Motif 1252 (n=45)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00194 | RAB27B | S83 | ochoa | Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG) | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). {ECO:0000250|UniProtKB:Q8HZJ5, ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:30771381}. |
| O14966 | RAB29 | S72 | psp | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}. |
| O60814 | H2BC12 | T89 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O95716 | RAB3D | T86 | ochoa | Ras-related protein Rab-3D (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (By similarity). {ECO:0000250|UniProtKB:P20336, ECO:0000250|UniProtKB:P35276}. |
| P0CG47 | UBB | T55 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T55 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P10114 | RAP2A | S66 | ochoa | Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:35293963}. |
| P20336 | RAB3A | T86 | ochoa | Ras-related protein Rab-3A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:2501306). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:2501306). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:2501306). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). {ECO:0000250|UniProtKB:P63011, ECO:0000250|UniProtKB:P63012, ECO:0000269|PubMed:22248876, ECO:0000269|PubMed:2501306, ECO:0000269|PubMed:27325790, ECO:0000269|PubMed:30599141}. |
| P20337 | RAB3B | T86 | ochoa | Ras-related protein Rab-3B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:35871249). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:35871249). {ECO:0000269|PubMed:35871249}. |
| P20339 | RAB5A | S84 | psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P31946 | YWHAB | T32 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P51149 | RAB7A | S72 | ochoa|psp | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
| P51159 | RAB27A | S83 | ochoa | Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000269|PubMed:18812475, ECO:0000269|PubMed:30771381}. |
| P57053 | H2BC12L | T89 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | T89 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P61006 | RAB8A | T72 | ochoa|psp | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}. |
| P61019 | RAB2A | S70 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P61026 | RAB10 | T73 | ochoa|psp | Ras-related protein Rab-10 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. |
| P61225 | RAP2B | S66 | ochoa | Ras-related protein Rap-2b (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}. |
| P62807 | H2BC4 | T89 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P62820 | RAB1A | T75 | ochoa|psp | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}. |
| P62979 | RPS27A | T55 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T55 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P63104 | YWHAZ | T30 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68363 | TUBA1B | T80 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q15286 | RAB35 | T72 | ochoa | Ras-related protein Rab-35 (EC 3.6.5.2) (GTP-binding protein RAY) (Ras-related protein Rab-1C) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:30905672). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:21951725). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (PubMed:16950109). May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:30905672}. |
| Q16778 | H2BC21 | T89 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q5QNW6 | H2BC18 | T89 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6IQ22 | RAB12 | S106 | ochoa|psp | Ras-related protein Rab-12 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}. |
| Q71U36 | TUBA1A | T80 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q8WUD1 | RAB2B | S70 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q92930 | RAB8B | T72 | ochoa | Ras-related protein Rab-8B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}. |
| Q93079 | H2BC9 | T89 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96E17 | RAB3C | T94 | ochoa | Ras-related protein Rab-3C (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}. |
| Q99877 | H2BC15 | T89 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | T89 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | T89 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BQE3 | TUBA1C | T80 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H0U4 | RAB1B | T72 | ochoa | Ras-related protein Rab-1B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}. |
| Q9Y3L5 | RAP2C | S66 | ochoa | Ras-related protein Rap-2c (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. {ECO:0000269|PubMed:17447155}. |
| P61981 | YWHAG | T31 | Sugiyama | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| Q04917 | YWHAH | T31 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P27348 | YWHAQ | T30 | Sugiyama | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P0DPH7 | TUBA3C | T80 | Sugiyama | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PEY2 | TUBA3E | T80 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-171306 | Packaging Of Telomere Ends | 1.110223e-16 | 15.955 |
| R-HSA-5334118 | DNA methylation | 1.110223e-16 | 15.955 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.110223e-16 | 15.955 |
| R-HSA-8852135 | Protein ubiquitination | 1.110223e-16 | 15.955 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.110223e-16 | 15.955 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.110223e-16 | 15.955 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.110223e-16 | 15.955 |
| R-HSA-9609690 | HCMV Early Events | 1.110223e-16 | 15.955 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.110223e-16 | 15.955 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.110223e-16 | 15.955 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.110223e-16 | 15.955 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-199991 | Membrane Trafficking | 1.110223e-16 | 15.955 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.110223e-16 | 15.955 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.110223e-16 | 15.955 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.110223e-16 | 15.955 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.110223e-16 | 15.955 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.110223e-16 | 15.955 |
| R-HSA-68886 | M Phase | 1.110223e-16 | 15.955 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.110223e-16 | 15.955 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.110223e-16 | 15.955 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.110223e-16 | 15.955 |
| R-HSA-1640170 | Cell Cycle | 1.110223e-16 | 15.955 |
| R-HSA-597592 | Post-translational protein modification | 1.110223e-16 | 15.955 |
| R-HSA-392499 | Metabolism of proteins | 1.110223e-16 | 15.955 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.110223e-16 | 15.955 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.110223e-16 | 15.955 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.110223e-16 | 15.955 |
| R-HSA-977225 | Amyloid fiber formation | 1.110223e-16 | 15.955 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.110223e-16 | 15.955 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.110223e-16 | 15.955 |
| R-HSA-69481 | G2/M Checkpoints | 1.110223e-16 | 15.955 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.110223e-16 | 15.955 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.110223e-16 | 15.955 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.110223e-16 | 15.955 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.110223e-16 | 15.955 |
| R-HSA-69306 | DNA Replication | 1.110223e-16 | 15.955 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.110223e-16 | 15.955 |
| R-HSA-5693538 | Homology Directed Repair | 1.110223e-16 | 15.955 |
| R-HSA-9824446 | Viral Infection Pathways | 1.110223e-16 | 15.955 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.110223e-16 | 15.955 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.220446e-16 | 15.654 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.220446e-16 | 15.654 |
