Motif 126 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H7C1W4 | None | S200 | ochoa | Uncharacterized protein | None |
| O00559 | EBAG9 | S62 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14745 | NHERF1 | S162 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O15062 | ZBTB5 | S298 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15085 | ARHGEF11 | S592 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15162 | PLSCR1 | S249 | ochoa | Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b) | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:10770950, PubMed:18629440, PubMed:23590222, PubMed:23659204, PubMed:24343571, PubMed:24648509, PubMed:29748552, PubMed:32110987, PubMed:8663431, PubMed:9218461, PubMed:9485382, PubMed:9572851). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:17567603, PubMed:27206388). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions (PubMed:22789739, PubMed:23501106, PubMed:25365352, PubMed:31434743, PubMed:35138119). Also mediates the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP (PubMed:29352288, PubMed:35595813). Plays a crucial role as a defense factor against SARS-CoV-2 independently of its scramblase activity by directly targeting nascent viral vesicles to prevent virus-membrane fusion and the release of viral RNA into the host-cell cytosol (PubMed:37438530). {ECO:0000250|UniProtKB:Q9JJ00, ECO:0000269|PubMed:10770950, ECO:0000269|PubMed:15308695, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18629440, ECO:0000269|PubMed:21806988, ECO:0000269|PubMed:22789739, ECO:0000269|PubMed:23501106, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:23659204, ECO:0000269|PubMed:24343571, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:25365352, ECO:0000269|PubMed:26745724, ECO:0000269|PubMed:27206388, ECO:0000269|PubMed:29748552, ECO:0000269|PubMed:31434743, ECO:0000269|PubMed:32110987, ECO:0000269|PubMed:35138119, ECO:0000269|PubMed:37438530, ECO:0000269|PubMed:8663431, ECO:0000269|PubMed:9218461, ECO:0000269|PubMed:9485382, ECO:0000269|PubMed:9572851}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. {ECO:0000269|PubMed:21806988}. |
| O43166 | SIPA1L1 | S1393 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43526 | KCNQ2 | S511 | psp | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O75385 | ULK1 | S719 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75473 | LGR5 | S864 | psp | Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}. |
| O95279 | KCNK5 | S437 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
| O95297 | MPZL1 | S247 | ochoa | Myelin protein zero-like protein 1 (Protein zero-related) | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| O95425 | SVIL | S707 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95749 | GGPS1 | S203 | ochoa | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. {ECO:0000269|PubMed:32403198}. |
| O95757 | HSPA4L | S20 | ochoa | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| O96028 | NSD2 | S369 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P05060 | CHGB | S225 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06401 | PGR | S102 | ochoa|psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P13010 | XRCC5 | S580 | ochoa|psp | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13637 | ATP1A3 | S207 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P15144 | ANPEP | S43 | psp | Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}. |
| P16383 | GCFC2 | S96 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P18031 | PTPN1 | S393 | psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P20648 | ATP4A | S228 | ochoa | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P21359 | NF1 | S807 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P23634 | ATP2B4 | S238 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25054 | APC | S985 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P30203 | CD6 | S567 | psp | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}. |
| P48634 | PRRC2A | S19 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P50993 | ATP1A2 | S215 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P55201 | BRPF1 | S860 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| Q13315 | ATM | S1403 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q14126 | DSG2 | S1093 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14432 | PDE3A | S550 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14517 | FAT1 | S1169 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14686 | NCOA6 | S2018 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q2KJY2 | KIF26B | S270 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q53TQ3 | INO80D | S727 | ochoa | INO80 complex subunit D | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q56NI9 | ESCO2 | S312 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q58EX2 | SDK2 | S2107 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5SSJ5 | HP1BP3 | S512 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5THJ4 | VPS13D | S1603 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VST9 | OBSCN | S6831 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q68D85 | NCR3LG1 | S394 | ochoa | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}. |
| Q68D85 | NCR3LG1 | S397 | ochoa | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}. |
| Q6F5E8 | CARMIL2 | S1253 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ49 | SDE2 | S188 | ochoa | Splicing regulator SDE2 (Replication stress response regulator SDE2) | Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959). {ECO:0000269|PubMed:27906959}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250|UniProtKB:O14113, ECO:0000269|PubMed:34365507}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507). {ECO:0000269|PubMed:34365507}. |
| Q6NUQ1 | RINT1 | S19 | ochoa | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). {ECO:0000269|PubMed:11096100, ECO:0000269|PubMed:16600870, ECO:0000305}. |
| Q6P2Q9 | PRPF8 | S2060 | ochoa | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}. |
| Q6PCB6 | ABHD17C | S211 | ochoa | Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22) | Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}. |
| Q6PJF5 | RHBDF2 | S90 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6R327 | RICTOR | S1101 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6T4R5 | NHS | S1410 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UXY8 | TMC5 | S84 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6WCQ1 | MPRIP | S493 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q7L4E1 | MIGA2 | S124 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7Z2Z1 | TICRR | S1595 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3T8 | ZFYVE16 | S815 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z4V5 | HDGFL2 | S142 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q86XJ1 | GAS2L3 | S195 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IUI4 | SNX29P2 | S208 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IVL1 | NAV2 | S1121 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IZQ8 | MYOCD | S158 | ochoa | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
