Motif 143 (n=183)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S617 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A1X283 | SH3PXD2B | S499 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A6NKD9 | CCDC85C | S251 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A8MQ03 | CYSRT1 | S92 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| E7ERA6 | RNF223 | S19 | ochoa | RING finger protein 223 | None |
| M0QYT0 | None | S206 | ochoa | RRM domain-containing protein | None |
| O00327 | BMAL1 | S42 | ochoa|psp | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O00534 | VWA5A | S104 | ochoa | von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) | May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. |
| O14544 | SOCS6 | S106 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
| O14686 | KMT2D | S2295 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15231 | ZNF185 | S131 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43148 | RNMT | S71 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43318 | MAP3K7 | S374 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43896 | KIF1C | S990 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60281 | ZNF292 | S1163 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60307 | MAST3 | S934 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60381 | HBP1 | S422 | ochoa | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60547 | GMDS | S57 | ochoa | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}. |
| O60883 | GPR37L1 | S461 | ochoa | G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}. |
| O75363 | BCAS1 | S114 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O94842 | TOX4 | S181 | ochoa | TOX high mobility group box family member 4 | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}. |
| O94989 | ARHGEF15 | S41 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
| O95983 | MBD3 | S85 | ochoa|psp | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| P01042 | KNG1 | S390 | psp | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| P02730 | SLC4A1 | S356 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04183 | TK1 | S62 | ochoa | Thymidine kinase, cytosolic (EC 2.7.1.21) | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}. |
| P06241 | FYN | S25 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P13010 | XRCC5 | S579 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P16144 | ITGB4 | S1208 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16471 | PRLR | S428 | ochoa | Prolactin receptor (PRL-R) | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}. |
| P23508 | MCC | S316 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P25054 | APC | S2793 | ochoa|psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27448 | MARK3 | S489 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27816 | MAP4 | S156 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P32519 | ELF1 | S332 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P38159 | RBMX | S221 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38398 | BRCA1 | S1483 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41182 | BCL6 | S307 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P42356 | PI4KA | S256 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P48444 | ARCN1 | S252 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P50443 | SLC26A2 | S35 | ochoa | Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}. |
| P51798 | CLCN7 | S60 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P51811 | XK | S415 | ochoa | Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1) | Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}. |
| P54646 | PRKAA2 | S483 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P78312 | FAM193A | S982 | ochoa | Protein FAM193A (Protein IT14) | None |
| P85299 | PRR5 | S309 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| P98182 | ZNF200 | S181 | ochoa | Zinc finger protein 200 | Localizes protein arginine N-methyltransferase PRMT3 to the nucleus. {ECO:0000269|PubMed:39513743}. |
| Q00978 | IRF9 | S252 | psp | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}. |
| Q02543 | RPL18A | S57 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q02641 | CACNB1 | S191 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q03188 | CENPC | S732 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08999 | RBL2 | S972 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q09666 | AHNAK | S5499 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0VF96 | CGNL1 | S414 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q10587 | TEF | S136 | ochoa | Thyrotroph embryonic factor | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. |
| Q10713 | PMPCA | S34 | ochoa | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:25808372}. |
| Q12888 | TP53BP1 | S359 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S482 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13011 | ECH1 | S36 | ochoa | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| Q13322 | GRB10 | S133 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13347 | EIF3I | S301 | ochoa | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q13469 | NFATC2 | S794 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13671 | RIN1 | S291 | ochoa|psp | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q13796 | SHROOM2 | S230 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14653 | IRF3 | S385 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14980 | NUMA1 | S1882 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15052 | ARHGEF6 | S561 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15717 | ELAVL1 | S99 | ochoa | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q16625 | OCLN | S340 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16665 | HIF1A | S760 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q27J81 | INF2 | S1076 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2LD37 | BLTP1 | S2726 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2LD37 | BLTP1 | S4612 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4G0X9 | CCDC40 | S214 | ochoa | Coiled-coil domain-containing protein 40 | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}. |
| Q5SW79 | CEP170 | S1041 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T9C2 | EEIG1 | S185 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5UIP0 | RIF1 | S1199 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S744 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUB5 | FAM171A1 | S564 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VY43 | PEAR1 | S795 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q63HR2 | TNS2 | S902 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68D10 | SPTY2D1 | S470 | ochoa | Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) | Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}. |
| Q6H8Q1 | ABLIM2 | S363 | ochoa | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| Q6NV74 | CRACDL | S333 | ochoa | CRACD-like protein | None |
| Q6P0Q8 | MAST2 | S1088 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P1L5 | FAM117B | S219 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2E9 | EDC4 | S37 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6W2J9 | BCOR | S586 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6XZF7 | DNMBP | S482 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6XZF7 | DNMBP | S1429 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6Y2X3 | DNAJC14 | S187 | ochoa | DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) | Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}. |
| Q6Y7W6 | GIGYF2 | S19 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q76L83 | ASXL2 | S570 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7KZ85 | SUPT6H | S1525 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7Z5H3 | ARHGAP22 | S394 | ochoa | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
| Q7Z6B7 | SRGAP1 | S940 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86UE4 | MTDH | S294 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86VM9 | ZC3H18 | S790 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VQ1 | GLCCI1 | S171 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86YD5 | LDLRAD3 | S309 | ochoa | Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) | May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}. |
| Q8IVF2 | AHNAK2 | S280 | ochoa | Protein AHNAK2 | None |
| Q8IVT2 | MISP | S155 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWU2 | LMTK2 | S616 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IX01 | SUGP2 | S824 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IXQ4 | GPALPP1 | S140 | ochoa | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | None |
| Q8IY92 | SLX4 | S1243 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZ41 | RASEF | S405 | ochoa | Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) | Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
| Q8IZW8 | TNS4 | S385 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N3V7 | SYNPO | S863 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N7R7 | CCNYL1 | S121 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8NC96 | NECAP1 | S201 | ochoa | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | Involved in endocytosis. {ECO:0000250}. |
| Q8ND76 | CCNY | S99 | ochoa | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NFH5 | NUP35 | S99 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8NFH8 | REPS2 | S217 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TEW8 | PARD3B | S402 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF68 | ZNF384 | S268 | ochoa | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
