Motif 1224 (n=42)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
O75179	ANKRD17	T5	ochoa	Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)	Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250\|UniProtKB:Q99NH0, ECO:0000269\|PubMed:17276651, ECO:0000269\|PubMed:19150984, ECO:0000269\|PubMed:22328336, ECO:0000269\|PubMed:23711367}.
O75312	ZPR1	S4	ochoa	Zinc finger protein ZPR1 (Zinc finger protein 259)	Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269\|PubMed:11283611, ECO:0000269\|PubMed:17068332, ECO:0000269\|PubMed:22422766, ECO:0000269\|PubMed:29851065}.
O75340	PDCD6	Y4	ochoa	Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)	Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250\|UniProtKB:P12815, ECO:0000269\|PubMed:16132846, ECO:0000269\|PubMed:19520058, ECO:0000269\|PubMed:19864416, ECO:0000269\|PubMed:20691033, ECO:0000269\|PubMed:21893193, ECO:0000269\|PubMed:25667979, ECO:0000269\|PubMed:27716508, ECO:0000269\|PubMed:27784779, ECO:0000269\|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250\|UniProtKB:P12815}.
P06400	RB1	T5	psp	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250\|UniProtKB:P13405, ECO:0000250\|UniProtKB:P33568, ECO:0000269\|PubMed:10499802, ECO:0000269\|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269\|PubMed:1316611, ECO:0000269\|PubMed:17974914, ECO:0000269\|PubMed:18701596, ECO:0000269\|PubMed:2839300, ECO:0000269\|PubMed:8892909}.
P10412	H1-4	T4	ochoa	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16157	ANK1	S4	ochoa	Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269\|PubMed:12456646, ECO:0000269\|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269\|PubMed:12527750}.
P16401	H1-5	T4	ochoa	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16402	H1-3	T4	ochoa	Histone H1.3 (Histone H1c) (Histone H1s-2)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T4	ochoa	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P20591	MX1	S4	ochoa	Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]	Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. {ECO:0000269\|PubMed:11880649, ECO:0000269\|PubMed:14687945, ECO:0000269\|PubMed:14752052, ECO:0000269\|PubMed:15047845, ECO:0000269\|PubMed:15355513, ECO:0000269\|PubMed:15757897, ECO:0000269\|PubMed:16202617, ECO:0000269\|PubMed:16413306, ECO:0000269\|PubMed:17374778, ECO:0000269\|PubMed:18668195, ECO:0000269\|PubMed:19109387, ECO:0000269\|PubMed:21900240, ECO:0000269\|PubMed:21992152}.
P35659	DEK	S4	ochoa	Protein DEK	Involved in chromatin organization. {ECO:0000269\|PubMed:17524367}.
P35713	SOX18	S4	ochoa	Transcription factor SOX-18	Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. {ECO:0000250\|UniProtKB:P43680}.
P43007	SLC1A4	S4	ochoa	Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4)	Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269\|PubMed:14502423, ECO:0000269\|PubMed:26041762, ECO:0000269\|PubMed:8101838, ECO:0000269\|PubMed:8340364}.
P49366	DHPS	S4	ochoa	Deoxyhypusine synthase (DHS) (EC 2.5.1.46)	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269\|PubMed:30661771}.
P58012	FOXL2	S4	psp	Forkhead box protein L2	Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269\|PubMed:16153597, ECO:0000269\|PubMed:19010791, ECO:0000269\|PubMed:19429596, ECO:0000269\|PubMed:19744555}.
P58012	FOXL2	Y5	psp	Forkhead box protein L2	Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269\|PubMed:16153597, ECO:0000269\|PubMed:19010791, ECO:0000269\|PubMed:19429596, ECO:0000269\|PubMed:19744555}.
P69905	HBA1;	S4	ochoa	Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin]	Involved in oxygen transport from the lung to the various peripheral tissues.; FUNCTION: [Hemopressin]: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling (PubMed:18077343). {ECO:0000269\|PubMed:18077343}.
Q02539	H1-1	T4	ochoa	Histone H1.1 (Histone H1a)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q06330	RBPJ	T4	ochoa	Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)	Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250\|UniProtKB:P31266, ECO:0000269\|PubMed:21991380, ECO:0000269\|PubMed:23303788}.
