Motif 125 (n=257)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A7KAX9 | ARHGAP32 | S1794 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
H7C1W4 | None | S343 | ochoa | Uncharacterized protein | None |
O14994 | SYN3 | S539 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
O15014 | ZNF609 | S1285 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
O15169 | AXIN1 | S215 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
O43182 | ARHGAP6 | S635 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
O43426 | SYNJ1 | S1223 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
O43493 | TGOLN2 | S349 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
O43524 | FOXO3 | S553 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
O60292 | SIPA1L3 | S1307 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60303 | KATNIP | S691 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
O60447 | EVI5 | S113 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
O60888 | CUTA | S46 | ochoa | Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) | May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE). |
O60907 | TBL1X | S474 | psp | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
O75420 | GIGYF1 | S860 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75420 | GIGYF1 | S863 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75717 | WDHD1 | S886 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
O75940 | SMNDC1 | S61 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
O75970 | MPDZ | S1818 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
O76039 | CDKL5 | S477 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
O94804 | STK10 | S369 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
O94885 | SASH1 | S329 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
O94916 | NFAT5 | S646 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
O95235 | KIF20A | S254 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95243 | MBD4 | S319 | ochoa | Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) | Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}. |
O95475 | SIX6 | S225 | ochoa | Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) | May be involved in eye development. |
O96017 | CHEK2 | S33 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
P01100 | FOS | S362 | ochoa|psp | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
P04049 | RAF1 | S497 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P07332 | FES | S70 | ochoa | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
P08172 | CHRM2 | S309 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
P08195 | SLC3A2 | S406 | psp | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
P08240 | SRPRA | S296 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
P0DJ93 | SMIM13 | S58 | ochoa | Small integral membrane protein 13 | None |
P13010 | XRCC5 | S577 | ochoa|psp | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
P15056 | BRAF | S605 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P15924 | DSP | S2551 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P19447 | ERCC3 | S231 | ochoa | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}. |
P20719 | HOXA5 | S121 | ochoa | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
P21802 | FGFR2 | S780 | psp | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
P30260 | CDC27 | S220 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
P30559 | OXTR | S366 | ochoa | Oxytocin receptor (OT-R) | Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
P30559 | OXTR | S368 | ochoa | Oxytocin receptor (OT-R) | Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
P31943 | HNRNPH1 | S21 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
P38432 | COIL | S235 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
P42574 | CASP3 | S24 | ochoa | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
P42695 | NCAPD3 | S1382 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
P45880 | VDAC2 | S46 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
P46108 | CRK | S41 | ochoa|psp | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
P46531 | NOTCH1 | S2522 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
P48553 | TRAPPC10 | S1201 | ochoa | Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) | Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. {ECO:0000269|PubMed:11805826, ECO:0000269|PubMed:31467083, ECO:0000269|PubMed:35298461}. |
P51531 | SMARCA2 | S698 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P51531 | SMARCA2 | S1408 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P51587 | BRCA2 | S1968 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
P54132 | BLM | S1379 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
P54920 | NAPA | S24 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
P55040 | GEM | S57 | ochoa | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. |
P55197 | MLLT10 | S404 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
P57078 | RIPK4 | S404 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
P98082 | DAB2 | S262 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
P98171 | ARHGAP4 | S408 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
Q01081 | U2AF1 | S59 | ochoa | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
Q02241 | KIF23 | S716 | ochoa|psp | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
Q03164 | KMT2A | S2283 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q04724 | TLE1 | S284 | ochoa | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}. |
Q07157 | TJP1 | S1577 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q09019 | DMWD | Y543 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
Q12800 | TFCP2 | S289 | psp | Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}. |
Q12948 | FOXC1 | S527 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
Q12955 | ANK3 | S911 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
Q12959 | DLG1 | S568 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
Q13422 | IKZF1 | S391 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
Q13546 | RIPK1 | S331 | ochoa | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
Q13627 | DYRK1A | S502 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
Q13796 | SHROOM2 | S193 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Q14123 | PDE1C | S486 | ochoa | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) | Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}. |
Q14157 | UBAP2L | S317 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
Q14202 | ZMYM3 | S1047 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Q14315 | FLNC | Y2625 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14573 | ITPR3 | S1832 | ochoa|psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
Q14669 | TRIP12 | S161 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
Q15022 | SUZ12 | S382 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
Q15052 | ARHGEF6 | S561 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
Q15345 | LRRC41 | S357 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
Q15648 | MED1 | S1227 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q15648 | MED1 | S1252 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q15648 | MED1 | S1532 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q15648 | MED1 | S1534 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q16473 | TNXA | S139 | ochoa | Putative tenascin-XA (TN-XA) | None |
Q16659 | MAPK6 | S556 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
Q16799 | RTN1 | S164 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
Q17R98 | ZNF827 | S961 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
Q2LD37 | BLTP1 | S1226 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q49A88 | CCDC14 | S124 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
Q4AC94 | C2CD3 | S299 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
Q5H9M0 | PWWP3B | S107 | ochoa | PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1) | None |
Q5QP82 | DCAF10 | S349 | ochoa | DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
Q5SR56 | MFSD14B | S466 | ochoa | Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B) | None |
Q5SW79 | CEP170 | S578 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5T481 | RBM20 | S740 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
Q5THJ4 | VPS13D | S2436 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q5TZA2 | CROCC | S462 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
Q5VT25 | CDC42BPA | S1609 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
Q5VVJ2 | MYSM1 | S265 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
Q5XUX1 | FBXW9 | S61 | ochoa | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
Q63ZY3 | KANK2 | S425 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q684P5 | RAP1GAP2 | S698 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
Q68CZ2 | TNS3 | S388 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
Q68DA7 | FMN1 | S396 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
Q6DCA0 | AMMECR1L | S27 | ochoa | AMMECR1-like protein | None |
Q6P444 | MTFR2 | S171 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
Q6P4F7 | ARHGAP11A | S886 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
Q6PJP8 | DCLRE1A | S238 | ochoa | DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}. |
Q6T4R5 | NHS | S991 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
Q6T4R5 | NHS | S1410 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
Q6T4R5 | NHS | S1477 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
Q6UXY1 | BAIAP2L2 | S299 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
Q6UXY8 | TMC5 | S84 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
Q70CQ4 | USP31 | S803 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
Q71F56 | MED13L | S1641 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
Q76N89 | HECW1 | S66 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
Q7L804 | RAB11FIP2 | S227 | ochoa|psp | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
Q7LBC6 | KDM3B | S1320 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
Q7Z3C6 | ATG9A | S675 | ochoa | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
Q7Z401 | DENND4A | S963 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q7Z402 | TMC7 | S87 | ochoa | Transmembrane channel-like protein 7 | Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}. |
Q7Z460 | CLASP1 | S254 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
Q7Z4S6 | KIF21A | S1307 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
Q7Z4V5 | HDGFL2 | S142 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
Q86SJ2 | AMIGO2 | S443 | ochoa | Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
Q86SQ0 | PHLDB2 | S173 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86TC9 | MYPN | S198 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
Q86TI0 | TBC1D1 | S525 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
Q86U06 | RBM23 | S41 | ochoa | Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) | RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}. |
Q86VP3 | PACS2 | S700 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
Q86X51 | EZHIP | S336 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
Q86XA9 | HEATR5A | S827 | ochoa | HEAT repeat-containing protein 5A | None |
Q86XP3 | DDX42 | S715 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
Q86XR8 | CEP57 | S53 | ochoa | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}. |
Q86XZ4 | SPATS2 | S208 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
Q8IU60 | DCP2 | S247 | ochoa | m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:28002401}. |
Q8IVL0 | NAV3 | S1670 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