| Q8TF74 | WIPF2 | S174 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WVM7 | STAG1 | S1067 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WVV9 | HNRNPLL | S284 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q8WWY3 | PRPF31 | S450 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q8WXD9 | CASKIN1 | S718 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q92738 | USP6NL | S594 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q969V6 | MRTFA | S113 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96A57 | TMEM230 | S23 | ochoa | Transmembrane protein 230 | Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}. |
| Q96BY7 | ATG2B | S839 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96E39 | RBMXL1 | S221 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96GY0 | ZC2HC1A | S278 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96L91 | EP400 | S3131 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96MY1 | NOL4L | S386 | ochoa | Nucleolar protein 4-like | None |
| Q96QF0 | RAB3IP | S290 | ochoa | Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}. |
| Q96T37 | RBM15 | S872 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99081 | TCF12 | S354 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99501 | GAS2L1 | S599 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99570 | PIK3R4 | S894 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q9BSW7 | SYT17 | S66 | ochoa | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) | Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9BUF5 | TUBB6 | S55 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BX66 | SORBS1 | S704 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZ72 | PITPNM2 | S399 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZF3 | OSBPL6 | S343 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
| Q9C0D6 | FHDC1 | S722 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H0B6 | KLC2 | S581 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H0K1 | SIK2 | S342 | ochoa | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H201 | EPN3 | S369 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2D6 | TRIOBP | S1227 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H6A9 | PCNX3 | S311 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6R7 | WDCP | S528 | ochoa | WD repeat and coiled-coil-containing protein | None |
| Q9H7P6 | MVB12B | S200 | ochoa | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. |
| Q9HA65 | TBC1D17 | S225 | ochoa | TBC1 domain family member 17 | Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Q9HB19 | PLEKHA2 | S321 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9HBA0 | TRPV4 | S823 | psp | Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) | Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:23136043, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}. |
| Q9HCD6 | TANC2 | S1739 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NQS7 | INCENP | S510 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQS7 | INCENP | S893 | ochoa|psp | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NSK0 | KLC4 | S565 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NWQ4 | GPATCH2L | S425 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NZQ3 | NCKIPSD | S119 | ochoa | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| Q9UBF9 | MYOT | S29 | ochoa | Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein) | Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. {ECO:0000269|PubMed:12499399}. |
| Q9UK59 | DBR1 | S478 | ochoa | Lariat debranching enzyme (EC 3.1.4.-) | Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}. |
| Q9UKN1 | MUC12 | S1615 | ochoa | Mucin-12 (MUC-12) (Mucin-11) (MUC-11) | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
| Q9UKY1 | ZHX1 | S542 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UNK9 | ANGEL1 | S37 | ochoa | Protein angel homolog 1 | None |
| Q9UPN3 | MACF1 | S7278 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPQ0 | LIMCH1 | S656 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPU7 | TBC1D2B | S321 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UPY3 | DICER1 | S1141 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9Y228 | TRAF3IP3 | S110 | ochoa | TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) | Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}. |
| Q9Y2H9 | MAST1 | S951 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2K9 | STXBP5L | S771 | psp | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}. |
| Q9Y3S1 | WNK2 | Y1804 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4B5 | MTCL1 | S231 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S1148 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S1185 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| P11717 | IGF2R | S1951 | Sugiyama | Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}. |
| Q96RT7 | TUBGCP6 | S1060 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1087 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1114 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1168 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1195 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1249 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P12277 | CKB | S128 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| Q9Y4W2 | LAS1L | S641 | Sugiyama | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q01844 | EWSR1 | S273 | Sugiyama | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. {ECO:0000269|PubMed:10767297, ECO:0000269|PubMed:21256132}. |
| Q14697 | GANAB | S44 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.001887 | 2.724 |
| R-HSA-983189 | Kinesins | 0.001410 | 2.851 |
| R-HSA-74713 | IRS activation | 0.003247 | 2.489 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.004695 | 2.328 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004208 | 2.376 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.004957 | 2.305 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011791 | 1.928 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.023445 | 1.630 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.023445 | 1.630 |
| R-HSA-3560792 | Defective SLC26A2 causes chondrodysplasias | 0.034961 | 1.456 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.034961 | 1.456 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.057590 | 1.240 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.057590 | 1.240 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 0.079691 | 1.099 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.101277 | 0.994 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.021800 | 1.662 |
| R-HSA-112412 | SOS-mediated signalling | 0.111880 | 0.951 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.111880 | 0.951 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.122359 | 0.912 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.122359 | 0.912 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.132714 | 0.877 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.142948 | 0.845 |
| R-HSA-164843 | 2-LTR circle formation | 0.142948 | 0.845 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.142948 | 0.845 |
| R-HSA-4839744 | Signaling by APC mutants | 0.153062 | 0.815 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.153062 | 0.815 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.153062 | 0.815 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.153062 | 0.815 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.153062 | 0.815 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.163058 | 0.788 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.163058 | 0.788 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.163058 | 0.788 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.172936 | 0.762 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.172936 | 0.762 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.172936 | 0.762 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.172936 | 0.762 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.172936 | 0.762 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.172936 | 0.762 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.062263 | 1.206 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.192345 | 0.716 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.192345 | 0.716 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.201879 | 0.695 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.201879 | 0.695 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.211301 | 0.675 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.211301 | 0.675 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.211301 | 0.675 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.220612 | 0.656 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.220612 | 0.656 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.229814 | 0.639 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.247895 | 0.606 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.029188 | 1.535 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.256777 | 0.590 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.256777 | 0.590 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.256777 | 0.590 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.256777 | 0.590 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.256777 | 0.590 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.291272 | 0.536 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.291272 | 0.536 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.299644 | 0.523 |
