Motif 145 (n=194)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A7E2V4 | ZSWIM8 | S1040 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A7KAX9 | ARHGAP32 | S1220 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7MCY6 | TBKBP1 | S335 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| O14497 | ARID1A | S1338 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14654 | IRS4 | Y743 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15047 | SETD1A | S450 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15392 | BIRC5 | S20 | psp | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}. |
| O43593 | HR | S416 | ochoa | Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}. |
| O60307 | MAST3 | S1183 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O75362 | ZNF217 | S407 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75410 | TACC1 | S54 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75427 | LRCH4 | S267 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75449 | KATNA1 | S93 | ochoa | Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| O94762 | RECQL5 | S858 | ochoa | ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5) | DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052, PubMed:28100692). Probably unwinds DNA in a 3'-5' direction (Probable) (PubMed:28100692). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Also associates with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA (PubMed:28100692). {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:27502483, ECO:0000269|PubMed:28100692, ECO:0000269|PubMed:28575661, ECO:0000305|PubMed:28100692}. |
| O95251 | KAT7 | S124 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95359 | TACC2 | S1946 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95835 | LATS1 | S204 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| O96013 | PAK4 | S244 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P00533 | EGFR | S1104 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02724 | GYPA | S121 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P06733 | ENO1 | S254 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07947 | YES1 | S26 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P10398 | ARAF | S172 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P15822 | HIVEP1 | S841 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18084 | ITGB5 | S762 | psp | Integrin beta-5 | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
| P20929 | NEB | S45 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P27816 | MAP4 | S715 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30291 | WEE1 | S136 | ochoa | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P35568 | IRS1 | S374 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35606 | COPB2 | S847 | ochoa | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| P42694 | HELZ | S1317 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P43364 | MAGEA11 | S199 | psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P43403 | ZAP70 | Y292 | ochoa|psp | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46013 | MKI67 | S2814 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48436 | SOX9 | S214 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P49790 | NUP153 | S619 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50238 | CRIP1 | S40 | ochoa | Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP) | Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. |
| P51003 | PAPOLA | S718 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51798 | CLCN7 | S61 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P52948 | NUP98 | S656 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P55011 | SLC12A2 | S957 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55196 | AFDN | S1126 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P60983 | GMFB | S83 | psp | Glia maturation factor beta (GMF-beta) | This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. |
| P68431 | H3C1 | S29 | ochoa | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P78344 | EIF4G2 | S500 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78559 | MAP1A | S1762 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P80723 | BASP1 | S205 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P84243 | H3-3A | S29 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q01484 | ANK2 | S1810 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01581 | HMGCS1 | S486 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q03164 | KMT2A | S504 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q0JRZ9 | FCHO2 | S474 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12789 | GTF3C1 | S1842 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q13428 | TCOF1 | S1102 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13443 | ADAM9 | S752 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q13480 | GAB1 | S208 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13884 | SNTB1 | S205 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q14161 | GIT2 | S614 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14202 | ZMYM3 | S37 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14517 | FAT1 | S4243 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14676 | MDC1 | S981 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1153 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1194 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1235 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1276 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1317 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1399 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1440 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1481 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1522 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1563 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1604 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14694 | USP10 | S341 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14766 | LTBP1 | S539 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15772 | SPEG | S540 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15811 | ITSN1 | S735 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q16512 | PKN1 | S902 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q16695 | H3-4 | S29 | ochoa | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q2M3G4 | SHROOM1 | S35 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2TAL5 | SMTNL2 | S269 | ochoa | Smoothelin-like protein 2 | None |
| Q4ADV7 | RIC1 | S987 | ochoa | Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}. |
| Q52LW3 | ARHGAP29 | S1227 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53H80 | AKIRIN2 | S111 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q53LP3 | SOWAHC | S212 | ochoa | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | None |
| Q5M775 | SPECC1 | S120 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SQI0 | ATAT1 | S237 | psp | Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}. |
| Q5SYE7 | NHSL1 | S1458 | ochoa | NHS-like protein 1 | None |
| Q5T1M5 | FKBP15 | S1097 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T7B8 | KIF24 | S1117 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TDH0 | DDI2 | S97 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q5TEC6 | H3-7 | S29 | ochoa | Histone H3-7 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}. |
| Q5THJ4 | VPS13D | S1709 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1148 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUA4 | ZNF318 | S684 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q63HR2 | TNS2 | S811 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68CZ2 | TNS3 | S887 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68EM7 | ARHGAP17 | S561 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6P0Q8 | MAST2 | S1381 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6W2J9 | BCOR | S1113 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZRI6 | C15orf39 | S455 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRV2 | FAM83H | S514 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q71DI3 | H3C15 | S29 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L5D6 | GET4 | S308 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z2W4 | ZC3HAV1 | S221 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3K3 | POGZ | S416 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z591 | AKNA | S38 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z6J9 | TSEN54 | S235 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q86W50 | METTL16 | S416 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86WB0 | ZC3HC1 | S53 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86X27 | RALGPS2 | S315 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86X29 | LSR | Y323 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XL3 | ANKLE2 | S905 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IVF2 | AHNAK2 | S5542 | ochoa | Protein AHNAK2 | None |
| Q8IW93 | ARHGEF19 | S101 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IY63 | AMOTL1 | S892 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IY92 | SLX4 | S1333 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZJ1 | UNC5B | Y457 | ochoa | Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). {ECO:0000250|UniProtKB:O08722, ECO:0000250|UniProtKB:Q8K1S3, ECO:0000269|PubMed:12598906}. |
