Motif 125 (n=257)

Position-wise Probabilities

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uniprot genes site source protein function
A7KAX9 ARHGAP32 S1794 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
H7C1W4 None S343 ochoa Uncharacterized protein None
O14994 SYN3 S539 ochoa Synapsin-3 (Synapsin III) May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15014 ZNF609 S1285 ochoa Zinc finger protein 609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.
O15169 AXIN1 S215 ochoa Axin-1 (Axis inhibition protein 1) (hAxin) Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}.
O43182 ARHGAP6 S635 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43426 SYNJ1 S1223 ochoa Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}.
O43493 TGOLN2 S349 ochoa Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) May be involved in regulating membrane traffic to and from trans-Golgi network.
O43524 FOXO3 S553 ochoa Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O60292 SIPA1L3 S1307 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60303 KATNIP S691 ochoa Katanin-interacting protein May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}.
O60447 EVI5 S113 ochoa Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}.
O60888 CUTA S46 ochoa Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).
O60907 TBL1X S474 psp F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}.
O75420 GIGYF1 S860 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75420 GIGYF1 S863 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75717 WDHD1 S886 ochoa WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
O75940 SMNDC1 S61 ochoa Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}.
O75970 MPDZ S1818 ochoa Multiple PDZ domain protein (Multi-PDZ domain protein 1) Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.
O76039 CDKL5 S477 ochoa Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}.
O94804 STK10 S369 ochoa Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
O94885 SASH1 S329 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94916 NFAT5 S646 ochoa Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
O95235 KIF20A S254 ochoa Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95243 MBD4 S319 ochoa Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.
O95475 SIX6 S225 ochoa Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) May be involved in eye development.
O96017 CHEK2 S33 psp Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}.
P01100 FOS S362 ochoa|psp Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
P04049 RAF1 S497 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P07332 FES S70 ochoa Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}.
P08172 CHRM2 S309 psp Muscarinic acetylcholine receptor M2 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.
P08195 SLC3A2 S406 psp Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}.
P08240 SRPRA S296 ochoa Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}.
P0DJ93 SMIM13 S58 ochoa Small integral membrane protein 13 None
P13010 XRCC5 S577 ochoa|psp X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.
P15056 BRAF S605 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P15924 DSP S2551 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P19447 ERCC3 S231 ochoa General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}.
P20719 HOXA5 S121 ochoa Homeobox protein Hox-A5 (Homeobox protein Hox-1C) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
P21802 FGFR2 S780 psp Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.
P30260 CDC27 S220 ochoa Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P30559 OXTR S366 ochoa Oxytocin receptor (OT-R) Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
P30559 OXTR S368 ochoa Oxytocin receptor (OT-R) Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
P31943 HNRNPH1 S21 ochoa Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P38432 COIL S235 ochoa Coilin (p80-coilin) Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.
P42574 CASP3 S24 ochoa Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}.
P42695 NCAPD3 S1382 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P45880 VDAC2 S46 ochoa Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P46108 CRK S41 ochoa|psp Adapter molecule crk (Proto-oncogene c-Crk) (p38) Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}.
P46531 NOTCH1 S2522 psp Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.
P48553 TRAPPC10 S1201 ochoa Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. {ECO:0000269|PubMed:11805826, ECO:0000269|PubMed:31467083, ECO:0000269|PubMed:35298461}.
P51531 SMARCA2 S698 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51531 SMARCA2 S1408 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51587 BRCA2 S1968 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P54132 BLM S1379 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
P54920 NAPA S24 ochoa Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.
P55040 GEM S57 ochoa GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
P55197 MLLT10 S404 ochoa Protein AF-10 (ALL1-fused gene from chromosome 10 protein) Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.
P57078 RIPK4 S404 ochoa Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}.
P98082 DAB2 S262 ochoa Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
P98171 ARHGAP4 S408 ochoa Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q01081 U2AF1 S59 ochoa Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}.
Q02241 KIF23 S716 ochoa|psp Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}.
Q03164 KMT2A S2283 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04724 TLE1 S284 ochoa Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}.
Q07157 TJP1 S1577 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q09019 DMWD Y543 ochoa Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}.
Q12800 TFCP2 S289 psp Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}.
Q12948 FOXC1 S527 ochoa Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.
Q12955 ANK3 S911 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q12959 DLG1 S568 ochoa Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.
Q13422 IKZF1 S391 ochoa|psp DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.
Q13546 RIPK1 S331 ochoa Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}.
Q13627 DYRK1A S502 ochoa Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}.
Q13796 SHROOM2 S193 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14123 PDE1C S486 ochoa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}.
Q14157 UBAP2L S317 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14202 ZMYM3 S1047 ochoa Zinc finger MYM-type protein 3 (Zinc finger protein 261) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q14315 FLNC Y2625 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14573 ITPR3 S1832 ochoa|psp Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}.
Q14669 TRIP12 S161 ochoa E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}.
Q15022 SUZ12 S382 ochoa Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q15052 ARHGEF6 S561 ochoa Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Q15345 LRRC41 S357 ochoa Leucine-rich repeat-containing protein 41 (Protein Muf1) Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.
Q15648 MED1 S1227 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15648 MED1 S1252 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15648 MED1 S1532 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15648 MED1 S1534 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q16473 TNXA S139 ochoa Putative tenascin-XA (TN-XA) None
Q16659 MAPK6 S556 ochoa Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
Q16799 RTN1 S164 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q17R98 ZNF827 S961 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q2LD37 BLTP1 S1226 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q49A88 CCDC14 S124 ochoa Coiled-coil domain-containing protein 14 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.
Q4AC94 C2CD3 S299 ochoa C2 domain-containing protein 3 Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.
Q5H9M0 PWWP3B S107 ochoa PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1) None
Q5QP82 DCAF10 S349 ochoa DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.
Q5SR56 MFSD14B S466 ochoa Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B) None
Q5SW79 CEP170 S578 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T481 RBM20 S740 ochoa RNA-binding protein 20 (RNA-binding motif protein 20) RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.
Q5THJ4 VPS13D S2436 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5TZA2 CROCC S462 ochoa Rootletin (Ciliary rootlet coiled-coil protein) Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.
Q5VT25 CDC42BPA S1609 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q5VVJ2 MYSM1 S265 ochoa Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}.
Q5XUX1 FBXW9 S61 ochoa F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
Q63ZY3 KANK2 S425 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q684P5 RAP1GAP2 S698 ochoa Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.
Q68CZ2 TNS3 S388 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68DA7 FMN1 S396 ochoa Formin-1 (Limb deformity protein homolog) Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.
Q6DCA0 AMMECR1L S27 ochoa AMMECR1-like protein None
Q6P444 MTFR2 S171 ochoa Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}.
Q6P4F7 ARHGAP11A S886 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6PJP8 DCLRE1A S238 ochoa DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}.
Q6T4R5 NHS S991 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6T4R5 NHS S1410 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6T4R5 NHS S1477 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6UXY1 BAIAP2L2 S299 ochoa BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.
Q6UXY8 TMC5 S84 ochoa Transmembrane channel-like protein 5 Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}.
Q70CQ4 USP31 S803 ochoa Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}.
Q71F56 MED13L S1641 ochoa Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Q76N89 HECW1 S66 ochoa E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Q7L804 RAB11FIP2 S227 ochoa|psp Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}.
Q7LBC6 KDM3B S1320 ochoa Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.
Q7Z3C6 ATG9A S675 ochoa Autophagy-related protein 9A (APG9-like 1) (mATG9) Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}.
Q7Z401 DENND4A S963 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z402 TMC7 S87 ochoa Transmembrane channel-like protein 7 Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}.
Q7Z460 CLASP1 S254 ochoa CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
Q7Z4S6 KIF21A S1307 ochoa Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}.
Q7Z4V5 HDGFL2 S142 ochoa Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}.
Q86SJ2 AMIGO2 S443 ochoa Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Q86SQ0 PHLDB2 S173 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86TC9 MYPN S198 ochoa Myopalladin (145 kDa sarcomeric protein) Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.
Q86TI0 TBC1D1 S525 ochoa TBC1 domain family member 1 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86U06 RBM23 S41 ochoa Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}.
Q86VP3 PACS2 S700 ochoa Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}.
Q86X51 EZHIP S336 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q86XA9 HEATR5A S827 ochoa HEAT repeat-containing protein 5A None
Q86XP3 DDX42 S715 ochoa ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}.
Q86XR8 CEP57 S53 ochoa Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}.
Q86XZ4 SPATS2 S208 ochoa Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) None
Q8IU60 DCP2 S247 ochoa m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:28002401}.
Q8IVL0 NAV3 S1670 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IVL1 NAV2 S1363 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVL1 NAV2 S1611 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVL1 NAV2 S1854 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVT5 KSR1 S194 ochoa Kinase suppressor of Ras 1 (EC 2.7.11.1) Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.
Q8IWB9 TEX2 S141 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IWQ3 BRSK2 S410 ochoa Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.
Q8IWS0 PHF6 S55 ochoa PHD finger protein 6 (PHD-like zinc finger protein) Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}.
Q8IWU2 LMTK2 S1395 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8N5A5 ZGPAT S276 ochoa Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}.
Q8N9B5 JMY S854 ochoa Junction-mediating and -regulatory protein Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}.
Q8NCN4 RNF169 S292 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8NEG4 FAM83F S480 ochoa Protein FAM83F None
Q8NEV8 EXPH5 S318 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEY1 NAV1 S1182 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8TBA6 GOLGA5 S187 ochoa Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
Q8TBE0 BAHD1 S543 ochoa Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}.
Q8TDM6 DLG5 S886 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TDN4 CABLES1 S418 ochoa CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Q8TF40 FNIP1 S97 ochoa Folliculin-interacting protein 1 Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}.
Q8TF71 SLC16A10 S266 ochoa Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}.
Q8WX93 PALLD S1333 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WXG6 MADD S1239 ochoa MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}.
Q8WXI2 CNKSR2 S685 ochoa Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}.
Q8WXI7 MUC16 S6336 ochoa Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Q8WYB5 KAT6B S522 ochoa Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.
Q92610 ZNF592 S346 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q93075 TATDN2 S400 ochoa 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}.
Q96CP6 GRAMD1A S584 ochoa Protein Aster-A (GRAM domain-containing protein 1A) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.
Q96D09 GPRASP2 S282 ochoa G-protein coupled receptor-associated sorting protein 2 (GASP-2) May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}.
Q96DY7 MTBP S756 ochoa Mdm2-binding protein (hMTBP) Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.
Q96EB6 SIRT1 S659 psp NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.
Q96EN8 MOCOS S528 ochoa Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608). {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608, ECO:0000269|PubMed:34356852}.
Q96EV2 RBM33 S739 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q96HC4 PDLIM5 S134 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96IZ7 RSRC1 S237 ochoa Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}.
Q96JA1 LRIG1 S1033 ochoa Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.
