Motif 142 (n=185)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S244 | ochoa | Snf2 related CREBBP activator protein | None |
| A5PLL1 | ANKRD34B | S228 | ochoa | Ankyrin repeat domain-containing protein 34B | None |
| O15056 | SYNJ2 | S1137 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O43166 | SIPA1L1 | S1443 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43166 | SIPA1L1 | S1554 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43524 | FOXO3 | S280 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O75122 | CLASP2 | S994 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75179 | ANKRD17 | S2045 | ochoa|psp | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O76094 | SRP72 | S611 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94868 | FCHSD2 | Y667 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94875 | SORBS2 | S288 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95425 | SVIL | S231 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95935 | TBX18 | S117 | ochoa | T-box transcription factor TBX18 (T-box protein 18) | Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. {ECO:0000250|UniProtKB:Q9EPZ6, ECO:0000269|PubMed:26235987}. |
| P02671 | FGA | S274 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04049 | RAF1 | S296 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04233 | CD74 | S25 | ochoa|psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
| P10636 | MAPT | S400 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1591 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11362 | FGFR1 | Y766 | psp | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P12755 | SKI | S383 | ochoa|psp | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P14317 | HCLS1 | S314 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14550 | AKR1A1 | S211 | ochoa | Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318, PubMed:30538128). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:11306097, PubMed:18276838). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838, ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033}. |
| P15336 | ATF2 | S314 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P15884 | TCF4 | S333 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P15923 | TCF3 | S341 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16144 | ITGB4 | T1463 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17302 | GJA1 | S262 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P18583 | SON | S1697 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19634 | SLC9A1 | S785 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P19838 | NFKB1 | S893 | ochoa|psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P21802 | FGFR2 | Y769 | psp | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
| P25054 | APC | S2459 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P29692 | EEF1D | S133 | ochoa|psp | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P37275 | ZEB1 | S572 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P42566 | EPS15 | S681 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46821 | MAP1B | S1345 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49790 | NUP153 | S246 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51608 | MECP2 | S164 | ochoa|psp | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P52746 | ZNF142 | S991 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P54725 | RAD23A | S92 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P55055 | NR1H2 | S27 | ochoa | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}. |
| P85037 | FOXK1 | S243 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P98088 | MUC5AC | S1618 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| Q00613 | HSF1 | S303 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01167 | FOXK2 | S199 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q03164 | KMT2A | S3518 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S885 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12789 | GTF3C1 | S1845 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12888 | TP53BP1 | S366 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13115 | DUSP4 | S345 | ochoa | Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}. |
| Q13153 | PAK1 | S156 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13546 | RIPK1 | S346 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13835 | PKP1 | S188 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14160 | SCRIB | S1295 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14181 | POLA2 | S141 | ochoa | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}. |
| Q14202 | ZMYM3 | S172 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14596 | NBR1 | S116 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14687 | GSE1 | S84 | ochoa | Genetic suppressor element 1 | None |
| Q15555 | MAPRE2 | S209 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q32P44 | EML3 | T187 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q504U0 | C4orf46 | S19 | ochoa | Renal cancer differentiation gene 1 protein | None |
| Q53H80 | AKIRIN2 | S111 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q5R3F8 | ELFN2 | S636 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| Q5SYE7 | NHSL1 | S723 | ochoa | NHS-like protein 1 | None |
| Q5T011 | SZT2 | S2122 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T1M5 | FKBP15 | S965 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5THJ4 | VPS13D | S1707 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VT06 | CEP350 | S1245 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S1197 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZK9 | CARMIL1 | S1080 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q5VZK9 | CARMIL1 | S1261 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q641Q2 | WASHC2A | S991 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q659C4 | LARP1B | S593 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q6ICG6 | KIAA0930 | S276 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6IQ23 | PLEKHA7 | S366 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6P1R3 | MSANTD2 | S37 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6PKG0 | LARP1 | S774 | ochoa|psp | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZN55 | ZNF574 | S717 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZRS2 | SRCAP | S263 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRV2 | FAM83H | S903 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S914 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZS17 | RIPOR1 | S711 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZSS7 | MFSD6 | S755 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
| Q6ZW31 | SYDE1 | S224 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70E73 | RAPH1 | S980 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7Z2Z1 | TICRR | S1346 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z5J4 | RAI1 | S1122 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6L1 | TECPR1 | S418 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86SQ0 | PHLDB2 | S95 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86WB0 | ZC3HC1 | S381 | ochoa|psp | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86YP4 | GATAD2A | S100 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IUC6 | TICAM1 | S212 | ochoa | TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta) | Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:35215908}. |
| Q8IUW5 | RELL1 | S247 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IX15 | HOMEZ | S317 | ochoa | Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) | May function as a transcriptional regulator. |
| Q8IXZ2 | ZC3H3 | S918 | ochoa | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. |
| Q8N183 | NDUFAF2 | S149 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8N1G0 | ZNF687 | S129 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N205 | SYNE4 | S331 | ochoa | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}. |
| Q8ND04 | SMG8 | T657 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8ND30 | PPFIBP2 | S476 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8NDX1 | PSD4 | S120 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NDX5 | PHC3 | S287 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEZ4 | KMT2C | S2291 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NF50 | DOCK8 | Y937 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFH8 | REPS2 | S550 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TBC3 | SHKBP1 | S636 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
| Q8TD55 | PLEKHO2 | S390 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDM6 | DLG5 | S1265 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDY2 | RB1CC1 | S667 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TF76 | HASPIN | S165 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WWM7 | ATXN2L | S424 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WXI7 | MUC16 | S9568 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92610 | ZNF592 | S680 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92793 | CREBBP | S2065 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92888 | ARHGEF1 | S267 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q969H4 | CNKSR1 | S300 | ochoa | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | May function as an adapter protein or regulator of Ras signaling pathways. |
| Q969V6 | MRTFA | S113 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96BT3 | CENPT | S184 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96D71 | REPS1 | S390 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96E09 | PABIR1 | S62 | ochoa | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}. |
| Q96EZ8 | MCRS1 | S92 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96GU1 | PAGE5 | S30 | ochoa | P antigen family member 5 (PAGE-5) (Cancer/testis antigen 16.1) (CT16.1) (G antigen family E member 1) (Prostate-associated gene 5 protein) | None |
| Q96HS1 | PGAM5 | S171 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96JH7 | VCPIP1 | S747 | ochoa|psp | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96JM3 | CHAMP1 | S131 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S476 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JN0 | LCOR | S101 | ochoa | Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}. |
| Q96MY1 | NOL4L | S378 | ochoa | Nucleolar protein 4-like | None |
