Motif 131 (n=44)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
O14641 | DVL2 | S614 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
O43314 | PPIP5K2 | S788 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
P0DPH7 | TUBA3C | T225 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0DPH8 | TUBA3D | T225 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P16389 | KCNA2 | S440 | ochoa | Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11211111, PubMed:19912772, PubMed:23769686, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20220134, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). {ECO:0000250|UniProtKB:P63141, ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:32833227, ECO:0000269|PubMed:35439054, ECO:0000269|PubMed:37883018, ECO:0000269|PubMed:8495559, ECO:0000305}. |
P30414 | NKTR | S887 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
P35226 | BMI1 | S251 | ochoa | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332). {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:27827373}. |
P35348 | ADRA1A | S401 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
P46459 | NSF | S437 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
P47756 | CAPZB | S226 | psp | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
P51531 | SMARCA2 | S1408 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P52594 | AGFG1 | S293 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
P68363 | TUBA1B | T225 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
P68366 | TUBA4A | T225 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q02487 | DSC2 | S824 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
Q08495 | DMTN | S269 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q14574 | DSC3 | S819 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
Q15746 | MYLK | S947 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
Q17R98 | ZNF827 | S961 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
Q5R372 | RABGAP1L | S71 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
Q6PEY2 | TUBA3E | T225 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q6ZVD7 | STOX1 | S392 | ochoa | Storkhead-box protein 1 (Winged-helix domain-containing protein) | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}. |
Q71U36 | TUBA1A | T225 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q86UE4 | MTDH | S251 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
Q8IVL0 | NAV3 | S1670 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
Q8N0Z3 | SPICE1 | T230 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
Q8N264 | ARHGAP24 | S626 | ochoa | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
Q8NEF9 | SRFBP1 | S140 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
Q8NEY1 | NAV1 | S1182 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8WUY3 | PRUNE2 | T1620 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
Q8WWK9 | CKAP2 | S304 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
Q92622 | RUBCN | S197 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
Q96DF8 | ESS2 | S391 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
Q9BQE3 | TUBA1C | T225 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9NQW6 | ANLN | S274 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NY61 | AATF | S61 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
Q9NY65 | TUBA8 | T225 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9P0L0 | VAPA | S214 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
Q9ULL8 | SHROOM4 | S785 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
Q9UPV9 | TRAK1 | S535 | ochoa | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}. |
R4GMX3 | COMMD3-BMI1 | S394 | ochoa | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000256|ARBA:ARBA00045235}. |
Q06124 | PTPN11 | S134 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}. |
P17948 | FLT1 | S1205 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
Q9BX40 | LSM14B | T343 | Sugiyama | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.329870e-15 | 14.364 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 6.217249e-15 | 14.206 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.210143e-14 | 13.917 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 5.129230e-14 | 13.290 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.382228e-13 | 12.859 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.701173e-13 | 12.568 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.138600e-13 | 12.503 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.097833e-13 | 12.387 |
R-HSA-190861 | Gap junction assembly | 6.087353e-13 | 12.216 |