Q8IVL1 | NAV2 | S1363 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
Q8IVL1 | NAV2 | S1611 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
Q8IVL1 | NAV2 | S1854 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
Q8IVT5 | KSR1 | S194 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
Q8IWB9 | TEX2 | S141 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
Q8IWQ3 | BRSK2 | S410 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
Q8IWS0 | PHF6 | S55 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
Q8IWU2 | LMTK2 | S1395 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
Q8N5A5 | ZGPAT | S276 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
Q8N9B5 | JMY | S854 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
Q8NCN4 | RNF169 | S292 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
Q8NEG4 | FAM83F | S480 | ochoa | Protein FAM83F | None |
Q8NEV8 | EXPH5 | S318 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
Q8NEY1 | NAV1 | S1182 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8TBA6 | GOLGA5 | S187 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
Q8TBE0 | BAHD1 | S543 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
Q8TDM6 | DLG5 | S886 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8TDN4 | CABLES1 | S418 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
Q8TF40 | FNIP1 | S97 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
Q8TF71 | SLC16A10 | S266 | ochoa | Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}. |
Q8WX93 | PALLD | S1333 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
Q8WXG6 | MADD | S1239 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
Q8WXI2 | CNKSR2 | S685 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
Q8WXI7 | MUC16 | S6336 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
Q8WYB5 | KAT6B | S522 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
Q92610 | ZNF592 | S346 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
Q93075 | TATDN2 | S400 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
Q96CP6 | GRAMD1A | S584 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
Q96D09 | GPRASP2 | S282 | ochoa | G-protein coupled receptor-associated sorting protein 2 (GASP-2) | May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}. |
Q96DY7 | MTBP | S756 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
Q96EB6 | SIRT1 | S659 | psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
Q96EN8 | MOCOS | S528 | ochoa | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) | Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608). {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608, ECO:0000269|PubMed:34356852}. |
Q96EV2 | RBM33 | S739 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
Q96HC4 | PDLIM5 | S134 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
Q96IZ7 | RSRC1 | S237 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
Q96JA1 | LRIG1 | S1033 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
Q96MK2 | RIPOR3 | S22 | ochoa | RIPOR family member 3 | None |
Q96MK2 | RIPOR3 | S397 | ochoa | RIPOR family member 3 | None |
Q96Q15 | SMG1 | S34 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
Q96QT4 | TRPM7 | S101 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
Q96SK2 | TMEM209 | S176 | ochoa | Transmembrane protein 209 | Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}. |
Q96SN8 | CDK5RAP2 | S841 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
Q96ST8 | CEP89 | S77 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
Q96T58 | SPEN | S749 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99570 | PIK3R4 | S892 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
Q99728 | BARD1 | S389 | ochoa | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
Q99767 | APBA2 | S236 | psp | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
Q99959 | PKP2 | S225 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
Q99963 | SH3GL3 | S263 | ochoa | Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
Q9BSC4 | NOL10 | S632 | ochoa | Nucleolar protein 10 | None |
Q9BVL2 | NUP58 | S540 | ochoa | Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}. |
Q9BX66 | SORBS1 | S280 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
Q9BXW9 | FANCD2 | S592 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
Q9BYI3 | HYCC1 | S431 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
Q9BYP7 | WNK3 | S1471 | ochoa | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
Q9BZB8 | CPEB1 | S178 | ochoa | Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) | Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}. |
Q9BZL4 | PPP1R12C | S336 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9C0A6 | SETD5 | S539 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
Q9C0D5 | TANC1 | S182 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Q9H2Y7 | ZNF106 | S1468 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H4H8 | FAM83D | S472 | ochoa | Protein FAM83D (Spindle protein CHICA) | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}. |
Q9H582 | ZNF644 | S637 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
Q9H6S0 | YTHDC2 | S1184 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
Q9H992 | MARCHF7 | S359 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
Q9H992 | MARCHF7 | S366 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
Q9HCS7 | XAB2 | S749 | ochoa | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
Q9NQG6 | MIEF1 | S92 | ochoa | Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}. |
Q9NRR5 | UBQLN4 | S133 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
Q9NSI8 | SAMSN1 | S123 | ochoa | SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}. |
Q9NV56 | MRGBP | S147 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
Q9NXV6 | CDKN2AIP | S209 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
Q9NXX6 | NSMCE4A | S61 | ochoa | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
Q9NYB9 | ABI2 | S242 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
Q9NZ09 | UBAP1 | S265 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
Q9NZB2 | FAM120A | S923 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
Q9P0U3 | SENP1 | S106 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
Q9P0U3 | SENP1 | S159 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
Q9P1T7 | MDFIC | S138 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
Q9P2R6 | RERE | S613 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
Q9P2R6 | RERE | S679 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
Q9UBF6 | RNF7 | S20 | ochoa | RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) | Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581). {ECO:0000250|UniProtKB:Q9WTZ1, ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:38574733}.; FUNCTION: [Isoform 2]: Inactive. {ECO:0000269|PubMed:11506706}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:23300442}. |
Q9UBL0 | ARPP21 | S395 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
Q9UBP0 | SPAST | S268 | ochoa|psp | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
Q9UDT6 | CLIP2 | S314 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
Q9UDT6 | CLIP2 | S317 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
Q9UHB7 | AFF4 | S118 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
Q9UHB7 | AFF4 | S836 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
Q9UHI6 | DDX20 | S500 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
Q9UHV7 | MED13 | S481 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
Q9UIJ5 | ZDHHC2 | S331 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
Q9UKX7 | NUP50 | S268 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
Q9ULD2 | MTUS1 | S199 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9ULE6 | PALD1 | S32 | ochoa | Paladin | None |
Q9ULJ7 | ANKRD50 | S1138 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
Q9ULL8 | SHROOM4 | S785 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
Q9ULT0 | TTC7A | S672 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
Q9UPR0 | PLCL2 | S123 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
Q9UPU9 | SAMD4A | S649 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
Q9UPZ3 | HPS5 | S461 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
Q9Y250 | LZTS1 | S231 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
Q9Y253 | POLH | S512 | ochoa|psp | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
Q9Y294 | ASF1A | S181 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
Q9Y2G3 | ATP11B | S1154 | ochoa | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}. |
Q9Y2H9 | MAST1 | S159 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
Q9Y2I7 | PIKFYVE | S491 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
Q9Y2L6 | FRMD4B | S776 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
Q9Y485 | DMXL1 | S1256 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
Q9Y4K4 | MAP4K5 | S434 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Q9Y6Q6 | TNFRSF11A | S511 | ochoa | Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). {ECO:0000250|UniProtKB:O35305, ECO:0000269|PubMed:9878548}. |
V9GY48 | None | S182 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein | None |
Q12968 | NFATC3 | S161 | Sugiyama | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
Q15751 | HERC1 | S3238 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
Q14C86 | GAPVD1 | S740 | Sugiyama | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
Q15118 | PDK1 | S27 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
Q9Y5K5 | UCHL5 | S131 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.000064 | 4.192 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 0.000107 | 3.969 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.000932 | 3.031 |
R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.000944 | 3.025 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.000524 | 3.281 |
R-HSA-109704 | PI3K Cascade | 0.000524 | 3.281 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.000741 | 3.130 |
R-HSA-112399 | IRS-mediated signalling | 0.000942 | 3.026 |
R-HSA-190241 | FGFR2 ligand binding and activation | 0.001090 | 2.963 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.001274 | 2.895 |
R-HSA-2428924 | IGF1R signaling cascade | 0.001578 | 2.802 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.001690 | 2.772 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.001578 | 2.802 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.002062 | 2.686 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.002579 | 2.589 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.002868 | 2.542 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.002996 | 2.524 |
R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 0.003385 | 2.470 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.003385 | 2.470 |
R-HSA-5654738 | Signaling by FGFR2 | 0.004211 | 2.376 |
R-HSA-205025 | NADE modulates death signalling | 0.004820 | 2.317 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.005044 | 2.297 |
R-HSA-191859 | snRNP Assembly | 0.006066 | 2.217 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.006066 | 2.217 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.006014 | 2.221 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.005533 | 2.257 |
R-HSA-447038 | NrCAM interactions | 0.006488 | 2.188 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.008235 | 2.084 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.009194 | 2.037 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.009194 | 2.037 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.009194 | 2.037 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.009194 | 2.037 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.007057 | 2.151 |
