Motif 129 (n=173)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NJZ7 | RIMBP3C | S1294 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NKT7 | RGPD3 | S392 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NNM3 | RIMBP3B | S1294 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A7XYQ1 | SOBP | S594 | ochoa | Sine oculis-binding protein homolog (Jackson circler protein 1) | Implicated in development of the cochlea. {ECO:0000250|UniProtKB:Q0P5V2}. |
| O00559 | EBAG9 | S62 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14578 | CIT | S1432 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14649 | KCNK3 | S372 | ochoa | Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:23169818, PubMed:26919430, PubMed:32499642, PubMed:36195757, PubMed:9312005). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (PubMed:22948150). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:23169818, PubMed:32499642). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:O35111, ECO:0000250|UniProtKB:O54912, ECO:0000269|PubMed:22948150, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:32499642, ECO:0000269|PubMed:36195757, ECO:0000269|PubMed:9312005}. |
| O14994 | SYN3 | S539 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
| O15117 | FYB1 | S245 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15119 | TBX3 | S435 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15389 | SIGLEC5 | S488 | ochoa | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| O43166 | SIPA1L1 | S94 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43663 | PRC1 | S513 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43683 | BUB1 | S511 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60238 | BNIP3L | S34 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60563 | CCNT1 | S629 | psp | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60883 | GPR37L1 | S462 | ochoa | G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}. |
| O60885 | BRD4 | S338 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75052 | NOS1AP | S266 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75410 | TACC1 | S576 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75899 | GABBR2 | S776 | ochoa | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}. |
| O94885 | SASH1 | S329 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94887 | FARP2 | S1033 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95155 | UBE4B | S358 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95429 | BAG4 | S176 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95684 | CEP43 | S205 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95714 | HERC2 | S1365 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95865 | DDAH2 | S253 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| P04629 | NTRK1 | S677 | ochoa | High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}. |
| P0C671 | BNIP5 | S463 | ochoa | Protein BNIP5 | None |
| P10070 | GLI2 | S255 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P16070 | CD44 | S180 | ochoa | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P20585 | MSH3 | S30 | ochoa | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| P21333 | FLNA | S1923 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25054 | APC | S960 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27816 | MAP4 | S71 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28749 | RBL1 | S776 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P29350 | PTPN6 | S138 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P43268 | ETV4 | S73 | psp | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
| P43364 | MAGEA11 | S208 | ochoa|psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P48634 | PRRC2A | S2074 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49792 | RANBP2 | S391 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51116 | FXR2 | S637 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51587 | BRCA2 | Y2363 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52630 | STAT2 | S595 | ochoa | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P54868 | HMGCS2 | S433 | ochoa | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}. |
| P56945 | BCAR1 | S292 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P60709 | ACTB | Y166 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | Y168 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | Y166 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | Y167 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | Y168 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | Y168 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78527 | PRKDC | S2117 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P85037 | FOXK1 | S377 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P98171 | ARHGAP4 | S408 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q01167 | FOXK2 | S330 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01543 | FLI1 | S76 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q01543 | FLI1 | S79 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q03111 | MLLT1 | S411 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q04656 | ATP7A | S1476 | psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q05516 | ZBTB16 | S253 | ochoa | Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) | Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). {ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:24359566}. |
| Q08AE8 | SPIRE1 | S433 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q12948 | FOXC1 | S528 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q12955 | ANK3 | S2417 | psp | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q12959 | DLG1 | S443 | ochoa|psp | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13021 | MALL | S66 | ochoa | MAL-like protein (Protein BENE) | None |
| Q13433 | SLC39A6 | S220 | ochoa | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}. |
| Q13950 | RUNX2 | S347 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14498 | RBM39 | S117 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14694 | USP10 | S27 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q15434 | RBMS2 | S35 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q15583 | TGIF1 | S149 | ochoa | Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Q155Q3 | DIXDC1 | S590 | ochoa | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}. |
| Q16706 | MAN2A1 | S80 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q16760 | DGKD | S666 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q4ADV7 | RIC1 | S995 | ochoa | Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}. |
| Q5M775 | SPECC1 | S35 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SWA1 | PPP1R15B | S614 | ochoa | Protein phosphatase 1 regulatory subunit 15B | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269|PubMed:26159176, ECO:0000269|PubMed:26307080}. |
| Q5SYE7 | NHSL1 | S544 | ochoa | NHS-like protein 1 | None |
| Q5VVJ2 | MYSM1 | S265 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q6GYQ0 | RALGAPA1 | S371 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6P0Q8 | MAST2 | S108 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PJI9 | WDR59 | S564 | ochoa | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}. |
| Q6R327 | RICTOR | S1101 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6V0I7 | FAT4 | S4699 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6WKZ4 | RAB11FIP1 | S1154 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZSR9 | None | Y28 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q70CQ4 | USP31 | S884 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q76FK4 | NOL8 | S673 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q76I76 | SSH2 | S1215 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q76N32 | CEP68 | S332 | psp | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7LBC6 | KDM3B | S563 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7LBC6 | KDM3B | S1320 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z353 | HDX | S395 | ochoa | Highly divergent homeobox | None |
| Q7Z3B3 | KANSL1 | S246 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z3J3 | RGPD4 | S392 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3T8 | ZFYVE16 | S167 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z569 | BRAP | S117 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q7Z6J2 | TAMALIN | S235 | ochoa | Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) | Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}. |
| Q7Z6M1 | RABEPK | S27 | ochoa | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}. |
| Q86SQ0 | PHLDB2 | S173 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86SQ0 | PHLDB2 | S309 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86YP4 | GATAD2A | S598 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IWB9 | TEX2 | S141 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IWR0 | ZC3H7A | S314 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8IYA6 | CKAP2L | S110 | ochoa | Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis) | Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. {ECO:0000269|PubMed:25439729}. |
| Q8NDX5 | PHC3 | S228 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEY1 | NAV1 | S806 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHQ8 | RASSF8 | S385 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8TBP0 | TBC1D16 | S257 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TCG1 | CIP2A | S572 | ochoa | Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) | Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}. |