| Q96PK6 | RBM14 | S560 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96RG2 | PASK | S109 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RT1 | ERBIN | S1106 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96T17 | MAP7D2 | S273 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96T17 | MAP7D2 | S290 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96T58 | SPEN | S836 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S348 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99501 | GAS2L1 | S292 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99501 | GAS2L1 | S606 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99759 | MAP3K3 | S145 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9BTL3 | RAMAC | S86 | ochoa | RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM) | Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). {ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871}. |
| Q9BZF1 | OSBPL8 | T54 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9BZQ8 | NIBAN1 | S582 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9C0B0 | UNK | S565 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9GZM8 | NDEL1 | S231 | ochoa|psp | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9H0K1 | SIK2 | S545 | ochoa | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H5V7 | IKZF5 | S298 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
| Q9H6F5 | CCDC86 | S47 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6K5 | PRR36 | S251 | ochoa | Proline-rich protein 36 | None |
| Q9H792 | PEAK1 | S719 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HBD1 | RC3H2 | S794 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NQ75 | CASS4 | S94 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NRR5 | UBQLN4 | S100 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NY27 | PPP4R2 | S159 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NYB9 | ABI2 | S216 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NZJ5 | EIF2AK3 | S845 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}. |
| Q9P1Y5 | CAMSAP3 | S487 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P203 | BTBD7 | S998 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
| Q9P206 | NHSL3 | S520 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P2B4 | CTTNBP2NL | S549 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9P2B4 | CTTNBP2NL | S557 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9UER7 | DAXX | S702 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UGP4 | LIMD1 | S197 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHB6 | LIMA1 | S343 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UKI8 | TLK1 | S159 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKI8 | TLK1 | S744 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULT8 | HECTD1 | S1720 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UPN3 | MACF1 | S7237 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPT8 | ZC3H4 | S1065 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPU9 | SAMD4A | S420 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UPV0 | CEP164 | S483 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQR0 | SCML2 | S583 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y250 | LZTS1 | S117 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2D8 | SSX2IP | S526 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2I7 | PIKFYVE | S20 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y4B4 | RAD54L2 | S1155 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4B5 | MTCL1 | S1388 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S711 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S1357 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S665 | psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5S2 | CDC42BPB | S1673 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y5U2 | TSSC4 | S132 | ochoa | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
| Q9Y5W9 | SNX11 | S246 | ochoa | Sorting nexin-11 | Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes (PubMed:23615901). Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation (PubMed:26818531). {ECO:0000269|PubMed:23615901, ECO:0000269|PubMed:26818531}. |
| Q9Y6J0 | CABIN1 | S1803 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6K9 | IKBKG | S377 | ochoa|psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9Y6M5 | SLC30A1 | S197 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q08J23 | NSUN2 | S383 | Sugiyama | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.489713e-07 | 6.604 |
| R-HSA-1226099 | Signaling by FGFR in disease | 1.039801e-06 | 5.983 |
| R-HSA-109704 | PI3K Cascade | 9.178181e-06 | 5.037 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.395590e-05 | 4.855 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 1.814025e-05 | 4.741 |
| R-HSA-112399 | IRS-mediated signalling | 1.895992e-05 | 4.722 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.763782e-05 | 4.558 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.609791e-05 | 4.443 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.609791e-05 | 4.443 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.935022e-05 | 4.405 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.003086e-04 | 3.999 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 9.384205e-05 | 4.028 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.208786e-04 | 3.918 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.073094e-04 | 3.683 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.075274e-04 | 3.683 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 2.960101e-04 | 3.529 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.839022e-04 | 3.547 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 3.289691e-04 | 3.483 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.409936e-04 | 3.467 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.443678e-04 | 3.463 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.038154e-04 | 3.517 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.613027e-04 | 3.583 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.030936e-04 | 3.298 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 5.612729e-04 | 3.251 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.112613e-04 | 3.214 |
| R-HSA-75153 | Apoptotic execution phase | 5.981198e-04 | 3.223 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 6.338647e-04 | 3.198 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 7.986048e-04 | 3.098 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 8.913687e-04 | 3.050 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.471472e-03 | 2.832 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 1.805720e-03 | 2.743 |
| R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 1.805720e-03 | 2.743 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 1.805720e-03 | 2.743 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.762935e-03 | 2.754 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.763523e-03 | 2.754 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.675626e-03 | 2.776 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.923629e-03 | 2.716 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.976285e-03 | 2.704 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.273510e-03 | 2.643 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.297951e-03 | 2.639 |
| R-HSA-191650 | Regulation of gap junction activity | 2.579334e-03 | 2.588 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 2.579334e-03 | 2.588 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 2.579334e-03 | 2.588 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 2.579334e-03 | 2.588 |
| R-HSA-190236 | Signaling by FGFR | 2.474125e-03 | 2.607 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.876952e-03 | 2.541 |
| R-HSA-5260271 | Diseases of Immune System | 2.876952e-03 | 2.541 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.971243e-03 | 2.527 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 3.016967e-03 | 2.520 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 3.482567e-03 | 2.458 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.397265e-03 | 2.469 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.493163e-03 | 2.457 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.271397e-03 | 2.369 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.271397e-03 | 2.369 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 4.512166e-03 | 2.346 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 4.512166e-03 | 2.346 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.785317e-03 | 2.320 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.512166e-03 | 2.346 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.573236e-03 | 2.254 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 5.664940e-03 | 2.247 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 6.937754e-03 | 2.159 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.937754e-03 | 2.159 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.937754e-03 | 2.159 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 6.937754e-03 | 2.159 |
| R-HSA-9839394 | TGFBR3 expression | 6.877125e-03 | 2.163 |
| R-HSA-109581 | Apoptosis | 7.320057e-03 | 2.135 |
| R-HSA-525793 | Myogenesis | 7.497202e-03 | 2.125 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.327534e-03 | 2.079 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 9.351538e-03 | 2.029 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.660917e-03 | 2.015 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.831259e-03 | 2.007 |
| R-HSA-450294 | MAP kinase activation | 1.086102e-02 | 1.964 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.222094e-02 | 1.913 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.144597e-02 | 1.941 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.177459e-02 | 1.929 |
| R-HSA-162582 | Signal Transduction | 1.109784e-02 | 1.955 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.231666e-02 | 1.910 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.275268e-02 | 1.894 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.316874e-02 | 1.880 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 1.316874e-02 | 1.880 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.499674e-02 | 1.824 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.499674e-02 | 1.824 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.591500e-02 | 1.798 |
| R-HSA-448424 | Interleukin-17 signaling | 1.630227e-02 | 1.788 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.550966e-02 | 1.809 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.692715e-02 | 1.771 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.692715e-02 | 1.771 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.692715e-02 | 1.771 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 1.895723e-02 | 1.722 |