R-HSA-6807878 | COPI-mediated anterograde transport | 8.719692e-13 | 12.059 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.650791e-12 | 11.782 |
R-HSA-9646399 | Aggrephagy | 1.791345e-12 | 11.747 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.489120e-12 | 11.604 |
R-HSA-190828 | Gap junction trafficking | 3.977596e-12 | 11.400 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.188827e-12 | 11.208 |
R-HSA-437239 | Recycling pathway of L1 | 6.188827e-12 | 11.208 |
R-HSA-157858 | Gap junction trafficking and regulation | 8.199441e-12 | 11.086 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.045919e-11 | 10.689 |
R-HSA-983189 | Kinesins | 3.283152e-11 | 10.484 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.352574e-11 | 10.475 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.121758e-11 | 10.385 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 5.850287e-11 | 10.233 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.063327e-10 | 9.973 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.293028e-10 | 9.888 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.470933e-10 | 9.607 |
R-HSA-9833482 | PKR-mediated signaling | 2.470933e-10 | 9.607 |
R-HSA-2132295 | MHC class II antigen presentation | 2.903302e-10 | 9.537 |
R-HSA-390466 | Chaperonin-mediated protein folding | 4.869435e-10 | 9.313 |
R-HSA-438064 | Post NMDA receptor activation events | 4.869435e-10 | 9.313 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.278628e-10 | 9.277 |
R-HSA-9663891 | Selective autophagy | 5.278628e-10 | 9.277 |
R-HSA-391251 | Protein folding | 7.804422e-10 | 9.108 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.832733e-10 | 9.054 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.631580e-10 | 9.016 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.728174e-09 | 8.762 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.934585e-09 | 8.532 |
R-HSA-373760 | L1CAM interactions | 5.106818e-09 | 8.292 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.866279e-09 | 8.232 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.830643e-09 | 8.166 |
R-HSA-5620924 | Intraflagellar transport | 1.915152e-08 | 7.718 |
R-HSA-1632852 | Macroautophagy | 2.285096e-08 | 7.641 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.699662e-08 | 7.569 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.040991e-08 | 7.517 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.369079e-08 | 7.360 |
R-HSA-9612973 | Autophagy | 4.771220e-08 | 7.321 |
R-HSA-2467813 | Separation of Sister Chromatids | 6.715804e-08 | 7.173 |
R-HSA-69275 | G2/M Transition | 1.653434e-07 | 6.782 |
R-HSA-453274 | Mitotic G2-G2/M phases | 1.779059e-07 | 6.750 |
R-HSA-5617833 | Cilium Assembly | 1.912798e-07 | 6.718 |
R-HSA-68877 | Mitotic Prometaphase | 2.129574e-07 | 6.672 |
R-HSA-9609690 | HCMV Early Events | 2.367119e-07 | 6.626 |
R-HSA-199991 | Membrane Trafficking | 4.535583e-07 | 6.343 |
R-HSA-68882 | Mitotic Anaphase | 4.761558e-07 | 6.322 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.914449e-07 | 6.309 |
R-HSA-446203 | Asparagine N-linked glycosylation | 6.228131e-07 | 6.206 |
R-HSA-112315 | Transmission across Chemical Synapses | 7.136478e-07 | 6.147 |
R-HSA-5610787 | Hedgehog 'off' state | 1.027031e-06 | 5.988 |
R-HSA-9609646 | HCMV Infection | 1.295805e-06 | 5.887 |
R-HSA-112316 | Neuronal System | 1.512853e-06 | 5.820 |
R-HSA-913531 | Interferon Signaling | 2.721548e-06 | 5.565 |
R-HSA-5653656 | Vesicle-mediated transport | 4.226242e-06 | 5.374 |
R-HSA-5358351 | Signaling by Hedgehog | 6.900526e-06 | 5.161 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 7.011284e-06 | 5.154 |
R-HSA-68886 | M Phase | 2.373638e-05 | 4.625 |
R-HSA-422475 | Axon guidance | 3.953456e-05 | 4.403 |
R-HSA-9675108 | Nervous system development | 6.438864e-05 | 4.191 |
R-HSA-162582 | Signal Transduction | 7.098732e-05 | 4.149 |
R-HSA-109582 | Hemostasis | 1.104550e-04 | 3.957 |
R-HSA-69278 | Cell Cycle, Mitotic | 3.187623e-04 | 3.497 |
R-HSA-390696 | Adrenoceptors | 5.154573e-04 | 3.288 |
R-HSA-2262752 | Cellular responses to stress | 8.435810e-04 | 3.074 |
R-HSA-1280218 | Adaptive Immune System | 1.034082e-03 | 2.985 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 1.258836e-03 | 2.900 |
R-HSA-1640170 | Cell Cycle | 1.311922e-03 | 2.882 |
R-HSA-8953897 | Cellular responses to stimuli | 2.013923e-03 | 2.696 |
R-HSA-1266738 | Developmental Biology | 4.099344e-03 | 2.387 |
R-HSA-9008059 | Interleukin-37 signaling | 5.265376e-03 | 2.279 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 6.144555e-03 | 2.212 |
R-HSA-9824446 | Viral Infection Pathways | 6.252849e-03 | 2.204 |
R-HSA-6809371 | Formation of the cornified envelope | 8.167129e-03 | 2.088 |