| Q8N3R9 | PALS1 | S130 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N960 | CEP120 | S426 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
| Q8NEG4 | FAM83F | S480 | ochoa | Protein FAM83F | None |
| Q8NEV8 | EXPH5 | S341 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NFC6 | BOD1L1 | S1989 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI08 | NCOA7 | S366 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TDJ6 | DMXL2 | S1288 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TDN4 | CABLES1 | S421 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8WUY3 | PRUNE2 | S737 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WV83 | SLC35F5 | S208 | ochoa | Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3) | Putative solute transporter. {ECO:0000305}. |
| Q8WXH0 | SYNE2 | S2784 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WXI7 | MUC16 | S5045 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WXI7 | MUC16 | S6984 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WY91 | THAP4 | S239 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q93075 | TATDN2 | S257 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96B97 | SH3KBP1 | S471 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96BY6 | DOCK10 | S1292 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96D09 | GPRASP2 | S282 | ochoa | G-protein coupled receptor-associated sorting protein 2 (GASP-2) | May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}. |
| Q96DR7 | ARHGEF26 | S296 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96L73 | NSD1 | S486 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N46 | TTC14 | S583 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96N67 | DOCK7 | S414 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NY8 | NECTIN4 | S426 | ochoa | Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}. |
| Q96P70 | IPO9 | S890 | ochoa | Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:Q91YE6, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:30855230, ECO:0000269|PubMed:34711951}. |
| Q96PV4 | PNMA5 | S133 | ochoa | Paraneoplastic antigen-like protein 5 (Tumor antigen BJ-HCC-25) | None |
| Q99567 | NUP88 | S170 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99569 | PKP4 | S1153 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99570 | PIK3R4 | S895 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99733 | NAP1L4 | S304 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q9BSJ8 | ESYT1 | S830 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BWS9 | CHID1 | S90 | ochoa | Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) | Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed:20724479}. |
| Q9BWT3 | PAPOLG | S450 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BYW2 | SETD2 | S249 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C004 | SPRY4 | S46 | ochoa | Protein sprouty homolog 4 (Spry-4) | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}. |
| Q9C0C2 | TNKS1BP1 | S1678 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0H2 | TTYH3 | S437 | ochoa | Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q6P5F7, ECO:0000269|PubMed:15010458}. |
| Q9H2Y7 | ZNF106 | S1256 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H2Y7 | ZNF106 | S1468 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H3Z4 | DNAJC5 | S177 | ochoa | DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}. |
| Q9H4A3 | WNK1 | S599 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H582 | ZNF644 | S124 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H5I5 | PIEZO2 | S2059 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H8V3 | ECT2 | S415 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NP62 | GCM1 | S47 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NPG3 | UBN1 | S660 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NYB9 | ABI2 | S368 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYP3 | DONSON | S139 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NZ09 | UBAP1 | S265 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9NZV8 | KCND2 | S552 | psp | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:35597238}. |
| Q9P0K7 | RAI14 | S386 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L2 | MARK1 | S524 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UIW2 | PLXNA1 | S1614 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UKJ3 | GPATCH8 | S653 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKL3 | CASP8AP2 | S1253 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9ULI3 | HEG1 | S426 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9ULJ3 | ZBTB21 | S202 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULK2 | ATXN7L1 | S615 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9ULV0 | MYO5B | S1106 | ochoa | Unconventional myosin-Vb | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}. |
| Q9UPV9 | TRAK1 | S719 | ochoa | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}. |
| Q9UQR1 | ZNF148 | S690 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2F5 | ICE1 | S457 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2U5 | MAP3K2 | S26 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y485 | DMXL1 | S1261 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4G2 | PLEKHM1 | S440 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y6D9 | MAD1L1 | S29 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6Q9 | NCOA3 | S836 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9BRK5 | SDF4 | S158 | Sugiyama | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| O75676 | RPS6KA4 | S507 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O94768 | STK17B | S348 | Sugiyama | Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) | Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}. |
| O95831 | AIFM1 | S519 | Sugiyama | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| Q6ZWJ1 | STXBP4 | S99 | SIGNOR | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q9H1I8 | ASCC2 | S552 | Sugiyama | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9NY33 | DPP3 | S225 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| P00813 | ADA | S291 | Sugiyama | Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697). {ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:15016824, ECO:0000269|PubMed:16670267, ECO:0000269|PubMed:20959412, ECO:0000269|PubMed:21919946, ECO:0000269|PubMed:23193172, ECO:0000269|PubMed:26038697, ECO:0000269|PubMed:26166670, ECO:0000269|PubMed:8452534, ECO:0000269|PubMed:9361033}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5578775 | Ion homeostasis | 0.002826 | 2.549 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.000530 | 3.276 |
| R-HSA-5576891 | Cardiac conduction | 0.002288 | 2.641 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.002826 | 2.549 |
| R-HSA-983712 | Ion channel transport | 0.002948 | 2.531 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.006450 | 2.190 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.007920 | 2.101 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.008964 | 2.047 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.009625 | 2.017 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 0.017849 | 1.748 |
