Motif 131 (n=44)

Position-wise Probabilities

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uniprot genes site source protein function
O14641 DVL2 S614 ochoa Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}.
O43314 PPIP5K2 S788 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
P0DPH7 TUBA3C T225 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T225 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P16389 KCNA2 S440 ochoa Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2) Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11211111, PubMed:19912772, PubMed:23769686, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20220134, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). {ECO:0000250|UniProtKB:P63141, ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:32833227, ECO:0000269|PubMed:35439054, ECO:0000269|PubMed:37883018, ECO:0000269|PubMed:8495559, ECO:0000305}.
P30414 NKTR S887 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P35226 BMI1 S251 ochoa Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332). {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:27827373}.
P35348 ADRA1A S401 psp Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
P46459 NSF S437 ochoa Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}.
P47756 CAPZB S226 psp F-actin-capping protein subunit beta (CapZ beta) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}.
P51531 SMARCA2 S1408 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P52594 AGFG1 S293 ochoa Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.
P68363 TUBA1B T225 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A T225 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q02487 DSC2 S824 ochoa Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}.
Q08495 DMTN S269 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q14574 DSC3 S819 ochoa Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}.
Q15746 MYLK S947 ochoa|psp Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q17R98 ZNF827 S961 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q5R372 RABGAP1L S71 ochoa Rab GTPase-activating protein 1-like GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
Q6PEY2 TUBA3E T225 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6ZVD7 STOX1 S392 ochoa Storkhead-box protein 1 (Winged-helix domain-containing protein) Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}.
Q71U36 TUBA1A T225 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q86UE4 MTDH S251 ochoa Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
Q8IVL0 NAV3 S1670 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8N0Z3 SPICE1 T230 ochoa Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}.
Q8N264 ARHGAP24 S626 ochoa Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
Q8NEF9 SRFBP1 S140 ochoa Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEY1 NAV1 S1182 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8WUY3 PRUNE2 T1620 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WWK9 CKAP2 S304 ochoa Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
Q92622 RUBCN S197 ochoa Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}.
Q96DF8 ESS2 S391 ochoa Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}.
Q9BQE3 TUBA1C T225 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9NQW6 ANLN S274 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NY61 AATF S61 ochoa Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}.
Q9NY65 TUBA8 T225 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9P0L0 VAPA S214 ochoa Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}.
Q9ULL8 SHROOM4 S785 ochoa Protein Shroom4 (Second homolog of apical protein) Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}.
Q9UPV9 TRAK1 S535 ochoa Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}.
R4GMX3 COMMD3-BMI1 S394 ochoa Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000256|ARBA:ARBA00045235}.
Q06124 PTPN11 S134 Sugiyama Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}.
P17948 FLT1 S1205 Sugiyama Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}.
Q9BX40 LSM14B T343 Sugiyama Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}.
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reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 4.329870e-15 14.364
