Motif 149 (n=140)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0A6YYK5 None S218 ochoa Uncharacterized protein None
A0A0C4DFX4 None S2824 ochoa Snf2 related CREBBP activator protein None
A0A1B0GVZ6 MBD3L2B S137 ochoa Methyl-CpG-binding domain protein 3-like 2B None
A0MZ66 SHTN1 S534 ochoa Shootin-1 (Shootin1) Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.
A5PKW4 PSD S133 ochoa PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}.
A6NE82 MBD3L3 S137 ochoa Methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) None
A6NF01 POM121B S542 ochoa Putative nuclear envelope pore membrane protein POM 121B Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}.
A8CG34 POM121C S935 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
C9JVG2 ZNF775 S71 ochoa Zinc finger protein 775 None
O15061 SYNM S161 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15516 CLOCK S446 ochoa Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.
O60292 SIPA1L3 S317 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60353 FZD6 S653 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O60759 CYTIP S222 ochoa Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
O75676 RPS6KA4 S745 ochoa Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
O94967 WDR47 S292 ochoa WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) None
O95382 MAP3K6 S1129 ochoa Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.
P00519 ABL1 S659 ochoa Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P10588 NR2F6 S34 ochoa Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.
P12524 MYCL S38 psp Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) None
P14618 PKM S37 ochoa|psp Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P15391 CD19 S499 ochoa B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}.
P31937 HIBADH S88 ochoa 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) None
P32927 CSF2RB S665 ochoa Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}.
P33241 LSP1 S111 ochoa Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}.
P42679 MATK S26 ochoa Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}.
P42695 NCAPD3 S1419 psp Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P46531 NOTCH1 S2439 psp Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.
P49795 RGS19 S65 ochoa Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
P60709 ACTB Y188 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62736 ACTA2 Y190 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63261 ACTG1 Y188 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 Y189 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 Y190 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68133 ACTA1 Y190 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P78559 MAP1A S2171 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P85037 FOXK1 S445 ochoa Forkhead box protein K1 (Myocyte nuclear factor) (MNF) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}.
Q04725 TLE2 S193 ochoa Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
Q07157 TJP1 S1025 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q07617 SPAG1 S581 ochoa Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}.
Q13233 MAP3K1 S137 ochoa Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.
Q13370 PDE3B S22 ochoa cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}.
Q13469 NFATC2 S73 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13563 PKD2 S76 ochoa|psp Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}.
Q13625 TP53BP2 Y869 psp Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q14005 IL16 S177 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14160 SCRIB S1475 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14676 MDC1 S1766 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14680 MELK S400 ochoa Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}.
Q15697 ZNF174 S195 ochoa Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) Transcriptional repressor. {ECO:0000269|PubMed:7673192}.
Q15772 SPEG S2037 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15772 SPEG S2799 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q2M2I3 FAM83E S351 ochoa Protein FAM83E May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}.
Q3L8U1 CHD9 S2303 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q562R1 ACTBL2 Y189 ochoa Beta-actin-like protein 2 (Kappa-actin) Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.
Q676U5 ATG16L1 S278 ochoa|psp Autophagy-related protein 16-1 (APG16-like 1) Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}.
Q6P2E9 EDC4 S844 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6PJ61 FBXO46 S280 ochoa F-box only protein 46 (F-box only protein 34-like) Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
Q6UUV7 CRTC3 S172 ochoa CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
Q6ZNH5 ZNF497 S98 ochoa Zinc finger protein 497 May be involved in transcriptional regulation.
Q6ZRS2 SRCAP S3001 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q7L190 DPPA4 S221 ochoa Developmental pluripotency-associated protein 4 May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. {ECO:0000250|UniProtKB:Q8CCG4}.
Q7Z2K8 GPRIN1 S95 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z2Z1 TICRR S1115 psp Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z624 CAMKMT S20 ochoa Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) Catalyzes the trimethylation of 'Lys-116' in calmodulin. {ECO:0000269|PubMed:20975703}.
Q86TV6 TTC7B S678 ochoa Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}.
Q86U86 PBRM1 S952 ochoa Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q86UR5 RIMS1 S448 ochoa Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.
Q86UT5 NHERF4 S395 psp Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
Q86VE9 SERINC5 S360 psp Serine incorporator 5 Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q63175, ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734, ECO:0000269|PubMed:37474505}.
Q86WR7 PROSER2 S212 ochoa Proline and serine-rich protein 2 None
Q86X27 RALGPS2 S308 ochoa Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q86X29 LSR S321 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q86X51 EZHIP S105 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q8IUG5 MYO18B S1216 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IX07 ZFPM1 S196 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IXW5 RPAP2 S429 ochoa Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}.
Q8N612 FHIP1B S855 ochoa FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.
Q8N884 CGAS S37 psp Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}.
Q8N884 CGAS S116 ochoa|psp Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}.
Q8NEY8 PPHLN1 S244 ochoa Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}.
Q8NHZ7 MBD3L2 S137 ochoa Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2) May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}.
Q8TEK3 DOT1L S1083 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8TEK3 DOT1L S1213 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8WV41 SNX33 S146 ochoa Sorting nexin-33 (SH3 and PX domain-containing protein 3) Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
Q8WVB6 CHTF18 S92 ochoa Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}.
Q92766 RREB1 S1107 ochoa Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.
Q92793 CREBBP S78 psp CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q92934 BAD S124 ochoa|psp Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
Q96BV0 ZNF775 S71 ochoa Zinc finger protein 775 May be involved in transcriptional regulation.
Q96DR7 ARHGEF26 S80 ochoa Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
Q96FI4 NEIL1 S269 psp Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
Q96HA1 POM121 S958 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96I34 PPP1R16A S478 ochoa Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}.
Q96JN8 NEURL4 S502 ochoa Neuralized-like protein 4 Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}.
Q99611 SEPHS2 S31 ochoa Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}.
Q99638 RAD9A S277 ochoa|psp Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}.
Q99958 FOXC2 S232 ochoa|psp Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) Transcriptional activator. {ECO:0000269|PubMed:9169153}.
Q9BQA1 WDR77 S48 ochoa Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.
Q9BT81 SOX7 S166 ochoa Transcription factor SOX-7 Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}.
Q9BTC0 DIDO1 S898 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BXK1 KLF16 S52 ochoa Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}.
Q9BYJ9 YTHDF1 S350 ochoa YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}.
Q9C0D5 TANC1 S280 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H2K2 TNKS2 S666 ochoa Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}.
Q9H4M7 PLEKHA4 S164 ochoa Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}.
Q9H611 PIF1 S151 ochoa ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}.
Q9H910 JPT2 S30 ochoa Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}.
Q9H972 C14orf93 S224 ochoa Uncharacterized protein C14orf93 None
Q9HBD1 RC3H2 S549 ochoa Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}.
Q9HC52 CBX8 S265 ochoa Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.
Q9HCE6 ARHGEF10L S138 ochoa Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}.
Q9HCU4 CELSR2 S2665 ochoa Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9NP74 PALMD S253 ochoa Palmdelphin (Paralemmin-like protein) None
Q9NQS7 INCENP S798 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NVZ3 NECAP2 S186 ochoa Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) Involved in endocytosis. {ECO:0000250}.
Q9NZ56 FMN2 S400 ochoa Formin-2 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.
Q9NZ71 RTEL1 S791 ochoa Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}.
Q9P227 ARHGAP23 S351 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P243 ZFAT S652 ochoa Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
Q9UBI9 HECA S272 ochoa Headcase protein homolog (hHDC) May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. {ECO:0000303|PubMed:11696983}.
Q9UDY2 TJP2 S266 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UF56 FBXL17 S303 ochoa F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}.
Q9UHV7 MED13 S504 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9ULL8 SHROOM4 S729 ochoa Protein Shroom4 (Second homolog of apical protein) Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}.
Q9UN79 SOX13 S371 ochoa Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
Q9UNZ2 NSFL1C S140 ochoa|psp NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPQ9 TNRC6B S803 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UQ35 SRRM2 S297 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2314 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2H6 FNDC3A S114 ochoa Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.
