Motif 148 (n=173)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2824 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A1B0GVZ6 | MBD3L2B | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2B | None |
| A1X283 | SH3PXD2B | S720 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A6NE82 | MBD3L3 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) | None |
| A6NF01 | POM121B | S542 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A7E2V4 | ZSWIM8 | S1089 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A7MBM2 | DISP2 | S1263 | ochoa | Protein dispatched homolog 2 | None |
| A7MCY6 | TBKBP1 | S534 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| A8CG34 | POM121C | S935 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00257 | CBX4 | S442 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O14686 | KMT2D | S4822 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S4849 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15018 | PDZD2 | S1953 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15067 | PFAS | S569 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15389 | SIGLEC5 | S490 | ochoa | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| O43150 | ASAP2 | S770 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. |
| O43379 | WDR62 | S1388 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43482 | OIP5 | S48 | ochoa | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| O43572 | AKAP10 | S52 | ochoa | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
| O43586 | PSTPIP1 | S359 | ochoa | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}. |
| O60244 | MED14 | S986 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60292 | SIPA1L3 | S317 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75665 | OFD1 | S844 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O95155 | UBE4B | S31 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95613 | PCNT | S2279 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95677 | EYA4 | S131 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
| P09327 | VIL1 | S747 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P12524 | MYCL | S38 | psp | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | None |
| P13639 | EEF2 | S502 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P14618 | PKM | S37 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P20393 | NR1D1 | S322 | ochoa | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
| P20719 | HOXA5 | S92 | ochoa | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
| P25440 | BRD2 | S253 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27816 | MAP4 | S197 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28715 | ERCC5 | S324 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P32927 | CSF2RB | S665 | ochoa | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P33240 | CSTF2 | S120 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P40425 | PBX2 | S395 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P48634 | PRRC2A | S380 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P53814 | SMTN | S277 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54577 | YARS1 | S338 | ochoa | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}. |
| P55211 | CASP9 | S302 | ochoa | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P55317 | FOXA1 | S355 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P55809 | OXCT1 | S170 | ochoa | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250|UniProtKB:Q29551, ECO:0000269|PubMed:10964512}. |
| P57073 | SOX8 | S327 | ochoa|psp | Transcription factor SOX-8 | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}. |
| P78312 | FAM193A | S1129 | ochoa | Protein FAM193A (Protein IT14) | None |
| Q01167 | FOXK2 | S599 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q04725 | TLE2 | T314 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q07157 | TJP1 | S912 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07617 | SPAG1 | S581 | ochoa | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
| Q07666 | KHDRBS1 | S58 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q07820 | MCL1 | S64 | ochoa|psp | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. |
| Q07889 | SOS1 | S1178 | ochoa|psp | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q12965 | MYO1E | S980 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13228 | SELENBP1 | S371 | ochoa | Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}. |
| Q13233 | MAP3K1 | S137 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q14137 | BOP1 | S573 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14207 | NPAT | S1302 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14814 | MEF2D | S444 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14934 | NFATC4 | S676 | psp | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15345 | LRRC41 | S369 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15678 | PTPN14 | S486 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15699 | ALX1 | S39 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q15717 | ELAVL1 | S221 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15772 | SPEG | S2284 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q3L8U1 | CHD9 | S2303 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q4L180 | FILIP1L | S921 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q5JSZ5 | PRRC2B | S1789 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T8A7 | PPP1R26 | S1127 | ochoa | Protein phosphatase 1 regulatory subunit 26 | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}. |
| Q5THJ4 | VPS13D | S2983 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VST9 | OBSCN | S6817 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VWN6 | TASOR2 | S675 | ochoa | Protein TASOR 2 | None |
| Q5VZK9 | CARMIL1 | S1254 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q684P5 | RAP1GAP2 | S678 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q6AWC2 | WWC2 | S513 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6NYC8 | PPP1R18 | S54 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P2E9 | EDC4 | S676 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PI47 | KCTD18 | S298 | ochoa | BTB/POZ domain-containing protein KCTD18 | None |
| Q6PKG0 | LARP1 | S143 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PL24 | TMED8 | S71 | ochoa | Protein TMED8 | None |
| Q6T310 | RASL11A | S217 | ochoa | Ras-like protein family member 11A (EC 3.6.5.2) | Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). {ECO:0000250}. |
| Q6UXY1 | BAIAP2L2 | S225 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6ZRS2 | SRCAP | S3001 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q76I76 | SSH2 | S618 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7L2J0 | MEPCE | S94 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7L5Y9 | MAEA | S311 | ochoa | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}. |
| Q7Z589 | EMSY | S385 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86VE9 | SERINC5 | S360 | psp | Serine incorporator 5 | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q63175, ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734, ECO:0000269|PubMed:37474505}. |
| Q86X27 | RALGPS2 | S308 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86X51 | EZHIP | S259 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q8IUG5 | MYO18B | S1216 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IXW5 | RPAP2 | S429 | ochoa | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}. |
| Q8IY92 | SLX4 | S1681 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZD2 | KMT2E | S1298 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZT6 | ASPM | S190 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N228 | SCML4 | S274 | ochoa | Sex comb on midleg-like protein 4 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q8N5Y2 | MSL3 | S311 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N612 | FHIP1B | S855 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8N884 | CGAS | S37 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NAP3 | ZBTB38 | S244 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NC42 | RNF149 | S334 | ochoa | E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149) | E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. {ECO:0000269|PubMed:22628551}. |
| Q8NEY1 | NAV1 | S541 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHZ7 | MBD3L2 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2) | May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}. |
