Motif 14 (n=201)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NHR9 | SMCHD1 | S1974 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| B2RTY4 | MYO9A | S1230 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| E7ETH6 | ZNF587B | S205 | ochoa | Zinc finger protein 587B | May be involved in transcriptional regulation. {ECO:0000305}. |
| O14974 | PPP1R12A | S299 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O43242 | PSMD3 | S430 | ochoa | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O43464 | HTRA2 | S400 | psp | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O75179 | ANKRD17 | S1709 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75376 | NCOR1 | S1111 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75969 | AKAP3 | S208 | ochoa | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}. |
| O94913 | PCF11 | S370 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94913 | PCF11 | S372 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95197 | RTN3 | S246 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95359 | TACC2 | S97 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S2134 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P02679 | FGG | S404 | ochoa | Fibrinogen gamma chain | Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P07197 | NEFM | S685 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P10275 | AR | S651 | ochoa|psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P15056 | BRAF | S419 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P17036 | ZNF3 | S143 | ochoa | Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) | Involved in cell differentiation and/or proliferation. |
| P20929 | NEB | S2182 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P21817 | RYR1 | S2000 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P22607 | FGFR3 | S408 | ochoa | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
| P27816 | MAP4 | S696 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28290 | ITPRID2 | S316 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29401 | TKT | S348 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30304 | CDC25A | S283 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P35251 | RFC1 | S360 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35749 | MYH11 | S23 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P41252 | IARS1 | S1047 | ochoa | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P46782 | RPS5 | S52 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P46821 | MAP1B | S2271 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48651 | PTDSS1 | S442 | ochoa | Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}. |
| P48739 | PITPNB | S184 | ochoa | Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109). {ECO:0000250|UniProtKB:Q9TR36, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:20332109}. |
| P49321 | NASP | S726 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49591 | SARS1 | S331 | ochoa | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| P51398 | DAP3 | S280 | ochoa|psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P51587 | BRCA2 | S3319 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52294 | KPNA1 | S95 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P52948 | NUP98 | S1192 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54198 | HIRA | S687 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| Q00536 | CDK16 | S138 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00537 | CDK17 | S165 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q01484 | ANK2 | S1846 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1858 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1882 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1905 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1917 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1929 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1940 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1964 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1976 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q03188 | CENPC | S133 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08AE8 | SPIRE1 | S507 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q09666 | AHNAK | S5077 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12830 | BPTF | S1231 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12931 | TRAP1 | S511 | psp | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13129 | RLF | S632 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13177 | PAK2 | S152 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13352 | ITGB3BP | S33 | ochoa|psp | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) | Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}. |
| Q13415 | ORC1 | S287 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13501 | SQSTM1 | S170 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13637 | RAB32 | S154 | ochoa | Ras-related protein Rab-32 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}. |
| Q14008 | CKAP5 | S816 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14324 | MYBPC2 | S487 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14677 | CLINT1 | S227 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14721 | KCNB1 | S737 | ochoa | Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:10484328, PubMed:12560340, PubMed:1283219, PubMed:19074135, PubMed:19717558, PubMed:24901643, PubMed:8081723). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. |
| Q14865 | ARID5B | S566 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q15326 | ZMYND11 | S447 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15468 | STIL | S1225 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15596 | NCOA2 | S736 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15648 | MED1 | S1401 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15652 | JMJD1C | S617 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16236 | NFE2L2 | S433 | ochoa|psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
| Q16665 | HIF1A | S687 | ochoa|psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q2M1K9 | ZNF423 | S1160 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q3B820 | FAM161A | S462 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
| Q4KMZ1 | IQCC | S196 | ochoa | IQ domain-containing protein C | None |
| Q4KMZ1 | IQCC | S257 | ochoa | IQ domain-containing protein C | None |
| Q4LE39 | ARID4B | S778 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4VC44 | FLYWCH1 | S696 | ochoa | FLYWCH-type zinc finger-containing protein 1 | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}. |
| Q52LD8 | RFTN2 | S430 | ochoa | Raftlin-2 (Raft-linking protein 2) | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}. |
| Q5JST6 | EFHC2 | S382 | ochoa | EF-hand domain-containing family member C2 | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}. |
| Q5JSZ5 | PRRC2B | S556 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T3J3 | LRIF1 | S451 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5TAX3 | TUT4 | S841 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5TB30 | DEPDC1 | S110 | ochoa|psp | DEP domain-containing protein 1A | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
| Q5THK1 | PRR14L | S437 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5THK1 | PRR14L | S717 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5UIP0 | RIF1 | S1454 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S105 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT06 | CEP350 | S2830 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q659A1 | ICE2 | S326 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q68DK7 | MSL1 | S362 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6AI39 | BICRAL | S980 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6JBY9 | RCSD1 | S351 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6KC79 | NIPBL | S912 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6KC79 | NIPBL | S2568 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P4E1 | GOLM2 | S319 | ochoa | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | None |
| Q6PH81 | C16orf87 | S50 | ochoa | UPF0547 protein C16orf87 | None |
| Q6ZU35 | CRACD | S53 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZV73 | FGD6 | S62 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q70EL4 | USP43 | S969 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q711Q0 | CEFIP | S844 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q7Z3E2 | CCDC186 | S139 | ochoa | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | None |
| Q7Z3T8 | ZFYVE16 | S939 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z4S6 | KIF21A | S1239 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6J2 | TAMALIN | S94 | ochoa | Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) | Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}. |
| Q86SQ7 | SDCCAG8 | S92 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
| Q86U42 | PABPN1 | S150 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q86UE4 | MTDH | S308 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UX7 | FERMT3 | S428 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86W50 | METTL16 | S329 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IVF2 | AHNAK2 | S1112 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S3408 | ochoa | Protein AHNAK2 | None |
| Q8IWZ3 | ANKHD1 | S1670 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IWZ3 | ANKHD1 | S1679 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IY81 | FTSJ3 | S584 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8IYB3 | SRRM1 | S431 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S452 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYP9 | ZDHHC23 | S252 | ochoa | Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}. |
| Q8IZT6 | ASPM | S605 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8NAP3 | ZBTB38 | S1151 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NB50 | ZFP62 | S97 | ochoa | Zinc finger protein 62 homolog (Zfp-62) | May play a role in differentiating skeletal muscle. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S2828 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TBB5 | KLHDC4 | S114 | ochoa | Kelch domain-containing protein 4 | None |