| Q8TCU6 | PREX1 | S313 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDM6 | DLG5 | S1076 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8WUY3 | PRUNE2 | S844 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92545 | TMEM131 | S1495 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92608 | DOCK2 | S1736 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92628 | KIAA0232 | S707 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q969G9 | NKD1 | S169 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q96BY7 | ATG2B | S493 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96CB8 | INTS12 | S389 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96EN8 | MOCOS | S682 | ochoa | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) | Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608). {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608, ECO:0000269|PubMed:34356852}. |
| Q96MK2 | RIPOR3 | S397 | ochoa | RIPOR family member 3 | None |
| Q96RV3 | PCNX1 | S323 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96SN8 | CDK5RAP2 | S1672 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99570 | PIK3R4 | S895 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99698 | LYST | S2103 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99704 | DOK1 | S313 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BQ15 | NABP2 | S134 | psp | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}. |
| Q9BUJ2 | HNRNPUL1 | S748 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BVR0 | HERC2P3 | S92 | ochoa | Putative HERC2-like protein 3 | None |
| Q9BX66 | SORBS1 | S495 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BX66 | SORBS1 | S534 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZL4 | PPP1R12C | S336 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9H2P0 | ADNP | S970 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H9Q4 | NHEJ1 | S132 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HB90 | RRAGC | S95 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9HBL0 | TNS1 | S1393 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9HC44 | GPBP1L1 | S299 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NP62 | GCM1 | S275 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NSC2 | SALL1 | S1106 | ochoa | Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}. |
| Q9NSI6 | BRWD1 | S2048 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NTM9 | CUTC | S239 | ochoa | Copper homeostasis protein cutC homolog | May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. {ECO:0000269|PubMed:16182249, ECO:0000269|PubMed:19878721}. |
| Q9UBH6 | XPR1 | S666 | ochoa | Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1) | Inorganic ion transporter that mediates phosphate ion export across plasma membrane (PubMed:23791524, PubMed:25938945, PubMed:27080106, PubMed:31043717, PubMed:39169184, PubMed:39325866, PubMed:39747008, PubMed:39814721). Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling (PubMed:27080106). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), which are important intracellular signaling molecules involved in regulation of phosphate flux (PubMed:27080106, PubMed:39169184, PubMed:39325866). {ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945, ECO:0000269|PubMed:27080106, ECO:0000269|PubMed:31043717, ECO:0000269|PubMed:39169184, ECO:0000269|PubMed:39325866, ECO:0000269|PubMed:39747008, ECO:0000269|PubMed:39814721}. |
| Q9UFD9 | RIMBP3 | S1294 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UHN1 | POLG2 | S38 | ochoa | DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. {ECO:0000269|PubMed:11477093, ECO:0000269|PubMed:11477094, ECO:0000269|PubMed:11504725, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:19837034, ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:30157269, ECO:0000269|PubMed:31778857, ECO:0000269|PubMed:37202477}. |
| Q9ULD2 | MTUS1 | S399 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULH1 | ASAP1 | S305 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULS5 | TMCC3 | S174 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9ULT8 | HECTD1 | S1485 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMZ2 | SYNRG | S475 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPN4 | CEP131 | S224 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y2E4 | DIP2C | S218 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2H9 | MAST1 | S41 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2K9 | STXBP5L | S766 | psp | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}. |
| Q9Y2L6 | FRMD4B | S675 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y490 | TLN1 | S1323 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y520 | PRRC2C | S2186 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5F8 | PCDHGB7 | S498 | ochoa | Protocadherin gamma-B7 (PCDH-gamma-B7) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Q9Y6N7 | ROBO1 | S1152 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| O00444 | PLK4 | S441 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P55036 | PSMD4 | S39 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| Q7Z3K3 | POGZ | S35 | Sugiyama | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q96ST3 | SIN3A | S158 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| P28329 | CHAT | S465 | SIGNOR|EPSD | Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) | Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269|PubMed:17144655}. |
| O94919 | ENDOD1 | S137 | Sugiyama | Endonuclease domain-containing 1 protein (EC 3.1.30.-) | May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000269|PubMed:32614325}. |
| P07949 | RET | S1065 | Sugiyama | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P09619 | PDGFRB | S980 | Sugiyama | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}. |
| P36888 | FLT3 | S838 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| Q8TDN4 | CABLES1 | S273 | SIGNOR | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q01973 | ROR1 | S642 | Sugiyama | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350, ECO:0000269|PubMed:36949068}. |
| Q9P2K8 | EIF2AK4 | S1049 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| O00443 | PIK3C2A | S619 | Sugiyama | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 2.179415e-08 | 7.662 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 9.016953e-06 | 5.045 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 1.057316e-04 | 3.976 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.981385e-04 | 3.703 |
| R-HSA-9830674 | Formation of the ureteric bud | 5.432259e-04 | 3.265 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.130084e-04 | 3.147 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.086949e-03 | 2.964 |
| R-HSA-187042 | TRKA activation by NGF | 1.896353e-03 | 2.722 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.215259e-03 | 2.655 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.215259e-03 | 2.655 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.892311e-03 | 2.723 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 2.708242e-03 | 2.567 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.643614e-03 | 2.578 |
| R-HSA-9830369 | Kidney development | 2.798877e-03 | 2.553 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.872213e-03 | 2.412 |
| R-HSA-447038 | NrCAM interactions | 3.655869e-03 | 2.437 |
| R-HSA-380287 | Centrosome maturation | 4.287663e-03 | 2.368 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.120629e-03 | 2.291 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.120629e-03 | 2.291 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.120629e-03 | 2.291 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.120629e-03 | 2.291 |
| R-HSA-162582 | Signal Transduction | 4.648251e-03 | 2.333 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 1.252761e-02 | 1.902 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.252761e-02 | 1.902 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 1.252761e-02 | 1.902 |
| R-HSA-187015 | Activation of TRKA receptors | 7.278553e-03 | 2.138 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.278553e-03 | 2.138 |
| R-HSA-196025 | Formation of annular gap junctions | 8.734832e-03 | 2.059 |
| R-HSA-190873 | Gap junction degradation | 1.031002e-02 | 1.987 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.200094e-02 | 1.921 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 8.719801e-03 | 2.059 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.126675e-03 | 2.090 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.822057e-03 | 2.054 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.556444e-03 | 2.183 |
| R-HSA-68877 | Mitotic Prometaphase | 5.870231e-03 | 2.231 |
| R-HSA-445355 | Smooth Muscle Contraction | 7.792647e-03 | 2.108 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 8.734832e-03 | 2.059 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.156577e-02 | 1.937 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.156577e-02 | 1.937 |