| R-HSA-1221632 | Meiotic synapsis | 0.163839 | 0.786 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.307917 | 0.512 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.102083 | 0.991 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.102083 | 0.991 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.316094 | 0.500 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.340050 | 0.468 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.340050 | 0.468 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.347849 | 0.459 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.355556 | 0.449 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.355556 | 0.449 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.370699 | 0.431 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.370699 | 0.431 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.378137 | 0.422 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.249769 | 0.602 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.385488 | 0.414 |
| R-HSA-380287 | Centrosome maturation | 0.258514 | 0.588 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.392753 | 0.406 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.328242 | 0.484 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.358273 | 0.446 |
| R-HSA-3928664 | Ephrin signaling | 0.238908 | 0.622 |
| R-HSA-1538133 | G0 and Early G1 | 0.363172 | 0.440 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.182697 | 0.738 |
| R-HSA-198203 | PI3K/AKT activation | 0.142948 | 0.845 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.385488 | 0.414 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.385488 | 0.414 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.385488 | 0.414 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.079691 | 1.099 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.132714 | 0.877 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.059100 | 1.228 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.211301 | 0.675 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.347849 | 0.459 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.284756 | 0.546 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.082363 | 1.084 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.009178 | 2.037 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.079691 | 1.099 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.021800 | 1.662 |
| R-HSA-8849473 | PTK6 Expression | 0.111880 | 0.951 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.078887 | 1.103 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.220612 | 0.656 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.256777 | 0.590 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.139224 | 0.856 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.355556 | 0.449 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.370699 | 0.431 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.189275 | 0.723 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.220612 | 0.656 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.282800 | 0.549 |
| R-HSA-72086 | mRNA Capping | 0.340050 | 0.468 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.023195 | 1.635 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.079691 | 1.099 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.101277 | 0.994 |
| R-HSA-9613354 | Lipophagy | 0.132714 | 0.877 |
| R-HSA-2424491 | DAP12 signaling | 0.347849 | 0.459 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.223614 | 0.651 |
| R-HSA-5673000 | RAF activation | 0.385488 | 0.414 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.362526 | 0.441 |
| R-HSA-74749 | Signal attenuation | 0.010689 | 1.971 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.163839 | 0.786 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.146173 | 0.835 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.298759 | 0.525 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.363172 | 0.440 |
| R-HSA-5693538 | Homology Directed Repair | 0.207349 | 0.683 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.023383 | 1.631 |
| R-HSA-373753 | Nephrin family interactions | 0.256777 | 0.590 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.143269 | 0.844 |
| R-HSA-68877 | Mitotic Prometaphase | 0.013947 | 1.856 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.341165 | 0.467 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.046342 | 1.334 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.057590 | 1.240 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.079691 | 1.099 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.019717 | 1.705 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.132714 | 0.877 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.142948 | 0.845 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.142948 | 0.845 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.163058 | 0.788 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.163058 | 0.788 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.163058 | 0.788 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.182697 | 0.738 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.182697 | 0.738 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.201879 | 0.695 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.201879 | 0.695 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.229814 | 0.639 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.256777 | 0.590 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.332159 | 0.479 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.197702 | 0.704 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.340050 | 0.468 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.355556 | 0.449 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.385488 | 0.414 |
| R-HSA-1500620 | Meiosis | 0.302209 | 0.520 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.349738 | 0.456 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.054262 | 1.266 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.055099 | 1.259 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.008907 | 2.050 |
| R-HSA-112399 | IRS-mediated signalling | 0.180648 | 0.743 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.247895 | 0.606 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.132714 | 0.877 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.192345 | 0.716 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.192345 | 0.716 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.256777 | 0.590 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.057082 | 1.244 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.370699 | 0.431 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.378137 | 0.422 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.201997 | 0.695 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.307917 | 0.512 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.067014 | 1.174 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.238908 | 0.622 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.189148 | 0.723 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.122103 | 0.913 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.210617 | 0.677 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.019717 | 1.705 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.101277 | 0.994 |
| R-HSA-1483226 | Synthesis of PI | 0.153062 | 0.815 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.059100 | 1.228 |
| R-HSA-8963901 | Chylomicron remodeling | 0.182697 | 0.738 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.220612 | 0.656 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.238908 | 0.622 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.265554 | 0.576 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.340050 | 0.468 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.214942 | 0.668 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.104132 | 0.982 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.139224 | 0.856 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.223614 | 0.651 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.308424 | 0.511 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.324174 | 0.489 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.385488 | 0.414 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.392753 | 0.406 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.241034 | 0.618 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.282800 | 0.549 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.163058 | 0.788 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.220612 | 0.656 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.066621 | 1.176 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.033476 | 1.475 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.285902 | 0.544 |
| R-HSA-9664407 | Parasite infection | 0.285902 | 0.544 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.285902 | 0.544 |
| R-HSA-199991 | Membrane Trafficking | 0.014183 | 1.848 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.068706 | 1.163 |
| R-HSA-8866376 | Reelin signalling pathway | 0.079691 | 1.099 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.111880 | 0.951 |
| R-HSA-9683686 | Maturation of spike protein | 0.142948 | 0.845 |
| R-HSA-425381 | Bicarbonate transporters | 0.153062 | 0.815 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.182697 | 0.738 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.299644 | 0.523 |
| R-HSA-9839394 | TGFBR3 expression | 0.307917 | 0.512 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.254141 | 0.595 |
| R-HSA-68886 | M Phase | 0.108748 | 0.964 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.068710 | 1.163 |
| R-HSA-422475 | Axon guidance | 0.075776 | 1.120 |
| R-HSA-373752 | Netrin-1 signaling | 0.127250 | 0.895 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.220612 | 0.656 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.385488 | 0.414 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.236672 | 0.626 |