| Q8TCN5 | ZNF507 | S388 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TCN5 | ZNF507 | S887 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8WWQ0 | PHIP | S911 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXG6 | MADD | S930 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WYL5 | SSH1 | S576 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WYP5 | AHCTF1 | S2212 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92598 | HSPH1 | S557 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92615 | LARP4B | S664 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92750 | TAF4B | S595 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q96BY6 | DOCK10 | S877 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96C24 | SYTL4 | S509 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96C92 | ENTR1 | S86 | ochoa | Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3) | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}. |
| Q96DG6 | CMBL | S223 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q96EV2 | RBM33 | S765 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96JM2 | ZNF462 | S1747 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96RV3 | PCNX1 | S420 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96S38 | RPS6KC1 | S423 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96T23 | RSF1 | S570 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T23 | RSF1 | S748 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99700 | ATXN2 | S772 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99707 | MTR | S156 | ochoa | Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:17288554, PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510). {ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17288554, ECO:0000269|PubMed:27771510}. |
| Q9BTC0 | DIDO1 | S523 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTL3 | RAMAC | S36 | ochoa|psp | RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM) | Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). {ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871}. |
| Q9BVV6 | KIAA0586 | S1067 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BVV6 | KIAA0586 | S1151 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BVW5 | TIPIN | S222 | ochoa | TIMELESS-interacting protein | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}. |
| Q9BXF6 | RAB11FIP5 | S188 | ochoa|psp | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY12 | SCAPER | S86 | ochoa | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}. |
| Q9BY84 | DUSP16 | S446 | ochoa|psp | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
| Q9BY89 | KIAA1671 | S1366 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C040 | TRIM2 | S440 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
| Q9C0H5 | ARHGAP39 | S115 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H2X9 | SLC12A5 | S1045 | ochoa | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) | Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:12106695, ECO:0000269|PubMed:24668262}. |
| Q9H3Q1 | CDC42EP4 | S142 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4D5 | NXF3 | S283 | ochoa | Nuclear RNA export factor 3 (TAP-like protein 3) (TAPL-3) | May function as a tissue-specific nuclear mRNA export factor. |
| Q9H792 | PEAK1 | S1036 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HCI7 | MSL2 | S211 | ochoa | E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.27) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:21726816, PubMed:30930284). This activity is greatly enhanced by heterodimerization with MSL1 (PubMed:21726816, PubMed:30930284). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1 (PubMed:19033443, PubMed:23874665). {ECO:0000250|UniProtKB:Q69ZF8, ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:19033443, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:23874665, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q9HCS5 | EPB41L4A | S389 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NQ66 | PLCB1 | S982 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9NQQ7 | SLC35C2 | S336 | ochoa | Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein) | May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}. |
| Q9NQU5 | PAK6 | S616 | ochoa | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NQV5 | PRDM11 | S63 | ochoa | PR domain-containing protein 11 (EC 2.1.1.-) | May be involved in transcription regulation. {ECO:0000269|PubMed:25499759}. |
| Q9NR48 | ASH1L | S1630 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NS91 | RAD18 | S158 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NUA8 | ZBTB40 | S728 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NX40 | OCIAD1 | S108 | ochoa | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}. |
| Q9NY59 | SMPD3 | S173 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYF8 | BCLAF1 | S496 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S884 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZ53 | PODXL2 | S144 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9NZJ5 | EIF2AK3 | S879 | psp | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}. |
| Q9P0K7 | RAI14 | S512 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P1Y6 | PHRF1 | S867 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P2E9 | RRBP1 | S573 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2E9 | RRBP1 | S583 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2R6 | RERE | S642 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UHB7 | AFF4 | S814 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHF7 | TRPS1 | S830 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UIG0 | BAZ1B | S349 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJV8 | PURG | S156 | ochoa | Purine-rich element-binding protein gamma (Purine-rich element-binding protein G) | None |
| Q9UKV3 | ACIN1 | S388 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULM3 | YEATS2 | S536 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UMS6 | SYNPO2 | S705 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UN81 | L1RE1 | S27 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9Y253 | POLH | S687 | psp | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
| Q9Y2D9 | ZNF652 | S57 | ochoa | Zinc finger protein 652 | Functions as a transcriptional repressor. {ECO:0000269|PubMed:16966434}. |
| Q9Y3E1 | HDGFL3 | S162 | ochoa | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}. |
| Q9Y3R0 | GRIP1 | S996 | ochoa | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| Q9Y478 | PRKAB1 | S40 | ochoa | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y4G2 | PLEKHM1 | S435 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y5K3 | PCYT1B | S233 | ochoa | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q9Y5Z4 | HEBP2 | S181 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| Q9Y6U3 | SCIN | S381 | ochoa | Scinderin (Adseverin) | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9, ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009, ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}. |
| P14625 | HSP90B1 | S552 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| Q02156 | PRKCE | S62 | Sugiyama | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q86UR5 | RIMS1 | S288 | SIGNOR | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.000980 | 3.009 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.001400 | 2.854 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.001400 | 2.854 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.002531 | 2.597 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.001827 | 2.738 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.001554 | 2.809 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.001246 | 2.905 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000333 | 3.478 |
| R-HSA-1640170 | Cell Cycle | 0.002511 | 2.600 |
| R-HSA-4839726 | Chromatin organization | 0.002494 | 2.603 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.003448 | 2.462 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.003200 | 2.495 |
| R-HSA-2262752 | Cellular responses to stress | 0.003380 | 2.471 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.003558 | 2.449 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.005490 | 2.260 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.006001 | 2.222 |
| R-HSA-73893 | DNA Damage Bypass | 0.006281 | 2.202 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.006558 | 2.183 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.007302 | 2.137 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.007302 | 2.137 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.025020 | 1.602 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.025020 | 1.602 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.025020 | 1.602 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.017901 | 1.747 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.022287 | 1.652 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.022287 | 1.652 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.008837 | 2.054 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.011161 | 1.952 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.012007 | 1.921 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.012007 | 1.921 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.013806 | 1.860 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.013806 | 1.860 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.014760 | 1.831 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.016778 | 1.775 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.021253 | 1.673 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.022464 | 1.649 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.030506 | 1.516 |
| R-HSA-774815 | Nucleosome assembly | 0.030506 | 1.516 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.020313 | 1.692 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.028399 | 1.547 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.023712 | 1.625 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.010351 | 1.985 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.030506 | 1.516 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.021253 | 1.673 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.024629 | 1.609 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.029598 | 1.529 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.014143 | 1.849 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.011161 | 1.952 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.030506 | 1.516 |
| R-HSA-9707616 | Heme signaling | 0.012596 | 1.900 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.014760 | 1.831 |
