Motif 133 (n=158)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PPC1 | PRR33 | S316 | ochoa | Proline rich 33 | None |
| A7KAX9 | ARHGAP32 | S1401 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8MZF0 | PRR33 | S168 | ochoa | Proline-rich protein 33 | None |
| H0YIS7 | RNASEK-C17orf49 | S147 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O00257 | CBX4 | S434 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O00330 | PDHX | S154 | ochoa | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
| O00499 | BIN1 | S286 | ochoa | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:24755653, ECO:0000269|PubMed:27179792, ECO:0000269|PubMed:28893863, ECO:0000269|PubMed:8782822}. |
| O00512 | BCL9 | S913 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14497 | ARID1A | S711 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14828 | SCAMP3 | Y53 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15117 | FYB1 | S184 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15126 | SCAMP1 | S43 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15357 | INPPL1 | S151 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15357 | INPPL1 | S980 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43294 | TGFB1I1 | S177 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43439 | CBFA2T2 | S43 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O60292 | SIPA1L3 | S1135 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60346 | PHLPP1 | S323 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S450 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60566 | BUB1B | S283 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60885 | BRD4 | S469 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75376 | NCOR1 | S1671 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2395 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S190 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94864 | SUPT7L | S108 | ochoa | STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) | None |
| O94868 | FCHSD2 | S652 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94875 | SORBS2 | S165 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95155 | UBE4B | S23 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| P04049 | RAF1 | S295 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P05387 | RPLP2 | S64 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P06729 | CD2 | S271 | ochoa | T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) | CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. |
| P09874 | PARP1 | S364 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P11274 | BCR | S95 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P12270 | TPR | S640 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12270 | TPR | S1660 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12931 | SRC | S43 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P19878 | NCF2 | S311 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P21917 | DRD4 | S239 | psp | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}. |
| P22681 | CBL | S492 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P27816 | MAP4 | S793 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29353 | SHC1 | S453 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30304 | CDC25A | S185 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31276 | HOXC13 | S234 | ochoa | Homeobox protein Hox-C13 (Homeobox protein Hox-3G) | Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity). {ECO:0000250}. |
| P32519 | ELF1 | S167 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P48634 | PRRC2A | S516 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S837 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49848 | TAF6 | S598 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P50548 | ERF | S131 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P51532 | SMARCA4 | S297 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51610 | HCFC1 | S1497 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P54725 | RAD23A | S102 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P55347 | PKNOX1 | S47 | ochoa | Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) | Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}. |
| P78559 | MAP1A | S996 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98174 | FGD1 | S135 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| P98174 | FGD1 | S227 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q02779 | MAP3K10 | S502 | ochoa | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Q02952 | AKAP12 | S20 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04206 | RELA | S468 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q07889 | SOS1 | S1205 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q0JRZ9 | FCHO2 | S468 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q13029 | PRDM2 | S643 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13285 | NR5A1 | S203 | psp | Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250|UniProtKB:P33242, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:27378692, ECO:0000269|PubMed:28459839}. |
| Q13322 | GRB10 | S134 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13459 | MYO9B | S1267 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13469 | NFATC2 | S56 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13469 | NFATC2 | S363 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13625 | TP53BP2 | S354 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14118 | DAG1 | S814 | ochoa | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}. |
| Q14244 | MAP7 | S348 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q15306 | IRF4 | S177 | psp | Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:29537367, ECO:0000269|PubMed:36662884, ECO:0000269|PubMed:36917008}. |
| Q15428 | SF3A2 | S222 | ochoa | Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310}. |
| Q15569 | TESK1 | S440 | ochoa | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q15751 | HERC1 | S2738 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15759 | MAPK11 | S261 | psp | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Q16666 | IFI16 | S418 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2M3G4 | SHROOM1 | S166 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2QGD7 | ZXDC | S651 | ochoa | Zinc finger protein ZXDC (ZXD-like zinc finger protein) | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}. |
| Q3KQU3 | MAP7D1 | S34 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q58EX7 | PLEKHG4 | S687 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5BKX6 | SLC45A4 | S339 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5SW79 | CEP170 | S1521 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5Y3 | CAMSAP1 | S358 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TGY3 | AHDC1 | S1507 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TZA2 | CROCC | S1486 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VT52 | RPRD2 | S414 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q68DK7 | MSL1 | S167 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IQ23 | PLEKHA7 | S565 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6KC79 | NIPBL | S162 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NV74 | CRACDL | S321 | ochoa | CRACD-like protein | None |
| Q6P1N0 | CC2D1A | S238 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6WKZ4 | RAB11FIP1 | S528 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZNJ1 | NBEAL2 | S1384 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q7Z434 | MAVS | S318 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q86T24 | ZBTB33 | S234 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
| Q8IUW5 | RELL1 | S153 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IVT5 | KSR1 | S257 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IW93 | ARHGEF19 | S101 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S44 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S196 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX12 | CCAR1 | S214 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8IXM2 | BACC1 | S106 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IZL8 | PELP1 | S743 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N8Z6 | DCBLD1 | S672 | psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NC44 | RETREG2 | S131 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NC56 | LEMD2 | S174 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8ND04 | SMG8 | S656 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8WUI4 | HDAC7 | S358 | ochoa|psp | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WV41 | SNX33 | S146 | ochoa | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q8WYP5 | AHCTF1 | S1081 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WZ75 | ROBO4 | S934 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92538 | GBF1 | S1789 | ochoa | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) | Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}. |
| Q92841 | DDX17 | S52 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q93045 | STMN2 | S50 | psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q969G9 | NKD1 | S297 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q96DF8 | ESS2 | S433 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96EP0 | RNF31 | S450 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96FF9 | CDCA5 | S107 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96IZ0 | PAWR | S116 | ochoa | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q96JM3 | CHAMP1 | S161 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S243 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JT2 | SLC45A3 | S422 | ochoa | Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}. |
