNA | 0.103644 | 0.984 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.145259 | 0.838 |
R-HSA-3371556 | Cellular response to heat stress | 0.136313 | 0.865 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.048664 | 1.313 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.177437 | 0.751 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.110690 | 0.956 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.193117 | 0.714 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.098740 | 1.006 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.052869 | 1.277 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.185072 | 0.733 |
R-HSA-5357801 | Programmed Cell Death | 0.063177 | 1.199 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.168275 | 0.774 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.198676 | 0.702 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.068089 | 1.167 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.127836 | 0.893 |
R-HSA-1483255 | PI Metabolism | 0.092312 | 1.035 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.087191 | 1.060 |
R-HSA-186712 | Regulation of beta-cell development | 0.132432 | 0.878 |
R-HSA-73887 | Death Receptor Signaling | 0.081050 | 1.091 |
R-HSA-1474244 | Extracellular matrix organization | 0.116451 | 0.934 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.205524 | 0.687 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.207964 | 0.682 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.208958 | 0.680 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.210349 | 0.677 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.210349 | 0.677 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.210349 | 0.677 |
R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.210349 | 0.677 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.212397 | 0.673 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.217779 | 0.662 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.217779 | 0.662 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.219293 | 0.659 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.222215 | 0.653 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.224634 | 0.649 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.225140 | 0.648 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.225140 | 0.648 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.225140 | 0.648 |
R-HSA-977347 | Serine metabolism | 0.225140 | 0.648 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.232107 | 0.634 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.232432 | 0.634 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.232432 | 0.634 |
R-HSA-8964038 | LDL clearance | 0.232432 | 0.634 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.239656 | 0.620 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.239656 | 0.620 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.239656 | 0.620 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.239656 | 0.620 |
R-HSA-9830674 | Formation of the ureteric bud | 0.239656 | 0.620 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.239656 | 0.620 |
R-HSA-982772 | Growth hormone receptor signaling | 0.239656 | 0.620 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.246813 | 0.608 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.246813 | 0.608 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.246813 | 0.608 |
R-HSA-74752 | Signaling by Insulin receptor | 0.250515 | 0.601 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.250515 | 0.601 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.253902 | 0.595 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.253902 | 0.595 |
R-HSA-9620244 | Long-term potentiation | 0.253902 | 0.595 |
R-HSA-1266695 | Interleukin-7 signaling | 0.253902 | 0.595 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.260925 | 0.583 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.260925 | 0.583 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.260925 | 0.583 |
R-HSA-525793 | Myogenesis | 0.260925 | 0.583 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.260925 | 0.583 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.260962 | 0.583 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.267294 | 0.573 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.267883 | 0.572 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.267930 | 0.572 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.271414 | 0.566 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.274775 | 0.561 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.274923 | 0.561 |