| R-HSA-68875 | Mitotic Prophase | 2.220446e-16 | 15.654 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.220446e-16 | 15.654 |
| R-HSA-73927 | Depurination | 2.220446e-16 | 15.654 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.440892e-16 | 15.353 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.440892e-16 | 15.353 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.551115e-16 | 15.256 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.551115e-16 | 15.256 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.771561e-16 | 15.109 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.771561e-16 | 15.109 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.771561e-16 | 15.109 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 7.771561e-16 | 15.109 |
| R-HSA-73928 | Depyrimidination | 7.771561e-16 | 15.109 |
| R-HSA-9710421 | Defective pyroptosis | 8.881784e-16 | 15.051 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.332268e-15 | 14.875 |
| R-HSA-774815 | Nucleosome assembly | 1.332268e-15 | 14.875 |
| R-HSA-2559583 | Cellular Senescence | 1.221245e-15 | 14.913 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.665335e-15 | 14.778 |
| R-HSA-157118 | Signaling by NOTCH | 1.776357e-15 | 14.750 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.331468e-15 | 14.632 |
| R-HSA-9609646 | HCMV Infection | 2.997602e-15 | 14.523 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.441691e-15 | 14.463 |
| R-HSA-912446 | Meiotic recombination | 3.885781e-15 | 14.411 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.107825e-15 | 14.386 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.662937e-15 | 14.331 |
| R-HSA-1221632 | Meiotic synapsis | 5.440093e-15 | 14.264 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.440093e-15 | 14.264 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.439294e-15 | 14.191 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.438494e-15 | 14.129 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.660539e-15 | 14.116 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.187939e-14 | 13.925 |
| R-HSA-418990 | Adherens junctions interactions | 1.354472e-14 | 13.868 |
| R-HSA-1280218 | Adaptive Immune System | 1.432188e-14 | 13.844 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.587619e-14 | 13.799 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.587619e-14 | 13.799 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.109424e-14 | 13.676 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.109424e-14 | 13.676 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.109424e-14 | 13.676 |
| R-HSA-195721 | Signaling by WNT | 3.175238e-14 | 13.498 |
| R-HSA-9646399 | Aggrephagy | 3.452794e-14 | 13.462 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.652634e-14 | 13.437 |
| R-HSA-5663205 | Infectious disease | 4.707346e-14 | 13.327 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.740652e-14 | 13.324 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.117329e-14 | 13.213 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.938894e-14 | 13.159 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.938894e-14 | 13.159 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.117329e-14 | 13.213 |
| R-HSA-421270 | Cell-cell junction organization | 7.760459e-14 | 13.110 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.849277e-14 | 13.105 |
| R-HSA-5688426 | Deubiquitination | 9.447998e-14 | 13.025 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.266764e-13 | 12.897 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.596501e-13 | 12.797 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.999512e-13 | 12.699 |
| R-HSA-446728 | Cell junction organization | 2.770006e-13 | 12.558 |
| R-HSA-1500620 | Meiosis | 3.436140e-13 | 12.464 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.188072e-13 | 12.285 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.987744e-13 | 12.156 |
| R-HSA-73884 | Base Excision Repair | 6.333822e-13 | 12.198 |
| R-HSA-2262752 | Cellular responses to stress | 1.079248e-12 | 11.967 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.182610e-12 | 11.927 |
| R-HSA-1500931 | Cell-Cell communication | 1.371459e-12 | 11.863 |
| R-HSA-157579 | Telomere Maintenance | 1.481482e-12 | 11.829 |
| R-HSA-3214847 | HATs acetylate histones | 1.771805e-12 | 11.752 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.303158e-12 | 11.638 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.972844e-12 | 11.527 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.972844e-12 | 11.527 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.511080e-12 | 11.455 |
| R-HSA-211000 | Gene Silencing by RNA | 3.811507e-12 | 11.419 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.149192e-12 | 11.211 |
| R-HSA-73894 | DNA Repair | 6.995959e-12 | 11.155 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.635959e-12 | 11.016 |
| R-HSA-1266738 | Developmental Biology | 1.116618e-11 | 10.952 |
| R-HSA-73886 | Chromosome Maintenance | 1.297784e-11 | 10.887 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.496570e-11 | 10.825 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.845923e-11 | 10.734 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.845923e-11 | 10.734 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.845923e-11 | 10.734 |
| R-HSA-9663891 | Selective autophagy | 2.094014e-11 | 10.679 |
| R-HSA-1474165 | Reproduction | 2.770428e-11 | 10.557 |
| R-HSA-69275 | G2/M Transition | 3.366307e-11 | 10.473 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.728984e-11 | 10.428 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.355405e-11 | 10.361 |
| R-HSA-168256 | Immune System | 1.243584e-10 | 9.905 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.344781e-10 | 9.871 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.313174e-10 | 9.636 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.649078e-10 | 9.577 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.262457e-10 | 9.370 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 9.079266e-10 | 9.042 |
| R-HSA-1643685 | Disease | 1.317757e-09 | 8.880 |
| R-HSA-1632852 | Macroautophagy | 1.468887e-09 | 8.833 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.114847e-09 | 8.675 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.670553e-09 | 8.573 |
| R-HSA-68882 | Mitotic Anaphase | 2.749416e-09 | 8.561 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.861637e-09 | 8.543 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.053678e-09 | 8.515 |
| R-HSA-9612973 | Autophagy | 3.372942e-09 | 8.472 |
| R-HSA-9610379 | HCMV Late Events | 3.543294e-09 | 8.451 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 4.635561e-09 | 8.334 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 4.635561e-09 | 8.334 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 4.635561e-09 | 8.334 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.393010e-09 | 8.357 |
| R-HSA-109581 | Apoptosis | 4.513493e-09 | 8.345 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.503551e-09 | 8.259 |
| R-HSA-8939211 | ESR-mediated signaling | 6.147051e-09 | 8.211 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 8.093056e-09 | 8.092 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.609233e-09 | 8.065 |
| R-HSA-4839726 | Chromatin organization | 9.440048e-09 | 8.025 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.581080e-09 | 8.019 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.193793e-08 | 7.923 |
| R-HSA-9683683 | Maturation of protein E | 1.377489e-08 | 7.861 |
| R-HSA-9694493 | Maturation of protein E | 1.377489e-08 | 7.861 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.423122e-08 | 7.847 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.600420e-08 | 7.796 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.802885e-08 | 7.744 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.759900e-08 | 7.559 |
| R-HSA-5357801 | Programmed Cell Death | 3.031279e-08 | 7.518 |