| R-HSA-9734735 | Defective ADA disrupts (deoxy)adenosine deamination | 0.035382 | 1.451 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 0.069520 | 1.158 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.077865 | 1.109 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.094333 | 1.025 |
| R-HSA-164843 | 2-LTR circle formation | 0.110509 | 0.957 |
| R-HSA-4839744 | Signaling by APC mutants | 0.118489 | 0.926 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.118489 | 0.926 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.118489 | 0.926 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.118489 | 0.926 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.126398 | 0.898 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.134237 | 0.872 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.142006 | 0.848 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.149705 | 0.825 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.014512 | 1.838 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.157336 | 0.803 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.164899 | 0.783 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.164899 | 0.783 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.060315 | 1.220 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.179823 | 0.745 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.194482 | 0.711 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.201714 | 0.695 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.201714 | 0.695 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.201714 | 0.695 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.201714 | 0.695 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.230002 | 0.638 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.243770 | 0.613 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.270577 | 0.568 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.277130 | 0.557 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.140851 | 0.851 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.283625 | 0.547 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.283625 | 0.547 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.296440 | 0.528 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.296440 | 0.528 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.302763 | 0.519 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.315238 | 0.501 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.181816 | 0.740 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.339528 | 0.469 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.345466 | 0.462 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.191513 | 0.718 |
| R-HSA-9664873 | Pexophagy | 0.110509 | 0.957 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.300980 | 0.521 |
| R-HSA-72172 | mRNA Splicing | 0.327957 | 0.484 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.122716 | 0.911 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.164899 | 0.783 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.283578 | 0.547 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.147018 | 0.833 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.200573 | 0.698 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.313799 | 0.503 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.061099 | 1.214 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.075258 | 1.123 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.296440 | 0.528 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.280674 | 0.552 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.280674 | 0.552 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.302763 | 0.519 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.296440 | 0.528 |
| R-HSA-5693538 | Homology Directed Repair | 0.333528 | 0.477 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.290061 | 0.538 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.309028 | 0.510 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.250765 | 0.601 |
| R-HSA-373756 | SDK interactions | 0.017849 | 1.748 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.052603 | 1.279 |
| R-HSA-8866376 | Reelin signalling pathway | 0.061099 | 1.214 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.110509 | 0.957 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.126398 | 0.898 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.126398 | 0.898 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.142006 | 0.848 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.157336 | 0.803 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.164899 | 0.783 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.053280 | 1.273 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.179823 | 0.745 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.131710 | 0.880 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.270577 | 0.568 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.283625 | 0.547 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.309028 | 0.510 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.327492 | 0.485 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.202871 | 0.693 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.134237 | 0.872 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.082901 | 1.081 |
| R-HSA-373755 | Semaphorin interactions | 0.134742 | 0.870 |
| R-HSA-182971 | EGFR downregulation | 0.283625 | 0.547 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.110509 | 0.957 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.149705 | 0.825 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.302763 | 0.519 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.333537 | 0.477 |
| R-HSA-73942 | DNA Damage Reversal | 0.157336 | 0.803 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.162668 | 0.789 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.094333 | 1.025 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.126398 | 0.898 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.126398 | 0.898 |
| R-HSA-420029 | Tight junction interactions | 0.243770 | 0.613 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.270577 | 0.568 |
| R-HSA-69541 | Stabilization of p53 | 0.339528 | 0.469 |
| R-HSA-1632852 | Macroautophagy | 0.171320 | 0.766 |
| R-HSA-1500620 | Meiosis | 0.204546 | 0.689 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.110509 | 0.957 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.201714 | 0.695 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.257294 | 0.590 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.296440 | 0.528 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.309028 | 0.510 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.315238 | 0.501 |
| R-HSA-9612973 | Autophagy | 0.073259 | 1.135 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.250765 | 0.601 |
| R-HSA-73894 | DNA Repair | 0.258557 | 0.587 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.021730 | 1.663 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.134237 | 0.872 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.157336 | 0.803 |