| R-HSA-5693538 | Homology Directed Repair | 0.027298 | 1.564 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.020043 | 1.698 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.029455 | 1.531 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.009576 | 2.019 |
| R-HSA-3371556 | Cellular response to heat stress | 0.029650 | 1.528 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.029650 | 1.528 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.015751 | 1.803 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.015158 | 1.819 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.026406 | 1.578 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.013208 | 1.879 |
| R-HSA-428540 | Activation of RAC1 | 0.015863 | 1.800 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.022464 | 1.649 |
| R-HSA-73894 | DNA Repair | 0.024041 | 1.619 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.015863 | 1.800 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.020079 | 1.697 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.019706 | 1.705 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.024629 | 1.609 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.008763 | 2.057 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.017841 | 1.749 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.020043 | 1.698 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.029400 | 1.532 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.021968 | 1.658 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.031288 | 1.505 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.031974 | 1.495 |
| R-HSA-75153 | Apoptotic execution phase | 0.031974 | 1.495 |
| R-HSA-1483196 | PI and PC transport between ER and Golgi membranes | 0.037296 | 1.428 |
| R-HSA-2033515 | t(4;14) translocations of FGFR3 | 0.037296 | 1.428 |
| R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 0.037296 | 1.428 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.037722 | 1.423 |
| R-HSA-72187 | mRNA 3'-end processing | 0.041547 | 1.381 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.037722 | 1.423 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 0.037296 | 1.428 |
| R-HSA-69206 | G1/S Transition | 0.033848 | 1.470 |
| R-HSA-68886 | M Phase | 0.033887 | 1.470 |
| R-HSA-168255 | Influenza Infection | 0.041545 | 1.381 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.040599 | 1.391 |
| R-HSA-162906 | HIV Infection | 0.039181 | 1.407 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.034928 | 1.457 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.043556 | 1.361 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.043556 | 1.361 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.046590 | 1.332 |
| R-HSA-69275 | G2/M Transition | 0.047692 | 1.322 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.049417 | 1.306 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.056135 | 1.251 |
| R-HSA-429947 | Deadenylation of mRNA | 0.056135 | 1.251 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.054321 | 1.265 |
| R-HSA-191859 | snRNP Assembly | 0.054321 | 1.265 |
| R-HSA-68877 | Mitotic Prometaphase | 0.054374 | 1.265 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.056135 | 1.251 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.049546 | 1.305 |
| R-HSA-3214847 | HATs acetylate histones | 0.052381 | 1.281 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.050499 | 1.297 |
| R-HSA-75893 | TNF signaling | 0.048639 | 1.313 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.058278 | 1.234 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.058278 | 1.234 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.058971 | 1.229 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.060306 | 1.220 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.061387 | 1.212 |
| R-HSA-69242 | S Phase | 0.061442 | 1.212 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.073207 | 1.135 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.073379 | 1.134 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.070933 | 1.149 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.062843 | 1.202 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.069201 | 1.160 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.073207 | 1.135 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.068744 | 1.163 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.073207 | 1.135 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.074109 | 1.130 |
| R-HSA-162587 | HIV Life Cycle | 0.073276 | 1.135 |
| R-HSA-73887 | Death Receptor Signaling | 0.069201 | 1.160 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.066294 | 1.179 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.084878 | 1.071 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.084878 | 1.071 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.096404 | 1.016 |
| R-HSA-3359467 | Defective MTRR causes HMAE | 0.096404 | 1.016 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.096404 | 1.016 |
| R-HSA-3359469 | Defective MTR causes HMAG | 0.107785 | 0.967 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.107785 | 0.967 |
| R-HSA-190371 | FGFR3b ligand binding and activation | 0.119023 | 0.924 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.119023 | 0.924 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.130120 | 0.886 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.130120 | 0.886 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.141079 | 0.851 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.141079 | 0.851 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.173136 | 0.762 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.183555 | 0.736 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.193843 | 0.713 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.193843 | 0.713 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.080695 | 1.093 |
| R-HSA-390522 | Striated Muscle Contraction | 0.092067 | 1.036 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.223941 | 0.650 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.223941 | 0.650 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.233723 | 0.631 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.107893 | 0.967 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.107893 | 0.967 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.243382 | 0.614 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.252920 | 0.597 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.252920 | 0.597 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.252920 | 0.597 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.124377 | 0.905 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.262338 | 0.581 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.271638 | 0.566 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.271638 | 0.566 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.271638 | 0.566 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.271638 | 0.566 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.280822 | 0.552 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.150112 | 0.824 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.150112 | 0.824 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.150112 | 0.824 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.289890 | 0.538 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.289890 | 0.538 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.096988 | 1.013 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.176785 | 0.753 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.325039 | 0.488 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.341959 | 0.466 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.350260 | 0.456 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.358456 | 0.446 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.227238 | 0.644 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.227238 | 0.644 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.236539 | 0.626 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.241198 | 0.618 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.273881 | 0.562 |
| R-HSA-380287 | Centrosome maturation | 0.283220 | 0.548 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.348018 | 0.458 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.193843 | 0.713 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.145750 | 0.836 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.145750 | 0.836 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.115303 | 0.938 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.357139 | 0.447 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.103654 | 0.984 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.103654 | 0.984 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.128588 | 0.891 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.128588 | 0.891 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.103654 | 0.984 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.214035 | 0.670 |
| R-HSA-169911 | Regulation of Apoptosis | 0.099891 | 1.000 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.236539 | 0.626 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.150112 | 0.824 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.366550 | 0.436 |
| R-HSA-69109 | Leading Strand Synthesis | 0.183555 | 0.736 |
| R-HSA-69091 | Polymerase switching | 0.183555 | 0.736 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.374542 | 0.426 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.088226 | 1.054 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.366550 | 0.436 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.087832 | 1.056 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.155348 | 0.809 |
| R-HSA-8849473 | PTK6 Expression | 0.119023 | 0.924 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.119023 | 0.924 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.172287 | 0.764 |
| R-HSA-9843745 | Adipogenesis | 0.118041 | 0.928 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.199002 | 0.701 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.190387 | 0.720 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.143489 | 0.843 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.278552 | 0.555 |
| R-HSA-9636569 | Suppression of autophagy | 0.084878 | 1.071 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.096404 | 1.016 |