R-HSA-2033519 | Activated point mutants of FGFR2 | 0.007338 | 2.134 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.008381 | 2.077 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.009459 | 2.024 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.008381 | 2.077 |
R-HSA-74752 | Signaling by Insulin receptor | 0.008414 | 2.075 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.009572 | 2.019 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.010170 | 1.993 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.010170 | 1.993 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.010490 | 1.979 |
R-HSA-5683057 | MAPK family signaling cascades | 0.010709 | 1.970 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.012808 | 1.893 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.014058 | 1.852 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.014058 | 1.852 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.014058 | 1.852 |
R-HSA-6802949 | Signaling by RAS mutants | 0.014058 | 1.852 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.012808 | 1.893 |
R-HSA-73894 | DNA Repair | 0.013916 | 1.857 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.013662 | 1.864 |
R-HSA-190236 | Signaling by FGFR | 0.011378 | 1.944 |
R-HSA-162582 | Signal Transduction | 0.012917 | 1.889 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.012592 | 1.900 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.014108 | 1.851 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.015328 | 1.815 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.015328 | 1.815 |
R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.016811 | 1.774 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.016284 | 1.788 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.016370 | 1.786 |
R-HSA-170984 | ARMS-mediated activation | 0.018041 | 1.744 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.019827 | 1.703 |
R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.020941 | 1.679 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.022316 | 1.651 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.023990 | 1.620 |
R-HSA-190377 | FGFR2b ligand binding and activation | 0.024021 | 1.619 |
R-HSA-451306 | Ionotropic activity of kainate receptors | 0.024021 | 1.619 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.027273 | 1.564 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.025729 | 1.590 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.025729 | 1.590 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.029406 | 1.532 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.029406 | 1.532 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.027819 | 1.556 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.027535 | 1.560 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.029406 | 1.532 |
R-HSA-5693538 | Homology Directed Repair | 0.026189 | 1.582 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.027273 | 1.564 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.029406 | 1.532 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.026189 | 1.582 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.033340 | 1.477 |
R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.033340 | 1.477 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.033340 | 1.477 |
R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.033340 | 1.477 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.031344 | 1.504 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.030298 | 1.519 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.031344 | 1.504 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.031344 | 1.504 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.030692 | 1.513 |
R-HSA-5673000 | RAF activation | 0.033346 | 1.477 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.033346 | 1.477 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.033346 | 1.477 |
R-HSA-180746 | Nuclear import of Rev protein | 0.033346 | 1.477 |
R-HSA-190375 | FGFR2c ligand binding and activation | 0.034271 | 1.465 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.035414 | 1.451 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.036755 | 1.435 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.035414 | 1.451 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.034271 | 1.465 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.034271 | 1.465 |
R-HSA-199991 | Membrane Trafficking | 0.037732 | 1.423 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.038003 | 1.420 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.044326 | 1.353 |
R-HSA-72172 | mRNA Splicing | 0.038851 | 1.411 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.042003 | 1.377 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.039742 | 1.401 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.039754 | 1.401 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.044326 | 1.353 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.041882 | 1.378 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.042003 | 1.377 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.044326 | 1.353 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.045011 | 1.347 |
R-HSA-8853333 | Signaling by FGFR2 fusions | 0.049593 | 1.305 |
R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.081286 | 1.090 |
R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.096735 | 1.014 |
R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.096735 | 1.014 |
R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.096735 | 1.014 |
R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.096735 | 1.014 |
R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.096735 | 1.014 |
R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.126861 | 0.897 |
R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.126861 | 0.897 |
R-HSA-111957 | Cam-PDE 1 activation | 0.126861 | 0.897 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.126861 | 0.897 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 0.155986 | 0.807 |
R-HSA-2562578 | TRIF-mediated programmed cell death | 0.155986 | 0.807 |
R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.155986 | 0.807 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.155986 | 0.807 |
R-HSA-196025 | Formation of annular gap junctions | 0.170184 | 0.769 |
R-HSA-8875656 | MET receptor recycling | 0.170184 | 0.769 |
R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.184143 | 0.735 |
R-HSA-190873 | Gap junction degradation | 0.184143 | 0.735 |
R-HSA-5218900 | CASP8 activity is inhibited | 0.184143 | 0.735 |
R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.197869 | 0.704 |
R-HSA-164843 | 2-LTR circle formation | 0.197869 | 0.704 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.077539 | 1.110 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.077539 | 1.110 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.082494 | 1.084 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.211364 | 0.675 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.211364 | 0.675 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.211364 | 0.675 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.211364 | 0.675 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.224633 | 0.649 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.224633 | 0.649 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.046713 | 1.331 |
R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.237680 | 0.624 |
R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.237680 | 0.624 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.237680 | 0.624 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.237680 | 0.624 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.237680 | 0.624 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.237680 | 0.624 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.237680 | 0.624 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.108597 | 0.964 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.250508 | 0.601 |
R-HSA-69166 | Removal of the Flap Intermediate | 0.263121 | 0.580 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.275522 | 0.560 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.275522 | 0.560 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.287716 | 0.541 |
R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.287716 | 0.541 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.287716 | 0.541 |
R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.287716 | 0.541 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.050303 | 1.298 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.153964 | 0.813 |
R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.299705 | 0.523 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.096222 | 1.017 |
R-HSA-6782135 | Dual incision in TC-NER | 0.103053 | 0.987 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.311492 | 0.507 |
R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.311492 | 0.507 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.068390 | 1.165 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.120930 | 0.917 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.120930 | 0.917 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.132166 | 0.879 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.159690 | 0.797 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.233135 | 0.632 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.233135 | 0.632 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.167855 | 0.775 |
R-HSA-380287 | Centrosome maturation | 0.167855 | 0.775 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.270580 | 0.568 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.227915 | 0.642 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.320378 | 0.494 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.320378 | 0.494 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.320378 | 0.494 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.320378 | 0.494 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.320378 | 0.494 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.073890 | 1.131 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.171983 | 0.765 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.075073 | 1.125 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.215180 | 0.667 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.215180 | 0.667 |
R-HSA-69183 | Processive synthesis on the lagging strand | 0.275522 | 0.560 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.245597 | 0.610 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.318852 | 0.496 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.215180 | 0.667 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.147684 | 0.831 |
R-HSA-191650 | Regulation of gap junction activity | 0.096735 | 1.014 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.114052 | 0.943 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.299705 | 0.523 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.276827 | 0.558 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.237680 | 0.624 |
R-HSA-4641265 | Repression of WNT target genes | 0.237680 | 0.624 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.276827 | 0.558 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.065019 | 1.187 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.184143 | 0.735 |
R-HSA-165158 | Activation of AKT2 | 0.111925 | 0.951 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.170184 | 0.769 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.184143 | 0.735 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.119577 | 0.922 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.142289 | 0.847 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.311492 | 0.507 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.226918 | 0.644 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.065124 | 1.186 |