| R-HSA-1500931 | Cell-Cell communication | 1.087795e-02 | 1.963 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 1.380447e-02 | 1.860 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.380447e-02 | 1.860 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.761311e-02 | 1.754 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.870034e-02 | 1.728 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.920548e-02 | 1.717 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.870034e-02 | 1.728 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.922730e-02 | 1.716 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.735890e-02 | 1.760 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.972773e-02 | 1.705 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.891213e-02 | 1.723 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.014285e-02 | 1.696 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.208443e-02 | 1.656 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.208443e-02 | 1.656 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 2.489903e-02 | 1.604 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.489903e-02 | 1.604 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.489903e-02 | 1.604 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.468432e-02 | 1.608 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.468432e-02 | 1.608 |
| R-HSA-373760 | L1CAM interactions | 2.532828e-02 | 1.596 |
| R-HSA-169893 | Prolonged ERK activation events | 2.682330e-02 | 1.571 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.682330e-02 | 1.571 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.193182e-02 | 1.496 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.203187e-02 | 1.494 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.203187e-02 | 1.494 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.098365e-02 | 1.509 |
| R-HSA-397014 | Muscle contraction | 2.881737e-02 | 1.540 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.193182e-02 | 1.496 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 2.933270e-02 | 1.533 |
| R-HSA-418990 | Adherens junctions interactions | 3.240325e-02 | 1.489 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.459272e-02 | 1.461 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.461804e-02 | 1.461 |
| R-HSA-446728 | Cell junction organization | 3.647329e-02 | 1.438 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 3.711622e-02 | 1.430 |
| R-HSA-1299316 | TWIK-releated acid-sensitive K+ channel (TASK) | 3.711622e-02 | 1.430 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.711622e-02 | 1.430 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 4.618345e-02 | 1.336 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.618345e-02 | 1.336 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.024161e-02 | 1.395 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.618345e-02 | 1.336 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 4.317396e-02 | 1.365 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.806074e-02 | 1.318 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 4.918109e-02 | 1.308 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.926770e-02 | 1.307 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 4.926770e-02 | 1.307 |
| R-HSA-5617833 | Cilium Assembly | 5.046039e-02 | 1.297 |
| R-HSA-167021 | PLC-gamma1 signalling | 6.109551e-02 | 1.214 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 6.109551e-02 | 1.214 |
| R-HSA-198745 | Signalling to STAT3 | 6.109551e-02 | 1.214 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.759750e-02 | 1.240 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.302253e-02 | 1.276 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 6.109551e-02 | 1.214 |
| R-HSA-9620244 | Long-term potentiation | 5.894603e-02 | 1.230 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 6.109551e-02 | 1.214 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.562327e-02 | 1.255 |
| R-HSA-422475 | Axon guidance | 5.634718e-02 | 1.249 |
| R-HSA-1266695 | Interleukin-7 signaling | 5.894603e-02 | 1.230 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 5.894603e-02 | 1.230 |
| R-HSA-9830364 | Formation of the nephric duct | 5.894603e-02 | 1.230 |
| R-HSA-421270 | Cell-cell junction organization | 5.744130e-02 | 1.241 |
| R-HSA-5688426 | Deubiquitination | 6.111366e-02 | 1.214 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 6.230655e-02 | 1.205 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.371620e-02 | 1.196 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 6.573066e-02 | 1.182 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.582008e-02 | 1.182 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.654638e-02 | 1.177 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 7.286137e-02 | 1.138 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 8.448050e-02 | 1.073 |
| R-HSA-186763 | Downstream signal transduction | 8.002160e-02 | 1.097 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 6.921626e-02 | 1.160 |
| R-HSA-1538133 | G0 and Early G1 | 8.373297e-02 | 1.077 |
| R-HSA-9729555 | Sensory perception of sour taste | 7.286137e-02 | 1.138 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 6.921626e-02 | 1.160 |
| R-HSA-9927353 | Co-inhibition by BTLA | 8.448050e-02 | 1.073 |
| R-HSA-9675108 | Nervous system development | 8.135862e-02 | 1.090 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.815000e-02 | 1.167 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.792394e-02 | 1.168 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.168802e-02 | 1.088 |
| R-HSA-9008059 | Interleukin-37 signaling | 7.636373e-02 | 1.117 |
| R-HSA-187024 | NGF-independant TRKA activation | 9.595472e-02 | 1.018 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 9.595472e-02 | 1.018 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 9.595472e-02 | 1.018 |
| R-HSA-9645135 | STAT5 Activation | 1.072858e-01 | 0.969 |
| R-HSA-170984 | ARMS-mediated activation | 1.404382e-01 | 0.853 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.404382e-01 | 0.853 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.512144e-01 | 0.820 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.512144e-01 | 0.820 |
| R-HSA-4839744 | Signaling by APC mutants | 1.618562e-01 | 0.791 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.618562e-01 | 0.791 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.618562e-01 | 0.791 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.618562e-01 | 0.791 |
| R-HSA-428540 | Activation of RAC1 | 1.723652e-01 | 0.764 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.723652e-01 | 0.764 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.827431e-01 | 0.738 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.827431e-01 | 0.738 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.827431e-01 | 0.738 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.827431e-01 | 0.738 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.827431e-01 | 0.738 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.031120e-01 | 0.692 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.131062e-01 | 0.671 |
| R-HSA-390522 | Striated Muscle Contraction | 9.130863e-02 | 1.039 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.229757e-01 | 0.652 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.229757e-01 | 0.652 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.229757e-01 | 0.652 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.327220e-01 | 0.633 |
| R-HSA-8853659 | RET signaling | 1.030271e-01 | 0.987 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.612369e-01 | 0.583 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.705056e-01 | 0.568 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.705056e-01 | 0.568 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.705056e-01 | 0.568 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.705056e-01 | 0.568 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.705056e-01 | 0.568 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.796585e-01 | 0.553 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.064373e-01 | 0.514 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.754593e-01 | 0.756 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3.237371e-01 | 0.490 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 3.237371e-01 | 0.490 |
| R-HSA-1296059 | G protein gated Potassium channels | 3.237371e-01 | 0.490 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.237371e-01 | 0.490 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.406075e-01 | 0.468 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.406075e-01 | 0.468 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.118006e-01 | 0.674 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.891903e-02 | 1.051 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.799489e-01 | 0.745 |
| R-HSA-354192 | Integrin signaling | 8.749593e-02 | 1.058 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.194779e-01 | 0.923 |
| R-HSA-198203 | PI3K/AKT activation | 1.512144e-01 | 0.820 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.705056e-01 | 0.568 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.423466e-01 | 0.616 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 9.595472e-02 | 1.018 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.446200e-01 | 0.840 |
| R-HSA-186797 | Signaling by PDGF | 2.210062e-01 | 0.656 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.327220e-01 | 0.633 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.317884e-01 | 0.880 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.799489e-01 | 0.745 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.151416e-01 | 0.501 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.275725e-01 | 0.894 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.612369e-01 | 0.583 |