R-HSA-2262752 | Cellular responses to stress | 0.276998 | 0.558 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.277471 | 0.557 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.281603 | 0.550 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.281603 | 0.550 |
R-HSA-422475 | Axon guidance | 0.287580 | 0.541 |
R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.288367 | 0.540 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.288367 | 0.540 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.288822 | 0.539 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.288822 | 0.539 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.288822 | 0.539 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.295068 | 0.530 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.295068 | 0.530 |
R-HSA-9833110 | RSV-host interactions | 0.299246 | 0.524 |
R-HSA-8953897 | Cellular responses to stimuli | 0.307757 | 0.512 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.308282 | 0.511 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.308282 | 0.511 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.308282 | 0.511 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.308282 | 0.511 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.308282 | 0.511 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.308282 | 0.511 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.309647 | 0.509 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.309647 | 0.509 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.313108 | 0.504 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.314796 | 0.502 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.314796 | 0.502 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.314796 | 0.502 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.321250 | 0.493 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.321250 | 0.493 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.321250 | 0.493 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.321250 | 0.493 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.321250 | 0.493 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.326911 | 0.486 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.327643 | 0.485 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.327643 | 0.485 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.327643 | 0.485 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.333976 | 0.476 |
R-HSA-8853659 | RET signaling | 0.333976 | 0.476 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.333976 | 0.476 |
R-HSA-4641257 | Degradation of AXIN | 0.340250 | 0.468 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.340250 | 0.468 |
R-HSA-9675108 | Nervous system development | 0.343370 | 0.464 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.344061 | 0.463 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.344061 | 0.463 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.346466 | 0.460 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.349332 | 0.457 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.352623 | 0.453 |
R-HSA-3371568 | Attenuation phase | 0.358722 | 0.445 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.364765 | 0.438 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.364765 | 0.438 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.364765 | 0.438 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.364765 | 0.438 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.370751 | 0.431 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.370751 | 0.431 |
R-HSA-162909 | Host Interactions of HIV factors | 0.374563 | 0.426 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.376680 | 0.424 |
R-HSA-73928 | Depyrimidination | 0.376680 | 0.424 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.376680 | 0.424 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.377496 | 0.423 |
R-HSA-194138 | Signaling by VEGF | 0.381266 | 0.419 |
R-HSA-69481 | G2/M Checkpoints | 0.387940 | 0.411 |
R-HSA-5683826 | Surfactant metabolism | 0.388374 | 0.411 |