R-HSA-190872 Transport of connexons to the plasma membrane 6.217249e-15 14.206
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.210143e-14 13.917
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 5.129230e-14 13.290
R-HSA-9619483 Activation of AMPK downstream of NMDARs 1.382228e-13 12.859
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 2.701173e-13 12.568
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.138600e-13 12.503
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 4.097833e-13 12.387
R-HSA-190861 Gap junction assembly 6.087353e-13 12.216
R-HSA-6807878 COPI-mediated anterograde transport 8.719692e-13 12.059
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.650791e-12 11.782
R-HSA-9646399 Aggrephagy 1.791345e-12 11.747
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 2.489120e-12 11.604
R-HSA-190828 Gap junction trafficking 3.977596e-12 11.400
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 6.188827e-12 11.208
R-HSA-437239 Recycling pathway of L1 6.188827e-12 11.208
R-HSA-157858 Gap junction trafficking and regulation 8.199441e-12 11.086
R-HSA-8856688 Golgi-to-ER retrograde transport 2.045919e-11 10.689
R-HSA-983189 Kinesins 3.283152e-11 10.484
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.352574e-11 10.475
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 4.121758e-11 10.385
R-HSA-199977 ER to Golgi Anterograde Transport 5.850287e-11 10.233
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.063327e-10 9.973
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.293028e-10 9.888
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.470933e-10 9.607
R-HSA-9833482 PKR-mediated signaling 2.470933e-10 9.607
R-HSA-2132295 MHC class II antigen presentation 2.903302e-10 9.537
R-HSA-390466 Chaperonin-mediated protein folding 4.869435e-10 9.313
R-HSA-438064 Post NMDA receptor activation events 4.869435e-10 9.313
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.278628e-10 9.277
R-HSA-9663891 Selective autophagy 5.278628e-10 9.277
R-HSA-391251 Protein folding 7.804422e-10 9.108
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.832733e-10 9.054
R-HSA-948021 Transport to the Golgi and subsequent modification 9.631580e-10 9.016
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.728174e-09 8.762
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.934585e-09 8.532
R-HSA-373760 L1CAM interactions 5.106818e-09 8.292
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 5.866279e-09 8.232
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.830643e-09 8.166
R-HSA-5620924 Intraflagellar transport 1.915152e-08 7.718
R-HSA-1632852 Macroautophagy 2.285096e-08 7.641
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.699662e-08 7.569
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.040991e-08 7.517
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.369079e-08 7.360
R-HSA-9612973 Autophagy 4.771220e-08 7.321
R-HSA-2467813 Separation of Sister Chromatids 6.715804e-08 7.173
R-HSA-69275 G2/M Transition 1.653434e-07 6.782
R-HSA-453274 Mitotic G2-G2/M phases 1.779059e-07 6.750
R-HSA-5617833 Cilium Assembly 1.912798e-07 6.718
R-HSA-68877 Mitotic Prometaphase 2.129574e-07 6.672
R-HSA-9609690 HCMV Early Events 2.367119e-07 6.626
R-HSA-199991 Membrane Trafficking 4.535583e-07 6.343
R-HSA-68882 Mitotic Anaphase 4.761558e-07 6.322
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.914449e-07 6.309
R-HSA-446203 Asparagine N-linked glycosylation 6.228131e-07 6.206
R-HSA-112315 Transmission across Chemical Synapses 7.136478e-07 6.147
R-HSA-5610787 Hedgehog 'off' state 1.027031e-06 5.988
R-HSA-9609646 HCMV Infection 1.295805e-06 5.887
R-HSA-112316 Neuronal System 1.512853e-06 5.820
R-HSA-913531 Interferon Signaling 2.721548e-06 5.565
R-HSA-5653656 Vesicle-mediated transport 4.226242e-06 5.374
R-HSA-5358351 Signaling by Hedgehog 6.900526e-06 5.161
R-HSA-1852241 Organelle biogenesis and maintenance 7.011284e-06 5.154
R-HSA-68886 M Phase 2.373638e-05 4.625
R-HSA-422475 Axon guidance 3.953456e-05 4.403
R-HSA-9675108 Nervous system development 6.438864e-05 4.191
R-HSA-162582 Signal Transduction 7.098732e-05 4.149
R-HSA-109582 Hemostasis 1.104550e-04 3.957