| R-HSA-1632852 | Macroautophagy | 0.289112 | 0.539 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.069723 | 1.157 |
| R-HSA-9675108 | Nervous system development | 0.105561 | 0.976 |
| R-HSA-162592 | Integration of provirus | 0.163058 | 0.788 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.245400 | 0.610 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.265554 | 0.576 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.007772 | 2.109 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.079691 | 1.099 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.090548 | 1.043 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.090548 | 1.043 |
| R-HSA-164944 | Nef and signal transduction | 0.101277 | 0.994 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.153062 | 0.815 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.153062 | 0.815 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.153062 | 0.815 |
| R-HSA-8949664 | Processing of SMDT1 | 0.182697 | 0.738 |
| R-HSA-174362 | Transport and metabolism of PAPS | 0.201879 | 0.695 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.256777 | 0.590 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.274228 | 0.562 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.291272 | 0.536 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.291272 | 0.536 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.316094 | 0.500 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.324174 | 0.489 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.157334 | 0.803 |
| R-HSA-9930044 | Nuclear RNA decay | 0.370699 | 0.431 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.349738 | 0.456 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.091937 | 1.037 |
| R-HSA-1640170 | Cell Cycle | 0.095072 | 1.022 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.123976 | 0.907 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.074334 | 1.129 |
| R-HSA-9612973 | Autophagy | 0.153626 | 0.814 |
| R-HSA-68882 | Mitotic Anaphase | 0.063627 | 1.196 |
| R-HSA-190861 | Gap junction assembly | 0.385488 | 0.414 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.258514 | 0.588 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.324174 | 0.489 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.021800 | 1.662 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.055996 | 1.252 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.220612 | 0.656 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.064654 | 1.189 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.015004 | 1.824 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.083534 | 1.078 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.172936 | 0.762 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.211301 | 0.675 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.220612 | 0.656 |
| R-HSA-71288 | Creatine metabolism | 0.256777 | 0.590 |
| R-HSA-109704 | PI3K Cascade | 0.151431 | 0.820 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.316094 | 0.500 |
| R-HSA-5621480 | Dectin-2 family | 0.180648 | 0.743 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.355556 | 0.449 |
| R-HSA-9607240 | FLT3 Signaling | 0.019999 | 1.699 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.355556 | 0.449 |
| R-HSA-9659379 | Sensory processing of sound | 0.276013 | 0.559 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.182697 | 0.738 |
| R-HSA-210990 | PECAM1 interactions | 0.153062 | 0.815 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.096711 | 1.015 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.229814 | 0.639 |
| R-HSA-6787639 | GDP-fucose biosynthesis | 0.229814 | 0.639 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.247895 | 0.606 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.176421 | 0.753 |
| R-HSA-525793 | Myogenesis | 0.316094 | 0.500 |
| R-HSA-3295583 | TRP channels | 0.316094 | 0.500 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.227961 | 0.642 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.370699 | 0.431 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.378137 | 0.422 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.339572 | 0.469 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.030981 | 1.509 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.038692 | 1.412 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.135288 | 0.869 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.249769 | 0.602 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.077250 | 1.112 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.088024 | 1.055 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.247895 | 0.606 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.274228 | 0.562 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.176421 | 0.753 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.280385 | 0.552 |
| R-HSA-9663891 | Selective autophagy | 0.319589 | 0.495 |
| R-HSA-9707616 | Heme signaling | 0.201997 | 0.695 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.158065 | 0.801 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.235811 | 0.627 |
| R-HSA-2586552 | Signaling by Leptin | 0.142948 | 0.845 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.044195 | 1.355 |
| R-HSA-1500931 | Cell-Cell communication | 0.210903 | 0.676 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.122359 | 0.912 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.201879 | 0.695 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.274228 | 0.562 |
| R-HSA-200425 | Carnitine shuttle | 0.291272 | 0.536 |
| R-HSA-73614 | Pyrimidine salvage | 0.332159 | 0.479 |
| R-HSA-69206 | G1/S Transition | 0.232012 | 0.634 |
| R-HSA-913531 | Interferon Signaling | 0.347104 | 0.460 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.100402 | 0.998 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.207349 | 0.683 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.306562 | 0.513 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.171641 | 0.765 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.270671 | 0.568 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.041409 | 1.383 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.247895 | 0.606 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.299644 | 0.523 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.295541 | 0.529 |
| R-HSA-162906 | HIV Infection | 0.171702 | 0.765 |
| R-HSA-877300 | Interferon gamma signaling | 0.160303 | 0.795 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.204309 | 0.690 |
| R-HSA-162587 | HIV Life Cycle | 0.155839 | 0.807 |
| R-HSA-8853659 | RET signaling | 0.093060 | 1.031 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.064215 | 1.192 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.135150 | 0.869 |
| R-HSA-166520 | Signaling by NTRKs | 0.314874 | 0.502 |
| R-HSA-162582 | Signal Transduction | 0.265080 | 0.577 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.157334 | 0.803 |
| R-HSA-5688426 | Deubiquitination | 0.229320 | 0.640 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.265554 | 0.576 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.307917 | 0.512 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.385488 | 0.414 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.310910 | 0.507 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.315253 | 0.501 |
| R-HSA-446728 | Cell junction organization | 0.280273 | 0.552 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.228948 | 0.640 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.047049 | 1.327 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.282800 | 0.549 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.370699 | 0.431 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.387810 | 0.411 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.082668 | 1.083 |
| R-HSA-1483255 | PI Metabolism | 0.151720 | 0.819 |
| R-HSA-3000170 | Syndecan interactions | 0.291272 | 0.536 |
| R-HSA-3000157 | Laminin interactions | 0.307917 | 0.512 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.392753 | 0.406 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.271639 | 0.566 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.385488 | 0.414 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.104132 | 0.982 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.249769 | 0.602 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.334236 | 0.476 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.291272 | 0.536 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.075460 | 1.122 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.126159 | 0.899 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.047049 | 1.327 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.291272 | 0.536 |
| R-HSA-201556 | Signaling by ALK | 0.104132 | 0.982 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.042985 | 1.367 |
| R-HSA-5619102 | SLC transporter disorders | 0.376060 | 0.425 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.162552 | 0.789 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.307917 | 0.512 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.081464 | 1.089 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.140603 | 0.852 |
| R-HSA-75153 | Apoptotic execution phase | 0.135205 | 0.869 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.238908 | 0.622 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.145319 | 0.838 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.258514 | 0.588 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.282800 | 0.549 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.242294 | 0.616 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.375219 | 0.426 |