| Q8TBA6 | GOLGA5 | S88 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TD19 | NEK9 | S793 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TED9 | AFAP1L1 | S98 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TEM1 | NUP210 | S1860 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8WX93 | PALLD | S641 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WZ75 | ROBO4 | S684 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92466 | DDB2 | S26 | ochoa | DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:32789493, PubMed:9892649). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:14751237, PubMed:16260596, PubMed:32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:16260596). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269|PubMed:10882109, ECO:0000269|PubMed:11278856, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:26572825, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}. |
| Q92547 | TOPBP1 | S888 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92576 | PHF3 | S1362 | ochoa | PHD finger protein 3 | None |
| Q92614 | MYO18A | S164 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92622 | RUBCN | S416 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92786 | PROX1 | S467 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q96B97 | SH3KBP1 | S572 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96HA1 | POM121 | S958 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HC4 | PDLIM5 | S332 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96II8 | LRCH3 | S516 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96IQ9 | ZNF414 | S29 | ochoa | Zinc finger protein 414 | May be involved in transcriptional regulation. |
| Q96IU2 | ZBED3 | S109 | ochoa | Zinc finger BED domain-containing protein 3 (Axin-interacting protein) | Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity). Involved in transcription activation of Wnt target gene expression (By similarity). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity). {ECO:0000250|UniProtKB:Q9D0L1}. |
| Q96JY6 | PDLIM2 | S72 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96N21 | TEPSIN | S356 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96QT6 | PHF12 | S555 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96RG2 | PASK | S849 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RY5 | CRAMP1 | S645 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96S66 | CLCC1 | S509 | ochoa | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q99638 | RAD9A | S277 | ochoa|psp | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}. |
| Q99958 | FOXC2 | S232 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BUL5 | PHF23 | S150 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BWE0 | REPIN1 | S339 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
| Q9BXK1 | KLF16 | S52 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BYT8 | NLN | S598 | ochoa | Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase) | Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P42676}. |
| Q9C0C2 | TNKS1BP1 | S435 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV9 | FGF23 | S207 | psp | Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] | Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}. |
| Q9H165 | BCL11A | S432 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H2D6 | TRIOBP | S1228 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H3P7 | ACBD3 | S20 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H4A3 | WNK1 | S1978 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9HAP2 | MLXIP | S640 | ochoa | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9HBD1 | RC3H2 | S549 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9HC52 | CBX8 | S265 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HC77 | CPAP | S859 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCM7 | FBRSL1 | S830 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NP74 | PALMD | S253 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NQG1 | MANBAL | S55 | ochoa | Protein MANBAL | None |
| Q9NSY0 | NRBP2 | S209 | ochoa | Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) | May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}. |
| Q9NZM4 | BICRA | S755 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P227 | ARHGAP23 | S351 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P243 | ZFAT | S652 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P266 | JCAD | S1235 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P270 | SLAIN2 | S48 | ochoa|psp | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UHF7 | TRPS1 | S127 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UHV7 | MED13 | S504 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UKV3 | ACIN1 | S987 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULI4 | KIF26A | S870 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULM0 | PLEKHH1 | S219 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9UMS6 | SYNPO2 | S611 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UN79 | SOX13 | S371 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPA5 | BSN | S2899 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPQ9 | TNRC6B | S1461 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UQF2 | MAPK8IP1 | S421 | psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y261 | FOXA2 | S436 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y3S1 | WNK2 | S49 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4B5 | MTCL1 | S43 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4B5 | MTCL1 | S1514 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4B6 | DCAF1 | S1328 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4J8 | DTNA | S662 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y4X4 | KLF12 | S92 | ochoa | Krueppel-like factor 12 (Transcriptional repressor AP-2rep) | Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. |
| Q9Y5A9 | YTHDF2 | S218 | ochoa | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:31642031, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}. |
| R4GMW8 | BIVM-ERCC5 | S778 | ochoa | DNA excision repair protein ERCC-5 | None |
| P09382 | LGALS1 | S63 | Sugiyama | Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896). {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:24945728}. |
| P08151 | GLI1 | Y626 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9796292 | Formation of axial mesoderm | 0.001091 | 2.962 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001563 | 2.806 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.004038 | 2.394 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.008828 | 2.054 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.009504 | 2.022 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.009504 | 2.022 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.010945 | 1.961 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.010945 | 1.961 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.011710 | 1.931 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.016938 | 1.771 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.017916 | 1.747 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.016938 | 1.771 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.008828 | 2.054 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.015073 | 1.822 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.007301 | 2.137 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.015073 | 1.822 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.011710 | 1.931 |
| R-HSA-9707616 | Heme signaling | 0.009394 | 2.027 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004038 | 2.394 |
| R-HSA-77108 | Utilization of Ketone Bodies | 0.011817 | 1.928 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.012505 | 1.903 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.009394 | 2.027 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.017916 | 1.747 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.017916 | 1.747 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.017916 | 1.747 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.015990 | 1.796 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.016938 | 1.771 |
| R-HSA-70171 | Glycolysis | 0.010015 | 1.999 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.019966 | 1.700 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.018926 | 1.723 |
| R-HSA-70326 | Glucose metabolism | 0.019103 | 1.719 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.056419 | 1.249 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.056419 | 1.249 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.078089 | 1.107 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.088738 | 1.052 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.088738 | 1.052 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.088738 | 1.052 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.099265 | 1.003 |