R-HSA-597592 | Post-translational protein modification | 9.287451e-03 | 2.032 |
R-HSA-375280 | Amine ligand-binding receptors | 1.065887e-02 | 1.972 |
R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 1.185391e-02 | 1.926 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 1.479582e-02 | 1.830 |
R-HSA-8865999 | MET activates PTPN11 | 1.479582e-02 | 1.830 |
R-HSA-9645135 | STAT5 Activation | 2.647794e-02 | 1.577 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.917326e-02 | 1.717 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.917326e-02 | 1.717 |
R-HSA-8854518 | AURKA Activation by TPX2 | 2.071080e-02 | 1.684 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.449076e-02 | 1.611 |
R-HSA-380287 | Centrosome maturation | 2.561893e-02 | 1.591 |
R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 2.357019e-02 | 1.628 |
R-HSA-9927353 | Co-inhibition by BTLA | 2.065394e-02 | 1.685 |
R-HSA-194313 | VEGF ligand-receptor interactions | 2.357019e-02 | 1.628 |
R-HSA-416482 | G alpha (12/13) signalling events | 2.735029e-02 | 1.563 |
R-HSA-5663205 | Infectious disease | 2.748820e-02 | 1.561 |
R-HSA-418886 | Netrin mediated repulsion signals | 2.937722e-02 | 1.532 |
R-HSA-6805567 | Keratinization | 2.992960e-02 | 1.524 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.095034e-02 | 1.509 |
R-HSA-201688 | WNT mediated activation of DVL | 3.515042e-02 | 1.454 |
R-HSA-112411 | MAPK1 (ERK2) activation | 3.515042e-02 | 1.454 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.537368e-02 | 1.451 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.705207e-02 | 1.431 |
R-HSA-110056 | MAPK3 (ERK1) activation | 3.802440e-02 | 1.420 |
R-HSA-2586552 | Signaling by Leptin | 3.802440e-02 | 1.420 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 7.186509e-02 | 1.143 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 5.790887e-02 | 1.237 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 7.186509e-02 | 1.143 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 5.790887e-02 | 1.237 |
R-HSA-9664420 | Killing mechanisms | 5.790887e-02 | 1.237 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 4.943673e-02 | 1.306 |
R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 6.071646e-02 | 1.217 |
R-HSA-180292 | GAB1 signalosome | 6.630707e-02 | 1.178 |
R-HSA-5654710 | PI-3K cascade:FGFR3 | 6.909014e-02 | 1.161 |
R-HSA-5654720 | PI-3K cascade:FGFR4 | 7.186509e-02 | 1.143 |
R-HSA-5654689 | PI-3K cascade:FGFR1 | 8.014144e-02 | 1.096 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 5.509307e-02 | 1.259 |
R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 6.630707e-02 | 1.178 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 7.739072e-02 | 1.111 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 8.014144e-02 | 1.096 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 4.659614e-02 | 1.332 |
R-HSA-877312 | Regulation of IFNG signaling | 4.659614e-02 | 1.332 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 5.226903e-02 | 1.282 |
R-HSA-389513 | Co-inhibition by CTLA4 | 7.186509e-02 | 1.143 |
R-HSA-912694 | Regulation of IFNA/IFNB signaling | 8.014144e-02 | 1.096 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.632911e-02 | 1.334 |
R-HSA-6807070 | PTEN Regulation | 7.901697e-02 | 1.102 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 5.226903e-02 | 1.282 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 8.014144e-02 | 1.096 |
R-HSA-1059683 | Interleukin-6 signaling | 4.943673e-02 | 1.306 |
R-HSA-210990 | PECAM1 interactions | 4.089000e-02 | 1.388 |
R-HSA-1170546 | Prolactin receptor signaling | 5.226903e-02 | 1.282 |
R-HSA-1257604 | PIP3 activates AKT signaling | 6.760237e-02 | 1.170 |
R-HSA-432142 | Platelet sensitization by LDL | 6.630707e-02 | 1.178 |
R-HSA-391160 | Signal regulatory protein family interactions | 5.226903e-02 | 1.282 |
R-HSA-1295596 | Spry regulation of FGF signaling | 5.509307e-02 | 1.259 |
R-HSA-210993 | Tie2 Signaling | 6.630707e-02 | 1.178 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 6.071646e-02 | 1.217 |
R-HSA-2028269 | Signaling by Hippo | 6.351585e-02 | 1.197 |
R-HSA-168256 | Immune System | 6.144522e-02 | 1.212 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 8.288413e-02 | 1.082 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 8.288413e-02 | 1.082 |
R-HSA-8854691 | Interleukin-20 family signaling | 8.288413e-02 | 1.082 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 8.339120e-02 | 1.079 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 8.561881e-02 | 1.067 |