R-HSA-169893 | Prolonged ERK activation events | 0.045903 | 1.338 |
R-HSA-75893 | TNF signaling | 0.096222 | 1.017 |
R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.096735 | 1.014 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.211364 | 0.675 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.058192 | 1.235 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.169868 | 0.770 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.210312 | 0.677 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.054346 | 1.265 |
R-HSA-392517 | Rap1 signalling | 0.063286 | 1.199 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.136526 | 0.865 |
R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.287716 | 0.541 |
R-HSA-75153 | Apoptotic execution phase | 0.065124 | 1.186 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.103214 | 0.986 |
R-HSA-6794361 | Neurexins and neuroligins | 0.083149 | 1.080 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.110327 | 0.957 |
R-HSA-5205647 | Mitophagy | 0.153964 | 0.813 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.081286 | 1.090 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.096735 | 1.014 |
R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.126861 | 0.897 |
R-HSA-3371378 | Regulation by c-FLIP | 0.170184 | 0.769 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.058757 | 1.231 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.184143 | 0.735 |
R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.197869 | 0.704 |
R-HSA-4839744 | Signaling by APC mutants | 0.211364 | 0.675 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.224633 | 0.649 |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.250508 | 0.601 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.250508 | 0.601 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.062316 | 1.205 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.275522 | 0.560 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.275522 | 0.560 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.287716 | 0.541 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.299705 | 0.523 |
R-HSA-8875878 | MET promotes cell motility | 0.177820 | 0.750 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.196062 | 0.708 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.202195 | 0.694 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.102232 | 0.990 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.163757 | 0.786 |
R-HSA-73893 | DNA Damage Bypass | 0.251839 | 0.599 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.142289 | 0.847 |
R-HSA-170968 | Frs2-mediated activation | 0.250508 | 0.601 |
R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.155986 | 0.807 |
R-HSA-9620244 | Long-term potentiation | 0.097908 | 1.009 |
R-HSA-3295583 | TRP channels | 0.103214 | 0.986 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.229256 | 0.640 |
R-HSA-9824272 | Somitogenesis | 0.226918 | 0.644 |
R-HSA-6807004 | Negative regulation of MET activity | 0.067930 | 1.168 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.051672 | 1.287 |
R-HSA-187687 | Signalling to ERKs | 0.159870 | 0.796 |
R-HSA-390648 | Muscarinic acetylcholine receptors | 0.111925 | 0.951 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.184143 | 0.735 |
R-HSA-9761174 | Formation of intermediate mesoderm | 0.197869 | 0.704 |
R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.263121 | 0.580 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.275522 | 0.560 |
R-HSA-6811438 | Intra-Golgi traffic | 0.202195 | 0.694 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.133241 | 0.875 |
R-HSA-912446 | Meiotic recombination | 0.264332 | 0.578 |
R-HSA-157118 | Signaling by NOTCH | 0.280596 | 0.552 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.137998 | 0.860 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.110327 | 0.957 |
R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.081286 | 1.090 |
R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.111925 | 0.951 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.126861 | 0.897 |
R-HSA-69416 | Dimerization of procaspase-8 | 0.170184 | 0.769 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.211364 | 0.675 |
R-HSA-5689901 | Metalloprotease DUBs | 0.103214 | 0.986 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.114052 | 0.943 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.299705 | 0.523 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.299705 | 0.523 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.311492 | 0.507 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.113647 | 0.944 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.075073 | 1.125 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.132166 | 0.879 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.205960 | 0.686 |
R-HSA-9909396 | Circadian clock | 0.243882 | 0.613 |
R-HSA-9609690 | HCMV Early Events | 0.301719 | 0.520 |
R-HSA-9645723 | Diseases of programmed cell death | 0.227915 | 0.642 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.241294 | 0.617 |
R-HSA-180786 | Extension of Telomeres | 0.314186 | 0.503 |
R-HSA-73887 | Death Receptor Signaling | 0.074620 | 1.127 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.314186 | 0.503 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.202195 | 0.694 |
R-HSA-9843745 | Adipogenesis | 0.240246 | 0.619 |
R-HSA-68886 | M Phase | 0.084396 | 1.074 |
R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.126861 | 0.897 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.239362 | 0.621 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.251839 | 0.599 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.170472 | 0.768 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.141547 | 0.849 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.077371 | 1.111 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.196062 | 0.708 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.127339 | 0.895 |
R-HSA-5653656 | Vesicle-mediated transport | 0.171029 | 0.767 |
R-HSA-162587 | HIV Life Cycle | 0.079515 | 1.100 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.103214 | 0.986 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.300446 | 0.522 |
R-HSA-9675135 | Diseases of DNA repair | 0.065124 | 1.186 |
R-HSA-68875 | Mitotic Prophase | 0.194319 | 0.711 |
R-HSA-9609646 | HCMV Infection | 0.309724 | 0.509 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.124430 | 0.905 |
R-HSA-6806834 | Signaling by MET | 0.064115 | 1.193 |
R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.065573 | 1.183 |
R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.081286 | 1.090 |
R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.111925 | 0.951 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.155986 | 0.807 |
R-HSA-444257 | RSK activation | 0.170184 | 0.769 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.184143 | 0.735 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.197869 | 0.704 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.077539 | 1.110 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.097908 | 1.009 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.046713 | 1.331 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.046713 | 1.331 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.049162 | 1.308 |
R-HSA-69091 | Polymerase switching | 0.237680 | 0.624 |
R-HSA-69109 | Leading Strand Synthesis | 0.237680 | 0.624 |
R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.250508 | 0.601 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.275522 | 0.560 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.275522 | 0.560 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.287716 | 0.541 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.183872 | 0.735 |
R-HSA-177929 | Signaling by EGFR | 0.096222 | 1.017 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.097908 | 1.009 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.125167 | 0.903 |
R-HSA-162906 | HIV Infection | 0.243784 | 0.613 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.184143 | 0.735 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.243882 | 0.613 |
R-HSA-2559583 | Cellular Senescence | 0.250221 | 0.602 |
R-HSA-1640170 | Cell Cycle | 0.073044 | 1.136 |
R-HSA-162592 | Integration of provirus | 0.224633 | 0.649 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.148103 | 0.829 |
R-HSA-983189 | Kinesins | 0.110071 | 0.958 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.127951 | 0.893 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.188772 | 0.724 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.126861 | 0.897 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.237680 | 0.624 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.237680 | 0.624 |
R-HSA-9005895 | Pervasive developmental disorders | 0.237680 | 0.624 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.250508 | 0.601 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.065124 | 1.186 |
R-HSA-399956 | CRMPs in Sema3A signaling | 0.263121 | 0.580 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.263121 | 0.580 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.275522 | 0.560 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.287716 | 0.541 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.311492 | 0.507 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.155655 | 0.808 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.314186 | 0.503 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.300446 | 0.522 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.275522 | 0.560 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.196062 | 0.708 |
R-HSA-9007101 | Rab regulation of trafficking | 0.184138 | 0.735 |
R-HSA-5688426 | Deubiquitination | 0.188710 | 0.724 |
R-HSA-1483255 | PI Metabolism | 0.300446 | 0.522 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.087544 | 1.058 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.263121 | 0.580 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.275522 | 0.560 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.299705 | 0.523 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.283071 | 0.548 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.241013 | 0.618 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.196062 | 0.708 |
R-HSA-4839726 | Chromatin organization | 0.175179 | 0.757 |
R-HSA-5617833 | Cilium Assembly | 0.282175 | 0.549 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.246318 | 0.609 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.225835 | 0.646 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.161118 | 0.793 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.099613 | 1.002 |
R-HSA-438064 | Post NMDA receptor activation events | 0.223487 | 0.651 |
R-HSA-8939211 | ESR-mediated signaling | 0.149462 | 0.825 |
R-HSA-388479 | Vasopressin-like receptors | 0.096735 | 1.014 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.275522 | 0.560 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.110071 | 0.958 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.117268 | 0.931 |
R-HSA-1489509 | DAG and IP3 signaling | 0.226918 | 0.644 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.204670 | 0.689 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.143330 | 0.844 |
R-HSA-3371556 | Cellular response to heat stress | 0.197751 | 0.704 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.289310 | 0.539 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.062757 | 1.202 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.222330 | 0.653 |