| Q96L14 | CEP170P1 | S230 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
| Q96MG2 | JSRP1 | S167 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96T58 | SPEN | S1622 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S3138 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BWH6 | RPAP1 | S301 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BYB0 | SHANK3 | S437 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZL4 | PPP1R12C | S498 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C073 | FAM117A | S305 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0D6 | FHDC1 | S570 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9C0K0 | BCL11B | S405 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0W8 | SMG9 | S117 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H201 | EPN3 | S370 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H211 | CDT1 | S390 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H4Z2 | ZNF335 | S991 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H5V7 | IKZF5 | S308 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
| Q9H910 | JPT2 | S45 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9H987 | SYNPO2L | S891 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9H9H4 | VPS37B | S197 | ochoa | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}. |
| Q9HC35 | EML4 | S887 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NPF5 | DMAP1 | S412 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NQ75 | CASS4 | S165 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NR12 | PDLIM7 | S111 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR12 | PDLIM7 | S204 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRR5 | UBQLN4 | S97 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9P242 | NYAP2 | S412 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9UDY2 | TJP2 | S978 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHV7 | MED13 | S553 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UJM3 | ERRFI1 | S126 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9ULX9 | MAFF | S142 | ochoa | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}. |
| Q9UPN3 | MACF1 | S6969 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPZ9 | CILK1 | S584 | ochoa | Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) | Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}. |
| Q9Y2H9 | MAST1 | S1241 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2W2 | WBP11 | S181 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y6X9 | MORC2 | S615 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| Q92785 | DPF2 | S73 | Sugiyama | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q9UM73 | ALK | S1427 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
| Q14524 | SCN5A | S1003 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.000027 | 4.572 |
| R-HSA-8853659 | RET signaling | 0.000007 | 5.161 |
| R-HSA-9842663 | Signaling by LTK | 0.000027 | 4.572 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000014 | 4.866 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.000052 | 4.284 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.000077 | 4.111 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.000148 | 3.829 |
| R-HSA-201556 | Signaling by ALK | 0.000132 | 3.879 |
| R-HSA-4839726 | Chromatin organization | 0.000131 | 3.882 |
| R-HSA-167044 | Signalling to RAS | 0.000172 | 3.764 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.000199 | 3.702 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000272 | 3.565 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.000253 | 3.597 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.000212 | 3.673 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.000253 | 3.597 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000272 | 3.565 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.000334 | 3.476 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.000334 | 3.476 |
| R-HSA-74749 | Signal attenuation | 0.000363 | 3.440 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.000450 | 3.346 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.000423 | 3.374 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.000550 | 3.260 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.000584 | 3.233 |
| R-HSA-177929 | Signaling by EGFR | 0.000593 | 3.227 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.000593 | 3.227 |
| R-HSA-354192 | Integrin signaling | 0.000786 | 3.105 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.000777 | 3.110 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.000929 | 3.032 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.000929 | 3.032 |
| R-HSA-187687 | Signalling to ERKs | 0.001032 | 2.986 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.001453 | 2.838 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.001645 | 2.784 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.001645 | 2.784 |
| R-HSA-9675108 | Nervous system development | 0.001647 | 2.783 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.001944 | 2.711 |
| R-HSA-166520 | Signaling by NTRKs | 0.001870 | 2.728 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.002087 | 2.680 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.002396 | 2.621 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.002390 | 2.622 |
| R-HSA-422475 | Axon guidance | 0.002468 | 2.608 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.002634 | 2.579 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.002634 | 2.579 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.002634 | 2.579 |
| R-HSA-9634597 | GPER1 signaling | 0.002916 | 2.535 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.002928 | 2.533 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.003241 | 2.489 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.003573 | 2.447 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.003926 | 2.406 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.004694 | 2.328 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.005109 | 2.292 |
| R-HSA-190236 | Signaling by FGFR | 0.005866 | 2.232 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.006005 | 2.222 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.006485 | 2.188 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.007094 | 2.149 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.007094 | 2.149 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.007018 | 2.154 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.007094 | 2.149 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.006614 | 2.180 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.007357 | 2.133 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.008062 | 2.094 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.008563 | 2.067 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 0.010317 | 1.986 |
| R-HSA-5673000 | RAF activation | 0.009228 | 2.035 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.010024 | 1.999 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.009846 | 2.007 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.009846 | 2.007 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.008886 | 2.051 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.010487 | 1.979 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.010909 | 1.962 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.011152 | 1.953 |
| R-HSA-8851805 | MET activates RAS signaling | 0.012276 | 1.911 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.012276 | 1.911 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.013766 | 1.861 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.012276 | 1.911 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.013291 | 1.876 |
| R-HSA-6806834 | Signaling by MET | 0.013801 | 1.860 |
| R-HSA-9607240 | FLT3 Signaling | 0.014052 | 1.852 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.014838 | 1.829 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.014838 | 1.829 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.016965 | 1.770 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.016965 | 1.770 |
| R-HSA-171007 | p38MAPK events | 0.016965 | 1.770 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.015329 | 1.814 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.016965 | 1.770 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.015329 | 1.814 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.015329 | 1.814 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.014880 | 1.827 |
| R-HSA-162582 | Signal Transduction | 0.018482 | 1.733 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.018672 | 1.729 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.019133 | 1.718 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.019133 | 1.718 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.019133 | 1.718 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.019133 | 1.718 |
| R-HSA-1640170 | Cell Cycle | 0.020167 | 1.695 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.020448 | 1.689 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.020448 | 1.689 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.024202 | 1.616 |