| R-HSA-8948747 | Regulation of PTEN localization | 3.347681e-08 | 7.475 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.434241e-08 | 7.353 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.446323e-08 | 7.352 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.447936e-08 | 7.352 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.447936e-08 | 7.352 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 4.890157e-08 | 7.311 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 4.890157e-08 | 7.311 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 4.890157e-08 | 7.311 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 4.890157e-08 | 7.311 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 4.890157e-08 | 7.311 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 6.910111e-08 | 7.161 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 9.496017e-08 | 7.022 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.057191e-08 | 7.043 |
| R-HSA-5689877 | Josephin domain DUBs | 9.496017e-08 | 7.022 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 8.214176e-08 | 7.085 |
| R-HSA-9664873 | Pexophagy | 9.496017e-08 | 7.022 |
| R-HSA-212436 | Generic Transcription Pathway | 9.641827e-08 | 7.016 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.088078e-07 | 6.963 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.244931e-07 | 6.905 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.274349e-07 | 6.895 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.274349e-07 | 6.895 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.274349e-07 | 6.895 |
| R-HSA-162582 | Signal Transduction | 1.600635e-07 | 6.796 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.612272e-07 | 6.793 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.675519e-07 | 6.776 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.675519e-07 | 6.776 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.675519e-07 | 6.776 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.772072e-07 | 6.752 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.841175e-07 | 6.735 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.980866e-07 | 6.703 |
| R-HSA-190861 | Gap junction assembly | 2.060691e-07 | 6.686 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.164076e-07 | 6.665 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.164076e-07 | 6.665 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.164076e-07 | 6.665 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.164076e-07 | 6.665 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.164076e-07 | 6.665 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.164076e-07 | 6.665 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.164076e-07 | 6.665 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.490488e-07 | 6.604 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.751671e-07 | 6.560 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.912894e-07 | 6.536 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 4.273973e-07 | 6.369 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 3.450635e-07 | 6.462 |
| R-HSA-110312 | Translesion synthesis by REV1 | 4.273973e-07 | 6.369 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.458869e-07 | 6.351 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.913909e-07 | 6.407 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.450635e-07 | 6.462 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.022708e-07 | 6.395 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 3.450635e-07 | 6.462 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.042079e-07 | 6.393 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 4.273973e-07 | 6.369 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 4.273973e-07 | 6.369 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 4.273973e-07 | 6.369 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 3.450635e-07 | 6.462 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.931605e-07 | 6.307 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 4.273973e-07 | 6.369 |
| R-HSA-193639 | p75NTR signals via NF-kB | 4.273973e-07 | 6.369 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.931605e-07 | 6.307 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.747282e-07 | 6.426 |
| R-HSA-5656121 | Translesion synthesis by POLI | 5.235350e-07 | 6.281 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.235350e-07 | 6.281 |
| R-HSA-9708530 | Regulation of BACH1 activity | 5.235350e-07 | 6.281 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.235350e-07 | 6.281 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.443111e-07 | 6.264 |
| R-HSA-8854214 | TBC/RABGAPs | 5.995666e-07 | 6.222 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.048499e-07 | 6.218 |
| R-HSA-5655862 | Translesion synthesis by POLK | 6.349087e-07 | 6.197 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 6.349087e-07 | 6.197 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 6.349087e-07 | 6.197 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 6.349087e-07 | 6.197 |
| R-HSA-190828 | Gap junction trafficking | 6.591628e-07 | 6.181 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 7.630154e-07 | 6.117 |
| R-HSA-3229121 | Glycogen storage diseases | 7.630154e-07 | 6.117 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 8.664782e-07 | 6.062 |
| R-HSA-437239 | Recycling pathway of L1 | 8.664782e-07 | 6.062 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.094157e-07 | 6.041 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 9.094157e-07 | 6.041 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.031092e-06 | 5.987 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.075733e-06 | 5.968 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.075733e-06 | 5.968 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.075733e-06 | 5.968 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.075733e-06 | 5.968 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.263654e-06 | 5.898 |
| R-HSA-3322077 | Glycogen synthesis | 1.263654e-06 | 5.898 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.474926e-06 | 5.831 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.474926e-06 | 5.831 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.474926e-06 | 5.831 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 1.474926e-06 | 5.831 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.474926e-06 | 5.831 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.474926e-06 | 5.831 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.677116e-06 | 5.775 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.711357e-06 | 5.767 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.711357e-06 | 5.767 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.711357e-06 | 5.767 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.711357e-06 | 5.767 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.711357e-06 | 5.767 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.810296e-06 | 5.742 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.974815e-06 | 5.704 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.974815e-06 | 5.704 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.154307e-06 | 5.667 |
| R-HSA-983189 | Kinesins | 2.428583e-06 | 5.615 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.590579e-06 | 5.587 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.338332e-06 | 5.476 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.338332e-06 | 5.476 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.338332e-06 | 5.476 |
| R-HSA-74160 | Gene expression (Transcription) | 3.619604e-06 | 5.441 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.766989e-06 | 5.424 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.766989e-06 | 5.424 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.766989e-06 | 5.424 |
| R-HSA-5617833 | Cilium Assembly | 3.799481e-06 | 5.420 |
| R-HSA-913531 | Interferon Signaling | 3.885963e-06 | 5.411 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.021159e-06 | 5.396 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.021159e-06 | 5.396 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.157134e-06 | 5.381 |