R-HSA-69236 | G1 Phase | 0.388374 | 0.411 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.388374 | 0.411 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.388374 | 0.411 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.394139 | 0.404 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.394139 | 0.404 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.399850 | 0.398 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.399850 | 0.398 |
R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.399850 | 0.398 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.400050 | 0.398 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.411112 | 0.386 |
R-HSA-389356 | Co-stimulation by CD28 | 0.411112 | 0.386 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.424051 | 0.373 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.427281 | 0.369 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.427612 | 0.369 |
R-HSA-70895 | Branched-chain amino acid catabolism | 0.427612 | 0.369 |
R-HSA-2514856 | The phototransduction cascade | 0.427612 | 0.369 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.433009 | 0.364 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.438356 | 0.358 |
R-HSA-1221632 | Meiotic synapsis | 0.438356 | 0.358 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.438356 | 0.358 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.443652 | 0.353 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.446458 | 0.350 |
R-HSA-418597 | G alpha (z) signalling events | 0.448900 | 0.348 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.460920 | 0.336 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.464348 | 0.333 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.469401 | 0.328 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.471464 | 0.327 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.474406 | 0.324 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.474406 | 0.324 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.474406 | 0.324 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.474406 | 0.324 |
R-HSA-1227986 | Signaling by ERBB2 | 0.474406 | 0.324 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.479778 | 0.319 |
R-HSA-5688426 | Deubiquitination | 0.481802 | 0.317 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.483714 | 0.315 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.484194 | 0.315 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.486749 | 0.313 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.488962 | 0.311 |
R-HSA-9610379 | HCMV Late Events | 0.492787 | 0.307 |
R-HSA-162587 | HIV Life Cycle | 0.492787 | 0.307 |
R-HSA-1266738 | Developmental Biology | 0.495013 | 0.305 |
R-HSA-1234174 | Cellular response to hypoxia | 0.498740 | 0.302 |
R-HSA-9006936 | Signaling by TGFB family members | 0.501759 | 0.300 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.501759 | 0.300 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.503471 | 0.298 |
R-HSA-9830369 | Kidney development | 0.508157 | 0.294 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.521954 | 0.282 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.521954 | 0.282 |
R-HSA-5619102 | SLC transporter disorders | 0.522296 | 0.282 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.526468 | 0.279 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.526468 | 0.279 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.526468 | 0.279 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.526468 | 0.279 |
R-HSA-68886 | M Phase | 0.529420 | 0.276 |
R-HSA-72306 | tRNA processing | 0.533777 | 0.273 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.537678 | 0.269 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.539447 | 0.268 |
R-HSA-9658195 | Leishmania infection | 0.542182 | 0.266 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.542182 | 0.266 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.552671 | 0.258 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.556895 | 0.254 |
R-HSA-168255 | Influenza Infection | 0.558918 | 0.253 |
R-HSA-2559583 | Cellular Senescence | 0.561652 | 0.251 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.565227 | 0.248 |
R-HSA-1483257 | Phospholipid metabolism | 0.572989 | 0.242 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.581425 | 0.236 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.581425 | 0.236 |
R-HSA-1500620 | Meiosis | 0.585380 | 0.233 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.585380 | 0.233 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.589298 | 0.230 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.589298 | 0.230 |