| R-HSA-210993 | Tie2 Signaling | 0.024202 | 1.616 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.024202 | 1.616 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.022292 | 1.652 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.022007 | 1.657 |
| R-HSA-1500931 | Cell-Cell communication | 0.024756 | 1.606 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.025989 | 1.585 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.028213 | 1.550 |
| R-HSA-3214847 | HATs acetylate histones | 0.028356 | 1.547 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.028356 | 1.547 |
| R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 0.030636 | 1.514 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.034442 | 1.463 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.032471 | 1.489 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.030848 | 1.511 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.031960 | 1.495 |
| R-HSA-73887 | Death Receptor Signaling | 0.034403 | 1.463 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.030003 | 1.523 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.029576 | 1.529 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.032471 | 1.489 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.028919 | 1.539 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.031586 | 1.501 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.034442 | 1.463 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.034442 | 1.463 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.034442 | 1.463 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.034442 | 1.463 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.034442 | 1.463 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.034688 | 1.460 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.034688 | 1.460 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.036963 | 1.432 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.038106 | 1.419 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.039293 | 1.406 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.039293 | 1.406 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.039293 | 1.406 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.039696 | 1.401 |
| R-HSA-5083633 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 0.040639 | 1.391 |
| R-HSA-5083629 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 0.040639 | 1.391 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.041059 | 1.387 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.041059 | 1.387 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.041069 | 1.386 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.046605 | 1.332 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.046263 | 1.335 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.051734 | 1.286 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.048291 | 1.316 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.049145 | 1.309 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.051734 | 1.286 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.043250 | 1.364 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.047721 | 1.321 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.051734 | 1.286 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.051734 | 1.286 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.051734 | 1.286 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.048971 | 1.310 |
| R-HSA-1266738 | Developmental Biology | 0.051524 | 1.288 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.048291 | 1.316 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.050784 | 1.294 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.050784 | 1.294 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.052904 | 1.277 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.052971 | 1.276 |
| R-HSA-2424491 | DAP12 signaling | 0.054371 | 1.265 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.054371 | 1.265 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.057055 | 1.244 |
| R-HSA-186763 | Downstream signal transduction | 0.057055 | 1.244 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.057720 | 1.239 |
| R-HSA-69206 | G1/S Transition | 0.058943 | 1.230 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.070037 | 1.155 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.079636 | 1.099 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.079636 | 1.099 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.079636 | 1.099 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.098540 | 1.006 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 0.098540 | 1.006 |
| R-HSA-112412 | SOS-mediated signalling | 0.098540 | 1.006 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.098540 | 1.006 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 0.107847 | 0.967 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.107847 | 0.967 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.107847 | 0.967 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.065372 | 1.185 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.075195 | 1.124 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.075195 | 1.124 |
| R-HSA-72172 | mRNA Splicing | 0.085068 | 1.070 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.105380 | 0.977 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.105380 | 0.977 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.072169 | 1.142 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.109479 | 0.961 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.073352 | 1.135 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.098540 | 1.006 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.086190 | 1.065 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.092506 | 1.034 |
| R-HSA-191650 | Regulation of gap junction activity | 0.060339 | 1.219 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.100934 | 0.996 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.060339 | 1.219 |
| R-HSA-8849473 | PTK6 Expression | 0.098540 | 1.006 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.112013 | 0.951 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.070037 | 1.155 |
| R-HSA-68877 | Mitotic Prometaphase | 0.071053 | 1.148 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.092461 | 1.034 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.070037 | 1.155 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.098540 | 1.006 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.090654 | 1.043 |
| R-HSA-68882 | Mitotic Anaphase | 0.100431 | 0.998 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.082637 | 1.083 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.068230 | 1.166 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.101771 | 0.992 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.098540 | 1.006 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.062556 | 1.204 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.106722 | 0.972 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.092461 | 1.034 |
| R-HSA-68886 | M Phase | 0.060127 | 1.221 |
| R-HSA-74713 | IRS activation | 0.070037 | 1.155 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.079636 | 1.099 |
| R-HSA-2172127 | DAP12 interactions | 0.102106 | 0.991 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.111741 | 0.952 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.089137 | 1.050 |
| R-HSA-390651 | Dopamine receptors | 0.060339 | 1.219 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.079636 | 1.099 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.098540 | 1.006 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.098540 | 1.006 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.107847 | 0.967 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.089081 | 1.050 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.086227 | 1.064 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.065372 | 1.185 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.086190 | 1.065 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.070037 | 1.155 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.079636 | 1.099 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.107847 | 0.967 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.117058 | 0.932 |
| R-HSA-448706 | Interleukin-1 processing | 0.117058 | 0.932 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.117058 | 0.932 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.117058 | 0.932 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.059783 | 1.223 |
| R-HSA-162587 | HIV Life Cycle | 0.110056 | 0.958 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.107847 | 0.967 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.102106 | 0.991 |
| R-HSA-69242 | S Phase | 0.095428 | 1.020 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.107847 | 0.967 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.117058 | 0.932 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.074066 | 1.130 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.062693 | 1.203 |
| R-HSA-1538133 | G0 and Early G1 | 0.059783 | 1.223 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.077042 | 1.113 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.103044 | 0.987 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.061043 | 1.214 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.074428 | 1.128 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.115370 | 0.938 |