R-HSA-69278 Cell Cycle, Mitotic 3.187623e-04 3.497
R-HSA-390696 Adrenoceptors 5.154573e-04 3.288
R-HSA-2262752 Cellular responses to stress 8.435810e-04 3.074
R-HSA-1280218 Adaptive Immune System 1.034082e-03 2.985
R-HSA-1280215 Cytokine Signaling in Immune system 1.258836e-03 2.900
R-HSA-1640170 Cell Cycle 1.311922e-03 2.882
R-HSA-8953897 Cellular responses to stimuli 2.013923e-03 2.696
R-HSA-1266738 Developmental Biology 4.099344e-03 2.387
R-HSA-9008059 Interleukin-37 signaling 5.265376e-03 2.279
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 6.144555e-03 2.212
R-HSA-9824446 Viral Infection Pathways 6.252849e-03 2.204
R-HSA-6809371 Formation of the cornified envelope 8.167129e-03 2.088
R-HSA-597592 Post-translational protein modification 9.287451e-03 2.032
R-HSA-375280 Amine ligand-binding receptors 1.065887e-02 1.972
R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 1.185391e-02 1.926
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1.479582e-02 1.830
R-HSA-8865999 MET activates PTPN11 1.479582e-02 1.830
R-HSA-9645135 STAT5 Activation 2.647794e-02 1.577
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.917326e-02 1.717
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.917326e-02 1.717
R-HSA-8854518 AURKA Activation by TPX2 2.071080e-02 1.684
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 2.449076e-02 1.611
R-HSA-380287 Centrosome maturation 2.561893e-02 1.591
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 2.357019e-02 1.628
R-HSA-9927353 Co-inhibition by BTLA 2.065394e-02 1.685
R-HSA-194313 VEGF ligand-receptor interactions 2.357019e-02 1.628
R-HSA-416482 G alpha (12/13) signalling events 2.735029e-02 1.563
R-HSA-5663205 Infectious disease 2.748820e-02 1.561
R-HSA-418886 Netrin mediated repulsion signals 2.937722e-02 1.532
R-HSA-6805567 Keratinization 2.992960e-02 1.524
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 3.095034e-02 1.509
R-HSA-201688 WNT mediated activation of DVL 3.515042e-02 1.454
R-HSA-112411 MAPK1 (ERK2) activation 3.515042e-02 1.454
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 3.537368e-02 1.451
R-HSA-8878171 Transcriptional regulation by RUNX1 3.705207e-02 1.431
R-HSA-110056 MAPK3 (ERK1) activation 3.802440e-02 1.420
R-HSA-2586552 Signaling by Leptin 3.802440e-02 1.420
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 7.186509e-02 1.143
R-HSA-5099900 WNT5A-dependent internalization of FZD4 5.790887e-02 1.237
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 7.186509e-02 1.143
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 5.790887e-02 1.237
R-HSA-9664420 Killing mechanisms 5.790887e-02 1.237
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 4.943673e-02 1.306
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 6.071646e-02 1.217
R-HSA-180292 GAB1 signalosome 6.630707e-02 1.178
R-HSA-5654710 PI-3K cascade:FGFR3 6.909014e-02 1.161
R-HSA-5654720 PI-3K cascade:FGFR4 7.186509e-02 1.143
R-HSA-5654689 PI-3K cascade:FGFR1 8.014144e-02 1.096
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 5.509307e-02 1.259
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 6.630707e-02 1.178
R-HSA-5654706 FRS-mediated FGFR3 signaling 7.739072e-02 1.111
R-HSA-5654712 FRS-mediated FGFR4 signaling 8.014144e-02 1.096
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 4.659614e-02 1.332
R-HSA-877312 Regulation of IFNG signaling 4.659614e-02 1.332
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 5.226903e-02 1.282
R-HSA-389513 Co-inhibition by CTLA4 7.186509e-02 1.143
R-HSA-912694 Regulation of IFNA/IFNB signaling 8.014144e-02 1.096
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 4.632911e-02 1.334
R-HSA-6807070 PTEN Regulation 7.901697e-02 1.102
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 5.226903e-02 1.282
R-HSA-112409 RAF-independent MAPK1/3 activation 8.014144e-02 1.096
R-HSA-1059683 Interleukin-6 signaling 4.943673e-02 1.306
R-HSA-210990 PECAM1 interactions 4.089000e-02 1.388
R-HSA-1170546 Prolactin receptor signaling 5.226903e-02 1.282
R-HSA-1257604 PIP3 activates AKT signaling 6.760237e-02 1.170
R-HSA-432142 Platelet sensitization by LDL 6.630707e-02 1.178
R-HSA-391160 Signal regulatory protein family interactions 5.226903e-02 1.282
