Motif 130 (n=114)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4D1P6 | WDR91 | S256 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
| A6H8Y1 | BDP1 | S1621 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NCQ9 | RNF222 | S170 | ochoa | RING finger protein 222 | None |
| O15062 | ZBTB5 | S208 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15062 | ZBTB5 | S371 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15084 | ANKRD28 | S1011 | ochoa|psp | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651, ECO:0000269|PubMed:35512830}. |
| O15231 | ZNF185 | S231 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O15350 | TP73 | S426 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O15357 | INPPL1 | S916 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43164 | PJA2 | S253 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43379 | WDR62 | S1093 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O75128 | COBL | S282 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75145 | PPFIA3 | S645 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75170 | PPP6R2 | S427 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| O75376 | NCOR1 | S1381 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94823 | ATP10B | S1371 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O95171 | SCEL | S524 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95208 | EPN2 | S426 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| P12259 | F5 | S912 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P15036 | ETS2 | S248 | psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P15848 | ARSB | S409 | ochoa | Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}. |
| P16144 | ITGB4 | S1084 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P28908 | TNFRSF8 | S429 | ochoa | Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) | Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:8391931, ECO:0000269|PubMed:8999898}. |
| P38159 | RBMX | S215 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P46821 | MAP1B | S2007 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P55198 | MLLT6 | S563 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
| P85037 | FOXK1 | S488 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P98171 | ARHGAP4 | S410 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q01196 | RUNX1 | S225 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q03164 | KMT2A | S351 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05086 | UBE3A | S100 | ochoa | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}. |
| Q05397 | PTK2 | S580 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q12923 | PTPN13 | S215 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13625 | TP53BP2 | S458 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13761 | RUNX3 | S149 | psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13950 | RUNX2 | S196 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14162 | SCARF1 | S589 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14511 | NEDD9 | S182 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14676 | MDC1 | S1130 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1171 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1212 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1335 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1376 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1417 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1458 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1499 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1540 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1581 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1622 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15398 | DLGAP5 | S340 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15942 | ZYX | S169 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16600 | ZNF239 | S28 | ochoa | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| Q16891 | IMMT | S113 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q58DX5 | NAALADL2 | S104 | ochoa | Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2) | May be catalytically inactive. |
| Q5F1R6 | DNAJC21 | S436 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5JTV8 | TOR1AIP1 | S281 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5JTW2 | CEP78 | S644 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
| Q5SW79 | CEP170 | S252 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S257 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5VST9 | OBSCN | S6963 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VYS4 | MEDAG | S264 | ochoa | Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4) | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}. |
| Q68CP9 | ARID2 | S1476 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q6F5E8 | CARMIL2 | S1268 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ23 | PLEKHA7 | S463 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NV74 | CRACDL | S333 | ochoa | CRACD-like protein | None |
| Q6U841 | SLC4A10 | S238 | ochoa | Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) | Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000250|UniProtKB:Q80ZA5, ECO:0000269|PubMed:18319254}. |
| Q7Z333 | SETX | S1345 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z3K3 | POGZ | S1360 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q86V15 | CASZ1 | S213 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q8IXZ2 | ZC3H3 | S220 | ochoa | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. |
| Q8N4X5 | AFAP1L2 | S357 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8NF91 | SYNE1 | S8704 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TEK3 | DOT1L | S899 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEQ6 | GEMIN5 | S1417 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TEW0 | PARD3 | S174 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WXE9 | STON2 | S762 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q92622 | RUBCN | S266 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q96E39 | RBMXL1 | S215 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96F81 | DISP1 | S1380 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96JM2 | ZNF462 | S638 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96LC7 | SIGLEC10 | S645 | ochoa | Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q80ZE3, ECO:0000269|PubMed:11284738, ECO:0000269|PubMed:25450598, ECO:0000305|PubMed:12163025}. |