| R-HSA-429947 | Deadenylation of mRNA | 0.236917 | 0.625 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.257294 | 0.590 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.169010 | 0.772 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.345466 | 0.462 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.345466 | 0.462 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.293950 | 0.532 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.012920 | 1.889 |
| R-HSA-9663891 | Selective autophagy | 0.217674 | 0.662 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.118489 | 0.926 |
| R-HSA-162592 | Integration of provirus | 0.126398 | 0.898 |
| R-HSA-3371556 | Cellular response to heat stress | 0.123189 | 0.909 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.142006 | 0.848 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.157336 | 0.803 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.223024 | 0.652 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.277130 | 0.557 |
| R-HSA-9930044 | Nuclear RNA decay | 0.296440 | 0.528 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.302763 | 0.519 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.309028 | 0.510 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.333537 | 0.477 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.043357 | 1.363 |
| R-HSA-201451 | Signaling by BMP | 0.257294 | 0.590 |
| R-HSA-77387 | Insulin receptor recycling | 0.263965 | 0.578 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.321393 | 0.493 |
| R-HSA-8875878 | MET promotes cell motility | 0.333537 | 0.477 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.339528 | 0.469 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.215984 | 0.666 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.243770 | 0.613 |
| R-HSA-397014 | Muscle contraction | 0.019136 | 1.718 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.179823 | 0.745 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.327492 | 0.485 |
| R-HSA-8939211 | ESR-mediated signaling | 0.083809 | 1.077 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.057936 | 1.237 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.052441 | 1.280 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.061099 | 1.214 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.215984 | 0.666 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.270577 | 0.568 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.216791 | 0.664 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.026853 | 1.571 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.099146 | 1.004 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.065172 | 1.186 |
| R-HSA-416700 | Other semaphorin interactions | 0.157336 | 0.803 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.257294 | 0.590 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.277130 | 0.557 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.230002 | 0.638 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.094333 | 1.025 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.055591 | 1.255 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.339528 | 0.469 |
| R-HSA-6806834 | Signaling by MET | 0.045865 | 1.339 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.044602 | 1.351 |
| R-HSA-9648002 | RAS processing | 0.339528 | 0.469 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.250562 | 0.601 |
| R-HSA-5205647 | Mitophagy | 0.309028 | 0.510 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.187185 | 0.728 |
| R-HSA-9755088 | Ribavirin ADME | 0.215984 | 0.666 |
| R-HSA-74217 | Purine salvage | 0.333537 | 0.477 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.196889 | 0.706 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.263652 | 0.579 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.034185 | 1.466 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.208881 | 0.680 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.243770 | 0.613 |
| R-HSA-162587 | HIV Life Cycle | 0.209805 | 0.678 |
| R-HSA-9733709 | Cardiogenesis | 0.048767 | 1.312 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.223024 | 0.652 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.327492 | 0.485 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.274446 | 0.562 |
| R-HSA-1640170 | Cell Cycle | 0.335140 | 0.475 |
| R-HSA-4839726 | Chromatin organization | 0.224901 | 0.648 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.309028 | 0.510 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.293950 | 0.532 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.164899 | 0.783 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.067648 | 1.170 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.234183 | 0.630 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.230002 | 0.638 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.309028 | 0.510 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.066261 | 1.179 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.046565 | 1.332 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.194482 | 0.711 |
| R-HSA-1296071 | Potassium Channels | 0.250765 | 0.601 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.215984 | 0.666 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.315238 | 0.501 |
| R-HSA-162582 | Signal Transduction | 0.325947 | 0.487 |
| R-HSA-354192 | Integrin signaling | 0.296440 | 0.528 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.257294 | 0.590 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.277351 | 0.557 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.169010 | 0.772 |
| R-HSA-373760 | L1CAM interactions | 0.326968 | 0.485 |
| R-HSA-75153 | Apoptotic execution phase | 0.085803 | 1.066 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.187185 | 0.728 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.313799 | 0.503 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.223024 | 0.652 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.296440 | 0.528 |
| R-HSA-9679506 | SARS-CoV Infections | 0.263303 | 0.580 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.213584 | 0.670 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.227569 | 0.643 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.323681 | 0.490 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.211099 | 0.676 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.017998 | 1.745 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.230874 | 0.637 |
| R-HSA-73887 | Death Receptor Signaling | 0.020299 | 1.693 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.351351 | 0.454 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.351351 | 0.454 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.351351 | 0.454 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.353095 | 0.452 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.359574 | 0.444 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.359574 | 0.444 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.359574 | 0.444 |
| R-HSA-194138 | Signaling by VEGF | 0.359574 | 0.444 |
| R-HSA-69481 | G2/M Checkpoints | 0.366031 | 0.436 |
| R-HSA-8854214 | TBC/RABGAPs | 0.368691 | 0.433 |