| R-HSA-418990 | Adherens junctions interactions | 0.103119 | 0.987 |
| R-HSA-446728 | Cell junction organization | 0.091403 | 1.039 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.115144 | 0.939 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.059783 | 1.223 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.096467 | 1.016 |
| R-HSA-75153 | Apoptotic execution phase | 0.108683 | 0.964 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.120537 | 0.919 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.120537 | 0.919 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.122086 | 0.913 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.135197 | 0.869 |
| R-HSA-8932505 | DAG1 core M3 glycosylations | 0.135197 | 0.869 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.152966 | 0.815 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.161714 | 0.791 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.195816 | 0.708 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.195816 | 0.708 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.204124 | 0.690 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.220485 | 0.657 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.236511 | 0.626 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.224442 | 0.649 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.212347 | 0.673 |
| R-HSA-3928664 | Ephrin signaling | 0.212347 | 0.673 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.247315 | 0.607 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.236511 | 0.626 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.178941 | 0.747 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.195816 | 0.708 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.178941 | 0.747 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.244401 | 0.612 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.139533 | 0.855 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.234358 | 0.630 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.195816 | 0.708 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.126174 | 0.899 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.126174 | 0.899 |
| R-HSA-192814 | vRNA Synthesis | 0.135197 | 0.869 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.144127 | 0.841 |
| R-HSA-428540 | Activation of RAC1 | 0.144127 | 0.841 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.144127 | 0.841 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.161714 | 0.791 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.178941 | 0.747 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.232052 | 0.634 |
| R-HSA-9843745 | Adipogenesis | 0.196772 | 0.706 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.228540 | 0.641 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.135197 | 0.869 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.228540 | 0.641 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.161714 | 0.791 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.151057 | 0.821 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.126174 | 0.899 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.126174 | 0.899 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.144127 | 0.841 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.236511 | 0.626 |
| R-HSA-194138 | Signaling by VEGF | 0.178586 | 0.748 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.146626 | 0.834 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.168318 | 0.774 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.191529 | 0.718 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.152966 | 0.815 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.170372 | 0.769 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.178941 | 0.747 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.178941 | 0.747 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.163909 | 0.785 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.144127 | 0.841 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.187422 | 0.727 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.209288 | 0.679 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.191528 | 0.718 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.220485 | 0.657 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.244401 | 0.612 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.252210 | 0.598 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.179361 | 0.746 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.129043 | 0.889 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.152966 | 0.815 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.152966 | 0.815 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.152966 | 0.815 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.178941 | 0.747 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.187422 | 0.727 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.157400 | 0.803 |
| R-HSA-2559583 | Cellular Senescence | 0.153476 | 0.814 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.212347 | 0.673 |
| R-HSA-418555 | G alpha (s) signalling events | 0.136491 | 0.865 |
| R-HSA-8953854 | Metabolism of RNA | 0.179718 | 0.745 |
| R-HSA-5689877 | Josephin domain DUBs | 0.126174 | 0.899 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.170372 | 0.769 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.195816 | 0.708 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.212347 | 0.673 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.244401 | 0.612 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.155956 | 0.807 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.235863 | 0.627 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.178941 | 0.747 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.161714 | 0.791 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.194249 | 0.712 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.126174 | 0.899 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.126174 | 0.899 |
| R-HSA-210990 | PECAM1 interactions | 0.135197 | 0.869 |
| R-HSA-392517 | Rap1 signalling | 0.220485 | 0.657 |
| R-HSA-198753 | ERK/MAPK targets | 0.236511 | 0.626 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.244401 | 0.612 |
| R-HSA-168255 | Influenza Infection | 0.151550 | 0.819 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.170372 | 0.769 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.129043 | 0.889 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.164664 | 0.783 |
| R-HSA-186797 | Signaling by PDGF | 0.164664 | 0.783 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.251137 | 0.600 |
| R-HSA-74160 | Gene expression (Transcription) | 0.245354 | 0.610 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.135197 | 0.869 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.220485 | 0.657 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.252210 | 0.598 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.201752 | 0.695 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.161714 | 0.791 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.178941 | 0.747 |
| R-HSA-2028269 | Signaling by Hippo | 0.204124 | 0.690 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.228540 | 0.641 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.143070 | 0.844 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.157400 | 0.803 |
| R-HSA-180292 | GAB1 signalosome | 0.212347 | 0.673 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.246873 | 0.608 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.194249 | 0.712 |
| R-HSA-449147 | Signaling by Interleukins | 0.229306 | 0.640 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.168318 | 0.774 |
| R-HSA-8848021 | Signaling by PTK6 | 0.168318 | 0.774 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.230054 | 0.638 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.208569 | 0.681 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.220485 | 0.657 |
| R-HSA-189200 | Cellular hexose transport | 0.252210 | 0.598 |
| R-HSA-421270 | Cell-cell junction organization | 0.152369 | 0.817 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.161714 | 0.791 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.171986 | 0.765 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.253615 | 0.596 |
| R-HSA-162906 | HIV Infection | 0.254923 | 0.594 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.258787 | 0.587 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.258787 | 0.587 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.258787 | 0.587 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.259160 | 0.586 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.264722 | 0.577 |
| R-HSA-156902 | Peptide chain elongation | 0.266440 | 0.574 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.267588 | 0.573 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.267588 | 0.573 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.267588 | 0.573 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.267588 | 0.573 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.267588 | 0.573 |
| R-HSA-9612973 | Autophagy | 0.270298 | 0.568 |
| R-HSA-9610379 | HCMV Late Events | 0.273092 | 0.564 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.275159 | 0.560 |
| R-HSA-9620244 | Long-term potentiation | 0.275159 | 0.560 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.275159 | 0.560 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.275159 | 0.560 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.277670 | 0.556 |