| R-HSA-68877 | Mitotic Prometaphase | 4.168664e-06 | 5.380 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.235096e-06 | 5.373 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.235096e-06 | 5.373 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.371564e-06 | 5.359 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.744918e-06 | 5.324 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.744918e-06 | 5.324 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.744918e-06 | 5.324 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.744918e-06 | 5.324 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.744918e-06 | 5.324 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 5.899045e-06 | 5.229 |
| R-HSA-5696400 | Dual Incision in GG-NER | 8.813476e-06 | 5.055 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9.683187e-06 | 5.014 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 9.683187e-06 | 5.014 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.002809e-06 | 5.097 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.298777e-06 | 5.276 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.899045e-06 | 5.229 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 8.002809e-06 | 5.097 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 8.813476e-06 | 5.055 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 8.813476e-06 | 5.055 |
| R-HSA-169911 | Regulation of Apoptosis | 9.683187e-06 | 5.014 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 7.248558e-06 | 5.140 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.899045e-06 | 5.229 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 8.813476e-06 | 5.055 |
| R-HSA-182971 | EGFR downregulation | 5.899045e-06 | 5.229 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6.548146e-06 | 5.184 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.147866e-06 | 5.288 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 8.813476e-06 | 5.055 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 7.248558e-06 | 5.140 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.994243e-06 | 5.222 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.899045e-06 | 5.229 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 8.813476e-06 | 5.055 |
| R-HSA-1980145 | Signaling by NOTCH2 | 8.813476e-06 | 5.055 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 8.813476e-06 | 5.055 |
| R-HSA-2559585 | Oncogene Induced Senescence | 9.683187e-06 | 5.014 |
| R-HSA-5205647 | Mitophagy | 8.813476e-06 | 5.055 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.414302e-06 | 5.075 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.474965e-06 | 5.072 |
| R-HSA-9679506 | SARS-CoV Infections | 9.460766e-06 | 5.024 |
| R-HSA-9833482 | PKR-mediated signaling | 8.414302e-06 | 5.075 |
| R-HSA-422475 | Axon guidance | 8.125980e-06 | 5.090 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.061462e-05 | 4.974 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.061462e-05 | 4.974 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.061462e-05 | 4.974 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.061462e-05 | 4.974 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.153943e-05 | 4.938 |
| R-HSA-4641258 | Degradation of DVL | 1.161049e-05 | 4.935 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.161049e-05 | 4.935 |
| R-HSA-4641257 | Degradation of AXIN | 1.161049e-05 | 4.935 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.161049e-05 | 4.935 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.161049e-05 | 4.935 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.267359e-05 | 4.897 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.276090e-05 | 4.894 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.276090e-05 | 4.894 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.380672e-05 | 4.860 |
| R-HSA-69541 | Stabilization of p53 | 1.380672e-05 | 4.860 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.380672e-05 | 4.860 |
| R-HSA-9648002 | RAS processing | 1.380672e-05 | 4.860 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.380672e-05 | 4.860 |
| R-HSA-9675108 | Nervous system development | 1.405501e-05 | 4.852 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.501274e-05 | 4.824 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.501274e-05 | 4.824 |
| R-HSA-8982491 | Glycogen metabolism | 1.501274e-05 | 4.824 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.629458e-05 | 4.788 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.629458e-05 | 4.788 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.629458e-05 | 4.788 |
| R-HSA-9607240 | FLT3 Signaling | 1.629458e-05 | 4.788 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.694569e-05 | 4.771 |
| R-HSA-391251 | Protein folding | 1.703991e-05 | 4.769 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.765518e-05 | 4.753 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.765518e-05 | 4.753 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.765518e-05 | 4.753 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.765518e-05 | 4.753 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.765518e-05 | 4.753 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.956067e-05 | 4.709 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.062472e-05 | 4.686 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.062472e-05 | 4.686 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.062472e-05 | 4.686 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.221949e-05 | 4.653 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.223979e-05 | 4.653 |
| R-HSA-69236 | G1 Phase | 2.223979e-05 | 4.653 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.223979e-05 | 4.653 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.394587e-05 | 4.621 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.394587e-05 | 4.621 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.394587e-05 | 4.621 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.394587e-05 | 4.621 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.394587e-05 | 4.621 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.394587e-05 | 4.621 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.394587e-05 | 4.621 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.574614e-05 | 4.589 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.574614e-05 | 4.589 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.574614e-05 | 4.589 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.574614e-05 | 4.589 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.764380e-05 | 4.558 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.764380e-05 | 4.558 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.771739e-05 | 4.557 |
| R-HSA-5620924 | Intraflagellar transport | 2.964211e-05 | 4.528 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.084025e-05 | 4.511 |
| R-HSA-9833110 | RSV-host interactions | 3.137773e-05 | 4.503 |
| R-HSA-73893 | DNA Damage Bypass | 3.174435e-05 | 4.498 |
| R-HSA-9766229 | Degradation of CDH1 | 3.174435e-05 | 4.498 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.174435e-05 | 4.498 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.174435e-05 | 4.498 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.174435e-05 | 4.498 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.174435e-05 | 4.498 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.395386e-05 | 4.469 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.627399e-05 | 4.440 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.627399e-05 | 4.440 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.627399e-05 | 4.440 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.870816e-05 | 4.412 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.870816e-05 | 4.412 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.870816e-05 | 4.412 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.870816e-05 | 4.412 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.125980e-05 | 4.384 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.125980e-05 | 4.384 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.125980e-05 | 4.384 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.393239e-05 | 4.357 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.672944e-05 | 4.330 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.672944e-05 | 4.330 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.965451e-05 | 4.304 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.965451e-05 | 4.304 |