Q9Y3Q8 TSC22D4 S145 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y3S1 WNK2 S49 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4H2 IRS2 S770 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y5Y4 PTGDR2 S350 ochoa Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
Q92974 ARHGEF2 S896 GPS6|EPSD Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.
Q96DV4 MRPL38 S129 Sugiyama Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38) None
Q8WYR1 PIK3R5 S446 Sugiyama Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
P51813 BMX S369 Sugiyama Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
Q9NQU5 PAK6 S202 Sugiyama Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
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reactome_id name p -log10_p
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.000002 5.767
R-HSA-9764561 Regulation of CDH1 Function 0.000041 4.392
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.000085 4.071
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.000120 3.921
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.000153 3.815
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.000264 3.579
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.000600 3.222
R-HSA-8878171 Transcriptional regulation by RUNX1 0.000600 3.222
R-HSA-9707616 Heme signaling 0.000578 3.238
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.000524 3.280
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.000524 3.280
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.001082 2.966
R-HSA-437239 Recycling pathway of L1 0.001947 2.711
R-HSA-418990 Adherens junctions interactions 0.002038 2.691
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.002749 2.561
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.002696 2.569
R-HSA-8986944 Transcriptional Regulation by MECP2 0.002749 2.561
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.003391 2.470
R-HSA-157118 Signaling by NOTCH 0.003480 2.458
R-HSA-193648 NRAGE signals death through JNK 0.003345 2.476
R-HSA-196025 Formation of annular gap junctions 0.005003 2.301
R-HSA-190873 Gap junction degradation 0.005917 2.228
R-HSA-2025928 Calcineurin activates NFAT 0.005917 2.228
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.005003 2.301
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.005111 2.291
R-HSA-421270 Cell-cell junction organization 0.004449 2.352
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.005805 2.236
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.007143 2.146
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.006965 2.157
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.007592 2.120
R-HSA-446728 Cell junction organization 0.007707 2.113
R-HSA-9013694 Signaling by NOTCH4 0.007917 2.101
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.008650 2.063
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.009077 2.042
R-HSA-9616334 Defective Base Excision Repair Associated with NEIL1 0.009395 2.027
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.010264 1.989
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.010264 1.989
R-HSA-195721 Signaling by WNT 0.011093 1.955
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.012832 1.892
R-HSA-201681 TCF dependent signaling in response to WNT 0.012824 1.892
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.012832 1.892
R-HSA-9909396 Circadian clock 0.013667 1.864
R-HSA-446353 Cell-extracellular matrix interactions 0.014210 1.847
R-HSA-75153 Apoptotic execution phase 0.014940 1.826
R-HSA-1500931 Cell-Cell communication 0.014986 1.824
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.017148 1.766
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.015649 1.806
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.017148 1.766
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.017218 1.764
R-HSA-157858 Gap junction trafficking and regulation 0.017218 1.764
R-HSA-2028269 Signaling by Hippo 0.018706 1.728
R-HSA-193704 p75 NTR receptor-mediated signalling 0.020985 1.678
R-HSA-70171 Glycolysis 0.021604 1.665
R-HSA-8942233 Intestinal infectious diseases 0.027923 1.554
R-HSA-5545619 XAV939 stabilizes AXIN 0.027923 1.554
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.055071 1.259
R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 0.055071 1.259
R-HSA-5083630 Defective LFNG causes SCDO3 0.055071 1.259
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 0.055071 1.259
R-HSA-74713 IRS activation 0.063952 1.194
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.063952 1.194
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.072751 1.138
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.072751 1.138
R-HSA-109703 PKB-mediated events 0.072751 1.138
R-HSA-165160 PDE3B signalling 0.072751 1.138
R-HSA-5340588 Signaling by RNF43 mutants 0.072751 1.138
R-HSA-5688890 Defective CSF2RA causes SMDP4 0.072751 1.138
R-HSA-5688849 Defective CSF2RB causes SMDP5 0.072751 1.138
R-HSA-9027283 Erythropoietin activates STAT5 0.081466 1.089
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.090101 1.045
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.090101 1.045
R-HSA-112412 SOS-mediated signalling 0.090101 1.045
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.098655 1.006
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 0.107129 0.970
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.107129 0.970
R-HSA-9020958 Interleukin-21 signaling 0.107129 0.970
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.115524 0.937
R-HSA-390450 Folding of actin by CCT/TriC 0.115524 0.937
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.123840 0.907
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.037239 1.429
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.140241 0.853
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.140241 0.853
R-HSA-9006335 Signaling by Erythropoietin 0.043747 1.359
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.043747 1.359
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.046003 1.337
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.048302 1.316
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.048302 1.316
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.164271 0.784
R-HSA-9027284 Erythropoietin activates RAS 0.164271 0.784
R-HSA-111447 Activation of BAD and translocation to mitochondria 0.164271 0.784
R-HSA-1855170 IPs transport between nucleus and cytosol 0.053021 1.276
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.053021 1.276
R-HSA-390522 Striated Muscle Contraction 0.055440 1.256
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.055440 1.256
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.060391 1.219
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.070723 1.150
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.073391 1.134
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.202849 0.693
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.135614 0.868