| Q96QZ7 | MAGI1 | S938 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q96S94 | CCNL2 | S338 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
| Q96T37 | RBM15 | S622 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q9BQ15 | NABP2 | S134 | psp | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}. |
| Q9BTC0 | DIDO1 | S114 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX66 | SORBS1 | S115 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BY89 | KIAA1671 | S590 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYW2 | SETD2 | S1263 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZF2 | OSBPL7 | S236 | ochoa | Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) | None |
| Q9C0C7 | AMBRA1 | S404 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9C0K1 | SLC39A8 | S275 | ochoa | Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) | Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:26637978, PubMed:29337306, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). {ECO:0000250|UniProtKB:Q91W10, ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:22898811, ECO:0000269|PubMed:23403290, ECO:0000269|PubMed:26637978, ECO:0000269|PubMed:27166256, ECO:0000269|PubMed:27466201, ECO:0000269|PubMed:28056086, ECO:0000269|PubMed:28481222, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:29453449, ECO:0000269|PubMed:29927450, ECO:0000269|PubMed:31699897}. |
| Q9H7U1 | CCSER2 | S223 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H8N7 | ZNF395 | S387 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9NP71 | MLXIPL | S631 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NRL2 | BAZ1A | S1296 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NVN8 | GNL3L | S214 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NXL9 | MCM9 | S663 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NXR8 | ING3 | S140 | ochoa | Inhibitor of growth protein 3 (p47ING3) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:12545155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9NY65 | TUBA8 | S287 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9UKA4 | AKAP11 | S1013 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKT8 | FBXW2 | S243 | ochoa | F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
| Q9ULC0 | EMCN | S117 | ochoa | Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14) | Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. |
| Q9ULJ7 | ANKRD50 | S1213 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9ULL1 | PLEKHG1 | S1128 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UPQ0 | LIMCH1 | S710 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y2J4 | AMOTL2 | S723 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y512 | SAMM50 | S189 | ochoa | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}. |
| O00506 | STK25 | S342 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| O14744 | PRMT5 | S463 | Sugiyama | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| P53621 | COPA | S266 | Sugiyama | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P53609 | PGGT1B | S347 | Sugiyama | Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}. |
| Q15365 | PCBP1 | S141 | Sugiyama | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S141 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000004 | 5.420 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.000013 | 4.896 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000076 | 4.118 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000146 | 3.834 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.001220 | 2.914 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.002128 | 2.672 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.002454 | 2.610 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.002540 | 2.595 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.003610 | 2.442 |
| R-HSA-4839726 | Chromatin organization | 0.003478 | 2.459 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.004720 | 2.326 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.005224 | 2.282 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.006108 | 2.214 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.007993 | 2.097 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.007659 | 2.116 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.006863 | 2.163 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.007659 | 2.116 |
| R-HSA-9945266 | Differentiation of T cells | 0.009367 | 2.028 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.009367 | 2.028 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.013923 | 1.856 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.016050 | 1.795 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.042309 | 1.374 |
| R-HSA-2206285 | MPS VI - Maroteaux-Lamy syndrome | 0.042309 | 1.374 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.049186 | 1.308 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.049186 | 1.308 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.056013 | 1.252 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.056013 | 1.252 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.056013 | 1.252 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.062793 | 1.202 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.069524 | 1.158 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.076207 | 1.118 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.095972 | 1.018 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.102466 | 0.989 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.108915 | 0.963 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.115317 | 0.938 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.127986 | 0.893 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.032611 | 1.487 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.134253 | 0.872 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.146652 | 0.834 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.194515 | 0.711 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.206058 | 0.686 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.104587 | 0.981 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.287564 | 0.541 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.155053 | 0.810 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.022678 | 1.644 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.029331 | 1.533 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.199035 | 0.701 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.038919 | 1.410 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.206058 | 0.686 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.069524 | 1.158 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.025365 | 1.596 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.127986 | 0.893 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.084664 | 1.072 |