| R-HSA-1474165 | Reproduction | 0.378868 | 0.422 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.379995 | 0.420 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.379995 | 0.420 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.379995 | 0.420 |
| R-HSA-9843745 | Adipogenesis | 0.382060 | 0.418 |
| R-HSA-162906 | HIV Infection | 0.384207 | 0.415 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.385246 | 0.414 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.385571 | 0.414 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.385571 | 0.414 |
| R-HSA-9675135 | Diseases of DNA repair | 0.385571 | 0.414 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.385571 | 0.414 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.386635 | 0.413 |
| R-HSA-437239 | Recycling pathway of L1 | 0.391097 | 0.408 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.396575 | 0.402 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.402003 | 0.396 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.402003 | 0.396 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.407382 | 0.390 |
| R-HSA-109704 | PI3K Cascade | 0.407382 | 0.390 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.410470 | 0.387 |
| R-HSA-912446 | Meiotic recombination | 0.412714 | 0.384 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.417998 | 0.379 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.422894 | 0.374 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.422894 | 0.374 |
| R-HSA-1221632 | Meiotic synapsis | 0.423235 | 0.373 |
| R-HSA-177929 | Signaling by EGFR | 0.438666 | 0.358 |
| R-HSA-75893 | TNF signaling | 0.438666 | 0.358 |
| R-HSA-69242 | S Phase | 0.441276 | 0.355 |
| R-HSA-421270 | Cell-cell junction organization | 0.441733 | 0.355 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.443718 | 0.353 |
| R-HSA-112399 | IRS-mediated signalling | 0.443718 | 0.353 |
| R-HSA-5621480 | Dectin-2 family | 0.443718 | 0.353 |
| R-HSA-1483166 | Synthesis of PA | 0.443718 | 0.353 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.443718 | 0.353 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.448724 | 0.348 |
| R-HSA-191859 | snRNP Assembly | 0.453687 | 0.343 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.453687 | 0.343 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.453687 | 0.343 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.458145 | 0.339 |
| R-HSA-983189 | Kinesins | 0.458604 | 0.339 |
| R-HSA-1989781 | PPARA activates gene expression | 0.462313 | 0.335 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.463478 | 0.334 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.463478 | 0.334 |
| R-HSA-8956321 | Nucleotide salvage | 0.463478 | 0.334 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.463478 | 0.334 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.468239 | 0.330 |
| R-HSA-9610379 | HCMV Late Events | 0.468239 | 0.330 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.468308 | 0.329 |
| R-HSA-9707616 | Heme signaling | 0.468308 | 0.329 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.469745 | 0.328 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.473095 | 0.325 |
| R-HSA-8848021 | Signaling by PTK6 | 0.473095 | 0.325 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.473095 | 0.325 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.477839 | 0.321 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.477839 | 0.321 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.481480 | 0.317 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.482541 | 0.316 |
| R-HSA-109581 | Apoptosis | 0.482885 | 0.316 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.491819 | 0.308 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.496396 | 0.304 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.496396 | 0.304 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.496396 | 0.304 |
| R-HSA-446728 | Cell junction organization | 0.503859 | 0.298 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.505427 | 0.296 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.505427 | 0.296 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.505427 | 0.296 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.509882 | 0.293 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.514297 | 0.289 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.514297 | 0.289 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.518673 | 0.285 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.522550 | 0.282 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.527307 | 0.278 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.527307 | 0.278 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.531079 | 0.275 |
| R-HSA-5689603 | UCH proteinases | 0.531566 | 0.274 |
| R-HSA-2559583 | Cellular Senescence | 0.536220 | 0.271 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.539971 | 0.268 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.544117 | 0.264 |
| R-HSA-9659379 | Sensory processing of sound | 0.544117 | 0.264 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.544293 | 0.264 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.548225 | 0.261 |
| R-HSA-382551 | Transport of small molecules | 0.551650 | 0.258 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.552297 | 0.258 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.556333 | 0.255 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.560333 | 0.252 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.564296 | 0.248 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.568224 | 0.245 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.568224 | 0.245 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.572117 | 0.243 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.572117 | 0.243 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.572117 | 0.243 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.575975 | 0.240 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.575975 | 0.240 |
| R-HSA-422475 | Axon guidance | 0.579665 | 0.237 |
| R-HSA-1500931 | Cell-Cell communication | 0.584907 | 0.233 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.588187 | 0.230 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.591066 | 0.228 |
| R-HSA-109582 | Hemostasis | 0.591248 | 0.228 |
| R-HSA-2262752 | Cellular responses to stress | 0.595931 | 0.225 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.598903 | 0.223 |
| R-HSA-8957322 | Metabolism of steroids | 0.600877 | 0.221 |
| R-HSA-5357801 | Programmed Cell Death | 0.602920 | 0.220 |
| R-HSA-6805567 | Keratinization | 0.605336 | 0.218 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.605622 | 0.218 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.612064 | 0.213 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.612706 | 0.213 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.626498 | 0.203 |
| R-HSA-3214847 | HATs acetylate histones | 0.629869 | 0.201 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.633209 | 0.198 |
| R-HSA-70171 | Glycolysis | 0.633209 | 0.198 |
| R-HSA-9675108 | Nervous system development | 0.635769 | 0.197 |
| R-HSA-1483255 | PI Metabolism | 0.639801 | 0.194 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.644525 | 0.191 |