| R-HSA-4641265 | Repression of WNT target genes | 1.692715e-02 | 1.771 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.692715e-02 | 1.771 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.751953e-02 | 1.756 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.702156e-02 | 1.769 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.757218e-02 | 1.755 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.751953e-02 | 1.756 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.108428e-02 | 1.676 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.966788e-02 | 1.706 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.989229e-02 | 1.701 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.175837e-02 | 1.662 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.195518e-02 | 1.658 |
| R-HSA-5357801 | Programmed Cell Death | 2.219106e-02 | 1.654 |
| R-HSA-5688426 | Deubiquitination | 2.137919e-02 | 1.670 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.315101e-02 | 1.635 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.315101e-02 | 1.635 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.315101e-02 | 1.635 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.406016e-02 | 1.619 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.429327e-02 | 1.615 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.429327e-02 | 1.615 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.429327e-02 | 1.615 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.429327e-02 | 1.615 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.429327e-02 | 1.615 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.429327e-02 | 1.615 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.561873e-02 | 1.591 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 2.561873e-02 | 1.591 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.965117e-02 | 1.528 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.965117e-02 | 1.528 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.965117e-02 | 1.528 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.802098e-02 | 1.553 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.965117e-02 | 1.528 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.802098e-02 | 1.553 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.561873e-02 | 1.591 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.511496e-02 | 1.600 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.511496e-02 | 1.600 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.728001e-02 | 1.564 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.728001e-02 | 1.564 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.965117e-02 | 1.528 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 3.050991e-02 | 1.516 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 3.050991e-02 | 1.516 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.050991e-02 | 1.516 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.176226e-02 | 1.498 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.249329e-02 | 1.488 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 3.308305e-02 | 1.480 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 3.308305e-02 | 1.480 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 3.308305e-02 | 1.480 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.589278e-02 | 1.445 |
| R-HSA-8853333 | Signaling by FGFR2 fusions | 3.621879e-02 | 1.441 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 3.621879e-02 | 1.441 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.621879e-02 | 1.441 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.621879e-02 | 1.441 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 3.621879e-02 | 1.441 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 3.621879e-02 | 1.441 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 3.621879e-02 | 1.441 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 4.712929e-02 | 1.327 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.662511e-02 | 1.331 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.662511e-02 | 1.331 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.662511e-02 | 1.331 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.165753e-02 | 1.380 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.535359e-02 | 1.343 |
| R-HSA-445144 | Signal transduction by L1 | 3.847239e-02 | 1.415 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.417029e-02 | 1.355 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.881056e-02 | 1.411 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.799928e-02 | 1.319 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.799928e-02 | 1.319 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.799928e-02 | 1.319 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.799928e-02 | 1.319 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.799928e-02 | 1.319 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.799928e-02 | 1.319 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.799928e-02 | 1.319 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.799928e-02 | 1.319 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.799928e-02 | 1.319 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 4.799928e-02 | 1.319 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.799928e-02 | 1.319 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.799928e-02 | 1.319 |
| R-HSA-4839726 | Chromatin organization | 4.996229e-02 | 1.301 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 5.015874e-02 | 1.300 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.238187e-02 | 1.281 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.238187e-02 | 1.281 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 5.325648e-02 | 1.274 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 5.325648e-02 | 1.274 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.489315e-02 | 1.260 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.579663e-02 | 1.253 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 5.963650e-02 | 1.224 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 7.113217e-02 | 1.148 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 7.113217e-02 | 1.148 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 5.642042e-02 | 1.249 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.964848e-02 | 1.224 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 6.293866e-02 | 1.201 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.204996e-02 | 1.207 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.964848e-02 | 1.224 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.248366e-02 | 1.140 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 7.113217e-02 | 1.148 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.293866e-02 | 1.201 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 5.964848e-02 | 1.224 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.248366e-02 | 1.140 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 6.969745e-02 | 1.157 |
| R-HSA-9707616 | Heme signaling | 5.615496e-02 | 1.251 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.042000e-02 | 1.219 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.042000e-02 | 1.219 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.686310e-02 | 1.114 |
| R-HSA-4791275 | Signaling by WNT in cancer | 8.025313e-02 | 1.096 |
| R-HSA-74713 | IRS activation | 8.248801e-02 | 1.084 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 8.248801e-02 | 1.084 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 8.248801e-02 | 1.084 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.047870e-01 | 0.980 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.157334e-01 | 0.937 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 1.157334e-01 | 0.937 |
| R-HSA-112412 | SOS-mediated signalling | 1.157334e-01 | 0.937 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 1.157334e-01 | 0.937 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.157334e-01 | 0.937 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.265466e-01 | 0.898 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.265466e-01 | 0.898 |
| R-HSA-196025 | Formation of annular gap junctions | 1.265466e-01 | 0.898 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.265466e-01 | 0.898 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 1.265466e-01 | 0.898 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.265466e-01 | 0.898 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.372283e-01 | 0.863 |
| R-HSA-190873 | Gap junction degradation | 1.372283e-01 | 0.863 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.372283e-01 | 0.863 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.372283e-01 | 0.863 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.477800e-01 | 0.830 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.477800e-01 | 0.830 |
| R-HSA-68952 | DNA replication initiation | 1.477800e-01 | 0.830 |
| R-HSA-4839744 | Signaling by APC mutants | 1.582033e-01 | 0.801 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.582033e-01 | 0.801 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.582033e-01 | 0.801 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.582033e-01 | 0.801 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.684997e-01 | 0.773 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.684997e-01 | 0.773 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.684997e-01 | 0.773 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.786708e-01 | 0.748 |
| R-HSA-69091 | Polymerase switching | 1.786708e-01 | 0.748 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.786708e-01 | 0.748 |
| R-HSA-69109 | Leading Strand Synthesis | 1.786708e-01 | 0.748 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.786708e-01 | 0.748 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.786708e-01 | 0.748 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.786708e-01 | 0.748 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.786708e-01 | 0.748 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.887182e-01 | 0.724 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.887182e-01 | 0.724 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.986432e-01 | 0.702 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.084474e-01 | 0.681 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.084474e-01 | 0.681 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.084474e-01 | 0.681 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.754722e-02 | 1.058 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.181323e-01 | 0.661 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.276993e-01 | 0.643 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.371498e-01 | 0.625 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.371498e-01 | 0.625 |