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.135614 0.868
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.135614 0.868
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.135614 0.868
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.135614 0.868
R-HSA-1989781 PPARA activates gene expression 0.082376 1.084
R-HSA-1980143 Signaling by NOTCH1 0.045957 1.338
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.085059 1.070
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.053021 1.276
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.147172 0.832
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.147172 0.832
R-HSA-198203 PI3K/AKT activation 0.115524 0.937
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.151767 0.819
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.147172 0.832
R-HSA-191650 Regulation of gap junction activity 0.055071 1.259
R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 0.063952 1.194
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.178323 0.749
R-HSA-4641265 Repression of WNT target genes 0.140241 0.853
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.063952 1.194
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.156336 0.806
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.065488 1.184
R-HSA-5674135 MAP2K and MAPK activation 0.078820 1.103
R-HSA-112399 IRS-mediated signalling 0.126123 0.899
R-HSA-2428928 IRS-related events triggered by IGF1R 0.138813 0.858
R-HSA-9839394 TGFBR3 expression 0.035160 1.454
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.136313 0.865
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.132432 0.878
R-HSA-171319 Telomere Extension By Telomerase 0.041533 1.382
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.132079 0.879
R-HSA-9656223 Signaling by RAF1 mutants 0.078820 1.103
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.092913 1.032
R-HSA-9649948 Signaling downstream of RAS mutants 0.092913 1.032
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.092913 1.032
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.081535 1.089
R-HSA-8856828 Clathrin-mediated endocytosis 0.195505 0.709
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.055071 1.259
R-HSA-8964540 Alanine metabolism 0.055071 1.259
R-HSA-9927354 Co-stimulation by ICOS 0.098655 1.006
R-HSA-350054 Notch-HLH transcription pathway 0.029212 1.534
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.132079 0.879
R-HSA-445095 Interaction between L1 and Ankyrins 0.039364 1.405
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.148326 0.829
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.065488 1.184
R-HSA-4641263 Regulation of FZD by ubiquitination 0.187635 0.727
R-HSA-194441 Metabolism of non-coding RNA 0.026137 1.583
R-HSA-191859 snRNP Assembly 0.026137 1.583
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.195277 0.709
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.090038 1.046
R-HSA-109704 PI3K Cascade 0.104668 0.980
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.076366 1.117
R-HSA-5693606 DNA Double Strand Break Response 0.158332 0.800
R-HSA-6807070 PTEN Regulation 0.183645 0.736
R-HSA-74751 Insulin receptor signalling cascade 0.148506 0.828
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.077138 1.113
R-HSA-2428924 IGF1R signaling cascade 0.148506 0.828
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.140241 0.853
R-HSA-6802949 Signaling by RAS mutants 0.092913 1.032
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.098655 1.006
R-HSA-74749 Signal attenuation 0.115524 0.937
R-HSA-9824272 Somitogenesis 0.090038 1.046
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.151767 0.819
R-HSA-3214858 RMTs methylate histone arginines 0.087191 1.060
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.090101 1.045
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.098655 1.006
R-HSA-9761174 Formation of intermediate mesoderm 0.115524 0.937
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.053021 1.276
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.055440 1.256
R-HSA-180786 Extension of Telomeres 0.026137 1.583
R-HSA-9793380 Formation of paraxial mesoderm 0.028166 1.550
R-HSA-9708530 Regulation of BACH1 activity 0.172132 0.764
R-HSA-114452 Activation of BH3-only proteins 0.046003 1.337
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.161634 0.791
R-HSA-5693532 DNA Double-Strand Break Repair 0.079735 1.098
R-HSA-8964046 VLDL clearance 0.090101 1.045
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 0.115524 0.937
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.179920 0.745
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.195277 0.709
R-HSA-168325 Viral Messenger RNA Synthesis 0.138813 0.858
R-HSA-1257604 PIP3 activates AKT signaling 0.030726 1.512
R-HSA-9711123 Cellular response to chemical stress 0.138111 0.860
R-HSA-157579 Telomere Maintenance 0.083291 1.079
R-HSA-9843745 Adipogenesis 0.162827 0.788
R-HSA-9932444 ATP-dependent chromatin remodelers 0.035160 1.454
R-HSA-9932451 SWI/SNF chromatin remodelers 0.035160 1.454
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.188365 0.725
R-HSA-73886 Chromosome Maintenance 0.136313 0.865
R-HSA-5687613 Diseases associated with surfactant metabolism 0.140241 0.853
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.156336 0.806
R-HSA-180746 Nuclear import of Rev protein 0.057897 1.237
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.032245 1.492
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.179920 0.745
R-HSA-5689603 UCH proteinases 0.188461 0.725
R-HSA-3214847 HATs acetylate histones 0.086852 1.061
R-HSA-68875 Mitotic Prophase 0.134176 0.872
R-HSA-9605308 Diseases of Base Excision Repair 0.072751 1.138
R-HSA-9664407 Parasite infection 0.186001 0.730
R-HSA-9664417 Leishmania phagocytosis 0.186001 0.730
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.186001 0.730
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.107129 0.970
R-HSA-428540 Activation of RAC1 0.132079 0.879
R-HSA-177243 Interactions of Rev with host cellular proteins 0.073391 1.134
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.073391 1.134
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.076090 1.119
R-HSA-445355 Smooth Muscle Contraction 0.113735 0.944
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.174963 0.757
R-HSA-69473 G2/M DNA damage checkpoint 0.181693 0.741
R-HSA-9006925 Intracellular signaling by second messengers 0.056952 1.244
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.039364 1.405
R-HSA-5693538 Homology Directed Repair 0.037226 1.429
R-HSA-9819196 Zygotic genome activation (ZGA) 0.025496 1.594
R-HSA-4086398 Ca2+ pathway 0.178323 0.749
R-HSA-9839373 Signaling by TGFBR3 0.092913 1.032
R-HSA-3858494 Beta-catenin independent WNT signaling 0.176626 0.753
R-HSA-4839726 Chromatin organization 0.043252 1.364
R-HSA-4086400 PCP/CE pathway 0.195263 0.709
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.063952 1.194