Q08AG7	MZT1	S3	ochoa	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809). {ECO:0000269\|PubMed:20360068, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
Q08AG7	MZT1	S4	ochoa	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809). {ECO:0000269\|PubMed:20360068, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
Q08AG7	MZT1	S5	ochoa	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809). {ECO:0000269\|PubMed:20360068, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
Q13263	TRIM28	S4	ochoa	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250\|UniProtKB:Q62318, ECO:0000269\|PubMed:10347202, ECO:0000269\|PubMed:11959841, ECO:0000269\|PubMed:15882967, ECO:0000269\|PubMed:16107876, ECO:0000269\|PubMed:16862143, ECO:0000269\|PubMed:17079232, ECO:0000269\|PubMed:17178852, ECO:0000269\|PubMed:17704056, ECO:0000269\|PubMed:17942393, ECO:0000269\|PubMed:18060868, ECO:0000269\|PubMed:18082607, ECO:0000269\|PubMed:20424263, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:20864041, ECO:0000269\|PubMed:21940674, ECO:0000269\|PubMed:23543754, ECO:0000269\|PubMed:23665872, ECO:0000269\|PubMed:24623306, ECO:0000269\|PubMed:27029610, ECO:0000269\|PubMed:8769649, ECO:0000269\|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269\|PubMed:24741090}.
Q13614	MTMR2	S4	ochoa	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase)	Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11733541, PubMed:12668758, PubMed:14690594, PubMed:21372139). Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation (PubMed:35580604). {ECO:0000269\|PubMed:11733541, ECO:0000269\|PubMed:12668758, ECO:0000269\|PubMed:14690594, ECO:0000269\|PubMed:21372139, ECO:0000269\|PubMed:35580604}.
Q14151	SAFB2	T4	ochoa	Scaffold attachment factor B2 (SAF-B2)	Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q15172	PPP2R5A	S4	ochoa	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q5T4S7	UBR4	T3	ochoa	E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600)	E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269\|PubMed:16214886, ECO:0000269\|PubMed:23932781, ECO:0000269\|PubMed:25582440, ECO:0000269\|PubMed:29033132, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:37891180, ECO:0000269\|PubMed:38030679, ECO:0000269\|PubMed:38182926, ECO:0000269\|PubMed:38297121}.
Q5T4S7	UBR4	S4	ochoa	E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600)	E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269\|PubMed:16214886, ECO:0000269\|PubMed:23932781, ECO:0000269\|PubMed:25582440, ECO:0000269\|PubMed:29033132, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:37891180, ECO:0000269\|PubMed:38030679, ECO:0000269\|PubMed:38182926, ECO:0000269\|PubMed:38297121}.
Q5VV17	OTUD1	Y4	ochoa	OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)	Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:36445135}.
Q7KZF4	SND1	S4	ochoa	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250\|UniProtKB:Q78PY7, ECO:0000269\|PubMed:12234934, ECO:0000269\|PubMed:18453631, ECO:0000269\|PubMed:28546213, ECO:0000269\|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269\|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269\|PubMed:37794589}.
Q86TI2	DPP9	T4	ochoa	Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)	Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269\|PubMed:12662155, ECO:0000269\|PubMed:16475979, ECO:0000269\|PubMed:19667070, ECO:0000269\|PubMed:27820798, ECO:0000269\|PubMed:29382749, ECO:0000269\|PubMed:29967349, ECO:0000269\|PubMed:30291141, ECO:0000269\|PubMed:31525884, ECO:0000269\|PubMed:32796818, ECO:0000269\|PubMed:33731929, ECO:0000269\|PubMed:33731932, ECO:0000269\|PubMed:34019797, ECO:0000269\|PubMed:36112693, ECO:0000269\|PubMed:36357533}.
Q86VQ6	TXNRD3	S4	ochoa	Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene) (Thioredoxin reductase TR2)	Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250\|UniProtKB:Q99MD6}.
Q8N697	SLC15A4	S4	ochoa	Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)	Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250\|UniProtKB:O09014, ECO:0000250\|UniProtKB:Q91W98, ECO:0000269\|PubMed:16289537, ECO:0000269\|PubMed:25238095, ECO:0000269\|PubMed:29224352, ECO:0000269\|PubMed:31073693, ECO:0000269\|PubMed:32433612}.