| R-HSA-3371568 | Attenuation phase | 1.144801e-01 | 0.941 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.645222e-01 | 0.784 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.105527e-01 | 0.956 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.105527e-01 | 0.956 |
| R-HSA-913709 | O-linked glycosylation of mucins | 2.400994e-01 | 0.620 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 9.503053e-02 | 1.022 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.887182e-01 | 0.724 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.684997e-01 | 0.773 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.276993e-01 | 0.643 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.084474e-01 | 0.681 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.079817e-01 | 0.967 |
| R-HSA-198203 | PI3K/AKT activation | 1.477800e-01 | 0.830 |
| R-HSA-3371556 | Cellular response to heat stress | 2.318632e-01 | 0.635 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.084474e-01 | 0.681 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.786708e-01 | 0.748 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.559200e-01 | 0.807 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.645222e-01 | 0.784 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.863663e-01 | 0.730 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.887182e-01 | 0.724 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.464852e-01 | 0.608 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.431908e-01 | 0.844 |
| R-HSA-75893 | TNF signaling | 1.863663e-01 | 0.730 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.582033e-01 | 0.801 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.383006e-01 | 0.859 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.632712e-01 | 0.787 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.684997e-01 | 0.773 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.575458e-01 | 0.803 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.474090e-01 | 0.831 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.265466e-01 | 0.898 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.477800e-01 | 0.830 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.684997e-01 | 0.773 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.684997e-01 | 0.773 |
| R-HSA-202670 | ERKs are inactivated | 1.684997e-01 | 0.773 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.684997e-01 | 0.773 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.684997e-01 | 0.773 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.786708e-01 | 0.748 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.084474e-01 | 0.681 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.265525e-01 | 0.645 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.446245e-01 | 0.612 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.054346e-01 | 0.977 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.157334e-01 | 0.937 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.265466e-01 | 0.898 |
| R-HSA-74749 | Signal attenuation | 1.477800e-01 | 0.830 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.371498e-01 | 0.625 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.372283e-01 | 0.863 |
| R-HSA-9930044 | Nuclear RNA decay | 8.387566e-02 | 1.076 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.604818e-01 | 0.795 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.400994e-01 | 0.620 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.225238e-01 | 0.912 |
| R-HSA-73887 | Death Receptor Signaling | 1.632712e-01 | 0.787 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 9.370571e-02 | 1.028 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.265466e-01 | 0.898 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.684997e-01 | 0.773 |
| R-HSA-9909396 | Circadian clock | 1.110184e-01 | 0.955 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.184051e-01 | 0.927 |
| R-HSA-73886 | Chromosome Maintenance | 2.318632e-01 | 0.635 |
| R-HSA-9664873 | Pexophagy | 1.477800e-01 | 0.830 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.184846e-01 | 0.926 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.318632e-01 | 0.635 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.181323e-01 | 0.661 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.276993e-01 | 0.643 |
| R-HSA-3928664 | Ephrin signaling | 2.464852e-01 | 0.608 |
| R-HSA-5689603 | UCH proteinases | 8.596083e-02 | 1.066 |
| R-HSA-195721 | Signaling by WNT | 1.993063e-01 | 0.700 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 8.387566e-02 | 1.076 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.464852e-01 | 0.608 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.053930e-01 | 0.977 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 9.370571e-02 | 1.028 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.157334e-01 | 0.937 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.265466e-01 | 0.898 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.372283e-01 | 0.863 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.372283e-01 | 0.863 |
| R-HSA-428540 | Activation of RAC1 | 1.684997e-01 | 0.773 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.786708e-01 | 0.748 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.786708e-01 | 0.748 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.786708e-01 | 0.748 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.181323e-01 | 0.661 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.372283e-01 | 0.863 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.248801e-02 | 1.084 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 8.248801e-02 | 1.084 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 9.370571e-02 | 1.028 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.372283e-01 | 0.863 |
| R-HSA-448706 | Interleukin-1 processing | 1.372283e-01 | 0.863 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.986432e-01 | 0.702 |
| R-HSA-3214847 | HATs acetylate histones | 1.546268e-01 | 0.811 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.693883e-01 | 0.771 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.876110e-01 | 0.727 |
| R-HSA-1632852 | Macroautophagy | 1.317790e-01 | 0.880 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.220490e-01 | 0.654 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 9.370571e-02 | 1.028 |
| R-HSA-5689877 | Josephin domain DUBs | 1.477800e-01 | 0.830 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.887182e-01 | 0.724 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.181323e-01 | 0.661 |
| R-HSA-5661270 | Formation of xylulose-5-phosphate | 2.276993e-01 | 0.643 |
| R-HSA-9612973 | Autophagy | 1.679782e-01 | 0.775 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.688546e-01 | 0.772 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.084474e-01 | 0.681 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.361123e-01 | 0.866 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 8.248801e-02 | 1.084 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.477800e-01 | 0.830 |
| R-HSA-202403 | TCR signaling | 1.906969e-01 | 0.720 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.739769e-02 | 1.059 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.123269e-01 | 0.673 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.123269e-01 | 0.673 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.084474e-01 | 0.681 |
| R-HSA-9663891 | Selective autophagy | 1.184051e-01 | 0.927 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.079817e-01 | 0.967 |
| R-HSA-2586552 | Signaling by Leptin | 1.477800e-01 | 0.830 |
| R-HSA-9842663 | Signaling by LTK | 1.786708e-01 | 0.748 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.031665e-01 | 0.692 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 9.503053e-02 | 1.022 |
| R-HSA-5621480 | Dectin-2 family | 1.907844e-01 | 0.719 |
| R-HSA-435354 | Zinc transporters | 1.986432e-01 | 0.702 |
| R-HSA-425410 | Metal ion SLC transporters | 1.516525e-01 | 0.819 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.085870e-01 | 0.681 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.012363e-01 | 0.995 |
| R-HSA-9758941 | Gastrulation | 1.517223e-01 | 0.819 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.612443e-01 | 0.793 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.516525e-01 | 0.819 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.775346e-01 | 0.751 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.540064e-01 | 0.812 |
| R-HSA-166520 | Signaling by NTRKs | 1.494514e-01 | 0.826 |
| R-HSA-2028269 | Signaling by Hippo | 2.371498e-01 | 0.625 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.491530e-01 | 0.604 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 2.536842e-01 | 0.596 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.557069e-01 | 0.592 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.557069e-01 | 0.592 |
| R-HSA-392517 | Rap1 signalling | 2.557069e-01 | 0.592 |
| R-HSA-9834899 | Specification of the neural plate border | 2.557069e-01 | 0.592 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.557069e-01 | 0.592 |
| R-HSA-1643685 | Disease | 2.591203e-01 | 0.586 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.621986e-01 | 0.581 |
| R-HSA-4086398 | Ca2+ pathway | 2.627516e-01 | 0.580 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.648164e-01 | 0.577 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.648164e-01 | 0.577 |
| R-HSA-1181150 | Signaling by NODAL | 2.648164e-01 | 0.577 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.648164e-01 | 0.577 |
| R-HSA-68877 | Mitotic Prometaphase | 2.648879e-01 | 0.577 |
| R-HSA-9843745 | Adipogenesis | 2.711460e-01 | 0.567 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.729866e-01 | 0.564 |
| R-HSA-449147 | Signaling by Interleukins | 2.736341e-01 | 0.563 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.738149e-01 | 0.563 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.738149e-01 | 0.563 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.738149e-01 | 0.563 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.738149e-01 | 0.563 |