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.156336 0.806
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.164271 0.784
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.068089 1.167
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.195277 0.709
R-HSA-190828 Gap junction trafficking 0.087191 1.060
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.092913 1.032
R-HSA-5578749 Transcriptional regulation by small RNAs 0.174963 0.757
R-HSA-3247509 Chromatin modifying enzymes 0.034289 1.465
R-HSA-451927 Interleukin-2 family signaling 0.073391 1.134
R-HSA-9768759 Regulation of NPAS4 gene expression 0.187635 0.727
R-HSA-449836 Other interleukin signaling 0.202849 0.693
R-HSA-9675135 Diseases of DNA repair 0.092913 1.032
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.048664 1.313
R-HSA-73894 DNA Repair 0.151756 0.819
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.070723 1.150
R-HSA-2980766 Nuclear Envelope Breakdown 0.126123 0.899
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.129268 0.889
R-HSA-9659379 Sensory processing of sound 0.198676 0.702
R-HSA-397014 Muscle contraction 0.177506 0.751
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.148326 0.829
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.185072 0.733
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.122996 0.910
R-HSA-6784531 tRNA processing in the nucleus 0.142028 0.848
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.161634 0.791
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.140623 0.852
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.046003 1.337
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.168275 0.774
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.178323 0.749
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.140623 0.852
R-HSA-4791275 Signaling by WNT in cancer 0.050642 1.295
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.122996 0.910
R-HSA-9758941 Gastrulation 0.074584 1.127
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.029212 1.534
R-HSA-74160 Gene expression (Transcription) 0.033253 1.478
R-HSA-5673001 RAF/MAP kinase cascade 0.169218 0.772
R-HSA-391908 Prostanoid ligand receptors 0.123840 0.907
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.140241 0.853
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.046003 1.337
R-HSA-8876725 Protein methylation 0.164271 0.784
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.095814 1.019
R-HSA-373760 L1CAM interactions 0.035519 1.450
R-HSA-5684996 MAPK1/MAPK3 signaling 0.180157 0.744
R-HSA-162582 Signal Transduction 0.025179 1.599
R-HSA-2586552 Signaling by Leptin 0.115524 0.937
R-HSA-1834941 STING mediated induction of host immune responses 0.202849 0.693
R-HSA-212436 Generic Transcription Pathway 0.040131 1.397
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.148326 0.829
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.158303 0.801
R-HSA-73857 RNA Polymerase II Transcription 0.053692 1.270
R-HSA-70268 Pyruvate metabolism 0.063332 1.198
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.037226 1.429
R-HSA-5683057 MAPK family signaling cascades 0.135373 0.868
R-HSA-1640170 Cell Cycle 0.044193 1.355
R-HSA-109581 Apoptosis 0.028736 1.542
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.158332 0.800
R-HSA-9012852 Signaling by NOTCH3 0.119888 0.921
R-HSA-70326 Glucose metabolism 0.036367 1.439
R-HSA-211000 Gene Silencing by RNA 0.103644 0.984
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.145259 0.838
R-HSA-3371556 Cellular response to heat stress 0.136313 0.865
R-HSA-416482 G alpha (12/13) signalling events 0.048664 1.313
R-HSA-3700989 Transcriptional Regulation by TP53 0.177437 0.751
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.110690 0.956
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.193117 0.714
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.098740 1.006
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.052869 1.277
R-HSA-1169408 ISG15 antiviral mechanism 0.185072 0.733
R-HSA-5357801 Programmed Cell Death 0.063177 1.199
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.168275 0.774
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.198676 0.702
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.068089 1.167
R-HSA-1592230 Mitochondrial biogenesis 0.127836 0.893
R-HSA-1483255 PI Metabolism 0.092312 1.035
R-HSA-3928662 EPHB-mediated forward signaling 0.087191 1.060
R-HSA-186712 Regulation of beta-cell development 0.132432 0.878
R-HSA-73887 Death Receptor Signaling 0.081050 1.091
R-HSA-1474244 Extracellular matrix organization 0.116451 0.934
R-HSA-5693607 Processing of DNA double-strand break ends 0.205524 0.687
R-HSA-9705683 SARS-CoV-2-host interactions 0.207964 0.682
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.208958 0.680
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.210349 0.677
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.210349 0.677
R-HSA-5620916 VxPx cargo-targeting to cilium 0.210349 0.677
R-HSA-391903 Eicosanoid ligand-binding receptors 0.210349 0.677
R-HSA-9707564 Cytoprotection by HMOX1 0.212397 0.673
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.217779 0.662
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.217779 0.662
R-HSA-6802957 Oncogenic MAPK signaling 0.219293 0.659
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.222215 0.653
R-HSA-212165 Epigenetic regulation of gene expression 0.224634 0.649
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.225140 0.648
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.225140 0.648
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.225140 0.648
R-HSA-977347 Serine metabolism 0.225140 0.648
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.232107 0.634
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.232432 0.634
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.232432 0.634
R-HSA-8964038 LDL clearance 0.232432 0.634
R-HSA-8943723 Regulation of PTEN mRNA translation 0.239656 0.620
R-HSA-912526 Interleukin receptor SHC signaling 0.239656 0.620
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.239656 0.620
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.239656 0.620
R-HSA-9830674 Formation of the ureteric bud 0.239656 0.620
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.239656 0.620
R-HSA-982772 Growth hormone receptor signaling 0.239656 0.620
R-HSA-933542 TRAF6 mediated NF-kB activation 0.246813 0.608
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.246813 0.608
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.246813 0.608
R-HSA-74752 Signaling by Insulin receptor 0.250515 0.601
R-HSA-2682334 EPH-Ephrin signaling 0.250515 0.601
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.253902 0.595
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.253902 0.595
R-HSA-9620244 Long-term potentiation 0.253902 0.595
R-HSA-1266695 Interleukin-7 signaling 0.253902 0.595
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.260925 0.583