| R-HSA-75893 | TNF signaling | 4.965451e-05 | 4.304 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.965451e-05 | 4.304 |
| R-HSA-177929 | Signaling by EGFR | 4.965451e-05 | 4.304 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.965451e-05 | 4.304 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.991933e-05 | 4.302 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.271117e-05 | 4.278 |
| R-HSA-373760 | L1CAM interactions | 5.369294e-05 | 4.270 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.590304e-05 | 4.253 |
| R-HSA-9033241 | Peroxisomal protein import | 5.923378e-05 | 4.227 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.270706e-05 | 4.203 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.270706e-05 | 4.203 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.270706e-05 | 4.203 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.270706e-05 | 4.203 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.270706e-05 | 4.203 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.270706e-05 | 4.203 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.632661e-05 | 4.178 |
| R-HSA-450294 | MAP kinase activation | 6.632661e-05 | 4.178 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.009617e-05 | 4.154 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.401951e-05 | 4.131 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.401951e-05 | 4.131 |
| R-HSA-8848021 | Signaling by PTK6 | 7.401951e-05 | 4.131 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.810046e-05 | 4.107 |
| R-HSA-1234174 | Cellular response to hypoxia | 8.234284e-05 | 4.084 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.425006e-05 | 4.074 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.448029e-05 | 4.073 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.132743e-05 | 4.039 |
| R-HSA-5218859 | Regulated Necrosis | 9.607746e-05 | 4.017 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.061128e-04 | 3.974 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.061128e-04 | 3.974 |
| R-HSA-448424 | Interleukin-17 signaling | 1.061128e-04 | 3.974 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.061128e-04 | 3.974 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.061128e-04 | 3.974 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.074481e-04 | 3.969 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.114060e-04 | 3.953 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.114060e-04 | 3.953 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.114060e-04 | 3.953 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.114060e-04 | 3.953 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.168884e-04 | 3.932 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.220771e-04 | 3.913 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.225639e-04 | 3.912 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.225639e-04 | 3.912 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.225639e-04 | 3.912 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.284368e-04 | 3.891 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.345109e-04 | 3.871 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.345109e-04 | 3.871 |
| R-HSA-917937 | Iron uptake and transport | 1.345109e-04 | 3.871 |
| R-HSA-5689603 | UCH proteinases | 1.407906e-04 | 3.851 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.407906e-04 | 3.851 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.455637e-04 | 3.837 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.472800e-04 | 3.832 |
| R-HSA-5619084 | ABC transporter disorders | 1.539832e-04 | 3.813 |
| R-HSA-4086400 | PCP/CE pathway | 1.539832e-04 | 3.813 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.680479e-04 | 3.775 |
| R-HSA-6806834 | Signaling by MET | 1.680479e-04 | 3.775 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.871078e-04 | 3.728 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.908547e-04 | 3.719 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.989301e-04 | 3.701 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.072491e-04 | 3.684 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.246358e-04 | 3.649 |
| R-HSA-70268 | Pyruvate metabolism | 2.337123e-04 | 3.631 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.526533e-04 | 3.597 |
| R-HSA-202424 | Downstream TCR signaling | 2.625267e-04 | 3.581 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.938123e-04 | 3.532 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.938123e-04 | 3.532 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.276902e-04 | 3.485 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.395801e-04 | 3.469 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.517761e-04 | 3.454 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.642829e-04 | 3.439 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.642829e-04 | 3.439 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.771050e-04 | 3.424 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.771050e-04 | 3.424 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.771050e-04 | 3.424 |
| R-HSA-190236 | Signaling by FGFR | 3.771050e-04 | 3.424 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.902471e-04 | 3.409 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.902471e-04 | 3.409 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.037138e-04 | 3.394 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.175096e-04 | 3.379 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.609187e-04 | 3.336 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.915892e-04 | 3.308 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.915892e-04 | 3.308 |
| R-HSA-69239 | Synthesis of DNA | 5.236883e-04 | 3.281 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.236883e-04 | 3.281 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.236883e-04 | 3.281 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.402853e-04 | 3.267 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.402853e-04 | 3.267 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.402853e-04 | 3.267 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.572536e-04 | 3.254 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.745978e-04 | 3.241 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.745978e-04 | 3.241 |
| R-HSA-202403 | TCR signaling | 5.745978e-04 | 3.241 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.289335e-04 | 3.201 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.298033e-04 | 3.201 |
| R-HSA-6798695 | Neutrophil degranulation | 6.613089e-04 | 3.180 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.644595e-04 | 3.178 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.868234e-04 | 3.163 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.069321e-04 | 3.151 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.670239e-04 | 3.115 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.915537e-04 | 3.102 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.915537e-04 | 3.102 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.915537e-04 | 3.102 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.364437e-04 | 3.078 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.595502e-04 | 3.066 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.595502e-04 | 3.066 |
| R-HSA-162909 | Host Interactions of HIV factors | 9.071102e-04 | 3.042 |
| R-HSA-69206 | G1/S Transition | 9.564983e-04 | 3.019 |
| R-HSA-9909396 | Circadian clock | 1.173098e-03 | 2.931 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.324729e-03 | 2.878 |
| R-HSA-6807070 | PTEN Regulation | 1.422017e-03 | 2.847 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.559362e-03 | 2.807 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.559362e-03 | 2.807 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.631390e-03 | 2.787 |