R-HSA-6783589 | Interleukin-6 family signaling | 8.561881e-02 | 1.067 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 8.834550e-02 | 1.054 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 8.834550e-02 | 1.054 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 8.834550e-02 | 1.054 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 8.834550e-02 | 1.054 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 9.106424e-02 | 1.041 |
R-HSA-446652 | Interleukin-1 family signaling | 9.144764e-02 | 1.039 |
R-HSA-9006925 | Intracellular signaling by second messengers | 9.330830e-02 | 1.030 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 9.377503e-02 | 1.028 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 9.377503e-02 | 1.028 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 9.647791e-02 | 1.016 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 9.647791e-02 | 1.016 |
R-HSA-392499 | Metabolism of proteins | 9.879142e-02 | 1.005 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 9.917289e-02 | 1.004 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 9.917289e-02 | 1.004 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 9.917289e-02 | 1.004 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.018600e-01 | 0.992 |
R-HSA-399719 | Trafficking of AMPA receptors | 1.045393e-01 | 0.981 |
R-HSA-186763 | Downstream signal transduction | 1.045393e-01 | 0.981 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.098743e-01 | 0.959 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.098743e-01 | 0.959 |
R-HSA-5223345 | Miscellaneous transport and binding events | 1.125302e-01 | 0.949 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.151783e-01 | 0.939 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.151783e-01 | 0.939 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.178186e-01 | 0.929 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 1.178186e-01 | 0.929 |
R-HSA-9682385 | FLT3 signaling in disease | 1.204513e-01 | 0.919 |
R-HSA-114604 | GPVI-mediated activation cascade | 1.204513e-01 | 0.919 |
R-HSA-8853659 | RET signaling | 1.204513e-01 | 0.919 |
R-HSA-1296072 | Voltage gated Potassium channels | 1.230762e-01 | 0.910 |
R-HSA-4641258 | Degradation of DVL | 1.230762e-01 | 0.910 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.283031e-01 | 0.892 |
R-HSA-9607240 | FLT3 Signaling | 1.334995e-01 | 0.875 |
R-HSA-6811438 | Intra-Golgi traffic | 1.360863e-01 | 0.866 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.386656e-01 | 0.858 |
R-HSA-5654743 | Signaling by FGFR4 | 1.412373e-01 | 0.850 |
R-HSA-1433557 | Signaling by SCF-KIT | 1.412373e-01 | 0.850 |
R-HSA-3214858 | RMTs methylate histone arginines | 1.438015e-01 | 0.842 |
R-HSA-373752 | Netrin-1 signaling | 1.438015e-01 | 0.842 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.463581e-01 | 0.835 |
R-HSA-5654741 | Signaling by FGFR3 | 1.463581e-01 | 0.835 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.463581e-01 | 0.835 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.514491e-01 | 0.820 |
R-HSA-109704 | PI3K Cascade | 1.590299e-01 | 0.799 |
R-HSA-445355 | Smooth Muscle Contraction | 1.665443e-01 | 0.778 |
R-HSA-5654736 | Signaling by FGFR1 | 1.739930e-01 | 0.759 |
R-HSA-193648 | NRAGE signals death through JNK | 1.739930e-01 | 0.759 |
R-HSA-177929 | Signaling by EGFR | 1.739930e-01 | 0.759 |
R-HSA-112399 | IRS-mediated signalling | 1.764614e-01 | 0.753 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.838232e-01 | 0.736 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 1.838232e-01 | 0.736 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.838232e-01 | 0.736 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.862628e-01 | 0.730 |
R-HSA-186797 | Signaling by PDGF | 1.886953e-01 | 0.724 |
R-HSA-2428924 | IGF1R signaling cascade | 1.935389e-01 | 0.713 |
R-HSA-74751 | Insulin receptor signalling cascade | 1.935389e-01 | 0.713 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.959501e-01 | 0.708 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.959501e-01 | 0.708 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.031413e-01 | 0.692 |
R-HSA-416476 | G alpha (q) signalling events | 2.075202e-01 | 0.683 |
R-HSA-204005 | COPII-mediated vesicle transport | 2.079004e-01 | 0.682 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.149870e-01 | 0.668 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 2.184499e-01 | 0.661 |
R-HSA-1643685 | Disease | 2.203025e-01 | 0.657 |
R-HSA-4086400 | PCP/CE pathway | 2.266602e-01 | 0.645 |
R-HSA-9659379 | Sensory processing of sound | 2.289744e-01 | 0.640 |
R-HSA-5654738 | Signaling by FGFR2 | 2.312817e-01 | 0.636 |
R-HSA-6806834 | Signaling by MET | 2.312817e-01 | 0.636 |
R-HSA-6802957 | Oncogenic MAPK signaling | 2.427176e-01 | 0.615 |