| R-HSA-73887 | Death Receptor Signaling | 0.334236 | 0.476 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.398384 | 0.400 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.398384 | 0.400 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.399931 | 0.398 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.399931 | 0.398 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.399931 | 0.398 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.401557 | 0.396 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.404422 | 0.393 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.404725 | 0.393 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.407026 | 0.390 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.407026 | 0.390 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.407026 | 0.390 |
| R-HSA-419037 | NCAM1 interactions | 0.407026 | 0.390 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.407026 | 0.390 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.410822 | 0.386 |
| R-HSA-211000 | Gene Silencing by RNA | 0.412647 | 0.384 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.414037 | 0.383 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.414037 | 0.383 |
| R-HSA-8875878 | MET promotes cell motility | 0.414037 | 0.383 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.414361 | 0.383 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.416740 | 0.380 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.416740 | 0.380 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.420966 | 0.376 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.420966 | 0.376 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.420966 | 0.376 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.420966 | 0.376 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.424881 | 0.372 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.424881 | 0.372 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.427813 | 0.369 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.427813 | 0.369 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.427813 | 0.369 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.427813 | 0.369 |
| R-HSA-9646399 | Aggrephagy | 0.427813 | 0.369 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.427813 | 0.369 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.427813 | 0.369 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.434579 | 0.362 |
| R-HSA-9694548 | Maturation of spike protein | 0.434579 | 0.362 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.434579 | 0.362 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.434579 | 0.362 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.434579 | 0.362 |
| R-HSA-69275 | G2/M Transition | 0.439226 | 0.357 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.439226 | 0.357 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.441266 | 0.355 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.441266 | 0.355 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.441266 | 0.355 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.441266 | 0.355 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.441266 | 0.355 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.445192 | 0.351 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.445420 | 0.351 |
| R-HSA-165159 | MTOR signalling | 0.447874 | 0.349 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.447874 | 0.349 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.447874 | 0.349 |
| R-HSA-983712 | Ion channel transport | 0.448508 | 0.348 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.448944 | 0.348 |
| R-HSA-5617833 | Cilium Assembly | 0.451589 | 0.345 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.452900 | 0.344 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.452900 | 0.344 |
| R-HSA-8854214 | TBC/RABGAPs | 0.454405 | 0.343 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.454405 | 0.343 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.454662 | 0.342 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.456840 | 0.340 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.456840 | 0.340 |
| R-HSA-2172127 | DAP12 interactions | 0.460859 | 0.336 |
| R-HSA-69236 | G1 Phase | 0.460859 | 0.336 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.460859 | 0.336 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.460859 | 0.336 |
| R-HSA-190828 | Gap junction trafficking | 0.460859 | 0.336 |
| R-HSA-774815 | Nucleosome assembly | 0.467236 | 0.330 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.467236 | 0.330 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.467236 | 0.330 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.467236 | 0.330 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.467236 | 0.330 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.469922 | 0.328 |
| R-HSA-73894 | DNA Repair | 0.470416 | 0.328 |
| R-HSA-68875 | Mitotic Prophase | 0.472434 | 0.326 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.472909 | 0.325 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.473539 | 0.325 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.473539 | 0.325 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.473539 | 0.325 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.473539 | 0.325 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.473539 | 0.325 |
| R-HSA-9675135 | Diseases of DNA repair | 0.473539 | 0.325 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.473539 | 0.325 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.473539 | 0.325 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.479768 | 0.319 |
| R-HSA-437239 | Recycling pathway of L1 | 0.479768 | 0.319 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.479768 | 0.319 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.483954 | 0.315 |
| R-HSA-5620924 | Intraflagellar transport | 0.485923 | 0.313 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.485923 | 0.313 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.485923 | 0.313 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.487759 | 0.312 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.490961 | 0.309 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.492005 | 0.308 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.492005 | 0.308 |
| R-HSA-9766229 | Degradation of CDH1 | 0.492005 | 0.308 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.492005 | 0.308 |
| R-HSA-194138 | Signaling by VEGF | 0.495317 | 0.305 |
| R-HSA-69481 | G2/M Checkpoints | 0.502805 | 0.299 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.503957 | 0.298 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.503957 | 0.298 |
| R-HSA-912446 | Meiotic recombination | 0.503957 | 0.298 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.506522 | 0.295 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.509827 | 0.293 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.509827 | 0.293 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.509827 | 0.293 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.509827 | 0.293 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.513902 | 0.289 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.514897 | 0.288 |
| R-HSA-1483257 | Phospholipid metabolism | 0.514897 | 0.288 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.515629 | 0.288 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.515629 | 0.288 |
| R-HSA-1474165 | Reproduction | 0.517564 | 0.286 |
| R-HSA-72649 | Translation initiation complex formation | 0.521362 | 0.283 |
| R-HSA-9909396 | Circadian clock | 0.524835 | 0.280 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.527027 | 0.278 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.527027 | 0.278 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.532626 | 0.274 |
| R-HSA-75893 | TNF signaling | 0.532626 | 0.274 |
| R-HSA-418990 | Adherens junctions interactions | 0.537451 | 0.270 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.538159 | 0.269 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.538159 | 0.269 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.538159 | 0.269 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.543627 | 0.265 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.543627 | 0.265 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.543627 | 0.265 |
| R-HSA-8951664 | Neddylation | 0.545899 | 0.263 |
| R-HSA-191859 | snRNP Assembly | 0.549030 | 0.260 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.549030 | 0.260 |
| R-HSA-9033241 | Peroxisomal protein import | 0.549030 | 0.260 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.549030 | 0.260 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.549030 | 0.260 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.554370 | 0.256 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.554370 | 0.256 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.554370 | 0.256 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.554370 | 0.256 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.559646 | 0.252 |
| R-HSA-450294 | MAP kinase activation | 0.559646 | 0.252 |
| R-HSA-8956321 | Nucleotide salvage | 0.559646 | 0.252 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.560074 | 0.252 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.564861 | 0.248 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.564861 | 0.248 |
| R-HSA-1268020 | Mitochondrial protein import | 0.564861 | 0.248 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.564861 | 0.248 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.564861 | 0.248 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.570014 | 0.244 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.570014 | 0.244 |
| R-HSA-373755 | Semaphorin interactions | 0.570014 | 0.244 |