| R-HSA-198753 | ERK/MAPK targets | 2.738149e-01 | 0.563 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.738149e-01 | 0.563 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.738149e-01 | 0.563 |
| R-HSA-9679506 | SARS-CoV Infections | 2.794757e-01 | 0.554 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.827038e-01 | 0.549 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.827038e-01 | 0.549 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.827038e-01 | 0.549 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.827038e-01 | 0.549 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.827038e-01 | 0.549 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.827038e-01 | 0.549 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.827038e-01 | 0.549 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.827038e-01 | 0.549 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.910688e-01 | 0.536 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.914845e-01 | 0.535 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.914845e-01 | 0.535 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.914845e-01 | 0.535 |
| R-HSA-9833482 | PKR-mediated signaling | 2.944691e-01 | 0.531 |
| R-HSA-212436 | Generic Transcription Pathway | 2.945613e-01 | 0.531 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.989892e-01 | 0.524 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.989892e-01 | 0.524 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.001582e-01 | 0.523 |
| R-HSA-3000170 | Syndecan interactions | 3.001582e-01 | 0.523 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.001582e-01 | 0.523 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.001582e-01 | 0.523 |
| R-HSA-6807070 | PTEN Regulation | 3.010722e-01 | 0.521 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.024976e-01 | 0.519 |
| R-HSA-446728 | Cell junction organization | 3.052594e-01 | 0.515 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.087263e-01 | 0.510 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.087263e-01 | 0.510 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.087263e-01 | 0.510 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.125202e-01 | 0.505 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.170188e-01 | 0.499 |
| R-HSA-9620244 | Long-term potentiation | 3.171900e-01 | 0.499 |
| R-HSA-2160916 | Hyaluronan degradation | 3.171900e-01 | 0.499 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.171900e-01 | 0.499 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.171900e-01 | 0.499 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.171900e-01 | 0.499 |
| R-HSA-3000157 | Laminin interactions | 3.171900e-01 | 0.499 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.171900e-01 | 0.499 |
| R-HSA-3295583 | TRP channels | 3.255505e-01 | 0.487 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.255505e-01 | 0.487 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.304727e-01 | 0.481 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.338092e-01 | 0.477 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.338092e-01 | 0.477 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.338092e-01 | 0.477 |
| R-HSA-201451 | Signaling by BMP | 3.338092e-01 | 0.477 |
| R-HSA-418990 | Adherens junctions interactions | 3.361588e-01 | 0.473 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.394019e-01 | 0.469 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.419673e-01 | 0.466 |
| R-HSA-622312 | Inflammasomes | 3.419673e-01 | 0.466 |
| R-HSA-202424 | Downstream TCR signaling | 3.438531e-01 | 0.464 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.445339e-01 | 0.463 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.478746e-01 | 0.459 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.500260e-01 | 0.456 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.500260e-01 | 0.456 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.545509e-01 | 0.450 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.579865e-01 | 0.446 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.579865e-01 | 0.446 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.579865e-01 | 0.446 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.579865e-01 | 0.446 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.579865e-01 | 0.446 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.579865e-01 | 0.446 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.579865e-01 | 0.446 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.623094e-01 | 0.441 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.658500e-01 | 0.437 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.658500e-01 | 0.437 |
| R-HSA-182971 | EGFR downregulation | 3.658500e-01 | 0.437 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.658500e-01 | 0.437 |
| R-HSA-69190 | DNA strand elongation | 3.736176e-01 | 0.428 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.736176e-01 | 0.428 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.736176e-01 | 0.428 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.790843e-01 | 0.421 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.790843e-01 | 0.421 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.812906e-01 | 0.419 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.812906e-01 | 0.419 |
| R-HSA-354192 | Integrin signaling | 3.812906e-01 | 0.419 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.812906e-01 | 0.419 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.812906e-01 | 0.419 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.812906e-01 | 0.419 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.812906e-01 | 0.419 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.812906e-01 | 0.419 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.812906e-01 | 0.419 |
| R-HSA-157579 | Telomere Maintenance | 3.834351e-01 | 0.416 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.877749e-01 | 0.411 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.888701e-01 | 0.410 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.888701e-01 | 0.410 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.888701e-01 | 0.410 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.920972e-01 | 0.407 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.920972e-01 | 0.407 |
| R-HSA-5673000 | RAF activation | 3.963571e-01 | 0.402 |
| R-HSA-190861 | Gap junction assembly | 3.963571e-01 | 0.402 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.963571e-01 | 0.402 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.963571e-01 | 0.402 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.963571e-01 | 0.402 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.963571e-01 | 0.402 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.963571e-01 | 0.402 |
| R-HSA-5205647 | Mitophagy | 3.963571e-01 | 0.402 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.963571e-01 | 0.402 |
| R-HSA-1500931 | Cell-Cell communication | 3.970814e-01 | 0.401 |
| R-HSA-74160 | Gene expression (Transcription) | 4.019300e-01 | 0.396 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.037529e-01 | 0.394 |
| R-HSA-381042 | PERK regulates gene expression | 4.037529e-01 | 0.394 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.049873e-01 | 0.393 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.049873e-01 | 0.393 |
| R-HSA-1483255 | PI Metabolism | 4.049873e-01 | 0.393 |
| R-HSA-3371511 | HSF1 activation | 4.110586e-01 | 0.386 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.110586e-01 | 0.386 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.110586e-01 | 0.386 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.110586e-01 | 0.386 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.110586e-01 | 0.386 |
| R-HSA-8853659 | RET signaling | 4.110586e-01 | 0.386 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.110586e-01 | 0.386 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.135083e-01 | 0.384 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.140191e-01 | 0.383 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.177463e-01 | 0.379 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.177463e-01 | 0.379 |
| R-HSA-9833110 | RSV-host interactions | 4.177463e-01 | 0.379 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.182751e-01 | 0.379 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.182751e-01 | 0.379 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.219688e-01 | 0.375 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.254037e-01 | 0.371 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.254037e-01 | 0.371 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.261757e-01 | 0.370 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.270812e-01 | 0.369 |
| R-HSA-421270 | Cell-cell junction organization | 4.273773e-01 | 0.369 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.324454e-01 | 0.364 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.324454e-01 | 0.364 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.324454e-01 | 0.364 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.324454e-01 | 0.364 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.324454e-01 | 0.364 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.324454e-01 | 0.364 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.324454e-01 | 0.364 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.345416e-01 | 0.362 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.345416e-01 | 0.362 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.394012e-01 | 0.357 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.394012e-01 | 0.357 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.394012e-01 | 0.357 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.394012e-01 | 0.357 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.394012e-01 | 0.357 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.394012e-01 | 0.357 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.394012e-01 | 0.357 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.394012e-01 | 0.357 |
| R-HSA-9646399 | Aggrephagy | 4.394012e-01 | 0.357 |
| R-HSA-202433 | Generation of second messenger molecules | 4.394012e-01 | 0.357 |
| R-HSA-2559583 | Cellular Senescence | 4.432077e-01 | 0.353 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.462722e-01 | 0.350 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.462722e-01 | 0.350 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.462722e-01 | 0.350 |