| R-HSA-112412 | SOS-mediated signalling | 0.109670 | 0.960 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.119956 | 0.921 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.130124 | 0.886 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.130124 | 0.886 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.130124 | 0.886 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.037240 | 1.429 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.039861 | 1.399 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.039861 | 1.399 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.042550 | 1.371 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.150111 | 0.824 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.045304 | 1.344 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.048123 | 1.318 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.159932 | 0.796 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.159932 | 0.796 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.051004 | 1.292 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.169640 | 0.770 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.056945 | 1.245 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.060002 | 1.222 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 0.179237 | 0.747 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.179237 | 0.747 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.063113 | 1.200 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.188723 | 0.724 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.188723 | 0.724 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.072764 | 1.138 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.198101 | 0.703 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.198101 | 0.703 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.082853 | 1.082 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.216533 | 0.664 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.225591 | 0.647 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.050623 | 1.296 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.050623 | 1.296 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.055919 | 1.252 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.252144 | 0.598 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.252144 | 0.598 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.252144 | 0.598 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.069250 | 1.160 |
| R-HSA-380287 | Centrosome maturation | 0.073300 | 1.135 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.286143 | 0.543 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.104420 | 0.981 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.225296 | 0.647 |
| R-HSA-1989781 | PPARA activates gene expression | 0.143531 | 0.843 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.268043 | 0.572 |
| R-HSA-156902 | Peptide chain elongation | 0.310777 | 0.508 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.086307 | 1.064 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.063113 | 1.200 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.066279 | 1.179 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.086307 | 1.064 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.088275 | 1.054 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.147765 | 0.830 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.109234 | 0.962 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.243395 | 0.614 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.252144 | 0.598 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.277790 | 0.556 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.302562 | 0.519 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.140175 | 0.853 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.159932 | 0.796 |
| R-HSA-111458 | Formation of apoptosome | 0.140175 | 0.853 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.216533 | 0.664 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.104187 | 0.982 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.222898 | 0.652 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.222898 | 0.652 |
| R-HSA-191650 | Regulation of gap junction activity | 0.067317 | 1.172 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.169640 | 0.770 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.216533 | 0.664 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.069250 | 1.160 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.289446 | 0.538 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.222898 | 0.652 |
| R-HSA-4641265 | Repression of WNT target genes | 0.169640 | 0.770 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.126812 | 0.897 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.078089 | 1.107 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.179237 | 0.747 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.188723 | 0.724 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.198101 | 0.703 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.076080 | 1.119 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.119144 | 0.924 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.170776 | 0.768 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.268378 | 0.571 |
| R-HSA-9839394 | TGFBR3 expression | 0.051004 | 1.292 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.056945 | 1.245 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.053945 | 1.268 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.115355 | 0.938 |
| R-HSA-8851805 | MET activates RAS signaling | 0.169640 | 0.770 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.272326 | 0.565 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.310630 | 0.508 |
| R-HSA-74749 | Signal attenuation | 0.140175 | 0.853 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.234544 | 0.630 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.107875 | 0.967 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.331975 | 0.479 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.129307 | 0.888 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.067317 | 1.172 |
| R-HSA-8866376 | Reelin signalling pathway | 0.078089 | 1.107 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.150111 | 0.824 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.150111 | 0.824 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.159932 | 0.796 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.159932 | 0.796 |
| R-HSA-428540 | Activation of RAC1 | 0.159932 | 0.796 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 0.179237 | 0.747 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.024438 | 1.612 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.198101 | 0.703 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.207370 | 0.683 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.216533 | 0.664 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.294400 | 0.531 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.234544 | 0.630 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.071262 | 1.147 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.146458 | 0.834 |
| R-HSA-6807070 | PTEN Regulation | 0.272235 | 0.565 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.034689 | 1.460 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.322611 | 0.491 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.078089 | 1.107 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.234544 | 0.630 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.234544 | 0.630 |
| R-HSA-392517 | Rap1 signalling | 0.243395 | 0.614 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 0.088738 | 1.052 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.140175 | 0.853 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.169640 | 0.770 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 0.260792 | 0.584 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.294400 | 0.531 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.204111 | 0.690 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.233817 | 0.631 |
| R-HSA-2172127 | DAP12 interactions | 0.122963 | 0.910 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.221043 | 0.656 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.078089 | 1.107 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.140175 | 0.853 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.150111 | 0.824 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.179237 | 0.747 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.216533 | 0.664 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.043965 | 1.357 |