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.260925 0.583
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.260925 0.583
R-HSA-525793 Myogenesis 0.260925 0.583
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.260925 0.583
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.260962 0.583
R-HSA-5621481 C-type lectin receptors (CLRs) 0.267294 0.573
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.267883 0.572
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.267930 0.572
R-HSA-8878159 Transcriptional regulation by RUNX3 0.271414 0.566
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.274775 0.561
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.274923 0.561
R-HSA-2262752 Cellular responses to stress 0.276998 0.558
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.277471 0.557
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.281603 0.550
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.281603 0.550
R-HSA-422475 Axon guidance 0.287580 0.541
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.288367 0.540
R-HSA-8863795 Downregulation of ERBB2 signaling 0.288367 0.540
R-HSA-9842860 Regulation of endogenous retroelements 0.288822 0.539
R-HSA-2559580 Oxidative Stress Induced Senescence 0.288822 0.539
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.288822 0.539
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.295068 0.530
R-HSA-9833109 Evasion by RSV of host interferon responses 0.295068 0.530
R-HSA-9833110 RSV-host interactions 0.299246 0.524
R-HSA-8953897 Cellular responses to stimuli 0.307757 0.512
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.308282 0.511
R-HSA-9022692 Regulation of MECP2 expression and activity 0.308282 0.511
R-HSA-397795 G-protein beta:gamma signalling 0.308282 0.511
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.308282 0.511
R-HSA-176187 Activation of ATR in response to replication stress 0.308282 0.511
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.308282 0.511
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.309647 0.509
R-HSA-9700206 Signaling by ALK in cancer 0.309647 0.509
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.313108 0.504
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.314796 0.502
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.314796 0.502
R-HSA-5693537 Resolution of D-Loop Structures 0.314796 0.502
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.321250 0.493
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.321250 0.493
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.321250 0.493
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.321250 0.493
R-HSA-9768919 NPAS4 regulates expression of target genes 0.321250 0.493
R-HSA-1483249 Inositol phosphate metabolism 0.326911 0.486
R-HSA-2559585 Oncogene Induced Senescence 0.327643 0.485
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.327643 0.485
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.327643 0.485
R-HSA-114604 GPVI-mediated activation cascade 0.333976 0.476
R-HSA-8853659 RET signaling 0.333976 0.476
R-HSA-8941326 RUNX2 regulates bone development 0.333976 0.476
R-HSA-4641257 Degradation of AXIN 0.340250 0.468
R-HSA-933541 TRAF6 mediated IRF7 activation 0.340250 0.468
R-HSA-9675108 Nervous system development 0.343370 0.464
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.344061 0.463
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.344061 0.463
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.346466 0.460
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.349332 0.457
R-HSA-8964043 Plasma lipoprotein clearance 0.352623 0.453
R-HSA-3371568 Attenuation phase 0.358722 0.445
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.364765 0.438
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.364765 0.438
R-HSA-8853884 Transcriptional Regulation by VENTX 0.364765 0.438
R-HSA-3214841 PKMTs methylate histone lysines 0.364765 0.438
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.370751 0.431
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.370751 0.431
R-HSA-162909 Host Interactions of HIV factors 0.374563 0.426
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.376680 0.424
R-HSA-73928 Depyrimidination 0.376680 0.424
R-HSA-110329 Cleavage of the damaged pyrimidine 0.376680 0.424
R-HSA-9730414 MITF-M-regulated melanocyte development 0.377496 0.423
R-HSA-194138 Signaling by VEGF 0.381266 0.419
R-HSA-69481 G2/M Checkpoints 0.387940 0.411
R-HSA-5683826 Surfactant metabolism 0.388374 0.411
R-HSA-69236 G1 Phase 0.388374 0.411
R-HSA-69231 Cyclin D associated events in G1 0.388374 0.411
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.388374 0.411
R-HSA-4608870 Asymmetric localization of PCP proteins 0.394139 0.404
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.394139 0.404
R-HSA-2299718 Condensation of Prophase Chromosomes 0.399850 0.398
R-HSA-9861718 Regulation of pyruvate metabolism 0.399850 0.398
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.399850 0.398
R-HSA-1852241 Organelle biogenesis and maintenance 0.400050 0.398
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.411112 0.386
R-HSA-389356 Co-stimulation by CD28 0.411112 0.386
R-HSA-9018519 Estrogen-dependent gene expression 0.424051 0.373
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.427281 0.369
R-HSA-3371571 HSF1-dependent transactivation 0.427612 0.369
R-HSA-70895 Branched-chain amino acid catabolism 0.427612 0.369
R-HSA-2514856 The phototransduction cascade 0.427612 0.369
R-HSA-5339562 Uptake and actions of bacterial toxins 0.433009 0.364
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.438356 0.358
R-HSA-1221632 Meiotic synapsis 0.438356 0.358
R-HSA-8948751 Regulation of PTEN stability and activity 0.438356 0.358
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.443652 0.353
R-HSA-162599 Late Phase of HIV Life Cycle 0.446458 0.350
R-HSA-418597 G alpha (z) signalling events 0.448900 0.348
R-HSA-9694516 SARS-CoV-2 Infection 0.460920 0.336
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.464348 0.333
R-HSA-429914 Deadenylation-dependent mRNA decay 0.469401 0.328
R-HSA-9856651 MITF-M-dependent gene expression 0.471464 0.327
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.474406 0.324
R-HSA-8943724 Regulation of PTEN gene transcription 0.474406 0.324
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.474406 0.324
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.474406 0.324
R-HSA-1227986 Signaling by ERBB2 0.474406 0.324
R-HSA-69278 Cell Cycle, Mitotic 0.479778 0.319
R-HSA-5688426 Deubiquitination 0.481802 0.317
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.483714 0.315
R-HSA-388841 Regulation of T cell activation by CD28 family 0.484194 0.315
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.486749 0.313
R-HSA-69620 Cell Cycle Checkpoints 0.488962 0.311
R-HSA-9610379 HCMV Late Events 0.492787 0.307
R-HSA-162587 HIV Life Cycle 0.492787 0.307
R-HSA-1266738 Developmental Biology 0.495013 0.305