| R-HSA-187687 | Signalling to ERKs | 9.907599e-02 | 1.004 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.512144e-01 | 0.820 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.723652e-01 | 0.764 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.723652e-01 | 0.764 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.929915e-01 | 0.714 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.229757e-01 | 0.652 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.518511e-01 | 0.599 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.518511e-01 | 0.599 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.754593e-01 | 0.756 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.627289e-01 | 0.580 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.627289e-01 | 0.580 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.711292e-01 | 0.767 |
| R-HSA-5358508 | Mismatch Repair | 2.518511e-01 | 0.599 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.766748e-01 | 0.558 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.404382e-01 | 0.853 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.512144e-01 | 0.820 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.533139e-01 | 0.814 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.976230e-01 | 0.526 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.313789e-01 | 0.480 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.487879e-01 | 0.604 |
| R-HSA-170968 | Frs2-mediated activation | 1.929915e-01 | 0.714 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.131062e-01 | 0.671 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 8.749593e-02 | 1.058 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.264680e-02 | 1.033 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.275725e-01 | 0.894 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.140698e-01 | 0.943 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.275725e-01 | 0.894 |
| R-HSA-167044 | Signalling to RAS | 2.796585e-01 | 0.553 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.237371e-01 | 0.490 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.237371e-01 | 0.490 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 8.749593e-02 | 1.058 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.327220e-01 | 0.633 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.406075e-01 | 0.468 |
| R-HSA-5689603 | UCH proteinases | 9.097494e-02 | 1.041 |
| R-HSA-9675135 | Diseases of DNA repair | 1.489539e-01 | 0.827 |
| R-HSA-389542 | NADPH regeneration | 1.072858e-01 | 0.969 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.295258e-01 | 0.888 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.512144e-01 | 0.820 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.827431e-01 | 0.738 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.976230e-01 | 0.526 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.045049e-01 | 0.516 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.986874e-01 | 0.702 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.690906e-01 | 0.772 |
| R-HSA-437239 | Recycling pathway of L1 | 1.533139e-01 | 0.814 |
| R-HSA-164944 | Nef and signal transduction | 1.072858e-01 | 0.969 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.827431e-01 | 0.738 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.827431e-01 | 0.738 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.827431e-01 | 0.738 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.031120e-01 | 0.692 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.131062e-01 | 0.671 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.131062e-01 | 0.671 |
| R-HSA-190828 | Gap junction trafficking | 1.403135e-01 | 0.853 |
| R-HSA-200425 | Carnitine shuttle | 3.064373e-01 | 0.514 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.766748e-01 | 0.558 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.327220e-01 | 0.633 |
| R-HSA-201451 | Signaling by BMP | 3.406075e-01 | 0.468 |
| R-HSA-73894 | DNA Repair | 2.058247e-01 | 0.687 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.404382e-01 | 0.853 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 1.512144e-01 | 0.820 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.031120e-01 | 0.692 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.327220e-01 | 0.633 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.796585e-01 | 0.553 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 2.886972e-01 | 0.540 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.621068e-01 | 0.790 |
| R-HSA-109704 | PI3K Cascade | 1.665371e-01 | 0.778 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.064373e-01 | 0.514 |
| R-HSA-2160916 | Hyaluronan degradation | 3.237371e-01 | 0.490 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.322253e-01 | 0.479 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.322253e-01 | 0.479 |
| R-HSA-9659379 | Sensory processing of sound | 2.998766e-01 | 0.523 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.529850e-01 | 0.597 |
| R-HSA-210990 | PECAM1 interactions | 1.618562e-01 | 0.791 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 2.976230e-01 | 0.526 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.487879e-01 | 0.604 |
| R-HSA-69275 | G2/M Transition | 1.190894e-01 | 0.924 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.252929e-01 | 0.902 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.796585e-01 | 0.553 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.720268e-01 | 0.565 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.226420e-01 | 0.911 |
| R-HSA-4839726 | Chromatin organization | 2.532066e-01 | 0.597 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.450631e-01 | 0.838 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.745932e-01 | 0.561 |
| R-HSA-1640170 | Cell Cycle | 1.334244e-01 | 0.875 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.929915e-01 | 0.714 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.031120e-01 | 0.692 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 2.518511e-01 | 0.599 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 2.705056e-01 | 0.568 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.935172e-01 | 0.713 |
| R-HSA-68886 | M Phase | 1.392625e-01 | 0.856 |
| R-HSA-201556 | Signaling by ALK | 1.151299e-01 | 0.939 |
| R-HSA-3214842 | HDMs demethylate histones | 3.237371e-01 | 0.490 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.301524e-01 | 0.638 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.008038e-01 | 0.697 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.404382e-01 | 0.853 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.518511e-01 | 0.599 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.533139e-01 | 0.814 |
| R-HSA-112399 | IRS-mediated signalling | 1.980696e-01 | 0.703 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.406075e-01 | 0.468 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.886972e-01 | 0.540 |
| R-HSA-373755 | Semaphorin interactions | 2.256215e-01 | 0.647 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.329500e-01 | 0.633 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.186069e-01 | 0.660 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.793286e-01 | 0.746 |
| R-HSA-74182 | Ketone body metabolism | 3.064373e-01 | 0.514 |
| R-HSA-114608 | Platelet degranulation | 2.664785e-01 | 0.574 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.087639e-01 | 0.680 |
| R-HSA-6807070 | PTEN Regulation | 3.142351e-01 | 0.503 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.163989e-01 | 0.665 |
| R-HSA-194138 | Signaling by VEGF | 1.022853e-01 | 0.990 |
| R-HSA-435354 | Zinc transporters | 2.031120e-01 | 0.692 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.039580e-01 | 0.517 |
| R-HSA-8848021 | Signaling by PTK6 | 2.256215e-01 | 0.647 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.256215e-01 | 0.647 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.064373e-01 | 0.514 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.902823e-01 | 0.537 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.070870e-01 | 0.513 |
| R-HSA-8983711 | OAS antiviral response | 1.827431e-01 | 0.738 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.045049e-01 | 0.516 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.907244e-01 | 0.720 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.576986e-01 | 0.802 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.885097e-01 | 0.725 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.567610e-01 | 0.805 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.302440e-01 | 0.638 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 9.516925e-02 | 1.022 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.110557e-01 | 0.954 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.907244e-01 | 0.720 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.064373e-01 | 0.514 |
| R-HSA-8854691 | Interleukin-20 family signaling | 3.064373e-01 | 0.514 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.612369e-01 | 0.583 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.348728e-01 | 0.629 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.064373e-01 | 0.514 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.766748e-01 | 0.558 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.813211e-01 | 0.551 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.754593e-01 | 0.756 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.302440e-01 | 0.638 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.403135e-01 | 0.853 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.518511e-01 | 0.599 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.091276e-01 | 0.510 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.976230e-01 | 0.526 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.367170e-01 | 0.473 |