| R-HSA-191859 | snRNP Assembly | 0.084664 | 1.072 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.056013 | 1.252 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.069524 | 1.158 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.076207 | 1.118 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.140475 | 0.852 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.176886 | 0.752 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.182805 | 0.738 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.108915 | 0.963 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.282399 | 0.549 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.228656 | 0.641 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.266678 | 0.574 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.109174 | 0.962 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.062793 | 1.202 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.121674 | 0.915 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.164922 | 0.783 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.327584 | 0.485 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.323081 | 0.491 |
| R-HSA-72172 | mRNA Splicing | 0.219456 | 0.659 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.069524 | 1.158 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.182805 | 0.738 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.266678 | 0.574 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.180473 | 0.744 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.292693 | 0.534 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.180473 | 0.744 |
| R-HSA-8949613 | Cristae formation | 0.024006 | 1.620 |
| R-HSA-1663150 | The activation of arylsulfatases | 0.121674 | 0.915 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.146652 | 0.834 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.152786 | 0.816 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.182805 | 0.738 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.250616 | 0.601 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.031994 | 1.495 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.201232 | 0.696 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.054610 | 1.263 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.228656 | 0.641 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.288664 | 0.540 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.174316 | 0.759 |
| R-HSA-8875878 | MET promotes cell motility | 0.277196 | 0.557 |
| R-HSA-9909396 | Circadian clock | 0.288664 | 0.540 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.182805 | 0.738 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.102466 | 0.989 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.152786 | 0.816 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.170926 | 0.767 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.194515 | 0.711 |
| R-HSA-1221632 | Meiotic synapsis | 0.072121 | 1.142 |
| R-HSA-420029 | Tight junction interactions | 0.200307 | 0.698 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.217438 | 0.663 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.234205 | 0.630 |
| R-HSA-354192 | Integrin signaling | 0.245185 | 0.611 |
| R-HSA-391251 | Protein folding | 0.167678 | 0.776 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.076379 | 1.117 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.332427 | 0.478 |
| R-HSA-212436 | Generic Transcription Pathway | 0.059021 | 1.229 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.127986 | 0.893 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.317793 | 0.498 |
| R-HSA-373752 | Netrin-1 signaling | 0.312845 | 0.505 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.066186 | 1.179 |
| R-HSA-9646399 | Aggrephagy | 0.287564 | 0.541 |
| R-HSA-74160 | Gene expression (Transcription) | 0.121997 | 0.914 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.069524 | 1.158 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.082842 | 1.082 |
| R-HSA-425381 | Bicarbonate transporters | 0.095972 | 1.018 |
| R-HSA-429947 | Deadenylation of mRNA | 0.194515 | 0.711 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.206058 | 0.686 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.282399 | 0.549 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.164922 | 0.783 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.261362 | 0.583 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.256008 | 0.592 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.108915 | 0.963 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.108915 | 0.963 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.108915 | 0.963 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.200307 | 0.698 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.200307 | 0.698 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.217438 | 0.663 |
| R-HSA-9930044 | Nuclear RNA decay | 0.245185 | 0.611 |
| R-HSA-190861 | Gap junction assembly | 0.256008 | 0.592 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.024705 | 1.607 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.287564 | 0.541 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.082842 | 1.082 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.134253 | 0.872 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.140475 | 0.852 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.152786 | 0.816 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.188681 | 0.724 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.234205 | 0.630 |