R-HSA-1234174 Cellular response to hypoxia 0.498740 0.302
R-HSA-9006936 Signaling by TGFB family members 0.501759 0.300
R-HSA-5633007 Regulation of TP53 Activity 0.501759 0.300
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.503471 0.298
R-HSA-9830369 Kidney development 0.508157 0.294
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.521954 0.282
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.521954 0.282
R-HSA-5619102 SLC transporter disorders 0.522296 0.282
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.526468 0.279
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.526468 0.279
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.526468 0.279
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.526468 0.279
R-HSA-68886 M Phase 0.529420 0.276
R-HSA-72306 tRNA processing 0.533777 0.273
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.537678 0.269
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.539447 0.268
R-HSA-9658195 Leishmania infection 0.542182 0.266
R-HSA-9824443 Parasitic Infection Pathways 0.542182 0.266
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.552671 0.258
R-HSA-383280 Nuclear Receptor transcription pathway 0.556895 0.254
R-HSA-168255 Influenza Infection 0.558918 0.253
R-HSA-2559583 Cellular Senescence 0.561652 0.251
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.565227 0.248
R-HSA-1483257 Phospholipid metabolism 0.572989 0.242
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.581425 0.236
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.581425 0.236
R-HSA-1500620 Meiosis 0.585380 0.233
R-HSA-5687128 MAPK6/MAPK4 signaling 0.585380 0.233
R-HSA-141424 Amplification of signal from the kinetochores 0.589298 0.230
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.589298 0.230
R-HSA-372790 Signaling by GPCR 0.591281 0.228
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.593179 0.227
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.593179 0.227
R-HSA-390466 Chaperonin-mediated protein folding 0.597024 0.224
R-HSA-438064 Post NMDA receptor activation events 0.597024 0.224
R-HSA-9609690 HCMV Early Events 0.603748 0.219
R-HSA-112310 Neurotransmitter release cycle 0.608343 0.216
R-HSA-73884 Base Excision Repair 0.608343 0.216
R-HSA-373080 Class B/2 (Secretin family receptors) 0.608343 0.216
R-HSA-389948 Co-inhibition by PD-1 0.613787 0.212
R-HSA-391251 Protein folding 0.619346 0.208
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.619346 0.208
R-HSA-376176 Signaling by ROBO receptors 0.621189 0.207
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.622945 0.206
R-HSA-388396 GPCR downstream signalling 0.627638 0.202
R-HSA-5389840 Mitochondrial translation elongation 0.637006 0.196
R-HSA-5368286 Mitochondrial translation initiation 0.643840 0.191
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.643840 0.191
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.643840 0.191
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.643840 0.191
R-HSA-9614085 FOXO-mediated transcription 0.647209 0.189
R-HSA-69618 Mitotic Spindle Checkpoint 0.650546 0.187
R-HSA-2408557 Selenocysteine synthesis 0.653852 0.185
R-HSA-68882 Mitotic Anaphase 0.654297 0.184
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.656572 0.183
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.657126 0.182
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.660325 0.180
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.660370 0.180
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.663584 0.178
R-HSA-9860931 Response of endothelial cells to shear stress 0.663584 0.178
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.664785 0.177
R-HSA-5619507 Activation of HOX genes during differentiation 0.666767 0.176
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.666767 0.176
R-HSA-5696398 Nucleotide Excision Repair 0.669921 0.174
R-HSA-162906 HIV Infection 0.678672 0.168
R-HSA-2672351 Stimuli-sensing channels 0.679204 0.168
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.679204 0.168
R-HSA-5419276 Mitochondrial translation termination 0.682240 0.166
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.682240 0.166
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.682240 0.166
R-HSA-2871796 FCERI mediated MAPK activation 0.691179 0.160
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.694103 0.159
R-HSA-9855142 Cellular responses to mechanical stimuli 0.697000 0.157
R-HSA-8939211 ESR-mediated signaling 0.699609 0.155
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.702711 0.153
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.702711 0.153
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.716525 0.145
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.716525 0.145
R-HSA-8878166 Transcriptional regulation by RUNX2 0.716525 0.145
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.718223 0.144
R-HSA-5619115 Disorders of transmembrane transporters 0.719411 0.143
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.721870 0.142
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.724506 0.140
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.724506 0.140
R-HSA-9609646 HCMV Infection 0.725136 0.140
R-HSA-977606 Regulation of Complement cascade 0.732263 0.135
R-HSA-168249 Innate Immune System 0.736547 0.133
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.742269 0.129
R-HSA-9734767 Developmental Cell Lineages 0.748818 0.126
R-HSA-1474165 Reproduction 0.749529 0.125
R-HSA-5368287 Mitochondrial translation 0.770113 0.113
R-HSA-1632852 Macroautophagy 0.776594 0.110
R-HSA-166658 Complement cascade 0.786994 0.104
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.789016 0.103
R-HSA-2187338 Visual phototransduction 0.791018 0.102
R-HSA-166520 Signaling by NTRKs 0.793002 0.101
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.793002 0.101
R-HSA-9679506 SARS-CoV Infections 0.796215 0.099
R-HSA-9612973 Autophagy 0.808212 0.092
R-HSA-2467813 Separation of Sister Chromatids 0.822311 0.085
R-HSA-2408522 Selenoamino acid metabolism 0.822311 0.085
R-HSA-8953854 Metabolism of RNA 0.823412 0.084
R-HSA-418555 G alpha (s) signalling events 0.835381 0.078
R-HSA-112315 Transmission across Chemical Synapses 0.836695 0.077
R-HSA-8957322 Metabolism of steroids 0.837892 0.077
R-HSA-5689880 Ub-specific processing proteases 0.838496 0.076
R-HSA-3781865 Diseases of glycosylation 0.854611 0.068
R-HSA-71291 Metabolism of amino acids and derivatives 0.856947 0.067
R-HSA-69275 G2/M Transition 0.857365 0.067
R-HSA-453274 Mitotic G2-G2/M phases 0.860067 0.065
R-HSA-983712 Ion channel transport 0.861398 0.065
R-HSA-449147 Signaling by Interleukins 0.862647 0.064
R-HSA-5617833 Cilium Assembly 0.862717 0.064
R-HSA-168898 Toll-like Receptor Cascades 0.864024 0.063
R-HSA-68877 Mitotic Prometaphase 0.866601 0.062
R-HSA-72163 mRNA Splicing - Major Pathway 0.867870 0.062
R-HSA-428157 Sphingolipid metabolism 0.876430 0.057
R-HSA-9006931 Signaling by Nuclear Receptors 0.878841 0.056