Q96MK2 RIPOR3 S22 ochoa RIPOR family member 3 None
Q96MK2 RIPOR3 S397 ochoa RIPOR family member 3 None
Q96Q15 SMG1 S34 ochoa Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.
Q96QT4 TRPM7 S101 ochoa Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96SK2 TMEM209 S176 ochoa Transmembrane protein 209 Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}.
Q96SN8 CDK5RAP2 S841 ochoa CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}.
Q96ST8 CEP89 S77 ochoa Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}.
Q96T58 SPEN S749 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99570 PIK3R4 S892 ochoa Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}.
Q99728 BARD1 S389 ochoa BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}.
Q99767 APBA2 S236 psp Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Q99959 PKP2 S225 ochoa Plakophilin-2 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}.
Q99963 SH3GL3 S263 ochoa Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Q9BSC4 NOL10 S632 ochoa Nucleolar protein 10 None
Q9BVL2 NUP58 S540 ochoa Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}.
Q9BX66 SORBS1 S280 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXW9 FANCD2 S592 ochoa|psp Fanconi anemia group D2 protein (Protein FACD2) Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}.
Q9BYI3 HYCC1 S431 ochoa Hyccin (Down-regulated by CTNNB1 protein A) Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}.
Q9BYP7 WNK3 S1471 ochoa Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}.
Q9BZB8 CPEB1 S178 ochoa Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}.
Q9BZL4 PPP1R12C S336 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9C0A6 SETD5 S539 ochoa Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.
Q9C0D5 TANC1 S182 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H2Y7 ZNF106 S1468 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H4H8 FAM83D S472 ochoa Protein FAM83D (Spindle protein CHICA) Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}.
Q9H582 ZNF644 S637 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H6S0 YTHDC2 S1184 ochoa 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}.
Q9H992 MARCHF7 S359 ochoa E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}.
Q9H992 MARCHF7 S366 ochoa E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}.
Q9HCS7 XAB2 S749 ochoa Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q9NQG6 MIEF1 S92 ochoa Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}.
Q9NRR5 UBQLN4 S133 ochoa Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9NSI8 SAMSN1 S123 ochoa SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}.
Q9NV56 MRGBP S147 ochoa MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Q9NXV6 CDKN2AIP S209 ochoa CDKN2A-interacting protein (Collaborator of ARF) Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}.
Q9NXX6 NSMCE4A S61 ochoa Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}.
Q9NYB9 ABI2 S242 ochoa Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
Q9NZ09 UBAP1 S265 ochoa Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}.
Q9NZB2 FAM120A S923 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9P0U3 SENP1 S106 ochoa Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}.
Q9P0U3 SENP1 S159 ochoa Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}.
Q9P1T7 MDFIC S138 ochoa MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}.
Q9P2R6 RERE S613 ochoa Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.
Q9P2R6 RERE S679 ochoa Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.
Q9UBF6 RNF7 S20 ochoa RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581). {ECO:0000250|UniProtKB:Q9WTZ1, ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:38574733}.; FUNCTION: [Isoform 2]: Inactive. {ECO:0000269|PubMed:11506706}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:23300442}.
Q9UBL0 ARPP21 S395 ochoa cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.
Q9UBP0 SPAST S268 ochoa|psp Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}.
Q9UDT6 CLIP2 S314 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UDT6 CLIP2 S317 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UHB7 AFF4 S118 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UHB7 AFF4 S836 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UHI6 DDX20 S500 ochoa Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
Q9UHV7 MED13 S481 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UIJ5 ZDHHC2 S331 ochoa Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}.
Q9UKX7 NUP50 S268 ochoa Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
Q9ULD2 MTUS1 S199 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9ULE6 PALD1 S32 ochoa Paladin None
Q9ULJ7 ANKRD50 S1138 ochoa Ankyrin repeat domain-containing protein 50 Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Q9ULL8 SHROOM4 S785 ochoa Protein Shroom4 (Second homolog of apical protein) Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}.
Q9ULT0 TTC7A S672 ochoa Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}.
Q9UPR0 PLCL2 S123 ochoa Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.
Q9UPU9 SAMD4A S649 ochoa Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.
Q9UPZ3 HPS5 S461 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9Y250 LZTS1 S231 ochoa Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
Q9Y253 POLH S512 ochoa|psp DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}.
Q9Y294 ASF1A S181 ochoa Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}.
Q9Y2G3 ATP11B S1154 ochoa Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.
Q9Y2H9 MAST1 S159 ochoa Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.
Q9Y2I7 PIKFYVE S491 ochoa 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}.
Q9Y2L6 FRMD4B S776 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y485 DMXL1 S1256 ochoa DmX-like protein 1 (X-like 1 protein) None
Q9Y4K4 MAP4K5 S434 ochoa Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
Q9Y6Q6 TNFRSF11A S511 ochoa Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). {ECO:0000250|UniProtKB:O35305, ECO:0000269|PubMed:9878548}.
V9GY48 None S182 ochoa Zinc finger CCCH-type with G patch domain-containing protein None
Q12968 NFATC3 S161 Sugiyama Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}.
Q15751 HERC1 S3238 Sugiyama Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
Q14C86 GAPVD1 S740 Sugiyama GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}.
Q15118 PDK1 S27 Sugiyama [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}.
Q9Y5K5 UCHL5 S131 Sugiyama Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}.
Download
reactome_id name p -log10_p
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.000064 4.192
R-HSA-1839126 FGFR2 mutant receptor activation 0.000107 3.969
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.000932 3.031
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.000944 3.025
R-HSA-5655253 Signaling by FGFR2 in disease 0.000524 3.281
R-HSA-109704 PI3K Cascade 0.000524 3.281
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.000741 3.130
R-HSA-112399 IRS-mediated signalling 0.000942 3.026
R-HSA-190241 FGFR2 ligand binding and activation 0.001090 2.963
R-HSA-2428928 IRS-related events triggered by IGF1R 0.001274 2.895
R-HSA-2428924 IGF1R signaling cascade 0.001578 2.802
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.001690 2.772
R-HSA-74751 Insulin receptor signalling cascade 0.001578 2.802
R-HSA-5654695 PI-3K cascade:FGFR2 0.002062 2.686
R-HSA-5654699 SHC-mediated cascade:FGFR2 0.002579 2.589
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.002868 2.542
R-HSA-1226099 Signaling by FGFR in disease 0.002996 2.524
R-HSA-2023837 Signaling by FGFR2 amplification mutants 0.003385 2.470
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 0.003385 2.470
R-HSA-5654738 Signaling by FGFR2 0.004211 2.376
R-HSA-205025 NADE modulates death signalling 0.004820 2.317
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.005044 2.297
R-HSA-191859 snRNP Assembly 0.006066 2.217
R-HSA-194441 Metabolism of non-coding RNA 0.006066 2.217
R-HSA-5654696 Downstream signaling of activated FGFR2 0.006014 2.221
R-HSA-9768919 NPAS4 regulates expression of target genes 0.005533 2.257
R-HSA-447038 NrCAM interactions 0.006488 2.188
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.008235 2.084
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.009194 2.037
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.009194 2.037
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.009194 2.037
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.009194 2.037
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.007057 2.151
R-HSA-2033519 Activated point mutants of FGFR2 0.007338 2.134
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.008381 2.077
R-HSA-5693532 DNA Double-Strand Break Repair 0.009459 2.024
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.008381 2.077
R-HSA-74752 Signaling by Insulin receptor 0.008414 2.075
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.009572 2.019
R-HSA-9656223 Signaling by RAF1 mutants 0.010170 1.993
R-HSA-5674135 MAP2K and MAPK activation 0.010170 1.993
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.010490 1.979
R-HSA-5683057 MAPK family signaling cascades 0.010709 1.970
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.012808 1.893
R-HSA-9649948 Signaling downstream of RAS mutants 0.014058 1.852
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.014058 1.852
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.014058 1.852
R-HSA-6802949 Signaling by RAS mutants 0.014058 1.852
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.012808 1.893
R-HSA-73894 DNA Repair 0.013916 1.857
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.013662 1.864
R-HSA-190236 Signaling by FGFR 0.011378 1.944
R-HSA-162582 Signal Transduction 0.012917 1.889
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.012592 1.900
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.014108 1.851
R-HSA-9660537 Signaling by MRAS-complex mutants 0.015328 1.815
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.015328 1.815
R-HSA-5467345 Deletions in the AXIN1 gene destabilize the destruction complex 0.016811 1.774
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.016284 1.788
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.016370 1.786
R-HSA-170984 ARMS-mediated activation 0.018041 1.744