| R-HSA-1483101 | Synthesis of PS | 0.096404 | 1.016 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.119023 | 0.924 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.141079 | 0.851 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.151900 | 0.818 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.173136 | 0.762 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.204003 | 0.690 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.214035 | 0.670 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.252920 | 0.597 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.252920 | 0.597 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.298844 | 0.525 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.316417 | 0.500 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.325039 | 0.488 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.358456 | 0.446 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.273881 | 0.562 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.132833 | 0.877 |
| R-HSA-170968 | Frs2-mediated activation | 0.193843 | 0.713 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.214035 | 0.670 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.338855 | 0.470 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.183555 | 0.736 |
| R-HSA-169893 | Prolonged ERK activation events | 0.223941 | 0.650 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.112610 | 0.948 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.128588 | 0.891 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.273881 | 0.562 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.298844 | 0.525 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.176785 | 0.753 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.213340 | 0.671 |
| R-HSA-69306 | DNA Replication | 0.173194 | 0.761 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.077535 | 1.111 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.341959 | 0.466 |
| R-HSA-8951664 | Neddylation | 0.192508 | 0.716 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.147480 | 0.831 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.200042 | 0.699 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.096404 | 1.016 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.096404 | 1.016 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.107785 | 0.967 |
| R-HSA-170984 | ARMS-mediated activation | 0.141079 | 0.851 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.173136 | 0.762 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.088226 | 1.054 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.223941 | 0.650 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.280822 | 0.552 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.316417 | 0.500 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.227238 | 0.644 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.213817 | 0.670 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.333552 | 0.477 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.181302 | 0.742 |
| R-HSA-1500620 | Meiosis | 0.329654 | 0.482 |
| R-HSA-9664873 | Pexophagy | 0.151900 | 0.818 |
| R-HSA-69239 | Synthesis of DNA | 0.192588 | 0.715 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.183555 | 0.736 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.233723 | 0.631 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.178146 | 0.749 |
| R-HSA-68882 | Mitotic Anaphase | 0.081400 | 1.089 |
| R-HSA-3928664 | Ephrin signaling | 0.252920 | 0.597 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.280822 | 0.552 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.082664 | 1.083 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.186437 | 0.729 |
| R-HSA-444821 | Relaxin receptors | 0.096404 | 1.016 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.119023 | 0.924 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.151900 | 0.818 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.173136 | 0.762 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.262338 | 0.581 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.307686 | 0.512 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.333552 | 0.477 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.341959 | 0.466 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.306509 | 0.514 |
| R-HSA-9609690 | HCMV Early Events | 0.290728 | 0.537 |
| R-HSA-379724 | tRNA Aminoacylation | 0.213340 | 0.671 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.124377 | 0.905 |
| R-HSA-190236 | Signaling by FGFR | 0.161390 | 0.792 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.325039 | 0.488 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.087108 | 1.060 |
| R-HSA-9909396 | Circadian clock | 0.120165 | 0.920 |
| R-HSA-164944 | Nef and signal transduction | 0.107785 | 0.967 |
| R-HSA-9613354 | Lipophagy | 0.141079 | 0.851 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.183555 | 0.736 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.183555 | 0.736 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.183555 | 0.736 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.077685 | 1.110 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.082338 | 1.084 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.208726 | 0.680 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.366550 | 0.436 |
| R-HSA-397014 | Muscle contraction | 0.173332 | 0.761 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.350260 | 0.456 |
| R-HSA-73886 | Chromosome Maintenance | 0.093907 | 1.027 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.214035 | 0.670 |
| R-HSA-114608 | Platelet degranulation | 0.268849 | 0.570 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.352584 | 0.453 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.146880 | 0.833 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.333552 | 0.477 |
| R-HSA-201451 | Signaling by BMP | 0.341959 | 0.466 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.193843 | 0.713 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.233723 | 0.631 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.243382 | 0.614 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.298844 | 0.525 |
| R-HSA-109704 | PI3K Cascade | 0.167808 | 0.775 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.350260 | 0.456 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.366550 | 0.436 |
| R-HSA-69481 | G2/M Checkpoints | 0.268849 | 0.570 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.124377 | 0.905 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.097151 | 1.013 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.334259 | 0.476 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.082338 | 1.084 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.329654 | 0.482 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.147059 | 0.833 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.271638 | 0.566 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.358456 | 0.446 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.334259 | 0.476 |
| R-HSA-9663891 | Selective autophagy | 0.348018 | 0.458 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.292789 | 0.533 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.271638 | 0.566 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.099891 | 1.000 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.137109 | 0.863 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.080799 | 1.093 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.263303 | 0.580 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.119023 | 0.924 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.252920 | 0.597 |
| R-HSA-70635 | Urea cycle | 0.333552 | 0.477 |
| R-HSA-3214842 | HDMs demethylate histones | 0.325039 | 0.488 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.163349 | 0.787 |
| R-HSA-112399 | IRS-mediated signalling | 0.199531 | 0.700 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.140200 | 0.853 |
| R-HSA-73884 | Base Excision Repair | 0.357139 | 0.447 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.325039 | 0.488 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.325039 | 0.488 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.152962 | 0.815 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.329654 | 0.482 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.227341 | 0.643 |
| R-HSA-373755 | Semaphorin interactions | 0.227238 | 0.644 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.316417 | 0.500 |
| R-HSA-70171 | Glycolysis | 0.167502 | 0.776 |
| R-HSA-109581 | Apoptosis | 0.195842 | 0.708 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.086440 | 1.063 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.341959 | 0.466 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.350260 | 0.456 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.217964 | 0.662 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.325039 | 0.488 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.338855 | 0.470 |
| R-HSA-1538133 | G0 and Early G1 | 0.084434 | 1.073 |
| R-HSA-162592 | Integration of provirus | 0.173136 | 0.762 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.298844 | 0.525 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.227238 | 0.644 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.370733 | 0.431 |
| R-HSA-163685 | Integration of energy metabolism | 0.306539 | 0.514 |
| R-HSA-913531 | Interferon Signaling | 0.253580 | 0.596 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.104683 | 0.980 |
| R-HSA-5357801 | Programmed Cell Death | 0.319055 | 0.496 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.231885 | 0.635 |
| R-HSA-68875 | Mitotic Prophase | 0.241800 | 0.617 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.301860 | 0.520 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.095956 | 1.018 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.236539 | 0.626 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.287886 | 0.541 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.307686 | 0.512 |
| R-HSA-70326 | Glucose metabolism | 0.231777 | 0.635 |
| R-HSA-201556 | Signaling by ALK | 0.116059 | 0.935 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.316417 | 0.500 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.316417 | 0.500 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.330652 | 0.481 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.192588 | 0.715 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.341959 | 0.466 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.316869 | 0.499 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.231885 | 0.635 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.192588 | 0.715 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.370733 | 0.431 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.236539 | 0.626 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.280822 | 0.552 |