| R-HSA-9824439 | Bacterial Infection Pathways | 1.677273e-03 | 2.775 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.705705e-03 | 2.768 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.745936e-03 | 2.758 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.782346e-03 | 2.749 |
| R-HSA-69242 | S Phase | 1.782346e-03 | 2.749 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.879110e-03 | 2.726 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.901751e-03 | 2.721 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.942756e-03 | 2.712 |
| R-HSA-9609507 | Protein localization | 1.984371e-03 | 2.702 |
| R-HSA-73887 | Death Receptor Signaling | 2.026601e-03 | 2.693 |
| R-HSA-162587 | HIV Life Cycle | 2.157023e-03 | 2.666 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.201757e-03 | 2.657 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.293143e-03 | 2.640 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.293143e-03 | 2.640 |
| R-HSA-168249 | Innate Immune System | 2.474991e-03 | 2.606 |
| R-HSA-392517 | Rap1 signalling | 2.594673e-03 | 2.586 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.689679e-03 | 2.570 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.897109e-03 | 2.538 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.960123e-03 | 2.529 |
| R-HSA-109582 | Hemostasis | 3.184720e-03 | 2.497 |
| R-HSA-156902 | Peptide chain elongation | 3.468006e-03 | 2.460 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.671028e-03 | 2.435 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.775210e-03 | 2.423 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.881184e-03 | 2.411 |
| R-HSA-112316 | Neuronal System | 3.964024e-03 | 2.402 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.988960e-03 | 2.399 |
| R-HSA-983712 | Ion channel transport | 3.995011e-03 | 2.398 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.132167e-03 | 2.384 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.438275e-03 | 2.353 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.438275e-03 | 2.353 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.022661e-03 | 2.299 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.167851e-03 | 2.287 |
| R-HSA-192823 | Viral mRNA Translation | 5.426140e-03 | 2.266 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.558152e-03 | 2.255 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.559074e-03 | 2.255 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.105490e-03 | 2.214 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.247185e-03 | 2.204 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.247185e-03 | 2.204 |
| R-HSA-8951664 | Neddylation | 6.682790e-03 | 2.175 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.833615e-03 | 2.165 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.833615e-03 | 2.165 |
| R-HSA-162906 | HIV Infection | 7.274414e-03 | 2.138 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 7.322405e-03 | 2.135 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.772951e-03 | 2.109 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.772951e-03 | 2.109 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.494523e-03 | 2.023 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.195037e-02 | 1.923 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.225924e-02 | 1.912 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.238122e-02 | 1.907 |
| R-HSA-72766 | Translation | 1.272292e-02 | 1.895 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.436307e-02 | 1.843 |
| R-HSA-8953854 | Metabolism of RNA | 1.605576e-02 | 1.794 |
| R-HSA-72649 | Translation initiation complex formation | 1.606711e-02 | 1.794 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.606711e-02 | 1.794 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.651109e-02 | 1.782 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.669783e-02 | 1.777 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.705339e-02 | 1.768 |
| R-HSA-9711097 | Cellular response to starvation | 1.746868e-02 | 1.758 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.806491e-02 | 1.743 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.906953e-02 | 1.720 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.070192e-02 | 1.684 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.070192e-02 | 1.684 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.103716e-02 | 1.677 |
| R-HSA-9636569 | Suppression of autophagy | 2.150520e-02 | 1.667 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.235667e-02 | 1.651 |
| R-HSA-168255 | Influenza Infection | 2.372560e-02 | 1.625 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.503012e-02 | 1.602 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.569001e-02 | 1.590 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.591777e-02 | 1.586 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.642224e-02 | 1.578 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.659265e-02 | 1.575 |
| R-HSA-380287 | Centrosome maturation | 2.763498e-02 | 1.559 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 3.058236e-02 | 1.515 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 3.358970e-02 | 1.474 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 3.358970e-02 | 1.474 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 3.658790e-02 | 1.437 |
| R-HSA-170984 | ARMS-mediated activation | 3.658790e-02 | 1.437 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 3.658790e-02 | 1.437 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.660306e-02 | 1.436 |
| R-HSA-72312 | rRNA processing | 4.358480e-02 | 1.361 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.630173e-02 | 1.334 |
| R-HSA-449147 | Signaling by Interleukins | 4.947741e-02 | 1.306 |
| R-HSA-5668914 | Diseases of metabolism | 5.017987e-02 | 1.299 |
| R-HSA-170968 | Frs2-mediated activation | 5.144270e-02 | 1.289 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 5.732156e-02 | 1.242 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 5.732156e-02 | 1.242 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.009373e-02 | 1.221 |
| R-HSA-169893 | Prolonged ERK activation events | 6.024758e-02 | 1.220 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 6.024758e-02 | 1.220 |
| R-HSA-2028269 | Signaling by Hippo | 6.607296e-02 | 1.180 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 6.897236e-02 | 1.161 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 7.474472e-02 | 1.126 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 7.761774e-02 | 1.110 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 8.333757e-02 | 1.079 |
| R-HSA-166208 | mTORC1-mediated signalling | 8.333757e-02 | 1.079 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 8.902263e-02 | 1.050 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 9.467313e-02 | 1.024 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.605288e-02 | 1.017 |
| R-HSA-264876 | Insulin processing | 9.748549e-02 | 1.011 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.058713e-01 | 0.975 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.086496e-01 | 0.964 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.086496e-01 | 0.964 |
| R-HSA-5673000 | RAF activation | 1.196783e-01 | 0.922 |
| R-HSA-187687 | Signalling to ERKs | 1.224145e-01 | 0.912 |
| R-HSA-3371511 | HSF1 activation | 1.251423e-01 | 0.903 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.278619e-01 | 0.893 |
| R-HSA-3371568 | Attenuation phase | 1.359710e-01 | 0.867 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.413359e-01 | 0.850 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.413359e-01 | 0.850 |