| Q8N1G0 | ZNF687 | S239 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N2Y8 | RUSC2 | S342 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N3V7 | SYNPO | S819 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N6F7 | GCSAM | S129 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8NCG7 | DAGLB | S570 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8NDV7 | TNRC6A | S1585 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NDX1 | PSD4 | S109 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8TDN6 | BRIX1 | S247 | ochoa | Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) | Required for biogenesis of the 60S ribosomal subunit. |
| Q8TF76 | HASPIN | S165 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUM4 | PDCD6IP | S729 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WV28 | BLNK | S229 | ochoa | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WWI1 | LMO7 | S1205 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WZ73 | RFFL | S30 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92570 | NR4A3 | S376 | psp | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
| Q92786 | PROX1 | S453 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q93052 | LPP | S126 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96AW1 | VOPP1 | S99 | ochoa | WW domain binding protein VOPP1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N) (Vesicular, overexpressed in cancer, prosurvival protein 1) | Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed (PubMed:15735698). May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor (PubMed:30285739). {ECO:0000269|PubMed:15735698, ECO:0000269|PubMed:30285739}. |
| Q96AY4 | TTC28 | S2293 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96CX2 | KCTD12 | S162 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96D05 | FAM241B | S28 | ochoa | Protein FAM241B | May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}. |
| Q96D71 | REPS1 | S145 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96FS4 | SIPA1 | S53 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96II8 | LRCH3 | S583 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96JY6 | PDLIM2 | S120 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96SN8 | CDK5RAP2 | S1663 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96ST3 | SIN3A | S23 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96T37 | RBM15 | S656 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96TA1 | NIBAN2 | S624 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99501 | GAS2L1 | S292 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99569 | PKP4 | S392 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99700 | ATXN2 | S758 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BUR4 | WRAP53 | S76 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BV36 | MLPH | S252 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXL5 | HEMGN | S187 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BZL4 | PPP1R12C | S602 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0C2 | TNKS1BP1 | S297 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1371 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H093 | NUAK2 | S416 | ochoa | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H0H5 | RACGAP1 | S214 | ochoa|psp | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H211 | CDT1 | S79 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H6K1 | ILRUN | S237 | ochoa | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9HBD1 | RC3H2 | S794 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9HCK8 | CHD8 | S284 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NR12 | PDLIM7 | S203 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRA8 | EIF4ENIF1 | S499 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S797 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NSY1 | BMP2K | S1141 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NUW8 | TDP1 | S563 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9NX70 | MED29 | S137 | ochoa | Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15555573}. |
| Q9NXC5 | MIOS | S766 | ochoa | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25263562, PubMed:25457612, PubMed:26586190, PubMed:27487210). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (PubMed:35831510). The GATOR2 complex is required for brain myelination (By similarity). {ECO:0000250|UniProtKB:Q8VE19, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| Q9NYB9 | ABI2 | Y213 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9P0V3 | SH3BP4 | S117 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P260 | RELCH | S439 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P266 | JCAD | S915 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D0 | IBTK | S1069 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UDY2 | TJP2 | S952 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UJF2 | RASAL2 | S758 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK76 | JPT1 | S115 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKS6 | PACSIN3 | S327 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9ULD5 | ZNF777 | S143 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9UM11 | FZR1 | S137 | ochoa | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. |
| Q9UN70 | PCDHGC3 | S766 | ochoa | Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Q9UQ35 | SRRM2 | S2123 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2412 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQR0 | SCML2 | S547 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y285 | FARSA | S184 | ochoa | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| Q9Y2J4 | AMOTL2 | S727 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2W1 | THRAP3 | S234 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4F5 | CEP170B | S868 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| P27824 | CANX | S362 | Sugiyama | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| O15067 | PFAS | S1053 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q9H4A3 | WNK1 | S2100 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| O75122 | CLASP2 | S974 | Sugiyama | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| Q9HBL0 | TNS1 | S858 | Sugiyama | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q15569 | TESK1 | S353 | Sugiyama | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q86UE8 | TLK2 | S85 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q8IWW6 | ARHGAP12 | S223 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.454507e-08 | 7.263 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 8.782446e-06 | 5.056 |
| R-HSA-2028269 | Signaling by Hippo | 1.820544e-04 | 3.740 |
| R-HSA-211000 | Gene Silencing by RNA | 1.397584e-04 | 3.855 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.935080e-04 | 3.532 |
| R-HSA-68875 | Mitotic Prophase | 3.087616e-04 | 3.510 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.598785e-04 | 3.181 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.140640e-03 | 2.943 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.260591e-03 | 2.899 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.260591e-03 | 2.899 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.526467e-03 | 2.816 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.526467e-03 | 2.816 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.673025e-03 | 2.776 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.994948e-03 | 2.700 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.762674e-03 | 2.559 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.982188e-03 | 2.525 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.213330e-03 | 2.493 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.213330e-03 | 2.493 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.357348e-03 | 2.628 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.673025e-03 | 2.776 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.829082e-03 | 2.738 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.954154e-03 | 2.709 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.982188e-03 | 2.525 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.982188e-03 | 2.525 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.213330e-03 | 2.493 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.929481e-03 | 2.533 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.554494e-03 | 2.593 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.762674e-03 | 2.559 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.996435e-03 | 2.523 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.996435e-03 | 2.523 |
| R-HSA-418990 | Adherens junctions interactions | 3.183692e-03 | 2.497 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.101394e-03 | 2.508 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.272857e-03 | 2.485 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.553589e-03 | 2.342 |
| R-HSA-1640170 | Cell Cycle | 4.594175e-03 | 2.338 |
| R-HSA-446728 | Cell junction organization | 4.431658e-03 | 2.353 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.860518e-03 | 2.313 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.860518e-03 | 2.313 |