| R-HSA-211000 | Gene Silencing by RNA | 0.192588 | 0.715 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.150112 | 0.824 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.287886 | 0.541 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.175664 | 0.755 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.343442 | 0.464 |
| R-HSA-1989781 | PPARA activates gene expression | 0.375320 | 0.426 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.379733 | 0.421 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.382151 | 0.418 |
| R-HSA-9610379 | HCMV Late Events | 0.382151 | 0.418 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.382434 | 0.417 |
| R-HSA-69190 | DNA strand elongation | 0.382434 | 0.417 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.382434 | 0.417 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.382434 | 0.417 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.384739 | 0.415 |
| R-HSA-354192 | Integrin signaling | 0.390227 | 0.409 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.390227 | 0.409 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.390227 | 0.409 |
| R-HSA-9930044 | Nuclear RNA decay | 0.390227 | 0.409 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.390227 | 0.409 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.390227 | 0.409 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.390227 | 0.409 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.390227 | 0.409 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.390227 | 0.409 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.390227 | 0.409 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.397922 | 0.400 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.397922 | 0.400 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.397922 | 0.400 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.397922 | 0.400 |
| R-HSA-8953854 | Metabolism of RNA | 0.401595 | 0.396 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.401990 | 0.396 |
| R-HSA-422356 | Regulation of insulin secretion | 0.401990 | 0.396 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.405520 | 0.392 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.405520 | 0.392 |
| R-HSA-5673000 | RAF activation | 0.405520 | 0.392 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.405520 | 0.392 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.405520 | 0.392 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.405520 | 0.392 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.405520 | 0.392 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.405520 | 0.392 |
| R-HSA-5205647 | Mitophagy | 0.405520 | 0.392 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.405520 | 0.392 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.405520 | 0.392 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.405920 | 0.392 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.406397 | 0.391 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.413023 | 0.384 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.413023 | 0.384 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.413023 | 0.384 |
| R-HSA-187687 | Signalling to ERKs | 0.413023 | 0.384 |
| R-HSA-381042 | PERK regulates gene expression | 0.413023 | 0.384 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.413023 | 0.384 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.415164 | 0.382 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.415164 | 0.382 |
| R-HSA-5619102 | SLC transporter disorders | 0.416028 | 0.381 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.420432 | 0.376 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.420432 | 0.376 |
| R-HSA-3371511 | HSF1 activation | 0.420432 | 0.376 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.420432 | 0.376 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.420432 | 0.376 |
| R-HSA-112316 | Neuronal System | 0.425438 | 0.371 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.427747 | 0.369 |
| R-HSA-4641258 | Degradation of DVL | 0.427747 | 0.369 |
| R-HSA-4641257 | Degradation of AXIN | 0.427747 | 0.369 |
| R-HSA-8948216 | Collagen chain trimerization | 0.427747 | 0.369 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.427747 | 0.369 |
| R-HSA-72306 | tRNA processing | 0.429419 | 0.367 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.432502 | 0.364 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.432502 | 0.364 |
| R-HSA-9833110 | RSV-host interactions | 0.432502 | 0.364 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.434971 | 0.362 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.434971 | 0.362 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.438506 | 0.358 |
| R-HSA-71336 | Pentose phosphate pathway | 0.442104 | 0.354 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.442104 | 0.354 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.442104 | 0.354 |
| R-HSA-69541 | Stabilization of p53 | 0.442104 | 0.354 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.446002 | 0.351 |
| R-HSA-9609646 | HCMV Infection | 0.446889 | 0.350 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.449147 | 0.348 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.449147 | 0.348 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.449147 | 0.348 |
| R-HSA-3371568 | Attenuation phase | 0.449147 | 0.348 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.449147 | 0.348 |
| R-HSA-5260271 | Diseases of Immune System | 0.449147 | 0.348 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.449147 | 0.348 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.449147 | 0.348 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.449147 | 0.348 |
| R-HSA-202433 | Generation of second messenger molecules | 0.449147 | 0.348 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.449564 | 0.347 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.456102 | 0.341 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.456102 | 0.341 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.456102 | 0.341 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.456102 | 0.341 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.456102 | 0.341 |
| R-HSA-202403 | TCR signaling | 0.457986 | 0.339 |
| R-HSA-5688426 | Deubiquitination | 0.460773 | 0.337 |
| R-HSA-167161 | HIV Transcription Initiation | 0.462969 | 0.334 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.462969 | 0.334 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.462969 | 0.334 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.462969 | 0.334 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.462969 | 0.334 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.462969 | 0.334 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.462969 | 0.334 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.462969 | 0.334 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.462969 | 0.334 |
| R-HSA-165159 | MTOR signalling | 0.469751 | 0.328 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.469751 | 0.328 |
| R-HSA-73928 | Depyrimidination | 0.469751 | 0.328 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.469751 | 0.328 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.476447 | 0.322 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.476447 | 0.322 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.476447 | 0.322 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.478713 | 0.320 |
| R-HSA-9907900 | Proteasome assembly | 0.483058 | 0.316 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.483058 | 0.316 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.483058 | 0.316 |
| R-HSA-156581 | Methylation | 0.483058 | 0.316 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.489587 | 0.310 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.489587 | 0.310 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.489587 | 0.310 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.489587 | 0.310 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.489587 | 0.310 |
| R-HSA-9824272 | Somitogenesis | 0.489587 | 0.310 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.489587 | 0.310 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.494944 | 0.305 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.496034 | 0.304 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.496034 | 0.304 |
| R-HSA-9675135 | Diseases of DNA repair | 0.496034 | 0.304 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.498952 | 0.302 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.500844 | 0.300 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.502399 | 0.299 |
| R-HSA-1483191 | Synthesis of PC | 0.502399 | 0.299 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.502939 | 0.298 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.508685 | 0.294 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.508685 | 0.294 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.510853 | 0.292 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.512340 | 0.290 |
| R-HSA-9766229 | Degradation of CDH1 | 0.514891 | 0.288 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.514891 | 0.288 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.514891 | 0.288 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.518684 | 0.285 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.521020 | 0.283 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.525216 | 0.280 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.527071 | 0.278 |
| R-HSA-912446 | Meiotic recombination | 0.527071 | 0.278 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.527071 | 0.278 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.527071 | 0.278 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.527071 | 0.278 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.533047 | 0.273 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.533047 | 0.273 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.533047 | 0.273 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.533047 | 0.273 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.534836 | 0.272 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.538947 | 0.268 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.538947 | 0.268 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.538947 | 0.268 |