| R-HSA-165159 | MTOR signalling | 1.440062e-01 | 0.842 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.546059e-01 | 0.811 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.546059e-01 | 0.811 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.546059e-01 | 0.811 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.546059e-01 | 0.811 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.676748e-01 | 0.776 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.957335e-01 | 0.708 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.032236e-01 | 0.692 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.106453e-01 | 0.676 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.319245e-01 | 0.635 |
| R-HSA-9659379 | Sensory processing of sound | 2.372831e-01 | 0.625 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.514394e-01 | 0.600 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.537736e-01 | 0.596 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.537736e-01 | 0.596 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.653381e-01 | 0.576 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.923811e-01 | 0.534 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.967924e-01 | 0.528 |
| R-HSA-1483255 | PI Metabolism | 2.967924e-01 | 0.528 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.188954e-01 | 0.496 |
| R-HSA-2980736 | Peptide hormone metabolism | 3.353004e-01 | 0.475 |
| R-HSA-3371556 | Cellular response to heat stress | 3.435728e-01 | 0.464 |
| R-HSA-114608 | Platelet degranulation | 3.578075e-01 | 0.446 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.598162e-01 | 0.444 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.717395e-01 | 0.430 |
| R-HSA-382551 | Transport of small molecules | 3.784071e-01 | 0.422 |
| R-HSA-166520 | Signaling by NTRKs | 4.043530e-01 | 0.393 |
| R-HSA-1483257 | Phospholipid metabolism | 6.275944e-01 | 0.202 |
| R-HSA-9709957 | Sensory Perception | 9.828734e-01 | 0.008 |
| R-HSA-1430728 | Metabolism | 9.863051e-01 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 9.926991e-01 | 0.003 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
DMPK1 |
0.553 | 0.277 | -3 | 0.735 |
CHK2 |
0.552 | 0.288 | -3 | 0.728 |
HPK1 |
0.550 | 0.245 | 1 | 0.526 |
DAPK1 |
0.549 | 0.247 | -3 | 0.678 |
DAPK3 |
0.549 | 0.252 | -3 | 0.691 |
KHS2 |
0.548 | 0.215 | 1 | 0.526 |
ROCK1 |
0.546 | 0.256 | -3 | 0.685 |
CLK4 |
0.545 | 0.276 | -3 | 0.708 |
KHS1 |
0.545 | 0.205 | 1 | 0.541 |
SGK1 |
0.545 | 0.253 | -3 | 0.706 |
GCK |
0.545 | 0.204 | 1 | 0.494 |
SLK |
0.544 | 0.195 | -2 | 0.616 |
MRCKB |
0.543 | 0.263 | -3 | 0.691 |
ROCK2 |
0.543 | 0.245 | -3 | 0.665 |
TAO3 |
0.542 | 0.195 | 1 | 0.422 |
AKT2 |
0.541 | 0.269 | -3 | 0.718 |
SMMLCK |
0.541 | 0.244 | -3 | 0.613 |
CLK1 |
0.541 | 0.280 | -3 | 0.722 |
CLK2 |
0.540 | 0.269 | -3 | 0.740 |
GAK |
0.540 | 0.150 | 1 | 0.401 |
PIM1 |
0.540 | 0.242 | -3 | 0.700 |
AKT1 |
0.539 | 0.279 | -3 | 0.710 |
MRCKA |
0.539 | 0.238 | -3 | 0.694 |
LOK |
0.539 | 0.204 | -2 | 0.623 |
SGK3 |
0.539 | 0.261 | -3 | 0.646 |
PDK1 |
0.539 | 0.170 | 1 | 0.411 |
MINK |
0.538 | 0.170 | 1 | 0.517 |
MST3 |
0.538 | 0.182 | 2 | 0.491 |
TNIK |
0.537 | 0.165 | 3 | 0.553 |
HASPIN |
0.537 | 0.258 | -1 | 0.711 |
PIM2 |
0.536 | 0.227 | -3 | 0.690 |
NIK |
0.535 | 0.250 | -3 | 0.551 |
PASK |
0.535 | 0.187 | -3 | 0.585 |
TAO2 |
0.534 | 0.164 | 2 | 0.429 |
SBK |
0.534 | 0.221 | -3 | 0.732 |
DAPK2 |
0.534 | 0.213 | -3 | 0.566 |
RAF1 |
0.534 | 0.284 | 1 | 0.502 |
CAMK1B |
0.534 | 0.238 | -3 | 0.612 |
MST1 |
0.533 | 0.144 | 1 | 0.504 |
TAK1 |
0.533 | 0.144 | 1 | 0.448 |
PKN2 |
0.532 | 0.239 | -3 | 0.595 |
MST2 |
0.532 | 0.111 | 1 | 0.516 |
HGK |
0.532 | 0.139 | 3 | 0.544 |
CAMLCK |
0.531 | 0.205 | -2 | 0.590 |
MYLK4 |
0.531 | 0.237 | -2 | 0.580 |
TAO1 |
0.531 | 0.166 | 1 | 0.458 |
CAMK1D |
0.531 | 0.229 | -3 | 0.726 |
AURA |
0.531 | 0.212 | -2 | 0.550 |
NUAK2 |
0.531 | 0.219 | -3 | 0.662 |
MSK1 |
0.530 | 0.260 | -3 | 0.644 |
LRRK2 |
0.530 | 0.158 | 2 | 0.446 |
DCAMKL1 |
0.530 | 0.221 | -3 | 0.712 |
BRAF |
0.530 | 0.112 | -4 | 0.356 |
RSK2 |
0.530 | 0.252 | -3 | 0.691 |
PKACB |
0.530 | 0.263 | -2 | 0.544 |
CHK1 |
0.529 | 0.157 | -3 | 0.614 |
PKR |
0.529 | 0.109 | 1 | 0.383 |
MEKK3 |
0.529 | 0.119 | 1 | 0.433 |
MYO3A |
0.529 | 0.136 | 1 | 0.475 |
MEKK2 |
0.528 | 0.103 | 2 | 0.416 |
CLK3 |
0.528 | 0.199 | 1 | 0.296 |
YSK4 |
0.527 | 0.110 | 1 | 0.469 |
PKCE |
0.527 | 0.216 | 2 | 0.397 |
PIM3 |
0.527 | 0.207 | -3 | 0.649 |
MEK1 |
0.527 | 0.110 | 2 | 0.444 |
SKMLCK |
0.527 | 0.190 | -2 | 0.592 |
MEK5 |
0.527 | 0.136 | 2 | 0.438 |
WNK1 |
0.527 | 0.212 | -2 | 0.586 |
YSK1 |
0.526 | 0.131 | 2 | 0.420 |
DLK |
0.526 | 0.148 | 1 | 0.387 |
PKN3 |
0.526 | 0.183 | -3 | 0.598 |
CRIK |
0.526 | 0.191 | -3 | 0.696 |
AURB |
0.526 | 0.222 | -2 | 0.554 |
PAK1 |
0.526 | 0.215 | -2 | 0.594 |
CDKL1 |
0.526 | 0.195 | -3 | 0.620 |
TSSK1 |
0.526 | 0.175 | -3 | 0.611 |
PKACA |
0.526 | 0.252 | -2 | 0.521 |
P70S6KB |
0.525 | 0.214 | -3 | 0.670 |
WNK4 |
0.525 | 0.155 | -2 | 0.588 |
TSSK2 |
0.525 | 0.127 | -5 | 0.589 |
PKN1 |
0.525 | 0.221 | -3 | 0.662 |
MSK2 |
0.524 | 0.253 | -3 | 0.636 |
DCAMKL2 |
0.524 | 0.184 | -3 | 0.704 |
ANKRD3 |
0.524 | 0.099 | 1 | 0.458 |
CAMK1A |
0.524 | 0.217 | -3 | 0.733 |
PKCD |
0.523 | 0.193 | 2 | 0.405 |
NEK11 |
0.523 | 0.107 | 1 | 0.476 |
SRPK3 |
0.523 | 0.190 | -3 | 0.651 |
MYO3B |
0.523 | 0.097 | 2 | 0.421 |
PAK5 |
0.523 | 0.256 | -2 | 0.621 |
MNK1 |
0.523 | 0.225 | -2 | 0.587 |
ICK |
0.522 | 0.151 | -3 | 0.600 |
MST4 |
0.522 | 0.172 | 2 | 0.437 |
CAMK1G |
0.522 | 0.201 | -3 | 0.674 |
DRAK1 |
0.522 | 0.127 | 1 | 0.266 |
RSK4 |
0.522 | 0.232 | -3 | 0.708 |
PKCH |
0.522 | 0.192 | 2 | 0.385 |
CAMK4 |
0.522 | 0.202 | -3 | 0.637 |
DYRK3 |
0.521 | 0.172 | 1 | 0.237 |
PKCI |
0.521 | 0.200 | 2 | 0.401 |
NEK8 |
0.521 | 0.071 | 2 | 0.443 |
SIK |
0.521 | 0.213 | -3 | 0.676 |
PKACG |
0.521 | 0.231 | -2 | 0.558 |
LATS1 |
0.521 | 0.098 | -3 | 0.601 |
AKT3 |
0.521 | 0.235 | -3 | 0.707 |
PRKD3 |
0.520 | 0.219 | -3 | 0.684 |
MEKK6 |
0.520 | 0.072 | 1 | 0.403 |
PAK2 |
0.520 | 0.180 | -2 | 0.601 |
CAMKK2 |
0.519 | 0.064 | -2 | 0.549 |
PAK6 |
0.519 | 0.250 | -2 | 0.611 |
MAP3K15 |
0.519 | 0.068 | 1 | 0.428 |
PBK |
0.518 | 0.069 | 1 | 0.405 |
IKKB |
0.518 | 0.216 | -2 | 0.531 |
PRKD2 |
0.518 | 0.232 | -3 | 0.687 |
SRPK1 |
0.518 | 0.194 | -3 | 0.667 |
MAPKAPK3 |
0.518 | 0.203 | -3 | 0.637 |
PKCZ |
0.518 | 0.152 | 2 | 0.417 |
PHKG2 |
0.517 | 0.250 | -3 | 0.678 |
MARK1 |
0.517 | 0.149 | 4 | 0.460 |
OSR1 |
0.517 | 0.053 | 2 | 0.421 |
AMPKA1 |
0.517 | 0.146 | -3 | 0.615 |
PRKX |
0.517 | 0.260 | -3 | 0.753 |
QSK |
0.517 | 0.161 | 4 | 0.484 |
MNK2 |
0.517 | 0.213 | -2 | 0.604 |
MAK |
0.517 | 0.125 | -2 | 0.411 |
MARK3 |
0.517 | 0.144 | 4 | 0.453 |
GRK6 |
0.517 | 0.062 | 1 | 0.393 |
QIK |
0.517 | 0.163 | -3 | 0.553 |
PAK3 |
0.516 | 0.197 | -2 | 0.599 |
EEF2K |
0.516 | 0.018 | 3 | 0.558 |
YANK3 |
0.516 | 0.065 | 2 | 0.226 |
TBK1 |
0.516 | 0.171 | 1 | 0.567 |
CAMKK1 |
0.516 | 0.044 | -2 | 0.522 |
CAMK2B |
0.516 | 0.139 | 2 | 0.390 |
IKKE |
0.516 | 0.187 | 1 | 0.589 |
ZAK |
0.516 | 0.081 | 1 | 0.443 |
CAMK2A |
0.516 | 0.161 | 2 | 0.430 |
VRK2 |
0.516 | -0.054 | 1 | 0.387 |
VRK1 |
0.516 | -0.009 | 2 | 0.447 |
NEK4 |
0.515 | 0.067 | 1 | 0.482 |
P90RSK |
0.515 | 0.211 | -3 | 0.668 |
PKCT |
0.515 | 0.195 | 2 | 0.375 |
PKCG |
0.515 | 0.190 | 2 | 0.408 |
MAPKAPK2 |
0.515 | 0.194 | -3 | 0.697 |
RSK3 |
0.515 | 0.227 | -3 | 0.681 |
MEKK1 |
0.515 | 0.070 | 1 | 0.491 |
BUB1 |
0.514 | 0.091 | -5 | 0.592 |
MARK2 |
0.514 | 0.117 | 4 | 0.434 |
AURC |
0.514 | 0.226 | -2 | 0.547 |
MELK |
0.514 | 0.176 | -3 | 0.642 |
PKG2 |
0.514 | 0.199 | -2 | 0.527 |
DYRK4 |
0.514 | 0.105 | 1 | 0.182 |
BMPR2 |
0.514 | -0.054 | -2 | 0.486 |
BIKE |
0.513 | 0.043 | 1 | 0.386 |
HIPK1 |
0.513 | 0.105 | 1 | 0.230 |
CAMK2D |
0.513 | 0.140 | -3 | 0.547 |
ALPHAK3 |
0.513 | 0.037 | -1 | 0.318 |
NEK5 |
0.513 | 0.000 | 1 | 0.399 |
PAK4 |
0.512 | 0.235 | -2 | 0.606 |
PKCA |
0.512 | 0.154 | 2 | 0.382 |
JNK2 |
0.512 | 0.011 | 1 | 0.230 |
MEK2 |
0.512 | 0.032 | 2 | 0.391 |
MARK4 |
0.512 | 0.095 | 4 | 0.496 |
NEK1 |
0.512 | 0.024 | 1 | 0.419 |
P70S6K |
0.512 | 0.182 | -3 | 0.653 |
MOS |
0.512 | 0.002 | 1 | 0.365 |
AMPKA2 |
0.512 | 0.145 | -3 | 0.652 |
PKCB |
0.511 | 0.143 | 2 | 0.407 |
STLK3 |
0.511 | 0.055 | 1 | 0.464 |
NEK2 |
0.511 | 0.067 | 2 | 0.421 |
ASK1 |
0.510 | 0.048 | 1 | 0.429 |
TTK |
0.510 | 0.012 | -2 | 0.393 |
ATR |
0.510 | 0.000 | 1 | 0.317 |
NLK |
0.509 | 0.022 | 1 | 0.351 |
HIPK3 |
0.509 | 0.103 | 1 | 0.288 |
MLK1 |