| R-HSA-112316 | Neuronal System | 0.644884 | 0.191 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.646275 | 0.190 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.648159 | 0.188 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.652634 | 0.185 |
| R-HSA-418346 | Platelet homeostasis | 0.655771 | 0.183 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.655771 | 0.183 |
| R-HSA-211000 | Gene Silencing by RNA | 0.658879 | 0.181 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.665013 | 0.177 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.674008 | 0.171 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.682764 | 0.166 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.685630 | 0.164 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.688471 | 0.162 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.694076 | 0.159 |
| R-HSA-70326 | Glucose metabolism | 0.694076 | 0.159 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.694076 | 0.159 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.694076 | 0.159 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.696841 | 0.157 |
| R-HSA-9609646 | HCMV Infection | 0.700880 | 0.154 |
| R-HSA-68875 | Mitotic Prophase | 0.702296 | 0.153 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.704987 | 0.152 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.710297 | 0.149 |
| R-HSA-5688426 | Deubiquitination | 0.710437 | 0.148 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.712916 | 0.147 |
| R-HSA-9824446 | Viral Infection Pathways | 0.712929 | 0.147 |
| R-HSA-69206 | G1/S Transition | 0.718084 | 0.144 |
| R-HSA-114608 | Platelet degranulation | 0.723160 | 0.141 |
| R-HSA-199991 | Membrane Trafficking | 0.723848 | 0.140 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.734103 | 0.134 |
| R-HSA-9909396 | Circadian clock | 0.737849 | 0.132 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.740220 | 0.131 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.744464 | 0.128 |
| R-HSA-5173105 | O-linked glycosylation | 0.751763 | 0.124 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.754010 | 0.123 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.756117 | 0.121 |
| R-HSA-9658195 | Leishmania infection | 0.756117 | 0.121 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.758443 | 0.120 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.758443 | 0.120 |
| R-HSA-9664407 | Parasite infection | 0.758443 | 0.120 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.760629 | 0.119 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.767072 | 0.115 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.768875 | 0.114 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.773342 | 0.112 |
| R-HSA-1483257 | Phospholipid metabolism | 0.778061 | 0.109 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.779561 | 0.108 |
| R-HSA-195721 | Signaling by WNT | 0.782534 | 0.106 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.783423 | 0.106 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.785385 | 0.105 |
| R-HSA-8953854 | Metabolism of RNA | 0.788025 | 0.103 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.789256 | 0.103 |
| R-HSA-1266738 | Developmental Biology | 0.789938 | 0.102 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.791165 | 0.102 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.796791 | 0.099 |
| R-HSA-877300 | Interferon gamma signaling | 0.798633 | 0.098 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.800458 | 0.097 |
| R-HSA-74160 | Gene expression (Transcription) | 0.803750 | 0.095 |
| R-HSA-6798695 | Neutrophil degranulation | 0.807495 | 0.093 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.807596 | 0.093 |
| R-HSA-5619102 | SLC transporter disorders | 0.812782 | 0.090 |
| R-HSA-72306 | tRNA processing | 0.819482 | 0.086 |
| R-HSA-418555 | G alpha (s) signalling events | 0.821119 | 0.086 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.821119 | 0.086 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.824350 | 0.084 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.824350 | 0.084 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.825943 | 0.083 |
| R-HSA-168255 | Influenza Infection | 0.833698 | 0.079 |
| R-HSA-3781865 | Diseases of glycosylation | 0.841109 | 0.075 |
| R-HSA-69275 | G2/M Transition | 0.843981 | 0.074 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.846802 | 0.072 |
| R-HSA-388396 | GPCR downstream signalling | 0.847742 | 0.072 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.850938 | 0.070 |
| R-HSA-68877 | Mitotic Prometaphase | 0.853633 | 0.069 |
| R-HSA-9609690 | HCMV Early Events | 0.857586 | 0.067 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.866401 | 0.062 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.872055 | 0.059 |
| R-HSA-68886 | M Phase | 0.880302 | 0.055 |
| R-HSA-913531 | Interferon Signaling | 0.881164 | 0.055 |
| R-HSA-68882 | Mitotic Anaphase | 0.882439 | 0.054 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.883508 | 0.054 |
| R-HSA-418990 | Adherens junctions interactions | 0.884568 | 0.053 |
| R-HSA-9748784 | Drug ADME | 0.884568 | 0.053 |
| R-HSA-8951664 | Neddylation | 0.887690 | 0.052 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.895612 | 0.048 |
| R-HSA-372790 | Signaling by GPCR | 0.901316 | 0.045 |
| R-HSA-15869 | Metabolism of nucleotides | 0.902087 | 0.045 |
| R-HSA-212436 | Generic Transcription Pathway | 0.909650 | 0.041 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.911466 | 0.040 |
| R-HSA-5663205 | Infectious disease | 0.912810 | 0.040 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.913904 | 0.039 |
| R-HSA-5668914 | Diseases of metabolism | 0.913906 | 0.039 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.918471 | 0.037 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.942991 | 0.025 |
| R-HSA-1643685 | Disease | 0.945884 | 0.024 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.954694 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.955928 | 0.020 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.963000 | 0.016 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.974884 | 0.011 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.976457 | 0.010 |
| R-HSA-72766 | Translation | 0.983588 | 0.007 |
| R-HSA-168249 | Innate Immune System | 0.984935 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.987103 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 0.987202 | 0.006 |
| R-HSA-1280218 | Adaptive Immune System | 0.988360 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 0.994536 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.999178 | 0.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.999574 | 0.000 |
| R-HSA-168256 | Immune System | 0.999793 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999992 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
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| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.848 | 0.168 | 2 | 0.828 |
IKKB |
0.840 | 0.166 | -2 | 0.774 |
TBK1 |
0.837 | 0.193 | 1 | 0.822 |
IKKE |
0.836 | 0.205 | 1 | 0.823 |
IKKA |
0.835 | 0.177 | -2 | 0.777 |