| R-HSA-1221632 | Meiotic synapsis | 0.538947 | 0.268 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.538947 | 0.268 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.538947 | 0.268 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.538947 | 0.268 |
| R-HSA-72649 | Translation initiation complex formation | 0.544773 | 0.264 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.544773 | 0.264 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.544773 | 0.264 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.544773 | 0.264 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.549167 | 0.260 |
| R-HSA-418597 | G alpha (z) signalling events | 0.550526 | 0.259 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.550526 | 0.259 |
| R-HSA-1474165 | Reproduction | 0.552881 | 0.257 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.554357 | 0.256 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.556207 | 0.255 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.556207 | 0.255 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.556207 | 0.255 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.556207 | 0.255 |
| R-HSA-5578775 | Ion homeostasis | 0.556207 | 0.255 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.556207 | 0.255 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.561816 | 0.250 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.561816 | 0.250 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.564582 | 0.248 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.567354 | 0.246 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.567354 | 0.246 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.567354 | 0.246 |
| R-HSA-162582 | Signal Transduction | 0.572708 | 0.242 |
| R-HSA-180786 | Extension of Telomeres | 0.572823 | 0.242 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.572823 | 0.242 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.572823 | 0.242 |
| R-HSA-983189 | Kinesins | 0.578223 | 0.238 |
| R-HSA-351202 | Metabolism of polyamines | 0.578223 | 0.238 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.578223 | 0.238 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.578223 | 0.238 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.578223 | 0.238 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.578223 | 0.238 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.578223 | 0.238 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.578223 | 0.238 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.578278 | 0.238 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.578278 | 0.238 |
| R-HSA-422475 | Axon guidance | 0.578396 | 0.238 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.581820 | 0.235 |
| R-HSA-211976 | Endogenous sterols | 0.583555 | 0.234 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.583555 | 0.234 |
| R-HSA-112043 | PLC beta mediated events | 0.583555 | 0.234 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.583555 | 0.234 |
| R-HSA-1442490 | Collagen degradation | 0.583555 | 0.234 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.585339 | 0.233 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.588820 | 0.230 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.588820 | 0.230 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.588820 | 0.230 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.594019 | 0.226 |
| R-HSA-8848021 | Signaling by PTK6 | 0.594019 | 0.226 |
| R-HSA-1632852 | Macroautophagy | 0.595767 | 0.225 |
| R-HSA-9824446 | Viral Infection Pathways | 0.597671 | 0.224 |
| R-HSA-112040 | G-protein mediated events | 0.614168 | 0.212 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.614168 | 0.212 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.614168 | 0.212 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.619048 | 0.208 |
| R-HSA-167172 | Transcription of the HIV genome | 0.619048 | 0.208 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.619048 | 0.208 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.619048 | 0.208 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.628624 | 0.202 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.628624 | 0.202 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.628624 | 0.202 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.629107 | 0.201 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.629107 | 0.201 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.633322 | 0.198 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.633322 | 0.198 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.633322 | 0.198 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.633322 | 0.198 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.633322 | 0.198 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.633322 | 0.198 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.633501 | 0.198 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.635515 | 0.197 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.635515 | 0.197 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.637960 | 0.195 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.637960 | 0.195 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.637960 | 0.195 |
| R-HSA-157118 | Signaling by NOTCH | 0.641446 | 0.193 |
| R-HSA-4086398 | Ca2+ pathway | 0.642541 | 0.192 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.642541 | 0.192 |
| R-HSA-9675108 | Nervous system development | 0.644756 | 0.191 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.647063 | 0.189 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.647063 | 0.189 |
| R-HSA-9612973 | Autophagy | 0.648070 | 0.188 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.651529 | 0.186 |
| R-HSA-8852135 | Protein ubiquitination | 0.651529 | 0.186 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.651529 | 0.186 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.651529 | 0.186 |
| R-HSA-5689603 | UCH proteinases | 0.655938 | 0.183 |
| R-HSA-877300 | Interferon gamma signaling | 0.657261 | 0.182 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.660282 | 0.180 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.660282 | 0.180 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.660292 | 0.180 |
| R-HSA-216083 | Integrin cell surface interactions | 0.664592 | 0.177 |
| R-HSA-5619084 | ABC transporter disorders | 0.664592 | 0.177 |
| R-HSA-4086400 | PCP/CE pathway | 0.664592 | 0.177 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.673028 | 0.172 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.673028 | 0.172 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.674957 | 0.171 |
| R-HSA-72766 | Translation | 0.676452 | 0.170 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.677167 | 0.169 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.685288 | 0.164 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.689273 | 0.162 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.689273 | 0.162 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.689393 | 0.162 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.692121 | 0.160 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.694890 | 0.158 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.700927 | 0.154 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.704714 | 0.152 |
| R-HSA-156902 | Peptide chain elongation | 0.708453 | 0.150 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.708453 | 0.150 |
| R-HSA-449147 | Signaling by Interleukins | 0.713770 | 0.146 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.715792 | 0.145 |
| R-HSA-202424 | Downstream TCR signaling | 0.715792 | 0.145 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.719391 | 0.143 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.719391 | 0.143 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.722946 | 0.141 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.726456 | 0.139 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.733343 | 0.135 |
| R-HSA-1474290 | Collagen formation | 0.733343 | 0.135 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.736721 | 0.133 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.738902 | 0.131 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.740057 | 0.131 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.740057 | 0.131 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.740057 | 0.131 |
| R-HSA-9679506 | SARS-CoV Infections | 0.740495 | 0.130 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.743351 | 0.129 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.743351 | 0.129 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.743351 | 0.129 |
| R-HSA-1296071 | Potassium Channels | 0.743351 | 0.129 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.743351 | 0.129 |
| R-HSA-5617833 | Cilium Assembly | 0.743709 | 0.129 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.746084 | 0.127 |
| R-HSA-157579 | Telomere Maintenance | 0.746604 | 0.127 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.746604 | 0.127 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.746604 | 0.127 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.749815 | 0.125 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.752986 | 0.123 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.753096 | 0.123 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.756117 | 0.121 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.756117 | 0.121 |
| R-HSA-1483255 | PI Metabolism | 0.762261 | 0.118 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.762261 | 0.118 |
| R-HSA-1483257 | Phospholipid metabolism | 0.763400 | 0.117 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.763400 | 0.117 |
| R-HSA-192823 | Viral mRNA Translation | 0.765275 | 0.116 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.765275 | 0.116 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.768251 | 0.114 |
| R-HSA-111885 | Opioid Signalling | 0.768251 | 0.114 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.773145 | 0.112 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.774090 | 0.111 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.776955 | 0.110 |