R-HSA-372790 | Signaling by GPCR | 0.591281 | 0.228 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.593179 | 0.227 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.593179 | 0.227 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.597024 | 0.224 |
R-HSA-438064 | Post NMDA receptor activation events | 0.597024 | 0.224 |
R-HSA-9609690 | HCMV Early Events | 0.603748 | 0.219 |
R-HSA-112310 | Neurotransmitter release cycle | 0.608343 | 0.216 |
R-HSA-73884 | Base Excision Repair | 0.608343 | 0.216 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.608343 | 0.216 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.613787 | 0.212 |
R-HSA-391251 | Protein folding | 0.619346 | 0.208 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.619346 | 0.208 |
R-HSA-376176 | Signaling by ROBO receptors | 0.621189 | 0.207 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.622945 | 0.206 |
R-HSA-388396 | GPCR downstream signalling | 0.627638 | 0.202 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.637006 | 0.196 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.643840 | 0.191 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.643840 | 0.191 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.643840 | 0.191 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.643840 | 0.191 |
R-HSA-9614085 | FOXO-mediated transcription | 0.647209 | 0.189 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.650546 | 0.187 |
R-HSA-2408557 | Selenocysteine synthesis | 0.653852 | 0.185 |
R-HSA-68882 | Mitotic Anaphase | 0.654297 | 0.184 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.656572 | 0.183 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.657126 | 0.182 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.660325 | 0.180 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.660370 | 0.180 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.663584 | 0.178 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.663584 | 0.178 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.664785 | 0.177 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.666767 | 0.176 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.666767 | 0.176 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.669921 | 0.174 |
R-HSA-162906 | HIV Infection | 0.678672 | 0.168 |
R-HSA-2672351 | Stimuli-sensing channels | 0.679204 | 0.168 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.679204 | 0.168 |
R-HSA-5419276 | Mitochondrial translation termination | 0.682240 | 0.166 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.682240 | 0.166 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.682240 | 0.166 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.691179 | 0.160 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.694103 | 0.159 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.697000 | 0.157 |
R-HSA-8939211 | ESR-mediated signaling | 0.699609 | 0.155 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.702711 | 0.153 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.702711 | 0.153 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.716525 | 0.145 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.716525 | 0.145 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.716525 | 0.145 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.718223 | 0.144 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.719411 | 0.143 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.721870 | 0.142 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.724506 | 0.140 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.724506 | 0.140 |
R-HSA-9609646 | HCMV Infection | 0.725136 | 0.140 |
R-HSA-977606 | Regulation of Complement cascade | 0.732263 | 0.135 |
R-HSA-168249 | Innate Immune System | 0.736547 | 0.133 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.742269 | 0.129 |
R-HSA-9734767 | Developmental Cell Lineages | 0.748818 | 0.126 |
R-HSA-1474165 | Reproduction | 0.749529 | 0.125 |
R-HSA-5368287 | Mitochondrial translation | 0.770113 | 0.113 |
R-HSA-1632852 | Macroautophagy | 0.776594 | 0.110 |
R-HSA-166658 | Complement cascade | 0.786994 | 0.104 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.789016 | 0.103 |
R-HSA-2187338 | Visual phototransduction | 0.791018 | 0.102 |
R-HSA-166520 | Signaling by NTRKs | 0.793002 | 0.101 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.793002 | 0.101 |