R-HSA-74752 | Signaling by Insulin receptor | 2.628838e-01 | 0.580 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.672933e-01 | 0.573 |
R-HSA-1296071 | Potassium Channels | 2.738591e-01 | 0.562 |
R-HSA-190236 | Signaling by FGFR | 2.782042e-01 | 0.556 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.803672e-01 | 0.552 |
R-HSA-9842860 | Regulation of endogenous retroelements | 2.868183e-01 | 0.542 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.868183e-01 | 0.542 |
R-HSA-418346 | Platelet homeostasis | 2.974444e-01 | 0.527 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.058336e-01 | 0.515 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 3.058336e-01 | 0.515 |
R-HSA-1483249 | Inositol phosphate metabolism | 3.099913e-01 | 0.509 |
R-HSA-909733 | Interferon alpha/beta signaling | 3.202792e-01 | 0.494 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.263796e-01 | 0.486 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.364282e-01 | 0.473 |
R-HSA-194138 | Signaling by VEGF | 3.423867e-01 | 0.465 |
R-HSA-114608 | Platelet degranulation | 3.463299e-01 | 0.461 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 3.518167e-01 | 0.454 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.522013e-01 | 0.453 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.599496e-01 | 0.444 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.676072e-01 | 0.435 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.807926e-01 | 0.419 |
R-HSA-166520 | Signaling by NTRKs | 3.918798e-01 | 0.407 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.918798e-01 | 0.407 |
R-HSA-9856651 | MITF-M-dependent gene expression | 3.955322e-01 | 0.403 |
R-HSA-9609507 | Protein localization | 4.009705e-01 | 0.397 |
R-HSA-73887 | Death Receptor Signaling | 4.027726e-01 | 0.395 |
R-HSA-877300 | Interferon gamma signaling | 4.117037e-01 | 0.385 |
R-HSA-6798695 | Neutrophil degranulation | 4.188964e-01 | 0.378 |
R-HSA-2559583 | Cellular Senescence | 4.494718e-01 | 0.347 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 4.544344e-01 | 0.343 |
R-HSA-168898 | Toll-like Receptor Cascades | 4.674550e-01 | 0.330 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.776003e-01 | 0.321 |
R-HSA-389948 | Co-inhibition by PD-1 | 4.817395e-01 | 0.317 |
R-HSA-428157 | Sphingolipid metabolism | 4.833033e-01 | 0.316 |
R-HSA-397014 | Muscle contraction | 5.017126e-01 | 0.300 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.032173e-01 | 0.298 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 5.252623e-01 | 0.280 |
R-HSA-3247509 | Chromatin modifying enzymes | 5.338094e-01 | 0.273 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 5.380263e-01 | 0.269 |
R-HSA-500792 | GPCR ligand binding | 5.472488e-01 | 0.262 |
R-HSA-4839726 | Chromatin organization | 5.545236e-01 | 0.256 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.638791e-01 | 0.249 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.684597e-01 | 0.245 |
R-HSA-449147 | Signaling by Interleukins | 5.788036e-01 | 0.237 |
R-HSA-9658195 | Leishmania infection | 5.957475e-01 | 0.225 |
R-HSA-9824443 | Parasitic Infection Pathways | 5.957475e-01 | 0.225 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.137618e-01 | 0.212 |
R-HSA-195721 | Signaling by WNT | 6.161036e-01 | 0.210 |
R-HSA-1500931 | Cell-Cell communication | 6.365630e-01 | 0.196 |
R-HSA-212165 | Epigenetic regulation of gene expression | 6.442277e-01 | 0.191 |
R-HSA-5683057 | MAPK family signaling cascades | 6.693241e-01 | 0.174 |
R-HSA-9694516 | SARS-CoV-2 Infection | 6.713354e-01 | 0.173 |
R-HSA-388396 | GPCR downstream signalling | 6.925778e-01 | 0.160 |
R-HSA-372790 | Signaling by GPCR | 7.445274e-01 | 0.128 |
R-HSA-168249 | Innate Immune System | 7.781319e-01 | 0.109 |
R-HSA-9679506 | SARS-CoV Infections | 8.259490e-01 | 0.083 |
R-HSA-212436 | Generic Transcription Pathway | 8.602360e-01 | 0.065 |
R-HSA-73857 | RNA Polymerase II Transcription | 8.978038e-01 | 0.047 |
R-HSA-74160 | Gene expression (Transcription) | 9.462789e-01 | 0.024 |
R-HSA-382551 | Transport of small molecules | 9.542124e-01 | 0.020 |
R-HSA-9709957 | Sensory Perception | 9.798477e-01 | 0.009 |
R-HSA-556833 | Metabolism of lipids | 9.911112e-01 | 0.004 |
R-HSA-1430728 | Metabolism | 9.999559e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.682 | 0.214 | 1 | 0.734 |
PIM3 |
0.678 | 0.136 | -3 | 0.442 |
MOS |
0.676 | 0.165 | 1 | 0.796 |
MARK3 |
0.673 | 0.194 | 4 | 0.623 |
MARK4 |
0.673 | 0.166 | 4 | 0.640 |
NDR2 |
0.672 | 0.151 | -3 | 0.496 |
QSK |
0.671 | 0.190 | 4 | 0.623 |
AMPKA2 |
0.670 | 0.203 | -3 | 0.489 |
AMPKA1 |
0.669 | 0.203 | -3 | 0.482 |
COT |
0.669 | 0.107 | 2 | 0.518 |
CDC7 |
0.668 | 0.072 | 1 | 0.802 |
PRPK |