| R-HSA-72172 | mRNA Splicing | 0.777404 | 0.109 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.779783 | 0.108 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.782576 | 0.106 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.782576 | 0.106 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.782576 | 0.106 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.782576 | 0.106 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.785334 | 0.105 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.788056 | 0.103 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.793399 | 0.101 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.793399 | 0.101 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.793399 | 0.101 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.803686 | 0.095 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.806177 | 0.094 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.806177 | 0.094 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.806177 | 0.094 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.808637 | 0.092 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.808637 | 0.092 |
| R-HSA-373760 | L1CAM interactions | 0.808637 | 0.092 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.815831 | 0.088 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.815831 | 0.088 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.819824 | 0.086 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.822756 | 0.085 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.822756 | 0.085 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.822836 | 0.085 |
| R-HSA-1474244 | Extracellular matrix organization | 0.823441 | 0.084 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.825006 | 0.084 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.826715 | 0.083 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.828725 | 0.082 |
| R-HSA-72312 | rRNA processing | 0.830071 | 0.081 |
| R-HSA-194138 | Signaling by VEGF | 0.831587 | 0.080 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.837922 | 0.077 |
| R-HSA-8939211 | ESR-mediated signaling | 0.838207 | 0.077 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.841363 | 0.075 |
| R-HSA-74160 | Gene expression (Transcription) | 0.842126 | 0.075 |
| R-HSA-5576891 | Cardiac conduction | 0.846002 | 0.073 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.847958 | 0.072 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.847958 | 0.072 |
| R-HSA-199991 | Membrane Trafficking | 0.854090 | 0.068 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.855441 | 0.068 |
| R-HSA-5368287 | Mitochondrial translation | 0.860978 | 0.065 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.860978 | 0.065 |
| R-HSA-6807070 | PTEN Regulation | 0.862745 | 0.064 |
| R-HSA-597592 | Post-translational protein modification | 0.865145 | 0.063 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.865456 | 0.063 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.872887 | 0.059 |
| R-HSA-416476 | G alpha (q) signalling events | 0.876363 | 0.057 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.877675 | 0.057 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.879231 | 0.056 |
| R-HSA-166520 | Signaling by NTRKs | 0.879231 | 0.056 |
| R-HSA-9758941 | Gastrulation | 0.880767 | 0.055 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.888028 | 0.052 |
| R-HSA-109582 | Hemostasis | 0.888048 | 0.052 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.892722 | 0.049 |
| R-HSA-9711097 | Cellular response to starvation | 0.893746 | 0.049 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.893746 | 0.049 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.897015 | 0.047 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.905318 | 0.043 |
| R-HSA-418555 | G alpha (s) signalling events | 0.911195 | 0.040 |
| R-HSA-195721 | Signaling by WNT | 0.912641 | 0.040 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.913444 | 0.039 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.913444 | 0.039 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.914546 | 0.039 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.915635 | 0.038 |
| R-HSA-211859 | Biological oxidations | 0.916068 | 0.038 |
| R-HSA-611105 | Respiratory electron transport | 0.918819 | 0.037 |
| R-HSA-2559583 | Cellular Senescence | 0.920875 | 0.036 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.923862 | 0.034 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.926737 | 0.033 |
| R-HSA-983712 | Ion channel transport | 0.929504 | 0.032 |
| R-HSA-8957322 | Metabolism of steroids | 0.933396 | 0.030 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.935563 | 0.029 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.938789 | 0.027 |
| R-HSA-428157 | Sphingolipid metabolism | 0.939570 | 0.027 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.940341 | 0.027 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.947192 | 0.024 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.948866 | 0.023 |
| R-HSA-1266738 | Developmental Biology | 0.949291 | 0.023 |
| R-HSA-418990 | Adherens junctions interactions | 0.952050 | 0.021 |
| R-HSA-5663205 | Infectious disease | 0.954846 | 0.020 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.956484 | 0.019 |
| R-HSA-1280218 | Adaptive Immune System | 0.963626 | 0.016 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.967515 | 0.014 |
| R-HSA-421270 | Cell-cell junction organization | 0.968645 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 0.969842 | 0.013 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.973138 | 0.012 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.974986 | 0.011 |
| R-HSA-446728 | Cell junction organization | 0.977864 | 0.010 |
| R-HSA-1643685 | Disease | 0.978294 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 0.984509 | 0.007 |
| R-HSA-1500931 | Cell-Cell communication | 0.986454 | 0.006 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.990200 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.995138 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.995324 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 0.995895 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.996623 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.996836 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.997796 | 0.001 |
| R-HSA-168256 | Immune System | 0.998253 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 0.998528 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999120 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999578 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999621 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999700 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999785 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999997 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK16 |
0.835 | 0.741 | 1 | 0.886 |
CDK18 |
0.833 | 0.712 | 1 | 0.872 |
CDK17 |
0.832 | 0.720 | 1 | 0.896 |
KIS |
0.832 | 0.636 | 1 | 0.810 |
CDK19 |
0.828 | 0.674 | 1 | 0.858 |
CDK3 |
0.827 | 0.642 | 1 | 0.891 |
CDK1 |
0.825 | 0.689 | 1 | 0.853 |
P38G |
0.823 | 0.713 | 1 | 0.902 |
CDK8 |
0.822 | 0.673 | 1 | 0.827 |
CDK7 |
0.822 | 0.684 | 1 | 0.833 |
CDK5 |
0.820 | 0.677 | 1 | 0.807 |
CDK10 |
0.820 | 0.679 | 1 | 0.851 |
HIPK2 |
0.819 | 0.625 | 1 | 0.850 |
JNK2 |
0.819 | 0.718 | 1 | 0.870 |
ERK1 |
0.818 | 0.688 | 1 | 0.854 |
CDK14 |
0.814 | 0.695 | 1 | 0.836 |
P38D |
0.813 | 0.687 | 1 | 0.905 |
P38B |
0.812 | 0.690 | 1 | 0.839 |
CDK13 |
0.811 | 0.654 | 1 | 0.853 |
CLK3 |
0.811 | 0.466 | 1 | 0.553 |
CDK12 |
0.807 | 0.650 | 1 | 0.871 |
P38A |
0.806 | 0.686 | 1 | 0.777 |
ERK2 |
0.805 | 0.685 | 1 | 0.810 |
CDK9 |
0.805 | 0.650 | 1 | 0.846 |
CDK6 |
0.805 | 0.668 | 1 | 0.853 |
JNK3 |
0.804 | 0.676 | 1 | 0.848 |
DYRK2 |
0.803 | 0.594 | 1 | 0.771 |
CDK4 |
0.803 | 0.675 | 1 | 0.877 |
DYRK1B |
0.801 | 0.600 | 1 | 0.824 |
HIPK1 |
0.801 | 0.570 | 1 | 0.754 |
DYRK4 |
0.797 | 0.600 | 1 | 0.861 |
NLK |
0.796 | 0.620 | 1 | 0.579 |
CDK2 |
0.795 | 0.550 | 1 | 0.735 |
HIPK4 |
0.794 | 0.399 | 1 | 0.571 |
SRPK1 |
0.790 | 0.295 | -3 | 0.655 |
DYRK1A |
0.789 | 0.502 | 1 | 0.744 |
HIPK3 |
0.788 | 0.545 | 1 | 0.728 |
SRPK2 |
0.785 | 0.249 | -3 | 0.580 |
ERK5 |
0.784 | 0.343 | 1 | 0.493 |
CLK1 |
0.783 | 0.354 | -3 | 0.657 |
JNK1 |
0.783 | 0.607 | 1 | 0.870 |
CLK2 |
0.780 | 0.354 | -3 | 0.653 |
MAK |
0.779 | 0.448 | -2 | 0.847 |
ICK |
0.778 | 0.344 | -3 | 0.754 |
CDKL5 |
0.778 | 0.191 | -3 | 0.710 |
DYRK3 |
0.777 | 0.432 | 1 | 0.717 |
CLK4 |
0.776 | 0.314 | -3 | 0.675 |
MTOR |
0.776 | 0.200 | 1 | 0.373 |
MOK |
0.775 | 0.430 | 1 | 0.644 |
COT |
0.771 | -0.003 | 2 | 0.867 |
CDKL1 |
0.770 | 0.150 | -3 | 0.717 |
SRPK3 |
0.764 | 0.195 | -3 | 0.627 |
NDR2 |
0.763 | 0.038 | -3 | 0.759 |
MST4 |
0.763 | 0.074 | 2 | 0.850 |
NDR1 |
0.761 | 0.073 | -3 | 0.750 |
PRP4 |
0.761 | 0.356 | -3 | 0.683 |
PIM3 |
0.760 | 0.024 | -3 | 0.745 |
CDC7 |
0.759 | -0.076 | 1 | 0.213 |
CHAK2 |
0.758 | 0.031 | -1 | 0.904 |
TBK1 |
0.757 | -0.096 | 1 | 0.174 |
PRPK |
0.757 | -0.041 | -1 | 0.850 |
WNK1 |
0.757 | 0.037 | -2 | 0.838 |
PIM1 |
0.756 | 0.080 | -3 | 0.690 |
MOS |
0.756 | -0.035 | 1 | 0.254 |
PKCD |
0.754 | 0.035 | 2 | 0.794 |
ERK7 |
0.754 | 0.221 | 2 | 0.509 |
RAF1 |
0.753 | -0.096 | 1 | 0.199 |
RSK2 |
0.753 | 0.031 | -3 | 0.689 |
GCN2 |
0.753 | -0.139 | 2 | 0.768 |
ULK2 |
0.752 | -0.106 | 2 | 0.782 |
ATR |
0.752 | -0.049 | 1 | 0.249 |
NUAK2 |
0.751 | 0.015 | -3 | 0.757 |
IRE1 |
0.750 | 0.002 | 1 | 0.195 |
PKN3 |
0.750 | -0.037 | -3 | 0.738 |
CAMK1B |
0.750 | -0.034 | -3 | 0.782 |
NIK |
0.750 | 0.014 | -3 | 0.804 |
LATS2 |
0.750 | -0.024 | -5 | 0.436 |
NEK6 |
0.749 | -0.059 | -2 | 0.791 |
PKN2 |
0.749 | -0.016 | -3 | 0.752 |
TGFBR2 |
0.749 | -0.043 | -2 | 0.755 |
P70S6KB |
0.749 | 0.047 | -3 | 0.710 |
P90RSK |
0.749 | 0.021 | -3 | 0.687 |
PDHK4 |
0.749 | -0.166 | 1 | 0.262 |
PRKD2 |
0.748 | -0.018 | -3 | 0.688 |
IKKE |
0.748 | -0.149 | 1 | 0.174 |
BMPR2 |
0.748 | -0.157 | -2 | 0.847 |
RSK3 |
0.748 | 0.012 | -3 | 0.677 |
DSTYK |
0.748 | -0.112 | 2 | 0.862 |
IRE2 |
0.747 | 0.020 | 2 | 0.760 |
PIM2 |
0.747 | 0.109 | -3 | 0.658 |
AURC |
0.746 | 0.036 | -2 | 0.602 |
PKACG |
0.745 | 0.013 | -2 | 0.697 |
MLK3 |
0.745 | 0.011 | 2 | 0.745 |
RIPK3 |
0.745 | -0.070 | 3 | 0.737 |
AMPKA1 |
0.745 | -0.034 | -3 | 0.770 |
PRKD1 |
0.745 | -0.073 | -3 | 0.743 |
IKKB |
0.744 | -0.187 | -2 | 0.728 |
MLK1 |
0.744 | -0.104 | 2 | 0.807 |
NEK7 |
0.744 | -0.131 | -3 | 0.823 |
PKCG |
0.744 | 0.035 | 2 | 0.744 |
MPSK1 |
0.744 | 0.096 | 1 | 0.261 |
ULK1 |
0.743 | -0.112 | -3 | 0.782 |
RSK4 |
0.743 | 0.056 | -3 | 0.659 |
WNK3 |
0.743 | -0.101 | 1 | 0.197 |
PKCA |
0.743 | 0.025 | 2 | 0.737 |
PDHK1 |
0.743 | -0.182 | 1 | 0.241 |
PKCB |
0.743 | 0.027 | 2 | 0.743 |
CAMLCK |
0.743 | -0.018 | -2 | 0.802 |
CAMK2G |
0.742 | -0.091 | 2 | 0.785 |
PHKG1 |
0.741 | -0.020 | -3 | 0.738 |
MAPKAPK3 |