R-HSA-212436 | Generic Transcription Pathway | 0.275737 | 0.560 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.070315 | 1.153 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.155986 | 0.807 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 0.058757 | 1.231 |
R-HSA-2672351 | Stimuli-sensing channels | 0.148473 | 0.828 |
R-HSA-9707616 | Heme signaling | 0.117268 | 0.931 |
R-HSA-983712 | Ion channel transport | 0.278941 | 0.554 |
R-HSA-9686114 | Non-canonical inflammasome activation | 0.263121 | 0.580 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.287716 | 0.541 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.159690 | 0.797 |
R-HSA-194138 | Signaling by VEGF | 0.091695 | 1.038 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.164942 | 0.783 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.125167 | 0.903 |
R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.311492 | 0.507 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.272966 | 0.564 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.110546 | 0.956 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.110546 | 0.956 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.147684 | 0.831 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.262240 | 0.581 |
R-HSA-5683826 | Surfactant metabolism | 0.220713 | 0.656 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.186792 | 0.729 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.205444 | 0.687 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.288059 | 0.541 |
R-HSA-2028269 | Signaling by Hippo | 0.054346 | 1.265 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.103214 | 0.986 |
R-HSA-9842663 | Signaling by LTK | 0.237680 | 0.624 |
R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.311492 | 0.507 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.233013 | 0.633 |
R-HSA-166520 | Signaling by NTRKs | 0.311019 | 0.507 |
R-HSA-70171 | Glycolysis | 0.291263 | 0.536 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.288354 | 0.540 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.224633 | 0.649 |
R-HSA-354192 | Integrin signaling | 0.142289 | 0.847 |
R-HSA-9031628 | NGF-stimulated transcription | 0.245597 | 0.610 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.160846 | 0.794 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.103214 | 0.986 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.219077 | 0.659 |
R-HSA-2262752 | Cellular responses to stress | 0.311229 | 0.507 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.226918 | 0.644 |
R-HSA-446728 | Cell junction organization | 0.136923 | 0.864 |
R-HSA-418990 | Adherens junctions interactions | 0.219208 | 0.659 |
R-HSA-421270 | Cell-cell junction organization | 0.312667 | 0.505 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.165816 | 0.780 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.205704 | 0.687 |
R-HSA-1500931 | Cell-Cell communication | 0.213580 | 0.670 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.167855 | 0.775 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.245597 | 0.610 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.183872 | 0.735 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.153964 | 0.813 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.177995 | 0.750 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.079704 | 1.099 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.286679 | 0.543 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.241294 | 0.617 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.094424 | 1.025 |
R-HSA-9833110 | RSV-host interactions | 0.314247 | 0.503 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.128019 | 0.893 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.323083 | 0.491 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.323083 | 0.491 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.323083 | 0.491 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.323083 | 0.491 |
R-HSA-111471 | Apoptotic factor-mediated response | 0.323083 | 0.491 |
R-HSA-5358508 | Mismatch Repair | 0.323083 | 0.491 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.323083 | 0.491 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.326557 | 0.486 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.326557 | 0.486 |
R-HSA-112043 | PLC beta mediated events | 0.326557 | 0.486 |
R-HSA-211000 | Gene Silencing by RNA | 0.328063 | 0.484 |
R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.334478 | 0.476 |
R-HSA-110320 | Translesion Synthesis by POLH | 0.334478 | 0.476 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.334478 | 0.476 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.334478 | 0.476 |
R-HSA-912631 | Regulation of signaling by CBL | 0.334478 | 0.476 |
R-HSA-449836 | Other interleukin signaling | 0.334478 | 0.476 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.334478 | 0.476 |
R-HSA-1989781 | PPARA activates gene expression | 0.337662 | 0.472 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.338868 | 0.470 |
R-HSA-9612973 | Autophagy | 0.341478 | 0.467 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.345296 | 0.462 |
R-HSA-9610379 | HCMV Late Events | 0.345296 | 0.462 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.345683 | 0.461 |
R-HSA-1181150 | Signaling by NODAL | 0.345683 | 0.461 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.355462 | 0.449 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.355667 | 0.449 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.356700 | 0.448 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.356700 | 0.448 |
R-HSA-69186 | Lagging Strand Synthesis | 0.356700 | 0.448 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.356700 | 0.448 |
R-HSA-210991 | Basigin interactions | 0.356700 | 0.448 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 0.356700 | 0.448 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.363274 | 0.440 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.363274 | 0.440 |
R-HSA-112040 | G-protein mediated events | 0.363274 | 0.440 |
R-HSA-109581 | Apoptosis | 0.364391 | 0.438 |
R-HSA-74160 | Gene expression (Transcription) | 0.365157 | 0.438 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.367532 | 0.435 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.367532 | 0.435 |
R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.367532 | 0.435 |
R-HSA-947581 | Molybdenum cofactor biosynthesis | 0.367532 | 0.435 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.367532 | 0.435 |
R-HSA-175474 | Assembly Of The HIV Virion | 0.367532 | 0.435 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 0.367532 | 0.435 |
R-HSA-5218859 | Regulated Necrosis | 0.369323 | 0.433 |
R-HSA-68882 | Mitotic Anaphase | 0.371355 | 0.430 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.374692 | 0.426 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.378182 | 0.422 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.378182 | 0.422 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.378182 | 0.422 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.378182 | 0.422 |
R-HSA-373760 | L1CAM interactions | 0.378562 | 0.422 |
R-HSA-8953854 | Metabolism of RNA | 0.380665 | 0.419 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.381354 | 0.419 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.381354 | 0.419 |
R-HSA-70326 | Glucose metabolism | 0.383123 | 0.417 |
R-HSA-5619102 | SLC transporter disorders | 0.383464 | 0.416 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.387334 | 0.412 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.388653 | 0.410 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.388653 | 0.410 |
R-HSA-977068 | Termination of O-glycan biosynthesis | 0.388653 | 0.410 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.388653 | 0.410 |
R-HSA-9830674 | Formation of the ureteric bud | 0.388653 | 0.410 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.393287 | 0.405 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.393287 | 0.405 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.398949 | 0.399 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.398949 | 0.399 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.398949 | 0.399 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.398949 | 0.399 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.398949 | 0.399 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.405115 | 0.392 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.405265 | 0.392 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.409072 | 0.388 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.409072 | 0.388 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.409072 | 0.388 |
R-HSA-3214842 | HDMs demethylate histones | 0.409072 | 0.388 |
R-HSA-5689880 | Ub-specific processing proteases | 0.410049 | 0.387 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.413830 | 0.383 |
R-HSA-162909 | Host Interactions of HIV factors | 0.414810 | 0.382 |
R-HSA-5689603 | UCH proteinases | 0.416832 | 0.380 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.417606 | 0.379 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.419025 | 0.378 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.419025 | 0.378 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.419025 | 0.378 |
R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.419025 | 0.378 |
R-HSA-8953897 | Cellular responses to stimuli | 0.419441 | 0.377 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.428811 | 0.368 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.428811 | 0.368 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.428811 | 0.368 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.428811 | 0.368 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.428811 | 0.368 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.428811 | 0.368 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.428811 | 0.368 |
R-HSA-69481 | G2/M Checkpoints | 0.432688 | 0.364 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.434187 | 0.362 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.438433 | 0.358 |
R-HSA-5620971 | Pyroptosis | 0.438433 | 0.358 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.438433 | 0.358 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.438433 | 0.358 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.438433 | 0.358 |
R-HSA-9638334 | Iron assimilation using enterobactin | 0.438433 | 0.358 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.439911 | 0.357 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.445602 | 0.351 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.445602 | 0.351 |
R-HSA-72086 | mRNA Capping | 0.447893 | 0.349 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.447893 | 0.349 |
R-HSA-9615710 | Late endosomal microautophagy | 0.447893 | 0.349 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.447893 | 0.349 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.447893 | 0.349 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.447893 | 0.349 |
R-HSA-418360 | Platelet calcium homeostasis | 0.447893 | 0.349 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.447893 | 0.349 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.451262 | 0.346 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.456889 | 0.340 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.457195 | 0.340 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.462482 | 0.335 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.466340 | 0.331 |
R-HSA-182971 | EGFR downregulation | 0.466340 | 0.331 |
R-HSA-399719 | Trafficking of AMPA receptors | 0.466340 | 0.331 |
R-HSA-186763 | Downstream signal transduction | 0.466340 | 0.331 |
R-HSA-1500620 | Meiosis | 0.468042 | 0.330 |
R-HSA-69190 | DNA strand elongation | 0.475332 | 0.323 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.475332 | 0.323 |