| R-HSA-68886 | M Phase | 4.888617e-03 | 2.311 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.136074e-03 | 2.289 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.515425e-03 | 2.258 |
| R-HSA-9609690 | HCMV Early Events | 5.836378e-03 | 2.234 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.836378e-03 | 2.234 |
| R-HSA-912446 | Meiotic recombination | 6.604304e-03 | 2.180 |
| R-HSA-9610379 | HCMV Late Events | 6.665726e-03 | 2.176 |
| R-HSA-1266695 | Interleukin-7 signaling | 7.068660e-03 | 2.151 |
| R-HSA-421270 | Cell-cell junction organization | 7.255250e-03 | 2.139 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 8.374778e-03 | 2.077 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.730124e-03 | 2.112 |
| R-HSA-5334118 | DNA methylation | 9.813520e-03 | 2.008 |
| R-HSA-191859 | snRNP Assembly | 1.017906e-02 | 1.992 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.017906e-02 | 1.992 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 9.735332e-03 | 2.012 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.189754e-03 | 2.037 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 9.676187e-03 | 2.014 |
| R-HSA-1500931 | Cell-Cell communication | 9.870290e-03 | 2.006 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.069857e-02 | 1.971 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.069857e-02 | 1.971 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.123491e-02 | 1.949 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.178829e-02 | 1.929 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.417569e-02 | 1.848 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.309852e-02 | 1.883 |
| R-HSA-70171 | Glycolysis | 1.308404e-02 | 1.883 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.494853e-02 | 1.825 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.693872e-02 | 1.771 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.713613e-02 | 1.766 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.713613e-02 | 1.766 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.798669e-02 | 1.745 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.826550e-02 | 1.738 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.904825e-02 | 1.720 |
| R-HSA-9609646 | HCMV Infection | 2.048301e-02 | 1.689 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.132797e-02 | 1.671 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.134300e-02 | 1.671 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.253271e-02 | 1.647 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.253271e-02 | 1.647 |
| R-HSA-70326 | Glucose metabolism | 2.464795e-02 | 1.608 |
| R-HSA-9710421 | Defective pyroptosis | 2.631474e-02 | 1.580 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.667564e-02 | 1.574 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.667564e-02 | 1.574 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.764627e-02 | 1.558 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.107557e-02 | 1.508 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.107557e-02 | 1.508 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 2.854276e-02 | 1.545 |
| R-HSA-1500620 | Meiosis | 2.957015e-02 | 1.529 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.107557e-02 | 1.508 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.858548e-02 | 1.544 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.854276e-02 | 1.545 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.332482e-02 | 1.477 |
| R-HSA-180292 | GAB1 signalosome | 3.369375e-02 | 1.472 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.369375e-02 | 1.472 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.529451e-02 | 1.452 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.639484e-02 | 1.439 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.657786e-02 | 1.437 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.702268e-02 | 1.432 |
| R-HSA-2559583 | Cellular Senescence | 3.913200e-02 | 1.407 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.956175e-02 | 1.403 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.120711e-02 | 1.385 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.155723e-02 | 1.381 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.203609e-02 | 1.376 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.203609e-02 | 1.376 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 4.203609e-02 | 1.376 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.347983e-02 | 1.272 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.171299e-02 | 1.286 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.366716e-02 | 1.270 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.328941e-02 | 1.364 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.347983e-02 | 1.272 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 4.798047e-02 | 1.319 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.347983e-02 | 1.272 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.061119e-02 | 1.296 |
| R-HSA-429947 | Deadenylation of mRNA | 5.420988e-02 | 1.266 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.557902e-02 | 1.255 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.631267e-02 | 1.249 |
| R-HSA-3214842 | HDMs demethylate histones | 5.742600e-02 | 1.241 |
| R-HSA-8865999 | MET activates PTPN11 | 6.022038e-02 | 1.220 |
| R-HSA-8875513 | MET interacts with TNS proteins | 6.022038e-02 | 1.220 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 6.022038e-02 | 1.220 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 6.070690e-02 | 1.217 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.150666e-02 | 1.211 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.350005e-02 | 1.197 |
| R-HSA-69306 | DNA Replication | 6.350005e-02 | 1.197 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.354560e-02 | 1.197 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 7.182424e-02 | 1.144 |
| R-HSA-74713 | IRS activation | 8.328552e-02 | 1.079 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 7.091779e-02 | 1.149 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.419967e-02 | 1.130 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 7.091779e-02 | 1.149 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.604421e-02 | 1.180 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 8.328552e-02 | 1.079 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.475552e-02 | 1.189 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 7.443751e-02 | 1.128 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.642012e-02 | 1.117 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 7.801205e-02 | 1.108 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 8.163955e-02 | 1.088 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.165850e-02 | 1.145 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.325472e-02 | 1.080 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 8.531817e-02 | 1.069 |
| R-HSA-74160 | Gene expression (Transcription) | 7.608150e-02 | 1.119 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.860529e-02 | 1.164 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.003644e-02 | 1.155 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 8.531817e-02 | 1.069 |
| R-HSA-212436 | Generic Transcription Pathway | 8.174533e-02 | 1.088 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 8.328552e-02 | 1.079 |
| R-HSA-162587 | HIV Life Cycle | 6.860529e-02 | 1.164 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 9.460599e-02 | 1.024 |
| R-HSA-176417 | Phosphorylation of Emi1 | 9.460599e-02 | 1.024 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 9.460599e-02 | 1.024 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.057873e-01 | 0.976 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.168313e-01 | 0.932 |
| R-HSA-112412 | SOS-mediated signalling | 1.168313e-01 | 0.932 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.168313e-01 | 0.932 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.277395e-01 | 0.894 |
| R-HSA-8875656 | MET receptor recycling | 1.277395e-01 | 0.894 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.277395e-01 | 0.894 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.277395e-01 | 0.894 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.277395e-01 | 0.894 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.277395e-01 | 0.894 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.130209e-01 | 0.947 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.130209e-01 | 0.947 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.163788e-01 | 0.934 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.867647e-02 | 1.006 |
| R-HSA-4839726 | Chromatin organization | 1.203829e-01 | 0.919 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.057873e-01 | 0.976 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.168313e-01 | 0.932 |
| R-HSA-8875878 | MET promotes cell motility | 1.083651e-01 | 0.965 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.168313e-01 | 0.932 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 9.664291e-02 | 1.015 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.122013e-02 | 1.040 |
| R-HSA-8964046 | VLDL clearance | 1.168313e-01 | 0.932 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.312629e-01 | 0.882 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.168313e-01 | 0.932 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.168313e-01 | 0.932 |