| R-HSA-191859 | snRNP Assembly | 0.043965 | 1.357 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.047236 | 1.326 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.092773 | 1.033 |
| R-HSA-112399 | IRS-mediated signalling | 0.174894 | 0.757 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.076080 | 1.119 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.304029 | 0.517 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.139800 | 0.854 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.294400 | 0.531 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.107769 | 0.968 |
| R-HSA-9843745 | Adipogenesis | 0.244287 | 0.612 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 0.234544 | 0.630 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.310630 | 0.508 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.204111 | 0.690 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.331975 | 0.479 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.169640 | 0.770 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.169640 | 0.770 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.198101 | 0.703 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.198101 | 0.703 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.059591 | 1.225 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.143531 | 0.843 |
| R-HSA-177929 | Signaling by EGFR | 0.170776 | 0.768 |
| R-HSA-9909396 | Circadian clock | 0.095105 | 1.022 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.234544 | 0.630 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.208331 | 0.681 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.078089 | 1.107 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.130124 | 0.886 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.051004 | 1.292 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.051004 | 1.292 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.169640 | 0.770 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.198101 | 0.703 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.198101 | 0.703 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.082853 | 1.082 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.089803 | 1.047 |
| R-HSA-429947 | Deadenylation of mRNA | 0.294400 | 0.531 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.191514 | 0.718 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.276609 | 0.558 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.181450 | 0.741 |
| R-HSA-9659379 | Sensory processing of sound | 0.081708 | 1.088 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.179027 | 0.747 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.225591 | 0.647 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.225591 | 0.647 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.243395 | 0.614 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.130689 | 0.884 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.326489 | 0.486 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.088738 | 1.052 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.109670 | 0.960 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.179237 | 0.747 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.025634 | 1.591 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.198101 | 0.703 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.076080 | 1.119 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.260792 | 0.584 |
| R-HSA-167044 | Signalling to RAS | 0.260792 | 0.584 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.067264 | 1.172 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.183175 | 0.737 |
| R-HSA-5693538 | Homology Directed Repair | 0.198961 | 0.701 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.068665 | 1.163 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.310630 | 0.508 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.225591 | 0.647 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.130689 | 0.884 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.277790 | 0.556 |
| R-HSA-68875 | Mitotic Prophase | 0.072080 | 1.142 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.260792 | 0.584 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.260792 | 0.584 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.216533 | 0.664 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.252144 | 0.598 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.269340 | 0.570 |
| R-HSA-68877 | Mitotic Prometaphase | 0.233549 | 0.632 |
| R-HSA-6806834 | Signaling by MET | 0.272326 | 0.565 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.269340 | 0.570 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.145152 | 0.838 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.140175 | 0.853 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.042550 | 1.371 |
| R-HSA-525793 | Myogenesis | 0.053945 | 1.268 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.086307 | 1.064 |
| R-HSA-210993 | Tie2 Signaling | 0.234544 | 0.630 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.170776 | 0.768 |
| R-HSA-68886 | M Phase | 0.190386 | 0.720 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.188723 | 0.724 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.187338 | 0.727 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.175710 | 0.755 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.188723 | 0.724 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.057741 | 1.239 |
| R-HSA-977347 | Serine metabolism | 0.269340 | 0.570 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.170776 | 0.768 |
| R-HSA-168255 | Influenza Infection | 0.199628 | 0.700 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.310630 | 0.508 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.263759 | 0.579 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.205102 | 0.688 |
| R-HSA-9758941 | Gastrulation | 0.131127 | 0.882 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.139345 | 0.856 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.053945 | 1.268 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.169640 | 0.770 |
| R-HSA-8876725 | Protein methylation | 0.198101 | 0.703 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.082853 | 1.082 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.243395 | 0.614 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.269340 | 0.570 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.318605 | 0.497 |
| R-HSA-73894 | DNA Repair | 0.281056 | 0.551 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.119956 | 0.921 |
| R-HSA-9842663 | Signaling by LTK | 0.169640 | 0.770 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.096918 | 1.014 |
| R-HSA-70268 | Pyruvate metabolism | 0.102046 | 0.991 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.216858 | 0.664 |
| R-HSA-74182 | Ketone body metabolism | 0.045304 | 1.344 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.294400 | 0.531 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.246634 | 0.608 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.277790 | 0.556 |
| R-HSA-211000 | Gene Silencing by RNA | 0.051044 | 1.292 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.163579 | 0.786 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.066279 | 1.179 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.286143 | 0.543 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.145152 | 0.838 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.229554 | 0.639 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.263759 | 0.579 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.117257 | 0.931 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.073300 | 1.135 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.086062 | 1.065 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.169640 | 0.770 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.242358 | 0.616 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.161597 | 0.792 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.243395 | 0.614 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.286143 | 0.543 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.196014 | 0.708 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.072764 | 1.138 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.174894 | 0.757 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.161597 | 0.792 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.204111 | 0.690 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.302257 | 0.520 |