R-HSA-9679506 | SARS-CoV Infections | 0.796215 | 0.099 |
R-HSA-9612973 | Autophagy | 0.808212 | 0.092 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.822311 | 0.085 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.822311 | 0.085 |
R-HSA-8953854 | Metabolism of RNA | 0.823412 | 0.084 |
R-HSA-418555 | G alpha (s) signalling events | 0.835381 | 0.078 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.836695 | 0.077 |
R-HSA-8957322 | Metabolism of steroids | 0.837892 | 0.077 |
R-HSA-5689880 | Ub-specific processing proteases | 0.838496 | 0.076 |
R-HSA-3781865 | Diseases of glycosylation | 0.854611 | 0.068 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.856947 | 0.067 |
R-HSA-69275 | G2/M Transition | 0.857365 | 0.067 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.860067 | 0.065 |
R-HSA-983712 | Ion channel transport | 0.861398 | 0.065 |
R-HSA-449147 | Signaling by Interleukins | 0.862647 | 0.064 |
R-HSA-5617833 | Cilium Assembly | 0.862717 | 0.064 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.864024 | 0.063 |
R-HSA-68877 | Mitotic Prometaphase | 0.866601 | 0.062 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.867870 | 0.062 |
R-HSA-428157 | Sphingolipid metabolism | 0.876430 | 0.057 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.878841 | 0.056 |
R-HSA-199991 | Membrane Trafficking | 0.880041 | 0.055 |
R-HSA-72172 | mRNA Splicing | 0.881071 | 0.055 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.889841 | 0.051 |
R-HSA-913531 | Interferon Signaling | 0.896740 | 0.047 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.906401 | 0.043 |
R-HSA-418594 | G alpha (i) signalling events | 0.914188 | 0.039 |
R-HSA-1643685 | Disease | 0.917946 | 0.037 |
R-HSA-5668914 | Diseases of metabolism | 0.926587 | 0.033 |
R-HSA-416476 | G alpha (q) signalling events | 0.933107 | 0.030 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.939237 | 0.027 |
R-HSA-1280218 | Adaptive Immune System | 0.941728 | 0.026 |
R-HSA-6798695 | Neutrophil degranulation | 0.942076 | 0.026 |
R-HSA-112316 | Neuronal System | 0.946940 | 0.024 |
R-HSA-109582 | Hemostasis | 0.948785 | 0.023 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.950387 | 0.022 |
R-HSA-5653656 | Vesicle-mediated transport | 0.956281 | 0.019 |
R-HSA-168256 | Immune System | 0.958727 | 0.018 |
R-HSA-597592 | Post-translational protein modification | 0.961634 | 0.017 |
R-HSA-556833 | Metabolism of lipids | 0.977469 | 0.010 |
R-HSA-500792 | GPCR ligand binding | 0.980280 | 0.009 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.980354 | 0.009 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.981101 | 0.008 |
R-HSA-5663205 | Infectious disease | 0.984469 | 0.007 |
R-HSA-9824446 | Viral Infection Pathways | 0.985811 | 0.006 |
R-HSA-72766 | Translation | 0.986541 | 0.006 |
R-HSA-392499 | Metabolism of proteins | 0.997397 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.999364 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999589 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999959 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.855 | 0.692 | 1 | 0.899 |
CDK19 |
0.852 | 0.685 | 1 | 0.901 |
DYRK2 |
0.851 | 0.684 | 1 | 0.884 |
CDK8 |
0.851 | 0.685 | 1 | 0.897 |
CLK3 |
0.850 | 0.516 | 1 | 0.732 |
HIPK4 |
0.849 | 0.533 | 1 | 0.779 |
KIS |
0.848 | 0.633 | 1 | 0.901 |
JNK2 |
0.846 | 0.734 | 1 | 0.916 |
CDK18 |
0.844 | 0.688 | 1 | 0.894 |
DYRK4 |
0.843 | 0.672 | 1 | 0.907 |
CDK7 |
0.841 | 0.662 | 1 | 0.900 |
P38G |
0.840 | 0.710 | 1 | 0.891 |
CDK1 |
0.840 | 0.677 | 1 | 0.884 |
CDK3 |
0.840 | 0.645 | 1 | 0.887 |
JNK3 |
0.840 | 0.717 | 1 | 0.911 |
HIPK1 |
0.839 | 0.641 | 1 | 0.881 |
CDK13 |
0.837 | 0.662 | 1 | 0.908 |
P38D |
0.837 | 0.701 | 1 | 0.910 |
ERK1 |
0.836 | 0.671 | 1 | 0.906 |
CDK17 |
0.835 | 0.683 | 1 | 0.885 |
CDK12 |
0.835 | 0.667 | 1 | 0.913 |
DYRK1B |
0.835 | 0.650 | 1 | 0.881 |
SRPK1 |
0.834 | 0.354 | -3 | 0.750 |
P38B |
0.833 | 0.676 | 1 | 0.893 |
CDK5 |
0.831 | 0.638 | 1 | 0.881 |
CDK9 |
0.829 | 0.649 | 1 | 0.910 |
NLK |
0.829 | 0.599 | 1 | 0.807 |
CLK2 |
0.828 | 0.422 | -3 | 0.737 |
DYRK1A |
0.828 | 0.551 | 1 | 0.878 |
CLK1 |
0.827 | 0.434 | -3 | 0.739 |
HIPK3 |
0.826 | 0.609 | 1 | 0.877 |
MTOR |
0.826 | 0.279 | 1 | 0.662 |
P38A |
0.825 | 0.648 | 1 | 0.879 |
CDK16 |
0.825 | 0.646 | 1 | 0.887 |
CLK4 |
0.823 | 0.389 | -3 | 0.753 |
DYRK3 |
0.823 | 0.508 | 1 | 0.862 |