| R-HSA-1566948 | Elastic fibre formation | 1.083651e-01 | 0.965 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.204407e-01 | 0.919 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 8.904610e-02 | 1.050 |
| R-HSA-8853659 | RET signaling | 1.005084e-01 | 0.998 |
| R-HSA-8939211 | ESR-mediated signaling | 1.028377e-01 | 0.988 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 9.460599e-02 | 1.024 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 8.795203e-02 | 1.056 |
| R-HSA-1474165 | Reproduction | 1.099804e-01 | 0.959 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.275876e-02 | 1.033 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.044163e-01 | 0.981 |
| R-HSA-201556 | Signaling by ALK | 1.123531e-01 | 0.949 |
| R-HSA-73864 | RNA Polymerase I Transcription | 9.275876e-02 | 1.033 |
| R-HSA-422475 | Axon guidance | 9.681930e-02 | 1.014 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.286672e-01 | 0.891 |
| R-HSA-168255 | Influenza Infection | 1.021886e-01 | 0.991 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.277395e-01 | 0.894 |
| R-HSA-162909 | Host Interactions of HIV factors | 9.445094e-02 | 1.025 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.186160e-01 | 0.926 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.005084e-01 | 0.998 |
| R-HSA-195721 | Signaling by WNT | 1.034037e-01 | 0.985 |
| R-HSA-72306 | tRNA processing | 8.820439e-02 | 1.055 |
| R-HSA-3371556 | Cellular response to heat stress | 8.891592e-02 | 1.051 |
| R-HSA-977225 | Amyloid fiber formation | 1.001676e-01 | 0.999 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.210191e-01 | 0.917 |
| R-HSA-9675108 | Nervous system development | 1.327227e-01 | 0.877 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.328288e-01 | 0.877 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.328784e-01 | 0.877 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.491554e-01 | 0.826 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.596664e-01 | 0.797 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.700481e-01 | 0.769 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.803022e-01 | 0.744 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.004337e-01 | 0.698 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.103143e-01 | 0.677 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.103143e-01 | 0.677 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.103143e-01 | 0.677 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.200733e-01 | 0.657 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.579239e-01 | 0.589 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.670974e-01 | 0.573 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.670974e-01 | 0.573 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.670974e-01 | 0.573 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.298783e-01 | 0.639 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.481468e-01 | 0.605 |
| R-HSA-177929 | Signaling by EGFR | 1.892223e-01 | 0.723 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.527487e-01 | 0.597 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.527487e-01 | 0.597 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.527487e-01 | 0.597 |
| R-HSA-198203 | PI3K/AKT activation | 1.491554e-01 | 0.826 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.847649e-01 | 0.733 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.297123e-01 | 0.639 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.026781e-01 | 0.693 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.701169e-01 | 0.769 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.759287e-01 | 0.755 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.759287e-01 | 0.755 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.491554e-01 | 0.826 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.803022e-01 | 0.744 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.004337e-01 | 0.698 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.392328e-01 | 0.621 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.390036e-01 | 0.622 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.004337e-01 | 0.698 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.103143e-01 | 0.677 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.297123e-01 | 0.639 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.803022e-01 | 0.744 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.608440e-01 | 0.794 |
| R-HSA-3214847 | HATs acetylate histones | 1.578764e-01 | 0.802 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.491554e-01 | 0.826 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.297123e-01 | 0.639 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.404489e-01 | 0.852 |
| R-HSA-112399 | IRS-mediated signalling | 1.936943e-01 | 0.713 |
| R-HSA-74749 | Signal attenuation | 1.491554e-01 | 0.826 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.670974e-01 | 0.573 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.758984e-01 | 0.755 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.904302e-01 | 0.720 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.670974e-01 | 0.573 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.026781e-01 | 0.693 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.253245e-01 | 0.647 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.370207e-01 | 0.863 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.004337e-01 | 0.698 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.103143e-01 | 0.677 |
| R-HSA-157579 | Telomere Maintenance | 1.519937e-01 | 0.818 |
| R-HSA-426048 | Arachidonate production from DAG | 1.491554e-01 | 0.826 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.579239e-01 | 0.589 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.387586e-01 | 0.858 |
| R-HSA-73886 | Chromosome Maintenance | 2.362804e-01 | 0.627 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.362804e-01 | 0.627 |
| R-HSA-9842663 | Signaling by LTK | 1.803022e-01 | 0.744 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.664619e-01 | 0.574 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.428458e-01 | 0.615 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.385137e-01 | 0.859 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.491554e-01 | 0.826 |
| R-HSA-428540 | Activation of RAC1 | 1.700481e-01 | 0.769 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.618814e-01 | 0.582 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.412417e-01 | 0.850 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.803022e-01 | 0.744 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.803022e-01 | 0.744 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.803022e-01 | 0.744 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.004337e-01 | 0.698 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.913893e-01 | 0.718 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.392328e-01 | 0.621 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.297123e-01 | 0.639 |
| R-HSA-109704 | PI3K Cascade | 1.627357e-01 | 0.789 |
| R-HSA-69481 | G2/M Checkpoints | 2.593833e-01 | 0.586 |
| R-HSA-1266738 | Developmental Biology | 2.497112e-01 | 0.603 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.491554e-01 | 0.826 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.491554e-01 | 0.826 |
| R-HSA-210990 | PECAM1 interactions | 1.596664e-01 | 0.797 |
| R-HSA-392517 | Rap1 signalling | 2.579239e-01 | 0.589 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.892223e-01 | 0.723 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.697589e-01 | 0.770 |
| R-HSA-162582 | Signal Transduction | 1.547391e-01 | 0.810 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.344559e-01 | 0.871 |
| R-HSA-9683686 | Maturation of spike protein | 1.491554e-01 | 0.826 |
| R-HSA-157118 | Signaling by NOTCH | 2.234744e-01 | 0.651 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.579213e-01 | 0.802 |
| R-HSA-2586552 | Signaling by Leptin | 1.491554e-01 | 0.826 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.618814e-01 | 0.582 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.103143e-01 | 0.677 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.392328e-01 | 0.621 |
| R-HSA-69206 | G1/S Transition | 2.527487e-01 | 0.597 |
| R-HSA-445144 | Signal transduction by L1 | 2.670974e-01 | 0.573 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.659188e-01 | 0.780 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.071784e-01 | 0.684 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.803022e-01 | 0.744 |
| R-HSA-1989781 | PPARA activates gene expression | 1.697589e-01 | 0.770 |
| R-HSA-5693538 | Homology Directed Repair | 2.264942e-01 | 0.645 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.486361e-01 | 0.604 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.664619e-01 | 0.574 |
| R-HSA-168268 | Virus Assembly and Release | 2.200733e-01 | 0.657 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.207776e-01 | 0.656 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.264942e-01 | 0.645 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.370207e-01 | 0.863 |
| R-HSA-162906 | HIV Infection | 1.950013e-01 | 0.710 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.396652e-01 | 0.855 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.589389e-01 | 0.587 |