R-HSA-1538133 | G0 and Early G1 | 0.475332 | 0.323 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.480733 | 0.318 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.484173 | 0.315 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.484173 | 0.315 |
R-HSA-9930044 | Nuclear RNA decay | 0.484173 | 0.315 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.484173 | 0.315 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.484173 | 0.315 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.484173 | 0.315 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.484173 | 0.315 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.484173 | 0.315 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.485018 | 0.314 |
R-HSA-9663891 | Selective autophagy | 0.489934 | 0.310 |
R-HSA-390522 | Striated Muscle Contraction | 0.492865 | 0.307 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.492865 | 0.307 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.492865 | 0.307 |
R-HSA-9664417 | Leishmania phagocytosis | 0.497744 | 0.303 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.497744 | 0.303 |
R-HSA-9664407 | Parasite infection | 0.497744 | 0.303 |
R-HSA-73884 | Base Excision Repair | 0.500667 | 0.300 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.501412 | 0.300 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.501412 | 0.300 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.501412 | 0.300 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.501951 | 0.299 |
R-HSA-1632852 | Macroautophagy | 0.501951 | 0.299 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.508945 | 0.293 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.509815 | 0.293 |
R-HSA-381042 | PERK regulates gene expression | 0.509815 | 0.293 |
R-HSA-9679506 | SARS-CoV Infections | 0.514146 | 0.289 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.518076 | 0.286 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.518076 | 0.286 |
R-HSA-111933 | Calmodulin induced events | 0.518076 | 0.286 |
R-HSA-111997 | CaM pathway | 0.518076 | 0.286 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.520142 | 0.284 |
R-HSA-4641257 | Degradation of AXIN | 0.526200 | 0.279 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.526200 | 0.279 |
R-HSA-4641258 | Degradation of DVL | 0.526200 | 0.279 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.526200 | 0.279 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.526200 | 0.279 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.529222 | 0.276 |
R-HSA-5357801 | Programmed Cell Death | 0.530648 | 0.275 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.530883 | 0.275 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.534186 | 0.272 |
R-HSA-69242 | S Phase | 0.534940 | 0.272 |
R-HSA-9758941 | Gastrulation | 0.538977 | 0.268 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.542039 | 0.266 |
R-HSA-69541 | Stabilization of p53 | 0.542039 | 0.266 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.542039 | 0.266 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.542121 | 0.266 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.542994 | 0.265 |
R-HSA-157579 | Telomere Maintenance | 0.547133 | 0.262 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.547133 | 0.262 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.549759 | 0.260 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.549759 | 0.260 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.549759 | 0.260 |
R-HSA-167169 | HIV Transcription Elongation | 0.549759 | 0.260 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.549759 | 0.260 |
R-HSA-71240 | Tryptophan catabolism | 0.549759 | 0.260 |
R-HSA-9614085 | FOXO-mediated transcription | 0.557041 | 0.254 |
R-HSA-3214847 | HATs acetylate histones | 0.557041 | 0.254 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.557350 | 0.254 |
R-HSA-9607240 | FLT3 Signaling | 0.557350 | 0.254 |
R-HSA-9694548 | Maturation of spike protein | 0.557350 | 0.254 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.557350 | 0.254 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.558343 | 0.253 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.558857 | 0.253 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.561937 | 0.250 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.562771 | 0.250 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.564814 | 0.248 |
R-HSA-167161 | HIV Transcription Initiation | 0.564814 | 0.248 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.564814 | 0.248 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.564814 | 0.248 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.572152 | 0.242 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.572152 | 0.242 |
R-HSA-73928 | Depyrimidination | 0.572152 | 0.242 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.572152 | 0.242 |
R-HSA-111996 | Ca-dependent events | 0.572152 | 0.242 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.572152 | 0.242 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.579367 | 0.237 |
R-HSA-9710421 | Defective pyroptosis | 0.579367 | 0.237 |
R-HSA-5654743 | Signaling by FGFR4 | 0.579367 | 0.237 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.579367 | 0.237 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.579367 | 0.237 |
R-HSA-111885 | Opioid Signalling | 0.581135 | 0.236 |
R-HSA-8951664 | Neddylation | 0.584668 | 0.233 |
R-HSA-190828 | Gap junction trafficking | 0.586460 | 0.232 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.586460 | 0.232 |
R-HSA-375280 | Amine ligand-binding receptors | 0.586460 | 0.232 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.590500 | 0.229 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.593434 | 0.227 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.593434 | 0.227 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.593434 | 0.227 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.593434 | 0.227 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.593434 | 0.227 |
R-HSA-5654741 | Signaling by FGFR3 | 0.593434 | 0.227 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.595124 | 0.225 |
R-HSA-69239 | Synthesis of DNA | 0.599709 | 0.222 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.599709 | 0.222 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.599709 | 0.222 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.600292 | 0.222 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.600292 | 0.222 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.600292 | 0.222 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.604255 | 0.219 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.607034 | 0.217 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.613230 | 0.212 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.613230 | 0.212 |
R-HSA-389356 | Co-stimulation by CD28 | 0.613662 | 0.212 |
R-HSA-9766229 | Degradation of CDH1 | 0.620179 | 0.207 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.620179 | 0.207 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.620179 | 0.207 |
R-HSA-72306 | tRNA processing | 0.622451 | 0.206 |
R-HSA-195721 | Signaling by WNT | 0.627502 | 0.202 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.629509 | 0.201 |
R-HSA-72187 | mRNA 3'-end processing | 0.639081 | 0.194 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.639081 | 0.194 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.639081 | 0.194 |
R-HSA-1280218 | Adaptive Immune System | 0.639113 | 0.194 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.639221 | 0.194 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.639926 | 0.194 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.643417 | 0.192 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.645171 | 0.190 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.645171 | 0.190 |
R-HSA-445355 | Smooth Muscle Contraction | 0.645171 | 0.190 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.645171 | 0.190 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.651158 | 0.186 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.651158 | 0.186 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.651695 | 0.186 |
R-HSA-168255 | Influenza Infection | 0.653494 | 0.185 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.657045 | 0.182 |
R-HSA-3214815 | HDACs deacetylate histones | 0.657045 | 0.182 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.662833 | 0.179 |
R-HSA-5578775 | Ion homeostasis | 0.662833 | 0.179 |
R-HSA-193648 | NRAGE signals death through JNK | 0.662833 | 0.179 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.662833 | 0.179 |
R-HSA-5654736 | Signaling by FGFR1 | 0.662833 | 0.179 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.664298 | 0.178 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.666694 | 0.176 |
R-HSA-73886 | Chromosome Maintenance | 0.667791 | 0.175 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.667791 | 0.175 |
R-HSA-9824446 | Viral Infection Pathways | 0.668049 | 0.175 |
R-HSA-5621480 | Dectin-2 family | 0.668524 | 0.175 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.668524 | 0.175 |
R-HSA-1643685 | Disease | 0.671303 | 0.173 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.674118 | 0.171 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.674118 | 0.171 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.674118 | 0.171 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.675612 | 0.170 |
R-HSA-2132295 | MHC class II antigen presentation | 0.675612 | 0.170 |
R-HSA-69275 | G2/M Transition | 0.676353 | 0.170 |
R-HSA-6809371 | Formation of the cornified envelope | 0.679467 | 0.168 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.679619 | 0.168 |
R-HSA-186712 | Regulation of beta-cell development | 0.679619 | 0.168 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.682676 | 0.166 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.685027 | 0.164 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.685027 | 0.164 |
R-HSA-5362517 | Signaling by Retinoic Acid | 0.685027 | 0.164 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.689321 | 0.162 |
R-HSA-450294 | MAP kinase activation | 0.690345 | 0.161 |
R-HSA-445717 | Aquaporin-mediated transport | 0.690345 | 0.161 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.691990 | 0.160 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.695572 | 0.158 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.695572 | 0.158 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.695572 | 0.158 |
R-HSA-186797 | Signaling by PDGF | 0.695572 | 0.158 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.695572 | 0.158 |
R-HSA-68877 | Mitotic Prometaphase | 0.698084 | 0.156 |
R-HSA-373755 | Semaphorin interactions | 0.700712 | 0.154 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.700712 | 0.154 |
R-HSA-8848021 | Signaling by PTK6 | 0.700712 | 0.154 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.700712 | 0.154 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.705766 | 0.151 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.705766 | 0.151 |
R-HSA-1474165 | Reproduction | 0.708972 | 0.149 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.718696 | 0.143 |
R-HSA-9830369 | Kidney development | 0.720422 | 0.142 |
R-HSA-9711123 | Cellular response to chemical stress | 0.720598 | 0.142 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.724382 | 0.140 |
R-HSA-913709 | O-linked glycosylation of mucins | 0.725143 | 0.140 |
R-HSA-167172 | Transcription of the HIV genome | 0.725143 | 0.140 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.725143 | 0.140 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.734350 | 0.134 |