0.741 | -0.086 | -3 | 0.689 |
AMPKA2 |
0.741 | -0.031 | -3 | 0.738 |
MLK2 |
0.741 | -0.079 | 2 | 0.809 |
MNK1 |
0.740 | 0.019 | -2 | 0.740 |
LATS1 |
0.740 | 0.009 | -3 | 0.777 |
MNK2 |
0.739 | -0.014 | -2 | 0.725 |
SKMLCK |
0.739 | -0.068 | -2 | 0.803 |
PINK1 |
0.738 | 0.131 | 1 | 0.408 |
CHAK1 |
0.738 | -0.036 | 2 | 0.779 |
PKR |
0.738 | -0.022 | 1 | 0.217 |
MARK4 |
0.738 | -0.061 | 4 | 0.796 |
NEK9 |
0.737 | -0.130 | 2 | 0.825 |
PKCZ |
0.737 | -0.017 | 2 | 0.774 |
NIM1 |
0.737 | -0.035 | 3 | 0.783 |
DAPK2 |
0.737 | -0.065 | -3 | 0.790 |
PAK3 |
0.737 | -0.026 | -2 | 0.741 |
BCKDK |
0.737 | -0.127 | -1 | 0.817 |
GRK1 |
0.737 | -0.064 | -2 | 0.793 |
PAK1 |
0.736 | -0.011 | -2 | 0.746 |
PRKD3 |
0.736 | -0.032 | -3 | 0.655 |
HUNK |
0.736 | -0.123 | 2 | 0.793 |
PKCH |
0.736 | 0.000 | 2 | 0.727 |
NUAK1 |
0.736 | -0.032 | -3 | 0.706 |
GRK5 |
0.735 | -0.161 | -3 | 0.786 |
IKKA |
0.735 | -0.128 | -2 | 0.723 |
MELK |
0.735 | -0.041 | -3 | 0.723 |
PKG2 |
0.735 | 0.019 | -2 | 0.629 |
PAK6 |
0.735 | -0.006 | -2 | 0.665 |
MAPKAPK2 |
0.734 | -0.072 | -3 | 0.642 |
ALK4 |
0.734 | -0.035 | -2 | 0.814 |
AKT2 |
0.734 | 0.024 | -3 | 0.598 |
PKACB |
0.733 | 0.027 | -2 | 0.612 |
SGK3 |
0.733 | 0.016 | -3 | 0.668 |
TSSK1 |
0.732 | -0.090 | -3 | 0.792 |
PRKX |
0.732 | 0.042 | -3 | 0.589 |
RIPK1 |
0.732 | -0.157 | 1 | 0.186 |
DNAPK |
0.732 | -0.034 | 1 | 0.233 |
DLK |
0.732 | -0.175 | 1 | 0.206 |
GRK7 |
0.732 | -0.026 | 1 | 0.224 |
BMPR1B |
0.732 | -0.048 | 1 | 0.178 |
AURB |
0.732 | -0.003 | -2 | 0.595 |
PHKG2 |
0.731 | -0.007 | -3 | 0.714 |
IRAK4 |
0.731 | -0.014 | 1 | 0.180 |
CAMK4 |
0.731 | -0.110 | -3 | 0.738 |
MASTL |
0.731 | -0.188 | -2 | 0.790 |
QIK |
0.731 | -0.060 | -3 | 0.758 |
NEK2 |
0.731 | -0.079 | 2 | 0.801 |
VRK2 |
0.730 | 0.005 | 1 | 0.297 |
ANKRD3 |
0.730 | -0.147 | 1 | 0.213 |
TSSK2 |
0.730 | -0.131 | -5 | 0.396 |
CAMK2D |
0.730 | -0.132 | -3 | 0.762 |
MST3 |
0.730 | 0.048 | 2 | 0.827 |
TTBK2 |
0.730 | -0.142 | 2 | 0.694 |
MLK4 |
0.729 | -0.070 | 2 | 0.708 |
TGFBR1 |
0.728 | -0.055 | -2 | 0.784 |
YSK4 |
0.728 | -0.139 | 1 | 0.180 |
PKCI |
0.728 | 0.024 | 2 | 0.740 |
PKCT |
0.727 | -0.006 | 2 | 0.736 |
PAK2 |
0.727 | -0.039 | -2 | 0.731 |
PKCE |
0.727 | 0.046 | 2 | 0.733 |
CHK1 |
0.726 | -0.104 | -3 | 0.760 |
ATM |
0.726 | -0.100 | 1 | 0.217 |
GRK6 |
0.726 | -0.153 | 1 | 0.195 |
GSK3A |
0.725 | 0.140 | 4 | 0.415 |
WNK4 |
0.725 | -0.063 | -2 | 0.837 |
AKT1 |
0.725 | 0.006 | -3 | 0.617 |
MSK2 |
0.725 | -0.064 | -3 | 0.648 |
TAO3 |
0.725 | 0.005 | 1 | 0.226 |
HRI |
0.724 | -0.103 | -2 | 0.806 |
ZAK |
0.724 | -0.072 | 1 | 0.186 |
P70S6K |
0.724 | -0.004 | -3 | 0.621 |
DCAMKL1 |
0.723 | -0.024 | -3 | 0.695 |
FAM20C |
0.723 | -0.025 | 2 | 0.609 |
PERK |
0.723 | -0.104 | -2 | 0.800 |
SIK |
0.723 | -0.057 | -3 | 0.671 |
CAMK1G |
0.723 | -0.044 | -3 | 0.674 |
QSK |
0.722 | -0.072 | 4 | 0.775 |
MEK1 |
0.722 | -0.149 | 2 | 0.814 |
MYLK4 |
0.722 | -0.037 | -2 | 0.709 |
BRSK2 |
0.722 | -0.081 | -3 | 0.728 |
MRCKA |
0.721 | 0.103 | -3 | 0.663 |
CK1E |
0.721 | -0.004 | -3 | 0.513 |
PLK1 |
0.721 | -0.139 | -2 | 0.743 |
GRK4 |
0.721 | -0.174 | -2 | 0.788 |
BUB1 |
0.720 | 0.010 | -5 | 0.370 |
MEK5 |
0.720 | -0.112 | 2 | 0.810 |
SMG1 |
0.720 | -0.109 | 1 | 0.232 |
ACVR2A |
0.719 | -0.100 | -2 | 0.752 |
ALK2 |
0.719 | -0.074 | -2 | 0.789 |
DCAMKL2 |
0.719 | -0.034 | -3 | 0.727 |
DRAK1 |
0.719 | -0.087 | 1 | 0.167 |
TAO2 |
0.719 | 0.016 | 2 | 0.850 |
CAMK2A |
0.719 | -0.076 | 2 | 0.760 |
MARK3 |
0.719 | -0.051 | 4 | 0.733 |
PLK4 |
0.718 | -0.107 | 2 | 0.616 |
ACVR2B |
0.717 | -0.116 | -2 | 0.763 |
NEK5 |
0.717 | -0.110 | 1 | 0.195 |
MEKK1 |
0.717 | -0.148 | 1 | 0.205 |
MEKK2 |
0.717 | -0.101 | 2 | 0.791 |
CAMK2B |
0.716 | -0.107 | 2 | 0.745 |
BRSK1 |
0.716 | -0.084 | -3 | 0.698 |
LKB1 |
0.716 | 0.007 | -3 | 0.785 |
MEKK3 |
0.716 | -0.138 | 1 | 0.198 |
AKT3 |
0.716 | 0.025 | -3 | 0.533 |
MSK1 |
0.716 | -0.059 | -3 | 0.652 |
PKN1 |
0.716 | -0.032 | -3 | 0.638 |
BRAF |
0.716 | -0.088 | -4 | 0.846 |
PAK5 |
0.715 | -0.032 | -2 | 0.600 |
PASK |
0.715 | -0.021 | -3 | 0.773 |
TLK2 |
0.715 | -0.152 | 1 | 0.188 |
GAK |
0.715 | -0.013 | 1 | 0.252 |
LOK |
0.715 | 0.025 | -2 | 0.739 |
SGK1 |
0.715 | 0.046 | -3 | 0.517 |
BMPR1A |
0.715 | -0.060 | 1 | 0.168 |
MRCKB |
0.715 | 0.052 | -3 | 0.645 |
PKACA |
0.715 | -0.005 | -2 | 0.565 |
GRK2 |
0.714 | -0.090 | -2 | 0.689 |
SNRK |
0.714 | -0.133 | 2 | 0.671 |
HGK |
0.714 | -0.018 | 3 | 0.914 |
PLK3 |
0.714 | -0.102 | 2 | 0.745 |
ROCK2 |
0.714 | 0.062 | -3 | 0.695 |
MARK2 |
0.714 | -0.081 | 4 | 0.692 |
TNIK |
0.714 | 0.007 | 3 | 0.923 |
MAPKAPK5 |
0.713 | -0.121 | -3 | 0.631 |
SMMLCK |
0.713 | -0.047 | -3 | 0.734 |
HASPIN |
0.713 | 0.046 | -1 | 0.740 |
PBK |
0.713 | 0.008 | 1 | 0.231 |
GCK |
0.713 | -0.031 | 1 | 0.206 |
NEK11 |
0.712 | -0.106 | 1 | 0.220 |
SSTK |
0.712 | -0.078 | 4 | 0.766 |
EEF2K |
0.711 | -0.009 | 3 | 0.878 |
MAP3K15 |
0.711 | -0.058 | 1 | 0.199 |
AURA |
0.711 | -0.055 | -2 | 0.557 |
MEKK6 |
0.710 | -0.043 | 1 | 0.202 |
KHS2 |
0.710 | 0.027 | 1 | 0.212 |
MARK1 |
0.710 | -0.088 | 4 | 0.757 |
KHS1 |
0.710 | -0.002 | 1 | 0.201 |
NEK4 |
0.710 | -0.083 | 1 | 0.181 |
NEK8 |
0.709 | -0.115 | 2 | 0.815 |
DMPK1 |
0.709 | 0.087 | -3 | 0.668 |
LRRK2 |
0.709 | -0.000 | 2 | 0.833 |
SLK |
0.709 | -0.010 | -2 | 0.698 |
TTBK1 |
0.709 | -0.122 | 2 | 0.628 |
TLK1 |
0.708 | -0.143 | -2 | 0.772 |
GSK3B |
0.708 | 0.011 | 4 | 0.403 |
MINK |
0.708 | -0.075 | 1 | 0.183 |
PDK1 |
0.708 | -0.088 | 1 | 0.238 |
HPK1 |
0.708 | -0.025 | 1 | 0.207 |
CK1D |
0.708 | -0.013 | -3 | 0.461 |
PAK4 |
0.706 | -0.043 | -2 | 0.599 |
NEK1 |
0.706 | -0.064 | 1 | 0.177 |
CAMK1D |
0.705 | -0.064 | -3 | 0.593 |
SBK |
0.705 | 0.039 | -3 | 0.484 |
CAMKK1 |
0.705 | -0.139 | -2 | 0.734 |
YSK1 |
0.705 | -0.027 | 2 | 0.802 |
IRAK1 |
0.704 | -0.172 | -1 | 0.784 |
CK1G1 |
0.704 | -0.054 | -3 | 0.489 |
MST1 |
0.703 | -0.069 | 1 | 0.181 |
MST2 |
0.702 | -0.131 | 1 | 0.191 |
CK1A2 |
0.702 | -0.028 | -3 | 0.459 |
CHK2 |
0.701 | -0.058 | -3 | 0.543 |
CRIK |
0.701 | 0.020 | -3 | 0.616 |
CAMKK2 |
0.701 | -0.129 | -2 | 0.732 |
STK33 |
0.701 | -0.055 | 2 | 0.614 |
ROCK1 |
0.700 | 0.036 | -3 | 0.659 |
DAPK3 |
0.700 | -0.046 | -3 | 0.707 |
NEK3 |
0.698 | -0.076 | 1 | 0.202 |
BIKE |
0.698 | -0.029 | 1 | 0.237 |
AAK1 |
0.697 | -0.000 | 1 | 0.240 |
TAK1 |
0.696 | -0.162 | 1 | 0.189 |
LIMK2_TYR |
0.696 | 0.201 | -3 | 0.829 |
GRK3 |
0.695 | -0.104 | -2 | 0.645 |
CAMK1A |
0.695 | -0.070 | -3 | 0.559 |
VRK1 |
0.694 | -0.159 | 2 | 0.831 |
PDHK3_TYR |
0.694 | 0.143 | 4 | 0.871 |
TAO1 |
0.693 | -0.024 | 1 | 0.193 |
CK2A2 |
0.692 | -0.088 | 1 | 0.156 |
DAPK1 |
0.692 | -0.054 | -3 | 0.689 |
RIPK2 |
0.692 | -0.178 | 1 | 0.171 |
TESK1_TYR |
0.692 | 0.141 | 3 | 0.902 |
PKG1 |
0.691 | -0.045 | -2 | 0.544 |
MYO3B |
0.689 | -0.033 | 2 | 0.822 |
MEK2 |
0.689 | -0.165 | 2 | 0.787 |
PKMYT1_TYR |
0.688 | 0.132 | 3 | 0.864 |
MYO3A |
0.688 | -0.036 | 1 | 0.200 |
ASK1 |
0.686 | -0.081 | 1 | 0.199 |
OSR1 |
0.686 | -0.074 | 2 | 0.779 |
PLK2 |
0.685 | -0.081 | -3 | 0.780 |
TTK |
0.685 | -0.070 | -2 | 0.757 |
CK2A1 |
0.684 | -0.090 | 1 | 0.146 |
PDHK4_TYR |
0.682 | 0.022 | 2 | 0.857 |
LIMK1_TYR |
0.680 | 0.052 | 2 | 0.851 |
PINK1_TYR |
0.680 | -0.045 | 1 | 0.253 |
MAP2K7_TYR |
0.679 | -0.055 | 2 | 0.844 |
MAP2K4_TYR |
0.677 | -0.067 | -1 | 0.857 |
RET |
0.677 | -0.052 | 1 | 0.219 |
ALPHAK3 |
0.676 | -0.089 | -1 | 0.749 |
MAP2K6_TYR |
0.675 | -0.052 | -1 | 0.866 |
PDHK1_TYR |
0.674 | -0.065 | -1 | 0.878 |
NEK10_TYR |
0.673 | -0.043 | 1 | 0.201 |
TYK2 |
0.673 | -0.136 | 1 | 0.209 |
JAK2 |
0.673 | -0.096 | 1 | 0.229 |
BMPR2_TYR |
0.673 | -0.045 | -1 | 0.837 |
MST1R |
0.673 | -0.064 | 3 | 0.837 |
TNNI3K_TYR |
0.672 | -0.002 | 1 | 0.231 |
ROS1 |
0.671 | -0.078 | 3 | 0.811 |
CSF1R |
0.670 | -0.074 | 3 | 0.816 |
TNK1 |
0.669 | -0.002 | 3 | 0.815 |
TYRO3 |
0.669 | -0.101 | 3 | 0.843 |
JAK1 |
0.668 | -0.055 | 1 | 0.195 |
EPHA6 |
0.667 | -0.075 | -1 | 0.821 |
YES1 |
0.665 | -0.055 | -1 | 0.840 |
JAK3 |
0.665 | -0.094 | 1 | 0.211 |
DDR1 |
0.664 | -0.077 | 4 | 0.781 |
ABL2 |
0.664 | -0.086 | -1 | 0.773 |
EPHB4 |
0.664 | -0.104 | -1 | 0.804 |
YANK3 |
0.664 | -0.062 | 2 | 0.404 |
FGFR2 |
0.662 | -0.022 | 3 | 0.780 |
CK1A |
0.662 | -0.061 | -3 | 0.372 |
STLK3 |
0.662 | -0.178 | 1 | 0.170 |
TEK |
0.661 | -0.004 | 3 | 0.756 |
ABL1 |
0.661 | -0.083 | -1 | 0.771 |
FLT3 |
0.661 | -0.115 | 3 | 0.833 |
FGFR1 |
0.661 | -0.040 | 3 | 0.774 |
KDR |
0.661 | -0.042 | 3 | 0.763 |
TNK2 |
0.661 | -0.087 | 3 | 0.765 |
LCK |
0.659 | -0.083 | -1 | 0.796 |
WEE1_TYR |
0.659 | -0.041 | -1 | 0.742 |
TXK |
0.659 | -0.083 | 1 | 0.171 |
INSRR |
0.659 | -0.091 | 3 | 0.759 |
PDGFRB |
0.659 | -0.145 | 3 | 0.831 |
FGR |
0.658 | -0.140 | 1 | 0.184 |
ITK |
0.657 | -0.113 | -1 | 0.767 |
KIT |
0.657 | -0.112 | 3 | 0.808 |
HCK |
0.656 | -0.129 | -1 | 0.792 |
PDGFRA |
0.656 | -0.145 | 3 | 0.834 |
BLK |
0.655 | -0.079 | -1 | 0.799 |
EPHA4 |
0.653 | -0.093 | 2 | 0.748 |
FER |
0.653 | -0.187 | 1 | 0.198 |
DDR2 |
0.652 | -0.010 | 3 | 0.731 |
MET |
0.652 | -0.094 | 3 | 0.806 |
EPHB1 |
0.652 | -0.149 | 1 | 0.177 |
AXL |
0.651 | -0.142 | 3 | 0.783 |
EPHB3 |
0.650 | -0.149 | -1 | 0.786 |
SRMS |
0.649 | -0.173 | 1 | 0.172 |
EPHB2 |
0.649 | -0.136 | -1 | 0.782 |
FGFR3 |
0.648 | -0.059 | 3 | 0.752 |
BTK |
0.648 | -0.174 | -1 | 0.733 |
ALK |
0.648 | -0.124 | 3 | 0.742 |
TEC |
0.646 | -0.125 | -1 | 0.696 |
MERTK |
0.645 | -0.151 | 3 | 0.781 |
FLT1 |
0.645 | -0.121 | -1 | 0.798 |
FYN |
0.644 | -0.088 | -1 | 0.776 |
BMX |
0.644 | -0.116 | -1 | 0.660 |
INSR |
0.644 | -0.124 | 3 | 0.747 |
FRK |
0.644 | -0.136 | -1 | 0.786 |
FLT4 |
0.644 | -0.126 | 3 | 0.742 |
ERBB2 |
0.644 | -0.145 | 1 | 0.187 |
LTK |
0.643 | -0.133 | 3 | 0.752 |
EPHA1 |
0.641 | -0.140 | 3 | 0.785 |
NTRK2 |
0.641 | -0.172 | 3 | 0.761 |
MATK |
0.640 | -0.091 | -1 | 0.721 |
EPHA7 |
0.640 | -0.130 | 2 | 0.755 |
PTK2B |
0.640 | -0.091 | -1 | 0.759 |
LYN |
0.639 | -0.135 | 3 | 0.728 |
MUSK |
0.639 | -0.111 | 1 | 0.147 |
PTK6 |
0.638 | -0.189 | -1 | 0.712 |
NTRK1 |
0.638 | -0.215 | -1 | 0.796 |
EGFR |
0.638 | -0.112 | 1 | 0.159 |
CK1G3 |
0.637 | -0.075 | -3 | 0.321 |
EPHA3 |
0.637 | -0.141 | 2 | 0.724 |
YANK2 |
0.635 | -0.068 | 2 | 0.420 |
SRC |
0.635 | -0.124 | -1 | 0.782 |
NTRK3 |
0.634 | -0.172 | -1 | 0.742 |
CSK |
0.634 | -0.137 | 2 | 0.763 |
EPHA8 |
0.632 | -0.128 | -1 | 0.759 |
EPHA5 |
0.630 | -0.147 | 2 | 0.729 |
FGFR4 |
0.629 | -0.122 | -1 | 0.738 |
PTK2 |
0.628 | -0.082 | -1 | 0.740 |
SYK |
0.626 | -0.110 | -1 | 0.716 |
IGF1R |
0.623 | -0.137 | 3 | 0.676 |
ERBB4 |
0.623 | -0.101 | 1 | 0.160 |
EPHA2 |
0.620 | -0.142 | -1 | 0.711 |
CK1G2 |
0.617 | -0.078 | -3 | 0.412 |
ZAP70 |
0.616 | -0.080 | -1 | 0.645 |
FES |
0.606 | -0.156 | -1 | 0.659 |