| R-HSA-5619102 | SLC transporter disorders | 1.993578e-01 | 0.700 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.693780e-01 | 0.570 |
| R-HSA-68877 | Mitotic Prometaphase | 2.706698e-01 | 0.568 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.756221e-01 | 0.560 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.756221e-01 | 0.560 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.851072e-01 | 0.545 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.851072e-01 | 0.545 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.851072e-01 | 0.545 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.851072e-01 | 0.545 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.893500e-01 | 0.539 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.893500e-01 | 0.539 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 2.939201e-01 | 0.532 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.939201e-01 | 0.532 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.939463e-01 | 0.532 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.939463e-01 | 0.532 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.939463e-01 | 0.532 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.939463e-01 | 0.532 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.939463e-01 | 0.532 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.939463e-01 | 0.532 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.939463e-01 | 0.532 |
| R-HSA-8964038 | LDL clearance | 2.939463e-01 | 0.532 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.981883e-01 | 0.526 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.984863e-01 | 0.525 |
| R-HSA-6806834 | Signaling by MET | 2.984863e-01 | 0.525 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.026766e-01 | 0.519 |
| R-HSA-3000170 | Syndecan interactions | 3.026766e-01 | 0.519 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.026766e-01 | 0.519 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.026766e-01 | 0.519 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.030478e-01 | 0.518 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.112996e-01 | 0.507 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.112996e-01 | 0.507 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.112996e-01 | 0.507 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.112996e-01 | 0.507 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.198164e-01 | 0.495 |
| R-HSA-9839394 | TGFBR3 expression | 3.198164e-01 | 0.495 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.198164e-01 | 0.495 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.198164e-01 | 0.495 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.212371e-01 | 0.493 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.282284e-01 | 0.484 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.282284e-01 | 0.484 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.282284e-01 | 0.484 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.282284e-01 | 0.484 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.282284e-01 | 0.484 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.333557e-01 | 0.477 |
| R-HSA-73894 | DNA Repair | 3.343788e-01 | 0.476 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.365369e-01 | 0.473 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.365369e-01 | 0.473 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.365369e-01 | 0.473 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.365369e-01 | 0.473 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.365369e-01 | 0.473 |
| R-HSA-68882 | Mitotic Anaphase | 3.372243e-01 | 0.472 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.400252e-01 | 0.468 |
| R-HSA-69242 | S Phase | 3.401106e-01 | 0.468 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.409430e-01 | 0.467 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.447432e-01 | 0.463 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.447432e-01 | 0.463 |
| R-HSA-1280218 | Adaptive Immune System | 3.480930e-01 | 0.458 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.482921e-01 | 0.458 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.527683e-01 | 0.453 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.528484e-01 | 0.452 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.528484e-01 | 0.452 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.528484e-01 | 0.452 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.528484e-01 | 0.452 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.608539e-01 | 0.443 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.608539e-01 | 0.443 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.608539e-01 | 0.443 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.608539e-01 | 0.443 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.608539e-01 | 0.443 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.608539e-01 | 0.443 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.616885e-01 | 0.442 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.616885e-01 | 0.442 |
| R-HSA-182971 | EGFR downregulation | 3.687608e-01 | 0.433 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.687608e-01 | 0.433 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.687608e-01 | 0.433 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.687608e-01 | 0.433 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.708589e-01 | 0.431 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.765704e-01 | 0.424 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.765704e-01 | 0.424 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.765704e-01 | 0.424 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.804844e-01 | 0.420 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.837822e-01 | 0.416 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.837822e-01 | 0.416 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.837822e-01 | 0.416 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.842839e-01 | 0.415 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.842839e-01 | 0.415 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.842839e-01 | 0.415 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.842839e-01 | 0.415 |
| R-HSA-913531 | Interferon Signaling | 3.871751e-01 | 0.412 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.881624e-01 | 0.411 |
| R-HSA-390522 | Striated Muscle Contraction | 3.919024e-01 | 0.407 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.919024e-01 | 0.407 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.919024e-01 | 0.407 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.919024e-01 | 0.407 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.938396e-01 | 0.405 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.968817e-01 | 0.401 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.994271e-01 | 0.399 |
| R-HSA-5673000 | RAF activation | 3.994271e-01 | 0.399 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.994271e-01 | 0.399 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.994271e-01 | 0.399 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.994271e-01 | 0.399 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.068592e-01 | 0.391 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.068592e-01 | 0.391 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.068592e-01 | 0.391 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.068592e-01 | 0.391 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.141997e-01 | 0.383 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.141997e-01 | 0.383 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.141997e-01 | 0.383 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.141997e-01 | 0.383 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.141997e-01 | 0.383 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.214498e-01 | 0.375 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.214498e-01 | 0.375 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.238080e-01 | 0.373 |
| R-HSA-73927 | Depurination | 4.286107e-01 | 0.368 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.286107e-01 | 0.368 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.286107e-01 | 0.368 |
| R-HSA-69239 | Synthesis of DNA | 4.353770e-01 | 0.361 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.356833e-01 | 0.361 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.356833e-01 | 0.361 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.395739e-01 | 0.357 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.395739e-01 | 0.357 |
| R-HSA-202433 | Generation of second messenger molecules | 4.426689e-01 | 0.354 |
| R-HSA-9694548 | Maturation of spike protein | 4.495684e-01 | 0.347 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.495684e-01 | 0.347 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.495684e-01 | 0.347 |
| R-HSA-199991 | Membrane Trafficking | 4.514016e-01 | 0.345 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.563829e-01 | 0.341 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.563829e-01 | 0.341 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.563829e-01 | 0.341 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.563829e-01 | 0.341 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.563829e-01 | 0.341 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.563829e-01 | 0.341 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.563829e-01 | 0.341 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.631134e-01 | 0.334 |