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.019827 1.703
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.020941 1.679
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.022316 1.651
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.023990 1.620
R-HSA-190377 FGFR2b ligand binding and activation 0.024021 1.619
R-HSA-451306 Ionotropic activity of kainate receptors 0.024021 1.619
R-HSA-4839735 Signaling by AXIN mutants 0.027273 1.564
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.025729 1.590
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.025729 1.590
R-HSA-1855170 IPs transport between nucleus and cytosol 0.029406 1.532
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.029406 1.532
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.027819 1.556
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.027535 1.560
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.029406 1.532
R-HSA-5693538 Homology Directed Repair 0.026189 1.582
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.027273 1.564
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.029406 1.532
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.026189 1.582
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.033340 1.477
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.033340 1.477
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.033340 1.477
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.033340 1.477
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.031344 1.504
R-HSA-72163 mRNA Splicing - Major Pathway 0.030298 1.519
R-HSA-5693537 Resolution of D-Loop Structures 0.031344 1.504
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.031344 1.504
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.030692 1.513
R-HSA-5673000 RAF activation 0.033346 1.477
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.033346 1.477
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.033346 1.477
R-HSA-180746 Nuclear import of Rev protein 0.033346 1.477
R-HSA-190375 FGFR2c ligand binding and activation 0.034271 1.465
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.035414 1.451
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.036755 1.435
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.035414 1.451
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.034271 1.465
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.034271 1.465
R-HSA-199991 Membrane Trafficking 0.037732 1.423
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.038003 1.420
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.044326 1.353
R-HSA-72172 mRNA Splicing 0.038851 1.411
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.042003 1.377
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.039742 1.401
R-HSA-5673001 RAF/MAP kinase cascade 0.039754 1.401
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.044326 1.353
R-HSA-446353 Cell-extracellular matrix interactions 0.041882 1.378
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.042003 1.377
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.044326 1.353
R-HSA-5684996 MAPK1/MAPK3 signaling 0.045011 1.347
R-HSA-8853333 Signaling by FGFR2 fusions 0.049593 1.305
R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 0.081286 1.090
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.096735 1.014
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.096735 1.014
R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 0.096735 1.014
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 0.096735 1.014
R-HSA-5083630 Defective LFNG causes SCDO3 0.096735 1.014
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.126861 0.897
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.126861 0.897
R-HSA-111957 Cam-PDE 1 activation 0.126861 0.897
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.126861 0.897
R-HSA-9732724 IFNG signaling activates MAPKs 0.155986 0.807
R-HSA-2562578 TRIF-mediated programmed cell death 0.155986 0.807
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.155986 0.807
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.155986 0.807
R-HSA-196025 Formation of annular gap junctions 0.170184 0.769
R-HSA-8875656 MET receptor recycling 0.170184 0.769
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 0.184143 0.735
R-HSA-190873 Gap junction degradation 0.184143 0.735
R-HSA-5218900 CASP8 activity is inhibited 0.184143 0.735
R-HSA-8875555 MET activates RAP1 and RAC1 0.197869 0.704
R-HSA-164843 2-LTR circle formation 0.197869 0.704
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.077539 1.110
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.077539 1.110
R-HSA-350054 Notch-HLH transcription pathway 0.082494 1.084
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.211364 0.675
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.211364 0.675
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.211364 0.675
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.211364 0.675
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.224633 0.649
R-HSA-5339716 Signaling by GSK3beta mutants 0.224633 0.649
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.046713 1.331
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.237680 0.624
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.237680 0.624
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.237680 0.624
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.237680 0.624
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.237680 0.624
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.237680 0.624
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.237680 0.624
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.108597 0.964
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.250508 0.601
R-HSA-69166 Removal of the Flap Intermediate 0.263121 0.580
R-HSA-196299 Beta-catenin phosphorylation cascade 0.275522 0.560
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.275522 0.560
R-HSA-176412 Phosphorylation of the APC/C 0.287716 0.541
R-HSA-5083625 Defective GALNT3 causes HFTC 0.287716 0.541
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.287716 0.541
R-HSA-5083636 Defective GALNT12 causes CRCS1 0.287716 0.541
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.050303 1.298
R-HSA-5696400 Dual Incision in GG-NER 0.153964 0.813
R-HSA-8964616 G beta:gamma signalling through CDC42 0.299705 0.523
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.096222 1.017
R-HSA-6782135 Dual incision in TC-NER 0.103053 0.987
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.311492 0.507
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 0.311492 0.507
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.068390 1.165
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.120930 0.917
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.120930 0.917
R-HSA-8854518 AURKA Activation by TPX2 0.132166 0.879
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.159690 0.797
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.233135 0.632
R-HSA-72165 mRNA Splicing - Minor Pathway 0.233135 0.632
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.167855 0.775
R-HSA-380287 Centrosome maturation 0.167855 0.775
R-HSA-112382 Formation of RNA Pol II elongation complex 0.270580 0.568
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.227915 0.642
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.320378 0.494
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.320378 0.494
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.320378 0.494
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.320378 0.494
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.320378 0.494
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.073890 1.131
R-HSA-1980143 Signaling by NOTCH1 0.171983 0.765
R-HSA-6802957 Oncogenic MAPK signaling 0.075073 1.125
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.215180 0.667
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.215180 0.667
R-HSA-69183 Processive synthesis on the lagging strand 0.275522 0.560
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.245597 0.610
R-HSA-5696398 Nucleotide Excision Repair 0.318852 0.496
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.215180 0.667
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.147684 0.831
R-HSA-191650 Regulation of gap junction activity 0.096735 1.014
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.114052 0.943
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.299705 0.523
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.276827 0.558
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.237680 0.624
R-HSA-4641265 Repression of WNT target genes 0.237680 0.624
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.276827 0.558
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.065019 1.187
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.184143 0.735
R-HSA-165158 Activation of AKT2 0.111925 0.951
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.170184 0.769
R-HSA-2025928 Calcineurin activates NFAT 0.184143 0.735
R-HSA-5656169 Termination of translesion DNA synthesis 0.119577 0.922
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.142289 0.847
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.311492 0.507
R-HSA-6783310 Fanconi Anemia Pathway 0.226918 0.644
R-HSA-5357905 Regulation of TNFR1 signaling 0.065124 1.186
R-HSA-169893 Prolonged ERK activation events 0.045903 1.338
R-HSA-75893 TNF signaling 0.096222 1.017
R-HSA-9692913 SARS-CoV-1-mediated effects on programmed cell death 0.096735 1.014
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.211364 0.675
R-HSA-8856828 Clathrin-mediated endocytosis 0.058192 1.235
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.169868 0.770
R-HSA-5687128 MAPK6/MAPK4 signaling 0.210312 0.677
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.054346 1.265
R-HSA-392517 Rap1 signalling 0.063286 1.199
R-HSA-4791275 Signaling by WNT in cancer 0.136526 0.865
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.287716 0.541
R-HSA-75153 Apoptotic execution phase 0.065124 1.186
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.103214 0.986
R-HSA-6794361 Neurexins and neuroligins 0.083149 1.080
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.110327 0.957
R-HSA-5205647 Mitophagy 0.153964 0.813
R-HSA-8875513 MET interacts with TNS proteins 0.081286 1.090
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.096735 1.014