| R-HSA-2024101 | CS/DS degradation | 0.250616 | 0.601 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.024006 | 1.620 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.152551 | 0.817 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.234205 | 0.630 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.312845 | 0.505 |
| R-HSA-190828 | Gap junction trafficking | 0.312845 | 0.505 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.120867 | 0.918 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.228656 | 0.641 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.245185 | 0.611 |
| R-HSA-437239 | Recycling pathway of L1 | 0.327584 | 0.485 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.099990 | 1.000 |
| R-HSA-2028269 | Signaling by Hippo | 0.146652 | 0.834 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.261362 | 0.583 |
| R-HSA-1500620 | Meiosis | 0.145096 | 0.838 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.134253 | 0.872 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.266678 | 0.574 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.091167 | 1.040 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.239715 | 0.620 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.017688 | 1.752 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.028175 | 1.550 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.121674 | 0.915 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.070095 | 1.154 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.028175 | 1.550 |
| R-HSA-2206281 | Mucopolysaccharidoses | 0.228656 | 0.641 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.183050 | 0.737 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.297785 | 0.526 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.188681 | 0.724 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.245185 | 0.611 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.271956 | 0.566 |
| R-HSA-1632852 | Macroautophagy | 0.315168 | 0.501 |
| R-HSA-435354 | Zinc transporters | 0.121674 | 0.915 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.194515 | 0.711 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.332404 | 0.478 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.182805 | 0.738 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.245185 | 0.611 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.062411 | 1.205 |
| R-HSA-3000170 | Syndecan interactions | 0.188681 | 0.724 |
| R-HSA-3000157 | Laminin interactions | 0.200307 | 0.698 |
| R-HSA-2559583 | Cellular Senescence | 0.173790 | 0.760 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.209090 | 0.680 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.091167 | 1.040 |
| R-HSA-1500931 | Cell-Cell communication | 0.224256 | 0.649 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.069488 | 1.158 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.076231 | 1.118 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.277196 | 0.557 |
| R-HSA-1474165 | Reproduction | 0.283347 | 0.548 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.137903 | 0.860 |
| R-HSA-425410 | Metal ion SLC transporters | 0.332427 | 0.478 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.078313 | 1.106 |
| R-HSA-2172127 | DAP12 interactions | 0.312845 | 0.505 |
| R-HSA-157118 | Signaling by NOTCH | 0.119155 | 0.924 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.239715 | 0.620 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.302841 | 0.519 |
| R-HSA-1483255 | PI Metabolism | 0.196014 | 0.708 |
| R-HSA-109581 | Apoptosis | 0.141203 | 0.850 |
| R-HSA-75153 | Apoptotic execution phase | 0.322706 | 0.491 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.287564 | 0.541 |
| R-HSA-5357801 | Programmed Cell Death | 0.221334 | 0.655 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.035097 | 1.455 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.337235 | 0.472 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.337235 | 0.472 |
| R-HSA-199991 | Membrane Trafficking | 0.351649 | 0.454 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.351888 | 0.454 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.356128 | 0.448 |
| R-HSA-9612973 | Autophagy | 0.357084 | 0.447 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.360767 | 0.443 |
| R-HSA-446728 | Cell junction organization | 0.363320 | 0.440 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.365279 | 0.437 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.365373 | 0.437 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.365373 | 0.437 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.365373 | 0.437 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.367430 | 0.435 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.369947 | 0.432 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.369947 | 0.432 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.374487 | 0.427 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.378995 | 0.421 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.378995 | 0.421 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.383471 | 0.416 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.383471 | 0.416 |
| R-HSA-180786 | Extension of Telomeres | 0.383471 | 0.416 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.383471 | 0.416 |
| R-HSA-983189 | Kinesins | 0.387915 | 0.411 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.387915 | 0.411 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.387915 | 0.411 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.387915 | 0.411 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.387915 | 0.411 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.387915 | 0.411 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.387915 | 0.411 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.389010 | 0.410 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.396107 | 0.402 |
| R-HSA-9707616 | Heme signaling | 0.396707 | 0.402 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.396707 | 0.402 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.396707 | 0.402 |
| R-HSA-1268020 | Mitochondrial protein import | 0.396707 | 0.402 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.401057 | 0.397 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.401057 | 0.397 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.405375 | 0.392 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.408136 | 0.389 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.413919 | 0.383 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.413919 | 0.383 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.418145 | 0.379 |