| R-HSA-8939211 | ESR-mediated signaling | 0.277670 | 0.556 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.277918 | 0.556 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.278511 | 0.555 |
| R-HSA-877300 | Interferon gamma signaling | 0.278687 | 0.555 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.281490 | 0.551 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.281742 | 0.550 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.281742 | 0.550 |
| R-HSA-2262752 | Cellular responses to stress | 0.282495 | 0.549 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.282652 | 0.549 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.282652 | 0.549 |
| R-HSA-525793 | Myogenesis | 0.282652 | 0.549 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.282652 | 0.549 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.282652 | 0.549 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.282652 | 0.549 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.285565 | 0.544 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.285565 | 0.544 |
| R-HSA-109581 | Apoptosis | 0.287102 | 0.542 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.290068 | 0.538 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.290068 | 0.538 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.290068 | 0.538 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.290068 | 0.538 |
| R-HSA-201451 | Signaling by BMP | 0.290068 | 0.538 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.290068 | 0.538 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.297020 | 0.527 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.297020 | 0.527 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.297407 | 0.527 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.297407 | 0.527 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.297407 | 0.527 |
| R-HSA-622312 | Inflammasomes | 0.297407 | 0.527 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.300833 | 0.522 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.300833 | 0.522 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.300833 | 0.522 |
| R-HSA-9824446 | Viral Infection Pathways | 0.304177 | 0.517 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.304642 | 0.516 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.304671 | 0.516 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.304671 | 0.516 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.304671 | 0.516 |
| R-HSA-9609646 | HCMV Infection | 0.307701 | 0.512 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.311861 | 0.506 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.311861 | 0.506 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.311861 | 0.506 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.311861 | 0.506 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.311861 | 0.506 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.312250 | 0.505 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.312250 | 0.505 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.312250 | 0.505 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.312450 | 0.505 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-182971 | EGFR downregulation | 0.318977 | 0.496 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.318977 | 0.496 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.318977 | 0.496 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.318977 | 0.496 |
| R-HSA-5688426 | Deubiquitination | 0.319349 | 0.496 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.322714 | 0.491 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.323628 | 0.490 |
| R-HSA-8931838 | DAG1 glycosylations | 0.326019 | 0.487 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.327410 | 0.485 |
| R-HSA-192823 | Viral mRNA Translation | 0.331187 | 0.480 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.332989 | 0.478 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.332989 | 0.478 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.332989 | 0.478 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.332989 | 0.478 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.332989 | 0.478 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.332989 | 0.478 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.332989 | 0.478 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.332989 | 0.478 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.334958 | 0.475 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.334958 | 0.475 |
| R-HSA-9833110 | RSV-host interactions | 0.338723 | 0.470 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.339888 | 0.469 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.339888 | 0.469 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.339888 | 0.469 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.342482 | 0.465 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.342482 | 0.465 |
| R-HSA-1643685 | Disease | 0.343183 | 0.464 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.346234 | 0.461 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.346715 | 0.460 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.346715 | 0.460 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.346715 | 0.460 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.346715 | 0.460 |
| R-HSA-392518 | Signal amplification | 0.346715 | 0.460 |
| R-HSA-5205647 | Mitophagy | 0.346715 | 0.460 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.349147 | 0.457 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.349979 | 0.456 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.353473 | 0.452 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.353473 | 0.452 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.353473 | 0.452 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.353473 | 0.452 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.353716 | 0.451 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.353716 | 0.451 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.353716 | 0.451 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.357447 | 0.447 |
| R-HSA-69275 | G2/M Transition | 0.357600 | 0.447 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.360161 | 0.444 |
| R-HSA-202403 | TCR signaling | 0.361169 | 0.442 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.361169 | 0.442 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.361169 | 0.442 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.363227 | 0.440 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.363227 | 0.440 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.366780 | 0.436 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.366780 | 0.436 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.366780 | 0.436 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.368591 | 0.433 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.368591 | 0.433 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.372289 | 0.429 |
| R-HSA-8875878 | MET promotes cell motility | 0.373331 | 0.428 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.373331 | 0.428 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.373331 | 0.428 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.379814 | 0.420 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.379814 | 0.420 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.379814 | 0.420 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.383332 | 0.416 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.386231 | 0.413 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.386231 | 0.413 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.386231 | 0.413 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-5260271 | Diseases of Immune System | 0.386231 | 0.413 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.386231 | 0.413 |
| R-HSA-202433 | Generation of second messenger molecules | 0.386231 | 0.413 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.386994 | 0.412 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.390647 | 0.408 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.390647 | 0.408 |
| R-HSA-373760 | L1CAM interactions | 0.390647 | 0.408 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.392582 | 0.406 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.392582 | 0.406 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.392582 | 0.406 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.392582 | 0.406 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.392582 | 0.406 |
| R-HSA-167161 | HIV Transcription Initiation | 0.398868 | 0.399 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.398868 | 0.399 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.398868 | 0.399 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.401549 | 0.396 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.401549 | 0.396 |
| R-HSA-68875 | Mitotic Prophase | 0.405162 | 0.392 |
| R-HSA-913531 | Interferon Signaling | 0.408647 | 0.389 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.411246 | 0.386 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.411246 | 0.386 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.412358 | 0.385 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.412358 | 0.385 |
| R-HSA-5357801 | Programmed Cell Death | 0.413420 | 0.384 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.415940 | 0.381 |