| R-HSA-1474244 | Extracellular matrix organization | 1.572603e-01 | 0.803 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.412857e-01 | 0.467 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.416623e-01 | 0.466 |
| R-HSA-68882 | Mitotic Anaphase | 3.471437e-01 | 0.459 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.488849e-01 | 0.457 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.488849e-01 | 0.457 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.499887e-01 | 0.456 |
| R-HSA-112310 | Neurotransmitter release cycle | 3.549314e-01 | 0.450 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.553555e-01 | 0.449 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.570590e-01 | 0.447 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.570590e-01 | 0.447 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.639736e-01 | 0.439 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.651310e-01 | 0.438 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.651310e-01 | 0.438 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.684769e-01 | 0.434 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.684769e-01 | 0.434 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.731021e-01 | 0.428 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.731021e-01 | 0.428 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.731021e-01 | 0.428 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.731021e-01 | 0.428 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.731021e-01 | 0.428 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.774460e-01 | 0.423 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.792245e-01 | 0.421 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.809736e-01 | 0.419 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.809736e-01 | 0.419 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.809736e-01 | 0.419 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.809736e-01 | 0.419 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.812723e-01 | 0.419 |
| R-HSA-9711097 | Cellular response to starvation | 3.826208e-01 | 0.417 |
| R-HSA-877300 | Interferon gamma signaling | 3.860131e-01 | 0.413 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.887467e-01 | 0.410 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.887467e-01 | 0.410 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.887467e-01 | 0.410 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.887467e-01 | 0.410 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.887467e-01 | 0.410 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.887467e-01 | 0.410 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.887467e-01 | 0.410 |
| R-HSA-1296071 | Potassium Channels | 3.907998e-01 | 0.408 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.964227e-01 | 0.402 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.964227e-01 | 0.402 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.964227e-01 | 0.402 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.964227e-01 | 0.402 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.964227e-01 | 0.402 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.964227e-01 | 0.402 |
| R-HSA-913531 | Interferon Signaling | 4.005460e-01 | 0.397 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.040028e-01 | 0.394 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.040028e-01 | 0.394 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.040028e-01 | 0.394 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.040028e-01 | 0.394 |
| R-HSA-5673000 | RAF activation | 4.040028e-01 | 0.394 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.040028e-01 | 0.394 |
| R-HSA-3214847 | HATs acetylate histones | 4.040253e-01 | 0.394 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.084037e-01 | 0.389 |
| R-HSA-70171 | Glycolysis | 4.084037e-01 | 0.389 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.114882e-01 | 0.386 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.114882e-01 | 0.386 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.114882e-01 | 0.386 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.143382e-01 | 0.383 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.171136e-01 | 0.380 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.171136e-01 | 0.380 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.171136e-01 | 0.380 |
| R-HSA-1483255 | PI Metabolism | 4.171136e-01 | 0.380 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.188800e-01 | 0.378 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.188800e-01 | 0.378 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.188800e-01 | 0.378 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.188800e-01 | 0.378 |
| R-HSA-112316 | Neuronal System | 4.204980e-01 | 0.376 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.257589e-01 | 0.371 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.261794e-01 | 0.370 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.261794e-01 | 0.370 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.261794e-01 | 0.370 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.333876e-01 | 0.363 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.333876e-01 | 0.363 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.348618e-01 | 0.362 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.348618e-01 | 0.362 |
| R-HSA-109582 | Hemostasis | 4.359372e-01 | 0.361 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.405056e-01 | 0.356 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.405056e-01 | 0.356 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.405056e-01 | 0.356 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.405056e-01 | 0.356 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.405056e-01 | 0.356 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.475347e-01 | 0.349 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.475347e-01 | 0.349 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.475347e-01 | 0.349 |
| R-HSA-167169 | HIV Transcription Elongation | 4.475347e-01 | 0.349 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.475347e-01 | 0.349 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.475347e-01 | 0.349 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.475347e-01 | 0.349 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.475347e-01 | 0.349 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.475347e-01 | 0.349 |
| R-HSA-202433 | Generation of second messenger molecules | 4.475347e-01 | 0.349 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 4.475347e-01 | 0.349 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.475347e-01 | 0.349 |
| R-HSA-9607240 | FLT3 Signaling | 4.544759e-01 | 0.342 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.544759e-01 | 0.342 |
| R-HSA-9694548 | Maturation of spike protein | 4.544759e-01 | 0.342 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.544759e-01 | 0.342 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.544759e-01 | 0.342 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.613303e-01 | 0.336 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.613303e-01 | 0.336 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.613303e-01 | 0.336 |
| R-HSA-165159 | MTOR signalling | 4.680990e-01 | 0.330 |
| R-HSA-977444 | GABA B receptor activation | 4.680990e-01 | 0.330 |
| R-HSA-991365 | Activation of GABAB receptors | 4.680990e-01 | 0.330 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.680990e-01 | 0.330 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.680990e-01 | 0.330 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.720633e-01 | 0.326 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.720633e-01 | 0.326 |
| R-HSA-8854214 | TBC/RABGAPs | 4.747831e-01 | 0.324 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.747831e-01 | 0.324 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.789549e-01 | 0.320 |
| R-HSA-69236 | G1 Phase | 4.813836e-01 | 0.318 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.813836e-01 | 0.318 |
| R-HSA-9907900 | Proteasome assembly | 4.813836e-01 | 0.318 |
| R-HSA-2172127 | DAP12 interactions | 4.813836e-01 | 0.318 |
| R-HSA-373752 | Netrin-1 signaling | 4.813836e-01 | 0.318 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.843022e-01 | 0.315 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.879015e-01 | 0.312 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.879015e-01 | 0.312 |
| R-HSA-983712 | Ion channel transport | 4.881191e-01 | 0.311 |
| R-HSA-70326 | Glucose metabolism | 4.923638e-01 | 0.308 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.923638e-01 | 0.308 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.923638e-01 | 0.308 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.943379e-01 | 0.306 |
| R-HSA-75153 | Apoptotic execution phase | 4.943379e-01 | 0.306 |
| R-HSA-5693538 | Homology Directed Repair | 4.963649e-01 | 0.304 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.978422e-01 | 0.303 |
| R-HSA-1483191 | Synthesis of PC | 5.006938e-01 | 0.300 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.069703e-01 | 0.295 |
| R-HSA-425410 | Metal ion SLC transporters | 5.069703e-01 | 0.295 |
| R-HSA-3371556 | Cellular response to heat stress | 5.082478e-01 | 0.294 |