| R-HSA-8848021 | Signaling by PTK6 | 0.570014 | 0.244 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.570014 | 0.244 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.575046 | 0.240 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.575107 | 0.240 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.580139 | 0.236 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.580139 | 0.236 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.581453 | 0.235 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.583617 | 0.234 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.585112 | 0.233 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.585112 | 0.233 |
| R-HSA-74160 | Gene expression (Transcription) | 0.585611 | 0.232 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.586905 | 0.231 |
| R-HSA-69242 | S Phase | 0.586905 | 0.231 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.594884 | 0.226 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.594884 | 0.226 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.594884 | 0.226 |
| R-HSA-167172 | Transcription of the HIV genome | 0.594884 | 0.226 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.596651 | 0.224 |
| R-HSA-212436 | Generic Transcription Pathway | 0.599262 | 0.222 |
| R-HSA-9609507 | Protein localization | 0.603053 | 0.220 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.604426 | 0.219 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.604426 | 0.219 |
| R-HSA-448424 | Interleukin-17 signaling | 0.604426 | 0.219 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.604426 | 0.219 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.604426 | 0.219 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.609113 | 0.215 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.609113 | 0.215 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.609113 | 0.215 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.609113 | 0.215 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.609378 | 0.215 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.613375 | 0.212 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.613745 | 0.212 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.613745 | 0.212 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.613745 | 0.212 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.613745 | 0.212 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.615213 | 0.211 |
| R-HSA-9610379 | HCMV Late Events | 0.615627 | 0.211 |
| R-HSA-1280218 | Adaptive Immune System | 0.617105 | 0.210 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.618322 | 0.209 |
| R-HSA-4086398 | Ca2+ pathway | 0.618322 | 0.209 |
| R-HSA-4839726 | Chromatin organization | 0.620242 | 0.207 |
| R-HSA-597592 | Post-translational protein modification | 0.621512 | 0.207 |
| R-HSA-9609646 | HCMV Infection | 0.622740 | 0.206 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.622845 | 0.206 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.624370 | 0.205 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.624857 | 0.204 |
| R-HSA-421270 | Cell-cell junction organization | 0.625227 | 0.204 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.627315 | 0.203 |
| R-HSA-109581 | Apoptosis | 0.630915 | 0.200 |
| R-HSA-5689603 | UCH proteinases | 0.631732 | 0.199 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.631732 | 0.199 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.631732 | 0.199 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.636097 | 0.196 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.640410 | 0.194 |
| R-HSA-449147 | Signaling by Interleukins | 0.648178 | 0.188 |
| R-HSA-9833482 | PKR-mediated signaling | 0.648886 | 0.188 |
| R-HSA-6806834 | Signaling by MET | 0.648886 | 0.188 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.653048 | 0.185 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.657162 | 0.182 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.657239 | 0.182 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.662882 | 0.179 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.665244 | 0.177 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.665244 | 0.177 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.665675 | 0.177 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.669214 | 0.174 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.673137 | 0.172 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.677014 | 0.169 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.680845 | 0.167 |
| R-HSA-9679506 | SARS-CoV Infections | 0.681796 | 0.166 |
| R-HSA-168255 | Influenza Infection | 0.682049 | 0.166 |
| R-HSA-156902 | Peptide chain elongation | 0.684630 | 0.165 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.690291 | 0.161 |
| R-HSA-8953854 | Metabolism of RNA | 0.690593 | 0.161 |
| R-HSA-202424 | Downstream TCR signaling | 0.692068 | 0.160 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.692598 | 0.160 |
| R-HSA-2262752 | Cellular responses to stress | 0.693475 | 0.159 |
| R-HSA-9658195 | Leishmania infection | 0.694599 | 0.158 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.694599 | 0.158 |
| R-HSA-3781865 | Diseases of glycosylation | 0.695190 | 0.158 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.695722 | 0.158 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.699332 | 0.155 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.702899 | 0.153 |
| R-HSA-391251 | Protein folding | 0.702899 | 0.153 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.702899 | 0.153 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.702899 | 0.153 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.705379 | 0.152 |
| R-HSA-2029481 | FCGR activation | 0.706425 | 0.151 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.706425 | 0.151 |
| R-HSA-1474290 | Collagen formation | 0.709909 | 0.149 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.711384 | 0.148 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.713351 | 0.147 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.713351 | 0.147 |
| R-HSA-9824446 | Viral Infection Pathways | 0.715159 | 0.146 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.716753 | 0.145 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.716753 | 0.145 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.720115 | 0.143 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.720133 | 0.143 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.723438 | 0.141 |
| R-HSA-9609690 | HCMV Early Events | 0.724911 | 0.140 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.725485 | 0.139 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.726720 | 0.139 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.726720 | 0.139 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.726720 | 0.139 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.726720 | 0.139 |
| R-HSA-1266738 | Developmental Biology | 0.729335 | 0.137 |
| R-HSA-195721 | Signaling by WNT | 0.729415 | 0.137 |
| R-HSA-3214847 | HATs acetylate histones | 0.729965 | 0.137 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.729965 | 0.137 |
| R-HSA-70171 | Glycolysis | 0.733171 | 0.135 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.733171 | 0.135 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.734262 | 0.134 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.736339 | 0.133 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.736339 | 0.133 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.738836 | 0.131 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.739469 | 0.131 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.739469 | 0.131 |
| R-HSA-192823 | Viral mRNA Translation | 0.742563 | 0.129 |
| R-HSA-72172 | mRNA Splicing | 0.745572 | 0.128 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.745620 | 0.127 |
| R-HSA-5357801 | Programmed Cell Death | 0.747784 | 0.126 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.748641 | 0.126 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.748641 | 0.126 |
| R-HSA-9833110 | RSV-host interactions | 0.748641 | 0.126 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.748641 | 0.126 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.754576 | 0.122 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.757491 | 0.121 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.757491 | 0.121 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.757491 | 0.121 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.760372 | 0.119 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.760372 | 0.119 |
| R-HSA-397014 | Muscle contraction | 0.762813 | 0.118 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.762813 | 0.118 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.763219 | 0.117 |
| R-HSA-202403 | TCR signaling | 0.766032 | 0.116 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.766032 | 0.116 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.771558 | 0.113 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.771558 | 0.113 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.771558 | 0.113 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.772862 | 0.112 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.774273 | 0.111 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.774890 | 0.111 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.779606 | 0.108 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.782225 | 0.107 |
| R-HSA-373760 | L1CAM interactions | 0.787371 | 0.104 |
| R-HSA-70326 | Glucose metabolism | 0.789899 | 0.102 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.789899 | 0.102 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.794864 | 0.100 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.794864 | 0.100 |