0.667 | 0.129 | -1 | 0.759 |
BRSK1 |
0.667 | 0.170 | -3 | 0.455 |
PIM1 |
0.667 | 0.109 | -3 | 0.419 |
NUAK2 |
0.667 | 0.170 | -3 | 0.474 |
GRK1 |
0.666 | 0.134 | -2 | 0.750 |
SKMLCK |
0.666 | 0.131 | -2 | 0.669 |
SIK |
0.664 | 0.157 | -3 | 0.437 |
MARK2 |
0.664 | 0.139 | 4 | 0.604 |
MARK1 |
0.662 | 0.166 | 4 | 0.616 |
RAF1 |
0.662 | 0.082 | 1 | 0.634 |
CLK2 |
0.661 | 0.161 | -3 | 0.417 |
DAPK2 |
0.660 | 0.102 | -3 | 0.406 |
CAMK1B |
0.660 | 0.092 | -3 | 0.417 |
TSSK1 |
0.659 | 0.167 | -3 | 0.499 |
GRK7 |
0.659 | 0.122 | 1 | 0.647 |
PRKX |
0.659 | 0.147 | -3 | 0.483 |
NDR1 |
0.659 | 0.124 | -3 | 0.466 |
RSK4 |
0.658 | 0.100 | -3 | 0.416 |
BMPR1B |
0.658 | 0.089 | 1 | 0.757 |
P70S6KB |
0.657 | 0.100 | -3 | 0.410 |
MELK |
0.656 | 0.156 | -3 | 0.463 |
IKKA |
0.656 | 0.037 | -2 | 0.678 |
CHK1 |
0.656 | 0.118 | -3 | 0.503 |
QIK |
0.656 | 0.151 | -3 | 0.424 |
CAMK2G |
0.655 | -0.002 | 2 | 0.503 |
CDKL1 |
0.655 | 0.008 | -3 | 0.338 |
TSSK2 |
0.655 | 0.112 | -5 | 0.601 |
LATS1 |
0.655 | 0.105 | -3 | 0.481 |
ERK5 |
0.655 | 0.009 | 1 | 0.654 |
PKACB |
0.654 | 0.105 | -2 | 0.470 |
LATS2 |
0.654 | 0.097 | -5 | 0.555 |
PIM2 |
0.654 | 0.097 | -3 | 0.385 |
PASK |
0.654 | 0.119 | -3 | 0.436 |
BRSK2 |
0.654 | 0.163 | -3 | 0.460 |
NIK |
0.654 | 0.113 | -3 | 0.439 |
PRKD2 |
0.653 | 0.120 | -3 | 0.485 |
DAPK3 |
0.653 | 0.139 | -3 | 0.453 |
CAMLCK |
0.653 | 0.042 | -2 | 0.659 |
RSK2 |
0.653 | 0.076 | -3 | 0.401 |
DCAMKL1 |
0.652 | 0.161 | -3 | 0.520 |
CAMK2B |
0.652 | 0.085 | 2 | 0.480 |
NUAK1 |
0.652 | 0.110 | -3 | 0.468 |
CAMK2A |
0.652 | 0.100 | 2 | 0.504 |
NLK |
0.652 | 0.021 | 1 | 0.656 |
BMPR2 |
0.652 | -0.081 | -2 | 0.685 |
HUNK |
0.652 | 0.019 | 2 | 0.508 |
DYRK2 |
0.651 | 0.066 | 1 | 0.535 |
GSK3A |
0.650 | 0.100 | 4 | 0.516 |
GRK6 |
0.649 | 0.011 | 1 | 0.695 |
ATM |
0.649 | 0.020 | 1 | 0.623 |
ATR |
0.649 | -0.036 | 1 | 0.664 |
IKKB |
0.649 | -0.012 | -2 | 0.694 |
DAPK1 |
0.648 | 0.114 | -3 | 0.411 |
MTOR |
0.648 | -0.013 | 1 | 0.589 |
DYRK4 |
0.648 | 0.083 | 1 | 0.498 |
CAMK4 |
0.648 | 0.124 | -3 | 0.469 |
DRAK1 |
0.648 | 0.086 | 1 | 0.666 |
PAK1 |
0.647 | 0.073 | -2 | 0.612 |
GRK5 |
0.647 | -0.060 | -3 | 0.345 |
JNK3 |
0.647 | 0.042 | 1 | 0.548 |
MSK1 |
0.647 | 0.040 | -3 | 0.349 |
P90RSK |
0.647 | 0.031 | -3 | 0.367 |
AURC |
0.646 | 0.089 | -2 | 0.451 |
SSTK |
0.646 | 0.154 | 4 | 0.596 |
HIPK4 |
0.646 | 0.022 | 1 | 0.635 |
NIM1 |
0.646 | 0.024 | 3 | 0.689 |
WNK1 |
0.646 | 0.108 | -2 | 0.712 |
PRKD1 |
0.646 | 0.018 | -3 | 0.429 |
PKACG |
0.646 | 0.076 | -2 | 0.559 |
MYLK4 |
0.646 | 0.074 | -2 | 0.593 |
PKN3 |
0.646 | 0.010 | -3 | 0.407 |
PKN2 |
0.645 | 0.078 | -3 | 0.446 |
ICK |
0.645 | 0.003 | -3 | 0.377 |
PDHK4 |
0.645 | -0.173 | 1 | 0.649 |
CAMK1D |
0.645 | 0.098 | -3 | 0.428 |
GRK2 |
0.645 | 0.028 | -2 | 0.626 |
JNK2 |
0.644 | 0.045 | 1 | 0.511 |
GSK3B |
0.644 | 0.092 | 4 | 0.512 |
MASTL |
0.644 | -0.104 | -2 | 0.699 |
MST4 |
0.644 | 0.063 | 2 | 0.444 |
WNK3 |
0.644 | 0.047 | 1 | 0.592 |
SRPK1 |
0.643 | 0.026 | -3 | 0.340 |
RIPK3 |
0.643 | 0.024 | 3 | 0.643 |
TGFBR1 |
0.643 | -0.016 | -2 | 0.587 |
CHAK2 |
0.642 | -0.027 | -1 | 0.652 |
MNK1 |
0.642 | 0.152 | -2 | 0.594 |
MAPKAPK2 |
0.642 | 0.039 | -3 | 0.427 |
SGK3 |
0.642 | 0.073 | -3 | 0.419 |
ACVR2B |
0.642 | 0.005 | -2 | 0.578 |
BMPR1A |
0.642 | 0.046 | 1 | 0.747 |
DSTYK |
0.642 | -0.066 | 2 | 0.512 |
TBK1 |
0.642 | -0.063 | 1 | 0.486 |
CDKL5 |
0.642 | -0.005 | -3 | 0.328 |
BRAF |
0.642 | 0.012 | -4 | 0.551 |
CK2A2 |
0.642 | 0.074 | 1 | 0.748 |
AKT2 |
0.642 | 0.054 | -3 | 0.370 |
DYRK1B |
0.642 | 0.069 | 1 | 0.519 |
DLK |
0.641 | -0.053 | 1 | 0.626 |
ALK2 |
0.641 | 0.015 | -2 | 0.612 |
MSK2 |
0.641 | -0.005 | -3 | 0.326 |
HIPK1 |
0.641 | 0.071 | 1 | 0.549 |
AURB |
0.641 | 0.075 | -2 | 0.459 |
GAK |
0.640 | 0.110 | 1 | 0.699 |
NEK6 |
0.640 | -0.046 | -2 | 0.647 |
GRK4 |
0.639 | -0.035 | -2 | 0.716 |
ALK4 |
0.639 | -0.036 | -2 | 0.623 |
SBK |
0.639 | 0.052 | -3 | 0.331 |
PLK3 |
0.639 | -0.006 | 2 | 0.514 |
MAPKAPK3 |
0.639 | 0.032 | -3 | 0.433 |
CDK8 |
0.638 | 0.005 | 1 | 0.549 |
MLK2 |
0.638 | -0.089 | 2 | 0.458 |
MRCKA |
0.638 | 0.134 | -3 | 0.431 |
FAM20C |
0.638 | -0.015 | 2 | 0.323 |
CAMK2D |
0.638 | -0.015 | -3 | 0.408 |
RIPK1 |
0.638 | -0.029 | 1 | 0.579 |
MLK1 |
0.638 | -0.078 | 2 | 0.438 |
AKT1 |
0.638 | 0.082 | -3 | 0.411 |
TAO3 |
0.638 | 0.104 | 1 | 0.573 |
CLK4 |
0.637 | 0.072 | -3 | 0.395 |
AURA |
0.637 | 0.033 | -2 | 0.432 |
PAK3 |
0.637 | 0.041 | -2 | 0.616 |
IKKE |
0.637 | -0.086 | 1 | 0.474 |
PKCD |
0.637 | 0.023 | 2 | 0.417 |
CDK5 |
0.637 | 0.028 | 1 | 0.601 |
CAMK1G |
0.637 | 0.052 | -3 | 0.381 |
RSK3 |
0.637 | 0.004 | -3 | 0.392 |
VRK2 |
0.637 | -0.097 | 1 | 0.652 |
CK2A1 |
0.636 | 0.077 | 1 | 0.724 |
MEK1 |
0.636 | -0.099 | 2 | 0.512 |