| R-HSA-9607240 | FLT3 Signaling | 4.462722e-01 | 0.350 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.464200e-01 | 0.350 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.530593e-01 | 0.344 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.530593e-01 | 0.344 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.530593e-01 | 0.344 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.592394e-01 | 0.338 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.597637e-01 | 0.337 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.597637e-01 | 0.337 |
| R-HSA-9710421 | Defective pyroptosis | 4.663864e-01 | 0.331 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.663864e-01 | 0.331 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.713534e-01 | 0.327 |
| R-HSA-190828 | Gap junction trafficking | 4.729282e-01 | 0.325 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.729282e-01 | 0.325 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.729282e-01 | 0.325 |
| R-HSA-373760 | L1CAM interactions | 4.753553e-01 | 0.323 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.793390e-01 | 0.319 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.793903e-01 | 0.319 |
| R-HSA-774815 | Nucleosome assembly | 4.793903e-01 | 0.319 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.793903e-01 | 0.319 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.793903e-01 | 0.319 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.793903e-01 | 0.319 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.795931e-01 | 0.319 |
| R-HSA-5693538 | Homology Directed Repair | 4.833042e-01 | 0.316 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.857735e-01 | 0.314 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.857735e-01 | 0.314 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.857735e-01 | 0.314 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.857735e-01 | 0.314 |
| R-HSA-9609690 | HCMV Early Events | 4.935364e-01 | 0.307 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.950879e-01 | 0.305 |
| R-HSA-168249 | Innate Immune System | 4.958600e-01 | 0.305 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.983073e-01 | 0.303 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.983073e-01 | 0.303 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.044597e-01 | 0.297 |
| R-HSA-9766229 | Degradation of CDH1 | 5.044597e-01 | 0.297 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.143464e-01 | 0.289 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.143464e-01 | 0.289 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.143464e-01 | 0.289 |
| R-HSA-194138 | Signaling by VEGF | 5.143464e-01 | 0.289 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.148485e-01 | 0.288 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.165402e-01 | 0.287 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.165402e-01 | 0.287 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.224701e-01 | 0.282 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.224701e-01 | 0.282 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.283277e-01 | 0.277 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.283277e-01 | 0.277 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.398292e-01 | 0.268 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.398292e-01 | 0.268 |
| R-HSA-1640170 | Cell Cycle | 5.425127e-01 | 0.266 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.454749e-01 | 0.263 |
| R-HSA-177929 | Signaling by EGFR | 5.454749e-01 | 0.263 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.454749e-01 | 0.263 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.510516e-01 | 0.259 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.510516e-01 | 0.259 |
| R-HSA-68886 | M Phase | 5.537608e-01 | 0.257 |
| R-HSA-1280218 | Adaptive Immune System | 5.541921e-01 | 0.256 |
| R-HSA-913531 | Interferon Signaling | 5.559628e-01 | 0.255 |
| R-HSA-68882 | Mitotic Anaphase | 5.559977e-01 | 0.255 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.565603e-01 | 0.254 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.588573e-01 | 0.253 |
| R-HSA-191859 | snRNP Assembly | 5.620017e-01 | 0.250 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.620017e-01 | 0.250 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.620017e-01 | 0.250 |
| R-HSA-180786 | Extension of Telomeres | 5.620017e-01 | 0.250 |
| R-HSA-186712 | Regulation of beta-cell development | 5.620017e-01 | 0.250 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.620017e-01 | 0.250 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.621092e-01 | 0.250 |
| R-HSA-5173105 | O-linked glycosylation | 5.656420e-01 | 0.247 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.656420e-01 | 0.247 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.673767e-01 | 0.246 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.673767e-01 | 0.246 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.673767e-01 | 0.246 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.673767e-01 | 0.246 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.673767e-01 | 0.246 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.673767e-01 | 0.246 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.673767e-01 | 0.246 |
| R-HSA-156590 | Glutathione conjugation | 5.673767e-01 | 0.246 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.726860e-01 | 0.242 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.760149e-01 | 0.240 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.779305e-01 | 0.238 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.779305e-01 | 0.238 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.779305e-01 | 0.238 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.779305e-01 | 0.238 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.779305e-01 | 0.238 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.795688e-01 | 0.237 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.831110e-01 | 0.234 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.831110e-01 | 0.234 |
| R-HSA-6799198 | Complex I biogenesis | 5.831110e-01 | 0.234 |
| R-HSA-373755 | Semaphorin interactions | 5.831110e-01 | 0.234 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.831110e-01 | 0.234 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.854568e-01 | 0.233 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.931674e-01 | 0.227 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.982759e-01 | 0.223 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.982759e-01 | 0.223 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.032078e-01 | 0.220 |
| R-HSA-5218859 | Regulated Necrosis | 6.080796e-01 | 0.216 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.129486e-01 | 0.213 |
| R-HSA-8939211 | ESR-mediated signaling | 6.136698e-01 | 0.212 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.176452e-01 | 0.209 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.193780e-01 | 0.208 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.223405e-01 | 0.206 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.223405e-01 | 0.206 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.225619e-01 | 0.206 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.269785e-01 | 0.203 |
| R-HSA-168256 | Immune System | 6.283464e-01 | 0.202 |
| R-HSA-1989781 | PPARA activates gene expression | 6.288683e-01 | 0.201 |
| R-HSA-2262752 | Cellular responses to stress | 6.299043e-01 | 0.201 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.315598e-01 | 0.200 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.315598e-01 | 0.200 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.315598e-01 | 0.200 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.350929e-01 | 0.197 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.360851e-01 | 0.196 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.360851e-01 | 0.196 |
| R-HSA-9711097 | Cellular response to starvation | 6.381746e-01 | 0.195 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.381746e-01 | 0.195 |
| R-HSA-380287 | Centrosome maturation | 6.405551e-01 | 0.193 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.405551e-01 | 0.193 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.405551e-01 | 0.193 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.405551e-01 | 0.193 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.442771e-01 | 0.191 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.449705e-01 | 0.190 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.449705e-01 | 0.190 |
| R-HSA-9609646 | HCMV Infection | 6.467739e-01 | 0.189 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.493319e-01 | 0.188 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.536400e-01 | 0.185 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.536400e-01 | 0.185 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.536400e-01 | 0.185 |
| R-HSA-4086400 | PCP/CE pathway | 6.536400e-01 | 0.185 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.536400e-01 | 0.185 |
| R-HSA-216083 | Integrin cell surface interactions | 6.536400e-01 | 0.185 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.578954e-01 | 0.182 |
| R-HSA-6806834 | Signaling by MET | 6.620988e-01 | 0.179 |
| R-HSA-977225 | Amyloid fiber formation | 6.662508e-01 | 0.176 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.703521e-01 | 0.174 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.703521e-01 | 0.174 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.744032e-01 | 0.171 |
| R-HSA-72306 | tRNA processing | 6.764003e-01 | 0.170 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.778334e-01 | 0.169 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.784048e-01 | 0.169 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.847435e-01 | 0.164 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.874854e-01 | 0.163 |
| R-HSA-73894 | DNA Repair | 6.891290e-01 | 0.162 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.892326e-01 | 0.162 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.901183e-01 | 0.161 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.902078e-01 | 0.161 |
| R-HSA-70268 | Pyruvate metabolism | 6.939277e-01 | 0.159 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.950061e-01 | 0.158 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.976904e-01 | 0.156 |
| R-HSA-6798695 | Neutrophil degranulation | 7.021422e-01 | 0.154 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.050785e-01 | 0.152 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.087049e-01 | 0.150 |
| R-HSA-3781865 | Diseases of glycosylation | 7.138427e-01 | 0.146 |