| R-HSA-73893 | DNA Damage Bypass | 5.131682e-01 | 0.290 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.160681e-01 | 0.287 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.224033e-01 | 0.282 |
| R-HSA-912446 | Meiotic recombination | 5.253323e-01 | 0.280 |
| R-HSA-69206 | G1/S Transition | 5.276440e-01 | 0.278 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.313005e-01 | 0.275 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.313005e-01 | 0.275 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.315369e-01 | 0.274 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.371940e-01 | 0.270 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.371940e-01 | 0.270 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.371940e-01 | 0.270 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.390322e-01 | 0.268 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.465191e-01 | 0.262 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.487607e-01 | 0.261 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.487607e-01 | 0.261 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.544357e-01 | 0.256 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.544357e-01 | 0.256 |
| R-HSA-75893 | TNF signaling | 5.544357e-01 | 0.256 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.544357e-01 | 0.256 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.600397e-01 | 0.252 |
| R-HSA-1483166 | Synthesis of PA | 5.600397e-01 | 0.252 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.600397e-01 | 0.252 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.612644e-01 | 0.251 |
| R-HSA-1483257 | Phospholipid metabolism | 5.627325e-01 | 0.250 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.641745e-01 | 0.249 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.655735e-01 | 0.248 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.710381e-01 | 0.243 |
| R-HSA-191859 | snRNP Assembly | 5.710381e-01 | 0.243 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.710381e-01 | 0.243 |
| R-HSA-977443 | GABA receptor activation | 5.764343e-01 | 0.239 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.817629e-01 | 0.235 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.826732e-01 | 0.235 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.861703e-01 | 0.232 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.870248e-01 | 0.231 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.870248e-01 | 0.231 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.870248e-01 | 0.231 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.870248e-01 | 0.231 |
| R-HSA-9664407 | Parasite infection | 5.896458e-01 | 0.229 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.896458e-01 | 0.229 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.896458e-01 | 0.229 |
| R-HSA-9679506 | SARS-CoV Infections | 5.917401e-01 | 0.228 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.930998e-01 | 0.227 |
| R-HSA-1632852 | Macroautophagy | 5.930998e-01 | 0.227 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 5.973519e-01 | 0.224 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.999428e-01 | 0.222 |
| R-HSA-1266738 | Developmental Biology | 6.007448e-01 | 0.221 |
| R-HSA-162906 | HIV Infection | 6.036646e-01 | 0.219 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.074219e-01 | 0.217 |
| R-HSA-199991 | Membrane Trafficking | 6.097609e-01 | 0.215 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.123625e-01 | 0.213 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.123625e-01 | 0.213 |
| R-HSA-167172 | Transcription of the HIV genome | 6.172412e-01 | 0.210 |
| R-HSA-166520 | Signaling by NTRKs | 6.199535e-01 | 0.208 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.264512e-01 | 0.203 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.268162e-01 | 0.203 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.268162e-01 | 0.203 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.268162e-01 | 0.203 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.268162e-01 | 0.203 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.268162e-01 | 0.203 |
| R-HSA-8939211 | ESR-mediated signaling | 6.303978e-01 | 0.200 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.315139e-01 | 0.200 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.315139e-01 | 0.200 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.315139e-01 | 0.200 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.315139e-01 | 0.200 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.315139e-01 | 0.200 |
| R-HSA-8978934 | Metabolism of cofactors | 6.315139e-01 | 0.200 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.328629e-01 | 0.199 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.328629e-01 | 0.199 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.361528e-01 | 0.196 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.361528e-01 | 0.196 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.361528e-01 | 0.196 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.391888e-01 | 0.194 |
| R-HSA-73887 | Death Receptor Signaling | 6.391888e-01 | 0.194 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.407335e-01 | 0.193 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.407335e-01 | 0.193 |
| R-HSA-1989781 | PPARA activates gene expression | 6.423197e-01 | 0.192 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.452569e-01 | 0.190 |
| R-HSA-9612973 | Autophagy | 6.454293e-01 | 0.190 |
| R-HSA-162587 | HIV Life Cycle | 6.485176e-01 | 0.188 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.497236e-01 | 0.187 |
| R-HSA-8852135 | Protein ubiquitination | 6.497236e-01 | 0.187 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.497236e-01 | 0.187 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.541343e-01 | 0.184 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.576550e-01 | 0.182 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.584897e-01 | 0.181 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.627906e-01 | 0.179 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.627906e-01 | 0.179 |
| R-HSA-4086400 | PCP/CE pathway | 6.627906e-01 | 0.179 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.627906e-01 | 0.179 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.627906e-01 | 0.179 |
| R-HSA-216083 | Integrin cell surface interactions | 6.627906e-01 | 0.179 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.753725e-01 | 0.170 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.768389e-01 | 0.170 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.777026e-01 | 0.169 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.794617e-01 | 0.168 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.834997e-01 | 0.165 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.874871e-01 | 0.163 |
| R-HSA-1500620 | Meiosis | 6.914245e-01 | 0.160 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.914245e-01 | 0.160 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.953125e-01 | 0.158 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.978096e-01 | 0.156 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.005239e-01 | 0.155 |
| R-HSA-74160 | Gene expression (Transcription) | 7.028468e-01 | 0.153 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.029430e-01 | 0.153 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 7.066865e-01 | 0.151 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.176380e-01 | 0.144 |
| R-HSA-6798695 | Neutrophil degranulation | 7.224364e-01 | 0.141 |
| R-HSA-391251 | Protein folding | 7.247119e-01 | 0.140 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.247119e-01 | 0.140 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.281824e-01 | 0.138 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.316094e-01 | 0.136 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.350018e-01 | 0.134 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.416346e-01 | 0.130 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.512871e-01 | 0.124 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.512871e-01 | 0.124 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.513721e-01 | 0.124 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.605807e-01 | 0.119 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.642623e-01 | 0.117 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.665836e-01 | 0.115 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.686443e-01 | 0.114 |
| R-HSA-9833110 | RSV-host interactions | 7.695286e-01 | 0.114 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 7.695286e-01 | 0.114 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.708087e-01 | 0.113 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.724367e-01 | 0.112 |
| R-HSA-418346 | Platelet homeostasis | 7.753083e-01 | 0.111 |
| R-HSA-211000 | Gene Silencing by RNA | 7.781438e-01 | 0.109 |
| R-HSA-212436 | Generic Transcription Pathway | 7.809018e-01 | 0.107 |
| R-HSA-202403 | TCR signaling | 7.864384e-01 | 0.104 |
| R-HSA-6803157 | Antimicrobial peptides | 7.891341e-01 | 0.103 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.917959e-01 | 0.101 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.021131e-01 | 0.096 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.021131e-01 | 0.096 |
| R-HSA-68875 | Mitotic Prophase | 8.166426e-01 | 0.088 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.247544e-01 | 0.084 |
| R-HSA-69481 | G2/M Checkpoints | 8.343769e-01 | 0.079 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.362022e-01 | 0.078 |
| R-HSA-157118 | Signaling by NOTCH | 8.409440e-01 | 0.075 |