DMPK1 |
0.636 | 0.157 | -3 | 0.478 |
PKACA |
0.636 | 0.067 | -2 | 0.410 |
PAK2 |
0.636 | 0.032 | -2 | 0.612 |
CDK7 |
0.636 | 0.018 | 1 | 0.579 |
CDK18 |
0.636 | 0.028 | 1 | 0.519 |
MPSK1 |
0.635 | 0.051 | 1 | 0.657 |
CDK16 |
0.635 | 0.048 | 1 | 0.499 |
CLK1 |
0.635 | 0.097 | -3 | 0.432 |
PLK1 |
0.635 | -0.025 | -2 | 0.603 |
PRKD3 |
0.635 | 0.036 | -3 | 0.424 |
GRK3 |
0.635 | 0.030 | -2 | 0.602 |
PRP4 |
0.635 | -0.039 | -3 | 0.273 |
CDK1 |
0.635 | 0.024 | 1 | 0.552 |
HIPK2 |
0.635 | 0.048 | 1 | 0.481 |
PDHK1 |
0.634 | -0.210 | 1 | 0.599 |
SNRK |
0.634 | 0.033 | 2 | 0.462 |
DNAPK |
0.634 | -0.016 | 1 | 0.500 |
DYRK1A |
0.634 | 0.016 | 1 | 0.592 |
CDK17 |
0.633 | 0.025 | 1 | 0.478 |
DCAMKL2 |
0.633 | 0.089 | -3 | 0.516 |
P38A |
0.633 | 0.006 | 1 | 0.576 |
PKR |
0.633 | -0.046 | 1 | 0.628 |
NEK7 |
0.633 | -0.124 | -3 | 0.325 |
MAK |
0.633 | 0.061 | -2 | 0.571 |
MLK3 |
0.633 | -0.049 | 2 | 0.381 |
JNK1 |
0.633 | 0.030 | 1 | 0.526 |
GCN2 |
0.633 | -0.120 | 2 | 0.471 |
LKB1 |
0.633 | -0.015 | -3 | 0.355 |
SMMLCK |
0.633 | 0.032 | -3 | 0.386 |
ROCK2 |
0.633 | 0.124 | -3 | 0.452 |
ANKRD3 |
0.632 | -0.121 | 1 | 0.624 |
ULK2 |
0.632 | -0.151 | 2 | 0.449 |
CDK14 |
0.632 | 0.046 | 1 | 0.536 |
P38B |
0.632 | 0.007 | 1 | 0.521 |
P38G |
0.632 | 0.016 | 1 | 0.462 |
SRPK2 |
0.632 | 0.008 | -3 | 0.294 |
MLK4 |
0.632 | -0.044 | 2 | 0.396 |
CDK19 |
0.631 | 0.007 | 1 | 0.513 |
PLK2 |
0.631 | 0.014 | -3 | 0.347 |
DYRK3 |
0.631 | 0.053 | 1 | 0.528 |
SGK1 |
0.631 | 0.036 | -3 | 0.314 |
SRPK3 |
0.631 | 0.001 | -3 | 0.299 |
P70S6K |
0.631 | 0.021 | -3 | 0.329 |
ACVR2A |
0.631 | -0.044 | -2 | 0.551 |
PKCG |
0.630 | 0.032 | 2 | 0.380 |
MOK |
0.630 | 0.105 | 1 | 0.560 |
MST3 |
0.630 | 0.040 | 2 | 0.472 |
PAK6 |
0.630 | 0.110 | -2 | 0.561 |
TLK2 |
0.630 | -0.074 | 1 | 0.619 |
MNK2 |
0.630 | 0.074 | -2 | 0.584 |
PINK1 |
0.630 | -0.059 | 1 | 0.709 |
ERK2 |
0.630 | -0.000 | 1 | 0.546 |
MRCKB |
0.630 | 0.099 | -3 | 0.422 |
PKCB |
0.630 | 0.015 | 2 | 0.377 |
ERK1 |
0.629 | 0.005 | 1 | 0.511 |
PKG2 |
0.629 | 0.051 | -2 | 0.479 |
WNK4 |
0.629 | 0.040 | -2 | 0.716 |
YSK4 |
0.628 | -0.105 | 1 | 0.540 |
CK1E |
0.628 | -0.023 | -3 | 0.171 |
PKCA |
0.628 | 0.000 | 2 | 0.356 |
IRE1 |
0.627 | -0.027 | 1 | 0.581 |
MEK5 |
0.627 | -0.093 | 2 | 0.486 |
NEK9 |
0.627 | -0.168 | 2 | 0.447 |
MEKK3 |
0.626 | -0.045 | 1 | 0.560 |
GCK |
0.626 | 0.040 | 1 | 0.587 |
CDK10 |
0.626 | 0.062 | 1 | 0.534 |
PKCZ |
0.626 | -0.009 | 2 | 0.410 |
TGFBR2 |
0.626 | -0.096 | -2 | 0.552 |
CAMK1A |
0.626 | 0.047 | -3 | 0.414 |
P38D |
0.626 | 0.011 | 1 | 0.478 |
IRE2 |
0.625 | -0.026 | 2 | 0.423 |
PBK |
0.625 | 0.043 | 1 | 0.619 |
PKCH |
0.625 | 0.004 | 2 | 0.362 |
CK1D |
0.625 | -0.035 | -3 | 0.140 |
NEK5 |
0.624 | -0.090 | 1 | 0.615 |
SMG1 |
0.624 | -0.081 | 1 | 0.609 |
TTBK2 |
0.624 | -0.105 | 2 | 0.403 |
AKT3 |
0.624 | 0.034 | -3 | 0.338 |
HIPK3 |
0.623 | 0.014 | 1 | 0.521 |
KIS |
0.623 | 0.009 | 1 | 0.558 |
CAMKK1 |
0.623 | -0.087 | -2 | 0.677 |
CDK13 |
0.623 | -0.026 | 1 | 0.546 |
BCKDK |
0.623 | -0.144 | -1 | 0.633 |
CRIK |
0.623 | 0.060 | -3 | 0.391 |
ULK1 |
0.622 | -0.161 | -3 | 0.292 |
TAO2 |
0.622 | 0.033 | 2 | 0.458 |
CHK2 |
0.622 | 0.038 | -3 | 0.371 |
MEKK2 |
0.622 | -0.096 | 2 | 0.451 |
CAMKK2 |
0.621 | -0.074 | -2 | 0.654 |
ROCK1 |
0.621 | 0.109 | -3 | 0.427 |
MEKK1 |
0.621 | -0.149 | 1 | 0.557 |
PLK4 |
0.620 | -0.063 | 2 | 0.428 |
TAK1 |
0.620 | -0.024 | 1 | 0.678 |
CHAK1 |
0.620 | -0.095 | 2 | 0.433 |
PHKG1 |
0.619 | 0.012 | -3 | 0.467 |
ZAK |
0.619 | -0.115 | 1 | 0.526 |
ALPHAK3 |
0.619 | 0.135 | -1 | 0.762 |
PDK1 |
0.619 | -0.055 | 1 | 0.594 |
TLK1 |
0.619 | -0.087 | -2 | 0.624 |
LRRK2 |
0.618 | -0.017 | 2 | 0.479 |
CDK9 |
0.618 | -0.020 | 1 | 0.539 |
NEK8 |
0.618 | -0.093 | 2 | 0.461 |
CDK12 |
0.617 | -0.023 | 1 | 0.514 |
IRAK4 |
0.617 | -0.034 | 1 | 0.559 |
VRK1 |
0.617 | -0.023 | 2 | 0.508 |
NEK11 |
0.617 | -0.088 | 1 | 0.566 |
PHKG2 |
0.616 | 0.102 | -3 | 0.502 |
CDK2 |
0.616 | -0.045 | 1 | 0.598 |
HPK1 |
0.616 | 0.011 | 1 | 0.548 |
HRI |
0.615 | -0.117 | -2 | 0.627 |
CDK3 |
0.615 | 0.001 | 1 | 0.502 |
NEK2 |
0.614 | -0.166 | 2 | 0.437 |
PERK |
0.614 | -0.139 | -2 | 0.639 |
TNIK |
0.613 | -0.020 | 3 | 0.638 |
CK1A2 |
0.613 | -0.062 | -3 | 0.142 |
ERK7 |
0.612 | -0.044 | 2 | 0.243 |
MAP3K15 |
0.612 | -0.075 | 1 | 0.514 |
PKCT |
0.612 | -0.021 | 2 | 0.370 |
MST2 |
0.611 | -0.126 | 1 | 0.574 |
PAK5 |
0.611 | 0.047 | -2 | 0.491 |
CDK4 |
0.611 | 0.015 | 1 | 0.506 |
SLK |
0.610 | -0.003 | -2 | 0.578 |
PKCE |
0.610 | 0.018 | 2 | 0.359 |
KHS1 |
0.610 | -0.006 | 1 | 0.520 |
KHS2 |
0.609 | 0.019 | 1 | 0.550 |
MEKK6 |
0.609 | -0.090 | 1 | 0.557 |
CDK6 |
0.609 | 0.002 | 1 | 0.518 |
IRAK1 |
0.607 | -0.142 | -1 | 0.561 |
MST1 |
0.607 | -0.089 | 1 | 0.538 |