| R-HSA-622312 | Inflammasomes | 0.326489 | 0.486 |
| R-HSA-75153 | Apoptotic execution phase | 0.130689 | 0.884 |
| R-HSA-72306 | tRNA processing | 0.178689 | 0.748 |
| R-HSA-3371556 | Cellular response to heat stress | 0.207865 | 0.682 |
| R-HSA-2028269 | Signaling by Hippo | 0.225591 | 0.647 |
| R-HSA-9675135 | Diseases of DNA repair | 0.130689 | 0.884 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.284772 | 0.546 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.322611 | 0.491 |
| R-HSA-9610379 | HCMV Late Events | 0.332092 | 0.479 |
| R-HSA-162587 | HIV Life Cycle | 0.332092 | 0.479 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.334281 | 0.476 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.334281 | 0.476 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.334281 | 0.476 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.334281 | 0.476 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.334281 | 0.476 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.334281 | 0.476 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.335802 | 0.474 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.336194 | 0.473 |
| R-HSA-1640170 | Cell Cycle | 0.340928 | 0.467 |
| R-HSA-2424491 | DAP12 signaling | 0.341984 | 0.466 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.341984 | 0.466 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.341984 | 0.466 |
| R-HSA-109581 | Apoptosis | 0.347882 | 0.459 |
| R-HSA-182971 | EGFR downregulation | 0.349599 | 0.456 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.349599 | 0.456 |
| R-HSA-186763 | Downstream signal transduction | 0.349599 | 0.456 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.361331 | 0.442 |
| R-HSA-190236 | Signaling by FGFR | 0.361331 | 0.442 |
| R-HSA-5619102 | SLC transporter disorders | 0.363637 | 0.439 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.364566 | 0.438 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.364566 | 0.438 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.364566 | 0.438 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.364566 | 0.438 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.364566 | 0.438 |
| R-HSA-354192 | Integrin signaling | 0.364566 | 0.438 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.365488 | 0.437 |
| R-HSA-390522 | Striated Muscle Contraction | 0.371920 | 0.430 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.371920 | 0.430 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.371920 | 0.430 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.379190 | 0.421 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.379190 | 0.421 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.379190 | 0.421 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.379190 | 0.421 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.379190 | 0.421 |
| R-HSA-4839726 | Chromatin organization | 0.380717 | 0.419 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.385591 | 0.414 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.385591 | 0.414 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.386376 | 0.413 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.386376 | 0.413 |
| R-HSA-187687 | Signalling to ERKs | 0.386376 | 0.413 |
| R-HSA-9833110 | RSV-host interactions | 0.390201 | 0.409 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.391834 | 0.407 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.393479 | 0.405 |
| R-HSA-8853659 | RET signaling | 0.393479 | 0.405 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.394280 | 0.404 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.406440 | 0.391 |
| R-HSA-2559583 | Cellular Senescence | 0.407370 | 0.390 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.411359 | 0.386 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.416636 | 0.380 |
| R-HSA-9646399 | Aggrephagy | 0.421083 | 0.376 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.422469 | 0.374 |
| R-HSA-69275 | G2/M Transition | 0.425856 | 0.371 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.427316 | 0.369 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.427787 | 0.369 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.427787 | 0.369 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.427787 | 0.369 |
| R-HSA-9607240 | FLT3 Signaling | 0.427787 | 0.369 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.430294 | 0.366 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.431975 | 0.365 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.434345 | 0.362 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.434413 | 0.362 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.434413 | 0.362 |
| R-HSA-5617833 | Cilium Assembly | 0.438070 | 0.358 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.440963 | 0.356 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.440963 | 0.356 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.447438 | 0.349 |
| R-HSA-5683826 | Surfactant metabolism | 0.453838 | 0.343 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.453845 | 0.343 |
| R-HSA-9609690 | HCMV Early Events | 0.456207 | 0.341 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.456207 | 0.341 |
| R-HSA-774815 | Nucleosome assembly | 0.460164 | 0.337 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.460164 | 0.337 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.460164 | 0.337 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.460164 | 0.337 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.466418 | 0.331 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.466418 | 0.331 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.472957 | 0.325 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.477053 | 0.321 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.478709 | 0.320 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.484749 | 0.314 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.484749 | 0.314 |
| R-HSA-5357801 | Programmed Cell Death | 0.485875 | 0.313 |
| R-HSA-109704 | PI3K Cascade | 0.490719 | 0.309 |
| R-HSA-69481 | G2/M Checkpoints | 0.491665 | 0.308 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.495356 | 0.305 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.496620 | 0.304 |
| R-HSA-72187 | mRNA 3'-end processing | 0.502453 | 0.299 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.502453 | 0.299 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.502453 | 0.299 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.502453 | 0.299 |
| R-HSA-9679506 | SARS-CoV Infections | 0.504935 | 0.297 |
| R-HSA-195721 | Signaling by WNT | 0.505798 | 0.296 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.508219 | 0.294 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.508219 | 0.294 |
| R-HSA-418990 | Adherens junctions interactions | 0.523251 | 0.281 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.524950 | 0.280 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.525122 | 0.280 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.531324 | 0.275 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.534824 | 0.272 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.536067 | 0.271 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.536067 | 0.271 |
| R-HSA-8953854 | Metabolism of RNA | 0.537849 | 0.269 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.541446 | 0.266 |
| R-HSA-186712 | Regulation of beta-cell development | 0.541446 | 0.266 |
| R-HSA-983189 | Kinesins | 0.546762 | 0.262 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.546762 | 0.262 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.546762 | 0.262 |
| R-HSA-379724 | tRNA Aminoacylation | 0.546762 | 0.262 |
| R-HSA-162906 | HIV Infection | 0.548246 | 0.261 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.552017 | 0.258 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.557212 | 0.254 |
| R-HSA-186797 | Signaling by PDGF | 0.557212 | 0.254 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.562347 | 0.250 |
| R-HSA-8848021 | Signaling by PTK6 | 0.562347 | 0.250 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.562347 | 0.250 |
| R-HSA-166520 | Signaling by NTRKs | 0.575423 | 0.240 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.581935 | 0.235 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.582299 | 0.235 |
| R-HSA-9830369 | Kidney development | 0.582299 | 0.235 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.588374 | 0.230 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.588374 | 0.230 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.588374 | 0.230 |