| R-HSA-73928 | Depyrimidination | 4.631134e-01 | 0.334 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.631134e-01 | 0.334 |
| R-HSA-165159 | MTOR signalling | 4.631134e-01 | 0.334 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.675551e-01 | 0.330 |
| R-HSA-69275 | G2/M Transition | 4.688474e-01 | 0.329 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.697611e-01 | 0.328 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.697611e-01 | 0.328 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.697611e-01 | 0.328 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.751863e-01 | 0.323 |
| R-HSA-373752 | Netrin-1 signaling | 4.763268e-01 | 0.322 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.801101e-01 | 0.319 |
| R-HSA-373760 | L1CAM interactions | 4.805745e-01 | 0.318 |
| R-HSA-5617833 | Cilium Assembly | 4.814906e-01 | 0.317 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.828116e-01 | 0.316 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.828116e-01 | 0.316 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.848431e-01 | 0.314 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.892165e-01 | 0.310 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.892165e-01 | 0.310 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.892165e-01 | 0.310 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.892165e-01 | 0.310 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.892165e-01 | 0.310 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.892165e-01 | 0.310 |
| R-HSA-75153 | Apoptotic execution phase | 4.892165e-01 | 0.310 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.925148e-01 | 0.308 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.949053e-01 | 0.305 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.955425e-01 | 0.305 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.955425e-01 | 0.305 |
| R-HSA-70263 | Gluconeogenesis | 5.017906e-01 | 0.299 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.017906e-01 | 0.299 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.079616e-01 | 0.294 |
| R-HSA-73893 | DNA Damage Bypass | 5.079616e-01 | 0.294 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.081648e-01 | 0.294 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.124610e-01 | 0.290 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.140566e-01 | 0.289 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 5.140566e-01 | 0.289 |
| R-HSA-72187 | mRNA 3'-end processing | 5.260221e-01 | 0.279 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.260221e-01 | 0.279 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.260221e-01 | 0.279 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.260221e-01 | 0.279 |
| R-HSA-2262752 | Cellular responses to stress | 5.297031e-01 | 0.276 |
| R-HSA-5357801 | Programmed Cell Death | 5.305716e-01 | 0.275 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.318536e-01 | 0.274 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.318944e-01 | 0.274 |
| R-HSA-1221632 | Meiotic synapsis | 5.318944e-01 | 0.274 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.318944e-01 | 0.274 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.318944e-01 | 0.274 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.358644e-01 | 0.271 |
| R-HSA-72649 | Translation initiation complex formation | 5.376944e-01 | 0.269 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.376944e-01 | 0.269 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.376944e-01 | 0.269 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.434228e-01 | 0.265 |
| R-HSA-9843745 | Adipogenesis | 5.458936e-01 | 0.263 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.490806e-01 | 0.260 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.490806e-01 | 0.260 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.495544e-01 | 0.260 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.510137e-01 | 0.259 |
| R-HSA-449147 | Signaling by Interleukins | 5.532173e-01 | 0.257 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.535136e-01 | 0.257 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.546687e-01 | 0.256 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.601878e-01 | 0.252 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.601878e-01 | 0.252 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.648702e-01 | 0.248 |
| R-HSA-180786 | Extension of Telomeres | 5.656389e-01 | 0.247 |
| R-HSA-983189 | Kinesins | 5.710227e-01 | 0.243 |
| R-HSA-379724 | tRNA Aminoacylation | 5.710227e-01 | 0.243 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.710844e-01 | 0.243 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.763402e-01 | 0.239 |
| R-HSA-1442490 | Collagen degradation | 5.763402e-01 | 0.239 |
| R-HSA-8951664 | Neddylation | 5.769739e-01 | 0.239 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.815680e-01 | 0.235 |
| R-HSA-9664407 | Parasite infection | 5.815680e-01 | 0.235 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.815680e-01 | 0.235 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.815921e-01 | 0.235 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.815921e-01 | 0.235 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.867791e-01 | 0.232 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.867791e-01 | 0.232 |
| R-HSA-8848021 | Signaling by PTK6 | 5.867791e-01 | 0.232 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.867791e-01 | 0.232 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.019596e-01 | 0.220 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.068954e-01 | 0.217 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.086023e-01 | 0.216 |
| R-HSA-5218859 | Regulated Necrosis | 6.117703e-01 | 0.213 |
| R-HSA-166520 | Signaling by NTRKs | 6.118872e-01 | 0.213 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.213403e-01 | 0.207 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.248174e-01 | 0.204 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.248174e-01 | 0.204 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.260370e-01 | 0.203 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.260370e-01 | 0.203 |
| R-HSA-3000178 | ECM proteoglycans | 6.260370e-01 | 0.203 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.260370e-01 | 0.203 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.260370e-01 | 0.203 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.306756e-01 | 0.200 |
| R-HSA-73887 | Death Receptor Signaling | 6.311571e-01 | 0.200 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.352571e-01 | 0.197 |
| R-HSA-4086398 | Ca2+ pathway | 6.352571e-01 | 0.197 |
| R-HSA-1474244 | Extracellular matrix organization | 6.360828e-01 | 0.196 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.397819e-01 | 0.194 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.397819e-01 | 0.194 |
| R-HSA-9711097 | Cellular response to starvation | 6.435868e-01 | 0.191 |
| R-HSA-380287 | Centrosome maturation | 6.442509e-01 | 0.191 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.530241e-01 | 0.185 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.530241e-01 | 0.185 |
| R-HSA-109581 | Apoptosis | 6.556855e-01 | 0.183 |
| R-HSA-216083 | Integrin cell surface interactions | 6.573296e-01 | 0.182 |
| R-HSA-191273 | Cholesterol biosynthesis | 6.573296e-01 | 0.182 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.599131e-01 | 0.181 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.657819e-01 | 0.177 |
| R-HSA-109582 | Hemostasis | 6.727614e-01 | 0.172 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.780728e-01 | 0.169 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.820690e-01 | 0.166 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.860158e-01 | 0.164 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.899139e-01 | 0.161 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.927560e-01 | 0.159 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.958137e-01 | 0.158 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.975661e-01 | 0.156 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.975661e-01 | 0.156 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.013215e-01 | 0.154 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.059618e-01 | 0.151 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.069369e-01 | 0.151 |
| R-HSA-73884 | Base Excision Repair | 7.086936e-01 | 0.150 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.158847e-01 | 0.145 |
| R-HSA-391251 | Protein folding | 7.194137e-01 | 0.143 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.194137e-01 | 0.143 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.194137e-01 | 0.143 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.228991e-01 | 0.141 |
| R-HSA-2029481 | FCGR activation | 7.228991e-01 | 0.141 |
| R-HSA-9679506 | SARS-CoV Infections | 7.233098e-01 | 0.141 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.258100e-01 | 0.139 |
| R-HSA-983712 | Ion channel transport | 7.313929e-01 | 0.136 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.386091e-01 | 0.132 |
| R-HSA-8953854 | Metabolism of RNA | 7.406837e-01 | 0.130 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.429251e-01 | 0.129 |