SRPK2 |
0.822 | 0.290 | -3 | 0.683 |
JNK1 |
0.820 | 0.633 | 1 | 0.899 |
ERK2 |
0.820 | 0.640 | 1 | 0.895 |
CDK14 |
0.819 | 0.638 | 1 | 0.898 |
ICK |
0.819 | 0.353 | -3 | 0.816 |
CDK10 |
0.818 | 0.611 | 1 | 0.898 |
ERK5 |
0.816 | 0.316 | 1 | 0.707 |
PRKD1 |
0.816 | 0.124 | -3 | 0.809 |
COT |
0.816 | -0.014 | 2 | 0.801 |
CDK2 |
0.814 | 0.518 | 1 | 0.844 |
MAK |
0.813 | 0.467 | -2 | 0.731 |
CDKL5 |
0.813 | 0.191 | -3 | 0.787 |
CDK4 |
0.812 | 0.638 | 1 | 0.915 |
CDKL1 |
0.812 | 0.182 | -3 | 0.788 |
CDK6 |
0.810 | 0.617 | 1 | 0.904 |
PRKD2 |
0.810 | 0.114 | -3 | 0.764 |
CDC7 |
0.810 | -0.028 | 1 | 0.480 |
PRP4 |
0.809 | 0.450 | -3 | 0.769 |
NDR2 |
0.809 | 0.041 | -3 | 0.797 |
SRPK3 |
0.809 | 0.240 | -3 | 0.713 |
TBK1 |
0.808 | -0.045 | 1 | 0.530 |
PIM3 |
0.807 | 0.043 | -3 | 0.802 |
IKKB |
0.806 | -0.070 | -2 | 0.699 |
NEK6 |
0.805 | 0.025 | -2 | 0.793 |
IKKE |
0.805 | -0.055 | 1 | 0.531 |
RSK2 |
0.804 | 0.075 | -3 | 0.775 |
PRPK |
0.804 | -0.069 | -1 | 0.819 |
RAF1 |
0.804 | -0.066 | 1 | 0.547 |
MOS |
0.803 | 0.005 | 1 | 0.541 |
ATR |
0.803 | 0.002 | 1 | 0.558 |
CHAK2 |
0.802 | 0.047 | -1 | 0.844 |
DSTYK |
0.802 | -0.046 | 2 | 0.822 |
CAMK1B |
0.801 | 0.021 | -3 | 0.823 |
GCN2 |
0.801 | -0.129 | 2 | 0.733 |
MST4 |
0.801 | 0.029 | 2 | 0.799 |
PIM1 |
0.801 | 0.092 | -3 | 0.751 |
PDHK4 |
0.801 | -0.116 | 1 | 0.600 |
MOK |
0.801 | 0.438 | 1 | 0.800 |
PKN3 |
0.800 | 0.021 | -3 | 0.787 |
ULK2 |
0.800 | -0.106 | 2 | 0.723 |
NUAK2 |
0.799 | 0.058 | -3 | 0.801 |
WNK1 |
0.799 | -0.003 | -2 | 0.860 |
P90RSK |
0.799 | 0.061 | -3 | 0.780 |
LATS2 |
0.799 | 0.018 | -5 | 0.770 |
RSK3 |
0.799 | 0.057 | -3 | 0.764 |
PKCD |
0.799 | 0.045 | 2 | 0.728 |
IKKA |
0.799 | -0.016 | -2 | 0.693 |
MARK4 |
0.799 | 0.010 | 4 | 0.776 |
CAMK2D |
0.798 | 0.010 | -3 | 0.809 |
MAPKAPK2 |
0.798 | 0.059 | -3 | 0.723 |
SKMLCK |
0.798 | 0.016 | -2 | 0.829 |
PDHK1 |
0.798 | -0.096 | 1 | 0.598 |
CAMK2G |
0.798 | -0.058 | 2 | 0.763 |
NEK7 |
0.797 | -0.066 | -3 | 0.807 |
NDR1 |
0.797 | -0.003 | -3 | 0.796 |
MAPKAPK3 |
0.797 | 0.032 | -3 | 0.758 |
NIK |
0.796 | 0.007 | -3 | 0.825 |
AURC |
0.795 | 0.057 | -2 | 0.593 |
BMPR2 |
0.795 | -0.139 | -2 | 0.818 |
CAMLCK |
0.794 | 0.026 | -2 | 0.795 |
LATS1 |
0.794 | 0.093 | -3 | 0.820 |
PKACG |
0.794 | 0.018 | -2 | 0.668 |
P70S6KB |
0.793 | 0.049 | -3 | 0.776 |
AMPKA1 |
0.793 | -0.004 | -3 | 0.806 |
DAPK2 |
0.793 | 0.020 | -3 | 0.832 |
DNAPK |
0.792 | 0.038 | 1 | 0.558 |
TSSK1 |
0.792 | 0.021 | -3 | 0.826 |
GSK3A |
0.792 | 0.217 | 4 | 0.503 |
PKN2 |
0.791 | -0.017 | -3 | 0.787 |
PRKD3 |
0.791 | 0.065 | -3 | 0.740 |
AMPKA2 |
0.791 | 0.019 | -3 | 0.784 |
PKACB |
0.790 | 0.067 | -2 | 0.607 |
GRK7 |
0.790 | 0.057 | 1 | 0.482 |
CAMK2A |
0.790 | 0.040 | 2 | 0.746 |
ULK1 |
0.790 | -0.120 | -3 | 0.754 |
ERK7 |
0.790 | 0.230 | 2 | 0.516 |
TGFBR2 |
0.790 | -0.079 | -2 | 0.722 |
CAMK2B |
0.789 | 0.012 | 2 | 0.736 |
QSK |
0.789 | 0.034 | 4 | 0.748 |
NIM1 |
0.789 | -0.017 | 3 | 0.760 |
RSK4 |
0.789 | 0.070 | -3 | 0.742 |
PAK1 |
0.788 | -0.002 | -2 | 0.744 |
BCKDK |
0.788 | -0.121 | -1 | 0.757 |
GRK1 |
0.788 | -0.032 | -2 | 0.715 |
NEK9 |
0.788 | -0.096 | 2 | 0.771 |
SGK3 |
0.788 | 0.075 | -3 | 0.739 |
HUNK |
0.787 | -0.126 | 2 | 0.720 |
MSK2 |
0.787 | 0.011 | -3 | 0.734 |
PRKX |
0.787 | 0.083 | -3 | 0.672 |
PKCA |
0.786 | 0.025 | 2 | 0.671 |
PAK3 |
0.786 | -0.023 | -2 | 0.742 |
ATM |
0.786 | -0.038 | 1 | 0.503 |
GRK5 |
0.786 | -0.154 | -3 | 0.757 |
WNK3 |
0.786 | -0.168 | 1 | 0.543 |
AKT2 |
0.786 | 0.085 | -3 | 0.693 |
FAM20C |
0.786 | 0.043 | 2 | 0.624 |
MLK1 |
0.786 | -0.148 | 2 | 0.745 |
SIK |
0.785 | 0.028 | -3 | 0.742 |
PAK6 |
0.785 | 0.039 | -2 | 0.653 |
MNK2 |
0.785 | 0.001 | -2 | 0.747 |
TSSK2 |
0.785 | -0.037 | -5 | 0.798 |
PKCB |
0.785 | 0.005 | 2 | 0.680 |
MLK2 |
0.784 | -0.090 | 2 | 0.758 |
TLK2 |
0.784 | -0.023 | 1 | 0.512 |
RIPK3 |
0.784 | -0.151 | 3 | 0.698 |
MSK1 |
0.784 | 0.034 | -3 | 0.732 |
MLK3 |
0.784 | -0.046 | 2 | 0.687 |
NEK2 |
0.783 | -0.029 | 2 | 0.761 |
NUAK1 |
0.783 | 0.001 | -3 | 0.760 |
PINK1 |
0.783 | 0.146 | 1 | 0.662 |
PKCG |
0.783 | -0.008 | 2 | 0.678 |
PHKG1 |
0.782 | -0.025 | -3 | 0.791 |
PKR |
0.782 | -0.022 | 1 | 0.541 |
BMPR1B |
0.782 | -0.010 | 1 | 0.409 |
MELK |
0.782 | -0.022 | -3 | 0.781 |
SMG1 |
0.782 | -0.026 | 1 | 0.537 |
MNK1 |
0.782 | 0.010 | -2 | 0.749 |
MASTL |
0.782 | -0.189 | -2 | 0.761 |
ALK4 |
0.781 | -0.023 | -2 | 0.784 |
ANKRD3 |
0.781 | -0.129 | 1 | 0.560 |
TGFBR1 |
0.781 | -0.015 | -2 | 0.758 |