R-HSA-1295596 Spry regulation of FGF signaling 5.509307e-02 1.259
R-HSA-210993 Tie2 Signaling 6.630707e-02 1.178
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 6.071646e-02 1.217
R-HSA-2028269 Signaling by Hippo 6.351585e-02 1.197
R-HSA-168256 Immune System 6.144522e-02 1.212
R-HSA-8943723 Regulation of PTEN mRNA translation 8.288413e-02 1.082
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 8.288413e-02 1.082
R-HSA-8854691 Interleukin-20 family signaling 8.288413e-02 1.082
R-HSA-8856828 Clathrin-mediated endocytosis 8.339120e-02 1.079
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 8.561881e-02 1.067
R-HSA-6783589 Interleukin-6 family signaling 8.561881e-02 1.067
R-HSA-5654695 PI-3K cascade:FGFR2 8.834550e-02 1.054
R-HSA-5654693 FRS-mediated FGFR1 signaling 8.834550e-02 1.054
R-HSA-9932444 ATP-dependent chromatin remodelers 8.834550e-02 1.054
R-HSA-9932451 SWI/SNF chromatin remodelers 8.834550e-02 1.054
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 9.106424e-02 1.041
R-HSA-446652 Interleukin-1 family signaling 9.144764e-02 1.039
R-HSA-9006925 Intracellular signaling by second messengers 9.330830e-02 1.030
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 9.377503e-02 1.028
R-HSA-9006115 Signaling by NTRK2 (TRKB) 9.377503e-02 1.028
R-HSA-5654700 FRS-mediated FGFR2 signaling 9.647791e-02 1.016
R-HSA-5654732 Negative regulation of FGFR3 signaling 9.647791e-02 1.016
R-HSA-392499 Metabolism of proteins 9.879142e-02 1.005
R-HSA-5654708 Downstream signaling of activated FGFR3 9.917289e-02 1.004
R-HSA-5654733 Negative regulation of FGFR4 signaling 9.917289e-02 1.004
R-HSA-9674555 Signaling by CSF3 (G-CSF) 9.917289e-02 1.004
R-HSA-5654716 Downstream signaling of activated FGFR4 1.018600e-01 0.992
R-HSA-399719 Trafficking of AMPA receptors 1.045393e-01 0.981
R-HSA-186763 Downstream signal transduction 1.045393e-01 0.981
R-HSA-5654726 Negative regulation of FGFR1 signaling 1.098743e-01 0.959
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 1.098743e-01 0.959
R-HSA-5223345 Miscellaneous transport and binding events 1.125302e-01 0.949
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 1.151783e-01 0.939
R-HSA-5654727 Negative regulation of FGFR2 signaling 1.151783e-01 0.939
R-HSA-5654696 Downstream signaling of activated FGFR2 1.178186e-01 0.929
R-HSA-5654687 Downstream signaling of activated FGFR1 1.178186e-01 0.929
R-HSA-9682385 FLT3 signaling in disease 1.204513e-01 0.919
R-HSA-114604 GPVI-mediated activation cascade 1.204513e-01 0.919
R-HSA-8853659 RET signaling 1.204513e-01 0.919
R-HSA-1296072 Voltage gated Potassium channels 1.230762e-01 0.910
R-HSA-4641258 Degradation of DVL 1.230762e-01 0.910
R-HSA-8953750 Transcriptional Regulation by E2F6 1.283031e-01 0.892
R-HSA-9607240 FLT3 Signaling 1.334995e-01 0.875
R-HSA-6811438 Intra-Golgi traffic 1.360863e-01 0.866
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 1.386656e-01 0.858
R-HSA-5654743 Signaling by FGFR4 1.412373e-01 0.850
R-HSA-1433557 Signaling by SCF-KIT 1.412373e-01 0.850
R-HSA-3214858 RMTs methylate histone arginines 1.438015e-01 0.842
R-HSA-373752 Netrin-1 signaling 1.438015e-01 0.842
R-HSA-4608870 Asymmetric localization of PCP proteins 1.463581e-01 0.835
R-HSA-5654741 Signaling by FGFR3 1.463581e-01 0.835
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.463581e-01 0.835
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 1.514491e-01 0.820
R-HSA-109704 PI3K Cascade 1.590299e-01 0.799
R-HSA-445355 Smooth Muscle Contraction 1.665443e-01 0.778
R-HSA-5654736 Signaling by FGFR1 1.739930e-01 0.759
R-HSA-193648 NRAGE signals death through JNK 1.739930e-01 0.759
R-HSA-177929 Signaling by EGFR 1.739930e-01 0.759
R-HSA-112399 IRS-mediated signalling 1.764614e-01 0.753
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.838232e-01 0.736
R-HSA-8943724 Regulation of PTEN gene transcription 1.838232e-01 0.736
R-HSA-1660661 Sphingolipid de novo biosynthesis 1.838232e-01 0.736
R-HSA-2428928 IRS-related events triggered by IGF1R 1.862628e-01 0.730
R-HSA-186797 Signaling by PDGF 1.886953e-01 0.724
R-HSA-2428924 IGF1R signaling cascade 1.935389e-01 0.713
R-HSA-74751 Insulin receptor signalling cascade 1.935389e-01 0.713
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.959501e-01 0.708