BUB1 |
0.607 | 0.006 | -5 | 0.523 |
NEK1 |
0.607 | -0.106 | 1 | 0.556 |
PKN1 |
0.607 | -0.001 | -3 | 0.369 |
LOK |
0.606 | -0.018 | -2 | 0.609 |
HGK |
0.606 | -0.088 | 3 | 0.647 |
PAK4 |
0.605 | 0.034 | -2 | 0.478 |
MINK |
0.605 | -0.111 | 1 | 0.542 |
EEF2K |
0.604 | -0.088 | 3 | 0.605 |
NEK4 |
0.604 | -0.146 | 1 | 0.530 |
PKCI |
0.603 | -0.037 | 2 | 0.377 |
OSR1 |
0.602 | -0.058 | 2 | 0.435 |
YSK1 |
0.601 | -0.071 | 2 | 0.422 |
MAPKAPK5 |
0.601 | -0.126 | -3 | 0.268 |
MEK2 |
0.601 | -0.192 | 2 | 0.483 |
HASPIN |
0.600 | 0.024 | -1 | 0.584 |
YANK3 |
0.599 | -0.054 | 2 | 0.261 |
ASK1 |
0.598 | -0.086 | 1 | 0.509 |
RIPK2 |
0.596 | -0.132 | 1 | 0.489 |
STK33 |
0.596 | -0.103 | 2 | 0.357 |
TTK |
0.595 | -0.073 | -2 | 0.592 |
BIKE |
0.595 | -0.012 | 1 | 0.591 |
TTBK1 |
0.595 | -0.136 | 2 | 0.363 |
TAO1 |
0.594 | -0.002 | 1 | 0.464 |
CK1A |
0.593 | -0.048 | -3 | 0.104 |
CK1G1 |
0.593 | -0.105 | -3 | 0.172 |
MYO3B |
0.592 | -0.075 | 2 | 0.449 |
MYO3A |
0.591 | -0.071 | 1 | 0.513 |
PKG1 |
0.589 | -0.013 | -2 | 0.393 |
STLK3 |
0.581 | -0.145 | 1 | 0.489 |
AAK1 |
0.580 | -0.001 | 1 | 0.511 |
PDHK3_TYR |
0.577 | 0.197 | 4 | 0.623 |
NEK3 |
0.577 | -0.218 | 1 | 0.490 |
YANK2 |
0.576 | -0.064 | 2 | 0.241 |
PDHK4_TYR |
0.576 | 0.185 | 2 | 0.578 |
CK1G3 |
0.570 | -0.083 | -3 | 0.090 |
MAP2K6_TYR |
0.569 | 0.102 | -1 | 0.736 |
CK1G2 |
0.569 | -0.037 | -3 | 0.140 |
TESK1_TYR |
0.566 | 0.081 | 3 | 0.715 |
MAP2K4_TYR |
0.565 | 0.050 | -1 | 0.741 |
BMPR2_TYR |
0.564 | 0.050 | -1 | 0.734 |
PDHK1_TYR |
0.563 | 0.035 | -1 | 0.724 |
MAP2K7_TYR |
0.562 | 0.016 | 2 | 0.538 |
PKMYT1_TYR |
0.562 | 0.016 | 3 | 0.690 |
LIMK2_TYR |
0.561 | 0.090 | -3 | 0.437 |
TXK |
0.560 | 0.073 | 1 | 0.734 |
FER |
0.559 | 0.038 | 1 | 0.741 |
EPHB4 |
0.557 | 0.021 | -1 | 0.711 |
PINK1_TYR |
0.557 | 0.018 | 1 | 0.671 |
INSRR |
0.557 | 0.033 | 3 | 0.651 |
EPHA6 |
0.556 | 0.027 | -1 | 0.710 |
LIMK1_TYR |
0.556 | 0.006 | 2 | 0.492 |
BMX |
0.555 | 0.116 | -1 | 0.691 |
EPHA4 |
0.554 | 0.011 | 2 | 0.523 |
DDR1 |
0.553 | 0.024 | 4 | 0.561 |
JAK3 |
0.551 | -0.000 | 1 | 0.565 |
ABL2 |
0.550 | 0.029 | -1 | 0.702 |
SRMS |
0.550 | -0.006 | 1 | 0.707 |
ROS1 |
0.549 | -0.030 | 3 | 0.664 |
TYRO3 |
0.549 | -0.036 | 3 | 0.669 |
EPHB1 |
0.549 | -0.020 | 1 | 0.667 |
EPHB2 |
0.548 | -0.013 | -1 | 0.684 |
RET |
0.548 | -0.032 | 1 | 0.553 |
MATK |
0.548 | 0.078 | -1 | 0.729 |
FGFR2 |
0.548 | 0.007 | 3 | 0.672 |
EPHB3 |
0.548 | -0.029 | -1 | 0.686 |
MERTK |
0.547 | 0.002 | 3 | 0.674 |
MST1R |
0.547 | -0.040 | 3 | 0.673 |
KDR |
0.546 | 0.038 | 3 | 0.641 |
EPHA5 |
0.546 | 0.021 | 2 | 0.524 |
ITK |
0.546 | 0.007 | -1 | 0.611 |
KIT |
0.546 | 0.007 | 3 | 0.670 |
TEK |
0.546 | -0.001 | 3 | 0.631 |
LTK |
0.546 | 0.047 | 3 | 0.633 |
ABL1 |
0.545 | -0.015 | -1 | 0.677 |
YES1 |
0.545 | -0.037 | -1 | 0.614 |
FGR |
0.545 | -0.057 | 1 | 0.683 |
CSF1R |
0.545 | -0.059 | 3 | 0.668 |
FGFR3 |
0.544 | 0.011 | 3 | 0.653 |
MET |
0.544 | 0.010 | 3 | 0.666 |
WEE1_TYR |
0.544 | 0.070 | -1 | 0.733 |
ALK |
0.544 | 0.027 | 3 | 0.622 |
TNK2 |
0.543 | -0.017 | 3 | 0.640 |
FGFR1 |
0.542 | -0.044 | 3 | 0.665 |
TYK2 |
0.542 | -0.119 | 1 | 0.547 |
SYK |
0.541 | 0.050 | -1 | 0.697 |
PTK6 |
0.541 | -0.024 | -1 | 0.648 |
INSR |
0.541 | -0.018 | 3 | 0.622 |
PTK2B |
0.540 | -0.006 | -1 | 0.590 |
DDR2 |
0.540 | 0.051 | 3 | 0.625 |
EPHA3 |
0.540 | -0.041 | 2 | 0.509 |
LCK |
0.539 | -0.042 | -1 | 0.615 |
EPHA7 |
0.539 | -0.031 | 2 | 0.502 |
BLK |
0.538 | -0.015 | -1 | 0.601 |
AXL |
0.538 | -0.048 | 3 | 0.684 |
NTRK1 |
0.538 | -0.058 | -1 | 0.751 |
FLT3 |
0.538 | -0.039 | 3 | 0.646 |
JAK2 |
0.538 | -0.146 | 1 | 0.539 |
NTRK3 |
0.537 | -0.011 | -1 | 0.780 |
FYN |
0.537 | -0.020 | -1 | 0.596 |
NEK10_TYR |
0.537 | -0.050 | 1 | 0.495 |
FLT1 |
0.536 | -0.021 | -1 | 0.718 |
HCK |
0.536 | -0.093 | -1 | 0.610 |
TEC |
0.536 | -0.019 | -1 | 0.576 |
PTK2 |
0.536 | 0.005 | -1 | 0.609 |
EPHA8 |
0.536 | -0.030 | -1 | 0.684 |
PDGFRB |
0.536 | -0.080 | 3 | 0.683 |
FLT4 |
0.534 | -0.022 | 3 | 0.636 |
TNK1 |
0.533 | -0.029 | 3 | 0.658 |
ERBB2 |
0.533 | -0.059 | 1 | 0.548 |
EPHA2 |
0.533 | -0.006 | -1 | 0.711 |
IGF1R |
0.531 | -0.005 | 3 | 0.580 |
NTRK2 |
0.531 | -0.083 | 3 | 0.652 |
EGFR |
0.531 | -0.025 | 1 | 0.472 |
CSK |
0.531 | -0.036 | 2 | 0.514 |
BTK |
0.530 | -0.094 | -1 | 0.582 |
FES |
0.530 | 0.030 | -1 | 0.676 |
FGFR4 |
0.530 | -0.009 | -1 | 0.743 |
TNNI3K_TYR |
0.529 | -0.091 | 1 | 0.538 |
ZAP70 |
0.529 | 0.059 | -1 | 0.734 |
FRK |
0.528 | -0.066 | -1 | 0.627 |
PDGFRA |
0.528 | -0.115 | 3 | 0.673 |
JAK1 |
0.528 | -0.088 | 1 | 0.465 |
EPHA1 |
0.526 | -0.080 | 3 | 0.650 |
LYN |
0.526 | -0.090 | 3 | 0.591 |
SRC |
0.524 | -0.073 | -1 | 0.593 |
ERBB4 |
0.522 | -0.036 | 1 | 0.524 |
MUSK |
0.517 | -0.040 | 1 | 0.460 |