Q8ND24	RNF214	S4	ochoa	RING finger protein 214	None
Q92945	KHSRP	Y4	ochoa	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75)	Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269\|PubMed:11003644, ECO:0000269\|PubMed:8940189, ECO:0000269\|PubMed:9136930}.
Q96B49	TOMM6	S4	ochoa	Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog)	None
Q96C90	PPP1R14B	S4	ochoa	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein)	Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}.
Q96NT5	SLC46A1	S4	ochoa	Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)	Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:19762432, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:31792273, PubMed:32893190, PubMed:34619546). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:32893190). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:32893190, PubMed:34040256). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases (PubMed:18524888, PubMed:19762432, PubMed:22345511, PubMed:25608532, PubMed:28802835, PubMed:29326243, PubMed:34040256, PubMed:34619546). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (PubMed:19074442). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:17156779). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:32621820). Hence, participates in the trafficking of heme and increases intracellular iron content (PubMed:32621820). {ECO:0000269\|PubMed:17129779, ECO:0000269\|PubMed:17156779, ECO:0000269\|PubMed:17446347, ECO:0000269\|PubMed:17475902, ECO:0000269\|PubMed:18524888, ECO:0000269\|PubMed:19074442, ECO:0000269\|PubMed:19389703, ECO:0000269\|PubMed:19762432, ECO:0000269\|PubMed:22345511, ECO:0000269\|PubMed:25504888, ECO:0000269\|PubMed:25608532, ECO:0000269\|PubMed:28802835, ECO:0000269\|PubMed:29326243, ECO:0000269\|PubMed:29344585, ECO:0000269\|PubMed:30858177, ECO:0000269\|PubMed:31494288, ECO:0000269\|PubMed:31792273, ECO:0000269\|PubMed:32621820, ECO:0000269\|PubMed:32893190, ECO:0000269\|PubMed:34040256, ECO:0000269\|PubMed:34619546}.; FUNCTION: [Isoform 2]: Inactive isoform which is not able to mediate proton-coupled folate transport. {ECO:0000269\|PubMed:17129779}.
Q9H6S3	EPS8L2	S4	ochoa	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250\|UniProtKB:Q99K30, ECO:0000269\|PubMed:14565974}.
Q9NUP7	TRMT13	S4	ochoa	tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76)	tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250\|UniProtKB:Q12383}.
Q9UBT7	CTNNAL1	S4	ochoa	Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1)	May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Q9UMX0	UBQLN1	S4	ochoa	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250\|UniProtKB:Q9JJP9, ECO:0000269\|PubMed:18307982, ECO:0000269\|PubMed:19148225, ECO:0000269\|PubMed:19822669, ECO:0000269\|PubMed:20529957, ECO:0000269\|PubMed:21695056, ECO:0000269\|PubMed:22233804, ECO:0000269\|PubMed:23307288, ECO:0000269\|PubMed:23459205, ECO:0000303\|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269\|PubMed:18953672, ECO:0000269\|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269\|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269\|PubMed:18953672, ECO:0000269\|PubMed:21143716}.

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reactome_id	name	p	-log10_p
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	7.029377e-12	11.153
R-HSA-140342	Apoptosis induced DNA fragmentation	2.845330e-10	9.546
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	6.926076e-10	9.160
R-HSA-75153	Apoptotic execution phase	3.253065e-07	6.488
R-HSA-2559583	Cellular Senescence	8.126065e-07	6.090
R-HSA-109581	Apoptosis	1.051845e-04	3.978
R-HSA-427975	Proton/oligopeptide cotransporters	2.097103e-04	3.678
R-HSA-9959399	SLC-mediated transport of oligopeptides	3.265904e-04	3.486
R-HSA-2262752	Cellular responses to stress	2.706334e-04	3.568
R-HSA-5357801	Programmed Cell Death	2.945214e-04	3.531
R-HSA-8953897	Cellular responses to stimuli	6.748275e-04	3.171
R-HSA-9661070	Defective translocation of RB1 mutants to the nucleus	2.604892e-03	2.584
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ...	1.553032e-02	1.809
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	3.587162e-02	1.445
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	3.587162e-02	1.445
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	3.587162e-02	1.445
R-HSA-5339716	Signaling by GSK3beta mutants	3.838525e-02	1.416
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	4.089249e-02	1.388
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	4.089249e-02	1.388
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	4.089249e-02	1.388
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	4.089249e-02	1.388