R-HSA-199991 Membrane Trafficking 0.880041 0.055
R-HSA-72172 mRNA Splicing 0.881071 0.055
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.889841 0.051
R-HSA-913531 Interferon Signaling 0.896740 0.047
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.906401 0.043
R-HSA-418594 G alpha (i) signalling events 0.914188 0.039
R-HSA-1643685 Disease 0.917946 0.037
R-HSA-5668914 Diseases of metabolism 0.926587 0.033
R-HSA-416476 G alpha (q) signalling events 0.933107 0.030
R-HSA-76002 Platelet activation, signaling and aggregation 0.939237 0.027
R-HSA-1280218 Adaptive Immune System 0.941728 0.026
R-HSA-6798695 Neutrophil degranulation 0.942076 0.026
R-HSA-112316 Neuronal System 0.946940 0.024
R-HSA-109582 Hemostasis 0.948785 0.023
R-HSA-1280215 Cytokine Signaling in Immune system 0.950387 0.022
R-HSA-5653656 Vesicle-mediated transport 0.956281 0.019
R-HSA-168256 Immune System 0.958727 0.018
R-HSA-597592 Post-translational protein modification 0.961634 0.017
R-HSA-556833 Metabolism of lipids 0.977469 0.010
R-HSA-500792 GPCR ligand binding 0.980280 0.009
R-HSA-9824439 Bacterial Infection Pathways 0.980354 0.009
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.981101 0.008
R-HSA-5663205 Infectious disease 0.984469 0.007
R-HSA-9824446 Viral Infection Pathways 0.985811 0.006
R-HSA-72766 Translation 0.986541 0.006
R-HSA-392499 Metabolism of proteins 0.997397 0.001
R-HSA-382551 Transport of small molecules 0.999364 0.000
R-HSA-9709957 Sensory Perception 0.999589 0.000
R-HSA-1430728 Metabolism 0.999959 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.855 0.692 1 0.899
CDK19CDK19 0.852 0.685 1 0.901
DYRK2DYRK2 0.851 0.684 1 0.884
CDK8CDK8 0.851 0.685 1 0.897
CLK3CLK3 0.850 0.516 1 0.732
HIPK4HIPK4 0.849 0.533 1 0.779
KISKIS 0.848 0.633 1 0.901
JNK2JNK2 0.846 0.734 1 0.916
CDK18CDK18 0.844 0.688 1 0.894
DYRK4DYRK4 0.843 0.672 1 0.907
CDK7CDK7 0.841 0.662 1 0.900
P38GP38G 0.840 0.710 1 0.891
CDK1CDK1 0.840 0.677 1 0.884
CDK3CDK3 0.840 0.645 1 0.887
JNK3JNK3 0.840 0.717 1 0.911
HIPK1HIPK1 0.839 0.641 1 0.881
CDK13CDK13 0.837 0.662 1 0.908
P38DP38D 0.837 0.701 1 0.910
ERK1ERK1 0.836 0.671 1 0.906
CDK17CDK17 0.835 0.683 1 0.885
CDK12CDK12 0.835 0.667 1 0.913
DYRK1BDYRK1B 0.835 0.650 1 0.881
SRPK1SRPK1 0.834 0.354 -3 0.750
P38BP38B 0.833 0.676 1 0.893
CDK5CDK5 0.831 0.638 1 0.881
CDK9CDK9 0.829 0.649 1 0.910
NLKNLK 0.829 0.599 1 0.807
CLK2CLK2 0.828 0.422 -3 0.737
DYRK1ADYRK1A 0.828 0.551 1 0.878
CLK1CLK1 0.827 0.434 -3 0.739
HIPK3HIPK3 0.826 0.609 1 0.877
MTORMTOR 0.826 0.279 1 0.662
P38AP38A 0.825 0.648 1 0.879
CDK16CDK16 0.825 0.646 1 0.887
CLK4CLK4 0.823 0.389 -3 0.753
DYRK3DYRK3 0.823 0.508 1 0.862
SRPK2SRPK2 0.822 0.290 -3 0.683
JNK1JNK1 0.820 0.633 1 0.899
ERK2ERK2 0.820 0.640 1 0.895
CDK14CDK14 0.819 0.638 1 0.898
ICKICK 0.819 0.353 -3 0.816
CDK10CDK10 0.818 0.611 1 0.898
ERK5ERK5 0.816 0.316 1 0.707
PRKD1PRKD1 0.816 0.124 -3 0.809
COTCOT 0.816 -0.014 2 0.801
CDK2CDK2 0.814 0.518 1 0.844
MAKMAK 0.813 0.467 -2 0.731
CDKL5CDKL5 0.813 0.191 -3 0.787
CDK4CDK4 0.812 0.638 1 0.915
CDKL1CDKL1 0.812 0.182 -3 0.788
CDK6CDK6 0.810 0.617 1 0.904
PRKD2PRKD2 0.810 0.114 -3 0.764
CDC7CDC7 0.810 -0.028 1 0.480
PRP4PRP4 0.809 0.450 -3 0.769
NDR2NDR2 0.809 0.041 -3 0.797
SRPK3SRPK3 0.809 0.240 -3 0.713
TBK1TBK1 0.808 -0.045 1 0.530
PIM3PIM3 0.807 0.043 -3 0.802
IKKBIKKB 0.806 -0.070 -2 0.699
NEK6NEK6 0.805 0.025 -2 0.793
IKKEIKKE 0.805 -0.055 1 0.531
RSK2RSK2 0.804 0.075 -3 0.775
PRPKPRPK 0.804 -0.069 -1 0.819
RAF1RAF1 0.804 -0.066 1 0.547
MOSMOS 0.803 0.005 1 0.541
ATRATR 0.803 0.002 1 0.558
CHAK2CHAK2 0.802 0.047 -1 0.844
DSTYKDSTYK 0.802 -0.046 2 0.822
CAMK1BCAMK1B 0.801 0.021 -3 0.823
GCN2GCN2 0.801 -0.129 2 0.733
MST4MST4 0.801 0.029 2 0.799
PIM1PIM1 0.801 0.092 -3 0.751
PDHK4PDHK4 0.801 -0.116 1 0.600
MOKMOK 0.801 0.438 1 0.800
PKN3PKN3 0.800 0.021 -3 0.787
ULK2ULK2 0.800 -0.106 2 0.723
NUAK2NUAK2 0.799 0.058 -3 0.801
WNK1WNK1 0.799 -0.003 -2 0.860
P90RSKP90RSK 0.799 0.061 -3 0.780
LATS2LATS2 0.799 0.018 -5 0.770
RSK3RSK3 0.799 0.057 -3 0.764
PKCDPKCD 0.799 0.045 2 0.728
IKKAIKKA 0.799 -0.016 -2 0.693
MARK4MARK4 0.799 0.010 4 0.776
CAMK2DCAMK2D 0.798 0.010 -3 0.809
MAPKAPK2MAPKAPK2 0.798 0.059 -3 0.723
SKMLCKSKMLCK 0.798 0.016 -2 0.829
PDHK1PDHK1 0.798 -0.096 1 0.598
CAMK2GCAMK2G 0.798 -0.058 2 0.763
NEK7NEK7 0.797 -0.066 -3 0.807
NDR1NDR1 0.797 -0.003 -3 0.796
MAPKAPK3MAPKAPK3 0.797 0.032 -3 0.758
NIKNIK 0.796 0.007 -3 0.825
AURCAURC 0.795 0.057 -2 0.593
BMPR2BMPR2 0.795 -0.139 -2 0.818
CAMLCKCAMLCK 0.794 0.026 -2 0.795
LATS1LATS1 0.794 0.093 -3 0.820
PKACGPKACG 0.794 0.018 -2 0.668
P70S6KBP70S6KB 0.793 0.049 -3 0.776
AMPKA1AMPKA1 0.793 -0.004 -3 0.806
DAPK2DAPK2 0.793 0.020 -3 0.832
DNAPKDNAPK 0.792 0.038 1 0.558
TSSK1TSSK1 0.792 0.021 -3 0.826
GSK3AGSK3A 0.792 0.217 4 0.503
PKN2PKN2 0.791 -0.017 -3 0.787
PRKD3PRKD3 0.791 0.065 -3 0.740
AMPKA2AMPKA2 0.791 0.019 -3 0.784
PKACBPKACB 0.790 0.067 -2 0.607
GRK7GRK7 0.790 0.057 1 0.482
CAMK2ACAMK2A 0.790 0.040 2 0.746
ULK1ULK1 0.790 -0.120 -3 0.754
ERK7ERK7 0.790 0.230 2 0.516
TGFBR2TGFBR2 0.790 -0.079 -2 0.722
CAMK2BCAMK2B 0.789 0.012 2 0.736
QSKQSK 0.789 0.034 4 0.748
NIM1NIM1 0.789 -0.017 3 0.760
RSK4RSK4 0.789 0.070 -3 0.742
PAK1PAK1 0.788 -0.002 -2 0.744
BCKDKBCKDK 0.788 -0.121 -1 0.757
GRK1GRK1 0.788 -0.032 -2 0.715
NEK9NEK9 0.788 -0.096 2 0.771
SGK3SGK3 0.788 0.075 -3 0.739
HUNKHUNK 0.787 -0.126 2 0.720
MSK2MSK2 0.787 0.011 -3 0.734
PRKXPRKX 0.787 0.083 -3 0.672
PKCAPKCA 0.786 0.025 2 0.671
PAK3PAK3 0.786 -0.023 -2 0.742
ATMATM 0.786 -0.038 1 0.503
GRK5GRK5 0.786 -0.154 -3 0.757
WNK3WNK3 0.786 -0.168 1 0.543
AKT2AKT2 0.786 0.085 -3 0.693
FAM20CFAM20C 0.786 0.043 2 0.624
MLK1MLK1 0.786 -0.148 2 0.745
SIKSIK 0.785 0.028 -3 0.742
PAK6PAK6 0.785 0.039 -2 0.653
MNK2MNK2 0.785 0.001 -2 0.747
TSSK2TSSK2 0.785 -0.037 -5 0.798
PKCBPKCB 0.785 0.005 2 0.680
MLK2MLK2 0.784 -0.090 2 0.758
TLK2TLK2 0.784 -0.023 1 0.512
RIPK3RIPK3 0.784 -0.151 3 0.698
MSK1MSK1 0.784 0.034 -3 0.732
MLK3MLK3 0.784 -0.046 2 0.687
NEK2NEK2 0.783 -0.029 2 0.761
NUAK1NUAK1 0.783 0.001 -3 0.760
PINK1PINK1 0.783 0.146 1 0.662
PKCGPKCG 0.783 -0.008 2 0.678
PHKG1PHKG1 0.782 -0.025 -3 0.791
PKRPKR 0.782 -0.022 1 0.541
BMPR1BBMPR1B 0.782 -0.010 1 0.409
MELKMELK 0.782 -0.022 -3 0.781
SMG1SMG1 0.782 -0.026 1 0.537
MNK1MNK1 0.782 0.010 -2 0.749
MASTLMASTL 0.782 -0.189 -2 0.761
ALK4ALK4 0.781 -0.023 -2 0.784
ANKRD3ANKRD3 0.781 -0.129 1 0.560
TGFBR1TGFBR1 0.781 -0.015 -2 0.758
PKCZPKCZ 0.781 -0.015 2 0.723
AURBAURB 0.781 0.015 -2 0.589
DCAMKL1DCAMKL1 0.780 0.034 -3 0.763
GRK6GRK6 0.780 -0.122 1 0.492
VRK2VRK2 0.780 0.020 1 0.613
RIPK1RIPK1 0.780 -0.172 1 0.518
YSK4YSK4 0.780 -0.084 1 0.517
DLKDLK 0.779 -0.195 1 0.525
IRE1IRE1 0.779 -0.109 1 0.499
TTBK2TTBK2 0.779 -0.163 2 0.667
BRSK1BRSK1 0.778 -0.017 -3 0.764
PIM2PIM2 0.778 0.072 -3 0.740
MARK3MARK3 0.778 -0.004 4 0.699
QIKQIK 0.778 -0.059 -3 0.800
PKG2PKG2 0.777 0.008 -2 0.604
AKT1AKT1 0.777 0.067 -3 0.706
PAK2PAK2 0.777 -0.045 -2 0.722
MPSK1MPSK1 0.777 0.079 1 0.539