R-HSA-448424 | Interleukin-17 signaling | 0.734350 | 0.134 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.734350 | 0.134 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.738837 | 0.131 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.738837 | 0.131 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.738837 | 0.131 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.738837 | 0.131 |
R-HSA-9638482 | Metal ion assimilation from the host | 0.738837 | 0.131 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.743249 | 0.129 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.743249 | 0.129 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.747587 | 0.126 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.747587 | 0.126 |
R-HSA-4086398 | Ca2+ pathway | 0.747587 | 0.126 |
R-HSA-9658195 | Leishmania infection | 0.751799 | 0.124 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.751799 | 0.124 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.751851 | 0.124 |
R-HSA-397014 | Muscle contraction | 0.754064 | 0.123 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.754064 | 0.123 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.756044 | 0.121 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.756631 | 0.121 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.760166 | 0.119 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.764219 | 0.117 |
R-HSA-9694635 | Translation of Structural Proteins | 0.764219 | 0.117 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.767124 | 0.115 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.768204 | 0.115 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.768204 | 0.115 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.768204 | 0.115 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.772922 | 0.112 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.775973 | 0.110 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.781383 | 0.107 |
R-HSA-69306 | DNA Replication | 0.786870 | 0.104 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.787142 | 0.104 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.790741 | 0.102 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.797757 | 0.098 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.797757 | 0.098 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.800061 | 0.097 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.804539 | 0.094 |
R-HSA-70268 | Pyruvate metabolism | 0.804539 | 0.094 |
R-HSA-202424 | Downstream TCR signaling | 0.814289 | 0.089 |
R-HSA-112310 | Neurotransmitter release cycle | 0.814289 | 0.089 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.814933 | 0.089 |
R-HSA-391251 | Protein folding | 0.823554 | 0.084 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.823554 | 0.084 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.826539 | 0.083 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.826539 | 0.083 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.829474 | 0.081 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.832359 | 0.080 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.834460 | 0.079 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.837985 | 0.077 |
R-HSA-112316 | Neuronal System | 0.838062 | 0.077 |
R-HSA-597592 | Post-translational protein modification | 0.838066 | 0.077 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.840726 | 0.075 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.843422 | 0.074 |
R-HSA-422356 | Regulation of insulin secretion | 0.843422 | 0.074 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.843422 | 0.074 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.843422 | 0.074 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.843422 | 0.074 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.853757 | 0.069 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.856232 | 0.067 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.858666 | 0.066 |
R-HSA-3781865 | Diseases of glycosylation | 0.859503 | 0.066 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.861059 | 0.065 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.861059 | 0.065 |
R-HSA-5663205 | Infectious disease | 0.862302 | 0.064 |
R-HSA-418346 | Platelet homeostasis | 0.865725 | 0.063 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.867998 | 0.061 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.870234 | 0.060 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.872432 | 0.059 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.872432 | 0.059 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.872432 | 0.059 |
R-HSA-202403 | TCR signaling | 0.874592 | 0.058 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.878805 | 0.056 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.878805 | 0.056 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.878805 | 0.056 |
R-HSA-109582 | Hemostasis | 0.879146 | 0.056 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.880858 | 0.055 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.882876 | 0.054 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.884861 | 0.053 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.888729 | 0.051 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.896083 | 0.048 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.896083 | 0.048 |
R-HSA-6805567 | Keratinization | 0.896918 | 0.047 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.899576 | 0.046 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.901278 | 0.045 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.901278 | 0.045 |
R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.902952 | 0.044 |
R-HSA-1483257 | Phospholipid metabolism | 0.903477 | 0.044 |
R-HSA-69206 | G1/S Transition | 0.907805 | 0.042 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.909368 | 0.041 |
R-HSA-114608 | Platelet degranulation | 0.910905 | 0.041 |
R-HSA-913531 | Interferon Signaling | 0.912776 | 0.040 |
R-HSA-5576891 | Cardiac conduction | 0.918209 | 0.037 |
R-HSA-9717189 | Sensory perception of taste | 0.918209 | 0.037 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.919597 | 0.036 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.920961 | 0.036 |
R-HSA-168249 | Innate Immune System | 0.923591 | 0.035 |
R-HSA-163685 | Integration of energy metabolism | 0.926190 | 0.033 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.926190 | 0.033 |
R-HSA-5173105 | O-linked glycosylation | 0.927443 | 0.033 |
R-HSA-5368287 | Mitochondrial translation | 0.928674 | 0.032 |
R-HSA-6807070 | PTEN Regulation | 0.929885 | 0.032 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.936731 | 0.028 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.942910 | 0.026 |
R-HSA-9711097 | Cellular response to starvation | 0.950224 | 0.022 |
R-HSA-877300 | Interferon gamma signaling | 0.951070 | 0.022 |
R-HSA-9006936 | Signaling by TGFB family members | 0.951901 | 0.021 |
R-HSA-9734767 | Developmental Cell Lineages | 0.953499 | 0.021 |
R-HSA-416476 | G alpha (q) signalling events | 0.954158 | 0.020 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.962168 | 0.017 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.962168 | 0.017 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.962518 | 0.017 |
R-HSA-6798695 | Neutrophil degranulation | 0.962519 | 0.017 |
R-HSA-449147 | Signaling by Interleukins | 0.964120 | 0.016 |
R-HSA-422475 | Axon guidance | 0.964452 | 0.016 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.969735 | 0.013 |
R-HSA-1266738 | Developmental Biology | 0.970417 | 0.013 |
R-HSA-9675108 | Nervous system development | 0.976599 | 0.010 |
R-HSA-418594 | G alpha (i) signalling events | 0.976878 | 0.010 |
R-HSA-376176 | Signaling by ROBO receptors | 0.977401 | 0.010 |
R-HSA-9640148 | Infection with Enterobacteria | 0.977401 | 0.010 |
R-HSA-8957322 | Metabolism of steroids | 0.980843 | 0.008 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.981063 | 0.008 |
R-HSA-168256 | Immune System | 0.982977 | 0.007 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.986040 | 0.006 |
R-HSA-392499 | Metabolism of proteins | 0.987166 | 0.006 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.987626 | 0.005 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.987877 | 0.005 |
R-HSA-382551 | Transport of small molecules | 0.989266 | 0.005 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.992989 | 0.003 |
R-HSA-388396 | GPCR downstream signalling | 0.993211 | 0.003 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.993403 | 0.003 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.993698 | 0.003 |
R-HSA-5668914 | Diseases of metabolism | 0.996020 | 0.002 |
R-HSA-72766 | Translation | 0.996141 | 0.002 |
R-HSA-372790 | Signaling by GPCR | 0.997510 | 0.001 |
R-HSA-1474244 | Extracellular matrix organization | 0.997562 | 0.001 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997950 | 0.001 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.998625 | 0.001 |
R-HSA-500792 | GPCR ligand binding | 0.999690 | 0.000 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999984 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999998 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | -0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.826 | 0.168 | 2 | 0.278 |
CLK3 |
0.825 | 0.237 | 1 | 0.823 |
NDR2 |
0.820 | 0.101 | -3 | 0.868 |
PIM3 |
0.820 | 0.152 | -3 | 0.872 |
MOS |
0.814 | 0.149 | 1 | 0.889 |
CDC7 |
0.814 | 0.042 | 1 | 0.868 |
SKMLCK |
0.814 | 0.184 | -2 | 0.898 |
CLK2 |
0.812 | 0.276 | -3 | 0.812 |
PIM1 |
0.811 | 0.142 | -3 | 0.842 |
NDR1 |
0.810 | 0.081 | -3 | 0.869 |
CAMK1B |
0.810 | 0.125 | -3 | 0.890 |
RSK2 |
0.809 | 0.121 | -3 | 0.836 |
FAM20C |
0.809 | 0.019 | 2 | 0.228 |
PRKD1 |
0.808 | 0.073 | -3 | 0.870 |
CDKL1 |
0.805 | 0.098 | -3 | 0.857 |
P90RSK |
0.805 | 0.100 | -3 | 0.839 |
MTOR |
0.805 | 0.093 | 1 | 0.764 |
RAF1 |
0.804 | 0.104 | 1 | 0.810 |
PRKD2 |
0.803 | 0.081 | -3 | 0.836 |
SRPK1 |
0.803 | 0.113 | -3 | 0.821 |
HUNK |
0.803 | 0.092 | 2 | 0.285 |
CAMK2A |
0.803 | 0.123 | 2 | 0.291 |
RSK4 |
0.802 | 0.130 | -3 | 0.811 |
NUAK2 |
0.802 | 0.100 | -3 | 0.884 |
CAMK2B |
0.802 | 0.090 | 2 | 0.267 |
DYRK4 |
0.802 | 0.207 | 1 | 0.644 |
PKN3 |
0.802 | 0.035 | -3 | 0.868 |
CAMK2G |
0.802 | -0.005 | 2 | 0.248 |
CDKL5 |
0.802 | 0.070 | -3 | 0.859 |
HIPK4 |
0.801 | 0.058 | 1 | 0.782 |
PRPK |
0.801 | -0.051 | -1 | 0.838 |
RSK3 |
0.800 | 0.076 | -3 | 0.823 |
LATS2 |
0.799 | 0.026 | -5 | 0.767 |
PKN2 |
0.799 | 0.073 | -3 | 0.871 |
MSK1 |
0.799 | 0.142 | -3 | 0.812 |
DYRK2 |
0.799 | 0.129 | 1 | 0.707 |
RIPK3 |
0.799 | 0.066 | 3 | 0.770 |
P70S6KB |
0.798 | 0.077 | -3 | 0.848 |
GRK1 |
0.798 | 0.078 | -2 | 0.835 |
IKKB |
0.798 | 0.006 | -2 | 0.761 |
NLK |
0.798 | -0.002 | 1 | 0.821 |
DSTYK |
0.798 | 0.046 | 2 | 0.286 |
CAMLCK |
0.798 | 0.085 | -2 | 0.883 |
MARK4 |
0.798 | 0.039 | 4 | 0.842 |
ERK5 |
0.798 | 0.021 | 1 | 0.828 |
DAPK2 |
0.798 | 0.101 | -3 | 0.891 |
AMPKA1 |
0.798 | 0.026 | -3 | 0.886 |
AURC |
0.797 | 0.067 | -2 | 0.702 |
ICK |
0.797 | 0.071 | -3 | 0.885 |
MST4 |
0.797 | 0.003 | 2 | 0.212 |
PKACG |
0.797 | 0.058 | -2 | 0.794 |
GCN2 |
0.796 | -0.128 | 2 | 0.195 |
CAMK2D |
0.796 | 0.028 | -3 | 0.873 |
ATR |
0.796 | 0.013 | 1 | 0.821 |
MAPKAPK2 |
0.796 | 0.087 | -3 | 0.798 |
WNK1 |
0.795 | 0.018 | -2 | 0.910 |
PKCD |
0.795 | 0.011 | 2 | 0.174 |
PAK1 |
0.795 | 0.036 | -2 | 0.828 |
MSK2 |
0.795 | 0.087 | -3 | 0.807 |
NIK |
0.795 | 0.022 | -3 | 0.887 |
TSSK2 |
0.795 | 0.043 | -5 | 0.840 |
CLK4 |
0.795 | 0.148 | -3 | 0.829 |
PKACB |
0.794 | 0.105 | -2 | 0.722 |
PRKX |
0.794 | 0.122 | -3 | 0.756 |
PDHK4 |
0.794 | -0.125 | 1 | 0.821 |
ULK2 |
0.793 | -0.150 | 2 | 0.166 |
LATS1 |
0.793 | 0.106 | -3 | 0.868 |
MYLK4 |
0.792 | 0.135 | -2 | 0.816 |
AMPKA2 |
0.792 | 0.031 | -3 | 0.866 |
TSSK1 |
0.792 | 0.028 | -3 | 0.900 |
BMPR2 |
0.792 | -0.077 | -2 | 0.894 |
BMPR1B |
0.791 | 0.150 | 1 | 0.828 |
NIM1 |
0.791 | -0.032 | 3 | 0.786 |