| R-HSA-1266738 | Developmental Biology | 7.146747e-01 | 0.146 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.158251e-01 | 0.145 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.158251e-01 | 0.145 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.158251e-01 | 0.145 |
| R-HSA-69275 | G2/M Transition | 7.188861e-01 | 0.143 |
| R-HSA-112316 | Neuronal System | 7.207716e-01 | 0.142 |
| R-HSA-1474290 | Collagen formation | 7.227721e-01 | 0.141 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.238550e-01 | 0.140 |
| R-HSA-983712 | Ion channel transport | 7.263117e-01 | 0.139 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.339371e-01 | 0.134 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.361632e-01 | 0.133 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.394092e-01 | 0.131 |
| R-HSA-1483257 | Phospholipid metabolism | 7.456030e-01 | 0.127 |
| R-HSA-70171 | Glycolysis | 7.457824e-01 | 0.127 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.489106e-01 | 0.126 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.520005e-01 | 0.124 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.520005e-01 | 0.124 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.580673e-01 | 0.120 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.588094e-01 | 0.120 |
| R-HSA-597592 | Post-translational protein modification | 7.641458e-01 | 0.117 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.697613e-01 | 0.114 |
| R-HSA-69239 | Synthesis of DNA | 7.697613e-01 | 0.114 |
| R-HSA-211000 | Gene Silencing by RNA | 7.697613e-01 | 0.114 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.725959e-01 | 0.112 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.753957e-01 | 0.110 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.799415e-01 | 0.108 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.835911e-01 | 0.106 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.835911e-01 | 0.106 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.835911e-01 | 0.106 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.835911e-01 | 0.106 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.862562e-01 | 0.104 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.902825e-01 | 0.102 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.914889e-01 | 0.102 |
| R-HSA-70326 | Glucose metabolism | 8.015749e-01 | 0.096 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.015749e-01 | 0.096 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.064343e-01 | 0.093 |
| R-HSA-68875 | Mitotic Prophase | 8.088194e-01 | 0.092 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.158008e-01 | 0.088 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.158008e-01 | 0.088 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.180711e-01 | 0.087 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.180711e-01 | 0.087 |
| R-HSA-69206 | G1/S Transition | 8.225285e-01 | 0.085 |
| R-HSA-114608 | Platelet degranulation | 8.268772e-01 | 0.083 |
| R-HSA-69481 | G2/M Checkpoints | 8.268772e-01 | 0.083 |
| R-HSA-199991 | Membrane Trafficking | 8.343106e-01 | 0.079 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.412794e-01 | 0.075 |
| R-HSA-9824446 | Viral Infection Pathways | 8.415356e-01 | 0.075 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.507159e-01 | 0.070 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.526711e-01 | 0.069 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.544890e-01 | 0.068 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.562846e-01 | 0.067 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.562846e-01 | 0.067 |
| R-HSA-9664407 | Parasite infection | 8.562846e-01 | 0.067 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.615401e-01 | 0.065 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.682511e-01 | 0.061 |
| R-HSA-69242 | S Phase | 8.714842e-01 | 0.060 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.781076e-01 | 0.056 |
| R-HSA-69306 | DNA Replication | 8.792259e-01 | 0.056 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.821910e-01 | 0.054 |
| R-HSA-9610379 | HCMV Late Events | 8.850836e-01 | 0.053 |
| R-HSA-162587 | HIV Life Cycle | 8.850836e-01 | 0.053 |
| R-HSA-9658195 | Leishmania infection | 8.862106e-01 | 0.052 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.862106e-01 | 0.052 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.873268e-01 | 0.052 |
| R-HSA-877300 | Interferon gamma signaling | 8.879056e-01 | 0.052 |
| R-HSA-5619102 | SLC transporter disorders | 8.985206e-01 | 0.046 |
| R-HSA-611105 | Respiratory electron transport | 9.125965e-01 | 0.040 |
| R-HSA-168255 | Influenza Infection | 9.136778e-01 | 0.039 |
| R-HSA-422475 | Axon guidance | 9.198238e-01 | 0.036 |
| R-HSA-5617833 | Cilium Assembly | 9.247285e-01 | 0.034 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.252486e-01 | 0.034 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.274900e-01 | 0.033 |
| R-HSA-1474244 | Extracellular matrix organization | 9.310899e-01 | 0.031 |
| R-HSA-109582 | Hemostasis | 9.338537e-01 | 0.030 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.339375e-01 | 0.030 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.359870e-01 | 0.029 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.377882e-01 | 0.028 |
| R-HSA-6805567 | Keratinization | 9.391014e-01 | 0.027 |
| R-HSA-9675108 | Nervous system development | 9.408246e-01 | 0.026 |
| R-HSA-397014 | Muscle contraction | 9.434927e-01 | 0.025 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.444741e-01 | 0.025 |
| R-HSA-162906 | HIV Infection | 9.531408e-01 | 0.021 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.586433e-01 | 0.018 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.596641e-01 | 0.018 |
| R-HSA-157118 | Signaling by NOTCH | 9.601650e-01 | 0.018 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.635025e-01 | 0.016 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.656349e-01 | 0.015 |
| R-HSA-392499 | Metabolism of proteins | 9.732350e-01 | 0.012 |
| R-HSA-5668914 | Diseases of metabolism | 9.750173e-01 | 0.011 |
| R-HSA-72766 | Translation | 9.755462e-01 | 0.011 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.755474e-01 | 0.011 |
| R-HSA-5663205 | Infectious disease | 9.813397e-01 | 0.008 |
| R-HSA-8953854 | Metabolism of RNA | 9.815944e-01 | 0.008 |
| R-HSA-8957322 | Metabolism of steroids | 9.860964e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.940192e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.949888e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.988913e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.995003e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998126e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999698e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.871 | 0.603 | 1 | 0.923 |
CLK3 |
0.869 | 0.469 | 1 | 0.840 |
CDK18 |
0.867 | 0.664 | 1 | 0.910 |
CDK1 |
0.865 | 0.640 | 1 | 0.927 |
JNK2 |
0.862 | 0.681 | 1 | 0.930 |
DYRK2 |
0.861 | 0.612 | 1 | 0.902 |
P38G |
0.861 | 0.668 | 1 | 0.904 |
HIPK2 |
0.861 | 0.622 | 1 | 0.894 |
CDK17 |
0.860 | 0.653 | 1 | 0.903 |
JNK3 |
0.859 | 0.667 | 1 | 0.931 |
CDK8 |
0.857 | 0.602 | 1 | 0.921 |
CDK19 |
0.857 | 0.607 | 1 | 0.918 |
DYRK4 |
0.856 | 0.632 | 1 | 0.918 |
P38B |
0.856 | 0.653 | 1 | 0.919 |
CDK3 |
0.855 | 0.571 | 1 | 0.911 |
CDK13 |
0.855 | 0.615 | 1 | 0.926 |
CDK5 |
0.855 | 0.613 | 1 | 0.924 |
SRPK1 |
0.855 | 0.361 | -3 | 0.795 |
CDK16 |
0.854 | 0.636 | 1 | 0.905 |
ERK1 |
0.854 | 0.631 | 1 | 0.916 |
NLK |
0.854 | 0.559 | 1 | 0.857 |
COT |
0.853 | 0.113 | 2 | 0.880 |
CDK7 |
0.853 | 0.596 | 1 | 0.931 |
CLK2 |
0.852 | 0.430 | -3 | 0.770 |
P38D |
0.852 | 0.654 | 1 | 0.908 |
CDK12 |
0.851 | 0.618 | 1 | 0.922 |
HIPK4 |
0.850 | 0.413 | 1 | 0.809 |
HIPK1 |
0.849 | 0.568 | 1 | 0.893 |
P38A |
0.848 | 0.618 | 1 | 0.909 |
CDK14 |
0.847 | 0.625 | 1 | 0.915 |
CDK10 |
0.847 | 0.609 | 1 | 0.914 |
MTOR |
0.847 | 0.222 | 1 | 0.700 |
ERK5 |
0.845 | 0.329 | 1 | 0.789 |
MOS |
0.844 | 0.182 | 1 | 0.678 |
JNK1 |
0.842 | 0.601 | 1 | 0.924 |
SRPK2 |
0.842 | 0.297 | -3 | 0.721 |
CDK9 |
0.842 | 0.580 | 1 | 0.923 |
CDKL1 |
0.841 | 0.223 | -3 | 0.829 |
DYRK1B |
0.841 | 0.566 | 1 | 0.910 |
CDKL5 |
0.840 | 0.235 | -3 | 0.823 |
ICK |
0.840 | 0.356 | -3 | 0.854 |
DYRK1A |
0.839 | 0.505 | 1 | 0.899 |
SRPK3 |
0.839 | 0.280 | -3 | 0.772 |
ERK2 |
0.838 | 0.589 | 1 | 0.907 |
GRK1 |
0.837 | 0.145 | -2 | 0.830 |
PIM3 |
0.836 | 0.063 | -3 | 0.850 |
HIPK3 |
0.836 | 0.532 | 1 | 0.876 |
CDC7 |
0.836 | -0.027 | 1 | 0.657 |
CLK4 |
0.835 | 0.330 | -3 | 0.776 |
PRPK |
0.834 | -0.011 | -1 | 0.811 |
CLK1 |
0.834 | 0.354 | -3 | 0.746 |
CDK2 |
0.834 | 0.438 | 1 | 0.903 |
IKKB |
0.832 | -0.063 | -2 | 0.784 |
MAK |
0.832 | 0.486 | -2 | 0.820 |
NDR2 |
0.830 | 0.031 | -3 | 0.843 |
DYRK3 |
0.830 | 0.446 | 1 | 0.869 |
ATR |
0.828 | -0.007 | 1 | 0.642 |
CDK6 |
0.828 | 0.578 | 1 | 0.907 |
RAF1 |
0.828 | -0.119 | 1 | 0.630 |
DSTYK |
0.827 | -0.076 | 2 | 0.887 |
RSK2 |
0.826 | 0.069 | -3 | 0.790 |
CDK4 |
0.826 | 0.593 | 1 | 0.918 |
CAMK1B |
0.826 | 0.014 | -3 | 0.844 |
BMPR2 |
0.825 | -0.116 | -2 | 0.898 |
PRKD1 |
0.825 | 0.051 | -3 | 0.830 |
TBK1 |
0.824 | -0.127 | 1 | 0.555 |
PRP4 |
0.824 | 0.352 | -3 | 0.762 |
MST4 |
0.824 | 0.017 | 2 | 0.862 |
BMPR1B |
0.824 | 0.076 | 1 | 0.619 |
PKN3 |
0.823 | 0.018 | -3 | 0.824 |
NUAK2 |
0.823 | 0.049 | -3 | 0.825 |
IKKE |
0.823 | -0.119 | 1 | 0.554 |
PIM1 |
0.823 | 0.081 | -3 | 0.794 |
GRK7 |
0.823 | 0.086 | 1 | 0.614 |
CAMK2G |
0.823 | -0.059 | 2 | 0.787 |
P90RSK |
0.823 | 0.062 | -3 | 0.800 |
SKMLCK |
0.821 | 0.012 | -2 | 0.869 |
NEK6 |
0.821 | -0.066 | -2 | 0.870 |
MLK1 |
0.821 | -0.057 | 2 | 0.825 |
GCN2 |
0.821 | -0.190 | 2 | 0.783 |
GRK5 |
0.821 | -0.095 | -3 | 0.840 |
PKN2 |
0.821 | 0.012 | -3 | 0.816 |
PDHK4 |
0.820 | -0.238 | 1 | 0.664 |
NDR1 |
0.820 | -0.013 | -3 | 0.826 |
NIK |
0.820 | -0.031 | -3 | 0.847 |
IKKA |
0.819 | -0.052 | -2 | 0.788 |
GRK6 |
0.819 | -0.031 | 1 | 0.638 |
MAPKAPK2 |
0.818 | 0.057 | -3 | 0.742 |
WNK1 |
0.818 | -0.050 | -2 | 0.904 |
DAPK2 |
0.818 | -0.002 | -3 | 0.851 |
CAMLCK |
0.817 | 0.001 | -2 | 0.843 |
PRKD2 |
0.817 | 0.039 | -3 | 0.766 |
RSK3 |
0.816 | 0.030 | -3 | 0.784 |
GSK3A |
0.816 | 0.214 | 4 | 0.498 |
ULK2 |
0.816 | -0.209 | 2 | 0.761 |
CHAK2 |
0.816 | -0.057 | -1 | 0.742 |
TGFBR2 |
0.816 | -0.084 | -2 | 0.797 |
PKCD |
0.816 | 0.015 | 2 | 0.800 |
RIPK3 |
0.815 | -0.089 | 3 | 0.727 |
CAMK2A |
0.815 | 0.052 | 2 | 0.798 |
P70S6KB |
0.815 | 0.024 | -3 | 0.791 |
CAMK2D |
0.815 | -0.043 | -3 | 0.815 |
DLK |
0.815 | -0.088 | 1 | 0.619 |
MLK3 |
0.814 | -0.003 | 2 | 0.766 |
MOK |
0.814 | 0.417 | 1 | 0.824 |
NEK7 |
0.814 | -0.180 | -3 | 0.817 |
MAPKAPK3 |
0.814 | -0.001 | -3 | 0.768 |
RSK4 |
0.813 | 0.072 | -3 | 0.776 |
LATS1 |