MARK2MARK2 0.777 -0.016 4 0.684
CHK1CHK1 0.776 -0.020 -3 0.784
GRK4GRK4 0.776 -0.164 -2 0.758
PKCHPKCH 0.776 -0.035 2 0.658
PLK1PLK1 0.776 -0.113 -2 0.716
AURAAURA 0.776 -0.002 -2 0.565
CAMK4CAMK4 0.775 -0.103 -3 0.772
MAPKAPK5MAPKAPK5 0.775 -0.031 -3 0.713
GSK3BGSK3B 0.774 0.078 4 0.499
CHAK1CHAK1 0.774 -0.106 2 0.729
PKACAPKACA 0.774 0.043 -2 0.556
TAO3TAO3 0.774 0.025 1 0.546
BRSK2BRSK2 0.774 -0.058 -3 0.780
MEK1MEK1 0.774 -0.128 2 0.782
IRE2IRE2 0.773 -0.106 2 0.693
WNK4WNK4 0.772 -0.051 -2 0.854
PLK3PLK3 0.772 -0.096 2 0.715
NEK5NEK5 0.771 -0.041 1 0.529
SGK1SGK1 0.771 0.105 -3 0.622
MLK4MLK4 0.771 -0.111 2 0.661
BRAFBRAF 0.770 -0.057 -4 0.824
PKCTPKCT 0.770 -0.018 2 0.668
MYLK4MYLK4 0.769 -0.028 -2 0.719
ALK2ALK2 0.769 -0.058 -2 0.747
P70S6KP70S6K 0.769 0.035 -3 0.705
PLK4PLK4 0.769 -0.102 2 0.561
MST3MST3 0.769 -0.019 2 0.778
AKT3AKT3 0.768 0.081 -3 0.642
MARK1MARK1 0.768 -0.051 4 0.713
MEKK1MEKK1 0.768 -0.114 1 0.544
TLK1TLK1 0.767 -0.092 -2 0.770
PASKPASK 0.767 0.003 -3 0.814
ACVR2BACVR2B 0.767 -0.092 -2 0.734
DCAMKL2DCAMKL2 0.767 -0.015 -3 0.787
SSTKSSTK 0.766 -0.025 4 0.731
PERKPERK 0.766 -0.135 -2 0.758
SBKSBK 0.766 0.149 -3 0.597
ACVR2AACVR2A 0.766 -0.102 -2 0.720
PAK5PAK5 0.766 -0.008 -2 0.582
LKB1LKB1 0.765 0.025 -3 0.792
MEKK2MEKK2 0.765 -0.094 2 0.740
PDK1PDK1 0.765 0.010 1 0.566
CAMK1GCAMK1G 0.765 -0.037 -3 0.744
PKCIPKCI 0.765 -0.008 2 0.693
TNIKTNIK 0.765 0.054 3 0.872
ZAKZAK 0.764 -0.138 1 0.516
MEK5MEK5 0.764 -0.165 2 0.760
PAK4PAK4 0.764 0.002 -2 0.588
BUB1BUB1 0.764 0.095 -5 0.780
SNRKSNRK 0.763 -0.154 2 0.625
BMPR1ABMPR1A 0.763 -0.040 1 0.390
HRIHRI 0.762 -0.179 -2 0.783
GCKGCK 0.762 0.007 1 0.542
PKCEPKCE 0.762 0.017 2 0.664
HGKHGK 0.761 0.002 3 0.852
CAMK1DCAMK1D 0.761 0.003 -3 0.681
DRAK1DRAK1 0.761 -0.155 1 0.436
PDHK3_TYRPDHK3_TYR 0.761 0.208 4 0.836
KHS1KHS1 0.760 0.054 1 0.559
SMMLCKSMMLCK 0.760 -0.026 -3 0.788
PHKG2PHKG2 0.760 -0.069 -3 0.763
MEKK3MEKK3 0.760 -0.186 1 0.526
PKN1PKN1 0.759 0.008 -3 0.723
CK1G1CK1G1 0.759 -0.073 -3 0.421
TAO2TAO2 0.759 -0.052 2 0.786
KHS2KHS2 0.759 0.063 1 0.567
IRAK4IRAK4 0.759 -0.132 1 0.503
GRK2GRK2 0.759 -0.123 -2 0.659
NEK4NEK4 0.758 -0.062 1 0.535
MINKMINK 0.758 -0.020 1 0.539
DAPK3DAPK3 0.757 0.004 -3 0.774
NEK8NEK8 0.757 -0.122 2 0.753
GAKGAK 0.757 -0.033 1 0.540
ROCK2ROCK2 0.757 0.053 -3 0.758
HPK1HPK1 0.757 -0.001 1 0.550
CK1ECK1E 0.756 -0.074 -3 0.432
LOKLOK 0.756 -0.018 -2 0.700
NEK11NEK11 0.756 -0.119 1 0.553
MRCKAMRCKA 0.756 0.035 -3 0.733
CAMKK2CAMKK2 0.755 -0.102 -2 0.671
MAP3K15MAP3K15 0.755 -0.054 1 0.527
MST2MST2 0.755 -0.076 1 0.529
MRCKBMRCKB 0.755 0.039 -3 0.719
MEKK6MEKK6 0.754 -0.066 1 0.522
CHK2CHK2 0.754 0.028 -3 0.646
LRRK2LRRK2 0.754 -0.019 2 0.786
PBKPBK 0.754 0.013 1 0.495
NEK1NEK1 0.754 -0.053 1 0.518
LIMK2_TYRLIMK2_TYR 0.753 0.167 -3 0.841
SLKSLK 0.752 -0.033 -2 0.642
CAMKK1CAMKK1 0.752 -0.172 -2 0.670
CK2A2CK2A2 0.751 -0.021 1 0.365
DAPK1DAPK1 0.751 -0.004 -3 0.758
HASPINHASPIN 0.751 0.058 -1 0.740
TTBK1TTBK1 0.751 -0.172 2 0.584
TAK1TAK1 0.751 -0.095 1 0.529
CK1DCK1D 0.750 -0.052 -3 0.376
MAP2K4_TYRMAP2K4_TYR 0.750 0.082 -1 0.844
CAMK1ACAMK1A 0.749 0.010 -3 0.656
CRIKCRIK 0.749 0.092 -3 0.706
TESK1_TYRTESK1_TYR 0.749 0.034 3 0.872
PDHK4_TYRPDHK4_TYR 0.748 0.042 2 0.815
PKMYT1_TYRPKMYT1_TYR 0.748 0.098 3 0.827
PLK2PLK2 0.747 -0.057 -3 0.715
EEF2KEEF2K 0.747 -0.084 3 0.814
YSK1YSK1 0.747 -0.060 2 0.751
MST1MST1 0.747 -0.091 1 0.528
NEK3NEK3 0.746 -0.047 1 0.533
GRK3GRK3 0.744 -0.123 -2 0.618
MAP2K6_TYRMAP2K6_TYR 0.744 0.001 -1 0.832
STK33STK33 0.744 -0.116 2 0.563
MEK2MEK2 0.743 -0.150 2 0.754
MAP2K7_TYRMAP2K7_TYR 0.743 -0.101 2 0.793
PDHK1_TYRPDHK1_TYR 0.743 -0.022 -1 0.832
CK1A2CK1A2 0.743 -0.080 -3 0.377
VRK1VRK1 0.743 -0.175 2 0.768
ROCK1ROCK1 0.742 0.028 -3 0.730
IRAK1IRAK1 0.741 -0.261 -1 0.732
CK2A1CK2A1 0.741 -0.035 1 0.350
PKG1PKG1 0.741 -0.022 -2 0.531
DMPK1DMPK1 0.740 0.039 -3 0.737
BMPR2_TYRBMPR2_TYR 0.739 -0.032 -1 0.795
PINK1_TYRPINK1_TYR 0.739 -0.137 1 0.559
RETRET 0.738 -0.099 1 0.554
LIMK1_TYRLIMK1_TYR 0.737 -0.035 2 0.792
OSR1OSR1 0.737 -0.060 2 0.740
MYO3BMYO3B 0.737 -0.026 2 0.778
TAO1TAO1 0.736 -0.053 1 0.518
NEK10_TYRNEK10_TYR 0.735 -0.031 1 0.508
JAK2JAK2 0.734 -0.094 1 0.565
ASK1ASK1 0.734 -0.087 1 0.522
MST1RMST1R 0.734 -0.101 3 0.770
RIPK2RIPK2 0.732 -0.238 1 0.498
BIKEBIKE 0.732 -0.029 1 0.480
MYO3AMYO3A 0.732 -0.055 1 0.541
TYK2TYK2 0.731 -0.185 1 0.548
CSF1RCSF1R 0.730 -0.102 3 0.748
ABL2ABL2 0.729 -0.062 -1 0.749
ROS1ROS1 0.729 -0.131 3 0.733
TNNI3K_TYRTNNI3K_TYR 0.729 -0.028 1 0.557
JAK1JAK1 0.728 -0.052 1 0.534
DDR1DDR1 0.727 -0.163 4 0.751
TNK1TNK1 0.727 -0.054 3 0.755
AAK1AAK1 0.726 0.019 1 0.434
TYRO3TYRO3 0.726 -0.176 3 0.770
TNK2TNK2 0.726 -0.081 3 0.707
ABL1ABL1 0.726 -0.076 -1 0.747
EPHA6EPHA6 0.725 -0.118 -1 0.770
EPHB4EPHB4 0.725 -0.127 -1 0.769
TTKTTK 0.725 -0.130 -2 0.740
JAK3JAK3 0.724 -0.143 1 0.526
ALPHAK3ALPHAK3 0.722 -0.095 -1 0.731
FGFR2FGFR2 0.722 -0.099 3 0.738
YANK3YANK3 0.722 -0.077 2 0.381
FGFR1FGFR1 0.720 -0.093 3 0.709
FGRFGR 0.719 -0.187 1 0.493
YES1YES1 0.719 -0.146 -1 0.785
TXKTXK 0.718 -0.106 1 0.445
KITKIT 0.717 -0.156 3 0.742
PDGFRBPDGFRB 0.717 -0.217 3 0.758
KDRKDR 0.717 -0.128 3 0.703
FLT3FLT3 0.717 -0.180 3 0.756
INSRRINSRR 0.717 -0.171 3 0.696
EPHA4EPHA4 0.717 -0.116 2 0.713
PDGFRAPDGFRA 0.714 -0.206 3 0.763
FERFER 0.714 -0.238 1 0.497
LCKLCK 0.714 -0.131 -1 0.728
TEKTEK 0.714 -0.104 3 0.689
AXLAXL 0.714 -0.178 3 0.726
CK1ACK1A 0.713 -0.087 -3 0.286
SRMSSRMS 0.713 -0.201 1 0.468
HCKHCK 0.712 -0.193 -1 0.735
DDR2DDR2 0.712 -0.085 3 0.668
EPHB1EPHB1 0.712 -0.193 1 0.474
MERTKMERTK 0.712 -0.160 3 0.735
STLK3STLK3 0.712 -0.191 1 0.497
ITKITK 0.711 -0.184 -1 0.721
METMET 0.711 -0.149 3 0.746
WEE1_TYRWEE1_TYR 0.711 -0.122 -1 0.709
BLKBLK 0.711 -0.117 -1 0.736
EPHB3EPHB3 0.711 -0.177 -1 0.741
EPHB2EPHB2 0.710 -0.170 -1 0.742
PTK6PTK6 0.709 -0.196 -1 0.681
FGFR3FGFR3 0.709 -0.123 3 0.707
FLT1FLT1 0.708 -0.156 -1 0.757
ALKALK 0.706 -0.196 3 0.657
LTKLTK 0.705 -0.194 3 0.679
ERBB2ERBB2 0.705 -0.193 1 0.496
NTRK1NTRK1 0.705 -0.236 -1 0.757
TECTEC 0.704 -0.181 -1 0.683
FGFR4FGFR4 0.704 -0.102 -1 0.716
EGFREGFR 0.703 -0.113 1 0.430
MATKMATK 0.703 -0.129 -1 0.689
BMXBMX 0.703 -0.165 -1 0.643
FLT4FLT4 0.703 -0.194 3 0.695
EPHA7EPHA7 0.702 -0.163 2 0.711
BTKBTK 0.702 -0.264 -1 0.704
CSKCSK 0.702 -0.149 2 0.717
NTRK3NTRK3 0.702 -0.167 -1 0.705
INSRINSR 0.702 -0.194 3 0.681
EPHA3EPHA3 0.701 -0.178 2 0.685
EPHA1EPHA1 0.700 -0.193 3 0.710
FYNFYN 0.700 -0.149 -1 0.693
NTRK2NTRK2 0.700 -0.246 3 0.699
FRKFRK 0.700 -0.185 -1 0.751
PTK2BPTK2B 0.699 -0.140 -1 0.720
LYNLYN 0.696 -0.194 3 0.666
CK1G3CK1G3 0.696 -0.087 -3 0.238
EPHA5EPHA5 0.695 -0.172 2 0.692
EPHA8EPHA8 0.693 -0.163 -1 0.697
SRCSRC 0.692 -0.184 -1 0.711
PTK2PTK2 0.690 -0.104 -1 0.681
SYKSYK 0.689 -0.124 -1 0.665
IGF1RIGF1R 0.686 -0.178 3 0.618
YANK2YANK2 0.685 -0.108 2 0.396
EPHA2EPHA2 0.685 -0.157 -1 0.675
MUSKMUSK 0.685 -0.188 1 0.412
ERBB4ERBB4 0.684 -0.128 1 0.416
ZAP70ZAP70 0.677 -0.084 -1 0.594
CK1G2CK1G2 0.668 -0.112 -3 0.332
FESFES 0.663 -0.226 -1 0.629