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1.959501e-01 0.708
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.031413e-01 0.692
R-HSA-416476 G alpha (q) signalling events 2.075202e-01 0.683
R-HSA-204005 COPII-mediated vesicle transport 2.079004e-01 0.682
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.149870e-01 0.668
R-HSA-76002 Platelet activation, signaling and aggregation 2.184499e-01 0.661
R-HSA-1643685 Disease 2.203025e-01 0.657
R-HSA-4086400 PCP/CE pathway 2.266602e-01 0.645
R-HSA-9659379 Sensory processing of sound 2.289744e-01 0.640
R-HSA-5654738 Signaling by FGFR2 2.312817e-01 0.636
R-HSA-6806834 Signaling by MET 2.312817e-01 0.636
R-HSA-6802957 Oncogenic MAPK signaling 2.427176e-01 0.615
R-HSA-74752 Signaling by Insulin receptor 2.628838e-01 0.580
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2.672933e-01 0.573
R-HSA-1296071 Potassium Channels 2.738591e-01 0.562
R-HSA-190236 Signaling by FGFR 2.782042e-01 0.556
R-HSA-193704 p75 NTR receptor-mediated signalling 2.803672e-01 0.552
R-HSA-9842860 Regulation of endogenous retroelements 2.868183e-01 0.542
R-HSA-2559580 Oxidative Stress Induced Senescence 2.868183e-01 0.542
R-HSA-418346 Platelet homeostasis 2.974444e-01 0.527
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3.058336e-01 0.515
R-HSA-166166 MyD88-independent TLR4 cascade 3.058336e-01 0.515
R-HSA-1483249 Inositol phosphate metabolism 3.099913e-01 0.509
R-HSA-909733 Interferon alpha/beta signaling 3.202792e-01 0.494
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.263796e-01 0.486
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.364282e-01 0.473
R-HSA-194138 Signaling by VEGF 3.423867e-01 0.465
R-HSA-114608 Platelet degranulation 3.463299e-01 0.461
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 3.518167e-01 0.454
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.522013e-01 0.453
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 3.599496e-01 0.444
R-HSA-3858494 Beta-catenin independent WNT signaling 3.676072e-01 0.435
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.807926e-01 0.419
R-HSA-166520 Signaling by NTRKs 3.918798e-01 0.407
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.918798e-01 0.407
R-HSA-9856651 MITF-M-dependent gene expression 3.955322e-01 0.403
R-HSA-9609507 Protein localization 4.009705e-01 0.397
R-HSA-73887 Death Receptor Signaling 4.027726e-01 0.395
R-HSA-877300 Interferon gamma signaling 4.117037e-01 0.385
R-HSA-6798695 Neutrophil degranulation 4.188964e-01 0.378
R-HSA-2559583 Cellular Senescence 4.494718e-01 0.347
R-HSA-201681 TCF dependent signaling in response to WNT 4.544344e-01 0.343
R-HSA-168898 Toll-like Receptor Cascades 4.674550e-01 0.330
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.776003e-01 0.321
R-HSA-389948 Co-inhibition by PD-1 4.817395e-01 0.317
R-HSA-428157 Sphingolipid metabolism 4.833033e-01 0.316
R-HSA-397014 Muscle contraction 5.017126e-01 0.300
R-HSA-9730414 MITF-M-regulated melanocyte development 5.032173e-01 0.298
R-HSA-9705683 SARS-CoV-2-host interactions 5.252623e-01 0.280
R-HSA-3247509 Chromatin modifying enzymes 5.338094e-01 0.273
R-HSA-202733 Cell surface interactions at the vascular wall 5.380263e-01 0.269
R-HSA-500792 GPCR ligand binding 5.472488e-01 0.262
R-HSA-4839726 Chromatin organization 5.545236e-01 0.256
R-HSA-388841 Regulation of T cell activation by CD28 family 5.638791e-01 0.249
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 5.684597e-01 0.245
R-HSA-449147 Signaling by Interleukins 5.788036e-01 0.237
R-HSA-9658195 Leishmania infection 5.957475e-01 0.225
R-HSA-9824443 Parasitic Infection Pathways 5.957475e-01 0.225
R-HSA-5684996 MAPK1/MAPK3 signaling 6.137618e-01 0.212
R-HSA-195721 Signaling by WNT 6.161036e-01 0.210
R-HSA-1500931 Cell-Cell communication 6.365630e-01 0.196
R-HSA-212165 Epigenetic regulation of gene expression 6.442277e-01 0.191
R-HSA-5683057 MAPK family signaling cascades 6.693241e-01 0.174
R-HSA-9694516 SARS-CoV-2 Infection 6.713354e-01 0.173
R-HSA-388396 GPCR downstream signalling 6.925778e-01 0.160
R-HSA-372790 Signaling by GPCR 7.445274e-01 0.128
R-HSA-168249 Innate Immune System 7.781319e-01 0.109
R-HSA-9679506 SARS-CoV Infections 8.259490e-01 0.083
R-HSA-212436 Generic Transcription Pathway 8.602360e-01 0.065