PKCZ |
0.781 | -0.015 | 2 | 0.723 |
AURB |
0.781 | 0.015 | -2 | 0.589 |
DCAMKL1 |
0.780 | 0.034 | -3 | 0.763 |
GRK6 |
0.780 | -0.122 | 1 | 0.492 |
VRK2 |
0.780 | 0.020 | 1 | 0.613 |
RIPK1 |
0.780 | -0.172 | 1 | 0.518 |
YSK4 |
0.780 | -0.084 | 1 | 0.517 |
DLK |
0.779 | -0.195 | 1 | 0.525 |
IRE1 |
0.779 | -0.109 | 1 | 0.499 |
TTBK2 |
0.779 | -0.163 | 2 | 0.667 |
BRSK1 |
0.778 | -0.017 | -3 | 0.764 |
PIM2 |
0.778 | 0.072 | -3 | 0.740 |
MARK3 |
0.778 | -0.004 | 4 | 0.699 |
QIK |
0.778 | -0.059 | -3 | 0.800 |
PKG2 |
0.777 | 0.008 | -2 | 0.604 |
AKT1 |
0.777 | 0.067 | -3 | 0.706 |
PAK2 |
0.777 | -0.045 | -2 | 0.722 |
MPSK1 |
0.777 | 0.079 | 1 | 0.539 |
MARK2 |
0.777 | -0.016 | 4 | 0.684 |
CHK1 |
0.776 | -0.020 | -3 | 0.784 |
GRK4 |
0.776 | -0.164 | -2 | 0.758 |
PKCH |
0.776 | -0.035 | 2 | 0.658 |
PLK1 |
0.776 | -0.113 | -2 | 0.716 |
AURA |
0.776 | -0.002 | -2 | 0.565 |
CAMK4 |
0.775 | -0.103 | -3 | 0.772 |
MAPKAPK5 |
0.775 | -0.031 | -3 | 0.713 |
GSK3B |
0.774 | 0.078 | 4 | 0.499 |
CHAK1 |
0.774 | -0.106 | 2 | 0.729 |
PKACA |
0.774 | 0.043 | -2 | 0.556 |
TAO3 |
0.774 | 0.025 | 1 | 0.546 |
BRSK2 |
0.774 | -0.058 | -3 | 0.780 |
MEK1 |
0.774 | -0.128 | 2 | 0.782 |
IRE2 |
0.773 | -0.106 | 2 | 0.693 |
WNK4 |
0.772 | -0.051 | -2 | 0.854 |
PLK3 |
0.772 | -0.096 | 2 | 0.715 |
NEK5 |
0.771 | -0.041 | 1 | 0.529 |
SGK1 |
0.771 | 0.105 | -3 | 0.622 |
MLK4 |
0.771 | -0.111 | 2 | 0.661 |
BRAF |
0.770 | -0.057 | -4 | 0.824 |
PKCT |
0.770 | -0.018 | 2 | 0.668 |
MYLK4 |
0.769 | -0.028 | -2 | 0.719 |
ALK2 |
0.769 | -0.058 | -2 | 0.747 |
P70S6K |
0.769 | 0.035 | -3 | 0.705 |
PLK4 |
0.769 | -0.102 | 2 | 0.561 |
MST3 |
0.769 | -0.019 | 2 | 0.778 |
AKT3 |
0.768 | 0.081 | -3 | 0.642 |
MARK1 |
0.768 | -0.051 | 4 | 0.713 |
MEKK1 |
0.768 | -0.114 | 1 | 0.544 |
TLK1 |
0.767 | -0.092 | -2 | 0.770 |
PASK |
0.767 | 0.003 | -3 | 0.814 |
ACVR2B |
0.767 | -0.092 | -2 | 0.734 |
DCAMKL2 |
0.767 | -0.015 | -3 | 0.787 |
SSTK |
0.766 | -0.025 | 4 | 0.731 |
PERK |
0.766 | -0.135 | -2 | 0.758 |
SBK |
0.766 | 0.149 | -3 | 0.597 |
ACVR2A |
0.766 | -0.102 | -2 | 0.720 |
PAK5 |
0.766 | -0.008 | -2 | 0.582 |
LKB1 |
0.765 | 0.025 | -3 | 0.792 |
MEKK2 |
0.765 | -0.094 | 2 | 0.740 |
PDK1 |
0.765 | 0.010 | 1 | 0.566 |
CAMK1G |
0.765 | -0.037 | -3 | 0.744 |
PKCI |
0.765 | -0.008 | 2 | 0.693 |
TNIK |
0.765 | 0.054 | 3 | 0.872 |
ZAK |
0.764 | -0.138 | 1 | 0.516 |
MEK5 |
0.764 | -0.165 | 2 | 0.760 |
PAK4 |
0.764 | 0.002 | -2 | 0.588 |
BUB1 |
0.764 | 0.095 | -5 | 0.780 |
SNRK |
0.763 | -0.154 | 2 | 0.625 |
BMPR1A |
0.763 | -0.040 | 1 | 0.390 |
HRI |
0.762 | -0.179 | -2 | 0.783 |
GCK |
0.762 | 0.007 | 1 | 0.542 |
PKCE |
0.762 | 0.017 | 2 | 0.664 |
HGK |
0.761 | 0.002 | 3 | 0.852 |
CAMK1D |
0.761 | 0.003 | -3 | 0.681 |
DRAK1 |
0.761 | -0.155 | 1 | 0.436 |
PDHK3_TYR |
0.761 | 0.208 | 4 | 0.836 |
KHS1 |
0.760 | 0.054 | 1 | 0.559 |
SMMLCK |
0.760 | -0.026 | -3 | 0.788 |
PHKG2 |
0.760 | -0.069 | -3 | 0.763 |
MEKK3 |
0.760 | -0.186 | 1 | 0.526 |
PKN1 |
0.759 | 0.008 | -3 | 0.723 |
CK1G1 |
0.759 | -0.073 | -3 | 0.421 |
TAO2 |
0.759 | -0.052 | 2 | 0.786 |
KHS2 |
0.759 | 0.063 | 1 | 0.567 |
IRAK4 |
0.759 | -0.132 | 1 | 0.503 |
GRK2 |
0.759 | -0.123 | -2 | 0.659 |
NEK4 |
0.758 | -0.062 | 1 | 0.535 |
MINK |
0.758 | -0.020 | 1 | 0.539 |
DAPK3 |
0.757 | 0.004 | -3 | 0.774 |
NEK8 |
0.757 | -0.122 | 2 | 0.753 |
GAK |
0.757 | -0.033 | 1 | 0.540 |
ROCK2 |
0.757 | 0.053 | -3 | 0.758 |
HPK1 |
0.757 | -0.001 | 1 | 0.550 |
CK1E |
0.756 | -0.074 | -3 | 0.432 |
LOK |
0.756 | -0.018 | -2 | 0.700 |
NEK11 |
0.756 | -0.119 | 1 | 0.553 |
MRCKA |
0.756 | 0.035 | -3 | 0.733 |
CAMKK2 |
0.755 | -0.102 | -2 | 0.671 |
MAP3K15 |
0.755 | -0.054 | 1 | 0.527 |
MST2 |
0.755 | -0.076 | 1 | 0.529 |
MRCKB |
0.755 | 0.039 | -3 | 0.719 |
MEKK6 |
0.754 | -0.066 | 1 | 0.522 |
CHK2 |
0.754 | 0.028 | -3 | 0.646 |
LRRK2 |
0.754 | -0.019 | 2 | 0.786 |
PBK |
0.754 | 0.013 | 1 | 0.495 |
NEK1 |
0.754 | -0.053 | 1 | 0.518 |
LIMK2_TYR |
0.753 | 0.167 | -3 | 0.841 |
SLK |
0.752 | -0.033 | -2 | 0.642 |
CAMKK1 |
0.752 | -0.172 | -2 | 0.670 |
CK2A2 |
0.751 | -0.021 | 1 | 0.365 |
DAPK1 |
0.751 | -0.004 | -3 | 0.758 |
HASPIN |
0.751 | 0.058 | -1 | 0.740 |
TTBK1 |
0.751 | -0.172 | 2 | 0.584 |
TAK1 |
0.751 | -0.095 | 1 | 0.529 |
CK1D |
0.750 | -0.052 | -3 | 0.376 |
MAP2K4_TYR |
0.750 | 0.082 | -1 | 0.844 |
CAMK1A |
0.749 | 0.010 | -3 | 0.656 |
CRIK |
0.749 | 0.092 | -3 | 0.706 |
TESK1_TYR |
0.749 | 0.034 | 3 | 0.872 |
PDHK4_TYR |
0.748 | 0.042 | 2 | 0.815 |