| R-HSA-1474165 | Reproduction | 8.425931e-01 | 0.074 |
| R-HSA-9843745 | Adipogenesis | 8.445830e-01 | 0.073 |
| R-HSA-9717189 | Sensory perception of taste | 8.445830e-01 | 0.073 |
| R-HSA-5576891 | Cardiac conduction | 8.445830e-01 | 0.073 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.465478e-01 | 0.072 |
| R-HSA-2262752 | Cellular responses to stress | 8.492452e-01 | 0.071 |
| R-HSA-8953854 | Metabolism of RNA | 8.499421e-01 | 0.071 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.560073e-01 | 0.068 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.578283e-01 | 0.067 |
| R-HSA-597592 | Post-translational protein modification | 8.601275e-01 | 0.065 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.632715e-01 | 0.064 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.754970e-01 | 0.058 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.764090e-01 | 0.057 |
| R-HSA-69242 | S Phase | 8.779732e-01 | 0.057 |
| R-HSA-9758941 | Gastrulation | 8.795177e-01 | 0.056 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.795617e-01 | 0.056 |
| R-HSA-69306 | DNA Replication | 8.855037e-01 | 0.053 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.869534e-01 | 0.052 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.883848e-01 | 0.051 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.894348e-01 | 0.051 |
| R-HSA-9610379 | HCMV Late Events | 8.911937e-01 | 0.050 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.922229e-01 | 0.050 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.925716e-01 | 0.049 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.943885e-01 | 0.048 |
| R-HSA-9658195 | Leishmania infection | 8.943885e-01 | 0.048 |
| R-HSA-109581 | Apoptosis | 8.979120e-01 | 0.047 |
| R-HSA-5619102 | SLC transporter disorders | 9.042174e-01 | 0.044 |
| R-HSA-72306 | tRNA processing | 9.089815e-01 | 0.041 |
| R-HSA-195721 | Signaling by WNT | 9.112325e-01 | 0.040 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.112743e-01 | 0.040 |
| R-HSA-449147 | Signaling by Interleukins | 9.127585e-01 | 0.040 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.146063e-01 | 0.039 |
| R-HSA-168255 | Influenza Infection | 9.188559e-01 | 0.037 |
| R-HSA-2559583 | Cellular Senescence | 9.198851e-01 | 0.036 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.228951e-01 | 0.035 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.257926e-01 | 0.033 |
| R-HSA-1280218 | Adaptive Immune System | 9.261220e-01 | 0.033 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.303830e-01 | 0.031 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.321390e-01 | 0.031 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.330004e-01 | 0.030 |
| R-HSA-9609690 | HCMV Early Events | 9.346907e-01 | 0.029 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.406968e-01 | 0.027 |
| R-HSA-72172 | mRNA Splicing | 9.417870e-01 | 0.026 |
| R-HSA-5357801 | Programmed Cell Death | 9.425265e-01 | 0.026 |
| R-HSA-8951664 | Neddylation | 9.531635e-01 | 0.021 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.556025e-01 | 0.020 |
| R-HSA-9824446 | Viral Infection Pathways | 9.566285e-01 | 0.019 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.577226e-01 | 0.019 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.582605e-01 | 0.019 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.664296e-01 | 0.015 |
| R-HSA-9609646 | HCMV Infection | 9.676962e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.692299e-01 | 0.014 |
| R-HSA-418594 | G alpha (i) signalling events | 9.724057e-01 | 0.012 |
| R-HSA-416476 | G alpha (q) signalling events | 9.730062e-01 | 0.012 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.765860e-01 | 0.010 |
| R-HSA-168249 | Innate Immune System | 9.785321e-01 | 0.009 |
| R-HSA-168256 | Immune System | 9.881284e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.899750e-01 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 9.910855e-01 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.950095e-01 | 0.002 |
| R-HSA-1643685 | Disease | 9.953826e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.957825e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.960162e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.960731e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.964574e-01 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 9.969217e-01 | 0.001 |
| R-HSA-5663205 | Infectious disease | 9.969262e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.989997e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999888e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.887 | 0.183 | 2 | 0.856 |
CLK3 |
0.880 | 0.254 | 1 | 0.881 |
CDC7 |
0.877 | 0.081 | 1 | 0.856 |
MOS |
0.876 | 0.147 | 1 | 0.894 |
PIM3 |
0.874 | 0.080 | -3 | 0.813 |
NDR2 |
0.871 | 0.055 | -3 | 0.814 |
PRPK |
0.871 | -0.090 | -1 | 0.888 |
HIPK4 |
0.871 | 0.199 | 1 | 0.871 |
NLK |
0.870 | 0.140 | 1 | 0.890 |
ERK5 |
0.868 | 0.131 | 1 | 0.820 |
IKKB |
0.868 | -0.057 | -2 | 0.766 |
MTOR |
0.867 | -0.032 | 1 | 0.797 |
CAMK2G |
0.867 | -0.014 | 2 | 0.823 |
RAF1 |
0.866 | -0.051 | 1 | 0.823 |
ATR |
0.866 | 0.030 | 1 | 0.846 |
CAMK1B |
0.865 | -0.006 | -3 | 0.850 |
DSTYK |
0.865 | -0.001 | 2 | 0.863 |
CDKL1 |
0.865 | 0.079 | -3 | 0.787 |
BMPR2 |
0.863 | -0.132 | -2 | 0.863 |
GCN2 |
0.863 | -0.181 | 2 | 0.802 |
SRPK1 |
0.863 | 0.117 | -3 | 0.730 |
ICK |
0.863 | 0.162 | -3 | 0.821 |
PDHK4 |
0.863 | -0.238 | 1 | 0.847 |
PRKD1 |
0.863 | 0.042 | -3 | 0.791 |
SKMLCK |
0.863 | 0.075 | -2 | 0.827 |
IKKA |
0.862 | 0.016 | -2 | 0.758 |
CDK8 |
0.861 | 0.186 | 1 | 0.772 |
TBK1 |
0.861 | -0.112 | 1 | 0.702 |
ULK2 |
0.861 | -0.163 | 2 | 0.772 |
GRK1 |
0.861 | 0.062 | -2 | 0.747 |
GRK6 |
0.861 | 0.056 | 1 | 0.836 |
GRK5 |
0.860 | -0.073 | -3 | 0.884 |
RSK2 |
0.860 | 0.043 | -3 | 0.745 |
CDKL5 |
0.860 | 0.096 | -3 | 0.774 |
JNK2 |
0.860 | 0.277 | 1 | 0.725 |
RIPK3 |
0.860 | 0.009 | 3 | 0.774 |
DYRK2 |
0.859 | 0.207 | 1 | 0.811 |
KIS |
0.859 | 0.139 | 1 | 0.789 |
IKKE |
0.858 | -0.119 | 1 | 0.691 |
PIM1 |
0.858 | 0.058 | -3 | 0.750 |
NDR1 |
0.858 | -0.023 | -3 | 0.803 |
PDHK1 |
0.858 | -0.225 | 1 | 0.829 |
CAMLCK |
0.858 | -0.009 | -2 | 0.838 |
CDK1 |
0.857 | 0.220 | 1 | 0.739 |
P90RSK |
0.857 | 0.009 | -3 | 0.749 |
CDK19 |
0.857 | 0.193 | 1 | 0.739 |
CDK7 |
0.856 | 0.174 | 1 | 0.780 |
JNK3 |
0.856 | 0.242 | 1 | 0.753 |
CHAK2 |
0.856 | -0.029 | -1 | 0.872 |
DAPK2 |
0.856 | -0.016 | -3 | 0.859 |
MLK1 |
0.856 | -0.095 | 2 | 0.786 |
NIK |
0.856 | -0.095 | -3 | 0.870 |
PRKD2 |
0.856 | 0.028 | -3 | 0.727 |
CAMK2D |
0.855 | -0.028 | -3 | 0.821 |
LATS2 |
0.855 | -0.003 | -5 | 0.817 |
NEK6 |
0.854 | -0.105 | -2 | 0.815 |
CDK18 |
0.854 | 0.221 | 1 | 0.718 |
FAM20C |
0.854 | 0.045 | 2 | 0.604 |
P38B |
0.854 | 0.264 | 1 | 0.719 |
PKN3 |
0.853 | -0.074 | -3 | 0.808 |
BMPR1B |
0.853 | 0.136 | 1 | 0.799 |
NEK7 |
0.853 | -0.186 | -3 | 0.858 |
CAMK2B |
0.853 | 0.044 | 2 | 0.808 |
MAPKAPK2 |
0.853 | 0.031 | -3 | 0.679 |
CAMK2A |
0.853 | 0.065 | 2 | 0.827 |
ATM |
0.853 | 0.026 | 1 | 0.788 |
DLK |
0.853 | -0.063 | 1 | 0.822 |
WNK1 |
0.852 | -0.084 | -2 | 0.856 |
MAPKAPK3 |
0.852 | -0.028 | -3 | 0.731 |
TGFBR2 |
0.852 | -0.098 | -2 | 0.740 |
MLK2 |
0.852 | -0.039 | 2 | 0.802 |
TGFBR1 |
0.851 | 0.068 | -2 | 0.763 |
P38A |
0.851 | 0.231 | 1 | 0.784 |
MASTL |
0.851 | -0.218 | -2 | 0.814 |
ULK1 |
0.851 | -0.191 | -3 | 0.821 |
MARK4 |
0.850 | -0.077 | 4 | 0.819 |
RSK3 |
0.850 | -0.022 | -3 | 0.739 |
SRPK2 |
0.850 | 0.065 | -3 | 0.649 |
ALK4 |
0.850 | 0.022 | -2 | 0.798 |
CDK5 |
0.850 | 0.180 | 1 | 0.797 |
GRK4 |
0.850 | -0.106 | -2 | 0.770 |
BCKDK |
0.849 | -0.180 | -1 | 0.842 |
CDK13 |
0.849 | 0.138 | 1 | 0.753 |
DYRK4 |
0.849 | 0.233 | 1 | 0.744 |
HUNK |
0.849 | -0.172 | 2 | 0.839 |
P70S6KB |
0.849 | -0.035 | -3 | 0.769 |
PKCD |
0.848 | -0.032 | 2 | 0.759 |
MLK3 |
0.848 | -0.012 | 2 | 0.718 |
TSSK2 |
0.848 | -0.040 | -5 | 0.850 |
MST4 |
0.848 | -0.082 | 2 | 0.804 |
CLK2 |
0.848 | 0.195 | -3 | 0.723 |
NUAK2 |
0.848 | -0.075 | -3 | 0.817 |
RSK4 |
0.848 | 0.050 | -3 | 0.712 |
CDK17 |
0.848 | 0.194 | 1 | 0.670 |
P38G |
0.848 | 0.211 | 1 | 0.661 |
P38D |
0.847 | 0.263 | 1 | 0.685 |
CLK4 |
0.847 | 0.090 | -3 | 0.743 |
NEK9 |
0.847 | -0.177 | 2 | 0.793 |
ERK1 |
0.846 | 0.201 | 1 | 0.715 |
RIPK1 |
0.846 | -0.143 | 1 | 0.809 |
PKACG |
0.846 | -0.042 | -2 | 0.723 |
LATS1 |
0.846 | 0.046 | -3 | 0.831 |
ANKRD3 |
0.846 | -0.149 | 1 | 0.844 |
HIPK2 |
0.846 | 0.194 | 1 | 0.737 |
PKN2 |
0.846 | -0.081 | -3 | 0.813 |
PAK1 |
0.845 | -0.029 | -2 | 0.780 |
PKR |
0.845 | -0.028 | 1 | 0.849 |
AURC |
0.845 | 0.021 | -2 | 0.637 |
ACVR2B |
0.845 | 0.047 | -2 | 0.757 |
SMG1 |
0.845 | -0.006 | 1 | 0.800 |
SRPK3 |
0.844 | 0.038 | -3 | 0.711 |
AMPKA1 |
0.844 | -0.097 | -3 | 0.825 |
CDK2 |
0.844 | 0.110 | 1 | 0.806 |
ALK2 |
0.844 | 0.056 | -2 | 0.763 |
PLK1 |
0.844 | -0.079 | -2 | 0.781 |
MEK1 |
0.844 | -0.111 | 2 | 0.849 |
DNAPK |
0.844 | 0.055 | 1 | 0.704 |
WNK3 |
0.843 | -0.288 | 1 | 0.807 |
MSK2 |
0.843 | -0.047 | -3 | 0.714 |
VRK2 |
0.843 | -0.111 | 1 | 0.892 |
CDK3 |
0.843 | 0.192 | 1 | 0.688 |
ERK2 |
0.843 | 0.157 | 1 | 0.755 |
ACVR2A |
0.843 | 0.006 | -2 | 0.744 |
MSK1 |
0.842 | 0.017 | -3 | 0.711 |
PRP4 |
0.842 | 0.109 | -3 | 0.762 |
GRK7 |
0.842 | 0.034 | 1 | 0.768 |
MLK4 |
0.842 | -0.042 | 2 | 0.712 |
PAK3 |
0.842 | -0.080 | -2 | 0.782 |
HIPK1 |
0.842 | 0.153 | 1 | 0.824 |
IRE1 |
0.841 | -0.112 | 1 | 0.798 |
PLK3 |
0.841 | -0.044 | 2 | 0.801 |
CLK1 |
0.841 | 0.086 | -3 | 0.716 |
CDK9 |
0.840 | 0.106 | 1 | 0.757 |
CAMK4 |
0.840 | -0.126 | -3 | 0.795 |
DYRK1A |
0.840 | 0.139 | 1 | 0.826 |
CDK16 |
0.840 | 0.212 | 1 | 0.689 |
CDK12 |