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 0.126861 0.897
R-HSA-3371378 Regulation by c-FLIP 0.170184 0.769
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.058757 1.231
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.184143 0.735
R-HSA-9693928 Defective RIPK1-mediated regulated necrosis 0.197869 0.704
R-HSA-4839744 Signaling by APC mutants 0.211364 0.675
R-HSA-4839748 Signaling by AMER1 mutants 0.224633 0.649
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.250508 0.601
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.250508 0.601
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.062316 1.205
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.275522 0.560
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.275522 0.560
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.287716 0.541
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.299705 0.523
R-HSA-8875878 MET promotes cell motility 0.177820 0.750
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.196062 0.708
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.202195 0.694
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.102232 0.990
R-HSA-69473 G2/M DNA damage checkpoint 0.163757 0.786
R-HSA-73893 DNA Damage Bypass 0.251839 0.599
R-HSA-397795 G-protein beta:gamma signalling 0.142289 0.847
R-HSA-170968 Frs2-mediated activation 0.250508 0.601
R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis 0.155986 0.807
R-HSA-9620244 Long-term potentiation 0.097908 1.009
R-HSA-3295583 TRP channels 0.103214 0.986
R-HSA-212165 Epigenetic regulation of gene expression 0.229256 0.640
R-HSA-9824272 Somitogenesis 0.226918 0.644
R-HSA-6807004 Negative regulation of MET activity 0.067930 1.168
R-HSA-5675221 Negative regulation of MAPK pathway 0.051672 1.287
R-HSA-187687 Signalling to ERKs 0.159870 0.796
R-HSA-390648 Muscarinic acetylcholine receptors 0.111925 0.951
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.184143 0.735
R-HSA-9761174 Formation of intermediate mesoderm 0.197869 0.704
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.263121 0.580
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 0.275522 0.560
R-HSA-6811438 Intra-Golgi traffic 0.202195 0.694
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.133241 0.875
R-HSA-912446 Meiotic recombination 0.264332 0.578
R-HSA-157118 Signaling by NOTCH 0.280596 0.552
R-HSA-162599 Late Phase of HIV Life Cycle 0.137998 0.860
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.110327 0.957
R-HSA-9960525 CASP5-mediated substrate cleavage 0.081286 1.090
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 0.111925 0.951
R-HSA-187706 Signalling to p38 via RIT and RIN 0.126861 0.897
R-HSA-69416 Dimerization of procaspase-8 0.170184 0.769
R-HSA-9706019 RHOBTB3 ATPase cycle 0.211364 0.675
R-HSA-5689901 Metalloprotease DUBs 0.103214 0.986
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.114052 0.943
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.299705 0.523
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.299705 0.523
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.311492 0.507
R-HSA-168325 Viral Messenger RNA Synthesis 0.113647 0.944
R-HSA-6794362 Protein-protein interactions at synapses 0.075073 1.125
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.132166 0.879
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.205960 0.686
R-HSA-9909396 Circadian clock 0.243882 0.613
R-HSA-9609690 HCMV Early Events 0.301719 0.520
R-HSA-9645723 Diseases of programmed cell death 0.227915 0.642
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.241294 0.617
R-HSA-180786 Extension of Telomeres 0.314186 0.503
R-HSA-73887 Death Receptor Signaling 0.074620 1.127
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.314186 0.503
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.202195 0.694
R-HSA-9843745 Adipogenesis 0.240246 0.619
R-HSA-68886 M Phase 0.084396 1.074
R-HSA-111469 SMAC, XIAP-regulated apoptotic response 0.126861 0.897
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.239362 0.621
R-HSA-157858 Gap junction trafficking and regulation 0.251839 0.599
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.170472 0.768
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.141547 0.849
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.077371 1.111
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.196062 0.708
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.127339 0.895
R-HSA-5653656 Vesicle-mediated transport 0.171029 0.767
R-HSA-162587 HIV Life Cycle 0.079515 1.100
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.103214 0.986
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.300446 0.522
R-HSA-9675135 Diseases of DNA repair 0.065124 1.186
R-HSA-68875 Mitotic Prophase 0.194319 0.711
R-HSA-9609646 HCMV Infection 0.309724 0.509
R-HSA-9009391 Extra-nuclear estrogen signaling 0.124430 0.905
R-HSA-6806834 Signaling by MET 0.064115 1.193
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.065573 1.183
R-HSA-9960519 CASP4-mediated substrate cleavage 0.081286 1.090
R-HSA-111463 SMAC (DIABLO) binds to IAPs 0.111925 0.951
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.155986 0.807
R-HSA-444257 RSK activation 0.170184 0.769
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.184143 0.735
R-HSA-140342 Apoptosis induced DNA fragmentation 0.197869 0.704
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.077539 1.110
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.097908 1.009
R-HSA-177243 Interactions of Rev with host cellular proteins 0.046713 1.331
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.046713 1.331
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.049162 1.308
R-HSA-69091 Polymerase switching 0.237680 0.624
R-HSA-69109 Leading Strand Synthesis 0.237680 0.624
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.250508 0.601
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.275522 0.560
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.275522 0.560
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.287716 0.541
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.183872 0.735
R-HSA-177929 Signaling by EGFR 0.096222 1.017
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.097908 1.009
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.125167 0.903
R-HSA-162906 HIV Infection 0.243784 0.613
R-HSA-430116 GP1b-IX-V activation signalling 0.184143 0.735
R-HSA-8856688 Golgi-to-ER retrograde transport 0.243882 0.613
R-HSA-2559583 Cellular Senescence 0.250221 0.602
R-HSA-1640170 Cell Cycle 0.073044 1.136
R-HSA-162592 Integration of provirus 0.224633 0.649
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.148103 0.829
R-HSA-983189 Kinesins 0.110071 0.958
R-HSA-69278 Cell Cycle, Mitotic 0.127951 0.893
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.188772 0.724
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.126861 0.897
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.237680 0.624
R-HSA-9697154 Disorders of Nervous System Development 0.237680 0.624
R-HSA-9005895 Pervasive developmental disorders 0.237680 0.624
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.250508 0.601
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.065124 1.186
R-HSA-399956 CRMPs in Sema3A signaling 0.263121 0.580
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.263121 0.580
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.275522 0.560
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.287716 0.541
R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.311492 0.507
R-HSA-5578749 Transcriptional regulation by small RNAs 0.155655 0.808
R-HSA-352230 Amino acid transport across the plasma membrane 0.314186 0.503
R-HSA-2559580 Oxidative Stress Induced Senescence 0.300446 0.522
R-HSA-1295596 Spry regulation of FGF signaling 0.275522 0.560
R-HSA-3214841 PKMTs methylate histone lysines 0.196062 0.708
R-HSA-9007101 Rab regulation of trafficking 0.184138 0.735
R-HSA-5688426 Deubiquitination 0.188710 0.724
R-HSA-1483255 PI Metabolism 0.300446 0.522
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.087544 1.058
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.263121 0.580
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.275522 0.560
R-HSA-9675151 Disorders of Developmental Biology 0.299705 0.523
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.283071 0.548
R-HSA-8878171 Transcriptional regulation by RUNX1 0.241013 0.618
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.196062 0.708
R-HSA-4839726 Chromatin organization 0.175179 0.757
R-HSA-5617833 Cilium Assembly 0.282175 0.549
R-HSA-73857 RNA Polymerase II Transcription 0.246318 0.609
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.225835 0.646
R-HSA-1483249 Inositol phosphate metabolism 0.161118 0.793
R-HSA-2980766 Nuclear Envelope Breakdown 0.099613 1.002
R-HSA-438064 Post NMDA receptor activation events 0.223487 0.651
R-HSA-8939211 ESR-mediated signaling 0.149462 0.825
R-HSA-388479 Vasopressin-like receptors 0.096735 1.014
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.275522 0.560
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.110071 0.958
R-HSA-6784531 tRNA processing in the nucleus 0.117268 0.931
R-HSA-1489509 DAG and IP3 signaling 0.226918 0.644
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.204670 0.689
R-HSA-3247509 Chromatin modifying enzymes 0.143330 0.844
R-HSA-3371556 Cellular response to heat stress 0.197751 0.704
R-HSA-9012852 Signaling by NOTCH3 0.289310 0.539
R-HSA-9705683 SARS-CoV-2-host interactions 0.062757 1.202
R-HSA-5621481 C-type lectin receptors (CLRs) 0.222330 0.653
R-HSA-212436 Generic Transcription Pathway 0.275737 0.560
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.070315 1.153
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.155986 0.807
R-HSA-8849932 Synaptic adhesion-like molecules 0.058757 1.231
R-HSA-2672351 Stimuli-sensing channels 0.148473 0.828
R-HSA-9707616 Heme signaling 0.117268 0.931
R-HSA-983712 Ion channel transport 0.278941 0.554
R-HSA-9686114 Non-canonical inflammasome activation 0.263121 0.580
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.287716 0.541
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.159690 0.797
R-HSA-194138 Signaling by VEGF 0.091695 1.038
R-HSA-9006925 Intracellular signaling by second messengers 0.164942 0.783
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.125167 0.903
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.311492 0.507