PKMYT1_TYR |
0.748 | 0.098 | 3 | 0.827 |
PLK2 |
0.747 | -0.057 | -3 | 0.715 |
EEF2K |
0.747 | -0.084 | 3 | 0.814 |
YSK1 |
0.747 | -0.060 | 2 | 0.751 |
MST1 |
0.747 | -0.091 | 1 | 0.528 |
NEK3 |
0.746 | -0.047 | 1 | 0.533 |
GRK3 |
0.744 | -0.123 | -2 | 0.618 |
MAP2K6_TYR |
0.744 | 0.001 | -1 | 0.832 |
STK33 |
0.744 | -0.116 | 2 | 0.563 |
MEK2 |
0.743 | -0.150 | 2 | 0.754 |
MAP2K7_TYR |
0.743 | -0.101 | 2 | 0.793 |
PDHK1_TYR |
0.743 | -0.022 | -1 | 0.832 |
CK1A2 |
0.743 | -0.080 | -3 | 0.377 |
VRK1 |
0.743 | -0.175 | 2 | 0.768 |
ROCK1 |
0.742 | 0.028 | -3 | 0.730 |
IRAK1 |
0.741 | -0.261 | -1 | 0.732 |
CK2A1 |
0.741 | -0.035 | 1 | 0.350 |
PKG1 |
0.741 | -0.022 | -2 | 0.531 |
DMPK1 |
0.740 | 0.039 | -3 | 0.737 |
BMPR2_TYR |
0.739 | -0.032 | -1 | 0.795 |
PINK1_TYR |
0.739 | -0.137 | 1 | 0.559 |
RET |
0.738 | -0.099 | 1 | 0.554 |
LIMK1_TYR |
0.737 | -0.035 | 2 | 0.792 |
OSR1 |
0.737 | -0.060 | 2 | 0.740 |
MYO3B |
0.737 | -0.026 | 2 | 0.778 |
TAO1 |
0.736 | -0.053 | 1 | 0.518 |
NEK10_TYR |
0.735 | -0.031 | 1 | 0.508 |
JAK2 |
0.734 | -0.094 | 1 | 0.565 |
ASK1 |
0.734 | -0.087 | 1 | 0.522 |
MST1R |
0.734 | -0.101 | 3 | 0.770 |
RIPK2 |
0.732 | -0.238 | 1 | 0.498 |
BIKE |
0.732 | -0.029 | 1 | 0.480 |
MYO3A |
0.732 | -0.055 | 1 | 0.541 |
TYK2 |
0.731 | -0.185 | 1 | 0.548 |
CSF1R |
0.730 | -0.102 | 3 | 0.748 |
ABL2 |
0.729 | -0.062 | -1 | 0.749 |
ROS1 |
0.729 | -0.131 | 3 | 0.733 |
TNNI3K_TYR |
0.729 | -0.028 | 1 | 0.557 |
JAK1 |
0.728 | -0.052 | 1 | 0.534 |
DDR1 |
0.727 | -0.163 | 4 | 0.751 |
TNK1 |
0.727 | -0.054 | 3 | 0.755 |
AAK1 |
0.726 | 0.019 | 1 | 0.434 |
TYRO3 |
0.726 | -0.176 | 3 | 0.770 |
TNK2 |
0.726 | -0.081 | 3 | 0.707 |
ABL1 |
0.726 | -0.076 | -1 | 0.747 |
EPHA6 |
0.725 | -0.118 | -1 | 0.770 |
EPHB4 |
0.725 | -0.127 | -1 | 0.769 |
TTK |
0.725 | -0.130 | -2 | 0.740 |
JAK3 |
0.724 | -0.143 | 1 | 0.526 |
ALPHAK3 |
0.722 | -0.095 | -1 | 0.731 |
FGFR2 |
0.722 | -0.099 | 3 | 0.738 |
YANK3 |
0.722 | -0.077 | 2 | 0.381 |
FGFR1 |
0.720 | -0.093 | 3 | 0.709 |
FGR |
0.719 | -0.187 | 1 | 0.493 |
YES1 |
0.719 | -0.146 | -1 | 0.785 |
TXK |
0.718 | -0.106 | 1 | 0.445 |
KIT |
0.717 | -0.156 | 3 | 0.742 |
PDGFRB |
0.717 | -0.217 | 3 | 0.758 |
KDR |
0.717 | -0.128 | 3 | 0.703 |
FLT3 |
0.717 | -0.180 | 3 | 0.756 |
INSRR |
0.717 | -0.171 | 3 | 0.696 |
EPHA4 |
0.717 | -0.116 | 2 | 0.713 |
PDGFRA |
0.714 | -0.206 | 3 | 0.763 |
FER |
0.714 | -0.238 | 1 | 0.497 |
LCK |
0.714 | -0.131 | -1 | 0.728 |
TEK |
0.714 | -0.104 | 3 | 0.689 |
AXL |
0.714 | -0.178 | 3 | 0.726 |
CK1A |
0.713 | -0.087 | -3 | 0.286 |
SRMS |
0.713 | -0.201 | 1 | 0.468 |
HCK |
0.712 | -0.193 | -1 | 0.735 |
DDR2 |
0.712 | -0.085 | 3 | 0.668 |
EPHB1 |
0.712 | -0.193 | 1 | 0.474 |
MERTK |
0.712 | -0.160 | 3 | 0.735 |
STLK3 |
0.712 | -0.191 | 1 | 0.497 |
ITK |
0.711 | -0.184 | -1 | 0.721 |
MET |
0.711 | -0.149 | 3 | 0.746 |
WEE1_TYR |
0.711 | -0.122 | -1 | 0.709 |
BLK |
0.711 | -0.117 | -1 | 0.736 |
EPHB3 |
0.711 | -0.177 | -1 | 0.741 |
EPHB2 |
0.710 | -0.170 | -1 | 0.742 |
PTK6 |
0.709 | -0.196 | -1 | 0.681 |
FGFR3 |
0.709 | -0.123 | 3 | 0.707 |
FLT1 |
0.708 | -0.156 | -1 | 0.757 |
ALK |
0.706 | -0.196 | 3 | 0.657 |
LTK |
0.705 | -0.194 | 3 | 0.679 |
ERBB2 |
0.705 | -0.193 | 1 | 0.496 |
NTRK1 |
0.705 | -0.236 | -1 | 0.757 |
TEC |
0.704 | -0.181 | -1 | 0.683 |
FGFR4 |
0.704 | -0.102 | -1 | 0.716 |
EGFR |
0.703 | -0.113 | 1 | 0.430 |
MATK |
0.703 | -0.129 | -1 | 0.689 |
BMX |
0.703 | -0.165 | -1 | 0.643 |
FLT4 |
0.703 | -0.194 | 3 | 0.695 |
EPHA7 |
0.702 | -0.163 | 2 | 0.711 |
BTK |
0.702 | -0.264 | -1 | 0.704 |
CSK |
0.702 | -0.149 | 2 | 0.717 |
NTRK3 |
0.702 | -0.167 | -1 | 0.705 |
INSR |
0.702 | -0.194 | 3 | 0.681 |
EPHA3 |
0.701 | -0.178 | 2 | 0.685 |
EPHA1 |
0.700 | -0.193 | 3 | 0.710 |
FYN |
0.700 | -0.149 | -1 | 0.693 |
NTRK2 |
0.700 | -0.246 | 3 | 0.699 |
FRK |
0.700 | -0.185 | -1 | 0.751 |
PTK2B |
0.699 | -0.140 | -1 | 0.720 |
LYN |
0.696 | -0.194 | 3 | 0.666 |
CK1G3 |
0.696 | -0.087 | -3 | 0.238 |
EPHA5 |
0.695 | -0.172 | 2 | 0.692 |
EPHA8 |
0.693 | -0.163 | -1 | 0.697 |
SRC |
0.692 | -0.184 | -1 | 0.711 |
PTK2 |
0.690 | -0.104 | -1 | 0.681 |
SYK |
0.689 | -0.124 | -1 | 0.665 |
IGF1R |
0.686 | -0.178 | 3 | 0.618 |
YANK2 |
0.685 | -0.108 | 2 | 0.396 |
EPHA2 |
0.685 | -0.157 | -1 | 0.675 |
MUSK |
0.685 | -0.188 | 1 | 0.412 |
ERBB4 |
0.684 | -0.128 | 1 | 0.416 |
ZAP70 |
0.677 | -0.084 | -1 | 0.594 |
CK1G2 |
0.668 | -0.112 | -3 | 0.332 |
FES |
0.663 | -0.226 | -1 | 0.629 |