| R-HSA-373752 | Netrin-1 signaling | 0.417340 | 0.380 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.417340 | 0.380 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.417340 | 0.380 |
| R-HSA-69236 | G1 Phase | 0.417340 | 0.380 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.417340 | 0.380 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.423371 | 0.373 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.423371 | 0.373 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.423371 | 0.373 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.426620 | 0.370 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.426620 | 0.370 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.426620 | 0.370 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.429340 | 0.367 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.429340 | 0.367 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.429340 | 0.367 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.429340 | 0.367 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.429340 | 0.367 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.429340 | 0.367 |
| R-HSA-168249 | Innate Immune System | 0.429551 | 0.367 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.434938 | 0.362 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.435247 | 0.361 |
| R-HSA-437239 | Recycling pathway of L1 | 0.435247 | 0.361 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.441094 | 0.355 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.446880 | 0.350 |
| R-HSA-9766229 | Degradation of CDH1 | 0.446880 | 0.350 |
| R-HSA-1474165 | Reproduction | 0.447672 | 0.349 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.452607 | 0.344 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.458275 | 0.339 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.463885 | 0.334 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.463885 | 0.334 |
| R-HSA-212436 | Generic Transcription Pathway | 0.466626 | 0.331 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.469437 | 0.328 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.469437 | 0.328 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.475057 | 0.323 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.478423 | 0.320 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.480370 | 0.318 |
| R-HSA-6807070 | PTEN Regulation | 0.481776 | 0.317 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.481776 | 0.317 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.485116 | 0.314 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.485116 | 0.314 |
| R-HSA-9664407 | Parasite infection | 0.485116 | 0.314 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.485752 | 0.314 |
| R-HSA-75893 | TNF signaling | 0.485752 | 0.314 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.485752 | 0.314 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.485752 | 0.314 |
| R-HSA-72312 | rRNA processing | 0.486146 | 0.313 |
| R-HSA-112399 | IRS-mediated signalling | 0.491079 | 0.309 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.491079 | 0.309 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.495054 | 0.305 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.496351 | 0.304 |
| R-HSA-191859 | snRNP Assembly | 0.501568 | 0.300 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.501568 | 0.300 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.506732 | 0.295 |
| R-HSA-157118 | Signaling by NOTCH | 0.506881 | 0.295 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.511843 | 0.291 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.511843 | 0.291 |
| R-HSA-450294 | MAP kinase activation | 0.511843 | 0.291 |
| R-HSA-5663205 | Infectious disease | 0.512281 | 0.290 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.514566 | 0.289 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.515398 | 0.288 |
| R-HSA-9707616 | Heme signaling | 0.516901 | 0.287 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.516901 | 0.287 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.516901 | 0.287 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.516901 | 0.287 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.521907 | 0.282 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.521907 | 0.282 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.533577 | 0.273 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.536618 | 0.270 |
| R-HSA-1989781 | PPARA activates gene expression | 0.536696 | 0.270 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.542892 | 0.265 |
| R-HSA-199991 | Membrane Trafficking | 0.544012 | 0.264 |
| R-HSA-9711097 | Cellular response to starvation | 0.545968 | 0.263 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.546174 | 0.263 |
| R-HSA-167172 | Transcription of the HIV genome | 0.546174 | 0.263 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.547014 | 0.262 |
| R-HSA-9679506 | SARS-CoV Infections | 0.552928 | 0.257 |
| R-HSA-448424 | Interleukin-17 signaling | 0.555535 | 0.255 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.555535 | 0.255 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.560143 | 0.252 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.560143 | 0.252 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.560143 | 0.252 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.560143 | 0.252 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.560143 | 0.252 |
| R-HSA-3000178 | ECM proteoglycans | 0.560143 | 0.252 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.560143 | 0.252 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.564123 | 0.249 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.564703 | 0.248 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.564703 | 0.248 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.564703 | 0.248 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.564703 | 0.248 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.569217 | 0.245 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.569217 | 0.245 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.569217 | 0.245 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.573683 | 0.241 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.573683 | 0.241 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.575845 | 0.240 |
| R-HSA-380287 | Centrosome maturation | 0.578104 | 0.238 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.578104 | 0.238 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.578104 | 0.238 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.578104 | 0.238 |
| R-HSA-5689603 | UCH proteinases | 0.582480 | 0.235 |
| R-HSA-388396 | GPCR downstream signalling | 0.584917 | 0.233 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.586810 | 0.232 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.590374 | 0.229 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.596047 | 0.225 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.598862 | 0.223 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.598862 | 0.223 |
| R-HSA-109582 | Hemostasis | 0.599141 | 0.222 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.599535 | 0.222 |
| R-HSA-9833482 | PKR-mediated signaling | 0.599535 | 0.222 |
| R-HSA-9658195 | Leishmania infection | 0.605767 | 0.218 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.605767 | 0.218 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.607800 | 0.216 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.607800 | 0.216 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.611870 | 0.213 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.615897 | 0.210 |
| R-HSA-70268 | Pyruvate metabolism | 0.631594 | 0.200 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.631594 | 0.200 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.635418 | 0.197 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.635418 | 0.197 |
| R-HSA-9663891 | Selective autophagy | 0.635418 | 0.197 |
| R-HSA-5617833 | Cilium Assembly | 0.639325 | 0.194 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.641906 | 0.193 |
| R-HSA-195721 | Signaling by WNT | 0.642753 | 0.192 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.642947 | 0.192 |
| R-HSA-202424 | Downstream TCR signaling | 0.642947 | 0.192 |
| R-HSA-73884 | Base Excision Repair | 0.642947 | 0.192 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.644472 | 0.191 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.646654 | 0.189 |
| R-HSA-9609690 | HCMV Early Events | 0.654595 | 0.184 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.657546 | 0.182 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.657546 | 0.182 |
| R-HSA-2029481 | FCGR activation | 0.657546 | 0.182 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.661102 | 0.180 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.664487 | 0.178 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.671550 | 0.173 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.671550 | 0.173 |
| R-HSA-1280218 | Adaptive Immune System | 0.674193 | 0.171 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.674962 | 0.171 |
| R-HSA-70171 | Glycolysis | 0.684986 | 0.164 |
| R-HSA-168256 | Immune System | 0.686826 | 0.163 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.688258 | 0.162 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.691497 | 0.160 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.691497 | 0.160 |
| R-HSA-1483255 | PI Metabolism | 0.691497 | 0.160 |
| R-HSA-372790 | Signaling by GPCR | 0.695081 | 0.158 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.697875 | 0.156 |