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.272966 0.564
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.110546 0.956
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.110546 0.956
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.147684 0.831
R-HSA-9018519 Estrogen-dependent gene expression 0.262240 0.581
R-HSA-5683826 Surfactant metabolism 0.220713 0.656
R-HSA-5633007 Regulation of TP53 Activity 0.186792 0.729
R-HSA-9006931 Signaling by Nuclear Receptors 0.205444 0.687
R-HSA-1257604 PIP3 activates AKT signaling 0.288059 0.541
R-HSA-2028269 Signaling by Hippo 0.054346 1.265
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.103214 0.986
R-HSA-9842663 Signaling by LTK 0.237680 0.624
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.311492 0.507
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.233013 0.633
R-HSA-166520 Signaling by NTRKs 0.311019 0.507
R-HSA-70171 Glycolysis 0.291263 0.536
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.288354 0.540
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.224633 0.649
R-HSA-354192 Integrin signaling 0.142289 0.847
R-HSA-9031628 NGF-stimulated transcription 0.245597 0.610
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.160846 0.794
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.103214 0.986
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.219077 0.659
R-HSA-2262752 Cellular responses to stress 0.311229 0.507
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.226918 0.644
R-HSA-446728 Cell junction organization 0.136923 0.864
R-HSA-418990 Adherens junctions interactions 0.219208 0.659
R-HSA-421270 Cell-cell junction organization 0.312667 0.505
R-HSA-6804757 Regulation of TP53 Degradation 0.165816 0.780
R-HSA-3700989 Transcriptional Regulation by TP53 0.205704 0.687
R-HSA-1500931 Cell-Cell communication 0.213580 0.670
R-HSA-1169408 ISG15 antiviral mechanism 0.167855 0.775
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.245597 0.610
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.183872 0.735
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.153964 0.813
R-HSA-9694516 SARS-CoV-2 Infection 0.177995 0.750
R-HSA-381038 XBP1(S) activates chaperone genes 0.079704 1.099
R-HSA-193704 p75 NTR receptor-mediated signalling 0.286679 0.543
R-HSA-8986944 Transcriptional Regulation by MECP2 0.241294 0.617
R-HSA-381070 IRE1alpha activates chaperones 0.094424 1.025
R-HSA-9833110 RSV-host interactions 0.314247 0.503
R-HSA-381119 Unfolded Protein Response (UPR) 0.128019 0.893
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.323083 0.491
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.323083 0.491
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.323083 0.491
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.323083 0.491
R-HSA-111471 Apoptotic factor-mediated response 0.323083 0.491
R-HSA-5358508 Mismatch Repair 0.323083 0.491
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.323083 0.491
R-HSA-73856 RNA Polymerase II Transcription Termination 0.326557 0.486
R-HSA-9793380 Formation of paraxial mesoderm 0.326557 0.486
R-HSA-112043 PLC beta mediated events 0.326557 0.486
R-HSA-211000 Gene Silencing by RNA 0.328063 0.484
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.334478 0.476
R-HSA-110320 Translesion Synthesis by POLH 0.334478 0.476
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.334478 0.476
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.334478 0.476
R-HSA-912631 Regulation of signaling by CBL 0.334478 0.476
R-HSA-449836 Other interleukin signaling 0.334478 0.476
R-HSA-1834941 STING mediated induction of host immune responses 0.334478 0.476
R-HSA-1989781 PPARA activates gene expression 0.337662 0.472
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.338868 0.470
R-HSA-9612973 Autophagy 0.341478 0.467
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.345296 0.462
R-HSA-9610379 HCMV Late Events 0.345296 0.462
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.345683 0.461
R-HSA-1181150 Signaling by NODAL 0.345683 0.461
R-HSA-1852241 Organelle biogenesis and maintenance 0.355462 0.449
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.355667 0.449
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.356700 0.448
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.356700 0.448
R-HSA-69186 Lagging Strand Synthesis 0.356700 0.448
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.356700 0.448
R-HSA-210991 Basigin interactions 0.356700 0.448
R-HSA-162594 Early Phase of HIV Life Cycle 0.356700 0.448
R-HSA-5693606 DNA Double Strand Break Response 0.363274 0.440
R-HSA-9958863 SLC-mediated transport of amino acids 0.363274 0.440
R-HSA-112040 G-protein mediated events 0.363274 0.440
R-HSA-109581 Apoptosis 0.364391 0.438
R-HSA-74160 Gene expression (Transcription) 0.365157 0.438
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.367532 0.435
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.367532 0.435
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.367532 0.435
R-HSA-947581 Molybdenum cofactor biosynthesis 0.367532 0.435
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.367532 0.435
R-HSA-175474 Assembly Of The HIV Virion 0.367532 0.435
R-HSA-8949215 Mitochondrial calcium ion transport 0.367532 0.435
R-HSA-5218859 Regulated Necrosis 0.369323 0.433
R-HSA-68882 Mitotic Anaphase 0.371355 0.430
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.374692 0.426
R-HSA-6803529 FGFR2 alternative splicing 0.378182 0.422
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.378182 0.422
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.378182 0.422
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.378182 0.422
R-HSA-373760 L1CAM interactions 0.378562 0.422
R-HSA-8953854 Metabolism of RNA 0.380665 0.419
R-HSA-204005 COPII-mediated vesicle transport 0.381354 0.419
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.381354 0.419
R-HSA-70326 Glucose metabolism 0.383123 0.417
R-HSA-5619102 SLC transporter disorders 0.383464 0.416
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.387334 0.412
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.388653 0.410
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.388653 0.410
R-HSA-977068 Termination of O-glycan biosynthesis 0.388653 0.410
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.388653 0.410
R-HSA-9830674 Formation of the ureteric bud 0.388653 0.410
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.393287 0.405
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.393287 0.405
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.398949 0.399
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.398949 0.399
R-HSA-8863678 Neurodegenerative Diseases 0.398949 0.399
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.398949 0.399
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.398949 0.399
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.405115 0.392
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.405265 0.392
R-HSA-9932451 SWI/SNF chromatin remodelers 0.409072 0.388
R-HSA-9932444 ATP-dependent chromatin remodelers 0.409072 0.388
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.409072 0.388
R-HSA-3214842 HDMs demethylate histones 0.409072 0.388
R-HSA-5689880 Ub-specific processing proteases 0.410049 0.387
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.413830 0.383
R-HSA-162909 Host Interactions of HIV factors 0.414810 0.382
R-HSA-5689603 UCH proteinases 0.416832 0.380
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.417606 0.379
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.419025 0.378
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.419025 0.378
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.419025 0.378
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.419025 0.378
R-HSA-8953897 Cellular responses to stimuli 0.419441 0.377
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.428811 0.368
R-HSA-445095 Interaction between L1 and Ankyrins 0.428811 0.368
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.428811 0.368
R-HSA-73863 RNA Polymerase I Transcription Termination 0.428811 0.368
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.428811 0.368
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.428811 0.368
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.428811 0.368
R-HSA-69481 G2/M Checkpoints 0.432688 0.364
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.434187 0.362
R-HSA-113418 Formation of the Early Elongation Complex 0.438433 0.358
R-HSA-5620971 Pyroptosis 0.438433 0.358
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.438433 0.358
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.438433 0.358
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.438433 0.358
R-HSA-9638334 Iron assimilation using enterobactin 0.438433 0.358
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.439911 0.357
R-HSA-5693607 Processing of DNA double-strand break ends 0.445602 0.351
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.445602 0.351
R-HSA-72086 mRNA Capping 0.447893 0.349
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.447893 0.349
R-HSA-9615710 Late endosomal microautophagy 0.447893 0.349
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.447893 0.349
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.447893 0.349
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.447893 0.349
R-HSA-418360 Platelet calcium homeostasis 0.447893 0.349
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.447893 0.349
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.451262 0.346
R-HSA-9707564 Cytoprotection by HMOX1 0.456889 0.340
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.457195 0.340
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.462482 0.335
R-HSA-162588 Budding and maturation of HIV virion 0.466340 0.331
R-HSA-182971 EGFR downregulation 0.466340 0.331
R-HSA-399719 Trafficking of AMPA receptors 0.466340 0.331
R-HSA-186763 Downstream signal transduction 0.466340 0.331
R-HSA-1500620 Meiosis 0.468042 0.330
R-HSA-69190 DNA strand elongation 0.475332 0.323
R-HSA-9675126 Diseases of mitotic cell cycle 0.475332 0.323
R-HSA-1538133 G0 and Early G1 0.475332 0.323
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.480733 0.318
R-HSA-5675482 Regulation of necroptotic cell death 0.484173 0.315
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.484173 0.315
R-HSA-9930044 Nuclear RNA decay 0.484173 0.315