0.509 | 0.049 | 2 | 0.452 |
DYRK2 |
0.509 | 0.077 | 1 | 0.212 |
JNK3 |
0.508 | -0.005 | 1 | 0.224 |
SRPK2 |
0.508 | 0.197 | -3 | 0.685 |
COT |
0.508 | 0.085 | 2 | 0.509 |
TLK2 |
0.508 | -0.017 | 1 | 0.380 |
CDKL5 |
0.507 | 0.134 | -3 | 0.615 |
AAK1 |
0.507 | 0.049 | 1 | 0.345 |
BMPR1B |
0.507 | 0.010 | 1 | 0.318 |
GRK5 |
0.507 | -0.002 | -3 | 0.398 |
PINK1 |
0.507 | 0.035 | 1 | 0.317 |
IRAK1 |
0.506 | 0.062 | -1 | 0.471 |
IRAK4 |
0.506 | 0.057 | 1 | 0.366 |
YANK2 |
0.506 | 0.046 | 2 | 0.225 |
PDHK1 |
0.506 | 0.041 | 1 | 0.504 |
MTOR |
0.506 | 0.066 | 1 | 0.344 |
MASTL |
0.506 | 0.006 | -2 | 0.561 |
PKG1 |
0.506 | 0.214 | -2 | 0.521 |
WNK3 |
0.506 | 0.080 | 1 | 0.420 |
DYRK1B |
0.505 | 0.070 | 1 | 0.221 |
STK33 |
0.505 | 0.067 | 2 | 0.322 |
ALK4 |
0.505 | -0.051 | -2 | 0.395 |
RIPK1 |
0.505 | 0.049 | 1 | 0.365 |
DYRK1A |
0.505 | 0.104 | 1 | 0.259 |
CAMK2G |
0.505 | 0.014 | 2 | 0.395 |
SSTK |
0.505 | 0.095 | 4 | 0.457 |
NDR1 |
0.505 | 0.163 | -3 | 0.638 |
MLK4 |
0.504 | 0.046 | 2 | 0.396 |
PRPK |
0.504 | -0.110 | -1 | 0.408 |
PLK2 |
0.504 | 0.040 | -3 | 0.439 |
HUNK |
0.504 | 0.071 | 2 | 0.468 |
JNK1 |
0.504 | 0.008 | 1 | 0.194 |
MOK |
0.503 | 0.107 | 1 | 0.201 |
CHAK1 |
0.503 | 0.052 | 2 | 0.400 |
DNAPK |
0.503 | 0.005 | 1 | 0.365 |
HIPK2 |
0.503 | 0.084 | 1 | 0.168 |
BMPR1A |
0.503 | 0.007 | 1 | 0.326 |
RIPK3 |
0.503 | 0.069 | 3 | 0.431 |
PERK |
0.503 | -0.042 | -2 | 0.436 |
PLK1 |
0.503 | -0.015 | -2 | 0.405 |
PLK3 |
0.502 | 0.005 | 2 | 0.434 |
GRK7 |
0.502 | -0.003 | 1 | 0.306 |
PRKD1 |
0.502 | 0.128 | -3 | 0.569 |
PDHK4 |
0.502 | -0.027 | 1 | 0.425 |
PRP4 |
0.502 | -0.025 | -3 | 0.279 |
NUAK1 |
0.502 | 0.151 | -3 | 0.692 |
BRSK1 |
0.501 | 0.150 | -3 | 0.665 |
P38A |
0.501 | -0.023 | 1 | 0.242 |
HRI |
0.501 | -0.054 | -2 | 0.444 |
MAPKAPK5 |
0.501 | 0.166 | -3 | 0.581 |
NIM1 |
0.500 | 0.081 | 3 | 0.479 |
ALK2 |
0.500 | -0.043 | -2 | 0.361 |
LKB1 |
0.500 | -0.045 | -3 | 0.325 |
PHKG1 |
0.500 | 0.156 | -3 | 0.635 |
RIPK2 |
0.500 | 0.057 | 1 | 0.487 |
IKKA |
0.499 | 0.089 | -2 | 0.487 |
IRE1 |
0.499 | 0.037 | 1 | 0.316 |
TLK1 |
0.499 | -0.055 | -2 | 0.395 |
NEK9 |
0.498 | -0.038 | 2 | 0.429 |
MLK2 |
0.498 | -0.069 | 2 | 0.427 |
DSTYK |
0.498 | 0.025 | 2 | 0.515 |
CDK10 |
0.498 | 0.069 | 1 | 0.222 |
CDK14 |
0.497 | 0.037 | 1 | 0.237 |
CDC7 |
0.497 | 0.007 | 1 | 0.361 |
CHAK2 |
0.497 | 0.009 | -1 | 0.501 |
NEK3 |
0.496 | 0.015 | 1 | 0.438 |
ACVR2B |
0.496 | -0.056 | -2 | 0.370 |
TTBK2 |
0.495 | 0.007 | 2 | 0.351 |
CDK4 |
0.495 | 0.019 | 1 | 0.204 |
MLK3 |
0.495 | -0.005 | 2 | 0.400 |
BRSK2 |
0.495 | 0.112 | -3 | 0.619 |
ACVR2A |
0.494 | -0.067 | -2 | 0.365 |
MPSK1 |
0.494 | -0.061 | 1 | 0.345 |
CDK6 |
0.494 | 0.007 | 1 | 0.236 |
GRK2 |
0.493 | -0.033 | -2 | 0.384 |
P38G |
0.493 | -0.025 | 1 | 0.156 |
CDK1 |
0.493 | -0.009 | 1 | 0.179 |
TGFBR1 |
0.492 | -0.072 | -2 | 0.357 |
GRK1 |
0.492 | 0.016 | -2 | 0.511 |
ULK2 |
0.491 | -0.008 | 2 | 0.389 |
P38B |
0.491 | -0.043 | 1 | 0.206 |
LATS2 |
0.490 | 0.093 | -5 | 0.399 |
ATM |
0.490 | -0.033 | 1 | 0.299 |
ERK1 |
0.490 | -0.025 | 1 | 0.214 |
GSK3B |
0.490 | -0.011 | 4 | 0.225 |
SNRK |
0.490 | 0.080 | 2 | 0.345 |
GSK3A |
0.489 | -0.006 | 4 | 0.234 |
NEK7 |
0.489 | -0.041 | -3 | 0.309 |
ERK2 |
0.489 | -0.036 | 1 | 0.205 |
BCKDK |
0.488 | 0.002 | -1 | 0.391 |
TGFBR2 |
0.488 | -0.021 | -2 | 0.371 |
GRK4 |
0.488 | -0.030 | -2 | 0.447 |
CDK12 |
0.488 | -0.007 | 1 | 0.215 |
PLK4 |
0.488 | 0.015 | 2 | 0.286 |
SMG1 |
0.487 | -0.066 | 1 | 0.284 |
HIPK4 |
0.487 | 0.051 | 1 | 0.244 |
IRE2 |
0.486 | -0.018 | 2 | 0.371 |
CK1A2 |
0.486 | -0.004 | -3 | 0.253 |
ERK5 |
0.486 | -0.086 | 1 | 0.286 |
GRK3 |
0.485 | -0.026 | -2 | 0.358 |
ERK7 |
0.484 | -0.011 | 2 | 0.348 |
TTBK1 |
0.484 | -0.000 | 2 | 0.312 |
NDR2 |
0.483 | 0.080 | -3 | 0.618 |
P38D |
0.482 | -0.042 | 1 | 0.183 |
CDK9 |
0.482 | -0.026 | 1 | 0.233 |
CDK13 |
0.482 | -0.031 | 1 | 0.225 |
CK1G3 |
0.482 | 0.008 | -3 | 0.195 |
CDK5 |
0.481 | -0.036 | 1 | 0.232 |
CDK2 |
0.481 | -0.038 | 1 | 0.225 |
GCN2 |
0.479 | -0.053 | 2 | 0.410 |
CDK18 |
0.478 | -0.016 | 1 | 0.184 |
CDK16 |
0.478 | -0.016 | 1 | 0.167 |
CDK17 |
0.476 | -0.032 | 1 | 0.156 |
CK1D |
0.476 | -0.041 | -3 | 0.229 |
CDK3 |
0.475 | -0.027 | 1 | 0.167 |
ULK1 |
0.474 | -0.059 | -3 | 0.298 |
NEK6 |
0.473 | -0.092 | -2 | 0.470 |
CK1G1 |
0.473 | 0.016 | -3 | 0.294 |
CK2A2 |
0.471 | -0.035 | 1 | 0.238 |
CK2A1 |
0.471 | -0.028 | 1 | 0.219 |
FAM20C |
0.471 | -0.018 | 2 | 0.286 |
CDK7 |
0.469 | -0.044 | 1 | 0.234 |
CDK8 |
0.469 | -0.059 | 1 | 0.231 |
CK1E |
0.468 | -0.045 | -3 | 0.269 |
CK1G2 |
0.464 | 0.009 | -3 | 0.246 |
CDK19 |
0.460 | -0.057 | 1 | 0.217 |
KIS |
0.438 | -0.073 | 1 | 0.272 |
CK1A |
0.437 | -0.050 | -3 | 0.205 |
PINK1_TYR |
0.424 | 0.117 | 1 | 0.330 |
MAP2K7_TYR |
0.422 | 0.042 | 2 | 0.452 |
MAP2K4_TYR |
0.421 | -0.011 | -1 | 0.400 |
BMPR2_TYR |
0.420 | 0.013 | -1 | 0.381 |
MAP2K6_TYR |
0.420 | 0.002 | -1 | 0.407 |
PDHK3_TYR |
0.420 | -0.022 | 4 | 0.526 |
PDHK4_TYR |
0.417 | -0.005 | 2 | 0.510 |
NEK10_TYR |
0.416 | 0.021 | 1 | 0.353 |
PDHK1_TYR |
0.416 | -0.045 | -1 | 0.407 |
PKMYT1_TYR |
0.414 | -0.035 | 3 | 0.534 |
TYK2 |
0.413 | 0.002 | 1 | 0.453 |
RET |
0.413 | 0.011 | 1 | 0.407 |
LIMK2_TYR |
0.413 | 0.022 | -3 | 0.462 |
TNNI3K_TYR |
0.411 | 0.049 | 1 | 0.430 |
TESK1_TYR |
0.411 | -0.075 | 3 | 0.571 |
FLT3 |
0.410 | 0.023 | 3 | 0.432 |
ITK |
0.408 | 0.021 | -1 | 0.331 |
LIMK1_TYR |
0.408 | -0.051 | 2 | 0.415 |
SRMS |
0.407 | -0.031 | 1 | 0.404 |
MST1R |
0.406 | -0.050 | 3 | 0.455 |
TNK1 |
0.406 | 0.059 | 3 | 0.419 |
YES1 |
0.406 | -0.037 | -1 | 0.372 |
WEE1_TYR |
0.405 | -0.015 | -1 | 0.354 |
JAK2 |
0.405 | -0.037 | 1 | 0.446 |
BTK |
0.404 | -0.045 | -1 | 0.322 |
TNK2 |
0.404 | -0.020 | 3 | 0.422 |
DDR1 |
0.403 | -0.057 | 4 | 0.477 |
FYN |
0.403 | -0.012 | -1 | 0.315 |
CSF1R |
0.402 | -0.044 | 3 | 0.425 |
BLK |
0.402 | -0.017 | -1 | 0.339 |
TXK |
0.402 | -0.033 | 1 | 0.337 |
FRK |
0.401 | -0.022 | -1 | 0.340 |
FER |
0.401 | -0.095 | 1 | 0.388 |
CSK |
0.401 | -0.017 | 2 | 0.430 |
EPHA4 |
0.401 | -0.042 | 2 | 0.459 |
FGR |
0.400 | -0.097 | 1 | 0.376 |
BMX |
0.400 | -0.012 | -1 | 0.276 |
JAK1 |
0.400 | -0.032 | 1 | 0.466 |
KIT |
0.400 | -0.035 | 3 | 0.433 |
TYRO3 |
0.400 | -0.100 | 3 | 0.435 |
ABL2 |
0.399 | -0.071 | -1 | 0.358 |
ABL1 |
0.399 | -0.084 | -1 | 0.362 |
EPHB1 |
0.399 | -0.057 | 1 | 0.432 |
EPHB4 |
0.398 | -0.098 | -1 | 0.334 |
LCK |
0.398 | -0.040 | -1 | 0.335 |
HCK |
0.398 | -0.086 | -1 | 0.334 |
PTK6 |
0.398 | -0.092 | -1 | 0.311 |
EPHB2 |
0.398 | -0.068 | -1 | 0.319 |
TEC |
0.398 | -0.033 | -1 | 0.301 |
ROS1 |
0.397 | -0.103 | 3 | 0.411 |
PDGFRB |
0.396 | -0.067 | 3 | 0.441 |
JAK3 |
0.396 | -0.083 | 1 | 0.337 |
FLT1 |
0.396 | -0.051 | -1 | 0.325 |
KDR |
0.395 | -0.053 | 3 | 0.396 |
EPHA6 |
0.395 | -0.083 | -1 | 0.359 |
MATK |
0.395 | -0.046 | -1 | 0.344 |
FGFR2 |
0.395 | -0.079 | 3 | 0.470 |
INSRR |
0.394 | -0.110 | 3 | 0.408 |
SYK |
0.394 | -0.035 | -1 | 0.268 |
LYN |
0.394 | -0.047 | 3 | 0.376 |
SRC |
0.393 | -0.052 | -1 | 0.322 |
ERBB2 |
0.393 | -0.078 | 1 | 0.356 |
NTRK1 |
0.392 | -0.110 | -1 | 0.347 |
EPHA7 |
0.392 | -0.055 | 2 | 0.447 |
AXL |
0.391 | -0.091 | 3 | 0.413 |
ALK |
0.391 | -0.083 | 3 | 0.378 |
FGFR4 |
0.391 | -0.037 | -1 | 0.299 |
MET |
0.391 | -0.074 | 3 | 0.426 |
LTK |
0.391 | -0.090 | 3 | 0.401 |
EPHA5 |
0.391 | -0.052 | 2 | 0.449 |
EPHB3 |
0.390 | -0.101 | -1 | 0.321 |
FLT4 |
0.390 | -0.070 | 3 | 0.424 |
PTK2 |
0.390 | -0.036 | -1 | 0.291 |
EPHA8 |
0.390 | -0.046 | -1 | 0.296 |
MERTK |
0.390 | -0.114 | 3 | 0.428 |
PDGFRA |
0.390 | -0.119 | 3 | 0.443 |
EGFR |
0.389 | -0.063 | 1 | 0.294 |
EPHA1 |
0.389 | -0.078 | 3 | 0.386 |
PTK2B |
0.388 | -0.080 | -1 | 0.376 |
EPHA3 |
0.388 | -0.093 | 2 | 0.419 |
FGFR3 |
0.387 | -0.083 | 3 | 0.435 |
TEK |
0.387 | -0.099 | 3 | 0.379 |
NTRK2 |
0.386 | -0.129 | 3 | 0.428 |
DDR2 |
0.386 | -0.039 | 3 | 0.410 |
FGFR1 |
0.385 | -0.119 | 3 | 0.410 |
INSR |
0.384 | -0.123 | 3 | 0.385 |
EPHA2 |
0.382 | -0.061 | -1 | 0.266 |
NTRK3 |
0.381 | -0.118 | -1 | 0.314 |
MUSK |
0.378 | -0.109 | 1 | 0.299 |
ERBB4 |
0.378 | -0.062 | 1 | 0.314 |
IGF1R |
0.376 | -0.095 | 3 | 0.342 |
FES |
0.373 | -0.100 | -1 | 0.279 |
ZAP70 |
0.368 | -0.059 | -1 | 0.264 |