DSTYK |
0.834 | 0.119 | 2 | 0.837 |
CAMK2G |
0.833 | 0.171 | 2 | 0.837 |
GRK1 |
0.830 | 0.197 | -2 | 0.810 |
RAF1 |
0.829 | 0.098 | 1 | 0.831 |
NDR2 |
0.829 | 0.045 | -3 | 0.798 |
PRPK |
0.828 | -0.004 | -1 | 0.846 |
GCN2 |
0.828 | -0.071 | 2 | 0.775 |
MOS |
0.827 | 0.053 | 1 | 0.712 |
PIM3 |
0.825 | 0.038 | -3 | 0.790 |
MTOR |
0.825 | -0.001 | 1 | 0.759 |
CLK3 |
0.825 | 0.077 | 1 | 0.669 |
CDC7 |
0.825 | -0.047 | 1 | 0.686 |
FAM20C |
0.824 | 0.116 | 2 | 0.615 |
TGFBR1 |
0.824 | 0.242 | -2 | 0.910 |
GRK6 |
0.823 | 0.211 | 1 | 0.733 |
NEK6 |
0.823 | 0.020 | -2 | 0.917 |
TGFBR2 |
0.823 | 0.077 | -2 | 0.895 |
LATS2 |
0.823 | 0.081 | -5 | 0.766 |
BMPR2 |
0.822 | 0.031 | -2 | 0.921 |
PDHK4 |
0.822 | -0.058 | 1 | 0.809 |
PDHK1 |
0.821 | 0.047 | 1 | 0.824 |
CAMK2B |
0.821 | 0.164 | 2 | 0.837 |
BMPR1B |
0.821 | 0.203 | 1 | 0.642 |
NEK7 |
0.821 | -0.027 | -3 | 0.803 |
GRK7 |
0.819 | 0.238 | 1 | 0.690 |
PLK3 |
0.819 | 0.179 | 2 | 0.770 |
ULK2 |
0.818 | -0.108 | 2 | 0.729 |
PLK1 |
0.818 | 0.156 | -2 | 0.890 |
ALK4 |
0.818 | 0.200 | -2 | 0.928 |
BCKDK |
0.818 | 0.046 | -1 | 0.772 |
GRK4 |
0.817 | 0.055 | -2 | 0.869 |
CAMK2D |
0.817 | 0.065 | -3 | 0.789 |
ALK2 |
0.816 | 0.239 | -2 | 0.913 |
ATM |
0.816 | 0.053 | 1 | 0.678 |
MST4 |
0.816 | 0.018 | 2 | 0.806 |
HUNK |
0.816 | -0.050 | 2 | 0.773 |
PRKD1 |
0.815 | 0.001 | -3 | 0.773 |
CAMK1B |
0.815 | -0.054 | -3 | 0.814 |
GRK5 |
0.815 | 0.014 | -3 | 0.843 |
DNAPK |
0.814 | 0.152 | 1 | 0.732 |
NDR1 |
0.814 | -0.039 | -3 | 0.787 |
MLK1 |
0.814 | -0.066 | 2 | 0.747 |
MAPKAPK2 |
0.814 | 0.066 | -3 | 0.678 |
ATR |
0.814 | -0.041 | 1 | 0.730 |
PKN3 |
0.814 | -0.020 | -3 | 0.773 |
CAMK2A |
0.813 | 0.118 | 2 | 0.855 |
KIS |
0.812 | -0.009 | 1 | 0.582 |
RIPK3 |
0.812 | -0.110 | 3 | 0.606 |
SKMLCK |
0.812 | -0.026 | -2 | 0.839 |
NLK |
0.812 | -0.093 | 1 | 0.735 |
CK2A2 |
0.811 | 0.340 | 1 | 0.523 |
ERK5 |
0.811 | -0.050 | 1 | 0.708 |
CDKL1 |
0.811 | -0.035 | -3 | 0.750 |
ACVR2A |
0.811 | 0.153 | -2 | 0.881 |
ULK1 |
0.810 | -0.111 | -3 | 0.774 |
PIM1 |
0.810 | 0.032 | -3 | 0.735 |
ACVR2B |
0.810 | 0.143 | -2 | 0.893 |
LATS1 |
0.809 | 0.104 | -3 | 0.814 |
MARK4 |
0.809 | -0.053 | 4 | 0.798 |
WNK1 |
0.809 | -0.057 | -2 | 0.853 |
CHAK2 |
0.808 | -0.070 | -1 | 0.825 |
RSK2 |
0.808 | -0.004 | -3 | 0.721 |
DLK |
0.808 | -0.038 | 1 | 0.761 |
BMPR1A |
0.808 | 0.190 | 1 | 0.613 |
MASTL |
0.808 | -0.161 | -2 | 0.851 |
AMPKA1 |
0.808 | -0.051 | -3 | 0.805 |
MAPKAPK3 |
0.808 | -0.011 | -3 | 0.724 |
NUAK2 |
0.807 | -0.061 | -3 | 0.789 |
NIK |
0.807 | -0.114 | -3 | 0.836 |
ANKRD3 |
0.807 | -0.053 | 1 | 0.805 |
YSK4 |
0.807 | 0.058 | 1 | 0.796 |
SRPK1 |
0.806 | -0.013 | -3 | 0.696 |
TTBK2 |
0.805 | -0.045 | 2 | 0.640 |
CAMLCK |
0.805 | -0.078 | -2 | 0.833 |
WNK3 |
0.805 | -0.151 | 1 | 0.789 |
PRKD2 |
0.805 | -0.020 | -3 | 0.713 |
NEK9 |
0.805 | -0.119 | 2 | 0.769 |
PKN2 |
0.804 | -0.065 | -3 | 0.787 |
P90RSK |
0.804 | -0.040 | -3 | 0.720 |
TLK2 |
0.804 | 0.084 | 1 | 0.741 |
PKCD |
0.803 | -0.036 | 2 | 0.725 |
CDKL5 |
0.802 | -0.045 | -3 | 0.741 |
DAPK2 |
0.802 | -0.111 | -3 | 0.819 |
MLK2 |
0.802 | -0.139 | 2 | 0.769 |
TSSK2 |
0.802 | -0.043 | -5 | 0.823 |
MLK3 |
0.802 | -0.060 | 2 | 0.675 |
ICK |
0.801 | -0.040 | -3 | 0.786 |
PLK4 |
0.801 | 0.007 | 2 | 0.596 |
PKACG |
0.801 | -0.038 | -2 | 0.699 |
AMPKA2 |
0.801 | -0.058 | -3 | 0.770 |
MEK1 |
0.800 | -0.038 | 2 | 0.825 |
TLK1 |
0.800 | 0.090 | -2 | 0.900 |
HIPK4 |
0.800 | -0.070 | 1 | 0.649 |
MSK2 |
0.800 | -0.034 | -3 | 0.690 |
RSK3 |
0.799 | -0.067 | -3 | 0.712 |
CK2A1 |
0.799 | 0.296 | 1 | 0.505 |
TSSK1 |
0.799 | -0.051 | -3 | 0.825 |
P70S6KB |
0.798 | -0.061 | -3 | 0.744 |
CDK8 |
0.797 | -0.059 | 1 | 0.552 |
PLK2 |
0.797 | 0.134 | -3 | 0.790 |
MLK4 |
0.797 | -0.066 | 2 | 0.661 |
CHK1 |
0.797 | -0.013 | -3 | 0.786 |
RIPK1 |
0.796 | -0.215 | 1 | 0.752 |
PAK1 |
0.796 | -0.049 | -2 | 0.746 |
SRPK2 |
0.796 | -0.018 | -3 | 0.621 |
MSK1 |
0.796 | 0.001 | -3 | 0.694 |
JNK2 |
0.796 | 0.014 | 1 | 0.533 |
PKR |
0.796 | -0.066 | 1 | 0.745 |
NIM1 |
0.796 | -0.135 | 3 | 0.628 |
RSK4 |
0.795 | 0.008 | -3 | 0.691 |
CAMK4 |
0.795 | -0.110 | -3 | 0.773 |
MEKK3 |
0.795 | 0.003 | 1 | 0.782 |
JNK3 |
0.795 | 0.003 | 1 | 0.551 |
SRPK3 |
0.795 | -0.024 | -3 | 0.670 |
NEK2 |
0.794 | -0.059 | 2 | 0.731 |
AURA |
0.793 | 0.007 | -2 | 0.578 |
NUAK1 |
0.793 | -0.084 | -3 | 0.738 |
BRAF |
0.793 | -0.004 | -4 | 0.776 |
BRSK1 |
0.793 | -0.062 | -3 | 0.738 |
GRK2 |
0.793 | -0.012 | -2 | 0.753 |
CDK1 |
0.793 | -0.029 | 1 | 0.508 |
AURC |
0.793 | -0.029 | -2 | 0.595 |
PAK3 |
0.792 | -0.101 | -2 | 0.748 |
HRI |
0.791 | -0.091 | -2 | 0.904 |
MNK2 |
0.791 | -0.070 | -2 | 0.754 |
QSK |
0.791 | -0.076 | 4 | 0.782 |
MARK3 |
0.790 | -0.047 | 4 | 0.744 |
CLK2 |
0.790 | 0.030 | -3 | 0.699 |
PKACB |
0.790 | -0.002 | -2 | 0.618 |
VRK2 |
0.790 | -0.263 | 1 | 0.767 |
IRE1 |
0.790 | -0.187 | 1 | 0.700 |
PERK |
0.790 | -0.074 | -2 | 0.900 |
MARK2 |
0.789 | -0.055 | 4 | 0.711 |
CDK19 |
0.789 | -0.067 | 1 | 0.520 |
IRE2 |
0.789 | -0.145 | 2 | 0.657 |
ZAK |
0.789 | -0.071 | 1 | 0.745 |
MEKK1 |
0.789 | -0.091 | 1 | 0.778 |
PHKG1 |
0.789 | -0.103 | -3 | 0.776 |
SMG1 |
0.789 | -0.078 | 1 | 0.694 |
DRAK1 |
0.788 | -0.081 | 1 | 0.685 |
PKCG |
0.788 | -0.081 | 2 | 0.660 |
PKCA |
0.788 | -0.067 | 2 | 0.649 |
DYRK2 |
0.788 | -0.059 | 1 | 0.567 |
BRSK2 |
0.788 | -0.110 | -3 | 0.764 |
PAK6 |
0.788 | -0.021 | -2 | 0.663 |
CK1E |
0.788 | 0.042 | -3 | 0.605 |
P38A |
0.788 | -0.039 | 1 | 0.608 |
CLK4 |
0.788 | -0.033 | -3 | 0.715 |
AURB |
0.788 | -0.036 | -2 | 0.600 |
PAK2 |
0.787 | -0.087 | -2 | 0.739 |
P38B |
0.787 | -0.016 | 1 | 0.539 |
MEKK2 |
0.787 | -0.049 | 2 | 0.752 |
MYLK4 |
0.787 | -0.065 | -2 | 0.732 |
QIK |
0.787 | -0.159 | -3 | 0.784 |
PRKD3 |
0.787 | -0.079 | -3 | 0.687 |
CDK7 |
0.786 | -0.090 | 1 | 0.560 |
PRKX |
0.786 | 0.021 | -3 | 0.628 |
PASK |
0.786 | 0.007 | -3 | 0.808 |
PKCB |
0.786 | -0.095 | 2 | 0.660 |
MELK |
0.786 | -0.143 | -3 | 0.753 |
CDK5 |
0.786 | -0.062 | 1 | 0.571 |
CHAK1 |
0.785 | -0.171 | 2 | 0.704 |
DCAMKL1 |
0.785 | -0.053 | -3 | 0.732 |
GRK3 |
0.785 | 0.022 | -2 | 0.716 |
CDK13 |
0.785 | -0.085 | 1 | 0.544 |
SGK3 |
0.785 | -0.031 | -3 | 0.708 |
SIK |
0.785 | -0.098 | -3 | 0.708 |
MARK1 |
0.785 | -0.073 | 4 | 0.770 |
TAO3 |
0.784 | -0.016 | 1 | 0.778 |
ERK1 |
0.784 | -0.042 | 1 | 0.544 |
P38G |
0.784 | -0.029 | 1 | 0.444 |
MST3 |
0.784 | -0.026 | 2 | 0.766 |
NEK5 |
0.783 | -0.101 | 1 | 0.785 |
CK1G1 |
0.783 | 0.047 | -3 | 0.594 |
MEK5 |
0.783 | -0.188 | 2 | 0.783 |
CLK1 |
0.783 | -0.038 | -3 | 0.689 |
MST2 |
0.783 | 0.073 | 1 | 0.821 |
GAK |
0.783 | 0.068 | 1 | 0.767 |
MNK1 |
0.783 | -0.088 | -2 | 0.764 |
GCK |
0.782 | 0.107 | 1 | 0.831 |
PKCH |
0.782 | -0.114 | 2 | 0.640 |
PIM2 |
0.782 | -0.041 | -3 | 0.692 |
CK1D |
0.781 | 0.055 | -3 | 0.557 |
ERK2 |
0.781 | -0.072 | 1 | 0.580 |
WNK4 |
0.781 | -0.122 | -2 | 0.865 |
TTBK1 |
0.781 | -0.076 | 2 | 0.565 |
MAPKAPK5 |
0.781 | -0.129 | -3 | 0.663 |
CDK2 |
0.781 | -0.093 | 1 | 0.588 |
PKCZ |
0.780 | -0.146 | 2 | 0.694 |
PKG2 |
0.780 | -0.064 | -2 | 0.610 |
CDK3 |
0.780 | -0.027 | 1 | 0.457 |
AKT2 |
0.780 | -0.044 | -3 | 0.633 |
DCAMKL2 |
0.779 | -0.066 | -3 | 0.756 |
NEK11 |
0.779 | -0.060 | 1 | 0.796 |
CDK18 |
0.779 | -0.071 | 1 | 0.496 |
DYRK4 |
0.779 | -0.027 | 1 | 0.498 |
SNRK |