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.484173 0.315
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.484173 0.315
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.484173 0.315
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.484173 0.315
R-HSA-9022692 Regulation of MECP2 expression and activity 0.484173 0.315
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.485018 0.314
R-HSA-9663891 Selective autophagy 0.489934 0.310
R-HSA-390522 Striated Muscle Contraction 0.492865 0.307
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.492865 0.307
R-HSA-114508 Effects of PIP2 hydrolysis 0.492865 0.307
R-HSA-9664417 Leishmania phagocytosis 0.497744 0.303
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.497744 0.303
R-HSA-9664407 Parasite infection 0.497744 0.303
R-HSA-73884 Base Excision Repair 0.500667 0.300
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.501412 0.300
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.501412 0.300
R-HSA-168638 NOD1/2 Signaling Pathway 0.501412 0.300
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.501951 0.299
R-HSA-1632852 Macroautophagy 0.501951 0.299
R-HSA-69620 Cell Cycle Checkpoints 0.508945 0.293
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.509815 0.293
R-HSA-381042 PERK regulates gene expression 0.509815 0.293
R-HSA-9679506 SARS-CoV Infections 0.514146 0.289
R-HSA-212300 PRC2 methylates histones and DNA 0.518076 0.286
R-HSA-114604 GPVI-mediated activation cascade 0.518076 0.286
R-HSA-111933 Calmodulin induced events 0.518076 0.286
R-HSA-111997 CaM pathway 0.518076 0.286
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.520142 0.284
R-HSA-4641257 Degradation of AXIN 0.526200 0.279
R-HSA-427359 SIRT1 negatively regulates rRNA expression 0.526200 0.279
R-HSA-4641258 Degradation of DVL 0.526200 0.279
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.526200 0.279
R-HSA-5689896 Ovarian tumor domain proteases 0.526200 0.279
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.529222 0.276
R-HSA-5357801 Programmed Cell Death 0.530648 0.275
R-HSA-199977 ER to Golgi Anterograde Transport 0.530883 0.275
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.534186 0.272
R-HSA-69242 S Phase 0.534940 0.272
R-HSA-9758941 Gastrulation 0.538977 0.268
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.542039 0.266
R-HSA-69541 Stabilization of p53 0.542039 0.266
R-HSA-8953750 Transcriptional Regulation by E2F6 0.542039 0.266
R-HSA-6807878 COPI-mediated anterograde transport 0.542121 0.266
R-HSA-9856651 MITF-M-dependent gene expression 0.542994 0.265
R-HSA-157579 Telomere Maintenance 0.547133 0.262
R-HSA-8878159 Transcriptional regulation by RUNX3 0.547133 0.262
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.549759 0.260
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.549759 0.260
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.549759 0.260
R-HSA-167169 HIV Transcription Elongation 0.549759 0.260
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.549759 0.260
R-HSA-71240 Tryptophan catabolism 0.549759 0.260
R-HSA-9614085 FOXO-mediated transcription 0.557041 0.254
R-HSA-3214847 HATs acetylate histones 0.557041 0.254
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.557350 0.254
R-HSA-9607240 FLT3 Signaling 0.557350 0.254
R-HSA-9694548 Maturation of spike protein 0.557350 0.254
R-HSA-8853884 Transcriptional Regulation by VENTX 0.557350 0.254
R-HSA-76002 Platelet activation, signaling and aggregation 0.558343 0.253
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.558857 0.253
R-HSA-69618 Mitotic Spindle Checkpoint 0.561937 0.250
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.562771 0.250
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.564814 0.248
R-HSA-167161 HIV Transcription Initiation 0.564814 0.248
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.564814 0.248
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.564814 0.248
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.572152 0.242
R-HSA-110329 Cleavage of the damaged pyrimidine 0.572152 0.242
R-HSA-73928 Depyrimidination 0.572152 0.242
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.572152 0.242
R-HSA-111996 Ca-dependent events 0.572152 0.242
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.572152 0.242
R-HSA-73776 RNA Polymerase II Promoter Escape 0.579367 0.237
R-HSA-9710421 Defective pyroptosis 0.579367 0.237
R-HSA-5654743 Signaling by FGFR4 0.579367 0.237
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.579367 0.237
R-HSA-1433557 Signaling by SCF-KIT 0.579367 0.237
R-HSA-111885 Opioid Signalling 0.581135 0.236
R-HSA-8951664 Neddylation 0.584668 0.233
R-HSA-190828 Gap junction trafficking 0.586460 0.232
R-HSA-3214858 RMTs methylate histone arginines 0.586460 0.232
R-HSA-375280 Amine ligand-binding receptors 0.586460 0.232
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.590500 0.229
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.593434 0.227
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.593434 0.227
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.593434 0.227
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.593434 0.227
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.593434 0.227
R-HSA-5654741 Signaling by FGFR3 0.593434 0.227
R-HSA-9692914 SARS-CoV-1-host interactions 0.595124 0.225
R-HSA-69239 Synthesis of DNA 0.599709 0.222
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.599709 0.222
R-HSA-9700206 Signaling by ALK in cancer 0.599709 0.222
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.600292 0.222
R-HSA-2299718 Condensation of Prophase Chromosomes 0.600292 0.222
R-HSA-9861718 Regulation of pyruvate metabolism 0.600292 0.222
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.604255 0.219
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.607034 0.217
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.613230 0.212
R-HSA-166166 MyD88-independent TLR4 cascade 0.613230 0.212
R-HSA-389356 Co-stimulation by CD28 0.613662 0.212
R-HSA-9766229 Degradation of CDH1 0.620179 0.207
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.620179 0.207
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.620179 0.207
R-HSA-72306 tRNA processing 0.622451 0.206
R-HSA-195721 Signaling by WNT 0.627502 0.202
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.629509 0.201
R-HSA-72187 mRNA 3'-end processing 0.639081 0.194
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.639081 0.194
R-HSA-73772 RNA Polymerase I Promoter Escape 0.639081 0.194
R-HSA-1280218 Adaptive Immune System 0.639113 0.194
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.639221 0.194
R-HSA-9678108 SARS-CoV-1 Infection 0.639926 0.194
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.643417 0.192
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.645171 0.190
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.645171 0.190
R-HSA-445355 Smooth Muscle Contraction 0.645171 0.190
R-HSA-9639288 Amino acids regulate mTORC1 0.645171 0.190
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.651158 0.186
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.651158 0.186
R-HSA-1592230 Mitochondrial biogenesis 0.651695 0.186
R-HSA-168255 Influenza Infection 0.653494 0.185
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.657045 0.182
R-HSA-3214815 HDACs deacetylate histones 0.657045 0.182
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.662833 0.179
R-HSA-5578775 Ion homeostasis 0.662833 0.179
R-HSA-193648 NRAGE signals death through JNK 0.662833 0.179
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.662833 0.179
R-HSA-5654736 Signaling by FGFR1 0.662833 0.179
R-HSA-5619115 Disorders of transmembrane transporters 0.664298 0.178
R-HSA-201681 TCF dependent signaling in response to WNT 0.666694 0.176
R-HSA-73886 Chromosome Maintenance 0.667791 0.175
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.667791 0.175
R-HSA-9824446 Viral Infection Pathways 0.668049 0.175
R-HSA-5621480 Dectin-2 family 0.668524 0.175
R-HSA-9764561 Regulation of CDH1 Function 0.668524 0.175
R-HSA-1643685 Disease 0.671303 0.173
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.674118 0.171
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.674118 0.171
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.674118 0.171
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.675612 0.170
R-HSA-2132295 MHC class II antigen presentation 0.675612 0.170
R-HSA-69275 G2/M Transition 0.676353 0.170
R-HSA-6809371 Formation of the cornified envelope 0.679467 0.168
R-HSA-429914 Deadenylation-dependent mRNA decay 0.679619 0.168
R-HSA-186712 Regulation of beta-cell development 0.679619 0.168
R-HSA-453274 Mitotic G2-G2/M phases 0.682676 0.166
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.685027 0.164
R-HSA-8943724 Regulation of PTEN gene transcription 0.685027 0.164
R-HSA-5362517 Signaling by Retinoic Acid 0.685027 0.164
R-HSA-388841 Regulation of T cell activation by CD28 family 0.689321 0.162
R-HSA-450294 MAP kinase activation 0.690345 0.161
R-HSA-445717 Aquaporin-mediated transport 0.690345 0.161
R-HSA-168898 Toll-like Receptor Cascades 0.691990 0.160
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.695572 0.158
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.695572 0.158
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.695572 0.158
R-HSA-186797 Signaling by PDGF 0.695572 0.158
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.695572 0.158
R-HSA-68877 Mitotic Prometaphase 0.698084 0.156
R-HSA-373755 Semaphorin interactions 0.700712 0.154
R-HSA-69615 G1/S DNA Damage Checkpoints 0.700712 0.154
R-HSA-8848021 Signaling by PTK6 0.700712 0.154
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.700712 0.154
R-HSA-936837 Ion transport by P-type ATPases 0.705766 0.151
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.705766 0.151
R-HSA-1474165 Reproduction 0.708972 0.149
R-HSA-389948 Co-inhibition by PD-1 0.718696 0.143
R-HSA-9830369 Kidney development 0.720422 0.142
R-HSA-9711123 Cellular response to chemical stress 0.720598 0.142
R-HSA-948021 Transport to the Golgi and subsequent modification 0.724382 0.140
R-HSA-913709 O-linked glycosylation of mucins 0.725143 0.140
R-HSA-167172 Transcription of the HIV genome 0.725143 0.140
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.725143 0.140
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.734350 0.134