| R-HSA-190236 | Signaling by FGFR | 7.429251e-01 | 0.129 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.461198e-01 | 0.127 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.523912e-01 | 0.124 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.614832e-01 | 0.118 |
| R-HSA-9833110 | RSV-host interactions | 7.644753e-01 | 0.117 |
| R-HSA-9824446 | Viral Infection Pathways | 7.707389e-01 | 0.113 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.759725e-01 | 0.110 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.759725e-01 | 0.110 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.759725e-01 | 0.110 |
| R-HSA-202403 | TCR signaling | 7.815099e-01 | 0.107 |
| R-HSA-397014 | Muscle contraction | 7.846319e-01 | 0.105 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.869111e-01 | 0.104 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.869111e-01 | 0.104 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.947648e-01 | 0.100 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.958531e-01 | 0.099 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.973182e-01 | 0.098 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.998399e-01 | 0.097 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.023305e-01 | 0.096 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.023305e-01 | 0.096 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.047902e-01 | 0.094 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.143281e-01 | 0.089 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.211759e-01 | 0.086 |
| R-HSA-194138 | Signaling by VEGF | 8.256009e-01 | 0.083 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.277724e-01 | 0.082 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.300510e-01 | 0.081 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.320350e-01 | 0.080 |
| R-HSA-9909396 | Circadian clock | 8.422377e-01 | 0.075 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.422377e-01 | 0.075 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.518237e-01 | 0.070 |
| R-HSA-6807070 | PTEN Regulation | 8.572946e-01 | 0.067 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.608298e-01 | 0.065 |
| R-HSA-416476 | G alpha (q) signalling events | 8.692873e-01 | 0.061 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.772405e-01 | 0.057 |
| R-HSA-9609507 | Protein localization | 8.817773e-01 | 0.055 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.889707e-01 | 0.051 |
| R-HSA-9658195 | Leishmania infection | 8.895500e-01 | 0.051 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.895500e-01 | 0.051 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.917246e-01 | 0.050 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.091894e-01 | 0.041 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.091894e-01 | 0.041 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.091894e-01 | 0.041 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.114440e-01 | 0.040 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.147356e-01 | 0.039 |
| R-HSA-8957322 | Metabolism of steroids | 9.285498e-01 | 0.032 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.302698e-01 | 0.031 |
| R-HSA-72172 | mRNA Splicing | 9.392885e-01 | 0.027 |
| R-HSA-6805567 | Keratinization | 9.407988e-01 | 0.027 |
| R-HSA-5663205 | Infectious disease | 9.455743e-01 | 0.024 |
| R-HSA-15869 | Metabolism of nucleotides | 9.594442e-01 | 0.018 |
| R-HSA-597592 | Post-translational protein modification | 9.621203e-01 | 0.017 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.645701e-01 | 0.016 |
| R-HSA-5688426 | Deubiquitination | 9.680957e-01 | 0.014 |
| R-HSA-1643685 | Disease | 9.711628e-01 | 0.013 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.729305e-01 | 0.012 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.749088e-01 | 0.011 |
| R-HSA-168256 | Immune System | 9.753614e-01 | 0.011 |
| R-HSA-72766 | Translation | 9.766953e-01 | 0.010 |
| R-HSA-392499 | Metabolism of proteins | 9.863479e-01 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 9.900327e-01 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.948055e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.955393e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.987234e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.999742e-01 | 0.000 |
| R-HSA-168249 | Innate Immune System | 9.999995e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.894 | 0.474 | 1 | 0.895 |
COT |
0.883 | 0.221 | 2 | 0.823 |
CLK2 |
0.872 | 0.383 | -3 | 0.762 |
PIM3 |
0.872 | 0.190 | -3 | 0.841 |
SRPK1 |
0.872 | 0.265 | -3 | 0.762 |
NDR2 |
0.870 | 0.141 | -3 | 0.847 |
HIPK4 |
0.868 | 0.305 | 1 | 0.855 |
CDC7 |
0.866 | 0.111 | 1 | 0.837 |
KIS |
0.865 | 0.280 | 1 | 0.826 |
MTOR |
0.864 | 0.103 | 1 | 0.810 |
MOS |
0.864 | 0.130 | 1 | 0.860 |
PIM1 |
0.863 | 0.199 | -3 | 0.804 |
RSK2 |
0.863 | 0.175 | -3 | 0.789 |
CDKL1 |
0.862 | 0.181 | -3 | 0.807 |
NLK |
0.862 | 0.222 | 1 | 0.899 |
SKMLCK |
0.862 | 0.181 | -2 | 0.914 |
SRPK2 |
0.861 | 0.220 | -3 | 0.690 |
ICK |
0.861 | 0.275 | -3 | 0.843 |
PRKD2 |
0.861 | 0.182 | -3 | 0.799 |
CDKL5 |
0.861 | 0.212 | -3 | 0.805 |
AURC |
0.861 | 0.238 | -2 | 0.732 |
CLK4 |
0.861 | 0.294 | -3 | 0.780 |
ERK5 |
0.860 | 0.206 | 1 | 0.900 |
PRKD1 |
0.860 | 0.139 | -3 | 0.841 |
NDR1 |
0.860 | 0.118 | -3 | 0.844 |
DYRK2 |
0.860 | 0.305 | 1 | 0.822 |
CAMK1B |
0.860 | 0.099 | -3 | 0.859 |
PRPK |
0.859 | -0.055 | -1 | 0.873 |
CDK1 |
0.859 | 0.339 | 1 | 0.779 |
CLK1 |
0.859 | 0.305 | -3 | 0.764 |
GRK1 |
0.858 | 0.150 | -2 | 0.825 |
CHAK2 |
0.858 | 0.170 | -1 | 0.877 |
IKKB |
0.857 | -0.067 | -2 | 0.780 |
RAF1 |
0.857 | -0.037 | 1 | 0.810 |
HIPK2 |
0.856 | 0.347 | 1 | 0.754 |
CAMK2G |
0.855 | -0.022 | 2 | 0.774 |
P90RSK |
0.855 | 0.119 | -3 | 0.781 |
PKACG |
0.855 | 0.149 | -2 | 0.811 |
PRKX |
0.855 | 0.245 | -3 | 0.719 |
PKACB |
0.854 | 0.216 | -2 | 0.748 |
ATR |
0.854 | 0.025 | 1 | 0.816 |
WNK1 |
0.854 | 0.073 | -2 | 0.910 |
MST4 |
0.853 | 0.101 | 2 | 0.778 |
CDK8 |
0.853 | 0.242 | 1 | 0.805 |
CDK7 |
0.853 | 0.266 | 1 | 0.811 |
DSTYK |
0.853 | -0.045 | 2 | 0.814 |
CAMLCK |
0.853 | 0.119 | -2 | 0.905 |
P70S6KB |
0.853 | 0.120 | -3 | 0.808 |
RSK3 |
0.852 | 0.112 | -3 | 0.772 |
LATS2 |
0.852 | 0.048 | -5 | 0.737 |
PDHK4 |
0.851 | -0.237 | 1 | 0.835 |
RSK4 |
0.851 | 0.179 | -3 | 0.759 |
CDK5 |
0.851 | 0.295 | 1 | 0.823 |
CDK19 |
0.851 | 0.256 | 1 | 0.774 |
BMPR2 |
0.851 | -0.133 | -2 | 0.909 |
NIK |
0.851 | 0.063 | -3 | 0.872 |
HIPK1 |
0.851 | 0.324 | 1 | 0.833 |
JNK2 |
0.850 | 0.304 | 1 | 0.765 |
DAPK2 |
0.850 | 0.112 | -3 | 0.867 |
NEK6 |
0.850 | 0.005 | -2 | 0.886 |
SRPK3 |
0.850 | 0.166 | -3 | 0.727 |
MAPKAPK2 |
0.850 | 0.099 | -3 | 0.758 |
NUAK2 |
0.849 | 0.056 | -3 | 0.855 |
TBK1 |
0.849 | -0.124 | 1 | 0.704 |
AMPKA1 |
0.849 | 0.091 | -3 | 0.868 |
CDK3 |
0.849 | 0.342 | 1 | 0.725 |
PAK1 |
0.849 | 0.134 | -2 | 0.851 |
CDK18 |
0.849 | 0.293 | 1 | 0.752 |
DYRK4 |
0.849 | 0.303 | 1 | 0.770 |
PKN2 |
0.849 | 0.054 | -3 | 0.853 |
GRK5 |
0.849 | -0.055 | -3 | 0.830 |
PKN3 |
0.849 | 0.009 | -3 | 0.828 |
PKCD |
0.848 | 0.104 | 2 | 0.701 |
CAMK2B |
0.848 | 0.092 | 2 | 0.755 |
CAMK2D |
0.848 | 0.012 | -3 | 0.858 |
CAMK2A |
0.848 | 0.103 | 2 | 0.764 |
GCN2 |
0.848 | -0.219 | 2 | 0.725 |
MAPKAPK3 |
0.848 | 0.056 | -3 | 0.804 |
IKKA |
0.848 | -0.006 | -2 | 0.772 |
ULK2 |
0.847 | -0.155 | 2 | 0.718 |
CDK13 |
0.847 | 0.237 | 1 | 0.786 |
RIPK3 |
0.847 | -0.053 | 3 | 0.729 |
MNK2 |
0.846 | 0.145 | -2 | 0.854 |
MSK1 |
0.846 | 0.143 | -3 | 0.767 |
GRK7 |
0.846 | 0.154 | 1 | 0.763 |
IKKE |
0.846 | -0.149 | 1 | 0.697 |
JNK3 |
0.845 | 0.263 | 1 | 0.791 |
AMPKA2 |
0.845 | 0.090 | -3 | 0.842 |
FAM20C |
0.845 | 0.079 | 2 | 0.613 |
MSK2 |
0.845 | 0.079 | -3 | 0.763 |
LATS1 |
0.844 | 0.132 | -3 | 0.848 |
NEK7 |
0.844 | -0.129 | -3 | 0.831 |
GRK6 |
0.844 | -0.001 | 1 | 0.821 |
P38B |
0.844 | 0.298 | 1 | 0.788 |
HUNK |
0.844 | -0.085 | 2 | 0.773 |
TGFBR2 |
0.844 | -0.045 | -2 | 0.830 |
MARK4 |
0.844 | -0.027 | 4 | 0.774 |
P38A |
0.843 | 0.277 | 1 | 0.841 |
BMPR1B |
0.843 | 0.148 | 1 | 0.813 |
AURB |
0.843 | 0.161 | -2 | 0.732 |
DYRK1B |
0.843 | 0.289 | 1 | 0.793 |
PAK3 |
0.843 | 0.075 | -2 | 0.845 |
MNK1 |
0.842 | 0.144 | -2 | 0.862 |
CDK12 |
0.842 | 0.247 | 1 | 0.764 |
DYRK1A |
0.842 | 0.252 | 1 | 0.846 |
P38G |
0.842 | 0.272 | 1 | 0.706 |
DLK |
0.841 | -0.052 | 1 | 0.821 |
CDK2 |
0.841 | 0.243 | 1 | 0.829 |
PKCB |
0.840 | 0.072 | 2 | 0.637 |
PDHK1 |
0.840 | -0.292 | 1 | 0.811 |
CDK10 |
0.840 | 0.298 | 1 | 0.773 |
PRKD3 |
0.840 | 0.095 | -3 | 0.761 |
ERK1 |
0.840 | 0.261 | 1 | 0.776 |
MLK1 |
0.840 | -0.144 | 2 | 0.720 |
PKG2 |
0.840 | 0.138 | -2 | 0.745 |
MASTL |
0.840 | -0.202 | -2 | 0.852 |
PKCG |
0.839 | 0.065 | 2 | 0.649 |
CDK17 |
0.839 | 0.256 | 1 | 0.707 |
TSSK1 |
0.839 | 0.045 | -3 | 0.883 |
CDK9 |
0.839 | 0.208 | 1 | 0.790 |
AKT2 |
0.839 | 0.141 | -3 | 0.716 |
MAK |
0.839 | 0.363 | -2 | 0.844 |
NIM1 |
0.838 | -0.014 | 3 | 0.759 |
TSSK2 |
0.838 | 0.001 | -5 | 0.834 |
ALK4 |
0.838 | 0.036 | -2 | 0.856 |
DYRK3 |
0.838 | 0.262 | 1 | 0.828 |
PAK6 |
0.838 | 0.119 | -2 | 0.772 |
ULK1 |
0.838 | -0.186 | -3 | 0.777 |
TGFBR1 |
0.838 | 0.057 | -2 | 0.830 |
CAMK4 |
0.837 | -0.024 | -3 | 0.839 |
GRK4 |
0.837 | -0.105 | -2 | 0.853 |
MYLK4 |
0.837 | 0.091 | -2 | 0.835 |
HIPK3 |
0.837 | 0.254 | 1 | 0.828 |
PKCA |
0.837 | 0.063 | 2 | 0.632 |
SGK3 |
0.837 | 0.127 | -3 | 0.795 |
PIM2 |
0.837 | 0.136 | -3 | 0.767 |
MLK2 |
0.836 | -0.088 | 2 | 0.742 |
CDK14 |
0.836 | 0.264 | 1 | 0.783 |
RIPK1 |
0.836 | -0.133 | 1 | 0.784 |
PKCZ |
0.836 | 0.053 | 2 | 0.694 |
WNK3 |