| R-HSA-73886 | Chromosome Maintenance | 0.799713 | 0.097 |
| R-HSA-3371556 | Cellular response to heat stress | 0.799713 | 0.097 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.799713 | 0.097 |
| R-HSA-72312 | rRNA processing | 0.801558 | 0.096 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.802095 | 0.096 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.802095 | 0.096 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.804448 | 0.095 |
| R-HSA-168256 | Immune System | 0.810609 | 0.091 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.811342 | 0.091 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.811342 | 0.091 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.811342 | 0.091 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.812500 | 0.090 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.813586 | 0.090 |
| R-HSA-114608 | Platelet degranulation | 0.815804 | 0.088 |
| R-HSA-9843745 | Adipogenesis | 0.826503 | 0.083 |
| R-HSA-5576891 | Cardiac conduction | 0.826503 | 0.083 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.826503 | 0.083 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.830608 | 0.081 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.838529 | 0.076 |
| R-HSA-163685 | Integration of energy metabolism | 0.838529 | 0.076 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.838529 | 0.076 |
| R-HSA-5173105 | O-linked glycosylation | 0.840451 | 0.075 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.840451 | 0.075 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.842351 | 0.075 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.842351 | 0.075 |
| R-HSA-6807070 | PTEN Regulation | 0.844228 | 0.074 |
| R-HSA-109582 | Hemostasis | 0.845483 | 0.073 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.855031 | 0.068 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.857398 | 0.067 |
| R-HSA-2187338 | Visual phototransduction | 0.860150 | 0.065 |
| R-HSA-9758941 | Gastrulation | 0.863462 | 0.064 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.865089 | 0.063 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.865182 | 0.063 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.868285 | 0.061 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.868285 | 0.061 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.871405 | 0.060 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.871999 | 0.059 |
| R-HSA-1989781 | PPARA activates gene expression | 0.872938 | 0.059 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.875949 | 0.058 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.875949 | 0.058 |
| R-HSA-9711097 | Cellular response to starvation | 0.877428 | 0.057 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.885939 | 0.053 |
| R-HSA-72306 | tRNA processing | 0.895128 | 0.048 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.898837 | 0.046 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.898837 | 0.046 |
| R-HSA-392499 | Metabolism of proteins | 0.902468 | 0.045 |
| R-HSA-2559583 | Cellular Senescence | 0.906992 | 0.042 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.915583 | 0.038 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.920441 | 0.036 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.929454 | 0.032 |
| R-HSA-112316 | Neuronal System | 0.931437 | 0.031 |
| R-HSA-168249 | Innate Immune System | 0.931677 | 0.031 |
| R-HSA-5663205 | Infectious disease | 0.951221 | 0.022 |
| R-HSA-15869 | Metabolism of nucleotides | 0.953152 | 0.021 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.953713 | 0.021 |
| R-HSA-8939211 | ESR-mediated signaling | 0.953713 | 0.021 |
| R-HSA-157118 | Signaling by NOTCH | 0.955357 | 0.020 |
| R-HSA-382551 | Transport of small molecules | 0.956085 | 0.020 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.959916 | 0.018 |
| R-HSA-418594 | G alpha (i) signalling events | 0.963784 | 0.016 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.966175 | 0.015 |
| R-HSA-416476 | G alpha (q) signalling events | 0.966581 | 0.015 |
| R-HSA-5668914 | Diseases of metabolism | 0.970477 | 0.013 |
| R-HSA-72766 | Translation | 0.971077 | 0.013 |
| R-HSA-500792 | GPCR ligand binding | 0.977052 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.977885 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 0.978339 | 0.010 |
| R-HSA-1643685 | Disease | 0.978869 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 0.980204 | 0.009 |
| R-HSA-8957322 | Metabolism of steroids | 0.983828 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 0.985143 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.986113 | 0.006 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.989925 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.990047 | 0.004 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.992195 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.994173 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996107 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.999260 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999974 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.827 | 0.233 | -3 | 0.871 |
CDC7 |
0.827 | 0.222 | 1 | 0.298 |
CLK3 |
0.825 | 0.147 | 1 | 0.184 |
COT |
0.825 | 0.161 | 2 | 0.821 |
NDR2 |
0.821 | 0.134 | -3 | 0.911 |
SKMLCK |
0.821 | 0.275 | -2 | 0.931 |
PIM3 |
0.819 | 0.152 | -3 | 0.910 |
AURC |
0.819 | 0.239 | -2 | 0.846 |
P90RSK |
0.818 | 0.181 | -3 | 0.874 |
RSK4 |
0.817 | 0.238 | -3 | 0.850 |
MOS |
0.816 | 0.139 | 1 | 0.231 |
MSK1 |
0.815 | 0.236 | -3 | 0.840 |
RSK3 |
0.815 | 0.156 | -3 | 0.866 |
BMPR1B |
0.815 | 0.340 | 1 | 0.428 |
PKACG |
0.813 | 0.169 | -2 | 0.873 |
CAMK1B |
0.813 | 0.166 | -3 | 0.919 |
NDR1 |
0.813 | 0.122 | -3 | 0.907 |
PKACB |
0.813 | 0.223 | -2 | 0.848 |
PRKD1 |
0.812 | 0.091 | -3 | 0.903 |
CLK2 |
0.812 | 0.193 | -3 | 0.848 |
PRKD2 |
0.811 | 0.122 | -3 | 0.860 |
AURA |
0.811 | 0.241 | -2 | 0.830 |
HIPK4 |
0.811 | 0.063 | 1 | 0.137 |
GRK1 |
0.811 | 0.154 | -2 | 0.774 |
MAPKAPK2 |
0.811 | 0.133 | -3 | 0.831 |
DAPK2 |
0.810 | 0.284 | -3 | 0.923 |
PRKX |
0.809 | 0.225 | -3 | 0.782 |
TBK1 |
0.809 | -0.091 | 1 | 0.173 |
MSK2 |
0.809 | 0.170 | -3 | 0.833 |
RAF1 |
0.809 | 0.039 | 1 | 0.225 |
CAMLCK |
0.809 | 0.211 | -2 | 0.932 |
P70S6KB |
0.808 | 0.156 | -3 | 0.881 |
DYRK2 |
0.808 | 0.045 | 1 | 0.132 |
LATS2 |
0.808 | 0.085 | -5 | 0.776 |
HIPK2 |
0.808 | 0.063 | 1 | 0.106 |
PAK6 |
0.807 | 0.171 | -2 | 0.872 |
MTOR |
0.807 | -0.056 | 1 | 0.172 |
PAK1 |
0.807 | 0.159 | -2 | 0.918 |
IKKB |
0.807 | -0.048 | -2 | 0.716 |
CLK4 |
0.807 | 0.168 | -3 | 0.857 |
IKKE |
0.806 | -0.101 | 1 | 0.175 |
PRPK |
0.806 | -0.024 | -1 | 0.886 |
AURB |
0.806 | 0.209 | -2 | 0.846 |
PKN3 |
0.805 | 0.063 | -3 | 0.901 |
DRAK1 |
0.805 | 0.385 | 1 | 0.426 |
MAPKAPK3 |
0.805 | 0.096 | -3 | 0.864 |
SRPK1 |
0.805 | 0.069 | -3 | 0.844 |
KIS |
0.805 | -0.013 | 1 | 0.128 |
GRK6 |
0.805 | 0.193 | 1 | 0.314 |
MYLK4 |
0.805 | 0.239 | -2 | 0.906 |
WNK1 |
0.804 | 0.031 | -2 | 0.893 |
PKN2 |
0.804 | 0.104 | -3 | 0.891 |
CDKL1 |
0.804 | 0.081 | -3 | 0.883 |
TGFBR1 |
0.804 | 0.206 | -2 | 0.755 |
CAMK2A |
0.804 | 0.156 | 2 | 0.777 |
PIM1 |
0.804 | 0.119 | -3 | 0.863 |
GCN2 |
0.804 | -0.103 | 2 | 0.780 |
LATS1 |
0.803 | 0.160 | -3 | 0.931 |
CAMK2G |
0.803 | 0.010 | 2 | 0.796 |
DYRK4 |
0.803 | 0.050 | 1 | 0.121 |
MNK2 |
0.803 | 0.144 | -2 | 0.905 |
CAMK2B |
0.802 | 0.126 | 2 | 0.769 |
CAMK2D |
0.802 | 0.060 | -3 | 0.900 |
PAK3 |
0.802 | 0.122 | -2 | 0.908 |
ATR |
0.802 | -0.023 | 1 | 0.177 |
CLK1 |
0.802 | 0.136 | -3 | 0.839 |
NLK |
0.802 | -0.007 | 1 | 0.188 |
ICK |
0.802 | 0.092 | -3 | 0.910 |
TGFBR2 |
0.801 | 0.059 | -2 | 0.781 |
PKG2 |
0.801 | 0.180 | -2 | 0.836 |
CDKL5 |
0.800 | 0.056 | -3 | 0.880 |
CAMK4 |
0.800 | 0.104 | -3 | 0.886 |
MST4 |
0.800 | 0.020 | 2 | 0.771 |
DSTYK |
0.800 | -0.016 | 2 | 0.837 |
RIPK3 |
0.800 | 0.015 | 3 | 0.743 |
GRK5 |
0.799 | 0.096 | -3 | 0.850 |
HUNK |
0.799 | 0.027 | 2 | 0.802 |
ERK5 |
0.799 | -0.047 | 1 | 0.175 |
PDHK4 |
0.799 | -0.136 | 1 | 0.200 |
SGK3 |
0.799 | 0.145 | -3 | 0.848 |
PLK1 |
0.798 | 0.169 | -2 | 0.783 |
NIK |
0.798 | 0.074 | -3 | 0.920 |
ACVR2B |
0.798 | 0.251 | -2 | 0.760 |
AMPKA1 |
0.798 | 0.054 | -3 | 0.911 |
NUAK2 |
0.798 | 0.070 | -3 | 0.906 |
HIPK1 |
0.798 | 0.068 | 1 | 0.132 |
ALK4 |
0.798 | 0.170 | -2 | 0.791 |
GRK7 |
0.797 | 0.124 | 1 | 0.266 |
PKACA |
0.797 | 0.201 | -2 | 0.807 |
CDK8 |
0.797 | -0.039 | 1 | 0.136 |
PAK2 |
0.797 | 0.138 | -2 | 0.909 |
BMPR2 |
0.797 | -0.056 | -2 | 0.846 |
PKCD |
0.796 | 0.068 | 2 | 0.718 |
IKKA |
0.796 | -0.015 | -2 | 0.689 |
ACVR2A |
0.796 | 0.244 | -2 | 0.750 |
CDK19 |
0.796 | -0.032 | 1 | 0.125 |
JNK2 |
0.796 | -0.003 | 1 | 0.142 |
BMPR1A |
0.796 | 0.250 | 1 | 0.405 |
MNK1 |
0.796 | 0.128 | -2 | 0.905 |
CDK7 |
0.795 | -0.021 | 1 | 0.138 |
GRK2 |
0.795 | 0.262 | -2 | 0.678 |
SRPK2 |
0.795 | 0.068 | -3 | 0.784 |
CDK18 |
0.795 | -0.005 | 1 | 0.120 |
ULK2 |
0.795 | -0.131 | 2 | 0.757 |
CHAK2 |
0.795 | -0.024 | -1 | 0.886 |
DYRK1B |
0.795 | 0.050 | 1 | 0.132 |
AKT2 |
0.795 | 0.154 | -3 | 0.793 |
PRKD3 |
0.795 | 0.088 | -3 | 0.839 |
DYRK3 |
0.794 | 0.105 | 1 | 0.127 |
AMPKA2 |
0.794 | 0.056 | -3 | 0.893 |
TSSK2 |
0.793 | 0.071 | -5 | 0.838 |
CDK1 |
0.793 | -0.001 | 1 | 0.171 |
PDHK1 |
0.793 | -0.175 | 1 | 0.179 |
NEK6 |
0.793 | -0.072 | -2 | 0.821 |
CK2A2 |
0.793 | 0.203 | 1 | 0.376 |
DYRK1A |
0.792 | 0.060 | 1 | 0.133 |
DLK |
0.792 | 0.081 | 1 | 0.262 |
P38G |
0.792 | -0.016 | 1 | 0.129 |
MARK4 |
0.792 | -0.010 | 4 | 0.819 |
BRSK1 |
0.792 | 0.103 | -3 | 0.875 |
CDK17 |
0.792 | -0.018 | 1 | 0.127 |
TSSK1 |
0.791 | 0.053 | -3 | 0.930 |
PASK |
0.791 | 0.249 | -3 | 0.911 |
PAK5 |
0.791 | 0.151 | -2 | 0.826 |
ATM |
0.791 | -0.044 | 1 | 0.160 |
DAPK1 |
0.791 | 0.290 | -3 | 0.860 |
PAK4 |
0.790 | 0.157 | -2 | 0.837 |
RIPK1 |
0.789 | -0.049 | 1 | 0.185 |
MASTL |