R-HSA-448424 Interleukin-17 signaling 0.734350 0.134
R-HSA-69202 Cyclin E associated events during G1/S transition 0.734350 0.134
R-HSA-453276 Regulation of mitotic cell cycle 0.738837 0.131
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.738837 0.131
R-HSA-427413 NoRC negatively regulates rRNA expression 0.738837 0.131
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.738837 0.131
R-HSA-9638482 Metal ion assimilation from the host 0.738837 0.131
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.743249 0.129
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.743249 0.129
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.747587 0.126
R-HSA-69052 Switching of origins to a post-replicative state 0.747587 0.126
R-HSA-4086398 Ca2+ pathway 0.747587 0.126
R-HSA-9658195 Leishmania infection 0.751799 0.124
R-HSA-9824443 Parasitic Infection Pathways 0.751799 0.124
R-HSA-9013694 Signaling by NOTCH4 0.751851 0.124
R-HSA-397014 Muscle contraction 0.754064 0.123
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.754064 0.123
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.756044 0.121
R-HSA-9730414 MITF-M-regulated melanocyte development 0.756631 0.121
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.760166 0.119
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.764219 0.117
R-HSA-9694635 Translation of Structural Proteins 0.764219 0.117
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.767124 0.115
R-HSA-383280 Nuclear Receptor transcription pathway 0.768204 0.115
R-HSA-73864 RNA Polymerase I Transcription 0.768204 0.115
R-HSA-416482 G alpha (12/13) signalling events 0.768204 0.115
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.772922 0.112
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.775973 0.110
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.781383 0.107
R-HSA-69306 DNA Replication 0.786870 0.104
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.787142 0.104
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.790741 0.102
R-HSA-141424 Amplification of signal from the kinetochores 0.797757 0.098
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.797757 0.098
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.800061 0.097
R-HSA-390466 Chaperonin-mediated protein folding 0.804539 0.094
R-HSA-70268 Pyruvate metabolism 0.804539 0.094
R-HSA-202424 Downstream TCR signaling 0.814289 0.089
R-HSA-112310 Neurotransmitter release cycle 0.814289 0.089
R-HSA-2467813 Separation of Sister Chromatids 0.814933 0.089
R-HSA-391251 Protein folding 0.823554 0.084
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.823554 0.084
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.826539 0.083
R-HSA-68867 Assembly of the pre-replicative complex 0.826539 0.083
R-HSA-9837999 Mitochondrial protein degradation 0.829474 0.081
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.832359 0.080
R-HSA-112315 Transmission across Chemical Synapses 0.834460 0.079
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.837985 0.077
R-HSA-112316 Neuronal System 0.838062 0.077
R-HSA-597592 Post-translational protein modification 0.838066 0.077
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.840726 0.075
R-HSA-8957275 Post-translational protein phosphorylation 0.843422 0.074
R-HSA-422356 Regulation of insulin secretion 0.843422 0.074
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.843422 0.074
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.843422 0.074
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.843422 0.074
R-HSA-9842860 Regulation of endogenous retroelements 0.853757 0.069
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.856232 0.067
R-HSA-9860931 Response of endothelial cells to shear stress 0.858666 0.066
R-HSA-3781865 Diseases of glycosylation 0.859503 0.066
R-HSA-5619507 Activation of HOX genes during differentiation 0.861059 0.065
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.861059 0.065
R-HSA-5663205 Infectious disease 0.862302 0.064
R-HSA-418346 Platelet homeostasis 0.865725 0.063
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.867998 0.061
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.870234 0.060
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.872432 0.059
R-HSA-69002 DNA Replication Pre-Initiation 0.872432 0.059
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.872432 0.059
R-HSA-202403 TCR signaling 0.874592 0.058
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.878805 0.056
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.878805 0.056
R-HSA-2871796 FCERI mediated MAPK activation 0.878805 0.056
R-HSA-109582 Hemostasis 0.879146 0.056
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.880858 0.055
R-HSA-9855142 Cellular responses to mechanical stimuli 0.882876 0.054
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.884861 0.053
R-HSA-2029485 Role of phospholipids in phagocytosis 0.888729 0.051
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.896083 0.048
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.896083 0.048
R-HSA-6805567 Keratinization 0.896918 0.047
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.899576 0.046
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.901278 0.045
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.901278 0.045
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 0.902952 0.044
R-HSA-1483257 Phospholipid metabolism 0.903477 0.044
R-HSA-69206 G1/S Transition 0.907805 0.042
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.909368 0.041
R-HSA-114608 Platelet degranulation 0.910905 0.041
R-HSA-913531 Interferon Signaling 0.912776 0.040
R-HSA-5576891 Cardiac conduction 0.918209 0.037
R-HSA-9717189 Sensory perception of taste 0.918209 0.037
R-HSA-1474228 Degradation of the extracellular matrix 0.919597 0.036
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.920961 0.036
R-HSA-168249 Innate Immune System 0.923591 0.035
R-HSA-163685 Integration of energy metabolism 0.926190 0.033
R-HSA-3858494 Beta-catenin independent WNT signaling 0.926190 0.033
R-HSA-5173105 O-linked glycosylation 0.927443 0.033
R-HSA-5368287 Mitochondrial translation 0.928674 0.032
R-HSA-6807070 PTEN Regulation 0.929885 0.032
R-HSA-2871837 FCERI mediated NF-kB activation 0.936731 0.028
R-HSA-9679191 Potential therapeutics for SARS 0.942910 0.026
R-HSA-9711097 Cellular response to starvation 0.950224 0.022
R-HSA-877300 Interferon gamma signaling 0.951070 0.022
R-HSA-9006936 Signaling by TGFB family members 0.951901 0.021
R-HSA-9734767 Developmental Cell Lineages 0.953499 0.021
R-HSA-416476 G alpha (q) signalling events 0.954158 0.020
R-HSA-9664433 Leishmania parasite growth and survival 0.962168 0.017
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.962168 0.017
R-HSA-1280215 Cytokine Signaling in Immune system 0.962518 0.017
R-HSA-6798695 Neutrophil degranulation 0.962519 0.017
R-HSA-449147 Signaling by Interleukins 0.964120 0.016
R-HSA-422475 Axon guidance 0.964452 0.016
R-HSA-375276 Peptide ligand-binding receptors 0.969735 0.013
R-HSA-1266738 Developmental Biology 0.970417 0.013
R-HSA-9675108 Nervous system development 0.976599 0.010
R-HSA-418594 G alpha (i) signalling events 0.976878 0.010
R-HSA-376176 Signaling by ROBO receptors 0.977401 0.010
R-HSA-9640148 Infection with Enterobacteria 0.977401 0.010
R-HSA-8957322 Metabolism of steroids 0.980843 0.008
R-HSA-446203 Asparagine N-linked glycosylation 0.981063 0.008
R-HSA-168256 Immune System 0.982977 0.007
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.986040 0.006
R-HSA-392499 Metabolism of proteins 0.987166 0.006
R-HSA-202733 Cell surface interactions at the vascular wall 0.987626 0.005
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.987877 0.005
R-HSA-382551 Transport of small molecules 0.989266 0.005
R-HSA-9824439 Bacterial Infection Pathways 0.992989 0.003
R-HSA-388396 GPCR downstream signalling 0.993211 0.003
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.993403 0.003
R-HSA-425407 SLC-mediated transmembrane transport 0.993698 0.003
R-HSA-5668914 Diseases of metabolism 0.996020 0.002
R-HSA-72766 Translation 0.996141 0.002
R-HSA-372790 Signaling by GPCR 0.997510 0.001
R-HSA-1474244 Extracellular matrix organization 0.997562 0.001
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.997950 0.001
R-HSA-196854 Metabolism of vitamins and cofactors 0.998625 0.001
R-HSA-500792 GPCR ligand binding 0.999690 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 0.999984 0.000
R-HSA-556833 Metabolism of lipids 0.999998 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 -0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.826 0.168 2 0.278
CLK3CLK3 0.825 0.237 1 0.823
NDR2NDR2 0.820 0.101 -3 0.868
PIM3PIM3 0.820 0.152 -3 0.872
MOSMOS 0.814 0.149 1 0.889
CDC7CDC7 0.814 0.042 1 0.868
SKMLCKSKMLCK 0.814 0.184 -2 0.898
CLK2CLK2 0.812 0.276 -3 0.812
PIM1PIM1 0.811 0.142 -3 0.842
NDR1NDR1 0.810 0.081 -3 0.869
CAMK1BCAMK1B 0.810 0.125 -3 0.890
RSK2RSK2 0.809 0.121 -3 0.836
FAM20CFAM20C 0.809 0.019 2 0.228
PRKD1PRKD1 0.808 0.073 -3 0.870
CDKL1CDKL1 0.805 0.098 -3 0.857
P90RSKP90RSK 0.805 0.100 -3 0.839
MTORMTOR 0.805 0.093 1 0.764
RAF1RAF1 0.804 0.104 1 0.810
PRKD2PRKD2 0.803 0.081 -3 0.836
SRPK1SRPK1 0.803 0.113 -3 0.821
HUNKHUNK 0.803 0.092 2 0.285
CAMK2ACAMK2A 0.803 0.123 2 0.291
RSK4RSK4 0.802 0.130 -3 0.811
NUAK2NUAK2 0.802 0.100 -3 0.884
CAMK2BCAMK2B 0.802 0.090 2 0.267
DYRK4DYRK4 0.802 0.207 1 0.644
PKN3PKN3 0.802 0.035 -3 0.868
CAMK2GCAMK2G 0.802 -0.005 2 0.248
CDKL5CDKL5 0.802 0.070 -3 0.859
HIPK4HIPK4 0.801 0.058 1 0.782
PRPKPRPK 0.801 -0.051 -1 0.838
RSK3RSK3 0.800 0.076 -3 0.823
LATS2LATS2 0.799 0.026 -5 0.767
PKN2PKN2 0.799 0.073 -3 0.871
MSK1MSK1 0.799 0.142 -3 0.812
DYRK2DYRK2 0.799 0.129 1 0.707
RIPK3RIPK3 0.799 0.066 3 0.770
P70S6KBP70S6KB 0.798 0.077 -3 0.848
GRK1GRK1 0.798 0.078 -2 0.835
IKKBIKKB 0.798 0.006 -2 0.761
NLKNLK 0.798 -0.002 1 0.821
DSTYKDSTYK 0.798 0.046 2 0.286
CAMLCKCAMLCK 0.798 0.085 -2 0.883
MARK4MARK4 0.798 0.039 4 0.842
ERK5ERK5 0.798 0.021 1 0.828
DAPK2DAPK2 0.798 0.101 -3 0.891
AMPKA1AMPKA1 0.798 0.026 -3 0.886
AURCAURC 0.797 0.067 -2 0.702
ICKICK 0.797 0.071 -3 0.885
MST4MST4 0.797 0.003 2 0.212
PKACGPKACG 0.797 0.058 -2 0.794
GCN2GCN2 0.796 -0.128 2 0.195
CAMK2DCAMK2D 0.796 0.028 -3 0.873
ATRATR 0.796 0.013 1 0.821
MAPKAPK2MAPKAPK2 0.796 0.087 -3 0.798
WNK1WNK1 0.795 0.018 -2 0.910
PKCDPKCD 0.795 0.011 2 0.174
PAK1PAK1 0.795 0.036 -2 0.828
MSK2MSK2 0.795 0.087 -3 0.807
NIKNIK 0.795 0.022 -3 0.887