0.840 | 0.128 | 1 | 0.726 |
TSSK1 |
0.840 | -0.065 | -3 | 0.846 |
TLK2 |
0.840 | -0.056 | 1 | 0.796 |
BMPR1A |
0.840 | 0.105 | 1 | 0.786 |
NIM1 |
0.840 | -0.155 | 3 | 0.769 |
PRKD3 |
0.839 | -0.036 | -3 | 0.717 |
TTBK2 |
0.839 | -0.219 | 2 | 0.692 |
PKACB |
0.839 | 0.028 | -2 | 0.651 |
JNK1 |
0.839 | 0.227 | 1 | 0.716 |
MNK2 |
0.839 | -0.049 | -2 | 0.782 |
MYLK4 |
0.838 | -0.017 | -2 | 0.744 |
CDK14 |
0.838 | 0.180 | 1 | 0.756 |
IRE2 |
0.838 | -0.074 | 2 | 0.705 |
PASK |
0.838 | 0.115 | -3 | 0.839 |
AMPKA2 |
0.838 | -0.089 | -3 | 0.785 |
YSK4 |
0.838 | -0.131 | 1 | 0.741 |
BRAF |
0.837 | -0.024 | -4 | 0.825 |
DRAK1 |
0.837 | -0.018 | 1 | 0.739 |
CHK1 |
0.837 | -0.054 | -3 | 0.775 |
PKCG |
0.836 | -0.076 | 2 | 0.712 |
AURB |
0.836 | -0.017 | -2 | 0.637 |
PKCA |
0.836 | -0.058 | 2 | 0.692 |
PAK6 |
0.836 | -0.016 | -2 | 0.718 |
DYRK1B |
0.835 | 0.145 | 1 | 0.761 |
PAK2 |
0.835 | -0.091 | -2 | 0.767 |
AURA |
0.835 | -0.013 | -2 | 0.601 |
PKCB |
0.834 | -0.067 | 2 | 0.696 |
PIM2 |
0.834 | -0.001 | -3 | 0.717 |
CHAK1 |
0.834 | -0.173 | 2 | 0.757 |
QSK |
0.834 | -0.071 | 4 | 0.796 |
NEK2 |
0.834 | -0.174 | 2 | 0.761 |
MELK |
0.834 | -0.111 | -3 | 0.771 |
AKT2 |
0.833 | 0.007 | -3 | 0.660 |
MNK1 |
0.833 | -0.050 | -2 | 0.796 |
PKG2 |
0.833 | -0.020 | -2 | 0.663 |
HIPK3 |
0.833 | 0.105 | 1 | 0.809 |
DYRK3 |
0.833 | 0.118 | 1 | 0.828 |
GSK3A |
0.833 | 0.083 | 4 | 0.457 |
PRKX |
0.833 | 0.043 | -3 | 0.637 |
PINK1 |
0.832 | -0.114 | 1 | 0.869 |
QIK |
0.832 | -0.178 | -3 | 0.824 |
GRK2 |
0.832 | -0.068 | -2 | 0.680 |
BRSK1 |
0.832 | -0.099 | -3 | 0.762 |
PKCZ |
0.832 | -0.104 | 2 | 0.737 |
MARK3 |
0.832 | -0.046 | 4 | 0.748 |
MPSK1 |
0.831 | 0.105 | 1 | 0.818 |
CDK10 |
0.831 | 0.161 | 1 | 0.746 |
SIK |
0.831 | -0.090 | -3 | 0.732 |
NUAK1 |
0.831 | -0.112 | -3 | 0.757 |
GSK3B |
0.830 | 0.022 | 4 | 0.448 |
PERK |
0.830 | -0.180 | -2 | 0.793 |
BRSK2 |
0.829 | -0.131 | -3 | 0.788 |
CK2A2 |
0.829 | 0.097 | 1 | 0.727 |
MARK2 |
0.829 | -0.085 | 4 | 0.716 |
PKCH |
0.829 | -0.125 | 2 | 0.690 |
MEK5 |
0.828 | -0.256 | 2 | 0.819 |
PHKG1 |
0.828 | -0.155 | -3 | 0.797 |
GAK |
0.828 | 0.102 | 1 | 0.866 |
MAK |
0.828 | 0.241 | -2 | 0.837 |
MEKK3 |
0.828 | -0.168 | 1 | 0.786 |
NEK5 |
0.827 | -0.114 | 1 | 0.821 |
ZAK |
0.827 | -0.155 | 1 | 0.762 |
CAMKK1 |
0.827 | -0.042 | -2 | 0.794 |
CK1E |
0.827 | -0.009 | -3 | 0.610 |
MEKK1 |
0.827 | -0.187 | 1 | 0.807 |
HRI |
0.827 | -0.230 | -2 | 0.814 |
PLK4 |
0.827 | -0.159 | 2 | 0.667 |
LKB1 |
0.827 | 0.023 | -3 | 0.839 |
SMMLCK |
0.826 | -0.050 | -3 | 0.801 |
MEKK2 |
0.826 | -0.143 | 2 | 0.787 |
PDHK3_TYR |
0.826 | 0.334 | 4 | 0.895 |
CAMK1G |
0.826 | -0.074 | -3 | 0.740 |
SNRK |
0.826 | -0.226 | 2 | 0.694 |
DCAMKL1 |
0.826 | -0.078 | -3 | 0.748 |
MAPKAPK5 |
0.826 | -0.159 | -3 | 0.688 |
TLK1 |
0.825 | -0.134 | -2 | 0.767 |
SGK3 |
0.825 | -0.066 | -3 | 0.726 |
CAMKK2 |
0.824 | -0.036 | -2 | 0.798 |
MARK1 |
0.824 | -0.111 | 4 | 0.766 |
IRAK4 |
0.824 | -0.130 | 1 | 0.798 |
PKACA |
0.823 | -0.004 | -2 | 0.604 |
DCAMKL2 |
0.823 | -0.081 | -3 | 0.777 |
CDK6 |
0.823 | 0.146 | 1 | 0.738 |
MST3 |
0.822 | -0.092 | 2 | 0.803 |
CK2A1 |
0.822 | 0.091 | 1 | 0.702 |
CDK4 |
0.821 | 0.145 | 1 | 0.721 |
ERK7 |
0.821 | 0.008 | 2 | 0.480 |
PLK2 |
0.820 | 0.008 | -3 | 0.794 |
TAO3 |
0.820 | -0.123 | 1 | 0.779 |
WNK4 |
0.819 | -0.222 | -2 | 0.852 |
CAMK1D |
0.819 | -0.047 | -3 | 0.651 |
MOK |
0.819 | 0.174 | 1 | 0.818 |
CK1D |
0.819 | -0.007 | -3 | 0.563 |
P70S6K |
0.818 | -0.091 | -3 | 0.675 |
DAPK3 |
0.818 | -0.023 | -3 | 0.774 |
CK1G1 |
0.817 | -0.051 | -3 | 0.610 |
GRK3 |
0.817 | -0.070 | -2 | 0.620 |
AKT1 |
0.817 | -0.026 | -3 | 0.671 |
SSTK |
0.817 | -0.094 | 4 | 0.770 |
PDHK4_TYR |
0.817 | 0.181 | 2 | 0.895 |
TTBK1 |
0.817 | -0.183 | 2 | 0.628 |
EEF2K |
0.817 | -0.045 | 3 | 0.834 |
TAK1 |
0.816 | -0.048 | 1 | 0.807 |
CK1A2 |
0.816 | -0.010 | -3 | 0.561 |
MST2 |
0.816 | -0.094 | 1 | 0.785 |
NEK8 |
0.816 | -0.213 | 2 | 0.783 |
PKCT |
0.815 | -0.126 | 2 | 0.697 |
GCK |
0.815 | -0.055 | 1 | 0.775 |
NEK11 |
0.815 | -0.208 | 1 | 0.762 |
MAP2K6_TYR |
0.815 | 0.132 | -1 | 0.914 |
PAK5 |
0.815 | -0.071 | -2 | 0.648 |
PAK4 |
0.815 | -0.050 | -2 | 0.651 |
TAO2 |
0.814 | -0.172 | 2 | 0.805 |
IRAK1 |
0.814 | -0.260 | -1 | 0.803 |
MAP2K4_TYR |
0.813 | 0.046 | -1 | 0.905 |
NEK4 |
0.813 | -0.156 | 1 | 0.776 |
PHKG2 |
0.813 | -0.162 | -3 | 0.772 |
PDK1 |
0.812 | -0.162 | 1 | 0.772 |
DAPK1 |
0.812 | -0.033 | -3 | 0.760 |
TESK1_TYR |
0.811 | -0.025 | 3 | 0.867 |
PKCI |
0.811 | -0.129 | 2 | 0.698 |
STK33 |
0.811 | -0.129 | 2 | 0.658 |
PDHK1_TYR |
0.811 | 0.076 | -1 | 0.928 |
SBK |
0.810 | 0.014 | -3 | 0.530 |
PKCE |
0.810 | -0.072 | 2 | 0.690 |
LRRK2 |
0.810 | -0.191 | 2 | 0.809 |
VRK1 |
0.810 | -0.150 | 2 | 0.807 |
TNIK |
0.809 | -0.086 | 3 | 0.852 |
HGK |
0.809 | -0.122 | 3 | 0.849 |
NEK1 |
0.809 | -0.119 | 1 | 0.792 |
PBK |
0.809 | 0.035 | 1 | 0.790 |
MAP3K15 |
0.809 | -0.157 | 1 | 0.741 |
EPHA6 |
0.809 | 0.132 | -1 | 0.915 |
BMPR2_TYR |
0.809 | 0.064 | -1 | 0.904 |
AKT3 |
0.808 | 0.000 | -3 | 0.587 |
MAP2K7_TYR |
0.808 | -0.165 | 2 | 0.864 |
MEKK6 |
0.807 | -0.189 | 1 | 0.772 |
MINK |
0.807 | -0.148 | 1 | 0.760 |
EPHB4 |
0.807 | 0.112 | -1 | 0.904 |
PKMYT1_TYR |
0.807 | -0.092 | 3 | 0.837 |
MRCKA |
0.807 | -0.029 | -3 | 0.719 |
MST1 |
0.806 | -0.129 | 1 | 0.762 |
HPK1 |
0.806 | -0.102 | 1 | 0.749 |
LIMK2_TYR |
0.806 | 0.001 | -3 | 0.877 |
LOK |
0.805 | -0.133 | -2 | 0.781 |
MRCKB |
0.805 | -0.035 | -3 | 0.705 |
BUB1 |
0.805 | 0.016 | -5 | 0.797 |
SGK1 |
0.805 | -0.024 | -3 | 0.569 |
CHK2 |
0.805 | -0.061 | -3 | 0.597 |
SLK |
0.804 | -0.116 | -2 | 0.724 |
ROCK2 |
0.804 | -0.027 | -3 | 0.750 |
MEK2 |
0.804 | -0.261 | 2 | 0.800 |
TXK |
0.803 | 0.156 | 1 | 0.846 |
KHS1 |
0.803 | -0.080 | 1 | 0.747 |
EPHA4 |
0.802 | 0.094 | 2 | 0.816 |
PKN1 |
0.802 | -0.112 | -3 | 0.694 |
CAMK1A |
0.802 | -0.063 | -3 | 0.612 |
DMPK1 |
0.801 | 0.024 | -3 | 0.729 |
PINK1_TYR |
0.801 | -0.243 | 1 | 0.839 |
KHS2 |
0.800 | -0.065 | 1 | 0.762 |
YANK3 |
0.799 | -0.029 | 2 | 0.450 |
RET |
0.799 | -0.115 | 1 | 0.793 |
SRMS |
0.799 | 0.059 | 1 | 0.846 |
RIPK2 |
0.798 | -0.294 | 1 | 0.711 |
TTK |
0.798 | -0.059 | -2 | 0.765 |
MST1R |
0.797 | -0.101 | 3 | 0.803 |
OSR1 |
0.797 | -0.091 | 2 | 0.787 |
TYRO3 |
0.797 | -0.101 | 3 | 0.779 |
EPHB3 |
0.797 | 0.054 | -1 | 0.894 |
YES1 |
0.796 | 0.002 | -1 | 0.899 |
EPHB1 |
0.796 | 0.040 | 1 | 0.829 |
EPHB2 |
0.796 | 0.070 | -1 | 0.887 |
CSF1R |
0.796 | -0.038 | 3 | 0.783 |
DDR1 |
0.796 | -0.113 | 4 | 0.801 |
BIKE |
0.796 | 0.045 | 1 | 0.763 |
YSK1 |
0.796 | -0.195 | 2 | 0.757 |
LIMK1_TYR |
0.795 | -0.228 | 2 | 0.826 |
TNK2 |
0.795 | 0.012 | 3 | 0.759 |
ITK |
0.795 | 0.048 | -1 | 0.863 |
FER |
0.795 | -0.086 | 1 | 0.873 |
FGR |
0.794 | -0.058 | 1 | 0.850 |
ALPHAK3 |
0.793 | -0.022 | -1 | 0.816 |
ROS1 |
0.793 | -0.137 | 3 | 0.754 |
ABL2 |
0.793 | -0.026 | -1 | 0.869 |
JAK3 |
0.793 | -0.056 | 1 | 0.764 |
BLK |
0.793 | 0.099 | -1 | 0.892 |
JAK2 |
0.792 | -0.167 | 1 | 0.784 |
HCK |
0.792 | -0.026 | -1 | 0.888 |
TYK2 |
0.792 | -0.259 | 1 | 0.785 |
FGFR2 |
0.792 | -0.055 | 3 | 0.801 |
LCK |
0.791 | 0.048 | -1 | 0.889 |
EPHA7 |
0.791 | 0.047 | 2 | 0.807 |
CRIK |
0.790 | -0.036 | -3 | 0.665 |
PKG1 |
0.790 | -0.083 | -2 | 0.582 |
ABL1 |
0.790 | -0.046 | -1 | 0.860 |
NEK3 |
0.790 | -0.232 | 1 | 0.742 |
ASK1 |
0.789 | -0.176 | 1 | 0.728 |
MERTK |
0.789 | -0.031 | 3 | 0.773 |
TEK |
0.789 | -0.067 | 3 | 0.726 |
INSRR |
0.789 | -0.093 | 3 | 0.747 |
ROCK1 |
0.788 | -0.058 | -3 | 0.714 |
KIT |
0.788 | -0.072 | 3 | 0.788 |
EPHA3 |
0.788 | -0.014 | 2 | 0.790 |
AXL |
0.788 | -0.065 | 3 | 0.775 |
BMX |
0.788 | 0.015 | -1 | 0.775 |
MYO3B |
0.787 | -0.127 | 2 | 0.768 |
TNNI3K_TYR |
0.786 | -0.061 | 1 | 0.826 |
HASPIN |
0.786 | -0.084 | -1 | 0.684 |
FYN |
0.785 | 0.058 | -1 | 0.863 |
FGFR1 |
0.785 | -0.111 | 3 | 0.757 |
KDR |
0.785 | -0.076 | 3 | 0.760 |
EPHA5 |
0.785 | 0.042 | 2 | 0.810 |
MYO3A |
0.785 | -0.149 | 1 | 0.773 |
PDGFRB |
0.784 | -0.189 | 3 | 0.792 |
MET |
0.784 | -0.063 | 3 | 0.779 |
TEC |
0.783 | -0.043 | -1 | 0.797 |
FLT1 |
0.781 | -0.042 | -1 | 0.895 |
PTK2B |
0.781 | 0.001 | -1 | 0.834 |
EPHA1 |
0.781 | -0.058 | 3 | 0.762 |
FGFR3 |
0.781 | -0.068 | 3 | 0.778 |
TNK1 |
0.781 | -0.148 | 3 | 0.758 |
CK1A |
0.780 | -0.054 | -3 | 0.478 |
EPHA8 |
0.780 | 0.002 | -1 | 0.874 |
FLT3 |
0.780 | -0.192 | 3 | 0.774 |
NEK10_TYR |
0.780 | -0.176 | 1 | 0.639 |
DDR2 |
0.780 | -0.007 | 3 | 0.742 |
BTK |
0.779 | -0.162 | -1 | 0.824 |
LYN |
0.779 | -0.039 | 3 | 0.708 |
STLK3 |
0.779 | -0.194 | 1 | 0.730 |
FRK |
0.779 | -0.061 | -1 | 0.889 |
TAO1 |
0.778 | -0.212 | 1 | 0.698 |
PTK6 |
0.778 | -0.190 | -1 | 0.795 |
ERBB2 |
0.778 | -0.142 | 1 | 0.748 |
WEE1_TYR |
0.778 | -0.118 | -1 | 0.786 |
NTRK1 |
0.777 | -0.177 | -1 | 0.879 |
AAK1 |
0.777 | 0.074 | 1 | 0.666 |
JAK1 |
0.777 | -0.149 | 1 | 0.716 |
FLT4 |
0.776 | -0.132 | 3 | 0.759 |
PDGFRA |
0.776 | -0.252 | 3 | 0.789 |
PTK2 |
0.776 | 0.078 | -1 | 0.849 |
LTK |
0.776 | -0.173 | 3 | 0.727 |
ALK |
0.774 | -0.200 | 3 | 0.701 |
SRC |
0.773 | -0.039 | -1 | 0.860 |
NTRK2 |
0.773 | -0.205 | 3 | 0.758 |
CSK |
0.772 | -0.102 | 2 | 0.805 |
INSR |
0.772 | -0.170 | 3 | 0.726 |
EPHA2 |
0.772 | 0.016 | -1 | 0.844 |
EGFR |
0.771 | -0.069 | 1 | 0.662 |
NTRK3 |
0.771 | -0.141 | -1 | 0.830 |
MATK |
0.771 | -0.117 | -1 | 0.786 |
FGFR4 |
0.769 | -0.070 | -1 | 0.831 |
SYK |
0.768 | 0.012 | -1 | 0.835 |
YANK2 |
0.765 | -0.059 | 2 | 0.465 |
ERBB4 |
0.763 | -0.027 | 1 | 0.687 |
CK1G3 |
0.757 | -0.064 | -3 | 0.433 |
IGF1R |
0.756 | -0.173 | 3 | 0.665 |
MUSK |
0.752 | -0.202 | 1 | 0.635 |
FES |
0.750 | -0.129 | -1 | 0.754 |
ZAP70 |
0.741 | -0.056 | -1 | 0.747 |
CK1G2 |
0.740 | -0.051 | -3 | 0.527 |