| R-HSA-69239 | Synthesis of DNA | 0.710239 | 0.149 |
| R-HSA-211000 | Gene Silencing by RNA | 0.710239 | 0.149 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.713251 | 0.147 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.713251 | 0.147 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.716232 | 0.145 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.729544 | 0.137 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.730679 | 0.136 |
| R-HSA-70326 | Glucose metabolism | 0.744395 | 0.128 |
| R-HSA-5693538 | Homology Directed Repair | 0.747054 | 0.127 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.747054 | 0.127 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.749685 | 0.125 |
| R-HSA-3371556 | Cellular response to heat stress | 0.754866 | 0.122 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.754866 | 0.122 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.759941 | 0.119 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.761148 | 0.119 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.762439 | 0.118 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.769779 | 0.114 |
| R-HSA-69481 | G2/M Checkpoints | 0.772175 | 0.112 |
| R-HSA-5576891 | Cardiac conduction | 0.783789 | 0.106 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.786040 | 0.105 |
| R-HSA-9909396 | Circadian clock | 0.786040 | 0.105 |
| R-HSA-5173105 | O-linked glycosylation | 0.799066 | 0.097 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.807309 | 0.093 |
| R-HSA-1632852 | Macroautophagy | 0.807309 | 0.093 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.815216 | 0.089 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.820934 | 0.086 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.828285 | 0.082 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.830075 | 0.081 |
| R-HSA-69306 | DNA Replication | 0.831847 | 0.080 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.831847 | 0.080 |
| R-HSA-5619102 | SLC transporter disorders | 0.854807 | 0.068 |
| R-HSA-72306 | tRNA processing | 0.860775 | 0.065 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.865090 | 0.063 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.865090 | 0.063 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.865090 | 0.063 |
| R-HSA-6798695 | Neutrophil degranulation | 0.875517 | 0.058 |
| R-HSA-3781865 | Diseases of glycosylation | 0.879805 | 0.056 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.882488 | 0.054 |
| R-HSA-112316 | Neuronal System | 0.885012 | 0.053 |
| R-HSA-983712 | Ion channel transport | 0.885955 | 0.053 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.897585 | 0.047 |
| R-HSA-597592 | Post-translational protein modification | 0.897878 | 0.047 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.898407 | 0.047 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.900521 | 0.046 |
| R-HSA-73894 | DNA Repair | 0.906658 | 0.043 |
| R-HSA-397014 | Muscle contraction | 0.911390 | 0.040 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.911390 | 0.040 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.923921 | 0.034 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.928363 | 0.032 |
| R-HSA-418594 | G alpha (i) signalling events | 0.938157 | 0.028 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.938714 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 0.948777 | 0.023 |
| R-HSA-72766 | Translation | 0.948965 | 0.023 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.957647 | 0.019 |
| R-HSA-1483257 | Phospholipid metabolism | 0.963086 | 0.016 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.972556 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 0.974787 | 0.011 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.977324 | 0.010 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.987225 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.987627 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 0.988877 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.990520 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.990859 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 0.991013 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 0.992924 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.993335 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.998418 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999735 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999926 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.794 | 0.293 | 1 | 0.720 |
PRKD1 |
0.787 | 0.228 | -3 | 0.868 |
CLK3 |
0.786 | 0.188 | 1 | 0.777 |
CDC7 |
0.786 | 0.204 | 1 | 0.832 |
PIM3 |
0.783 | 0.154 | -3 | 0.859 |
PRKD2 |
0.781 | 0.194 | -3 | 0.847 |
COT |
0.781 | 0.044 | 2 | 0.479 |
NDR2 |
0.780 | 0.104 | -3 | 0.867 |
MAPKAPK2 |
0.778 | 0.160 | -3 | 0.800 |
SRPK1 |
0.777 | 0.135 | -3 | 0.806 |
MOS |
0.776 | 0.179 | 1 | 0.818 |
KIS |
0.775 | 0.140 | 1 | 0.652 |
CDKL5 |
0.775 | 0.141 | -3 | 0.833 |
RSK2 |
0.775 | 0.109 | -3 | 0.835 |
GRK1 |
0.775 | 0.122 | -2 | 0.814 |
SKMLCK |
0.775 | 0.151 | -2 | 0.824 |
HIPK2 |
0.774 | 0.181 | 1 | 0.591 |
AURC |
0.773 | 0.124 | -2 | 0.603 |
MAPKAPK3 |
0.772 | 0.141 | -3 | 0.831 |
ICK |
0.771 | 0.161 | -3 | 0.866 |
CHAK2 |
0.771 | 0.184 | -1 | 0.687 |
P90RSK |
0.770 | 0.096 | -3 | 0.824 |
CDKL1 |
0.769 | 0.106 | -3 | 0.831 |
ERK5 |
0.769 | 0.082 | 1 | 0.788 |
DYRK2 |
0.768 | 0.114 | 1 | 0.671 |
PIM1 |
0.768 | 0.118 | -3 | 0.829 |
LATS2 |
0.768 | 0.063 | -5 | 0.669 |
MTOR |
0.767 | 0.032 | 1 | 0.746 |
CLK2 |
0.766 | 0.145 | -3 | 0.806 |
PRPK |
0.766 | 0.009 | -1 | 0.712 |
CAMK2D |
0.766 | 0.060 | -3 | 0.858 |
CAMK2A |
0.765 | 0.095 | 2 | 0.443 |
CAMK1B |
0.764 | 0.046 | -3 | 0.869 |
NLK |
0.764 | 0.027 | 1 | 0.782 |
ATR |
0.764 | 0.065 | 1 | 0.773 |
CDK7 |
0.764 | 0.098 | 1 | 0.654 |
SRPK2 |
0.763 | 0.105 | -3 | 0.740 |
AMPKA1 |
0.763 | 0.104 | -3 | 0.876 |
IKKB |
0.763 | -0.024 | -2 | 0.718 |
NDR1 |
0.763 | 0.030 | -3 | 0.860 |
HIPK1 |
0.763 | 0.148 | 1 | 0.684 |
AMPKA2 |
0.762 | 0.117 | -3 | 0.861 |
RSK4 |
0.762 | 0.100 | -3 | 0.811 |
RSK3 |
0.762 | 0.069 | -3 | 0.815 |
CDK18 |
0.760 | 0.097 | 1 | 0.600 |
DAPK2 |
0.760 | 0.105 | -3 | 0.870 |
NUAK2 |
0.760 | 0.041 | -3 | 0.876 |
PKACB |
0.760 | 0.112 | -2 | 0.608 |
CDK19 |
0.760 | 0.080 | 1 | 0.615 |
RAF1 |
0.759 | -0.014 | 1 | 0.778 |
PRKX |
0.758 | 0.126 | -3 | 0.771 |
TBK1 |
0.758 | -0.042 | 1 | 0.661 |
CAMK2B |
0.758 | 0.046 | 2 | 0.428 |
GRK7 |
0.758 | 0.120 | 1 | 0.764 |
CAMLCK |
0.758 | 0.057 | -2 | 0.798 |
MAK |
0.758 | 0.221 | -2 | 0.824 |
IKKA |
0.757 | 0.025 | -2 | 0.720 |
MARK4 |
0.757 | 0.015 | 4 | 0.796 |
P70S6KB |
0.757 | 0.053 | -3 | 0.834 |
PKACG |
0.757 | 0.046 | -2 | 0.681 |
PKN3 |
0.757 | -0.004 | -3 | 0.843 |
LATS1 |
0.757 | 0.101 | -3 | 0.875 |
CLK1 |
0.756 | 0.103 | -3 | 0.814 |
CDK8 |
0.756 | 0.056 | 1 | 0.646 |
WNK1 |
0.756 | -0.028 | -2 | 0.840 |
NEK6 |
0.755 | 0.006 | -2 | 0.795 |
MNK2 |
0.755 | 0.053 | -2 | 0.728 |
CLK4 |
0.755 | 0.095 | -3 | 0.818 |
BMPR1B |
0.755 | 0.125 | 1 | 0.865 |
NIK |
0.755 | 0.017 | -3 | 0.861 |
PAK1 |
0.755 | 0.042 | -2 | 0.741 |
GCN2 |
0.755 | -0.149 | 2 | 0.443 |
CAMK2G |
0.754 | -0.091 | 2 | 0.454 |
DYRK1A |
0.754 | 0.122 | 1 | 0.685 |
GRK5 |
0.754 | -0.037 | -3 | 0.780 |
PRKD3 |
0.754 | 0.093 | -3 | 0.815 |
TGFBR2 |
0.754 | -0.014 | -2 | 0.744 |
PDHK4 |
0.754 | -0.174 | 1 | 0.785 |
JNK2 |
0.754 | 0.079 | 1 | 0.609 |
TSSK1 |
0.754 | 0.050 | -3 | 0.894 |
PKCD |
0.754 | 0.021 | 2 | 0.436 |
BMPR2 |
0.754 | -0.089 | -2 | 0.835 |
ULK2 |
0.753 | -0.122 | 2 | 0.439 |
DYRK4 |
0.753 | 0.085 | 1 | 0.612 |
MST4 |
0.753 | -0.011 | 2 | 0.492 |
IKKE |
0.753 | -0.065 | 1 | 0.654 |
SRPK3 |
0.753 | 0.065 | -3 | 0.764 |
HIPK3 |
0.753 | 0.124 | 1 | 0.662 |
PKN2 |
0.752 | -0.017 | -3 | 0.853 |
P38B |
0.752 | 0.101 | 1 | 0.629 |
MNK1 |
0.751 | 0.040 | -2 | 0.738 |
QSK |
0.751 | 0.059 | 4 | 0.775 |
MSK1 |
0.751 | 0.057 | -3 | 0.795 |
MLK2 |
0.751 | 0.025 | 2 | 0.462 |
TSSK2 |
0.751 | 0.010 | -5 | 0.774 |
TGFBR1 |
0.751 | 0.066 | -2 | 0.766 |
RIPK3 |
0.750 | -0.087 | 3 | 0.574 |
PKG2 |
0.750 | 0.057 | -2 | 0.610 |
MASTL |
0.750 | -0.089 | -2 | 0.788 |
PAK6 |
0.750 | 0.036 | -2 | 0.652 |
DSTYK |
0.750 | -0.106 | 2 | 0.478 |
BRSK1 |
0.750 | 0.031 | -3 | 0.832 |
PAK3 |
0.750 | 0.013 | -2 | 0.732 |
PKCB |
0.749 | 0.013 | 2 | 0.391 |
MPSK1 |
0.749 | 0.181 | 1 | 0.719 |
NIM1 |
0.749 | -0.045 | 3 | 0.625 |
MSK2 |
0.749 | 0.024 | -3 | 0.792 |
MELK |
0.748 | 0.020 | -3 | 0.847 |
PKCA |
0.748 | 0.014 | 2 | 0.394 |
PIM2 |
0.748 | 0.091 | -3 | 0.807 |
PDHK1 |
0.747 | -0.140 | 1 | 0.751 |
CDK1 |
0.747 | 0.053 | 1 | 0.643 |
AKT2 |
0.747 | 0.084 | -3 | 0.770 |
HUNK |
0.747 | -0.108 | 2 | 0.430 |
P38A |
0.747 | 0.080 | 1 | 0.686 |
ALK4 |
0.747 | 0.043 | -2 | 0.790 |
AURB |
0.747 | 0.042 | -2 | 0.596 |
GRK6 |
0.746 | -0.042 | 1 | 0.824 |
ERK1 |
0.746 | 0.061 | 1 | 0.616 |
CDK5 |
0.746 | 0.045 | 1 | 0.673 |
DYRK1B |
0.746 | 0.086 | 1 | 0.637 |
SGK3 |
0.746 | 0.056 | -3 | 0.819 |
PHKG1 |
0.745 | 0.008 | -3 | 0.854 |
BRSK2 |
0.745 | 0.001 | -3 | 0.847 |
JNK3 |
0.745 | 0.044 | 1 | 0.632 |
CDK13 |
0.745 | 0.029 | 1 | 0.626 |
CDK17 |
0.745 | 0.052 | 1 | 0.560 |
NUAK1 |
0.744 | 0.015 | -3 | 0.835 |
ULK1 |
0.744 | -0.148 | -3 | 0.743 |
DCAMKL1 |
0.744 | 0.060 | -3 | 0.843 |
FAM20C |
0.744 | -0.038 | 2 | 0.316 |
CAMK4 |
0.744 | -0.038 | -3 | 0.847 |
PKCG |
0.744 | -0.021 | 2 | 0.384 |
DLK |
0.743 | -0.080 | 1 | 0.797 |
MOK |
0.743 | 0.169 | 1 | 0.702 |
SIK |
0.743 | 0.039 | -3 | 0.807 |
CDK14 |
0.742 | 0.052 | 1 | 0.638 |