| R-HSA-8953854 | Metabolism of RNA | 0.421088 | 0.376 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.422341 | 0.374 |
| R-HSA-1640170 | Cell Cycle | 0.429067 | 0.367 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.430643 | 0.366 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.434750 | 0.362 |
| R-HSA-69275 | G2/M Transition | 0.435390 | 0.361 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.440274 | 0.356 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.442875 | 0.354 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.442875 | 0.354 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.442875 | 0.354 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.442875 | 0.354 |
| R-HSA-5617833 | Cilium Assembly | 0.445136 | 0.352 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.446894 | 0.350 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.446894 | 0.350 |
| R-HSA-380287 | Centrosome maturation | 0.450885 | 0.346 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.450885 | 0.346 |
| R-HSA-68877 | Mitotic Prometaphase | 0.452384 | 0.344 |
| R-HSA-5689603 | UCH proteinases | 0.454847 | 0.342 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.454847 | 0.342 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.458780 | 0.338 |
| R-HSA-9609690 | HCMV Early Events | 0.459580 | 0.338 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.462686 | 0.335 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.462686 | 0.335 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.469089 | 0.329 |
| R-HSA-6806834 | Signaling by MET | 0.470413 | 0.328 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.470413 | 0.328 |
| R-HSA-9833482 | PKR-mediated signaling | 0.470413 | 0.328 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.474235 | 0.324 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.474235 | 0.324 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.481798 | 0.317 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.481798 | 0.317 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.485538 | 0.314 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.489252 | 0.310 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.496600 | 0.304 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.496600 | 0.304 |
| R-HSA-449147 | Signaling by Interleukins | 0.499262 | 0.302 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.500235 | 0.301 |
| R-HSA-9663891 | Selective autophagy | 0.503844 | 0.298 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.510984 | 0.292 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.510984 | 0.292 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.514516 | 0.289 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.514516 | 0.289 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.521504 | 0.283 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.522917 | 0.282 |
| R-HSA-1474290 | Collagen formation | 0.528392 | 0.277 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.531799 | 0.274 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.538540 | 0.269 |
| R-HSA-157579 | Telomere Maintenance | 0.541875 | 0.266 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.545185 | 0.263 |
| R-HSA-3214847 | HATs acetylate histones | 0.548472 | 0.261 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.548472 | 0.261 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.548472 | 0.261 |
| R-HSA-8939211 | ESR-mediated signaling | 0.554253 | 0.256 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.554975 | 0.256 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.558192 | 0.253 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.564556 | 0.248 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.567704 | 0.246 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.567704 | 0.246 |
| R-HSA-9833110 | RSV-host interactions | 0.567704 | 0.246 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.580072 | 0.237 |
| R-HSA-9609646 | HCMV Infection | 0.581119 | 0.236 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.582266 | 0.235 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.583109 | 0.234 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.586124 | 0.232 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.592089 | 0.228 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.595040 | 0.225 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.597969 | 0.223 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.597969 | 0.223 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.600878 | 0.221 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.606632 | 0.217 |
| R-HSA-373760 | L1CAM interactions | 0.609478 | 0.215 |
| R-HSA-5693538 | Homology Directed Repair | 0.615110 | 0.211 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.623407 | 0.205 |
| R-HSA-73886 | Chromosome Maintenance | 0.623407 | 0.205 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.627581 | 0.202 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.628839 | 0.201 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.628839 | 0.201 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.628839 | 0.201 |
| R-HSA-194138 | Signaling by VEGF | 0.636842 | 0.196 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.636842 | 0.196 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
| R-HSA-114608 | Platelet degranulation | 0.642082 | 0.192 |
| R-HSA-69481 | G2/M Checkpoints | 0.642082 | 0.192 |
| R-HSA-1280218 | Adaptive Immune System | 0.654460 | 0.184 |
| R-HSA-9843745 | Adipogenesis | 0.654857 | 0.184 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.659839 | 0.181 |
| R-HSA-1483257 | Phospholipid metabolism | 0.664908 | 0.177 |
| R-HSA-163685 | Integration of energy metabolism | 0.669591 | 0.174 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.669591 | 0.174 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.671985 | 0.173 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.679066 | 0.168 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.679066 | 0.168 |