R-HSA-73857 RNA Polymerase II Transcription 8.978038e-01 0.047
R-HSA-74160 Gene expression (Transcription) 9.462789e-01 0.024
R-HSA-382551 Transport of small molecules 9.542124e-01 0.020
R-HSA-9709957 Sensory Perception 9.798477e-01 0.009
R-HSA-556833 Metabolism of lipids 9.911112e-01 0.004
R-HSA-1430728 Metabolism 9.999559e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.682 0.214 1 0.734
PIM3PIM3 0.678 0.136 -3 0.442
MOSMOS 0.676 0.165 1 0.796
MARK3MARK3 0.673 0.194 4 0.623
MARK4MARK4 0.673 0.166 4 0.640
NDR2NDR2 0.672 0.151 -3 0.496
QSKQSK 0.671 0.190 4 0.623
AMPKA2AMPKA2 0.670 0.203 -3 0.489
AMPKA1AMPKA1 0.669 0.203 -3 0.482
COTCOT 0.669 0.107 2 0.518
CDC7CDC7 0.668 0.072 1 0.802
PRPKPRPK 0.667 0.129 -1 0.759
BRSK1BRSK1 0.667 0.170 -3 0.455
PIM1PIM1 0.667 0.109 -3 0.419
NUAK2NUAK2 0.667 0.170 -3 0.474
GRK1GRK1 0.666 0.134 -2 0.750
SKMLCKSKMLCK 0.666 0.131 -2 0.669
SIKSIK 0.664 0.157 -3 0.437
MARK2MARK2 0.664 0.139 4 0.604
MARK1MARK1 0.662 0.166 4 0.616
RAF1RAF1 0.662 0.082 1 0.634
CLK2CLK2 0.661 0.161 -3 0.417
DAPK2DAPK2 0.660 0.102 -3 0.406
CAMK1BCAMK1B 0.660 0.092 -3 0.417
TSSK1TSSK1 0.659 0.167 -3 0.499
GRK7GRK7 0.659 0.122 1 0.647
PRKXPRKX 0.659 0.147 -3 0.483
NDR1NDR1 0.659 0.124 -3 0.466
RSK4RSK4 0.658 0.100 -3 0.416
BMPR1BBMPR1B 0.658 0.089 1 0.757
P70S6KBP70S6KB 0.657 0.100 -3 0.410
MELKMELK 0.656 0.156 -3 0.463
IKKAIKKA 0.656 0.037 -2 0.678
CHK1CHK1 0.656 0.118 -3 0.503
QIKQIK 0.656 0.151 -3 0.424
CAMK2GCAMK2G 0.655 -0.002 2 0.503
CDKL1CDKL1 0.655 0.008 -3 0.338
TSSK2TSSK2 0.655 0.112 -5 0.601
LATS1LATS1 0.655 0.105 -3 0.481
ERK5ERK5 0.655 0.009 1 0.654
PKACBPKACB 0.654 0.105 -2 0.470
LATS2LATS2 0.654 0.097 -5 0.555
PIM2PIM2 0.654 0.097 -3 0.385
PASKPASK 0.654 0.119 -3 0.436
BRSK2BRSK2 0.654 0.163 -3 0.460
NIKNIK 0.654 0.113 -3 0.439
PRKD2PRKD2 0.653 0.120 -3 0.485
DAPK3DAPK3 0.653 0.139 -3 0.453
CAMLCKCAMLCK 0.653 0.042 -2 0.659
RSK2RSK2 0.653 0.076 -3 0.401
DCAMKL1DCAMKL1 0.652 0.161 -3 0.520
CAMK2BCAMK2B 0.652 0.085 2 0.480
NUAK1NUAK1 0.652 0.110 -3 0.468
CAMK2ACAMK2A 0.652 0.100 2 0.504
NLKNLK 0.652 0.021 1 0.656
BMPR2BMPR2 0.652 -0.081 -2 0.685
HUNKHUNK 0.652 0.019 2 0.508
DYRK2DYRK2 0.651 0.066 1 0.535
GSK3AGSK3A 0.650 0.100 4 0.516
GRK6GRK6 0.649 0.011 1 0.695
ATMATM 0.649 0.020 1 0.623
ATRATR 0.649 -0.036 1 0.664
IKKBIKKB 0.649 -0.012 -2 0.694
DAPK1DAPK1 0.648 0.114 -3 0.411
MTORMTOR 0.648 -0.013 1 0.589
DYRK4DYRK4 0.648 0.083 1 0.498
CAMK4CAMK4 0.648 0.124 -3 0.469
DRAK1DRAK1 0.648 0.086 1 0.666
PAK1PAK1 0.647 0.073 -2 0.612
GRK5GRK5 0.647 -0.060 -3 0.345
JNK3JNK3 0.647 0.042 1 0.548
MSK1MSK1 0.647 0.040 -3 0.349
P90RSKP90RSK 0.647 0.031 -3 0.367
AURCAURC 0.646 0.089 -2 0.451
SSTKSSTK 0.646 0.154 4 0.596
HIPK4HIPK4 0.646 0.022 1 0.635
NIM1NIM1 0.646 0.024 3 0.689
WNK1WNK1 0.646 0.108 -2 0.712
PRKD1PRKD1 0.646 0.018 -3 0.429
PKACGPKACG 0.646 0.076 -2 0.559
MYLK4MYLK4 0.646 0.074 -2 0.593
PKN3PKN3 0.646 0.010 -3 0.407
PKN2PKN2 0.645 0.078 -3 0.446
ICKICK 0.645 0.003 -3 0.377
PDHK4PDHK4 0.645 -0.173 1 0.649
CAMK1DCAMK1D 0.645 0.098 -3 0.428
GRK2GRK2 0.645 0.028 -2 0.626
JNK2JNK2 0.644 0.045 1 0.511
GSK3BGSK3B 0.644 0.092 4 0.512
MASTLMASTL 0.644 -0.104 -2 0.699
MST4MST4 0.644 0.063 2 0.444
WNK3WNK3 0.644 0.047 1 0.592
SRPK1SRPK1 0.643 0.026 -3 0.340
RIPK3RIPK3 0.643 0.024 3 0.643
TGFBR1TGFBR1 0.643 -0.016 -2 0.587
CHAK2CHAK2 0.642 -0.027 -1 0.652
MNK1MNK1 0.642 0.152 -2 0.594
MAPKAPK2MAPKAPK2 0.642 0.039 -3 0.427
SGK3SGK3 0.642 0.073 -3 0.419
ACVR2BACVR2B 0.642 0.005 -2 0.578
BMPR1ABMPR1A 0.642 0.046 1 0.747
DSTYKDSTYK 0.642 -0.066 2 0.512
TBK1TBK1 0.642 -0.063 1 0.486
CDKL5CDKL5 0.642 -0.005 -3 0.328
BRAFBRAF 0.642 0.012 -4 0.551
CK2A2CK2A2 0.642 0.074 1 0.748
AKT2AKT2 0.642 0.054 -3 0.370
DYRK1BDYRK1B 0.642 0.069 1 0.519
DLKDLK 0.641 -0.053 1 0.626
ALK2ALK2 0.641 0.015 -2 0.612
MSK2MSK2 0.641 -0.005 -3 0.326
HIPK1HIPK1 0.641 0.071 1 0.549
AURBAURB 0.641 0.075 -2 0.459
GAKGAK 0.640 0.110 1 0.699
NEK6NEK6 0.640 -0.046 -2 0.647
GRK4GRK4 0.639 -0.035 -2 0.716
ALK4ALK4 0.639 -0.036 -2 0.623
SBKSBK 0.639 0.052 -3 0.331
PLK3PLK3 0.639 -0.006 2 0.514
MAPKAPK3MAPKAPK3 0.639 0.032 -3 0.433
CDK8CDK8 0.638 0.005 1 0.549
MLK2MLK2 0.638 -0.089 2 0.458
MRCKAMRCKA 0.638 0.134 -3 0.431
FAM20CFAM20C 0.638 -0.015 2 0.323