PKCZ |
0.742 | -0.000 | 2 | 0.435 |
NEK7 |
0.742 | -0.141 | -3 | 0.784 |
MLK3 |
0.742 | -0.036 | 2 | 0.386 |
MYLK4 |
0.742 | 0.022 | -2 | 0.717 |
PKACA |
0.742 | 0.077 | -2 | 0.558 |
MLK1 |
0.742 | -0.150 | 2 | 0.423 |
PASK |
0.742 | 0.086 | -3 | 0.873 |
MARK3 |
0.742 | 0.022 | 4 | 0.727 |
BCKDK |
0.741 | -0.140 | -1 | 0.622 |
P38G |
0.741 | 0.047 | 1 | 0.557 |
NEK9 |
0.740 | -0.112 | 2 | 0.466 |
IRE1 |
0.740 | -0.084 | 1 | 0.703 |
CDK9 |
0.740 | 0.015 | 1 | 0.633 |
CDK10 |
0.740 | 0.055 | 1 | 0.626 |
CHK1 |
0.740 | 0.022 | -3 | 0.843 |
DYRK3 |
0.740 | 0.074 | 1 | 0.678 |
P38D |
0.740 | 0.080 | 1 | 0.553 |
CDK3 |
0.739 | 0.048 | 1 | 0.578 |
BUB1 |
0.739 | 0.217 | -5 | 0.725 |
CDK12 |
0.739 | 0.027 | 1 | 0.601 |
GRK4 |
0.739 | -0.107 | -2 | 0.807 |
RIPK1 |
0.739 | -0.148 | 1 | 0.736 |
PAK2 |
0.738 | -0.021 | -2 | 0.724 |
TTBK2 |
0.738 | -0.141 | 2 | 0.372 |
ACVR2B |
0.738 | 0.050 | -2 | 0.747 |
GSK3A |
0.738 | 0.098 | 4 | 0.603 |
CHAK1 |
0.738 | -0.006 | 2 | 0.491 |
QIK |
0.738 | -0.061 | -3 | 0.850 |
GSK3B |
0.737 | 0.080 | 4 | 0.600 |
SMG1 |
0.737 | -0.005 | 1 | 0.721 |
CDK16 |
0.736 | 0.052 | 1 | 0.570 |
DNAPK |
0.736 | 0.011 | 1 | 0.644 |
WNK3 |
0.736 | -0.232 | 1 | 0.726 |
PLK1 |
0.736 | -0.076 | -2 | 0.736 |
VRK2 |
0.736 | -0.064 | 1 | 0.794 |
MAPKAPK5 |
0.736 | 0.002 | -3 | 0.759 |
PKCH |
0.736 | -0.050 | 2 | 0.374 |
ATM |
0.736 | -0.043 | 1 | 0.716 |
GRK2 |
0.735 | 0.007 | -2 | 0.697 |
MARK2 |
0.735 | -0.020 | 4 | 0.698 |
ACVR2A |
0.734 | 0.009 | -2 | 0.730 |
PKR |
0.734 | -0.073 | 1 | 0.748 |
LKB1 |
0.734 | 0.210 | -3 | 0.787 |
TLK2 |
0.733 | -0.003 | 1 | 0.711 |
MEK1 |
0.733 | -0.096 | 2 | 0.477 |
AURA |
0.733 | 0.003 | -2 | 0.573 |
ANKRD3 |
0.733 | -0.172 | 1 | 0.781 |
CK1E |
0.733 | -0.009 | -3 | 0.500 |
DRAK1 |
0.733 | -0.019 | 1 | 0.834 |
SSTK |
0.733 | -0.003 | 4 | 0.760 |
ALK2 |
0.732 | -0.007 | -2 | 0.779 |
YSK4 |
0.732 | -0.092 | 1 | 0.719 |
NEK2 |
0.732 | -0.060 | 2 | 0.472 |
CAMK1D |
0.731 | 0.052 | -3 | 0.764 |
AKT1 |
0.731 | 0.053 | -3 | 0.790 |
P70S6K |
0.731 | 0.021 | -3 | 0.767 |
DCAMKL2 |
0.731 | -0.009 | -3 | 0.859 |
ERK7 |
0.730 | -0.005 | 2 | 0.292 |
IRE2 |
0.730 | -0.105 | 2 | 0.414 |
PRP4 |
0.730 | 0.015 | -3 | 0.683 |
CAMK1G |
0.730 | -0.024 | -3 | 0.810 |
MARK1 |
0.730 | -0.034 | 4 | 0.741 |
SNRK |
0.729 | -0.126 | 2 | 0.379 |
ERK2 |
0.729 | -0.011 | 1 | 0.651 |
MST3 |
0.728 | 0.001 | 2 | 0.465 |
MLK4 |
0.728 | -0.110 | 2 | 0.365 |
AKT3 |
0.728 | 0.079 | -3 | 0.725 |
PAK5 |
0.728 | 0.008 | -2 | 0.601 |
SBK |
0.727 | 0.099 | -3 | 0.682 |
BMPR1A |
0.727 | 0.037 | 1 | 0.832 |
PAK4 |
0.726 | 0.005 | -2 | 0.609 |
PLK4 |
0.726 | -0.117 | 2 | 0.334 |
DAPK3 |
0.726 | 0.056 | -3 | 0.843 |
SGK1 |
0.726 | 0.077 | -3 | 0.701 |
PKCT |
0.726 | -0.035 | 2 | 0.387 |
PKCE |
0.725 | 0.002 | 2 | 0.379 |
JNK1 |
0.725 | 0.026 | 1 | 0.606 |
CK2A2 |
0.725 | 0.033 | 1 | 0.770 |
TAO3 |
0.725 | 0.007 | 1 | 0.740 |
CDK2 |
0.725 | -0.046 | 1 | 0.718 |
CK1D |
0.724 | 0.004 | -3 | 0.453 |
PERK |
0.724 | -0.107 | -2 | 0.791 |
PLK3 |
0.723 | -0.121 | 2 | 0.420 |
SMMLCK |
0.723 | -0.015 | -3 | 0.843 |
NEK5 |
0.723 | -0.038 | 1 | 0.748 |
PBK |
0.723 | 0.109 | 1 | 0.735 |
CAMKK2 |
0.723 | 0.064 | -2 | 0.742 |
DAPK1 |
0.722 | 0.044 | -3 | 0.827 |
WNK4 |
0.722 | -0.116 | -2 | 0.834 |
IRAK4 |
0.722 | -0.096 | 1 | 0.699 |
BRAF |
0.722 | -0.075 | -4 | 0.731 |
GRK3 |
0.722 | -0.008 | -2 | 0.662 |
PKCI |
0.722 | -0.041 | 2 | 0.402 |
CHK2 |
0.722 | 0.060 | -3 | 0.732 |
ROCK2 |
0.721 | 0.079 | -3 | 0.833 |
MEK5 |
0.721 | -0.170 | 2 | 0.459 |
GCK |
0.719 | 0.054 | 1 | 0.766 |
CDK4 |
0.719 | 0.019 | 1 | 0.587 |
CK1A2 |
0.718 | -0.020 | -3 | 0.458 |
CAMK1A |
0.718 | 0.048 | -3 | 0.743 |
PHKG2 |
0.718 | -0.071 | -3 | 0.844 |
CK2A1 |
0.717 | 0.034 | 1 | 0.763 |
CK1G1 |
0.717 | -0.050 | -3 | 0.474 |
ZAK |
0.717 | -0.147 | 1 | 0.725 |
GAK |
0.717 | -0.020 | 1 | 0.815 |
PKN1 |
0.717 | -0.006 | -3 | 0.795 |
CDK6 |
0.716 | 0.007 | 1 | 0.609 |
MEKK1 |
0.716 | -0.163 | 1 | 0.727 |
CAMKK1 |
0.716 | -0.048 | -2 | 0.743 |
NEK11 |
0.716 | -0.090 | 1 | 0.735 |
MEKK6 |
0.715 | -0.037 | 1 | 0.739 |
MAP3K15 |
0.715 | -0.004 | 1 | 0.702 |
MEKK2 |
0.715 | -0.151 | 2 | 0.435 |
TLK1 |
0.715 | -0.101 | -2 | 0.784 |
PDK1 |
0.715 | -0.036 | 1 | 0.702 |
MRCKB |
0.714 | 0.039 | -3 | 0.797 |
MRCKA |
0.714 | 0.038 | -3 | 0.807 |
TNIK |
0.714 | 0.036 | 3 | 0.736 |
HPK1 |
0.714 | 0.024 | 1 | 0.745 |
PINK1 |
0.713 | -0.104 | 1 | 0.742 |
HRI |
0.712 | -0.191 | -2 | 0.786 |
MEKK3 |
0.712 | -0.222 | 1 | 0.760 |
NEK4 |
0.711 | -0.023 | 1 | 0.704 |
KHS1 |
0.711 | 0.052 | 1 | 0.705 |
TAO2 |
0.711 | -0.083 | 2 | 0.489 |
LOK |
0.710 | 0.001 | -2 | 0.720 |
HGK |
0.710 | -0.007 | 3 | 0.720 |
TTBK1 |
0.710 | -0.165 | 2 | 0.326 |
DMPK1 |
0.710 | 0.062 | -3 | 0.827 |
CRIK |
0.710 | 0.079 | -3 | 0.794 |
KHS2 |
0.709 | 0.040 | 1 | 0.731 |
NEK1 |
0.709 | 0.013 | 1 | 0.713 |
MINK |
0.708 | -0.027 | 1 | 0.722 |
LRRK2 |
0.708 | -0.082 | 2 | 0.482 |
PDHK3_TYR |
0.707 | 0.232 | 4 | 0.873 |
EEF2K |
0.707 | -0.076 | 3 | 0.669 |
NEK8 |
0.706 | -0.158 | 2 | 0.451 |
PKG1 |
0.705 | -0.000 | -2 | 0.519 |
SLK |
0.705 | -0.019 | -2 | 0.681 |
MST2 |
0.705 | -0.092 | 1 | 0.756 |
VRK1 |
0.704 | -0.115 | 2 | 0.461 |
TAK1 |
0.703 | -0.104 | 1 | 0.747 |
STK33 |
0.703 | -0.119 | 2 | 0.327 |
CK1A |
0.703 | 0.017 | -3 | 0.361 |
IRAK1 |
0.703 | -0.241 | -1 | 0.596 |
PLK2 |
0.702 | -0.082 | -3 | 0.658 |
ROCK1 |
0.701 | 0.031 | -3 | 0.803 |
HASPIN |
0.699 | -0.012 | -1 | 0.585 |
LIMK2_TYR |
0.699 | 0.169 | -3 | 0.864 |
YANK3 |
0.699 | -0.058 | 2 | 0.214 |
TESK1_TYR |
0.698 | 0.114 | 3 | 0.748 |
MST1 |
0.696 | -0.088 | 1 | 0.727 |
MAP2K4_TYR |
0.696 | 0.124 | -1 | 0.704 |
YSK1 |
0.696 | -0.090 | 2 | 0.451 |
PDHK4_TYR |
0.696 | 0.074 | 2 | 0.515 |
BIKE |
0.695 | 0.030 | 1 | 0.711 |
MEK2 |
0.694 | -0.152 | 2 | 0.465 |
PKMYT1_TYR |
0.693 | 0.047 | 3 | 0.708 |
MAP2K6_TYR |
0.692 | 0.029 | -1 | 0.706 |
OSR1 |
0.691 | -0.053 | 2 | 0.451 |
NEK3 |
0.690 | -0.112 | 1 | 0.668 |
ASK1 |
0.688 | -0.066 | 1 | 0.690 |
MYO3B |
0.688 | -0.022 | 2 | 0.488 |
BMPR2_TYR |
0.687 | -0.022 | -1 | 0.694 |
MAP2K7_TYR |
0.687 | -0.116 | 2 | 0.490 |
TXK |
0.687 | 0.083 | 1 | 0.868 |
AAK1 |
0.686 | 0.066 | 1 | 0.623 |
TNK2 |
0.686 | 0.064 | 3 | 0.605 |
EPHB4 |
0.686 | 0.015 | -1 | 0.644 |
EPHA6 |
0.686 | -0.021 | -1 | 0.682 |
PDHK1_TYR |
0.686 | -0.026 | -1 | 0.706 |
TTK |
0.686 | -0.069 | -2 | 0.763 |
RIPK2 |
0.685 | -0.245 | 1 | 0.669 |
ABL2 |
0.684 | 0.058 | -1 | 0.653 |
TAO1 |
0.684 | -0.074 | 1 | 0.648 |
PINK1_TYR |
0.681 | -0.159 | 1 | 0.778 |
ABL1 |
0.680 | 0.033 | -1 | 0.651 |
LIMK1_TYR |
0.679 | -0.086 | 2 | 0.498 |
FGR |
0.678 | -0.011 | 1 | 0.830 |
RET |
0.678 | -0.062 | 1 | 0.721 |
ROS1 |
0.677 | -0.032 | 3 | 0.604 |
TYRO3 |
0.677 | -0.074 | 3 | 0.640 |
MYO3A |
0.676 | -0.093 | 1 | 0.693 |
ALPHAK3 |
0.676 | -0.086 | -1 | 0.612 |
SRMS |
0.674 | -0.038 | 1 | 0.833 |
EPHA4 |
0.674 | -0.052 | 2 | 0.429 |
JAK2 |
0.674 | -0.038 | 1 | 0.706 |
TNK1 |
0.674 | -0.001 | 3 | 0.635 |
JAK1 |
0.673 | 0.061 | 1 | 0.666 |
MST1R |
0.673 | -0.096 | 3 | 0.658 |
DDR1 |
0.673 | -0.106 | 4 | 0.786 |
NEK10_TYR |
0.673 | 0.031 | 1 | 0.602 |
ITK |
0.673 | -0.040 | -1 | 0.637 |
CSF1R |
0.673 | -0.059 | 3 | 0.636 |
LCK |
0.673 | 0.022 | -1 | 0.686 |
TYK2 |
0.672 | -0.098 | 1 | 0.707 |
TNNI3K_TYR |
0.672 | 0.022 | 1 | 0.718 |
PTK2B |
0.672 | 0.020 | -1 | 0.640 |
MERTK |
0.672 | -0.033 | 3 | 0.630 |
YES1 |
0.671 | -0.072 | -1 | 0.698 |
FER |
0.670 | -0.087 | 1 | 0.832 |
EPHB3 |
0.670 | -0.062 | -1 | 0.633 |
EPHB1 |
0.670 | -0.062 | 1 | 0.822 |
HCK |
0.669 | -0.060 | -1 | 0.676 |
AXL |
0.669 | -0.064 | 3 | 0.618 |
BMX |
0.668 | -0.031 | -1 | 0.580 |
BLK |
0.668 | 0.002 | -1 | 0.681 |
EPHB2 |
0.668 | -0.064 | -1 | 0.622 |
JAK3 |
0.667 | -0.102 | 1 | 0.722 |
STLK3 |
0.667 | -0.151 | 1 | 0.684 |
INSRR |
0.666 | -0.103 | 3 | 0.566 |
FYN |
0.663 | -0.037 | -1 | 0.676 |
EPHA7 |
0.663 | -0.072 | 2 | 0.433 |
MET |
0.662 | -0.062 | 3 | 0.637 |
PDGFRB |
0.662 | -0.138 | 3 | 0.635 |
PTK6 |
0.662 | -0.083 | -1 | 0.596 |
DDR2 |
0.662 | -0.007 | 3 | 0.543 |
YANK2 |
0.661 | -0.082 | 2 | 0.218 |
EPHA3 |
0.660 | -0.108 | 2 | 0.413 |
KIT |
0.660 | -0.119 | 3 | 0.630 |
FGFR2 |
0.660 | -0.172 | 3 | 0.621 |
EPHA1 |
0.660 | -0.089 | 3 | 0.616 |
KDR |
0.660 | -0.124 | 3 | 0.589 |
ALK |
0.660 | -0.075 | 3 | 0.531 |
TEC |
0.659 | -0.095 | -1 | 0.587 |
PTK2 |
0.659 | -0.011 | -1 | 0.619 |
LTK |
0.658 | -0.103 | 3 | 0.565 |
BTK |
0.657 | -0.168 | -1 | 0.612 |
PDGFRA |
0.656 | -0.155 | 3 | 0.632 |
TEK |
0.656 | -0.178 | 3 | 0.560 |
FGFR1 |
0.656 | -0.162 | 3 | 0.596 |
NTRK1 |
0.655 | -0.151 | -1 | 0.639 |
NTRK3 |
0.655 | -0.075 | -1 | 0.610 |
WEE1_TYR |
0.654 | -0.129 | -1 | 0.597 |
CK1G3 |
0.653 | -0.075 | -3 | 0.314 |
EPHA5 |
0.653 | -0.108 | 2 | 0.414 |
FLT3 |
0.653 | -0.201 | 3 | 0.634 |
SRC |
0.652 | -0.079 | -1 | 0.672 |
INSR |
0.652 | -0.127 | 3 | 0.557 |
EPHA8 |
0.652 | -0.088 | -1 | 0.623 |
LYN |
0.652 | -0.104 | 3 | 0.550 |
FRK |
0.651 | -0.126 | -1 | 0.672 |
ERBB2 |
0.649 | -0.162 | 1 | 0.715 |
SYK |
0.649 | -0.035 | -1 | 0.607 |
MATK |
0.648 | -0.110 | -1 | 0.588 |
FGFR3 |
0.647 | -0.184 | 3 | 0.588 |
FLT1 |
0.647 | -0.171 | -1 | 0.635 |
CSK |
0.647 | -0.123 | 2 | 0.430 |
NTRK2 |
0.647 | -0.184 | 3 | 0.571 |
EGFR |
0.645 | -0.108 | 1 | 0.639 |
FLT4 |
0.642 | -0.221 | 3 | 0.581 |
CK1G2 |
0.642 | -0.060 | -3 | 0.399 |
EPHA2 |
0.641 | -0.107 | -1 | 0.582 |
MUSK |
0.638 | -0.123 | 1 | 0.630 |
FGFR4 |
0.638 | -0.135 | -1 | 0.597 |
IGF1R |
0.637 | -0.132 | 3 | 0.490 |
ERBB4 |
0.636 | -0.083 | 1 | 0.685 |
ZAP70 |
0.635 | -0.017 | -1 | 0.558 |
FES |
0.632 | -0.103 | -1 | 0.568 |