| R-HSA-73887 | Death Receptor Signaling | 0.594739 | 0.226 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.596668 | 0.224 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.596668 | 0.224 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.600959 | 0.221 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.605973 | 0.218 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.605973 | 0.218 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.605973 | 0.218 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.605973 | 0.218 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.607249 | 0.217 |
| R-HSA-9609646 | HCMV Infection | 0.608513 | 0.216 |
| R-HSA-4086398 | Ca2+ pathway | 0.610545 | 0.214 |
| R-HSA-421270 | Cell-cell junction organization | 0.611009 | 0.214 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.613395 | 0.212 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.613395 | 0.212 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.615064 | 0.211 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.618600 | 0.209 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.619531 | 0.208 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.619531 | 0.208 |
| R-HSA-5689603 | UCH proteinases | 0.623946 | 0.205 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.623946 | 0.205 |
| R-HSA-449147 | Signaling by Interleukins | 0.626310 | 0.203 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.628311 | 0.202 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.632625 | 0.199 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.636889 | 0.196 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.640139 | 0.194 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.641104 | 0.193 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.645886 | 0.190 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.650325 | 0.187 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.653460 | 0.185 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.661461 | 0.179 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.661461 | 0.179 |
| R-HSA-2262752 | Cellular responses to stress | 0.666795 | 0.176 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.669278 | 0.174 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.669278 | 0.174 |
| R-HSA-446728 | Cell junction organization | 0.674369 | 0.171 |
| R-HSA-9663891 | Selective autophagy | 0.676916 | 0.169 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.688045 | 0.162 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.688045 | 0.162 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.688045 | 0.162 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.691669 | 0.160 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.694365 | 0.158 |
| R-HSA-983712 | Ion channel transport | 0.696892 | 0.157 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.697920 | 0.156 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.702292 | 0.153 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.702292 | 0.153 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.704368 | 0.152 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.705752 | 0.151 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.705752 | 0.151 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.709171 | 0.149 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.709171 | 0.149 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.709171 | 0.149 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.709281 | 0.149 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.712228 | 0.147 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.712551 | 0.147 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.712551 | 0.147 |
| R-HSA-74160 | Gene expression (Transcription) | 0.712556 | 0.147 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.715892 | 0.145 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.719194 | 0.143 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.719194 | 0.143 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.719194 | 0.143 |
| R-HSA-3214847 | HATs acetylate histones | 0.722458 | 0.141 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.723562 | 0.141 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.728874 | 0.137 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.730485 | 0.136 |
| R-HSA-192823 | Viral mRNA Translation | 0.735142 | 0.134 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.738222 | 0.132 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.738222 | 0.132 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.741266 | 0.130 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.741266 | 0.130 |
| R-HSA-212436 | Generic Transcription Pathway | 0.746499 | 0.127 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.750188 | 0.125 |
| R-HSA-1500931 | Cell-Cell communication | 0.750244 | 0.125 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.753094 | 0.123 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.753094 | 0.123 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.753094 | 0.123 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.753094 | 0.123 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.755966 | 0.121 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.755966 | 0.121 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.762569 | 0.118 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.764384 | 0.117 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.764384 | 0.117 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.767126 | 0.115 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.767126 | 0.115 |
| R-HSA-8951664 | Neddylation | 0.771002 | 0.113 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.775161 | 0.111 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.775161 | 0.111 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.777778 | 0.109 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.780364 | 0.108 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.780364 | 0.108 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.787945 | 0.104 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.787945 | 0.104 |
| R-HSA-72312 | rRNA processing | 0.791964 | 0.101 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.792020 | 0.101 |
| R-HSA-73886 | Chromosome Maintenance | 0.792853 | 0.101 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.795265 | 0.099 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.795265 | 0.099 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.795590 | 0.099 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.797649 | 0.098 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.797649 | 0.098 |
| R-HSA-8939211 | ESR-mediated signaling | 0.800924 | 0.096 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.801801 | 0.096 |
| R-HSA-157118 | Signaling by NOTCH | 0.806134 | 0.094 |
| R-HSA-6798695 | Neutrophil degranulation | 0.808242 | 0.092 |
| R-HSA-114608 | Platelet degranulation | 0.809161 | 0.092 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.815752 | 0.088 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.822118 | 0.085 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.823953 | 0.084 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.824190 | 0.084 |
| R-HSA-5688426 | Deubiquitination | 0.830416 | 0.081 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.832244 | 0.080 |
| R-HSA-1266738 | Developmental Biology | 0.834351 | 0.079 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.834933 | 0.078 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.836132 | 0.078 |
| R-HSA-1632852 | Macroautophagy | 0.841797 | 0.075 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.847267 | 0.072 |
| R-HSA-913531 | Interferon Signaling | 0.850282 | 0.070 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.855968 | 0.068 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.857242 | 0.067 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.859309 | 0.066 |
| R-HSA-9824446 | Viral Infection Pathways | 0.864396 | 0.063 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.867337 | 0.062 |
| R-HSA-9612973 | Autophagy | 0.868876 | 0.061 |
| R-HSA-9711097 | Cellular response to starvation | 0.871919 | 0.060 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.880633 | 0.055 |
| R-HSA-199991 | Membrane Trafficking | 0.891422 | 0.050 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.892611 | 0.049 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.893865 | 0.049 |
| R-HSA-72766 | Translation | 0.896443 | 0.047 |
| R-HSA-422475 | Axon guidance | 0.897246 | 0.047 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.908909 | 0.041 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.914113 | 0.039 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.917092 | 0.038 |