| R-HSA-9664407 | Parasite infection | 0.679066 | 0.168 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.681126 | 0.167 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.681392 | 0.167 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.703754 | 0.153 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.709969 | 0.149 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.709969 | 0.149 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.710155 | 0.149 |
| R-HSA-9609507 | Protein localization | 0.710155 | 0.149 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.712257 | 0.147 |
| R-HSA-73887 | Death Receptor Signaling | 0.712257 | 0.147 |
| R-HSA-1989781 | PPARA activates gene expression | 0.714345 | 0.146 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.718475 | 0.144 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.732470 | 0.135 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.749455 | 0.125 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.753082 | 0.123 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.754876 | 0.122 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.768769 | 0.114 |
| R-HSA-983712 | Ion channel transport | 0.778673 | 0.109 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.785042 | 0.105 |
| R-HSA-9679506 | SARS-CoV Infections | 0.788260 | 0.103 |
| R-HSA-68886 | M Phase | 0.789724 | 0.103 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.795752 | 0.099 |
| R-HSA-428157 | Sphingolipid metabolism | 0.797238 | 0.098 |
| R-HSA-168256 | Immune System | 0.811192 | 0.091 |
| R-HSA-397014 | Muscle contraction | 0.814258 | 0.089 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.814258 | 0.089 |
| R-HSA-68882 | Mitotic Anaphase | 0.819610 | 0.086 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.820924 | 0.086 |
| R-HSA-8951664 | Neddylation | 0.826086 | 0.083 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.834767 | 0.078 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.835972 | 0.078 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.839373 | 0.076 |
| R-HSA-9824446 | Viral Infection Pathways | 0.842123 | 0.075 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.852571 | 0.069 |
| R-HSA-162582 | Signal Transduction | 0.855891 | 0.068 |
| R-HSA-421270 | Cell-cell junction organization | 0.860375 | 0.065 |
| R-HSA-5688426 | Deubiquitination | 0.864408 | 0.063 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.865399 | 0.063 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.867357 | 0.062 |
| R-HSA-112316 | Neuronal System | 0.870488 | 0.060 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.872131 | 0.059 |
| R-HSA-2262752 | Cellular responses to stress | 0.875216 | 0.058 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.876735 | 0.057 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.887950 | 0.052 |
| R-HSA-9658195 | Leishmania infection | 0.887950 | 0.052 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.894343 | 0.048 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.899639 | 0.046 |
| R-HSA-195721 | Signaling by WNT | 0.901103 | 0.045 |
| R-HSA-422475 | Axon guidance | 0.917671 | 0.037 |
| R-HSA-8957322 | Metabolism of steroids | 0.918316 | 0.037 |
| R-HSA-1474244 | Extracellular matrix organization | 0.922419 | 0.035 |
| R-HSA-597592 | Post-translational protein modification | 0.926175 | 0.033 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.927434 | 0.033 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.931047 | 0.031 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.932056 | 0.031 |
| R-HSA-109582 | Hemostasis | 0.933286 | 0.030 |
| R-HSA-9675108 | Nervous system development | 0.934134 | 0.030 |
| R-HSA-382551 | Transport of small molecules | 0.934970 | 0.029 |
| R-HSA-73894 | DNA Repair | 0.937350 | 0.028 |
| R-HSA-913531 | Interferon Signaling | 0.947524 | 0.023 |
| R-HSA-5668914 | Diseases of metabolism | 0.962106 | 0.017 |
| R-HSA-5663205 | Infectious disease | 0.969117 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.969212 | 0.014 |
| R-HSA-6798695 | Neutrophil degranulation | 0.969666 | 0.013 |
| R-HSA-1266738 | Developmental Biology | 0.978092 | 0.010 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.980295 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.986938 | 0.006 |
| R-HSA-168249 | Innate Immune System | 0.989845 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 0.997186 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.997750 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998502 | 0.001 |
| R-HSA-1643685 | Disease | 0.999793 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.852 | 0.264 | 1 | 0.758 |
RSK2 |
0.852 | 0.245 | -3 | 0.757 |
PIM3 |
0.849 | 0.210 | -3 | 0.784 |
MAPKAPK2 |
0.848 | 0.237 | -3 | 0.727 |
NDR2 |
0.848 | 0.178 | -3 | 0.786 |
PRKD1 |
0.848 | 0.234 | -3 | 0.776 |
P90RSK |
0.847 | 0.227 | -3 | 0.755 |
COT |
0.847 | 0.120 | 2 | 0.789 |
CAMK2D |
0.846 | 0.235 | -3 | 0.790 |
CAMK2B |
0.844 | 0.253 | 2 | 0.775 |
CAMK2A |
0.843 | 0.242 | 2 | 0.800 |
PRKD2 |
0.843 | 0.199 | -3 | 0.747 |
LATS2 |
0.842 | 0.163 | -5 | 0.772 |
MAPKAPK3 |
0.842 | 0.191 | -3 | 0.755 |
SKMLCK |
0.842 | 0.256 | -2 | 0.878 |
PIM1 |
0.842 | 0.215 | -3 | 0.741 |
RSK3 |
0.841 | 0.173 | -3 | 0.746 |
CLK2 |
0.839 | 0.286 | -3 | 0.719 |
RSK4 |
0.839 | 0.237 | -3 | 0.733 |
PKN3 |
0.839 | 0.152 | -3 | 0.774 |
MSK1 |
0.839 | 0.239 | -3 | 0.732 |
CAMK1B |
0.838 | 0.158 | -3 | 0.800 |
SRPK1 |
0.838 | 0.168 | -3 | 0.726 |
NDR1 |
0.837 | 0.121 | -3 | 0.791 |
HIPK4 |
0.836 | 0.151 | 1 | 0.750 |
ATR |
0.835 | 0.144 | 1 | 0.822 |
MTOR |
0.835 | 0.010 | 1 | 0.772 |
CAMK2G |
0.834 | 0.045 | 2 | 0.779 |
PKACB |
0.834 | 0.225 | -2 | 0.755 |
PKCD |
0.833 | 0.155 | 2 | 0.690 |
CAMLCK |
0.833 | 0.187 | -2 | 0.869 |
PKACG |
0.832 | 0.148 | -2 | 0.784 |
IKKB |
0.832 | -0.008 | -2 | 0.690 |
DSTYK |
0.832 | 0.054 | 2 | 0.824 |
CDC7 |
0.832 | -0.016 | 1 | 0.740 |
MSK2 |
0.832 | 0.167 | -3 | 0.714 |
PRPK |
0.832 | -0.069 | -1 | 0.851 |
TBK1 |
0.831 | -0.012 | 1 | 0.763 |
RAF1 |
0.831 | 0.026 | 1 | 0.812 |
SRPK2 |
0.831 | 0.147 | -3 | 0.669 |
CLK4 |
0.831 | 0.209 | -3 | 0.732 |
WNK1 |
0.830 | 0.054 | -2 | 0.870 |
P70S6KB |
0.830 | 0.131 | -3 | 0.769 |
CDKL1 |
0.830 | 0.095 | -3 | 0.768 |
PKN2 |
0.830 | 0.106 | -3 | 0.782 |
AURC |
0.829 | 0.187 | -2 | 0.736 |
CLK1 |
0.829 | 0.194 | -3 | 0.724 |
IKKE |
0.829 | -0.013 | 1 | 0.763 |
NLK |