0.789 | -0.082 | -2 | 0.799 |
WNK3 |
0.789 | -0.118 | 1 | 0.160 |
JNK3 |
0.789 | -0.026 | 1 | 0.133 |
P38B |
0.789 | -0.015 | 1 | 0.133 |
ULK1 |
0.788 | -0.103 | -3 | 0.814 |
GRK4 |
0.788 | -0.010 | -2 | 0.789 |
CDK14 |
0.788 | 0.020 | 1 | 0.138 |
BCKDK |
0.788 | -0.124 | -1 | 0.779 |
ALK2 |
0.788 | 0.120 | -2 | 0.770 |
NEK7 |
0.788 | -0.136 | -3 | 0.836 |
PIM2 |
0.788 | 0.117 | -3 | 0.843 |
HIPK3 |
0.788 | 0.039 | 1 | 0.118 |
PKCG |
0.788 | 0.056 | 2 | 0.671 |
SMMLCK |
0.788 | 0.203 | -3 | 0.889 |
CDK13 |
0.787 | -0.045 | 1 | 0.124 |
SRPK3 |
0.787 | 0.044 | -3 | 0.816 |
MELK |
0.787 | 0.035 | -3 | 0.885 |
CK2A1 |
0.787 | 0.213 | 1 | 0.397 |
PKCA |
0.787 | 0.053 | 2 | 0.658 |
NIM1 |
0.786 | -0.040 | 3 | 0.777 |
DAPK3 |
0.786 | 0.240 | -3 | 0.879 |
AKT1 |
0.786 | 0.148 | -3 | 0.808 |
P38A |
0.786 | -0.020 | 1 | 0.141 |
PKCB |
0.786 | 0.042 | 2 | 0.662 |
MLK1 |
0.786 | -0.097 | 2 | 0.751 |
DNAPK |
0.785 | -0.061 | 1 | 0.112 |
CAMK1G |
0.785 | 0.084 | -3 | 0.850 |
CDK12 |
0.785 | -0.034 | 1 | 0.120 |
FAM20C |
0.785 | 0.015 | 2 | 0.618 |
PLK3 |
0.784 | 0.006 | 2 | 0.776 |
ERK1 |
0.784 | -0.036 | 1 | 0.123 |
DCAMKL1 |
0.784 | 0.070 | -3 | 0.870 |
QSK |
0.784 | 0.036 | 4 | 0.784 |
CDK10 |
0.783 | 0.022 | 1 | 0.135 |
ANKRD3 |
0.783 | -0.071 | 1 | 0.207 |
CDK3 |
0.783 | -0.012 | 1 | 0.130 |
PHKG1 |
0.783 | -0.022 | -3 | 0.894 |
GRK3 |
0.783 | 0.202 | -2 | 0.637 |
PKCH |
0.782 | 0.044 | 2 | 0.663 |
P70S6K |
0.782 | 0.100 | -3 | 0.810 |
NUAK1 |
0.781 | 0.010 | -3 | 0.878 |
TTBK2 |
0.781 | -0.133 | 2 | 0.687 |
PKCZ |
0.781 | 0.009 | 2 | 0.730 |
CDK5 |
0.781 | -0.028 | 1 | 0.140 |
BRSK2 |
0.781 | -0.002 | -3 | 0.885 |
YSK4 |
0.780 | -0.070 | 1 | 0.205 |
CDK9 |
0.780 | -0.050 | 1 | 0.122 |
MARK3 |
0.780 | 0.047 | 4 | 0.740 |
QIK |
0.780 | -0.010 | -3 | 0.889 |
MLK3 |
0.780 | -0.035 | 2 | 0.671 |
MAPKAPK5 |
0.780 | 0.007 | -3 | 0.813 |
IRE1 |
0.780 | -0.099 | 1 | 0.141 |
MEK1 |
0.780 | 0.028 | 2 | 0.813 |
NEK9 |
0.780 | -0.150 | 2 | 0.785 |
P38D |
0.779 | -0.031 | 1 | 0.079 |
CAMK1D |
0.779 | 0.119 | -3 | 0.791 |
MLK2 |
0.778 | -0.123 | 2 | 0.768 |
SIK |
0.778 | 0.021 | -3 | 0.849 |
CDK16 |
0.778 | -0.017 | 1 | 0.118 |
CHK1 |
0.778 | 0.020 | -3 | 0.900 |
PLK4 |
0.778 | -0.075 | 2 | 0.656 |
MAK |
0.778 | 0.095 | -2 | 0.815 |
SNRK |
0.777 | -0.031 | 2 | 0.704 |
NEK2 |
0.776 | -0.084 | 2 | 0.773 |
DCAMKL2 |
0.776 | 0.036 | -3 | 0.888 |
PKR |
0.776 | -0.071 | 1 | 0.168 |
AKT3 |
0.776 | 0.148 | -3 | 0.737 |
ERK2 |
0.775 | -0.056 | 1 | 0.133 |
SGK1 |
0.775 | 0.147 | -3 | 0.724 |
MARK1 |
0.775 | 0.044 | 4 | 0.767 |
TLK2 |
0.774 | -0.094 | 1 | 0.168 |
MST3 |
0.774 | 0.050 | 2 | 0.778 |
SMG1 |
0.773 | -0.103 | 1 | 0.138 |
CDK2 |
0.773 | -0.029 | 1 | 0.204 |
VRK2 |
0.773 | -0.162 | 1 | 0.182 |
MARK2 |
0.773 | 0.013 | 4 | 0.696 |
CHAK1 |
0.773 | -0.110 | 2 | 0.764 |
MRCKA |
0.772 | 0.145 | -3 | 0.845 |
JNK1 |
0.772 | -0.022 | 1 | 0.143 |
MLK4 |
0.772 | -0.039 | 2 | 0.662 |
PHKG2 |
0.772 | -0.007 | -3 | 0.870 |
WNK4 |
0.771 | -0.062 | -2 | 0.878 |
PKCT |
0.771 | 0.031 | 2 | 0.667 |
IRE2 |
0.771 | -0.108 | 2 | 0.711 |
MEKK3 |
0.770 | -0.044 | 1 | 0.234 |
PKCE |
0.769 | 0.088 | 2 | 0.658 |
PKCI |
0.769 | 0.048 | 2 | 0.688 |
ROCK2 |
0.769 | 0.147 | -3 | 0.869 |
MRCKB |
0.769 | 0.137 | -3 | 0.829 |
MPSK1 |
0.768 | -0.034 | 1 | 0.131 |
BRAF |
0.768 | -0.024 | -4 | 0.821 |
PKN1 |
0.768 | 0.054 | -3 | 0.821 |
CHK2 |
0.767 | 0.103 | -3 | 0.744 |
MEK5 |
0.767 | -0.093 | 2 | 0.788 |
ZAK |
0.766 | -0.091 | 1 | 0.213 |
TAO3 |
0.766 | -0.016 | 1 | 0.209 |
MOK |
0.765 | 0.055 | 1 | 0.124 |
TLK1 |
0.765 | -0.114 | -2 | 0.775 |
SSTK |
0.765 | -0.001 | 4 | 0.791 |
CAMK1A |
0.765 | 0.105 | -3 | 0.759 |
GCK |
0.765 | 0.080 | 1 | 0.258 |
PRP4 |
0.765 | -0.032 | -3 | 0.750 |
CK1E |
0.764 | 0.005 | -3 | 0.488 |
PERK |
0.763 | -0.142 | -2 | 0.805 |
GSK3B |
0.763 | 0.027 | 4 | 0.512 |
GAK |
0.763 | 0.004 | 1 | 0.196 |
NEK11 |
0.763 | -0.046 | 1 | 0.226 |
MEKK1 |
0.763 | -0.150 | 1 | 0.177 |
DMPK1 |
0.763 | 0.172 | -3 | 0.843 |
PKG1 |
0.762 | 0.123 | -2 | 0.770 |
HPK1 |
0.762 | 0.063 | 1 | 0.253 |
GSK3A |
0.762 | 0.028 | 4 | 0.520 |
IRAK4 |
0.761 | -0.112 | 1 | 0.132 |
HRI |
0.761 | -0.175 | -2 | 0.820 |
BUB1 |
0.761 | 0.072 | -5 | 0.832 |
CDK4 |
0.760 | -0.037 | 1 | 0.111 |
NEK5 |
0.760 | -0.130 | 1 | 0.162 |
PLK2 |
0.760 | 0.018 | -3 | 0.790 |
MEKK2 |
0.760 | -0.123 | 2 | 0.760 |
PDK1 |
0.759 | -0.047 | 1 | 0.163 |
SBK |
0.757 | 0.085 | -3 | 0.690 |
LKB1 |
0.757 | -0.058 | -3 | 0.843 |
PINK1 |
0.756 | -0.163 | 1 | 0.147 |
NEK8 |
0.756 | -0.083 | 2 | 0.778 |
CRIK |
0.756 | 0.115 | -3 | 0.808 |
TTBK1 |
0.756 | -0.143 | 2 | 0.613 |
CDK6 |
0.755 | -0.052 | 1 | 0.113 |
ROCK1 |
0.755 | 0.130 | -3 | 0.841 |
CAMKK2 |
0.755 | -0.070 | -2 | 0.737 |
MAP3K15 |
0.755 | -0.076 | 1 | 0.184 |
CAMKK1 |
0.754 | -0.104 | -2 | 0.730 |
CK1A2 |
0.754 | 0.009 | -3 | 0.433 |
TAO2 |
0.754 | -0.080 | 2 | 0.791 |
MEKK6 |
0.754 | -0.069 | 1 | 0.182 |
TNIK |
0.752 | -0.045 | 3 | 0.832 |
LOK |
0.751 | -0.042 | -2 | 0.799 |
CK1D |
0.751 | -0.011 | -3 | 0.431 |
KHS1 |
0.751 | -0.020 | 1 | 0.188 |
MINK |
0.751 | -0.070 | 1 | 0.199 |
MST2 |
0.751 | -0.056 | 1 | 0.229 |
NEK4 |
0.750 | -0.131 | 1 | 0.162 |
KHS2 |
0.750 | 0.017 | 1 | 0.217 |
TAK1 |
0.750 | -0.053 | 1 | 0.210 |
HGK |
0.749 | -0.091 | 3 | 0.826 |
PBK |
0.749 | -0.050 | 1 | 0.129 |
ERK7 |
0.749 | -0.037 | 2 | 0.504 |
IRAK1 |
0.749 | -0.173 | -1 | 0.753 |
RIPK2 |
0.748 | -0.123 | 1 | 0.192 |
SLK |
0.747 | -0.046 | -2 | 0.729 |
LRRK2 |
0.747 | -0.088 | 2 | 0.817 |
NEK1 |
0.747 | -0.106 | 1 | 0.156 |
STK33 |
0.746 | -0.086 | 2 | 0.610 |
CK1G1 |
0.746 | -0.085 | -3 | 0.488 |
EEF2K |
0.746 | -0.072 | 3 | 0.791 |
PDHK3_TYR |
0.746 | 0.208 | 4 | 0.928 |
MST1 |
0.746 | -0.076 | 1 | 0.208 |
VRK1 |
0.745 | -0.090 | 2 | 0.808 |
HASPIN |
0.745 | 0.000 | -1 | 0.757 |
YSK1 |
0.743 | -0.088 | 2 | 0.748 |
MEK2 |
0.741 | -0.118 | 2 | 0.785 |
BMPR2_TYR |
0.739 | 0.206 | -1 | 0.908 |
PDHK4_TYR |
0.737 | 0.120 | 2 | 0.859 |
ASK1 |
0.736 | -0.084 | 1 | 0.182 |
TESK1_TYR |
0.736 | 0.047 | 3 | 0.878 |
MAP2K6_TYR |
0.735 | 0.138 | -1 | 0.903 |
BIKE |
0.735 | -0.054 | 1 | 0.132 |
MAP2K4_TYR |
0.735 | 0.066 | -1 | 0.892 |
OSR1 |
0.733 | -0.052 | 2 | 0.746 |
TXK |
0.733 | 0.264 | 1 | 0.365 |
PDHK1_TYR |
0.732 | 0.085 | -1 | 0.907 |
TTK |
0.732 | -0.040 | -2 | 0.800 |
MAP2K7_TYR |
0.731 | -0.053 | 2 | 0.842 |
EPHA6 |
0.731 | 0.088 | -1 | 0.877 |
YANK3 |
0.731 | -0.028 | 2 | 0.406 |
LIMK2_TYR |
0.730 | 0.003 | -3 | 0.919 |
PKMYT1_TYR |
0.730 | -0.038 | 3 | 0.852 |
EPHB4 |
0.729 | 0.082 | -1 | 0.835 |
ALPHAK3 |
0.729 | -0.063 | -1 | 0.831 |
NEK3 |
0.728 | -0.174 | 1 | 0.131 |
PINK1_TYR |
0.728 | -0.044 | 1 | 0.202 |
MYO3B |
0.728 | -0.070 | 2 | 0.772 |
TAO1 |
0.727 | -0.102 | 1 | 0.157 |
AAK1 |
0.726 | -0.037 | 1 | 0.095 |
RET |
0.726 | -0.095 | 1 | 0.162 |
CK1A |
0.725 | 0.037 | -3 | 0.335 |
MYO3A |
0.724 | -0.094 | 1 | 0.171 |
INSRR |
0.722 | 0.059 | 3 | 0.747 |
EPHB1 |
0.722 | 0.089 | 1 | 0.285 |
SRMS |
0.721 | 0.113 | 1 | 0.298 |
MST1R |
0.721 | -0.103 | 3 | 0.818 |
EPHA4 |
0.721 | 0.057 | 2 | 0.775 |
DDR1 |
0.721 | -0.045 | 4 | 0.864 |
JAK3 |
0.721 | -0.063 | 1 | 0.175 |
LIMK1_TYR |
0.720 | -0.092 | 2 | 0.822 |
STLK3 |
0.718 | -0.127 | 1 | 0.199 |
CSF1R |
0.718 | -0.072 | 3 | 0.790 |
ABL2 |
0.718 | -0.015 | -1 | 0.812 |
BMX |
0.718 | 0.109 | -1 | 0.740 |
ITK |
0.718 | 0.104 | -1 | 0.780 |
FGR |
0.718 | -0.001 | 1 | 0.239 |
ROS1 |
0.718 | -0.065 | 3 | 0.758 |
EPHB2 |
0.717 | 0.052 | -1 | 0.807 |
NEK10_TYR |
0.717 | -0.111 | 1 | 0.125 |
FER |
0.717 | 0.013 | 1 | 0.248 |
FGFR2 |
0.717 | -0.069 | 3 | 0.809 |
PTK2 |
0.717 | 0.206 | -1 | 0.830 |
PTK2B |
0.717 | 0.177 | -1 | 0.743 |
MERTK |
0.717 | 0.076 | 3 | 0.794 |
TYRO3 |
0.717 | -0.048 | 3 | 0.786 |
YES1 |
0.717 | -0.011 | -1 | 0.818 |
JAK2 |
0.717 | -0.176 | 1 | 0.150 |
TYK2 |
0.717 | -0.213 | 1 | 0.149 |
EPHB3 |
0.715 | 0.007 | -1 | 0.809 |
TNK2 |
0.715 | -0.038 | 3 | 0.766 |
EPHA7 |
0.713 | 0.050 | 2 | 0.773 |
ABL1 |
0.713 | -0.045 | -1 | 0.797 |
JAK1 |
0.713 | -0.092 | 1 | 0.151 |
KIT |
0.713 | -0.060 | 3 | 0.793 |
DDR2 |
0.712 | 0.015 | 3 | 0.736 |
AXL |
0.712 | -0.013 | 3 | 0.787 |
KDR |
0.712 | -0.060 | 3 | 0.763 |
MET |
0.712 | -0.014 | 3 | 0.795 |
TNK1 |
0.711 | -0.067 | 3 | 0.772 |
PDGFRB |
0.711 | -0.087 | 3 | 0.797 |
FYN |
0.711 | 0.041 | -1 | 0.804 |
SYK |
0.709 | 0.117 | -1 | 0.824 |
NTRK1 |
0.709 | -0.021 | -1 | 0.824 |
HCK |
0.708 | -0.065 | -1 | 0.810 |
EGFR |
0.708 | -0.030 | 1 | 0.197 |
LCK |
0.708 | -0.045 | -1 | 0.819 |
FLT1 |
0.707 | -0.046 | -1 | 0.858 |
TEC |
0.707 | 0.035 | -1 | 0.704 |
FGFR3 |
0.707 | -0.064 | 3 | 0.782 |
BLK |
0.707 | -0.035 | -1 | 0.819 |
FGFR1 |
0.707 | -0.139 | 3 | 0.775 |
EPHA3 |
0.707 | -0.001 | 2 | 0.752 |
EPHA5 |
0.707 | 0.037 | 2 | 0.767 |
NTRK3 |
0.707 | -0.000 | -1 | 0.790 |
ALK |
0.706 | -0.029 | 3 | 0.715 |
TNNI3K_TYR |
0.706 | -0.107 | 1 | 0.145 |
EPHA8 |
0.705 | 0.029 | -1 | 0.811 |
LTK |
0.705 | -0.056 | 3 | 0.746 |
ERBB2 |
0.704 | -0.078 | 1 | 0.202 |
FLT3 |
0.704 | -0.153 | 3 | 0.783 |
WEE1_TYR |
0.703 | -0.043 | -1 | 0.773 |
INSR |
0.703 | -0.037 | 3 | 0.720 |
EPHA1 |
0.703 | -0.039 | 3 | 0.776 |
TEK |
0.703 | -0.113 | 3 | 0.728 |
EPHA2 |
0.703 | 0.055 | -1 | 0.796 |
NTRK2 |
0.702 | -0.075 | 3 | 0.766 |
FLT4 |
0.701 | -0.105 | 3 | 0.758 |
FRK |
0.700 | -0.065 | -1 | 0.812 |
PDGFRA |
0.700 | -0.183 | 3 | 0.791 |
ERBB4 |
0.698 | 0.012 | 1 | 0.254 |
SRC |
0.698 | -0.022 | -1 | 0.789 |
BTK |
0.697 | -0.109 | -1 | 0.730 |
CSK |
0.697 | -0.056 | 2 | 0.776 |
FGFR4 |
0.696 | -0.064 | -1 | 0.792 |
IGF1R |
0.696 | 0.003 | 3 | 0.664 |
PTK6 |
0.695 | -0.145 | -1 | 0.721 |
MATK |
0.695 | -0.037 | -1 | 0.765 |
MUSK |
0.693 | -0.076 | 1 | 0.179 |
YANK2 |
0.692 | -0.060 | 2 | 0.412 |
LYN |
0.692 | -0.088 | 3 | 0.706 |
ZAP70 |
0.686 | 0.002 | -1 | 0.778 |
FES |
0.685 | 0.076 | -1 | 0.714 |
CK1G3 |
0.685 | -0.072 | -3 | 0.285 |
CK1G2 |
0.676 | -0.041 | -3 | 0.392 |