| R-HSA-9675108 | Nervous system development | 0.922281 | 0.035 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.922745 | 0.035 |
| R-HSA-72172 | mRNA Splicing | 0.927162 | 0.033 |
| R-HSA-1280218 | Adaptive Immune System | 0.932881 | 0.030 |
| R-HSA-397014 | Muscle contraction | 0.933712 | 0.030 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.934489 | 0.029 |
| R-HSA-68882 | Mitotic Anaphase | 0.936764 | 0.028 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.937505 | 0.028 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.938366 | 0.028 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.938911 | 0.027 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.945751 | 0.024 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.949784 | 0.022 |
| R-HSA-15869 | Metabolism of nucleotides | 0.950051 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.950637 | 0.022 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.953122 | 0.021 |
| R-HSA-109582 | Hemostasis | 0.959399 | 0.018 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.960557 | 0.017 |
| R-HSA-168256 | Immune System | 0.962025 | 0.017 |
| R-HSA-416476 | G alpha (q) signalling events | 0.964115 | 0.016 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.965773 | 0.015 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.966239 | 0.015 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.970652 | 0.013 |
| R-HSA-9658195 | Leishmania infection | 0.970652 | 0.013 |
| R-HSA-162582 | Signal Transduction | 0.971578 | 0.013 |
| R-HSA-168249 | Innate Immune System | 0.978241 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 0.982369 | 0.008 |
| R-HSA-5663205 | Infectious disease | 0.982407 | 0.008 |
| R-HSA-1474244 | Extracellular matrix organization | 0.983774 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 0.989447 | 0.005 |
| R-HSA-1643685 | Disease | 0.990093 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 0.992301 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.992422 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 0.993510 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.994888 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995508 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.995546 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.996870 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.998731 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999269 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999710 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999919 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999965 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.861 | 0.776 | 1 | 0.900 |
JNK2 |
0.857 | 0.871 | 1 | 0.893 |
P38G |
0.856 | 0.851 | 1 | 0.916 |
CDK19 |
0.855 | 0.800 | 1 | 0.883 |
KIS |
0.855 | 0.736 | 1 | 0.854 |
CDK18 |
0.853 | 0.805 | 1 | 0.905 |
P38D |
0.852 | 0.837 | 1 | 0.932 |
CDK8 |
0.850 | 0.798 | 1 | 0.862 |
CDK3 |
0.850 | 0.733 | 1 | 0.915 |
CDK7 |
0.849 | 0.791 | 1 | 0.876 |
CDK1 |
0.849 | 0.793 | 1 | 0.891 |
DYRK2 |
0.848 | 0.757 | 1 | 0.840 |
JNK3 |
0.847 | 0.854 | 1 | 0.883 |
CDK17 |
0.847 | 0.812 | 1 | 0.914 |
ERK1 |
0.846 | 0.806 | 1 | 0.881 |
CDK13 |
0.846 | 0.802 | 1 | 0.890 |
HIPK4 |
0.844 | 0.549 | 1 | 0.678 |
P38B |
0.844 | 0.812 | 1 | 0.871 |
CDK12 |
0.843 | 0.802 | 1 | 0.900 |
DYRK4 |
0.841 | 0.754 | 1 | 0.905 |
CDK5 |
0.841 | 0.766 | 1 | 0.859 |
CLK3 |
0.841 | 0.518 | 1 | 0.643 |
HIPK1 |
0.840 | 0.708 | 1 | 0.826 |
CDK16 |
0.839 | 0.773 | 1 | 0.912 |
P38A |
0.835 | 0.783 | 1 | 0.827 |
CDK9 |
0.834 | 0.779 | 1 | 0.883 |
DYRK1B |
0.834 | 0.725 | 1 | 0.871 |
CDK10 |
0.833 | 0.740 | 1 | 0.888 |
SRPK1 |
0.832 | 0.404 | -3 | 0.737 |
JNK1 |
0.830 | 0.763 | 1 | 0.896 |
CDK14 |
0.830 | 0.765 | 1 | 0.874 |
ERK2 |
0.828 | 0.786 | 1 | 0.858 |
DYRK1A |
0.827 | 0.626 | 1 | 0.808 |
NLK |
0.827 | 0.709 | 1 | 0.664 |
HIPK3 |
0.827 | 0.686 | 1 | 0.789 |
CDK4 |
0.824 | 0.779 | 1 | 0.908 |
CLK2 |
0.823 | 0.444 | -3 | 0.723 |
CDK6 |
0.821 | 0.752 | 1 | 0.886 |
ERK5 |
0.819 | 0.409 | 1 | 0.582 |
MAK |
0.818 | 0.535 | -2 | 0.741 |
SRPK2 |
0.817 | 0.325 | -3 | 0.669 |
DYRK3 |
0.817 | 0.553 | 1 | 0.794 |
CLK1 |
0.815 | 0.440 | -3 | 0.715 |
CDK2 |
0.815 | 0.599 | 1 | 0.793 |
ICK |
0.812 | 0.397 | -3 | 0.793 |
CLK4 |
0.811 | 0.395 | -3 | 0.730 |
CDKL5 |
0.811 | 0.219 | -3 | 0.768 |
MTOR |
0.809 | 0.237 | 1 | 0.458 |
COT |
0.807 | -0.040 | 2 | 0.840 |
CDKL1 |
0.807 | 0.199 | -3 | 0.770 |
MOK |
0.806 | 0.501 | 1 | 0.740 |
SRPK3 |
0.803 | 0.284 | -3 | 0.705 |
CDC7 |
0.800 | -0.050 | 1 | 0.332 |
MOS |
0.798 | 0.012 | 1 | 0.379 |
PRP4 |
0.797 | 0.439 | -3 | 0.675 |
PRKD1 |
0.797 | 0.053 | -3 | 0.778 |
CHAK2 |
0.795 | 0.032 | -1 | 0.877 |
PIM3 |
0.795 | 0.004 | -3 | 0.779 |
PRPK |
0.794 | -0.058 | -1 | 0.845 |
PRKD2 |
0.793 | 0.055 | -3 | 0.733 |
ATR |
0.792 | -0.011 | 1 | 0.384 |
NDR2 |
0.790 | -0.011 | -3 | 0.765 |
RSK2 |
0.790 | 0.034 | -3 | 0.747 |
CAMK1B |
0.790 | -0.002 | -3 | 0.800 |
WNK1 |
0.789 | -0.035 | -2 | 0.830 |
MAPKAPK2 |
0.788 | 0.035 | -3 | 0.698 |
NUAK2 |
0.786 | 0.026 | -3 | 0.777 |
TBK1 |
0.786 | -0.159 | 1 | 0.246 |
ERK7 |
0.786 | 0.255 | 2 | 0.504 |
PKN3 |
0.786 | -0.022 | -3 | 0.761 |
SKMLCK |
0.786 | -0.028 | -2 | 0.779 |
IKKB |
0.786 | -0.143 | -2 | 0.662 |
MST4 |
0.786 | -0.029 | 2 | 0.826 |
MAPKAPK3 |
0.786 | 0.006 | -3 | 0.732 |
P90RSK |
0.785 | 0.029 | -3 | 0.750 |
RAF1 |
0.785 | -0.179 | 1 | 0.302 |
PIM1 |
0.785 | 0.050 | -3 | 0.736 |
NEK6 |
0.785 | -0.067 | -2 | 0.722 |
ULK2 |
0.785 | -0.167 | 2 | 0.771 |
GCN2 |
0.785 | -0.197 | 2 | 0.782 |
AURC |
0.784 | 0.020 | -2 | 0.560 |
PKCD |
0.784 | -0.006 | 2 | 0.755 |
DSTYK |
0.784 | -0.127 | 2 | 0.843 |
PDHK4 |
0.783 | -0.181 | 1 | 0.370 |
NIK |
0.782 | -0.045 | -3 | 0.795 |
RSK3 |
0.782 | 0.010 | -3 | 0.743 |
IKKE |
0.782 | -0.166 | 1 | 0.243 |
BMPR2 |
0.782 | -0.196 | -2 | 0.767 |
AMPKA1 |
0.782 | -0.035 | -3 | 0.779 |
NDR1 |
0.782 | -0.045 | -3 | 0.764 |
GRK1 |
0.781 | -0.017 | -2 | 0.703 |
CAMLCK |
0.781 | -0.013 | -2 | 0.747 |
PKN2 |
0.780 | -0.051 | -3 | 0.761 |
CAMK2G |
0.779 | -0.104 | 2 | 0.764 |
MARK4 |
0.779 | -0.061 | 4 | 0.778 |
IKKA |
0.779 | -0.077 | -2 | 0.654 |
DAPK2 |
0.778 | -0.028 | -3 | 0.801 |
PRKD3 |
0.778 | 0.031 | -3 | 0.721 |
GRK7 |
0.778 | 0.024 | 1 | 0.322 |
TSSK1 |
0.778 | -0.021 | -3 | 0.798 |
PDHK1 |
0.778 | -0.184 | 1 | 0.341 |
AMPKA2 |
0.778 | -0.017 | -3 | 0.755 |
P70S6KB |
0.777 | 0.001 | -3 | 0.749 |
LATS2 |
0.777 | -0.034 | -5 | 0.764 |
HUNK |
0.776 | -0.133 | 2 | 0.796 |
PKACG |
0.776 | -0.029 | -2 | 0.621 |
NEK7 |
0.776 | -0.172 | -3 | 0.763 |
MPSK1 |
0.776 | 0.087 | 1 | 0.377 |
MLK2 |
0.776 | -0.101 | 2 | 0.804 |
PKCB |
0.776 | -0.011 | 2 | 0.706 |
IRE1 |
0.776 | -0.079 | 1 | 0.323 |
NIM1 |
0.775 | -0.059 | 3 | 0.706 |
ULK1 |
0.775 | -0.160 | -3 | 0.723 |
CAMK2D |
0.775 | -0.068 | -3 | 0.773 |
PKACB |
0.775 | 0.026 | -2 | 0.562 |
RIPK3 |
0.775 | -0.162 | 3 | 0.674 |
PAK1 |
0.775 | -0.038 | -2 | 0.699 |
TSSK2 |
0.775 | -0.061 | -5 | 0.842 |
AKT2 |
0.775 | 0.059 | -3 | 0.676 |
MNK2 |
0.774 | -0.028 | -2 | 0.693 |
GRK5 |
0.774 | -0.160 | -3 | 0.749 |
MLK1 |
0.774 | -0.170 | 2 | 0.784 |
PAK6 |
0.774 | 0.005 | -2 | 0.618 |
DNAPK |
0.774 | -0.011 | 1 | 0.340 |
PINK1 |
0.773 | 0.175 | 1 | 0.523 |
RSK4 |
0.773 | 0.024 | -3 | 0.712 |
GSK3A |
0.773 | 0.183 | 4 | 0.412 |
PRKX |
0.772 | 0.046 | -3 | 0.646 |
MLK3 |
0.772 | -0.070 | 2 | 0.710 |
PKCA |
0.772 | -0.020 | 2 | 0.699 |
BMPR1B |
0.772 | -0.047 | 1 | 0.282 |
LATS1 |
0.771 | 0.003 | -3 | 0.777 |
PAK3 |
0.771 | -0.067 | -2 | 0.695 |
TGFBR2 |
0.771 | -0.143 | -2 | 0.631 |
WNK3 |
0.771 | -0.209 | 1 | 0.309 |
SMG1 |
0.771 | -0.040 | 1 | 0.369 |
SGK3 |
0.771 | 0.020 | -3 | 0.721 |
NEK9 |
0.771 | -0.167 | 2 | 0.818 |
RIPK1 |
0.771 | -0.174 | 1 | 0.308 |
PKCZ |
0.771 | -0.031 | 2 | 0.757 |
MNK1 |
0.770 | -0.018 | -2 | 0.695 |
ATM |
0.770 | -0.068 | 1 | 0.347 |
NUAK1 |
0.770 | -0.030 | -3 | 0.735 |
MELK |
0.770 | -0.052 | -3 | 0.747 |
PKCG |
0.770 | -0.037 | 2 | 0.702 |
PKR |
0.770 | -0.066 | 1 | 0.344 |
GRK6 |
0.770 | -0.123 | 1 | 0.302 |
VRK2 |
0.769 | 0.050 | 1 | 0.415 |
BCKDK |
0.769 | -0.170 | -1 | 0.760 |
QSK |
0.769 | -0.033 | 4 | 0.755 |
MASTL |
0.768 | -0.195 | -2 | 0.712 |
CAMK2A |
0.768 | -0.014 | 2 | 0.743 |
MSK2 |
0.768 | -0.027 | -3 | 0.718 |
CHAK1 |
0.767 | -0.105 | 2 | 0.776 |
DLK |
0.767 | -0.212 | 1 | 0.309 |
ALK4 |
0.766 | -0.082 | -2 | 0.702 |
IRE2 |
0.766 | -0.095 | 2 | 0.739 |
TGFBR1 |
0.766 | -0.072 | -2 | 0.676 |
CAMK2B |
0.765 | -0.051 | 2 | 0.731 |
PKG2 |
0.765 | -0.021 | -2 | 0.570 |
AURB |
0.765 | -0.030 | -2 | 0.546 |
PHKG1 |
0.765 | -0.071 | -3 | 0.753 |