0.778 | -0.215 | 2 | 0.617 |
TAK1 |
0.778 | 0.071 | 1 | 0.809 |
MINK |
0.778 | 0.074 | 1 | 0.836 |
HIPK2 |
0.777 | -0.041 | 1 | 0.489 |
MPSK1 |
0.777 | -0.040 | 1 | 0.708 |
CAMKK1 |
0.776 | -0.100 | -2 | 0.761 |
CAMK1G |
0.776 | -0.115 | -3 | 0.705 |
PRP4 |
0.776 | -0.080 | -3 | 0.705 |
CDK12 |
0.776 | -0.090 | 1 | 0.525 |
CK1A2 |
0.776 | 0.039 | -3 | 0.556 |
TNIK |
0.776 | 0.048 | 3 | 0.668 |
MST1 |
0.775 | 0.062 | 1 | 0.816 |
CDK17 |
0.775 | -0.077 | 1 | 0.443 |
HIPK1 |
0.775 | -0.067 | 1 | 0.589 |
CDK9 |
0.774 | -0.111 | 1 | 0.558 |
DYRK1A |
0.774 | -0.070 | 1 | 0.623 |
IRAK4 |
0.774 | -0.192 | 1 | 0.735 |
PHKG2 |
0.774 | -0.097 | -3 | 0.744 |
PKACA |
0.774 | -0.021 | -2 | 0.551 |
SMMLCK |
0.774 | -0.096 | -3 | 0.764 |
HPK1 |
0.773 | 0.079 | 1 | 0.844 |
JNK1 |
0.773 | -0.020 | 1 | 0.499 |
NEK4 |
0.773 | -0.055 | 1 | 0.810 |
P38D |
0.773 | -0.025 | 1 | 0.461 |
CAMK1D |
0.773 | -0.052 | -3 | 0.634 |
NEK8 |
0.773 | -0.153 | 2 | 0.736 |
KHS1 |
0.772 | 0.112 | 1 | 0.848 |
GSK3A |
0.772 | -0.024 | 4 | 0.377 |
LKB1 |
0.772 | -0.102 | -3 | 0.789 |
TAO2 |
0.772 | -0.102 | 2 | 0.779 |
IRAK1 |
0.772 | -0.219 | -1 | 0.716 |
HGK |
0.772 | -0.011 | 3 | 0.663 |
EEF2K |
0.771 | -0.045 | 3 | 0.669 |
PINK1 |
0.771 | -0.229 | 1 | 0.699 |
AKT1 |
0.770 | -0.045 | -3 | 0.651 |
GSK3B |
0.770 | -0.065 | 4 | 0.363 |
HIPK3 |
0.770 | -0.099 | 1 | 0.632 |
P70S6K |
0.770 | -0.085 | -3 | 0.652 |
PKCT |
0.770 | -0.119 | 2 | 0.652 |
CAMKK2 |
0.770 | -0.108 | -2 | 0.746 |
SSTK |
0.770 | -0.103 | 4 | 0.769 |
PDK1 |
0.770 | -0.089 | 1 | 0.773 |
DYRK1B |
0.770 | -0.065 | 1 | 0.535 |
KHS2 |
0.769 | 0.097 | 1 | 0.853 |
PAK5 |
0.769 | -0.062 | -2 | 0.605 |
MAP3K15 |
0.768 | -0.097 | 1 | 0.757 |
CDK16 |
0.768 | -0.058 | 1 | 0.463 |
CDK14 |
0.766 | -0.093 | 1 | 0.553 |
PAK4 |
0.766 | -0.064 | -2 | 0.608 |
NEK1 |
0.765 | -0.113 | 1 | 0.779 |
MEKK6 |
0.763 | -0.166 | 1 | 0.773 |
DAPK3 |
0.763 | -0.082 | -3 | 0.747 |
PDHK3_TYR |
0.762 | 0.221 | 4 | 0.855 |
PKCI |
0.762 | -0.137 | 2 | 0.655 |
DYRK3 |
0.761 | -0.085 | 1 | 0.587 |
MEK2 |
0.761 | -0.156 | 2 | 0.779 |
LOK |
0.761 | -0.081 | -2 | 0.757 |
RIPK2 |
0.761 | -0.194 | 1 | 0.745 |
TTK |
0.761 | 0.019 | -2 | 0.898 |
SLK |
0.760 | -0.049 | -2 | 0.715 |
PKN1 |
0.760 | -0.092 | -3 | 0.668 |
ERK7 |
0.760 | -0.095 | 2 | 0.431 |
SGK1 |
0.759 | -0.025 | -3 | 0.556 |
MRCKA |
0.759 | -0.034 | -3 | 0.701 |
CHK2 |
0.759 | -0.065 | -3 | 0.578 |
CDK10 |
0.759 | -0.087 | 1 | 0.533 |
OSR1 |
0.759 | -0.026 | 2 | 0.760 |
PKCE |
0.758 | -0.096 | 2 | 0.637 |
VRK1 |
0.758 | -0.218 | 2 | 0.759 |
YSK1 |
0.758 | -0.105 | 2 | 0.734 |
MAK |
0.758 | -0.003 | -2 | 0.726 |
LRRK2 |
0.757 | -0.215 | 2 | 0.772 |
DAPK1 |
0.757 | -0.082 | -3 | 0.728 |
ROCK2 |
0.757 | -0.038 | -3 | 0.736 |
AKT3 |
0.757 | -0.045 | -3 | 0.569 |
MRCKB |
0.756 | -0.043 | -3 | 0.681 |
MAP2K6_TYR |
0.755 | 0.139 | -1 | 0.881 |
SBK |
0.755 | -0.025 | -3 | 0.515 |
PDHK4_TYR |
0.755 | 0.157 | 2 | 0.872 |
PDHK1_TYR |
0.755 | 0.158 | -1 | 0.904 |
STK33 |
0.753 | -0.179 | 2 | 0.582 |
CAMK1A |
0.753 | -0.083 | -3 | 0.593 |
PBK |
0.753 | -0.055 | 1 | 0.718 |
CDK6 |
0.752 | -0.100 | 1 | 0.539 |
BMPR2_TYR |
0.752 | 0.099 | -1 | 0.900 |
ASK1 |
0.752 | -0.068 | 1 | 0.742 |
MAP2K4_TYR |
0.752 | 0.043 | -1 | 0.864 |
ALPHAK3 |
0.751 | -0.017 | -1 | 0.802 |
BIKE |
0.749 | 0.017 | 1 | 0.679 |
CDK4 |
0.749 | -0.102 | 1 | 0.508 |
MAP2K7_TYR |
0.749 | -0.010 | 2 | 0.829 |
DMPK1 |
0.749 | -0.034 | -3 | 0.703 |
NEK3 |
0.748 | -0.188 | 1 | 0.759 |
TESK1_TYR |
0.747 | -0.086 | 3 | 0.713 |
MOK |
0.747 | -0.064 | 1 | 0.599 |
EPHA6 |
0.745 | 0.017 | -1 | 0.896 |
MYO3A |
0.745 | -0.052 | 1 | 0.776 |
YANK3 |
0.745 | -0.057 | 2 | 0.394 |
STLK3 |
0.745 | -0.042 | 1 | 0.745 |
INSRR |
0.744 | 0.029 | 3 | 0.602 |
PKMYT1_TYR |
0.744 | -0.155 | 3 | 0.694 |
RET |
0.744 | -0.031 | 1 | 0.775 |
CK1A |
0.743 | 0.008 | -3 | 0.474 |
JAK3 |
0.742 | -0.011 | 1 | 0.738 |
TAO1 |
0.742 | -0.104 | 1 | 0.755 |
TYK2 |
0.742 | -0.058 | 1 | 0.786 |
EPHB4 |
0.742 | -0.031 | -1 | 0.857 |
CRIK |
0.742 | -0.051 | -3 | 0.649 |
PINK1_TYR |
0.741 | -0.157 | 1 | 0.750 |
LCK |
0.741 | 0.042 | -1 | 0.844 |
JAK2 |
0.741 | -0.052 | 1 | 0.780 |
PKG1 |
0.741 | -0.096 | -2 | 0.512 |
CSF1R |
0.741 | -0.049 | 3 | 0.628 |
YES1 |
0.740 | -0.022 | -1 | 0.820 |
ROCK1 |
0.740 | -0.063 | -3 | 0.698 |
MYO3B |
0.740 | -0.121 | 2 | 0.745 |
MST1R |
0.740 | -0.107 | 3 | 0.648 |
HASPIN |
0.739 | -0.102 | -1 | 0.632 |
BLK |
0.739 | 0.049 | -1 | 0.848 |
FGR |
0.739 | -0.038 | 1 | 0.778 |
TXK |
0.739 | 0.016 | 1 | 0.694 |
BUB1 |
0.739 | -0.119 | -5 | 0.748 |
HCK |
0.738 | -0.019 | -1 | 0.829 |
ROS1 |
0.738 | -0.101 | 3 | 0.613 |
ABL2 |
0.738 | -0.043 | -1 | 0.801 |
EPHA4 |
0.737 | 0.001 | 2 | 0.772 |
FYN |
0.737 | 0.078 | -1 | 0.828 |
EPHB2 |
0.736 | -0.007 | -1 | 0.845 |
NEK10_TYR |
0.736 | 0.016 | 1 | 0.736 |
SRMS |
0.736 | -0.033 | 1 | 0.742 |
FER |
0.735 | -0.081 | 1 | 0.754 |
LIMK2_TYR |
0.735 | -0.166 | -3 | 0.848 |
KIT |
0.735 | -0.043 | 3 | 0.630 |
EPHB3 |
0.734 | -0.043 | -1 | 0.843 |
EPHB1 |
0.734 | -0.056 | 1 | 0.748 |
AAK1 |
0.734 | 0.045 | 1 | 0.594 |
TYRO3 |
0.733 | -0.181 | 3 | 0.632 |
FGFR2 |
0.733 | -0.077 | 3 | 0.638 |
ITK |
0.733 | -0.064 | -1 | 0.786 |
JAK1 |
0.731 | -0.024 | 1 | 0.772 |
DDR1 |
0.730 | -0.180 | 4 | 0.762 |
FLT1 |
0.730 | 0.011 | -1 | 0.882 |
ABL1 |
0.730 | -0.092 | -1 | 0.786 |
LIMK1_TYR |
0.729 | -0.272 | 2 | 0.795 |
FGFR1 |
0.728 | -0.122 | 3 | 0.623 |
MET |
0.728 | -0.072 | 3 | 0.617 |
KDR |
0.728 | -0.089 | 3 | 0.598 |
BMX |
0.727 | -0.051 | -1 | 0.725 |
ERBB2 |
0.727 | -0.057 | 1 | 0.716 |
LYN |
0.727 | -0.033 | 3 | 0.587 |
FLT3 |
0.726 | -0.128 | 3 | 0.624 |
FGFR3 |
0.726 | -0.053 | 3 | 0.618 |
EPHA7 |
0.726 | -0.047 | 2 | 0.755 |
INSR |
0.726 | -0.091 | 3 | 0.589 |
CK1G3 |
0.726 | 0.039 | -3 | 0.425 |
EGFR |
0.725 | 0.009 | 1 | 0.625 |
MERTK |
0.725 | -0.108 | 3 | 0.621 |
TEK |
0.724 | -0.157 | 3 | 0.589 |
PDGFRB |
0.724 | -0.189 | 3 | 0.634 |
NTRK1 |
0.724 | -0.110 | -1 | 0.815 |
TNK2 |
0.724 | -0.153 | 3 | 0.607 |
EPHA5 |
0.724 | -0.016 | 2 | 0.758 |
FRK |
0.724 | -0.056 | -1 | 0.840 |
EPHA3 |
0.723 | -0.074 | 2 | 0.739 |
TEC |
0.723 | -0.093 | -1 | 0.698 |
SRC |
0.723 | -0.026 | -1 | 0.808 |
PTK2 |
0.722 | 0.060 | -1 | 0.863 |
AXL |
0.722 | -0.163 | 3 | 0.624 |
EPHA8 |
0.722 | -0.026 | -1 | 0.851 |
FGFR4 |
0.722 | -0.009 | -1 | 0.798 |
SYK |
0.721 | 0.072 | -1 | 0.857 |
FLT4 |
0.720 | -0.111 | 3 | 0.608 |
NTRK3 |
0.720 | -0.101 | -1 | 0.780 |
TNNI3K_TYR |
0.720 | -0.130 | 1 | 0.726 |
BTK |
0.719 | -0.176 | -1 | 0.725 |
ALK |
0.719 | -0.150 | 3 | 0.575 |
NTRK2 |
0.719 | -0.159 | 3 | 0.613 |
LTK |
0.718 | -0.143 | 3 | 0.597 |
TNK1 |
0.717 | -0.189 | 3 | 0.616 |
EPHA1 |
0.717 | -0.133 | 3 | 0.599 |
EPHA2 |
0.717 | -0.011 | -1 | 0.831 |
PDGFRA |
0.716 | -0.230 | 3 | 0.630 |
CSK |
0.716 | -0.080 | 2 | 0.758 |
PTK6 |
0.716 | -0.166 | -1 | 0.706 |
IGF1R |
0.715 | -0.059 | 3 | 0.546 |
DDR2 |
0.714 | -0.107 | 3 | 0.593 |
YANK2 |
0.714 | -0.072 | 2 | 0.411 |
MATK |
0.713 | -0.100 | -1 | 0.747 |
ERBB4 |
0.712 | -0.006 | 1 | 0.619 |
WEE1_TYR |
0.712 | -0.150 | -1 | 0.730 |
PTK2B |
0.712 | -0.125 | -1 | 0.741 |
CK1G2 |
0.711 | 0.014 | -3 | 0.515 |
MUSK |
0.699 | -0.162 | 1 | 0.639 |
ZAP70 |
0.698 | -0.008 | -1 | 0.770 |
FES |
0.690 | -0.140 | -1 | 0.700 |