0.813 | 0.059 | -3 | 0.855 |
CAMK2B |
0.813 | 0.010 | 2 | 0.757 |
TGFBR1 |
0.812 | 0.011 | -2 | 0.826 |
PDHK1 |
0.812 | -0.250 | 1 | 0.643 |
MLK2 |
0.812 | -0.074 | 2 | 0.815 |
LATS2 |
0.811 | -0.033 | -5 | 0.715 |
ATM |
0.811 | -0.047 | 1 | 0.597 |
MARK4 |
0.811 | -0.075 | 4 | 0.778 |
PKCB |
0.810 | 0.022 | 2 | 0.770 |
ALK4 |
0.810 | -0.028 | -2 | 0.848 |
MASTL |
0.810 | -0.179 | -2 | 0.846 |
HUNK |
0.810 | -0.159 | 2 | 0.803 |
PKCG |
0.809 | 0.011 | 2 | 0.763 |
AMPKA1 |
0.809 | -0.065 | -3 | 0.827 |
GRK4 |
0.808 | -0.122 | -2 | 0.846 |
YSK4 |
0.808 | -0.082 | 1 | 0.571 |
AURC |
0.808 | 0.009 | -2 | 0.621 |
PKCA |
0.808 | 0.025 | 2 | 0.748 |
DNAPK |
0.808 | -0.007 | 1 | 0.573 |
ACVR2B |
0.808 | 0.002 | -2 | 0.803 |
BCKDK |
0.808 | -0.176 | -1 | 0.714 |
PKACG |
0.808 | -0.029 | -2 | 0.711 |
MSK2 |
0.807 | 0.006 | -3 | 0.776 |
CK1E |
0.807 | 0.079 | -3 | 0.607 |
ANKRD3 |
0.807 | -0.145 | 1 | 0.623 |
ERK7 |
0.806 | 0.197 | 2 | 0.546 |
PASK |
0.806 | 0.100 | -3 | 0.870 |
IRE1 |
0.806 | -0.088 | 1 | 0.545 |
NEK9 |
0.806 | -0.196 | 2 | 0.823 |
ACVR2A |
0.806 | -0.029 | -2 | 0.789 |
TSSK2 |
0.805 | -0.065 | -5 | 0.831 |
ULK1 |
0.805 | -0.221 | -3 | 0.771 |
AKT2 |
0.805 | 0.077 | -3 | 0.711 |
VRK2 |
0.805 | -0.001 | 1 | 0.682 |
MLK4 |
0.805 | -0.056 | 2 | 0.729 |
PKACB |
0.804 | 0.038 | -2 | 0.633 |
PKR |
0.804 | -0.073 | 1 | 0.602 |
MSK1 |
0.804 | 0.027 | -3 | 0.770 |
FAM20C |
0.804 | -0.028 | 2 | 0.547 |
AMPKA2 |
0.804 | -0.044 | -3 | 0.803 |
PRKD3 |
0.803 | 0.021 | -3 | 0.752 |
ALK2 |
0.803 | -0.020 | -2 | 0.828 |
TTBK2 |
0.803 | -0.181 | 2 | 0.672 |
PLK1 |
0.803 | -0.114 | -2 | 0.805 |
MST3 |
0.803 | 0.038 | 2 | 0.858 |
MEK1 |
0.802 | -0.116 | 2 | 0.834 |
DRAK1 |
0.802 | -0.049 | 1 | 0.566 |
GSK3B |
0.802 | 0.085 | 4 | 0.494 |
BMPR1A |
0.801 | 0.023 | 1 | 0.603 |
GRK2 |
0.801 | -0.033 | -2 | 0.739 |
RIPK1 |
0.801 | -0.199 | 1 | 0.563 |
TSSK1 |
0.800 | -0.064 | -3 | 0.844 |
PAK1 |
0.800 | -0.060 | -2 | 0.775 |
PHKG1 |
0.800 | -0.054 | -3 | 0.806 |
SGK3 |
0.800 | 0.017 | -3 | 0.767 |
WNK3 |
0.799 | -0.275 | 1 | 0.585 |
PIM2 |
0.799 | 0.052 | -3 | 0.755 |
SMG1 |
0.799 | -0.081 | 1 | 0.598 |
PRKX |
0.799 | 0.055 | -3 | 0.695 |
CK1D |
0.799 | 0.085 | -3 | 0.559 |
NIM1 |
0.799 | -0.109 | 3 | 0.752 |
MEKK3 |
0.799 | -0.065 | 1 | 0.596 |
TAO3 |
0.799 | 0.002 | 1 | 0.606 |
TLK2 |
0.799 | -0.111 | 1 | 0.585 |
PKCZ |
0.799 | -0.056 | 2 | 0.779 |
PKCH |
0.798 | -0.039 | 2 | 0.741 |
MPSK1 |
0.798 | 0.075 | 1 | 0.582 |
IRE2 |
0.798 | -0.092 | 2 | 0.740 |
MNK2 |
0.797 | -0.065 | -2 | 0.780 |
MYLK4 |
0.797 | -0.011 | -2 | 0.749 |
CAMK4 |
0.797 | -0.131 | -3 | 0.789 |
NUAK1 |
0.796 | -0.048 | -3 | 0.773 |
QSK |
0.796 | -0.051 | 4 | 0.754 |
MNK1 |
0.796 | -0.048 | -2 | 0.784 |
PAK3 |
0.795 | -0.105 | -2 | 0.771 |
MEKK2 |
0.795 | -0.078 | 2 | 0.797 |
MEK5 |
0.794 | -0.139 | 2 | 0.815 |
PKG2 |
0.794 | -0.016 | -2 | 0.631 |
QIK |
0.794 | -0.126 | -3 | 0.804 |
PINK1 |
0.794 | 0.010 | 1 | 0.711 |
MELK |
0.794 | -0.087 | -3 | 0.783 |
ZAK |
0.794 | -0.131 | 1 | 0.567 |
CK2A2 |
0.793 | 0.026 | 1 | 0.545 |
DCAMKL1 |
0.793 | -0.022 | -3 | 0.771 |
NEK2 |
0.793 | -0.174 | 2 | 0.802 |
AURA |
0.793 | -0.028 | -2 | 0.592 |
CK1A2 |
0.793 | 0.064 | -3 | 0.559 |
MEKK1 |
0.792 | -0.143 | 1 | 0.595 |
GAK |
0.792 | 0.039 | 1 | 0.632 |
PLK3 |
0.792 | -0.140 | 2 | 0.748 |
AURB |
0.792 | -0.038 | -2 | 0.617 |
MARK3 |
0.792 | -0.059 | 4 | 0.704 |
CHAK1 |
0.791 | -0.181 | 2 | 0.739 |
BRSK1 |
0.791 | -0.064 | -3 | 0.781 |
CK1G1 |
0.791 | 0.004 | -3 | 0.605 |
BRAF |
0.791 | -0.147 | -4 | 0.789 |
SIK |
0.791 | -0.054 | -3 | 0.749 |
GCK |
0.791 | 0.012 | 1 | 0.616 |
GRK3 |
0.791 | -0.022 | -2 | 0.696 |
PAK6 |
0.790 | -0.046 | -2 | 0.685 |
CAMK1G |
0.790 | -0.023 | -3 | 0.758 |
MAPKAPK5 |
0.789 | -0.070 | -3 | 0.732 |
CHK1 |
0.789 | -0.091 | -3 | 0.786 |
NEK5 |
0.788 | -0.146 | 1 | 0.586 |
PLK4 |
0.788 | -0.139 | 2 | 0.597 |
AKT1 |
0.788 | 0.029 | -3 | 0.720 |
PAK2 |
0.788 | -0.115 | -2 | 0.760 |
NEK11 |
0.788 | -0.097 | 1 | 0.605 |
SMMLCK |
0.787 | -0.026 | -3 | 0.813 |
TLK1 |
0.786 | -0.146 | -2 | 0.841 |
CK2A1 |
0.786 | 0.027 | 1 | 0.526 |
PKCT |
0.786 | -0.041 | 2 | 0.745 |
HPK1 |
0.786 | 0.009 | 1 | 0.607 |
MST2 |
0.786 | -0.058 | 1 | 0.613 |
BRSK2 |
0.785 | -0.122 | -3 | 0.782 |
TAO2 |
0.785 | -0.055 | 2 | 0.844 |
MARK2 |
0.785 | -0.095 | 4 | 0.662 |
PDK1 |
0.785 | -0.046 | 1 | 0.594 |
PERK |
0.785 | -0.202 | -2 | 0.841 |
EEF2K |
0.785 | -0.016 | 3 | 0.849 |
PKCE |
0.785 | 0.026 | 2 | 0.748 |
WNK4 |
0.785 | -0.144 | -2 | 0.901 |
HRI |
0.784 | -0.217 | -2 | 0.851 |
TNIK |
0.784 | -0.003 | 3 | 0.873 |
P70S6K |
0.784 | -0.012 | -3 | 0.718 |
DAPK3 |
0.783 | -0.002 | -3 | 0.796 |
TAK1 |
0.783 | -0.054 | 1 | 0.606 |
PKACA |
0.782 | 0.008 | -2 | 0.574 |
MINK |
0.782 | -0.055 | 1 | 0.580 |
SGK1 |
0.781 | 0.071 | -3 | 0.650 |
PKCI |
0.781 | -0.042 | 2 | 0.756 |
IRAK4 |
0.781 | -0.164 | 1 | 0.537 |
HGK |
0.781 | -0.046 | 3 | 0.871 |
MEKK6 |
0.781 | -0.086 | 1 | 0.587 |
LKB1 |
0.781 | -0.093 | -3 | 0.792 |
KHS2 |
0.781 | 0.039 | 1 | 0.608 |
SSTK |
0.781 | -0.070 | 4 | 0.749 |
DAPK1 |
0.781 | 0.010 | -3 | 0.789 |
MAP3K15 |
0.781 | -0.076 | 1 | 0.563 |
NEK8 |
0.780 | -0.168 | 2 | 0.808 |
AKT3 |
0.780 | 0.058 | -3 | 0.667 |
MARK1 |
0.780 | -0.119 | 4 | 0.721 |
KHS1 |
0.780 | 0.009 | 1 | 0.591 |
PHKG2 |
0.780 | -0.082 | -3 | 0.763 |
DCAMKL2 |
0.780 | -0.075 | -3 | 0.782 |
SBK |
0.779 | 0.131 | -3 | 0.599 |
CAMKK1 |
0.779 | -0.196 | -2 | 0.789 |
SNRK |
0.779 | -0.200 | 2 | 0.638 |
LRRK2 |
0.778 | -0.061 | 2 | 0.827 |
CAMKK2 |
0.777 | -0.168 | -2 | 0.785 |
PKN1 |
0.775 | -0.011 | -3 | 0.723 |
VRK1 |
0.774 | -0.118 | 2 | 0.833 |
CAMK1D |
0.773 | -0.027 | -3 | 0.684 |
MST1 |
0.773 | -0.106 | 1 | 0.585 |
PLK2 |
0.773 | -0.072 | -3 | 0.751 |
NEK4 |
0.773 | -0.178 | 1 | 0.564 |
CHK2 |
0.773 | 0.020 | -3 | 0.651 |
TTBK1 |
0.772 | -0.205 | 2 | 0.591 |
ROCK2 |
0.772 | 0.004 | -3 | 0.783 |
PDHK3_TYR |
0.772 | 0.218 | 4 | 0.858 |
BUB1 |
0.771 | 0.017 | -5 | 0.770 |
MRCKB |
0.771 | 0.004 | -3 | 0.735 |
PAK5 |
0.770 | -0.077 | -2 | 0.629 |
LOK |
0.770 | -0.105 | -2 | 0.777 |
SLK |
0.770 | -0.088 | -2 | 0.738 |
NEK1 |
0.770 | -0.162 | 1 | 0.555 |
OSR1 |
0.770 | -0.029 | 2 | 0.797 |
HASPIN |
0.769 | 0.010 | -1 | 0.633 |
PBK |
0.768 | -0.053 | 1 | 0.570 |
PAK4 |
0.768 | -0.063 | -2 | 0.634 |
YSK1 |
0.768 | -0.100 | 2 | 0.806 |
MRCKA |
0.767 | -0.022 | -3 | 0.745 |
BMPR2_TYR |
0.767 | 0.201 | -1 | 0.870 |
PDHK4_TYR |
0.767 | 0.175 | 2 | 0.864 |
DMPK1 |
0.767 | 0.039 | -3 | 0.751 |
IRAK1 |
0.765 | -0.298 | -1 | 0.670 |
ALPHAK3 |
0.765 | -0.009 | -1 | 0.757 |
MAP2K6_TYR |
0.764 | 0.143 | -1 | 0.832 |
MAP2K4_TYR |
0.764 | 0.090 | -1 | 0.823 |
CK1A |
0.762 | 0.032 | -3 | 0.479 |
CAMK1A |
0.762 | -0.012 | -3 | 0.669 |
PDHK1_TYR |
0.762 | 0.102 | -1 | 0.845 |
STK33 |
0.761 | -0.168 | 2 | 0.588 |
TESK1_TYR |
0.761 | 0.040 | 3 | 0.876 |
TTK |
0.760 | -0.079 | -2 | 0.824 |
YANK3 |
0.760 | -0.041 | 2 | 0.376 |
PKMYT1_TYR |
0.760 | 0.095 | 3 | 0.835 |
MEK2 |
0.758 | -0.276 | 2 | 0.791 |
MAP2K7_TYR |
0.757 | -0.047 | 2 | 0.834 |
ASK1 |
0.757 | -0.125 | 1 | 0.557 |
CRIK |
0.757 | 0.029 | -3 | 0.728 |
MYO3B |
0.757 | -0.072 | 2 | 0.817 |
ROCK1 |
0.756 | -0.016 | -3 | 0.744 |
LIMK2_TYR |
0.756 | 0.070 | -3 | 0.848 |
BIKE |
0.756 | -0.039 | 1 | 0.547 |
RIPK2 |
0.756 | -0.264 | 1 | 0.537 |
MYO3A |
0.756 | -0.071 | 1 | 0.572 |
EPHA6 |
0.755 | 0.069 | -1 | 0.829 |
PINK1_TYR |
0.753 | -0.076 | 1 | 0.635 |
TAO1 |
0.753 | -0.099 | 1 | 0.538 |
NEK3 |
0.752 | -0.185 | 1 | 0.544 |
TXK |
0.752 | 0.054 | 1 | 0.624 |
EPHB4 |
0.750 | -0.014 | -1 | 0.781 |
RET |
0.746 | -0.130 | 1 | 0.596 |
AAK1 |
0.746 | 0.006 | 1 | 0.483 |
BLK |
0.745 | 0.061 | -1 | 0.814 |
LIMK1_TYR |
0.745 | -0.100 | 2 | 0.823 |
ABL2 |
0.745 | -0.049 | -1 | 0.755 |
LCK |
0.745 | 0.047 | -1 | 0.818 |
PKG1 |
0.744 | -0.066 | -2 | 0.534 |
MST1R |
0.744 | -0.093 | 3 | 0.793 |
CSF1R |
0.744 | -0.065 | 3 | 0.763 |
JAK3 |
0.744 | -0.032 | 1 | 0.578 |
STLK3 |
0.743 | -0.170 | 1 | 0.546 |
EPHA4 |
0.742 | -0.015 | 2 | 0.754 |
FGR |
0.742 | -0.092 | 1 | 0.616 |
ITK |
0.742 | -0.031 | -1 | 0.757 |
ROS1 |
0.742 | -0.124 | 3 | 0.745 |
BMX |
0.741 | -0.003 | -1 | 0.715 |
FYN |
0.740 | 0.069 | -1 | 0.825 |
ABL1 |
0.740 | -0.071 | -1 | 0.741 |
JAK2 |
0.740 | -0.136 | 1 | 0.600 |
HCK |
0.740 | -0.039 | -1 | 0.801 |
YES1 |
0.740 | -0.083 | -1 | 0.780 |
SRMS |
0.740 | -0.087 | 1 | 0.638 |
TYK2 |
0.739 | -0.216 | 1 | 0.590 |
TYRO3 |
0.739 | -0.169 | 3 | 0.774 |
FER |
0.738 | -0.152 | 1 | 0.655 |
INSRR |
0.737 | -0.093 | 3 | 0.721 |
KIT |
0.737 | -0.074 | 3 | 0.763 |
EPHB1 |
0.737 | -0.094 | 1 | 0.639 |
KDR |
0.737 | -0.044 | 3 | 0.730 |
MET |
0.736 | -0.030 | 3 | 0.760 |
FGFR2 |
0.736 | -0.067 | 3 | 0.778 |
JAK1 |
0.736 | -0.072 | 1 | 0.554 |
CK1G3 |
0.735 | 0.003 | -3 | 0.437 |
EPHB2 |
0.735 | -0.070 | -1 | 0.767 |
EPHB3 |
0.734 | -0.090 | -1 | 0.762 |
FLT1 |
0.734 | -0.022 | -1 | 0.818 |
TNK2 |
0.734 | -0.103 | 3 | 0.727 |
SYK |
0.734 | 0.096 | -1 | 0.824 |
DDR1 |
0.733 | -0.194 | 4 | 0.767 |
NEK10_TYR |
0.732 | -0.137 | 1 | 0.501 |
PTK2 |
0.732 | 0.105 | -1 | 0.834 |
TNNI3K_TYR |
0.732 | -0.074 | 1 | 0.601 |
TEK |
0.730 | -0.068 | 3 | 0.698 |
EPHA7 |
0.729 | -0.062 | 2 | 0.748 |
CK1G2 |
0.729 | 0.041 | -3 | 0.524 |
TEC |
0.729 | -0.123 | -1 | 0.672 |
WEE1_TYR |
0.729 | -0.077 | -1 | 0.706 |
MERTK |
0.729 | -0.136 | 3 | 0.750 |
FGFR1 |
0.728 | -0.116 | 3 | 0.737 |
YANK2 |
0.728 | -0.063 | 2 | 0.390 |
FRK |
0.728 | -0.067 | -1 | 0.793 |
FGFR3 |
0.727 | -0.061 | 3 | 0.747 |
ERBB2 |
0.725 | -0.123 | 1 | 0.571 |
EPHA3 |
0.725 | -0.109 | 2 | 0.716 |
TNK1 |
0.725 | -0.152 | 3 | 0.751 |
FLT3 |
0.725 | -0.193 | 3 | 0.771 |
EPHA8 |
0.724 | -0.031 | -1 | 0.791 |
EGFR |
0.724 | -0.061 | 1 | 0.506 |
SRC |
0.724 | -0.051 | -1 | 0.789 |
LYN |
0.724 | -0.079 | 3 | 0.677 |
PDGFRB |
0.723 | -0.254 | 3 | 0.778 |
AXL |
0.723 | -0.204 | 3 | 0.750 |
BTK |
0.722 | -0.217 | -1 | 0.699 |
EPHA5 |
0.722 | -0.079 | 2 | 0.733 |
MATK |
0.721 | -0.093 | -1 | 0.700 |
EPHA1 |
0.720 | -0.135 | 3 | 0.744 |
NTRK1 |
0.720 | -0.228 | -1 | 0.763 |
ZAP70 |
0.720 | 0.066 | -1 | 0.758 |
NTRK3 |
0.719 | -0.148 | -1 | 0.730 |
PTK2B |
0.719 | -0.111 | -1 | 0.695 |
FGFR4 |
0.719 | -0.079 | -1 | 0.740 |
ALK |
0.719 | -0.199 | 3 | 0.681 |
PTK6 |
0.719 | -0.243 | -1 | 0.674 |
FLT4 |
0.718 | -0.160 | 3 | 0.722 |
EPHA2 |
0.717 | -0.029 | -1 | 0.772 |
ERBB4 |
0.717 | -0.002 | 1 | 0.543 |
DDR2 |
0.717 | -0.083 | 3 | 0.707 |
LTK |
0.717 | -0.204 | 3 | 0.706 |
PDGFRA |
0.717 | -0.277 | 3 | 0.773 |
INSR |
0.716 | -0.180 | 3 | 0.699 |
CSK |
0.714 | -0.146 | 2 | 0.746 |
NTRK2 |
0.713 | -0.261 | 3 | 0.724 |
MUSK |
0.707 | -0.138 | 1 | 0.490 |
IGF1R |
0.704 | -0.144 | 3 | 0.630 |
FES |
0.696 | -0.133 | -1 | 0.683 |