CAMK2DCAMK2D 0.638 -0.015 -3 0.408
RIPK1RIPK1 0.638 -0.029 1 0.579
MLK1MLK1 0.638 -0.078 2 0.438
AKT1AKT1 0.638 0.082 -3 0.411
TAO3TAO3 0.638 0.104 1 0.573
CLK4CLK4 0.637 0.072 -3 0.395
AURAAURA 0.637 0.033 -2 0.432
PAK3PAK3 0.637 0.041 -2 0.616
IKKEIKKE 0.637 -0.086 1 0.474
PKCDPKCD 0.637 0.023 2 0.417
CDK5CDK5 0.637 0.028 1 0.601
CAMK1GCAMK1G 0.637 0.052 -3 0.381
RSK3RSK3 0.637 0.004 -3 0.392
VRK2VRK2 0.637 -0.097 1 0.652
CK2A1CK2A1 0.636 0.077 1 0.724
MEK1MEK1 0.636 -0.099 2 0.512
DMPK1DMPK1 0.636 0.157 -3 0.478
PKACAPKACA 0.636 0.067 -2 0.410
PAK2PAK2 0.636 0.032 -2 0.612
CDK7CDK7 0.636 0.018 1 0.579
CDK18CDK18 0.636 0.028 1 0.519
MPSK1MPSK1 0.635 0.051 1 0.657
CDK16CDK16 0.635 0.048 1 0.499
CLK1CLK1 0.635 0.097 -3 0.432
PLK1PLK1 0.635 -0.025 -2 0.603
PRKD3PRKD3 0.635 0.036 -3 0.424
GRK3GRK3 0.635 0.030 -2 0.602
PRP4PRP4 0.635 -0.039 -3 0.273
CDK1CDK1 0.635 0.024 1 0.552
HIPK2HIPK2 0.635 0.048 1 0.481
PDHK1PDHK1 0.634 -0.210 1 0.599
SNRKSNRK 0.634 0.033 2 0.462
DNAPKDNAPK 0.634 -0.016 1 0.500
DYRK1ADYRK1A 0.634 0.016 1 0.592
CDK17CDK17 0.633 0.025 1 0.478
DCAMKL2DCAMKL2 0.633 0.089 -3 0.516
P38AP38A 0.633 0.006 1 0.576
PKRPKR 0.633 -0.046 1 0.628
NEK7NEK7 0.633 -0.124 -3 0.325
MAKMAK 0.633 0.061 -2 0.571
MLK3MLK3 0.633 -0.049 2 0.381
JNK1JNK1 0.633 0.030 1 0.526
GCN2GCN2 0.633 -0.120 2 0.471
LKB1LKB1 0.633 -0.015 -3 0.355
SMMLCKSMMLCK 0.633 0.032 -3 0.386
ROCK2ROCK2 0.633 0.124 -3 0.452
ANKRD3ANKRD3 0.632 -0.121 1 0.624
ULK2ULK2 0.632 -0.151 2 0.449
CDK14CDK14 0.632 0.046 1 0.536
P38BP38B 0.632 0.007 1 0.521
P38GP38G 0.632 0.016 1 0.462
SRPK2SRPK2 0.632 0.008 -3 0.294
MLK4MLK4 0.632 -0.044 2 0.396
CDK19CDK19 0.631 0.007 1 0.513
PLK2PLK2 0.631 0.014 -3 0.347
DYRK3DYRK3 0.631 0.053 1 0.528
SGK1SGK1 0.631 0.036 -3 0.314
SRPK3SRPK3 0.631 0.001 -3 0.299
P70S6KP70S6K 0.631 0.021 -3 0.329
ACVR2AACVR2A 0.631 -0.044 -2 0.551
PKCGPKCG 0.630 0.032 2 0.380
MOKMOK 0.630 0.105 1 0.560
MST3MST3 0.630 0.040 2 0.472
PAK6PAK6 0.630 0.110 -2 0.561
TLK2TLK2 0.630 -0.074 1 0.619
MNK2MNK2 0.630 0.074 -2 0.584
PINK1PINK1 0.630 -0.059 1 0.709
ERK2ERK2 0.630 -0.000 1 0.546
MRCKBMRCKB 0.630 0.099 -3 0.422
PKCBPKCB 0.630 0.015 2 0.377
ERK1ERK1 0.629 0.005 1 0.511
PKG2PKG2 0.629 0.051 -2 0.479
WNK4WNK4 0.629 0.040 -2 0.716
YSK4YSK4 0.628 -0.105 1 0.540
CK1ECK1E 0.628 -0.023 -3 0.171
PKCAPKCA 0.628 0.000 2 0.356
IRE1IRE1 0.627 -0.027 1 0.581
MEK5MEK5 0.627 -0.093 2 0.486
NEK9NEK9 0.627 -0.168 2 0.447
MEKK3MEKK3 0.626 -0.045 1 0.560
GCKGCK 0.626 0.040 1 0.587
CDK10CDK10 0.626 0.062 1 0.534
PKCZPKCZ 0.626 -0.009 2 0.410
TGFBR2TGFBR2 0.626 -0.096 -2 0.552
CAMK1ACAMK1A 0.626 0.047 -3 0.414
P38DP38D 0.626 0.011 1 0.478
IRE2IRE2 0.625 -0.026 2 0.423
PBKPBK 0.625 0.043 1 0.619
PKCHPKCH 0.625 0.004 2 0.362
CK1DCK1D 0.625 -0.035 -3 0.140
NEK5NEK5 0.624 -0.090 1 0.615
SMG1SMG1 0.624 -0.081 1 0.609
TTBK2TTBK2 0.624 -0.105 2 0.403
AKT3AKT3 0.624 0.034 -3 0.338
HIPK3HIPK3 0.623 0.014 1 0.521
KISKIS 0.623 0.009 1 0.558
CAMKK1CAMKK1 0.623 -0.087 -2 0.677
CDK13CDK13 0.623 -0.026 1 0.546
BCKDKBCKDK 0.623 -0.144 -1 0.633
CRIKCRIK 0.623 0.060 -3 0.391
ULK1ULK1 0.622 -0.161 -3 0.292
TAO2TAO2 0.622 0.033 2 0.458
CHK2CHK2 0.622 0.038 -3 0.371
MEKK2MEKK2 0.622 -0.096 2 0.451
CAMKK2CAMKK2 0.621 -0.074 -2 0.654
ROCK1ROCK1 0.621 0.109 -3 0.427
MEKK1MEKK1 0.621 -0.149 1 0.557
PLK4PLK4 0.620 -0.063 2 0.428
TAK1TAK1 0.620 -0.024 1 0.678
CHAK1CHAK1 0.620 -0.095 2 0.433
PHKG1PHKG1 0.619 0.012 -3 0.467
ZAKZAK 0.619 -0.115 1 0.526
ALPHAK3ALPHAK3 0.619 0.135 -1 0.762
PDK1PDK1 0.619 -0.055 1 0.594
TLK1TLK1 0.619 -0.087 -2 0.624
LRRK2LRRK2 0.618 -0.017 2 0.479
CDK9CDK9 0.618 -0.020 1 0.539
NEK8NEK8 0.618 -0.093 2 0.461
CDK12CDK12 0.617 -0.023 1 0.514
IRAK4IRAK4 0.617 -0.034 1 0.559
VRK1VRK1 0.617 -0.023 2 0.508
NEK11NEK11 0.617 -0.088 1 0.566
PHKG2PHKG2 0.616 0.102 -3 0.502
CDK2CDK2 0.616 -0.045 1 0.598
HPK1HPK1 0.616 0.011 1 0.548
HRIHRI 0.615 -0.117 -2 0.627
CDK3CDK3 0.615 0.001 1 0.502
NEK2NEK2 0.614 -0.166 2 0.437
PERKPERK 0.614 -0.139 -2 0.639
TNIKTNIK 0.613 -0.020 3 0.638
CK1A2CK1A2 0.613 -0.062 -3 0.142
ERK7ERK7 0.612 -0.044 2 0.243
MAP3K15MAP3K15 0.612 -0.075 1 0.514
PKCTPKCT 0.612 -0.021 2 0.370
MST2MST2 0.611 -0.126 1 0.574
PAK5PAK5 0.611 0.047 -2 0.491
CDK4CDK4 0.611 0.015 1 0.506
SLKSLK 0.610 -0.003 -2 0.578