TSSK2TSSK2 0.795 0.043 -5 0.840
CLK4CLK4 0.795 0.148 -3 0.829
PKACBPKACB 0.794 0.105 -2 0.722
PRKXPRKX 0.794 0.122 -3 0.756
PDHK4PDHK4 0.794 -0.125 1 0.821
ULK2ULK2 0.793 -0.150 2 0.166
LATS1LATS1 0.793 0.106 -3 0.868
MYLK4MYLK4 0.792 0.135 -2 0.816
AMPKA2AMPKA2 0.792 0.031 -3 0.866
TSSK1TSSK1 0.792 0.028 -3 0.900
BMPR2BMPR2 0.792 -0.077 -2 0.894
BMPR1BBMPR1B 0.791 0.150 1 0.828
NIM1NIM1 0.791 -0.032 3 0.786
MAPKAPK3MAPKAPK3 0.791 0.040 -3 0.833
KISKIS 0.791 0.029 1 0.701
MASTLMASTL 0.791 -0.052 -2 0.836
BRSK1BRSK1 0.791 0.036 -3 0.835
PASKPASK 0.790 0.259 -3 0.882
TBK1TBK1 0.790 -0.096 1 0.686
CAMK4CAMK4 0.790 0.027 -3 0.854
CLK1CLK1 0.790 0.132 -3 0.811
DRAK1DRAK1 0.790 0.213 1 0.779
SRPK2SRPK2 0.790 0.080 -3 0.754
GRK6GRK6 0.789 0.045 1 0.817
QSKQSK 0.789 0.052 4 0.821
PKCBPKCB 0.788 -0.004 2 0.162
PKCGPKCG 0.788 -0.001 2 0.177
IKKAIKKA 0.788 -0.013 -2 0.747
JNK2JNK2 0.788 0.114 1 0.633
GRK5GRK5 0.787 -0.070 -3 0.826
PAK3PAK3 0.787 -0.011 -2 0.825
MNK1MNK1 0.787 0.034 -2 0.837
MARK3MARK3 0.787 0.086 4 0.778
NEK6NEK6 0.786 -0.104 -2 0.858
CAMK1GCAMK1G 0.786 0.095 -3 0.821
DLKDLK 0.786 0.046 1 0.802
IKKEIKKE 0.786 -0.080 1 0.682
MLK1MLK1 0.786 -0.096 2 0.206
AKT2AKT2 0.786 0.105 -3 0.770
ULK1ULK1 0.786 -0.143 -3 0.810
PKCAPKCA 0.785 -0.016 2 0.149
TGFBR2TGFBR2 0.785 -0.076 -2 0.797
MNK2MNK2 0.785 0.010 -2 0.825
PRKD3PRKD3 0.785 0.047 -3 0.806
PIM2PIM2 0.785 0.093 -3 0.816
RIPK1RIPK1 0.785 -0.022 1 0.772
CDK18CDK18 0.785 0.048 1 0.635
CDK7CDK7 0.784 0.012 1 0.700
MELKMELK 0.784 -0.004 -3 0.853
BCKDKBCKDK 0.784 -0.092 -1 0.822
CHAK2CHAK2 0.784 -0.074 -1 0.843
NEK7NEK7 0.784 -0.129 -3 0.834
SIKSIK 0.784 0.038 -3 0.809
PDHK1PDHK1 0.784 -0.197 1 0.796
TGFBR1TGFBR1 0.784 0.056 -2 0.811
AURBAURB 0.784 0.039 -2 0.697
ATMATM 0.783 0.032 1 0.761
BRSK2BRSK2 0.783 -0.010 -3 0.852
WNK3WNK3 0.782 -0.149 1 0.778
HIPK1HIPK1 0.782 0.068 1 0.725
SGK3SGK3 0.782 0.057 -3 0.825
MLK2MLK2 0.782 -0.100 2 0.185
JNK3JNK3 0.782 0.089 1 0.666
PAK2PAK2 0.782 -0.005 -2 0.810
MLK3MLK3 0.782 -0.072 2 0.170
QIKQIK 0.782 -0.010 -3 0.862
DCAMKL1DCAMKL1 0.782 0.054 -3 0.833
HIPK2HIPK2 0.782 0.065 1 0.631
NUAK1NUAK1 0.782 0.001 -3 0.839
GRK4GRK4 0.781 -0.052 -2 0.854
AURAAURA 0.781 0.055 -2 0.665
SRPK3SRPK3 0.781 0.062 -3 0.787
DNAPKDNAPK 0.781 0.070 1 0.682
CDK8CDK8 0.781 -0.010 1 0.684
CDK1CDK1 0.780 0.061 1 0.656
PLK4PLK4 0.780 -0.069 2 0.164
PAK6PAK6 0.780 0.004 -2 0.738
GRK7GRK7 0.779 0.047 1 0.759
ANKRD3ANKRD3 0.779 -0.087 1 0.824
PKG2PKG2 0.779 0.031 -2 0.727
ALK4ALK4 0.779 0.005 -2 0.840
MARK1MARK1 0.779 0.049 4 0.798
MARK2MARK2 0.778 0.024 4 0.743
PKCHPKCH 0.778 -0.040 2 0.150
DCAMKL2DCAMKL2 0.778 0.028 -3 0.851
SNRKSNRK 0.778 -0.077 2 0.161
IRE1IRE1 0.778 -0.113 1 0.766
PLK1PLK1 0.778 -0.019 -2 0.805
CDK14CDK14 0.778 0.059 1 0.670
PKCZPKCZ 0.778 -0.041 2 0.162
DYRK3DYRK3 0.777 0.110 1 0.722
CDK19CDK19 0.777 -0.000 1 0.648
DYRK1ADYRK1A 0.777 0.060 1 0.736
MEK1MEK1 0.777 -0.022 2 0.251
PHKG1PHKG1 0.777 -0.062 -3 0.860
CHK1CHK1 0.777 0.018 -3 0.848
TTBK2TTBK2 0.777 -0.155 2 0.152
CDK17CDK17 0.776 0.032 1 0.579
IRE2IRE2 0.776 -0.106 2 0.137
PKACAPKACA 0.776 0.076 -2 0.671
SSTKSSTK 0.776 -0.001 4 0.805
ALK2ALK2 0.776 0.065 -2 0.821
CDK5CDK5 0.776 0.006 1 0.721
NEK9NEK9 0.776 -0.170 2 0.178
DYRK1BDYRK1B 0.775 0.073 1 0.669
CDK10CDK10 0.775 0.064 1 0.659
PLK3PLK3 0.775 0.011 2 0.286
P38AP38A 0.775 0.047 1 0.727
SMMLCKSMMLCK 0.774 0.100 -3 0.862
ACVR2BACVR2B 0.774 0.056 -2 0.799
PKRPKR 0.774 -0.067 1 0.810
P38BP38B 0.774 0.062 1 0.654
MLK4MLK4 0.773 -0.100 2 0.161
YSK4YSK4 0.773 -0.034 1 0.746
CAMK1DCAMK1D 0.773 0.075 -3 0.756
BMPR1ABMPR1A 0.773 0.102 1 0.806
GAKGAK 0.773 0.231 1 0.890
P38GP38G 0.772 0.041 1 0.573
ERK7ERK7 0.771 -0.038 2 0.110
DAPK3DAPK3 0.771 0.099 -3 0.847
CDK13CDK13 0.771 -0.009 1 0.666
CDK16CDK16 0.770 0.040 1 0.597
MST3MST3 0.770 0.029 2 0.241
HIPK3HIPK3 0.770 0.029 1 0.711
VRK2VRK2 0.769 -0.165 1 0.840
ACVR2AACVR2A 0.769 0.005 -2 0.783
P70S6KP70S6K 0.769 0.034 -3 0.780
MPSK1MPSK1 0.769 0.031 1 0.826
CDK3CDK3 0.769 0.047 1 0.603
MEKK3MEKK3 0.769 0.016 1 0.773
CDK2CDK2 0.769 0.007 1 0.728
NEK2NEK2 0.769 -0.126 2 0.166
PRP4PRP4 0.769 0.032 -3 0.777
DAPK1DAPK1 0.768 0.114 -3 0.837
ERK1ERK1 0.768 0.012 1 0.646
GRK2GRK2 0.768 0.000 -2 0.738
AKT1AKT1 0.768 0.053 -3 0.786
CK1ECK1E 0.767 -0.001 -3 0.537
PKCTPKCT 0.767 -0.037 2 0.139
CDK9CDK9 0.766 -0.011 1 0.670
SMG1SMG1 0.766 -0.034 1 0.774
BRAFBRAF 0.766 -0.053 -4 0.855
ERK2ERK2 0.765 -0.007 1 0.676
MAKMAK 0.765 0.100 -2 0.779
CDK12CDK12 0.765 -0.006 1 0.635
CK2A2CK2A2 0.765 0.077 1 0.786
PKCEPKCE 0.764 0.009 2 0.165
TLK2TLK2 0.764 -0.099 1 0.767
SGK1SGK1 0.764 0.088 -3 0.703
P38DP38D 0.763 0.064 1 0.600
GSK3AGSK3A 0.763 0.049 4 0.508
WNK4WNK4 0.763 -0.090 -2 0.897
MAPKAPK5MAPKAPK5 0.763 -0.029 -3 0.786
MEK5MEK5 0.763 -0.133 2 0.211
AKT3AKT3 0.762 0.073 -3 0.720
CHAK1CHAK1 0.762 -0.169 2 0.149
PAK4PAK4 0.762 -0.007 -2 0.677
GSK3BGSK3B 0.762 0.032 4 0.501
IRAK4IRAK4 0.762 -0.116 1 0.760
PKCIPKCI 0.761 -0.042 2 0.152
NEK5NEK5 0.761 -0.084 1 0.803
ZAKZAK 0.761 -0.122 1 0.739
JNK1JNK1 0.760 0.072 1 0.627
LKB1LKB1 0.760 0.002 -3 0.835
PAK5PAK5 0.760 -0.015 -2 0.673
PHKG2PHKG2 0.759 -0.060 -3 0.838
CK2A1CK2A1 0.759 0.089 1 0.767
MEKK2MEKK2 0.759 -0.129 2 0.178
MRCKAMRCKA 0.758 0.077 -3 0.810
SBKSBK 0.758 0.096 -3 0.669
TAO3TAO3 0.758 -0.053 1 0.770
ROCK2ROCK2 0.758 0.066 -3 0.841
MEKK1MEKK1 0.758 -0.168 1 0.769
NEK11NEK11 0.757 -0.026 1 0.750
MRCKBMRCKB 0.757 0.066 -3 0.802
CAMK1ACAMK1A 0.757 0.056 -3 0.731
CHK2CHK2 0.757 0.072 -3 0.722
GCKGCK 0.756 0.061 1 0.772
PKN1PKN1 0.756 0.003 -3 0.797
MOKMOK 0.756 0.066 1 0.751
PINK1PINK1 0.756 -0.107 1 0.832
PERKPERK 0.755 -0.184 -2 0.835
CK1DCK1D 0.755 0.000 -3 0.489
DMPK1DMPK1 0.755 0.119 -3 0.818
YANK3YANK3 0.755 -0.029 2 0.157
TLK1TLK1 0.753 -0.101 -2 0.838
GRK3GRK3 0.753 -0.010 -2 0.698
TTBK1TTBK1 0.753 -0.149 2 0.142
PBKPBK 0.752 0.066 1 0.840
PLK2PLK2 0.752 0.004 -3 0.711
CK1A2CK1A2 0.752 -0.012 -3 0.492
MEKK6MEKK6 0.752 -0.071 1 0.771
IRAK1IRAK1 0.752 -0.152 -1 0.761
STK33STK33 0.752 -0.078 2 0.175
HRIHRI 0.752 -0.188 -2 0.851
NEK8NEK8 0.752 -0.124 2 0.190
PDK1PDK1 0.751 -0.048 1 0.751
TAK1TAK1 0.751 0.041 1 0.797
HPK1HPK1 0.751 0.036 1 0.747
CAMKK1CAMKK1 0.750 -0.082 -2 0.759
CDK6CDK6 0.748 -0.006 1 0.653
TAO2TAO2 0.748 -0.114 2 0.196
CRIKCRIK 0.748 0.081 -3 0.790
MST2MST2 0.748 -0.038 1 0.774
BUB1BUB1 0.748 0.008 -5 0.804
MAP3K15MAP3K15 0.747 -0.096 1 0.729
CK1G1CK1G1 0.747 -0.066 -3 0.511
CAMKK2CAMKK2 0.747 -0.084 -2 0.752
CDK4CDK4 0.746 -0.009 1 0.624
PDHK3_TYRPDHK3_TYR 0.745 0.181 4 0.901
NEK4NEK4 0.744 -0.128 1 0.747
EEF2KEEF2K 0.743 -0.086 3 0.787
LRRK2LRRK2 0.743 -0.105 2 0.207
TNIKTNIK 0.743 -0.069 3 0.826
ROCK1ROCK1 0.742 0.051 -3 0.812
PDHK4_TYRPDHK4_TYR 0.742 0.243 2 0.297
KHS2KHS2 0.742 -0.014 1 0.749
MINKMINK 0.741 -0.094 1 0.750
NEK1NEK1 0.741 -0.102 1 0.762
KHS1KHS1 0.740 -0.046 1 0.731
LOKLOK 0.740 -0.090 -2 0.792
VRK1VRK1 0.740 -0.106 2 0.224
HGKHGK 0.739 -0.119 3 0.823
PKG1PKG1 0.739 0.002 -2 0.645
MST1MST1 0.739 -0.057 1 0.751
SLKSLK 0.739 -0.047 -2 0.731
MAP2K6_TYRMAP2K6_TYR 0.738 0.232 -1 0.876
RIPK2RIPK2 0.736 -0.135 1 0.698
TESK1_TYRTESK1_TYR 0.735 0.023 3 0.865
YSK1YSK1 0.735 -0.125 2 0.162
MEK2MEK2 0.733 -0.182 2 0.189
BIKEBIKE 0.733 0.066 1 0.805
BMPR2_TYRBMPR2_TYR 0.733 0.159 -1 0.881
MAP2K4_TYRMAP2K4_TYR 0.733 0.087 -1 0.860
EPHA6EPHA6 0.732 0.121 -1 0.844
PDHK1_TYRPDHK1_TYR 0.731 0.127 -1 0.878
HASPINHASPIN 0.730 -0.018 -1 0.734
EPHB4EPHB4 0.729 0.112 -1 0.820
PKMYT1_TYRPKMYT1_TYR 0.729 -0.040 3 0.842
MAP2K7_TYRMAP2K7_TYR 0.729 -0.021 2 0.247
EPHA4EPHA4 0.728 0.134 2 0.329
TTKTTK 0.728 -0.080 -2 0.822
LIMK2_TYRLIMK2_TYR 0.728 -0.030 -3 0.891
OSR1OSR1 0.727 -0.095 2 0.186
TXKTXK 0.726 0.163 1 0.861
ASK1ASK1 0.724 -0.119 1 0.715
PINK1_TYRPINK1_TYR 0.723 -0.092 1 0.822
NEK3NEK3 0.722 -0.184 1 0.719
CK1ACK1A 0.722 -0.030 -3 0.394
ALPHAK3ALPHAK3 0.721 -0.017 -1 0.753
MYO3BMYO3B 0.720 -0.111 2 0.169
AAK1AAK1 0.720 0.088 1 0.723
ITKITK 0.719 0.148 -1 0.768
DDR1DDR1 0.719 0.012 4 0.801
TNK2TNK2 0.719 0.026 3 0.752
EPHB3EPHB3 0.719 0.081 -1 0.803
SRMSSRMS 0.718 0.129 1 0.837
RETRET 0.718 -0.057 1 0.761
EPHB2EPHB2 0.718 0.091 -1 0.797
PTK2PTK2 0.717 0.161 -1 0.810
EPHB1EPHB1 0.717 0.082 1 0.823
LIMK1_TYRLIMK1_TYR 0.716 -0.163 2 0.193
TYRO3TYRO3 0.716 -0.081 3 0.784
INSRRINSRR 0.716 -0.005 3 0.745
YES1YES1 0.716 0.030 -1 0.798
JAK3JAK3 0.716 0.006 1 0.755
BLKBLK 0.716 0.117 -1 0.802
MYO3AMYO3A 0.714 -0.131 1 0.725
YANK2YANK2 0.714 -0.056 2 0.154
MST1RMST1R 0.714 -0.070 3 0.806
FGFR2FGFR2 0.714 -0.005 3 0.799
FGRFGR 0.714 0.000 1 0.857
TAO1TAO1 0.713 -0.145 1 0.682
EPHA3EPHA3 0.713 0.040 2 0.286
EPHA7EPHA7 0.713 0.065 2 0.292
CSF1RCSF1R 0.712 -0.033 3 0.792
EPHA5EPHA5 0.712 0.104 2 0.322
ABL2ABL2 0.712 -0.023 -1 0.748
LCKLCK 0.711 0.061 -1 0.796
FYNFYN 0.710 0.127 -1 0.784
ROS1ROS1 0.710 -0.167 3 0.759
MERTKMERTK 0.710 -0.017 3 0.782
BMXBMX 0.709 0.095 -1 0.674
KDRKDR 0.709 -0.019 3 0.770
HCKHCK 0.709 0.001 -1 0.789
AXLAXL 0.709 -0.054 3 0.785
DDR2DDR2 0.709 0.075 3 0.731
TEKTEK 0.708 -0.003 3 0.725
FERFER 0.708 -0.060 1 0.859
PTK2BPTK2B 0.708 0.056 -1 0.708
ABL1ABL1 0.707 -0.048 -1 0.734
KITKIT 0.707 0.014 3 0.792
TNK1TNK1 0.706 -0.107 3 0.770
FGFR3FGFR3 0.706 0.022 3 0.777
FLT1FLT1 0.706 0.057 -1 0.824
STLK3STLK3 0.706 -0.168 1 0.706
TYK2TYK2 0.706 -0.247 1 0.755
JAK2JAK2 0.705 -0.198 1 0.749
METMET 0.705 -0.002 3 0.783
FGFR1FGFR1 0.704 -0.092 3 0.765
NEK10_TYRNEK10_TYR 0.703 -0.108 1 0.659
PDGFRBPDGFRB 0.703 -0.176 3 0.795
EPHA8EPHA8 0.702 0.046 -1 0.800
EPHA1EPHA1 0.701 -0.039 3 0.761
TECTEC 0.701 0.003 -1 0.669
TNNI3K_TYRTNNI3K_TYR 0.699 -0.139 1 0.758
EPHA2EPHA2 0.699 0.080 -1 0.761
FLT4FLT4 0.698 -0.049 3 0.761
FLT3FLT3 0.698 -0.118 3 0.777
NTRK1NTRK1 0.697 -0.109 -1 0.786
LYNLYN 0.696 0.020 3 0.712
ERBB2ERBB2 0.696 -0.063 1 0.726
WEE1_TYRWEE1_TYR 0.695 -0.095 -1 0.729
BTKBTK 0.695 -0.076 -1 0.714
SRCSRC 0.695 0.035 -1 0.764
FRKFRK 0.694 -0.022 -1 0.786
LTKLTK 0.694 -0.139 3 0.733
SYKSYK 0.694 0.091 -1 0.778
JAK1JAK1 0.693 -0.162 1 0.694
INSRINSR 0.693 -0.117 3 0.721
PDGFRAPDGFRA 0.692 -0.227 3 0.789
ALKALK 0.690 -0.179 3 0.701
CSKCSK 0.689 -0.052 2 0.276
FGFR4FGFR4 0.689 -0.025 -1 0.733
EGFREGFR 0.689 -0.042 1 0.633
PTK6PTK6 0.688 -0.205 -1 0.682
NTRK2NTRK2 0.688 -0.171 3 0.762
MATKMATK 0.688 -0.055 -1 0.689
ERBB4ERBB4 0.688 0.032 1 0.658
CK1G3CK1G3 0.688 -0.061 -3 0.346
NTRK3NTRK3 0.688 -0.109 -1 0.738
IGF1RIGF1R 0.681 -0.096 3 0.664
CK1G2CK1G2 0.678 -0.021 -3 0.433
ZAP70ZAP70 0.675 0.039 -1 0.704
MUSKMUSK 0.671 -0.148 1 0.638
FESFES 0.666 -0.069 -1 0.648