0.829 | 0.051 | 1 | 0.806 |
PDHK4 |
0.829 | -0.130 | 1 | 0.820 |
ICK |
0.829 | 0.136 | -3 | 0.790 |
DAPK2 |
0.828 | 0.177 | -3 | 0.806 |
LATS1 |
0.828 | 0.227 | -3 | 0.810 |
NUAK2 |
0.828 | 0.084 | -3 | 0.786 |
PRKX |
0.828 | 0.214 | -3 | 0.683 |
MARK4 |
0.827 | 0.062 | 4 | 0.806 |
PAK1 |
0.827 | 0.139 | -2 | 0.840 |
TGFBR2 |
0.827 | 0.022 | -2 | 0.767 |
NIK |
0.826 | 0.077 | -3 | 0.802 |
AMPKA1 |
0.826 | 0.085 | -3 | 0.791 |
TSSK1 |
0.825 | 0.130 | -3 | 0.802 |
MOS |
0.825 | -0.038 | 1 | 0.746 |
DYRK2 |
0.825 | 0.136 | 1 | 0.682 |
AMPKA2 |
0.825 | 0.108 | -3 | 0.780 |
ULK2 |
0.825 | -0.081 | 2 | 0.670 |
DNAPK |
0.825 | 0.168 | 1 | 0.777 |
GCN2 |
0.825 | -0.155 | 2 | 0.710 |
IKKA |
0.825 | 0.041 | -2 | 0.673 |
BMPR2 |
0.824 | -0.096 | -2 | 0.845 |
PDHK1 |
0.824 | -0.112 | 1 | 0.820 |
PAK3 |
0.824 | 0.109 | -2 | 0.836 |
RIPK3 |
0.824 | -0.001 | 3 | 0.733 |
PRKD3 |
0.824 | 0.125 | -3 | 0.718 |
MNK2 |
0.823 | 0.124 | -2 | 0.846 |
TSSK2 |
0.823 | 0.115 | -5 | 0.853 |
CAMK4 |
0.823 | 0.086 | -3 | 0.765 |
SGK3 |
0.823 | 0.167 | -3 | 0.747 |
MST4 |
0.822 | 0.004 | 2 | 0.770 |
PKG2 |
0.822 | 0.172 | -2 | 0.737 |
AURB |
0.822 | 0.171 | -2 | 0.738 |
NEK7 |
0.822 | -0.043 | -3 | 0.765 |
PAK6 |
0.821 | 0.146 | -2 | 0.766 |
MYLK4 |
0.821 | 0.166 | -2 | 0.822 |
NEK6 |
0.821 | -0.021 | -2 | 0.820 |
HUNK |
0.821 | -0.018 | 2 | 0.733 |
ATM |
0.821 | 0.086 | 1 | 0.785 |
CDKL5 |
0.820 | 0.054 | -3 | 0.769 |
FAM20C |
0.820 | 0.137 | 2 | 0.686 |
GRK1 |
0.820 | 0.071 | -2 | 0.710 |
AKT2 |
0.820 | 0.164 | -3 | 0.682 |
PKCA |
0.820 | 0.102 | 2 | 0.635 |
MNK1 |
0.819 | 0.131 | -2 | 0.842 |
CHK1 |
0.819 | 0.108 | -3 | 0.796 |
PKACA |
0.819 | 0.191 | -2 | 0.706 |
ERK5 |
0.819 | -0.029 | 1 | 0.689 |
DYRK4 |
0.818 | 0.161 | 1 | 0.612 |
BCKDK |
0.818 | -0.093 | -1 | 0.781 |
NUAK1 |
0.818 | 0.066 | -3 | 0.762 |
MASTL |
0.818 | -0.093 | -2 | 0.781 |
MELK |
0.817 | 0.068 | -3 | 0.774 |
AURA |
0.817 | 0.163 | -2 | 0.721 |
WNK3 |
0.817 | -0.131 | 1 | 0.796 |
SRPK3 |
0.817 | 0.101 | -3 | 0.693 |
SIK |
0.817 | 0.073 | -3 | 0.731 |
TGFBR1 |
0.817 | 0.088 | -2 | 0.771 |
GRK5 |
0.817 | -0.105 | -3 | 0.725 |
PKCB |
0.817 | 0.068 | 2 | 0.642 |
CDK8 |
0.817 | 0.034 | 1 | 0.676 |
PKCG |
0.816 | 0.058 | 2 | 0.655 |
PIM2 |
0.816 | 0.149 | -3 | 0.734 |
GRK6 |
0.816 | 0.002 | 1 | 0.801 |
QSK |
0.816 | 0.073 | 4 | 0.775 |
DLK |
0.816 | -0.020 | 1 | 0.826 |
CDK7 |
0.816 | 0.046 | 1 | 0.651 |
CHAK2 |
0.815 | -0.043 | -1 | 0.818 |
PLK1 |
0.815 | 0.036 | -2 | 0.788 |
PHKG1 |
0.815 | 0.040 | -3 | 0.770 |
HIPK2 |
0.814 | 0.134 | 1 | 0.599 |
PAK2 |
0.814 | 0.089 | -2 | 0.823 |
ALK4 |
0.814 | 0.048 | -2 | 0.795 |
DCAMKL1 |
0.814 | 0.113 | -3 | 0.744 |
RIPK1 |
0.813 | -0.078 | 1 | 0.795 |
MAPKAPK5 |
0.813 | 0.050 | -3 | 0.705 |
MLK1 |
0.813 | -0.119 | 2 | 0.716 |
ULK1 |
0.813 | -0.138 | -3 | 0.723 |
JNK2 |
0.813 | 0.110 | 1 | 0.620 |
NIM1 |
0.813 | -0.030 | 3 | 0.776 |
MARK3 |
0.812 | 0.067 | 4 | 0.741 |
MLK2 |
0.812 | -0.049 | 2 | 0.707 |
PLK3 |
0.812 | 0.043 | 2 | 0.742 |
KIS |
0.812 | 0.018 | 1 | 0.661 |
NEK9 |
0.812 | -0.089 | 2 | 0.721 |
CAMK1D |
0.812 | 0.158 | -3 | 0.674 |
BRSK1 |
0.812 | 0.045 | -3 | 0.751 |
HIPK1 |
0.812 | 0.134 | 1 | 0.694 |
PKCH |
0.811 | 0.047 | 2 | 0.622 |
CDK19 |
0.811 | 0.034 | 1 | 0.641 |
DYRK1A |
0.810 | 0.118 | 1 | 0.711 |
MARK2 |
0.810 | 0.049 | 4 | 0.722 |
CAMK1G |
0.810 | 0.093 | -3 | 0.731 |
GRK4 |
0.810 | -0.103 | -2 | 0.758 |
AKT1 |
0.810 | 0.164 | -3 | 0.704 |
BMPR1B |
0.810 | 0.092 | 1 | 0.717 |
CDK13 |
0.809 | 0.040 | 1 | 0.629 |
DRAK1 |
0.809 | 0.092 | 1 | 0.790 |
ANKRD3 |
0.809 | -0.107 | 1 | 0.843 |
BRSK2 |
0.809 | 0.005 | -3 | 0.768 |
JNK3 |
0.809 | 0.083 | 1 | 0.641 |
P70S6K |
0.809 | 0.100 | -3 | 0.711 |
PASK |
0.808 | 0.187 | -3 | 0.790 |
QIK |
0.808 | -0.033 | -3 | 0.783 |
PKCZ |
0.807 | 0.013 | 2 | 0.667 |
DYRK3 |
0.807 | 0.152 | 1 | 0.703 |
TLK2 |
0.807 | -0.016 | 1 | 0.804 |
NEK2 |
0.807 | -0.020 | 2 | 0.698 |
CDK18 |
0.807 | 0.066 | 1 | 0.588 |
SMMLCK |
0.806 | 0.138 | -3 | 0.777 |
SMG1 |
0.806 | 0.028 | 1 | 0.786 |
GRK7 |
0.806 | 0.045 | 1 | 0.726 |
VRK2 |
0.806 | -0.025 | 1 | 0.830 |
MARK1 |
0.806 | 0.032 | 4 | 0.757 |
DCAMKL2 |
0.805 | 0.064 | -3 | 0.769 |
TTBK2 |
0.805 | -0.161 | 2 | 0.616 |
MEK1 |
0.805 | -0.082 | 2 | 0.751 |
IRE2 |
0.805 | -0.044 | 2 | 0.619 |
CDK5 |
0.805 | 0.061 | 1 | 0.662 |
CDK12 |
0.804 | 0.044 | 1 | 0.614 |
ALK2 |
0.804 | 0.045 | -2 | 0.768 |
CDK9 |
0.804 | 0.029 | 1 | 0.638 |
YSK4 |
0.804 | -0.065 | 1 | 0.767 |
PKR |
0.804 | -0.059 | 1 | 0.783 |
DYRK1B |
0.803 | 0.099 | 1 | 0.640 |
PKCT |
0.803 | 0.066 | 2 | 0.619 |
PAK5 |
0.803 | 0.111 | -2 | 0.720 |
CDK1 |
0.803 | 0.053 | 1 | 0.623 |
MLK3 |
0.803 | -0.065 | 2 | 0.659 |
HIPK3 |
0.803 | 0.095 | 1 | 0.695 |
PAK4 |
0.803 | 0.123 | -2 | 0.733 |
P38B |
0.803 | 0.073 | 1 | 0.592 |
SGK1 |
0.802 | 0.162 | -3 | 0.629 |
ACVR2B |
0.802 | 0.016 | -2 | 0.755 |
ACVR2A |
0.802 | 0.006 | -2 | 0.747 |
AKT3 |
0.800 | 0.160 | -3 | 0.635 |
P38A |
0.800 | 0.036 | 1 | 0.654 |
IRE1 |
0.800 | -0.139 | 1 | 0.730 |
MLK4 |
0.800 | -0.077 | 2 | 0.620 |
PLK4 |
0.800 | -0.075 | 2 | 0.523 |
CAMK1A |
0.799 | 0.150 | -3 | 0.655 |
P38G |
0.799 | 0.052 | 1 | 0.547 |
DAPK3 |
0.798 | 0.159 | -3 | 0.756 |
CDK17 |
0.798 | 0.042 | 1 | 0.551 |
SNRK |
0.797 | -0.098 | 2 | 0.560 |
CHAK1 |
0.797 | -0.114 | 2 | 0.670 |
CHK2 |
0.797 | 0.119 | -3 | 0.640 |
MRCKA |
0.797 | 0.152 | -3 | 0.739 |
SBK |
0.796 | 0.145 | -3 | 0.596 |
SSTK |
0.796 | 0.046 | 4 | 0.757 |
PKN1 |
0.796 | 0.088 | -3 | 0.717 |
PHKG2 |
0.796 | 0.003 | -3 | 0.754 |
WNK4 |
0.796 | -0.078 | -2 | 0.852 |
CDK10 |
0.796 | 0.079 | 1 | 0.627 |
CDK14 |
0.796 | 0.061 | 1 | 0.642 |
PKCE |
0.795 | 0.079 | 2 | 0.642 |
ERK1 |
0.795 | 0.026 | 1 | 0.593 |
CDK3 |
0.794 | 0.066 | 1 | 0.559 |
BRAF |
0.794 | -0.037 | -4 | 0.830 |
BMPR1A |
0.794 | 0.050 | 1 | 0.702 |
ROCK2 |
0.794 | 0.163 | -3 | 0.759 |
MAK |
0.794 | 0.153 | -2 | 0.735 |
P38D |
0.794 | 0.077 | 1 | 0.557 |
MRCKB |
0.793 | 0.139 | -3 | 0.724 |
CDK2 |
0.793 | -0.020 | 1 | 0.708 |
PKCI |
0.793 | 0.023 | 2 | 0.637 |
MST3 |
0.793 | -0.012 | 2 | 0.755 |
GSK3B |
0.793 | 0.030 | 4 | 0.476 |
MEKK1 |
0.792 | -0.111 | 1 | 0.815 |
NEK5 |
0.792 | -0.029 | 1 | 0.795 |
GSK3A |
0.792 | 0.055 | 4 | 0.484 |
GRK2 |
0.792 | -0.051 | -2 | 0.650 |
ZAK |
0.791 | -0.102 | 1 | 0.807 |
PRP4 |
0.791 | -0.003 | -3 | 0.653 |
ERK2 |
0.791 | -0.010 | 1 | 0.641 |
DAPK1 |
0.791 | 0.140 | -3 | 0.738 |
MPSK1 |