PKCEPKCE 0.610 0.018 2 0.359
KHS1KHS1 0.610 -0.006 1 0.520
KHS2KHS2 0.609 0.019 1 0.550
MEKK6MEKK6 0.609 -0.090 1 0.557
CDK6CDK6 0.609 0.002 1 0.518
IRAK1IRAK1 0.607 -0.142 -1 0.561
MST1MST1 0.607 -0.089 1 0.538
BUB1BUB1 0.607 0.006 -5 0.523
NEK1NEK1 0.607 -0.106 1 0.556
PKN1PKN1 0.607 -0.001 -3 0.369
LOKLOK 0.606 -0.018 -2 0.609
HGKHGK 0.606 -0.088 3 0.647
PAK4PAK4 0.605 0.034 -2 0.478
MINKMINK 0.605 -0.111 1 0.542
EEF2KEEF2K 0.604 -0.088 3 0.605
NEK4NEK4 0.604 -0.146 1 0.530
PKCIPKCI 0.603 -0.037 2 0.377
OSR1OSR1 0.602 -0.058 2 0.435
YSK1YSK1 0.601 -0.071 2 0.422
MAPKAPK5MAPKAPK5 0.601 -0.126 -3 0.268
MEK2MEK2 0.601 -0.192 2 0.483
HASPINHASPIN 0.600 0.024 -1 0.584
YANK3YANK3 0.599 -0.054 2 0.261
ASK1ASK1 0.598 -0.086 1 0.509
RIPK2RIPK2 0.596 -0.132 1 0.489
STK33STK33 0.596 -0.103 2 0.357
TTKTTK 0.595 -0.073 -2 0.592
BIKEBIKE 0.595 -0.012 1 0.591
TTBK1TTBK1 0.595 -0.136 2 0.363
TAO1TAO1 0.594 -0.002 1 0.464
CK1ACK1A 0.593 -0.048 -3 0.104
CK1G1CK1G1 0.593 -0.105 -3 0.172
MYO3BMYO3B 0.592 -0.075 2 0.449
MYO3AMYO3A 0.591 -0.071 1 0.513
PKG1PKG1 0.589 -0.013 -2 0.393
STLK3STLK3 0.581 -0.145 1 0.489
AAK1AAK1 0.580 -0.001 1 0.511
PDHK3_TYRPDHK3_TYR 0.577 0.197 4 0.623
NEK3NEK3 0.577 -0.218 1 0.490
YANK2YANK2 0.576 -0.064 2 0.241
PDHK4_TYRPDHK4_TYR 0.576 0.185 2 0.578
CK1G3CK1G3 0.570 -0.083 -3 0.090
MAP2K6_TYRMAP2K6_TYR 0.569 0.102 -1 0.736
CK1G2CK1G2 0.569 -0.037 -3 0.140
TESK1_TYRTESK1_TYR 0.566 0.081 3 0.715
MAP2K4_TYRMAP2K4_TYR 0.565 0.050 -1 0.741
BMPR2_TYRBMPR2_TYR 0.564 0.050 -1 0.734
PDHK1_TYRPDHK1_TYR 0.563 0.035 -1 0.724
MAP2K7_TYRMAP2K7_TYR 0.562 0.016 2 0.538
PKMYT1_TYRPKMYT1_TYR 0.562 0.016 3 0.690
LIMK2_TYRLIMK2_TYR 0.561 0.090 -3 0.437
TXKTXK 0.560 0.073 1 0.734
FERFER 0.559 0.038 1 0.741
EPHB4EPHB4 0.557 0.021 -1 0.711
PINK1_TYRPINK1_TYR 0.557 0.018 1 0.671
INSRRINSRR 0.557 0.033 3 0.651
EPHA6EPHA6 0.556 0.027 -1 0.710
LIMK1_TYRLIMK1_TYR 0.556 0.006 2 0.492
BMXBMX 0.555 0.116 -1 0.691
EPHA4EPHA4 0.554 0.011 2 0.523
DDR1DDR1 0.553 0.024 4 0.561
JAK3JAK3 0.551 -0.000 1 0.565
ABL2ABL2 0.550 0.029 -1 0.702
SRMSSRMS 0.550 -0.006 1 0.707
ROS1ROS1 0.549 -0.030 3 0.664
TYRO3TYRO3 0.549 -0.036 3 0.669
EPHB1EPHB1 0.549 -0.020 1 0.667
EPHB2EPHB2 0.548 -0.013 -1 0.684
RETRET 0.548 -0.032 1 0.553
MATKMATK 0.548 0.078 -1 0.729
FGFR2FGFR2 0.548 0.007 3 0.672
EPHB3EPHB3 0.548 -0.029 -1 0.686
MERTKMERTK 0.547 0.002 3 0.674
MST1RMST1R 0.547 -0.040 3 0.673
KDRKDR 0.546 0.038 3 0.641
EPHA5EPHA5 0.546 0.021 2 0.524
ITKITK 0.546 0.007 -1 0.611
KITKIT 0.546 0.007 3 0.670
TEKTEK 0.546 -0.001 3 0.631
LTKLTK 0.546 0.047 3 0.633
ABL1ABL1 0.545 -0.015 -1 0.677
YES1YES1 0.545 -0.037 -1 0.614
FGRFGR 0.545 -0.057 1 0.683
CSF1RCSF1R 0.545 -0.059 3 0.668
FGFR3FGFR3 0.544 0.011 3 0.653
METMET 0.544 0.010 3 0.666
WEE1_TYRWEE1_TYR 0.544 0.070 -1 0.733
ALKALK 0.544 0.027 3 0.622
TNK2TNK2 0.543 -0.017 3 0.640
FGFR1FGFR1 0.542 -0.044 3 0.665
TYK2TYK2 0.542 -0.119 1 0.547
SYKSYK 0.541 0.050 -1 0.697
PTK6PTK6 0.541 -0.024 -1 0.648
INSRINSR 0.541 -0.018 3 0.622
PTK2BPTK2B 0.540 -0.006 -1 0.590
DDR2DDR2 0.540 0.051 3 0.625
EPHA3EPHA3 0.540 -0.041 2 0.509
LCKLCK 0.539 -0.042 -1 0.615
EPHA7EPHA7 0.539 -0.031 2 0.502
BLKBLK 0.538 -0.015 -1 0.601
AXLAXL 0.538 -0.048 3 0.684
NTRK1NTRK1 0.538 -0.058 -1 0.751
FLT3FLT3 0.538 -0.039 3 0.646
JAK2JAK2 0.538 -0.146 1 0.539
NTRK3NTRK3 0.537 -0.011 -1 0.780
FYNFYN 0.537 -0.020 -1 0.596
NEK10_TYRNEK10_TYR 0.537 -0.050 1 0.495
FLT1FLT1 0.536 -0.021 -1 0.718
HCKHCK 0.536 -0.093 -1 0.610
TECTEC 0.536 -0.019 -1 0.576
PTK2PTK2 0.536 0.005 -1 0.609
EPHA8EPHA8 0.536 -0.030 -1 0.684
PDGFRBPDGFRB 0.536 -0.080 3 0.683
FLT4FLT4 0.534 -0.022 3 0.636
TNK1TNK1 0.533 -0.029 3 0.658
ERBB2ERBB2 0.533 -0.059 1 0.548
EPHA2EPHA2 0.533 -0.006 -1 0.711
IGF1RIGF1R 0.531 -0.005 3 0.580
NTRK2NTRK2 0.531 -0.083 3 0.652
EGFREGFR 0.531 -0.025 1 0.472
CSKCSK 0.531 -0.036 2 0.514
BTKBTK 0.530 -0.094 -1 0.582
FESFES 0.530 0.030 -1 0.676
FGFR4FGFR4 0.530 -0.009 -1 0.743
TNNI3K_TYRTNNI3K_TYR 0.529 -0.091 1 0.538
ZAP70ZAP70 0.529 0.059 -1 0.734
FRKFRK 0.528 -0.066 -1 0.627
PDGFRAPDGFRA 0.528 -0.115 3 0.673
JAK1JAK1 0.528 -0.088 1 0.465
EPHA1EPHA1 0.526 -0.080 3 0.650
LYNLYN 0.526 -0.090 3 0.591
SRCSRC 0.524 -0.073 -1 0.593
ERBB4ERBB4 0.522 -0.036 1 0.524
MUSKMUSK 0.517 -0.040 1 0.460