NEK2 |
0.765 | -0.110 | 2 | 0.797 |
DCAMKL1 |
0.765 | -0.009 | -3 | 0.732 |
MSK1 |
0.765 | -0.012 | -3 | 0.718 |
PIM2 |
0.763 | 0.032 | -3 | 0.719 |
PKCH |
0.763 | -0.060 | 2 | 0.696 |
TTBK2 |
0.763 | -0.187 | 2 | 0.689 |
SIK |
0.762 | -0.039 | -3 | 0.709 |
QIK |
0.762 | -0.108 | -3 | 0.762 |
AKT1 |
0.762 | 0.025 | -3 | 0.683 |
ANKRD3 |
0.761 | -0.224 | 1 | 0.326 |
TLK2 |
0.761 | -0.113 | 1 | 0.309 |
FAM20C |
0.761 | -0.037 | 2 | 0.562 |
CAMK4 |
0.761 | -0.135 | -3 | 0.741 |
WNK4 |
0.759 | -0.085 | -2 | 0.822 |
PAK2 |
0.759 | -0.092 | -2 | 0.674 |
MAPKAPK5 |
0.759 | -0.053 | -3 | 0.691 |
BRSK1 |
0.759 | -0.062 | -3 | 0.739 |
MEK1 |
0.758 | -0.164 | 2 | 0.826 |
YSK4 |
0.758 | -0.183 | 1 | 0.268 |
MARK3 |
0.758 | -0.058 | 4 | 0.700 |
PKACA |
0.757 | 0.006 | -2 | 0.520 |
PKCT |
0.757 | -0.046 | 2 | 0.706 |
MLK4 |
0.757 | -0.134 | 2 | 0.694 |
GRK4 |
0.757 | -0.198 | -2 | 0.708 |
CHK1 |
0.757 | -0.072 | -3 | 0.754 |
BRSK2 |
0.757 | -0.097 | -3 | 0.748 |
LKB1 |
0.756 | 0.012 | -3 | 0.735 |
IRAK4 |
0.756 | -0.112 | 1 | 0.303 |
SBK |
0.756 | 0.151 | -3 | 0.583 |
SSTK |
0.756 | -0.043 | 4 | 0.736 |
GSK3B |
0.756 | 0.036 | 4 | 0.404 |
MST3 |
0.756 | -0.060 | 2 | 0.812 |
MYLK4 |
0.756 | -0.056 | -2 | 0.670 |
PLK1 |
0.755 | -0.177 | -2 | 0.629 |
CAMK1G |
0.755 | -0.047 | -3 | 0.717 |
NEK5 |
0.754 | -0.118 | 1 | 0.315 |
MARK2 |
0.754 | -0.078 | 4 | 0.677 |
AKT3 |
0.754 | 0.045 | -3 | 0.629 |
ACVR2B |
0.754 | -0.125 | -2 | 0.644 |
ALK2 |
0.753 | -0.109 | -2 | 0.681 |
PLK4 |
0.753 | -0.136 | 2 | 0.631 |
PASK |
0.753 | -0.027 | -3 | 0.785 |
TAO3 |
0.753 | -0.055 | 1 | 0.320 |
AURA |
0.753 | -0.058 | -2 | 0.514 |
PKCI |
0.753 | -0.033 | 2 | 0.719 |
BRAF |
0.753 | -0.120 | -4 | 0.833 |
BUB1 |
0.752 | 0.042 | -5 | 0.760 |
DCAMKL2 |
0.752 | -0.046 | -3 | 0.754 |
MEKK2 |
0.752 | -0.131 | 2 | 0.788 |
SGK1 |
0.751 | 0.060 | -3 | 0.612 |
PDK1 |
0.751 | -0.031 | 1 | 0.335 |
ACVR2A |
0.751 | -0.140 | -2 | 0.631 |
CK1E |
0.751 | -0.052 | -3 | 0.449 |
PKCE |
0.751 | 0.000 | 2 | 0.692 |
MEK5 |
0.750 | -0.187 | 2 | 0.807 |
PAK5 |
0.750 | -0.043 | -2 | 0.539 |
MEKK1 |
0.750 | -0.178 | 1 | 0.304 |
DRAK1 |
0.750 | -0.160 | 1 | 0.270 |
P70S6K |
0.750 | -0.022 | -3 | 0.683 |
SNRK |
0.749 | -0.170 | 2 | 0.670 |
PERK |
0.749 | -0.182 | -2 | 0.694 |
GRK2 |
0.749 | -0.113 | -2 | 0.612 |
ZAK |
0.749 | -0.181 | 1 | 0.274 |
GAK |
0.749 | -0.030 | 1 | 0.367 |
PAK4 |
0.749 | -0.029 | -2 | 0.544 |
BMPR1A |
0.749 | -0.084 | 1 | 0.265 |
PHKG2 |
0.748 | -0.090 | -3 | 0.729 |
PLK3 |
0.747 | -0.152 | 2 | 0.730 |
MEKK6 |
0.747 | -0.075 | 1 | 0.299 |
PKN1 |
0.747 | -0.017 | -3 | 0.696 |
HASPIN |
0.747 | 0.064 | -1 | 0.771 |
PBK |
0.746 | -0.003 | 1 | 0.333 |
MARK1 |
0.746 | -0.108 | 4 | 0.717 |
TNIK |
0.746 | -0.020 | 3 | 0.851 |
MAP3K15 |
0.746 | -0.077 | 1 | 0.283 |
CAMK1D |
0.746 | -0.024 | -3 | 0.665 |
MEKK3 |
0.746 | -0.205 | 1 | 0.294 |
CAMKK1 |
0.745 | -0.144 | -2 | 0.699 |
SMMLCK |
0.745 | -0.057 | -3 | 0.764 |
CAMKK2 |
0.744 | -0.103 | -2 | 0.696 |
HRI |
0.744 | -0.222 | -2 | 0.706 |
HGK |
0.744 | -0.057 | 3 | 0.845 |
TLK1 |
0.744 | -0.179 | -2 | 0.692 |
TAO2 |
0.744 | -0.085 | 2 | 0.819 |
NEK11 |
0.743 | -0.151 | 1 | 0.305 |
CK2A2 |
0.742 | -0.039 | 1 | 0.258 |
MRCKB |
0.742 | 0.005 | -3 | 0.696 |
NEK4 |
0.742 | -0.131 | 1 | 0.286 |
GCK |
0.742 | -0.084 | 1 | 0.296 |
LRRK2 |
0.742 | -0.026 | 2 | 0.819 |
KHS1 |
0.742 | -0.027 | 1 | 0.290 |
ROCK2 |
0.741 | 0.002 | -3 | 0.731 |
CK1D |
0.741 | -0.038 | -3 | 0.395 |
DAPK3 |
0.741 | -0.041 | -3 | 0.744 |
MINK |
0.741 | -0.100 | 1 | 0.275 |
CHK2 |
0.741 | 0.005 | -3 | 0.627 |
NEK8 |
0.740 | -0.177 | 2 | 0.792 |
KHS2 |
0.740 | -0.007 | 1 | 0.303 |
HPK1 |
0.739 | -0.073 | 1 | 0.293 |
NEK1 |
0.738 | -0.116 | 1 | 0.290 |
CK1G1 |
0.738 | -0.097 | -3 | 0.441 |
LOK |
0.738 | -0.079 | -2 | 0.657 |
EEF2K |
0.737 | -0.084 | 3 | 0.824 |
MRCKA |
0.735 | -0.020 | -3 | 0.704 |
CAMK1A |
0.735 | -0.013 | -3 | 0.637 |
CK1A2 |
0.735 | -0.067 | -3 | 0.400 |
DAPK1 |
0.734 | -0.045 | -3 | 0.733 |
TAK1 |
0.734 | -0.169 | 1 | 0.294 |
DMPK1 |
0.733 | 0.024 | -3 | 0.713 |
CK2A1 |
0.733 | -0.051 | 1 | 0.247 |
GRK3 |
0.733 | -0.118 | -2 | 0.567 |
VRK1 |
0.733 | -0.164 | 2 | 0.826 |
PDHK3_TYR |
0.732 | 0.174 | 4 | 0.854 |
TTBK1 |
0.732 | -0.192 | 2 | 0.601 |
CRIK |
0.732 | 0.032 | -3 | 0.688 |
MST2 |
0.732 | -0.174 | 1 | 0.284 |
STK33 |
0.731 | -0.122 | 2 | 0.591 |
SLK |
0.731 | -0.088 | -2 | 0.593 |
IRAK1 |
0.731 | -0.246 | -1 | 0.733 |
YSK1 |
0.730 | -0.117 | 2 | 0.787 |
LIMK2_TYR |
0.729 | 0.163 | -3 | 0.801 |
NEK3 |
0.728 | -0.107 | 1 | 0.292 |
PKG1 |
0.727 | -0.043 | -2 | 0.503 |
BIKE |
0.726 | -0.024 | 1 | 0.336 |
ROCK1 |
0.726 | -0.018 | -3 | 0.702 |
PLK2 |
0.725 | -0.089 | -3 | 0.723 |
MST1 |
0.724 | -0.181 | 1 | 0.274 |
AAK1 |
0.723 | 0.020 | 1 | 0.323 |
MEK2 |
0.723 | -0.209 | 2 | 0.809 |
TESK1_TYR |
0.722 | 0.032 | 3 | 0.836 |
MYO3B |
0.722 | -0.067 | 2 | 0.807 |
PKMYT1_TYR |
0.722 | 0.116 | 3 | 0.801 |
ASK1 |
0.722 | -0.108 | 1 | 0.280 |
OSR1 |
0.721 | -0.095 | 2 | 0.785 |
PDHK4_TYR |
0.720 | 0.030 | 2 | 0.845 |
MAP2K4_TYR |
0.719 | 0.014 | -1 | 0.852 |
RIPK2 |
0.716 | -0.256 | 1 | 0.248 |
MAP2K6_TYR |
0.716 | -0.001 | -1 | 0.861 |
TAO1 |
0.715 | -0.108 | 1 | 0.271 |
ALPHAK3 |
0.715 | -0.093 | -1 | 0.753 |
MYO3A |
0.714 | -0.105 | 1 | 0.304 |
MAP2K7_TYR |
0.714 | -0.115 | 2 | 0.831 |
BMPR2_TYR |
0.713 | -0.008 | -1 | 0.853 |
PDHK1_TYR |
0.712 | -0.065 | -1 | 0.863 |
PINK1_TYR |
0.711 | -0.139 | 1 | 0.368 |
LIMK1_TYR |
0.710 | -0.023 | 2 | 0.831 |
TTK |
0.709 | -0.162 | -2 | 0.653 |
YANK3 |
0.707 | -0.083 | 2 | 0.372 |
RET |
0.703 | -0.179 | 1 | 0.323 |
NEK10_TYR |
0.702 | -0.089 | 1 | 0.286 |
MST1R |
0.702 | -0.147 | 3 | 0.742 |
EPHA6 |
0.702 | -0.117 | -1 | 0.814 |
JAK2 |
0.701 | -0.152 | 1 | 0.322 |
CSF1R |
0.701 | -0.123 | 3 | 0.730 |
CK1A |
0.701 | -0.084 | -3 | 0.312 |
TNNI3K_TYR |
0.700 | -0.043 | 1 | 0.332 |
ROS1 |
0.700 | -0.163 | 3 | 0.709 |
TYK2 |
0.699 | -0.236 | 1 | 0.308 |
TNK1 |
0.699 | -0.066 | 3 | 0.723 |
ABL2 |
0.698 | -0.120 | -1 | 0.757 |
TYRO3 |
0.697 | -0.195 | 3 | 0.740 |
EPHB4 |
0.697 | -0.156 | -1 | 0.778 |
STLK3 |
0.696 | -0.209 | 1 | 0.255 |
TNK2 |
0.696 | -0.116 | 3 | 0.675 |
JAK3 |
0.695 | -0.162 | 1 | 0.310 |
ABL1 |
0.695 | -0.130 | -1 | 0.744 |
DDR1 |
0.694 | -0.179 | 4 | 0.755 |
JAK1 |
0.694 | -0.115 | 1 | 0.274 |
TXK |
0.693 | -0.109 | 1 | 0.278 |
YES1 |
0.692 | -0.144 | -1 | 0.794 |
LCK |
0.691 | -0.117 | -1 | 0.781 |
FGR |
0.690 | -0.205 | 1 | 0.299 |
FGFR2 |
0.690 | -0.116 | 3 | 0.713 |
BLK |
0.688 | -0.109 | -1 | 0.785 |
HCK |
0.688 | -0.176 | -1 | 0.774 |
KDR |
0.688 | -0.144 | 3 | 0.689 |
FGFR1 |
0.688 | -0.109 | 3 | 0.685 |
TEK |
0.687 | -0.080 | 3 | 0.660 |
KIT |
0.687 | -0.172 | 3 | 0.724 |
INSRR |
0.687 | -0.196 | 3 | 0.669 |
EPHA4 |
0.686 | -0.134 | 2 | 0.727 |
WEE1_TYR |
0.686 | -0.098 | -1 | 0.720 |
FLT3 |
0.686 | -0.206 | 3 | 0.744 |
FER |
0.686 | -0.232 | 1 | 0.314 |
ITK |
0.685 | -0.176 | -1 | 0.743 |
SRMS |
0.683 | -0.214 | 1 | 0.282 |
MET |
0.683 | -0.157 | 3 | 0.708 |
PDGFRB |
0.682 | -0.262 | 3 | 0.734 |
AXL |
0.681 | -0.214 | 3 | 0.691 |
EPHB1 |
0.680 | -0.224 | 1 | 0.277 |
MERTK |
0.680 | -0.191 | 3 | 0.700 |
FYN |
0.680 | -0.109 | -1 | 0.767 |
EPHB3 |
0.680 | -0.210 | -1 | 0.753 |
PDGFRA |
0.679 | -0.254 | 3 | 0.734 |
EPHB2 |
0.679 | -0.198 | -1 | 0.748 |
BMX |
0.679 | -0.146 | -1 | 0.678 |
DDR2 |
0.679 | -0.098 | 3 | 0.650 |
FGFR3 |
0.677 | -0.133 | 3 | 0.680 |
FRK |
0.675 | -0.179 | -1 | 0.778 |
ALK |
0.675 | -0.212 | 3 | 0.641 |
PTK6 |
0.674 | -0.224 | -1 | 0.667 |
BTK |
0.673 | -0.258 | -1 | 0.699 |
FLT1 |
0.673 | -0.192 | -1 | 0.782 |
TEC |
0.673 | -0.202 | -1 | 0.673 |
ERBB2 |
0.673 | -0.208 | 1 | 0.278 |
CK1G3 |
0.672 | -0.103 | -3 | 0.269 |
EPHA7 |
0.672 | -0.183 | 2 | 0.731 |
MATK |
0.672 | -0.133 | -1 | 0.692 |
LTK |
0.672 | -0.220 | 3 | 0.667 |
INSR |
0.671 | -0.209 | 3 | 0.651 |
EGFR |
0.671 | -0.135 | 1 | 0.231 |
FLT4 |
0.671 | -0.214 | 3 | 0.682 |
YANK2 |
0.670 | -0.111 | 2 | 0.384 |
PTK2B |
0.670 | -0.151 | -1 | 0.715 |
EPHA1 |
0.670 | -0.216 | 3 | 0.686 |
NTRK1 |
0.670 | -0.270 | -1 | 0.761 |
EPHA3 |
0.669 | -0.201 | 2 | 0.703 |
LYN |
0.669 | -0.187 | 3 | 0.658 |
NTRK3 |
0.668 | -0.190 | -1 | 0.716 |
SRC |
0.668 | -0.157 | -1 | 0.752 |
CSK |
0.668 | -0.168 | 2 | 0.737 |
PTK2 |
0.666 | -0.088 | -1 | 0.756 |
NTRK2 |
0.665 | -0.279 | 3 | 0.670 |
FGFR4 |
0.664 | -0.145 | -1 | 0.709 |
SYK |
0.664 | -0.110 | -1 | 0.736 |
EPHA8 |
0.663 | -0.169 | -1 | 0.745 |
MUSK |
0.661 | -0.172 | 1 | 0.225 |
EPHA5 |
0.660 | -0.208 | 2 | 0.710 |
ZAP70 |
0.658 | -0.071 | -1 | 0.684 |
ERBB4 |
0.657 | -0.126 | 1 | 0.238 |
EPHA2 |
0.654 | -0.178 | -1 | 0.710 |
IGF1R |
0.653 | -0.196 | 3 | 0.586 |
CK1G2 |
0.652 | -0.106 | -3 | 0.355 |
FES |
0.640 | -0.192 | -1 | 0.646 |