0.791 | 0.027 | 1 | 0.694 |
PERK |
0.790 | -0.163 | -2 | 0.771 |
IRAK4 |
0.789 | -0.090 | 1 | 0.756 |
CDK16 |
0.789 | 0.046 | 1 | 0.561 |
HRI |
0.789 | -0.197 | -2 | 0.805 |
PINK1 |
0.788 | -0.126 | 1 | 0.758 |
TAO3 |
0.788 | -0.065 | 1 | 0.783 |
MEK5 |
0.788 | -0.232 | 2 | 0.720 |
PDK1 |
0.787 | 0.011 | 1 | 0.797 |
TLK1 |
0.787 | -0.145 | -2 | 0.786 |
DMPK1 |
0.786 | 0.183 | -3 | 0.732 |
PLK2 |
0.786 | 0.019 | -3 | 0.641 |
LKB1 |
0.786 | 0.006 | -3 | 0.742 |
PKG1 |
0.786 | 0.116 | -2 | 0.670 |
GCK |
0.786 | 0.028 | 1 | 0.805 |
JNK1 |
0.785 | 0.047 | 1 | 0.603 |
TTBK1 |
0.784 | -0.136 | 2 | 0.553 |
MOK |
0.784 | 0.105 | 1 | 0.663 |
CRIK |
0.784 | 0.139 | -3 | 0.710 |
GAK |
0.783 | -0.004 | 1 | 0.747 |
MEKK3 |
0.783 | -0.216 | 1 | 0.799 |
NEK4 |
0.783 | -0.035 | 1 | 0.781 |
BUB1 |
0.782 | 0.098 | -5 | 0.824 |
MEKK2 |
0.781 | -0.189 | 2 | 0.686 |
HPK1 |
0.781 | 0.014 | 1 | 0.797 |
CAMKK1 |
0.781 | -0.115 | -2 | 0.707 |
NEK1 |
0.781 | 0.027 | 1 | 0.772 |
KHS1 |
0.781 | 0.062 | 1 | 0.786 |
MAP3K15 |
0.781 | -0.042 | 1 | 0.782 |
NEK8 |
0.780 | -0.117 | 2 | 0.708 |
NEK11 |
0.780 | -0.144 | 1 | 0.812 |
TNIK |
0.780 | 0.003 | 3 | 0.843 |
MEKK6 |
0.780 | -0.066 | 1 | 0.766 |
ERK7 |
0.780 | -0.010 | 2 | 0.461 |
IRAK1 |
0.780 | -0.197 | -1 | 0.763 |
TAO2 |
0.780 | -0.113 | 2 | 0.749 |
HGK |
0.780 | -0.032 | 3 | 0.847 |
ROCK1 |
0.779 | 0.131 | -3 | 0.733 |
CDK4 |
0.779 | 0.032 | 1 | 0.604 |
CAMKK2 |
0.779 | -0.102 | -2 | 0.703 |
MST2 |
0.778 | -0.063 | 1 | 0.799 |
TAK1 |
0.778 | -0.036 | 1 | 0.815 |
LOK |
0.777 | -0.042 | -2 | 0.749 |
KHS2 |
0.777 | 0.045 | 1 | 0.804 |
MINK |
0.777 | -0.055 | 1 | 0.794 |
GRK3 |
0.776 | -0.066 | -2 | 0.604 |
CDK6 |
0.776 | 0.022 | 1 | 0.618 |
VRK1 |
0.776 | -0.052 | 2 | 0.707 |
STK33 |
0.774 | -0.100 | 2 | 0.564 |
CK2A2 |
0.774 | 0.018 | 1 | 0.592 |
LRRK2 |
0.773 | -0.138 | 2 | 0.746 |
MST1 |
0.772 | -0.063 | 1 | 0.789 |
CK1G1 |
0.772 | -0.142 | -3 | 0.354 |
EEF2K |
0.771 | -0.076 | 3 | 0.809 |
SLK |
0.771 | -0.079 | -2 | 0.676 |
RIPK2 |
0.771 | -0.148 | 1 | 0.766 |
CK1E |
0.769 | -0.155 | -3 | 0.354 |
MEK2 |
0.768 | -0.156 | 2 | 0.689 |
PDHK3_TYR |
0.767 | 0.243 | 4 | 0.855 |
YSK1 |
0.767 | -0.089 | 2 | 0.697 |
CK2A1 |
0.765 | 0.013 | 1 | 0.580 |
CK1D |
0.765 | -0.137 | -3 | 0.306 |
PBK |
0.764 | -0.059 | 1 | 0.650 |
CK1A2 |
0.763 | -0.137 | -3 | 0.306 |
NEK3 |
0.761 | -0.126 | 1 | 0.761 |
ASK1 |
0.760 | -0.057 | 1 | 0.769 |
PDHK4_TYR |
0.757 | 0.116 | 2 | 0.820 |
TTK |
0.757 | -0.061 | -2 | 0.798 |
OSR1 |
0.756 | -0.099 | 2 | 0.685 |
BIKE |
0.756 | -0.019 | 1 | 0.619 |
LIMK2_TYR |
0.755 | 0.074 | -3 | 0.818 |
HASPIN |
0.755 | -0.046 | -1 | 0.686 |
TESK1_TYR |
0.755 | 0.007 | 3 | 0.869 |
YANK3 |
0.754 | -0.062 | 2 | 0.403 |
MYO3B |
0.754 | -0.065 | 2 | 0.717 |
PKMYT1_TYR |
0.753 | -0.032 | 3 | 0.835 |
MAP2K4_TYR |
0.752 | -0.027 | -1 | 0.845 |
MAP2K7_TYR |
0.752 | -0.083 | 2 | 0.779 |
MAP2K6_TYR |
0.752 | 0.006 | -1 | 0.843 |
RET |
0.751 | 0.025 | 1 | 0.790 |
TAO1 |
0.749 | -0.127 | 1 | 0.738 |
BMPR2_TYR |
0.749 | -0.020 | -1 | 0.796 |
MYO3A |
0.748 | -0.113 | 1 | 0.777 |
PDHK1_TYR |
0.747 | -0.056 | -1 | 0.848 |
DDR1 |
0.746 | -0.018 | 4 | 0.766 |
PINK1_TYR |
0.745 | -0.147 | 1 | 0.777 |
AAK1 |
0.745 | 0.034 | 1 | 0.510 |
ALPHAK3 |
0.744 | -0.116 | -1 | 0.725 |
JAK2 |
0.744 | -0.017 | 1 | 0.793 |
MST1R |
0.743 | -0.066 | 3 | 0.793 |
TYK2 |
0.743 | -0.066 | 1 | 0.786 |
EPHB4 |
0.743 | 0.006 | -1 | 0.780 |
ROS1 |
0.742 | -0.021 | 3 | 0.776 |
TYRO3 |
0.742 | -0.050 | 3 | 0.797 |
EPHA6 |
0.741 | -0.022 | -1 | 0.779 |
STLK3 |
0.741 | -0.146 | 1 | 0.770 |
CSF1R |
0.741 | -0.023 | 3 | 0.775 |
DDR2 |
0.741 | 0.115 | 3 | 0.736 |
ITK |
0.741 | 0.050 | -1 | 0.781 |
TNK2 |
0.741 | 0.006 | 3 | 0.755 |
LIMK1_TYR |
0.739 | -0.172 | 2 | 0.748 |
TXK |
0.739 | 0.074 | 1 | 0.753 |
YES1 |
0.739 | -0.003 | -1 | 0.855 |
SRMS |
0.738 | 0.021 | 1 | 0.774 |
JAK1 |
0.738 | 0.044 | 1 | 0.767 |
NEK10_TYR |
0.737 | -0.030 | 1 | 0.673 |
TNNI3K_TYR |
0.737 | 0.029 | 1 | 0.790 |
AXL |
0.737 | -0.015 | 3 | 0.777 |
JAK3 |
0.736 | -0.073 | 1 | 0.774 |
EPHB1 |
0.736 | -0.005 | 1 | 0.782 |
EPHA4 |
0.736 | -0.015 | 2 | 0.764 |
TNK1 |
0.736 | -0.022 | 3 | 0.770 |
FGR |
0.735 | -0.053 | 1 | 0.761 |
ABL2 |
0.735 | -0.039 | -1 | 0.789 |
FGFR2 |
0.734 | -0.084 | 3 | 0.788 |
PDGFRB |
0.734 | -0.087 | 3 | 0.785 |
TEK |
0.734 | -0.053 | 3 | 0.743 |
FER |
0.733 | -0.092 | 1 | 0.775 |
INSRR |
0.733 | -0.068 | 3 | 0.753 |
BMX |
0.733 | 0.028 | -1 | 0.703 |
EPHB2 |
0.733 | -0.007 | -1 | 0.760 |
CK1A |
0.733 | -0.135 | -3 | 0.216 |
EPHB3 |
0.732 | -0.028 | -1 | 0.764 |
FGFR1 |
0.732 | -0.091 | 3 | 0.766 |
MERTK |
0.732 | -0.018 | 3 | 0.769 |
KIT |
0.732 | -0.071 | 3 | 0.774 |
FLT3 |
0.729 | -0.111 | 3 | 0.784 |
ABL1 |
0.729 | -0.079 | -1 | 0.792 |
LCK |
0.728 | -0.040 | -1 | 0.803 |
KDR |
0.728 | -0.097 | 3 | 0.733 |
HCK |
0.728 | -0.090 | -1 | 0.803 |
TEC |
0.726 | -0.043 | -1 | 0.736 |
EPHA7 |
0.725 | -0.034 | 2 | 0.744 |
PTK2B |
0.725 | 0.005 | -1 | 0.795 |
NTRK1 |
0.724 | -0.115 | -1 | 0.794 |
PDGFRA |
0.724 | -0.167 | 3 | 0.779 |
BTK |
0.724 | -0.122 | -1 | 0.770 |
MET |
0.724 | -0.105 | 3 | 0.771 |
BLK |
0.724 | -0.037 | -1 | 0.796 |
EPHA1 |
0.723 | -0.066 | 3 | 0.750 |
FYN |
0.722 | -0.011 | -1 | 0.784 |
ALK |
0.722 | -0.107 | 3 | 0.710 |
FGFR3 |
0.722 | -0.105 | 3 | 0.758 |
EPHA3 |
0.722 | -0.088 | 2 | 0.718 |
PTK6 |
0.722 | -0.156 | -1 | 0.747 |
WEE1_TYR |
0.720 | -0.113 | -1 | 0.757 |
LTK |
0.719 | -0.120 | 3 | 0.721 |
NTRK2 |
0.718 | -0.156 | 3 | 0.744 |
EPHA5 |
0.718 | -0.040 | 2 | 0.741 |
NTRK3 |
0.718 | -0.095 | -1 | 0.753 |
INSR |
0.718 | -0.127 | 3 | 0.736 |
FLT4 |
0.717 | -0.158 | 3 | 0.733 |
ERBB2 |
0.717 | -0.154 | 1 | 0.759 |
FLT1 |
0.717 | -0.143 | -1 | 0.745 |
FRK |
0.716 | -0.104 | -1 | 0.793 |
CSK |
0.716 | -0.100 | 2 | 0.736 |
YANK2 |
0.715 | -0.117 | 2 | 0.420 |
EPHA8 |
0.713 | -0.077 | -1 | 0.730 |
EGFR |
0.713 | -0.074 | 1 | 0.685 |
LYN |
0.713 | -0.106 | 3 | 0.700 |
MATK |
0.712 | -0.119 | -1 | 0.725 |
SRC |
0.712 | -0.076 | -1 | 0.798 |
FGFR4 |
0.712 | -0.083 | -1 | 0.731 |
CK1G3 |
0.706 | -0.169 | -3 | 0.174 |
EPHA2 |
0.705 | -0.072 | -1 | 0.683 |
PTK2 |
0.705 | -0.037 | -1 | 0.666 |
IGF1R |
0.702 | -0.128 | 3 | 0.679 |
MUSK |
0.700 | -0.154 | 1 | 0.649 |
SYK |
0.698 | -0.086 | -1 | 0.674 |
ERBB4 |
0.698 | -0.087 | 1 | 0.693 |
FES |
0.688 | -0.136 | -1 | 0.700 |
CK1G2 |
0.686 | -0.168 | -3 | 0.267 |
ZAP70 |
0.679 | -0.092 | -1 | 0.626 |