MAPKAPK3 |
0.791 | 0.040 | -3 | 0.833 |
KIS |
0.791 | 0.029 | 1 | 0.701 |
MASTL |
0.791 | -0.052 | -2 | 0.836 |
BRSK1 |
0.791 | 0.036 | -3 | 0.835 |
PASK |
0.790 | 0.259 | -3 | 0.882 |
TBK1 |
0.790 | -0.096 | 1 | 0.686 |
CAMK4 |
0.790 | 0.027 | -3 | 0.854 |
CLK1 |
0.790 | 0.132 | -3 | 0.811 |
DRAK1 |
0.790 | 0.213 | 1 | 0.779 |
SRPK2 |
0.790 | 0.080 | -3 | 0.754 |
GRK6 |
0.789 | 0.045 | 1 | 0.817 |
QSK |
0.789 | 0.052 | 4 | 0.821 |
PKCB |
0.788 | -0.004 | 2 | 0.162 |
PKCG |
0.788 | -0.001 | 2 | 0.177 |
IKKA |
0.788 | -0.013 | -2 | 0.747 |
JNK2 |
0.788 | 0.114 | 1 | 0.633 |
GRK5 |
0.787 | -0.070 | -3 | 0.826 |
PAK3 |
0.787 | -0.011 | -2 | 0.825 |
MNK1 |
0.787 | 0.034 | -2 | 0.837 |
MARK3 |
0.787 | 0.086 | 4 | 0.778 |
NEK6 |
0.786 | -0.104 | -2 | 0.858 |
CAMK1G |
0.786 | 0.095 | -3 | 0.821 |
DLK |
0.786 | 0.046 | 1 | 0.802 |
IKKE |
0.786 | -0.080 | 1 | 0.682 |
MLK1 |
0.786 | -0.096 | 2 | 0.206 |
AKT2 |
0.786 | 0.105 | -3 | 0.770 |
ULK1 |
0.786 | -0.143 | -3 | 0.810 |
PKCA |
0.785 | -0.016 | 2 | 0.149 |
TGFBR2 |
0.785 | -0.076 | -2 | 0.797 |
MNK2 |
0.785 | 0.010 | -2 | 0.825 |
PRKD3 |
0.785 | 0.047 | -3 | 0.806 |
PIM2 |
0.785 | 0.093 | -3 | 0.816 |
RIPK1 |
0.785 | -0.022 | 1 | 0.772 |
CDK18 |
0.785 | 0.048 | 1 | 0.635 |
CDK7 |
0.784 | 0.012 | 1 | 0.700 |
MELK |
0.784 | -0.004 | -3 | 0.853 |
BCKDK |
0.784 | -0.092 | -1 | 0.822 |
CHAK2 |
0.784 | -0.074 | -1 | 0.843 |
NEK7 |
0.784 | -0.129 | -3 | 0.834 |
SIK |
0.784 | 0.038 | -3 | 0.809 |
PDHK1 |
0.784 | -0.197 | 1 | 0.796 |
TGFBR1 |
0.784 | 0.056 | -2 | 0.811 |
AURB |
0.784 | 0.039 | -2 | 0.697 |
ATM |
0.783 | 0.032 | 1 | 0.761 |
BRSK2 |
0.783 | -0.010 | -3 | 0.852 |
WNK3 |
0.782 | -0.149 | 1 | 0.778 |
HIPK1 |
0.782 | 0.068 | 1 | 0.725 |
SGK3 |
0.782 | 0.057 | -3 | 0.825 |
MLK2 |
0.782 | -0.100 | 2 | 0.185 |
JNK3 |
0.782 | 0.089 | 1 | 0.666 |
PAK2 |
0.782 | -0.005 | -2 | 0.810 |
MLK3 |
0.782 | -0.072 | 2 | 0.170 |
QIK |
0.782 | -0.010 | -3 | 0.862 |
DCAMKL1 |
0.782 | 0.054 | -3 | 0.833 |
HIPK2 |
0.782 | 0.065 | 1 | 0.631 |
NUAK1 |
0.782 | 0.001 | -3 | 0.839 |
GRK4 |
0.781 | -0.052 | -2 | 0.854 |
AURA |
0.781 | 0.055 | -2 | 0.665 |
SRPK3 |
0.781 | 0.062 | -3 | 0.787 |
DNAPK |
0.781 | 0.070 | 1 | 0.682 |
CDK8 |
0.781 | -0.010 | 1 | 0.684 |
CDK1 |
0.780 | 0.061 | 1 | 0.656 |
PLK4 |
0.780 | -0.069 | 2 | 0.164 |
PAK6 |
0.780 | 0.004 | -2 | 0.738 |
GRK7 |
0.779 | 0.047 | 1 | 0.759 |
ANKRD3 |
0.779 | -0.087 | 1 | 0.824 |
PKG2 |
0.779 | 0.031 | -2 | 0.727 |
ALK4 |
0.779 | 0.005 | -2 | 0.840 |
MARK1 |
0.779 | 0.049 | 4 | 0.798 |
MARK2 |
0.778 | 0.024 | 4 | 0.743 |
PKCH |
0.778 | -0.040 | 2 | 0.150 |
DCAMKL2 |
0.778 | 0.028 | -3 | 0.851 |
SNRK |
0.778 | -0.077 | 2 | 0.161 |
IRE1 |
0.778 | -0.113 | 1 | 0.766 |
PLK1 |
0.778 | -0.019 | -2 | 0.805 |
CDK14 |
0.778 | 0.059 | 1 | 0.670 |
PKCZ |
0.778 | -0.041 | 2 | 0.162 |
DYRK3 |
0.777 | 0.110 | 1 | 0.722 |
CDK19 |
0.777 | -0.000 | 1 | 0.648 |
DYRK1A |
0.777 | 0.060 | 1 | 0.736 |
MEK1 |
0.777 | -0.022 | 2 | 0.251 |
PHKG1 |
0.777 | -0.062 | -3 | 0.860 |
CHK1 |
0.777 | 0.018 | -3 | 0.848 |
TTBK2 |
0.777 | -0.155 | 2 | 0.152 |
CDK17 |
0.776 | 0.032 | 1 | 0.579 |
IRE2 |
0.776 | -0.106 | 2 | 0.137 |
PKACA |
0.776 | 0.076 | -2 | 0.671 |
SSTK |
0.776 | -0.001 | 4 | 0.805 |
ALK2 |
0.776 | 0.065 | -2 | 0.821 |
CDK5 |
0.776 | 0.006 | 1 | 0.721 |
NEK9 |
0.776 | -0.170 | 2 | 0.178 |
DYRK1B |
0.775 | 0.073 | 1 | 0.669 |
CDK10 |
0.775 | 0.064 | 1 | 0.659 |
PLK3 |
0.775 | 0.011 | 2 | 0.286 |
P38A |
0.775 | 0.047 | 1 | 0.727 |
SMMLCK |
0.774 | 0.100 | -3 | 0.862 |
ACVR2B |
0.774 | 0.056 | -2 | 0.799 |
PKR |
0.774 | -0.067 | 1 | 0.810 |
P38B |
0.774 | 0.062 | 1 | 0.654 |
MLK4 |
0.773 | -0.100 | 2 | 0.161 |
YSK4 |
0.773 | -0.034 | 1 | 0.746 |
CAMK1D |
0.773 | 0.075 | -3 | 0.756 |
BMPR1A |
0.773 | 0.102 | 1 | 0.806 |
GAK |
0.773 | 0.231 | 1 | 0.890 |
P38G |
0.772 | 0.041 | 1 | 0.573 |
ERK7 |
0.771 | -0.038 | 2 | 0.110 |
DAPK3 |
0.771 | 0.099 | -3 | 0.847 |
CDK13 |
0.771 | -0.009 | 1 | 0.666 |
CDK16 |
0.770 | 0.040 | 1 | 0.597 |
MST3 |
0.770 | 0.029 | 2 | 0.241 |
HIPK3 |
0.770 | 0.029 | 1 | 0.711 |
VRK2 |
0.769 | -0.165 | 1 | 0.840 |
ACVR2A |
0.769 | 0.005 | -2 | 0.783 |
P70S6K |
0.769 | 0.034 | -3 | 0.780 |
MPSK1 |
0.769 | 0.031 | 1 | 0.826 |
CDK3 |
0.769 | 0.047 | 1 | 0.603 |
MEKK3 |
0.769 | 0.016 | 1 | 0.773 |
CDK2 |
0.769 | 0.007 | 1 | 0.728 |
NEK2 |
0.769 | -0.126 | 2 | 0.166 |
PRP4 |
0.769 | 0.032 | -3 | 0.777 |
DAPK1 |
0.768 | 0.114 | -3 | 0.837 |
ERK1 |
0.768 | 0.012 | 1 | 0.646 |
GRK2 |
0.768 | 0.000 | -2 | 0.738 |
AKT1 |
0.768 | 0.053 | -3 | 0.786 |
CK1E |
0.767 | -0.001 | -3 | 0.537 |
PKCT |
0.767 | -0.037 | 2 | 0.139 |
CDK9 |
0.766 | -0.011 | 1 | 0.670 |
SMG1 |
0.766 | -0.034 | 1 | 0.774 |
BRAF |
0.766 | -0.053 | -4 | 0.855 |
ERK2 |
0.765 | -0.007 | 1 | 0.676 |
MAK |
0.765 | 0.100 | -2 | 0.779 |
CDK12 |
0.765 | -0.006 | 1 | 0.635 |
CK2A2 |
0.765 | 0.077 | 1 | 0.786 |
PKCE |
0.764 | 0.009 | 2 | 0.165 |
TLK2 |
0.764 | -0.099 | 1 | 0.767 |
SGK1 |
0.764 | 0.088 | -3 | 0.703 |
P38D |
0.763 | 0.064 | 1 | 0.600 |
GSK3A |
0.763 | 0.049 | 4 | 0.508 |
WNK4 |
0.763 | -0.090 | -2 | 0.897 |
MAPKAPK5 |
0.763 | -0.029 | -3 | 0.786 |
MEK5 |
0.763 | -0.133 | 2 | 0.211 |
AKT3 |
0.762 | 0.073 | -3 | 0.720 |
CHAK1 |
0.762 | -0.169 | 2 | 0.149 |
PAK4 |
0.762 | -0.007 | -2 | 0.677 |
GSK3B |
0.762 | 0.032 | 4 | 0.501 |
IRAK4 |
0.762 | -0.116 | 1 | 0.760 |
PKCI |
0.761 | -0.042 | 2 | 0.152 |
NEK5 |
0.761 | -0.084 | 1 | 0.803 |
ZAK |
0.761 | -0.122 | 1 | 0.739 |
JNK1 |
0.760 | 0.072 | 1 | 0.627 |
LKB1 |
0.760 | 0.002 | -3 | 0.835 |
PAK5 |
0.760 | -0.015 | -2 | 0.673 |
PHKG2 |
0.759 | -0.060 | -3 | 0.838 |
CK2A1 |
0.759 | 0.089 | 1 | 0.767 |
MEKK2 |
0.759 | -0.129 | 2 | 0.178 |
MRCKA |
0.758 | 0.077 | -3 | 0.810 |
SBK |
0.758 | 0.096 | -3 | 0.669 |
TAO3 |
0.758 | -0.053 | 1 | 0.770 |
ROCK2 |
0.758 | 0.066 | -3 | 0.841 |
MEKK1 |
0.758 | -0.168 | 1 | 0.769 |
NEK11 |
0.757 | -0.026 | 1 | 0.750 |
MRCKB |
0.757 | 0.066 | -3 | 0.802 |
CAMK1A |
0.757 | 0.056 | -3 | 0.731 |
CHK2 |
0.757 | 0.072 | -3 | 0.722 |
GCK |
0.756 | 0.061 | 1 | 0.772 |
PKN1 |
0.756 | 0.003 | -3 | 0.797 |
MOK |
0.756 | 0.066 | 1 | 0.751 |
PINK1 |
0.756 | -0.107 | 1 | 0.832 |
PERK |
0.755 | -0.184 | -2 | 0.835 |
CK1D |
0.755 | 0.000 | -3 | 0.489 |
DMPK1 |
0.755 | 0.119 | -3 | 0.818 |
YANK3 |
0.755 | -0.029 | 2 | 0.157 |
TLK1 |
0.753 | -0.101 | -2 | 0.838 |
GRK3 |
0.753 | -0.010 | -2 | 0.698 |
TTBK1 |
0.753 | -0.149 | 2 | 0.142 |
PBK |
0.752 | 0.066 | 1 | 0.840 |
PLK2 |
0.752 | 0.004 | -3 | 0.711 |
CK1A2 |
0.752 | -0.012 | -3 | 0.492 |
MEKK6 |
0.752 | -0.071 | 1 | 0.771 |
IRAK1 |
0.752 | -0.152 | -1 | 0.761 |
STK33 |
0.752 | -0.078 | 2 | 0.175 |
HRI |
0.752 | -0.188 | -2 | 0.851 |
NEK8 |
0.752 | -0.124 | 2 | 0.190 |
PDK1 |
0.751 | -0.048 | 1 | 0.751 |
TAK1 |
0.751 | 0.041 | 1 | 0.797 |
HPK1 |
0.751 | 0.036 | 1 | 0.747 |
CAMKK1 |
0.750 | -0.082 | -2 | 0.759 |
CDK6 |
0.748 | -0.006 | 1 | 0.653 |
TAO2 |
0.748 | -0.114 | 2 | 0.196 |
CRIK |
0.748 | 0.081 | -3 | 0.790 |
MST2 |
0.748 | -0.038 | 1 | 0.774 |
BUB1 |
0.748 | 0.008 | -5 | 0.804 |
MAP3K15 |
0.747 | -0.096 | 1 | 0.729 |
CK1G1 |
0.747 | -0.066 | -3 | 0.511 |
CAMKK2 |
0.747 | -0.084 | -2 | 0.752 |
CDK4 |
0.746 | -0.009 | 1 | 0.624 |
PDHK3_TYR |
0.745 | 0.181 | 4 | 0.901 |
NEK4 |
0.744 | -0.128 | 1 | 0.747 |
EEF2K |
0.743 | -0.086 | 3 | 0.787 |
LRRK2 |
0.743 | -0.105 | 2 | 0.207 |
TNIK |
0.743 | -0.069 | 3 | 0.826 |
ROCK1 |
0.742 | 0.051 | -3 | 0.812 |
PDHK4_TYR |
0.742 | 0.243 | 2 | 0.297 |
KHS2 |
0.742 | -0.014 | 1 | 0.749 |
MINK |
0.741 | -0.094 | 1 | 0.750 |
NEK1 |
0.741 | -0.102 | 1 | 0.762 |
KHS1 |
0.740 | -0.046 | 1 | 0.731 |
LOK |
0.740 | -0.090 | -2 | 0.792 |
VRK1 |
0.740 | -0.106 | 2 | 0.224 |
HGK |
0.739 | -0.119 | 3 | 0.823 |
PKG1 |
0.739 | 0.002 | -2 | 0.645 |
MST1 |
0.739 | -0.057 | 1 | 0.751 |
SLK |
0.739 | -0.047 | -2 | 0.731 |
MAP2K6_TYR |
0.738 | 0.232 | -1 | 0.876 |
RIPK2 |
0.736 | -0.135 | 1 | 0.698 |
TESK1_TYR |
0.735 | 0.023 | 3 | 0.865 |
YSK1 |
0.735 | -0.125 | 2 | 0.162 |
MEK2 |
0.733 | -0.182 | 2 | 0.189 |
BIKE |
0.733 | 0.066 | 1 | 0.805 |
BMPR2_TYR |
0.733 | 0.159 | -1 | 0.881 |
MAP2K4_TYR |
0.733 | 0.087 | -1 | 0.860 |
EPHA6 |
0.732 | 0.121 | -1 | 0.844 |
PDHK1_TYR |
0.731 | 0.127 | -1 | 0.878 |
HASPIN |
0.730 | -0.018 | -1 | 0.734 |
EPHB4 |
0.729 | 0.112 | -1 | 0.820 |
PKMYT1_TYR |
0.729 | -0.040 | 3 | 0.842 |
MAP2K7_TYR |
0.729 | -0.021 | 2 | 0.247 |
EPHA4 |
0.728 | 0.134 | 2 | 0.329 |
TTK |
0.728 | -0.080 | -2 | 0.822 |
LIMK2_TYR |
0.728 | -0.030 | -3 | 0.891 |
OSR1 |
0.727 | -0.095 | 2 | 0.186 |
TXK |
0.726 | 0.163 | 1 | 0.861 |
ASK1 |
0.724 | -0.119 | 1 | 0.715 |
PINK1_TYR |
0.723 | -0.092 | 1 | 0.822 |
NEK3 |
0.722 | -0.184 | 1 | 0.719 |
CK1A |
0.722 | -0.030 | -3 | 0.394 |
ALPHAK3 |
0.721 | -0.017 | -1 | 0.753 |
MYO3B |
0.720 | -0.111 | 2 | 0.169 |
AAK1 |
0.720 | 0.088 | 1 | 0.723 |
ITK |
0.719 | 0.148 | -1 | 0.768 |
DDR1 |
0.719 | 0.012 | 4 | 0.801 |
TNK2 |
0.719 | 0.026 | 3 | 0.752 |
EPHB3 |
0.719 | 0.081 | -1 | 0.803 |
SRMS |
0.718 | 0.129 | 1 | 0.837 |
RET |
0.718 | -0.057 | 1 | 0.761 |
EPHB2 |
0.718 | 0.091 | -1 | 0.797 |
PTK2 |
0.717 | 0.161 | -1 | 0.810 |
EPHB1 |
0.717 | 0.082 | 1 | 0.823 |
LIMK1_TYR |
0.716 | -0.163 | 2 | 0.193 |
TYRO3 |
0.716 | -0.081 | 3 | 0.784 |
INSRR |
0.716 | -0.005 | 3 | 0.745 |
YES1 |
0.716 | 0.030 | -1 | 0.798 |
JAK3 |
0.716 | 0.006 | 1 | 0.755 |
BLK |
0.716 | 0.117 | -1 | 0.802 |
MYO3A |
0.714 | -0.131 | 1 | 0.725 |
YANK2 |
0.714 | -0.056 | 2 | 0.154 |
MST1R |
0.714 | -0.070 | 3 | 0.806 |
FGFR2 |
0.714 | -0.005 | 3 | 0.799 |
FGR |
0.714 | 0.000 | 1 | 0.857 |
TAO1 |
0.713 | -0.145 | 1 | 0.682 |
EPHA3 |
0.713 | 0.040 | 2 | 0.286 |
EPHA7 |
0.713 | 0.065 | 2 | 0.292 |
CSF1R |
0.712 | -0.033 | 3 | 0.792 |
EPHA5 |
0.712 | 0.104 | 2 | 0.322 |
ABL2 |
0.712 | -0.023 | -1 | 0.748 |
LCK |
0.711 | 0.061 | -1 | 0.796 |
FYN |
0.710 | 0.127 | -1 | 0.784 |
ROS1 |
0.710 | -0.167 | 3 | 0.759 |
MERTK |
0.710 | -0.017 | 3 | 0.782 |
BMX |
0.709 | 0.095 | -1 | 0.674 |
KDR |
0.709 | -0.019 | 3 | 0.770 |
HCK |
0.709 | 0.001 | -1 | 0.789 |
AXL |
0.709 | -0.054 | 3 | 0.785 |
DDR2 |
0.709 | 0.075 | 3 | 0.731 |
TEK |
0.708 | -0.003 | 3 | 0.725 |
FER |
0.708 | -0.060 | 1 | 0.859 |
PTK2B |
0.708 | 0.056 | -1 | 0.708 |
ABL1 |
0.707 | -0.048 | -1 | 0.734 |
KIT |
0.707 | 0.014 | 3 | 0.792 |
TNK1 |
0.706 | -0.107 | 3 | 0.770 |
FGFR3 |
0.706 | 0.022 | 3 | 0.777 |
FLT1 |
0.706 | 0.057 | -1 | 0.824 |
STLK3 |
0.706 | -0.168 | 1 | 0.706 |
TYK2 |
0.706 | -0.247 | 1 | 0.755 |
JAK2 |
0.705 | -0.198 | 1 | 0.749 |
MET |
0.705 | -0.002 | 3 | 0.783 |
FGFR1 |
0.704 | -0.092 | 3 | 0.765 |
NEK10_TYR |
0.703 | -0.108 | 1 | 0.659 |
PDGFRB |
0.703 | -0.176 | 3 | 0.795 |
EPHA8 |
0.702 | 0.046 | -1 | 0.800 |
EPHA1 |
0.701 | -0.039 | 3 | 0.761 |
TEC |
0.701 | 0.003 | -1 | 0.669 |
TNNI3K_TYR |
0.699 | -0.139 | 1 | 0.758 |
EPHA2 |
0.699 | 0.080 | -1 | 0.761 |
FLT4 |
0.698 | -0.049 | 3 | 0.761 |
FLT3 |
0.698 | -0.118 | 3 | 0.777 |
NTRK1 |
0.697 | -0.109 | -1 | 0.786 |
LYN |
0.696 | 0.020 | 3 | 0.712 |
ERBB2 |
0.696 | -0.063 | 1 | 0.726 |
WEE1_TYR |
0.695 | -0.095 | -1 | 0.729 |
BTK |
0.695 | -0.076 | -1 | 0.714 |
SRC |
0.695 | 0.035 | -1 | 0.764 |
FRK |
0.694 | -0.022 | -1 | 0.786 |
LTK |
0.694 | -0.139 | 3 | 0.733 |
SYK |
0.694 | 0.091 | -1 | 0.778 |
JAK1 |
0.693 | -0.162 | 1 | 0.694 |
INSR |
0.693 | -0.117 | 3 | 0.721 |
PDGFRA |
0.692 | -0.227 | 3 | 0.789 |
ALK |
0.690 | -0.179 | 3 | 0.701 |
CSK |
0.689 | -0.052 | 2 | 0.276 |
FGFR4 |
0.689 | -0.025 | -1 | 0.733 |
EGFR |
0.689 | -0.042 | 1 | 0.633 |
PTK6 |
0.688 | -0.205 | -1 | 0.682 |
NTRK2 |
0.688 | -0.171 | 3 | 0.762 |
MATK |
0.688 | -0.055 | -1 | 0.689 |
ERBB4 |
0.688 | 0.032 | 1 | 0.658 |
CK1G3 |
0.688 | -0.061 | -3 | 0.346 |
NTRK3 |
0.688 | -0.109 | -1 | 0.738 |
IGF1R |
0.681 | -0.096 | 3 | 0.664 |
CK1G2 |
0.678 | -0.021 | -3 | 0.433 |
ZAP70 |
0.675 | 0.039 | -1 | 0.704 |
MUSK |
0.671 | -0.148 | 1 | 0.638 |
FES |
0.666 | -0.069 | -1 | 0.648 |