0.835 | -0.223 | 1 | 0.781 |
PLK1 |
0.835 | -0.032 | -2 | 0.848 |
ATM |
0.835 | -0.034 | 1 | 0.747 |
NEK9 |
0.835 | -0.169 | 2 | 0.752 |
PAK2 |
0.834 | 0.047 | -2 | 0.838 |
PKACA |
0.834 | 0.160 | -2 | 0.694 |
BCKDK |
0.834 | -0.216 | -1 | 0.800 |
AURA |
0.834 | 0.105 | -2 | 0.706 |
PRP4 |
0.833 | 0.173 | -3 | 0.753 |
MLK3 |
0.833 | -0.045 | 2 | 0.648 |
IRE1 |
0.833 | -0.077 | 1 | 0.769 |
DCAMKL1 |
0.833 | 0.087 | -3 | 0.804 |
PKR |
0.833 | 0.003 | 1 | 0.812 |
MELK |
0.832 | 0.002 | -3 | 0.828 |
GSK3A |
0.832 | 0.177 | 4 | 0.545 |
P38D |
0.832 | 0.271 | 1 | 0.719 |
ANKRD3 |
0.832 | -0.188 | 1 | 0.829 |
PASK |
0.832 | 0.129 | -3 | 0.862 |
ERK2 |
0.831 | 0.202 | 1 | 0.806 |
QSK |
0.831 | 0.006 | 4 | 0.740 |
DNAPK |
0.831 | 0.029 | 1 | 0.672 |
CDK16 |
0.831 | 0.258 | 1 | 0.719 |
VRK2 |
0.830 | -0.105 | 1 | 0.868 |
MEK1 |
0.830 | -0.134 | 2 | 0.792 |
NUAK1 |
0.830 | -0.008 | -3 | 0.801 |
ALK2 |
0.830 | 0.031 | -2 | 0.840 |
TTBK2 |
0.829 | -0.193 | 2 | 0.655 |
PKCH |
0.829 | 0.003 | 2 | 0.622 |
ACVR2B |
0.829 | 0.026 | -2 | 0.824 |
GSK3B |
0.828 | 0.109 | 4 | 0.535 |
PHKG1 |
0.827 | -0.057 | -3 | 0.845 |
ACVR2A |
0.827 | 0.002 | -2 | 0.809 |
CHAK1 |
0.827 | -0.055 | 2 | 0.734 |
QIK |
0.827 | -0.089 | -3 | 0.852 |
NEK2 |
0.826 | -0.093 | 2 | 0.731 |
CK1E |
0.826 | 0.039 | -3 | 0.574 |
SIK |
0.826 | -0.007 | -3 | 0.774 |
CHK1 |
0.826 | -0.013 | -3 | 0.832 |
AKT1 |
0.826 | 0.126 | -3 | 0.743 |
MPSK1 |
0.826 | 0.153 | 1 | 0.787 |
MOK |
0.826 | 0.303 | 1 | 0.840 |
CAMK1G |
0.825 | 0.018 | -3 | 0.778 |
MARK3 |
0.825 | -0.023 | 4 | 0.694 |
BRSK1 |
0.825 | -0.047 | -3 | 0.805 |
IRE2 |
0.825 | -0.093 | 2 | 0.661 |
MLK4 |
0.825 | -0.103 | 2 | 0.624 |
GRK2 |
0.824 | -0.020 | -2 | 0.745 |
DRAK1 |
0.824 | -0.030 | 1 | 0.766 |
TLK2 |
0.824 | -0.092 | 1 | 0.767 |
MST3 |
0.824 | 0.045 | 2 | 0.759 |
YSK4 |
0.824 | -0.171 | 1 | 0.751 |
MAPKAPK5 |
0.823 | -0.068 | -3 | 0.746 |
PLK3 |
0.823 | -0.098 | 2 | 0.741 |
JNK1 |
0.823 | 0.216 | 1 | 0.748 |
SMG1 |
0.823 | -0.084 | 1 | 0.761 |
SMMLCK |
0.823 | 0.056 | -3 | 0.828 |
TAO3 |
0.822 | 0.048 | 1 | 0.786 |
BMPR1A |
0.822 | 0.074 | 1 | 0.785 |
DCAMKL2 |
0.822 | 0.018 | -3 | 0.822 |
CDK6 |
0.821 | 0.242 | 1 | 0.765 |
PLK4 |
0.821 | -0.106 | 2 | 0.591 |
BRSK2 |
0.820 | -0.103 | -3 | 0.836 |
P70S6K |
0.820 | 0.038 | -3 | 0.731 |
PAK5 |
0.820 | 0.086 | -2 | 0.720 |
PAK4 |
0.820 | 0.099 | -2 | 0.729 |
NEK5 |
0.820 | -0.055 | 1 | 0.804 |
BRAF |
0.819 | -0.094 | -4 | 0.829 |
DAPK3 |
0.819 | 0.120 | -3 | 0.814 |
MARK2 |
0.819 | -0.081 | 4 | 0.661 |
CAMK1D |
0.819 | 0.060 | -3 | 0.721 |
WNK4 |
0.819 | -0.069 | -2 | 0.899 |
LKB1 |
0.818 | 0.075 | -3 | 0.844 |
CK1D |
0.818 | 0.043 | -3 | 0.528 |
PKCT |
0.818 | 0.014 | 2 | 0.631 |
CDK4 |
0.818 | 0.237 | 1 | 0.749 |
GAK |
0.818 | 0.076 | 1 | 0.840 |
SGK1 |
0.817 | 0.139 | -3 | 0.646 |
MEK5 |
0.817 | -0.215 | 2 | 0.755 |
PINK1 |
0.817 | -0.093 | 1 | 0.848 |
MEKK3 |
0.817 | -0.164 | 1 | 0.795 |
AKT3 |
0.817 | 0.135 | -3 | 0.664 |
PKCE |
0.817 | 0.079 | 2 | 0.632 |
PKCI |
0.816 | 0.027 | 2 | 0.653 |
MARK1 |
0.816 | -0.085 | 4 | 0.722 |
SNRK |
0.816 | -0.199 | 2 | 0.616 |
CK1A2 |
0.815 | 0.035 | -3 | 0.532 |
IRAK4 |
0.815 | -0.072 | 1 | 0.767 |
GCK |
0.815 | 0.079 | 1 | 0.786 |
CAMKK2 |
0.814 | -0.027 | -2 | 0.796 |
MEKK1 |
0.814 | -0.185 | 1 | 0.792 |
ROCK2 |
0.814 | 0.165 | -3 | 0.812 |
ZAK |
0.814 | -0.168 | 1 | 0.764 |
MRCKA |
0.814 | 0.138 | -3 | 0.777 |
SSTK |
0.814 | -0.031 | 4 | 0.732 |
DAPK1 |
0.813 | 0.103 | -3 | 0.801 |
MEKK2 |
0.813 | -0.145 | 2 | 0.723 |
PERK |
0.813 | -0.197 | -2 | 0.859 |
CAMKK1 |
0.813 | -0.091 | -2 | 0.795 |
ERK7 |
0.812 | 0.037 | 2 | 0.453 |
MRCKB |
0.812 | 0.129 | -3 | 0.762 |
CK2A2 |
0.812 | 0.050 | 1 | 0.717 |
HRI |
0.811 | -0.238 | -2 | 0.873 |
GRK3 |
0.810 | -0.026 | -2 | 0.701 |
TNIK |
0.810 | 0.076 | 3 | 0.901 |
NEK11 |
0.810 | -0.132 | 1 | 0.777 |
TLK1 |
0.809 | -0.183 | -2 | 0.852 |
TAO2 |
0.809 | -0.069 | 2 | 0.770 |
BUB1 |
0.809 | 0.170 | -5 | 0.797 |
CK1G1 |
0.808 | -0.039 | -3 | 0.534 |
HPK1 |
0.808 | 0.034 | 1 | 0.767 |
PDHK3_TYR |
0.808 | 0.334 | 4 | 0.892 |
PDK1 |
0.808 | -0.067 | 1 | 0.765 |
PHKG2 |
0.808 | -0.079 | -3 | 0.815 |
DMPK1 |
0.806 | 0.173 | -3 | 0.784 |
NEK8 |
0.806 | -0.171 | 2 | 0.733 |
SBK |
0.806 | 0.095 | -3 | 0.608 |
HGK |
0.806 | -0.009 | 3 | 0.892 |
NEK4 |
0.805 | -0.103 | 1 | 0.761 |
KHS2 |
0.805 | 0.096 | 1 | 0.766 |
STK33 |
0.805 | -0.067 | 2 | 0.591 |
CHK2 |
0.805 | 0.039 | -3 | 0.671 |
EEF2K |
0.804 | -0.010 | 3 | 0.869 |
PBK |
0.804 | 0.076 | 1 | 0.772 |
LRRK2 |
0.804 | -0.059 | 2 | 0.772 |
KHS1 |
0.804 | 0.054 | 1 | 0.751 |
MEKK6 |
0.803 | -0.083 | 1 | 0.795 |
MINK |
0.803 | -0.033 | 1 | 0.765 |
CK2A1 |
0.803 | 0.041 | 1 | 0.697 |
LOK |
0.802 | -0.016 | -2 | 0.815 |
MAP3K15 |
0.802 | -0.073 | 1 | 0.750 |
PKN1 |
0.802 | -0.018 | -3 | 0.758 |
NEK1 |
0.801 | -0.057 | 1 | 0.771 |
MST2 |
0.801 | -0.140 | 1 | 0.791 |
CRIK |
0.800 | 0.132 | -3 | 0.740 |
TTBK1 |
0.800 | -0.222 | 2 | 0.594 |
PDHK4_TYR |
0.800 | 0.171 | 2 | 0.834 |
CAMK1A |
0.800 | 0.035 | -3 | 0.680 |
PLK2 |
0.799 | -0.059 | -3 | 0.706 |
TAK1 |
0.799 | -0.136 | 1 | 0.790 |
SLK |
0.799 | -0.041 | -2 | 0.759 |
IRAK1 |
0.799 | -0.293 | -1 | 0.773 |
VRK1 |
0.798 | -0.151 | 2 | 0.784 |
ROCK1 |
0.797 | 0.117 | -3 | 0.779 |
MAP2K4_TYR |
0.797 | 0.095 | -1 | 0.883 |
MAP2K6_TYR |
0.797 | 0.093 | -1 | 0.885 |
TESK1_TYR |
0.797 | 0.083 | 3 | 0.879 |
HASPIN |
0.797 | 0.132 | -1 | 0.820 |
MST1 |
0.797 | -0.103 | 1 | 0.766 |
LIMK2_TYR |
0.795 | 0.154 | -3 | 0.889 |
PKMYT1_TYR |
0.794 | 0.057 | 3 | 0.839 |
PKG1 |
0.793 | 0.047 | -2 | 0.654 |
BMPR2_TYR |
0.793 | 0.052 | -1 | 0.881 |
PDHK1_TYR |
0.791 | 0.016 | -1 | 0.892 |
MAP2K7_TYR |
0.791 | -0.120 | 2 | 0.805 |
YANK3 |
0.790 | -0.021 | 2 | 0.415 |
YSK1 |
0.790 | -0.104 | 2 | 0.716 |
OSR1 |
0.790 | -0.042 | 2 | 0.729 |
MEK2 |
0.787 | -0.272 | 2 | 0.750 |
PINK1_TYR |
0.786 | -0.132 | 1 | 0.829 |
CK1A |
0.784 | 0.015 | -3 | 0.434 |
EPHB4 |
0.783 | -0.011 | -1 | 0.818 |
BIKE |
0.782 | 0.017 | 1 | 0.726 |
RIPK2 |
0.782 | -0.332 | 1 | 0.720 |
TTK |
0.782 | -0.081 | -2 | 0.859 |
EPHA6 |
0.782 | -0.028 | -1 | 0.850 |
MYO3B |
0.782 | -0.035 | 2 | 0.742 |
LIMK1_TYR |
0.781 | -0.104 | 2 | 0.790 |
NEK3 |
0.780 | -0.181 | 1 | 0.746 |
RET |
0.780 | -0.137 | 1 | 0.781 |
ALPHAK3 |
0.780 | -0.059 | -1 | 0.789 |
TXK |
0.780 | 0.063 | 1 | 0.844 |
TNK2 |
0.779 | 0.031 | 3 | 0.729 |
DDR1 |
0.778 | -0.116 | 4 | 0.794 |
ASK1 |
0.778 | -0.155 | 1 | 0.735 |
ABL2 |
0.777 | -0.018 | -1 | 0.810 |
MYO3A |
0.776 | -0.089 | 1 | 0.753 |
TAO1 |
0.776 | -0.106 | 1 | 0.709 |
TYRO3 |
0.775 | -0.160 | 3 | 0.791 |
MST1R |
0.775 | -0.190 | 3 | 0.790 |
EPHA4 |
0.775 | -0.040 | 2 | 0.754 |
ROS1 |
0.774 | -0.149 | 3 | 0.760 |
YES1 |
0.773 | -0.089 | -1 | 0.826 |
FGR |
0.773 | -0.110 | 1 | 0.849 |
INSRR |
0.773 | -0.103 | 3 | 0.727 |
ITK |
0.772 | -0.048 | -1 | 0.777 |
TNK1 |
0.772 | 0.003 | 3 | 0.766 |
JAK2 |
0.772 | -0.200 | 1 | 0.777 |
TYK2 |
0.772 | -0.260 | 1 | 0.774 |
JAK3 |
0.772 | -0.143 | 1 | 0.771 |
ABL1 |
0.771 | -0.057 | -1 | 0.802 |
EPHB1 |
0.771 | -0.092 | 1 | 0.842 |
CSF1R |
0.771 | -0.170 | 3 | 0.767 |
SRMS |
0.769 | -0.109 | 1 | 0.840 |
NEK10_TYR |
0.769 | -0.078 | 1 | 0.657 |
FER |
0.769 | -0.170 | 1 | 0.853 |
AAK1 |
0.768 | 0.064 | 1 | 0.635 |
BMX |
0.768 | -0.029 | -1 | 0.717 |
EPHB3 |
0.768 | -0.101 | -1 | 0.796 |
BLK |
0.768 | -0.006 | -1 | 0.816 |
LCK |
0.768 | -0.043 | -1 | 0.809 |
EPHB2 |
0.768 | -0.083 | -1 | 0.794 |
DDR2 |
0.768 | 0.031 | 3 | 0.705 |
TNNI3K_TYR |
0.767 | -0.038 | 1 | 0.813 |
FGFR2 |
0.766 | -0.177 | 3 | 0.764 |
HCK |
0.766 | -0.143 | -1 | 0.803 |
MERTK |
0.764 | -0.112 | 3 | 0.739 |
KDR |
0.763 | -0.161 | 3 | 0.725 |
KIT |
0.763 | -0.182 | 3 | 0.766 |
AXL |
0.762 | -0.164 | 3 | 0.745 |
PDGFRB |
0.762 | -0.233 | 3 | 0.783 |
JAK1 |
0.762 | -0.105 | 1 | 0.720 |
MET |
0.762 | -0.135 | 3 | 0.758 |
STLK3 |
0.762 | -0.244 | 1 | 0.732 |
TEK |
0.761 | -0.200 | 3 | 0.718 |
EPHA7 |
0.760 | -0.100 | 2 | 0.745 |
WEE1_TYR |
0.760 | -0.114 | -1 | 0.763 |
FYN |
0.759 | -0.053 | -1 | 0.787 |
TEC |
0.758 | -0.139 | -1 | 0.715 |
FGFR1 |
0.758 | -0.238 | 3 | 0.732 |
EPHA3 |
0.757 | -0.160 | 2 | 0.720 |
PTK2B |
0.756 | -0.067 | -1 | 0.763 |
FLT3 |
0.756 | -0.267 | 3 | 0.781 |
FLT1 |
0.755 | -0.184 | -1 | 0.822 |
LTK |
0.755 | -0.185 | 3 | 0.701 |
FGFR3 |
0.754 | -0.198 | 3 | 0.737 |
BTK |
0.754 | -0.269 | -1 | 0.737 |
NTRK1 |
0.754 | -0.254 | -1 | 0.803 |
INSR |
0.754 | -0.189 | 3 | 0.715 |
ALK |
0.753 | -0.214 | 3 | 0.684 |
EPHA5 |
0.753 | -0.116 | 2 | 0.731 |
MATK |
0.752 | -0.130 | -1 | 0.763 |
PTK2 |
0.752 | -0.005 | -1 | 0.768 |
PDGFRA |
0.751 | -0.325 | 3 | 0.782 |
YANK2 |
0.751 | -0.069 | 2 | 0.425 |
CK1G3 |
0.751 | -0.042 | -3 | 0.385 |
EPHA1 |
0.750 | -0.204 | 3 | 0.734 |
PTK6 |
0.750 | -0.280 | -1 | 0.717 |
ERBB2 |
0.750 | -0.253 | 1 | 0.732 |
NTRK3 |
0.749 | -0.182 | -1 | 0.761 |
EPHA8 |
0.749 | -0.134 | -1 | 0.791 |
LYN |
0.748 | -0.183 | 3 | 0.689 |
SRC |
0.748 | -0.138 | -1 | 0.788 |
FLT4 |
0.748 | -0.273 | 3 | 0.720 |
NTRK2 |
0.747 | -0.301 | 3 | 0.721 |
FRK |
0.746 | -0.228 | -1 | 0.815 |
CSK |
0.746 | -0.186 | 2 | 0.747 |
SYK |
0.746 | -0.045 | -1 | 0.763 |
EGFR |
0.744 | -0.149 | 1 | 0.649 |
FGFR4 |
0.743 | -0.157 | -1 | 0.768 |
EPHA2 |
0.740 | -0.130 | -1 | 0.755 |
IGF1R |
0.740 | -0.171 | 3 | 0.648 |
CK1G2 |
0.737 | -0.036 | -3 | 0.466 |
ERBB4 |
0.734 | -0.124 | 1 | 0.675 |
MUSK |
0.731 | -0.226 | 1 | 0.644 |
ZAP70 |
0.727 | -0.060 | -1 | 0.712 |
FES |
0.721 | -0.199 | -1 | 0.698 |