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	4.089249e-02	1.388
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	4.089249e-02	1.388
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	4.339334e-02	1.363
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	4.339334e-02	1.363
R-HSA-196299	Beta-catenin phosphorylation cascade	4.837596e-02	1.315
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	5.085777e-02	1.294
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	5.085777e-02	1.294
R-HSA-350054	Notch-HLH transcription pathway	7.048602e-02	1.152
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	1.117367e-02	1.952
R-HSA-445095	Interaction between L1 and Ankyrins	8.255187e-02	1.083
R-HSA-171306	Packaging Of Telomere Ends	8.255187e-02	1.083
R-HSA-5334118	DNA methylation	8.733527e-02	1.059
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	8.971784e-02	1.047
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	1.776801e-02	1.750
R-HSA-212300	PRC2 methylates histones and DNA	1.062266e-01	0.974
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	8.971784e-02	1.047
R-HSA-2299718	Condensation of Prophase Chromosomes	8.857494e-03	2.053
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	5.175177e-02	1.286
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	5.175177e-02	1.286
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	6.561644e-02	1.183
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	5.175177e-02	1.286
R-HSA-389513	Co-inhibition by CTLA4	6.317231e-02	1.199
R-HSA-3214815	HDACs deacetylate histones	1.518006e-01	0.819
R-HSA-9842860	Regulation of endogenous retroelements	3.522355e-02	1.453
R-HSA-9670095	Inhibition of DNA recombination at telomere	1.155286e-01	0.937
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	1.606392e-01	0.794
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	1.178393e-01	0.929
R-HSA-8941856	RUNX3 regulates NOTCH signaling	4.089249e-02	1.388
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	1.819675e-02	1.740
R-HSA-9860276	SLC15A4:TASL-dependent IRF5 activation	2.065457e-02	1.685
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	3.082510e-02	1.511
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	3.838525e-02	1.416
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	1.383720e-01	0.859
R-HSA-1221632	Meiotic synapsis	1.473472e-01	0.832
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	1.015399e-01	0.993
R-HSA-1483248	Synthesis of PIPs at the ER membrane	3.587162e-02	1.445
R-HSA-9675126	Diseases of mitotic cell cycle	9.446477e-02	1.025
R-HSA-427359	SIRT1 negatively regulates rRNA expression	1.085610e-01	0.964
R-HSA-212165	Epigenetic regulation of gene expression	1.210173e-02	1.917
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	1.628347e-01	0.788
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.628347e-01	0.788
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.628347e-01	0.788
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	1.628347e-01	0.788
R-HSA-9012852	Signaling by NOTCH3	1.518006e-01	0.819
R-HSA-4839744	Signaling by APC mutants	3.587162e-02	1.445
R-HSA-4839735	Signaling by AXIN mutants	3.838525e-02	1.416
R-HSA-4839748	Signaling by AMER1 mutants	3.838525e-02	1.416
R-HSA-113510	E2F mediated regulation of DNA replication	6.072195e-02	1.217
R-HSA-73728	RNA Polymerase I Promoter Opening	8.255187e-02	1.083
R-HSA-4791275	Signaling by WNT in cancer	9.446477e-02	1.025
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	1.155286e-01	0.937
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	1.178393e-01	0.929
R-HSA-774815	Nucleosome assembly	1.293046e-01	0.888
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	1.293046e-01	0.888
R-HSA-73772	RNA Polymerase I Promoter Escape	1.451120e-01	0.838
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	1.473472e-01	0.832
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	1.628347e-01	0.788
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	7.418540e-02	1.130
R-HSA-447043	Neurofascin interactions	2.320693e-02	1.634
R-HSA-1980145	Signaling by NOTCH2	1.015399e-01	0.993
R-HSA-9927020	Heme assimilation	5.333325e-02	1.273
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	8.255187e-02	1.083
R-HSA-912446	Meiotic recombination	1.428711e-01	0.845
R-HSA-5357786	TNFR1-induced proapoptotic signaling	6.561644e-02	1.183
R-HSA-9710421	Defective pyroptosis	1.247360e-01	0.904
R-HSA-157118	Signaling by NOTCH	1.473245e-01	0.832
R-HSA-68877	Mitotic Prometaphase	1.057084e-01	0.976
R-HSA-9824272	Somitogenesis	1.293046e-01	0.888
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	7.774399e-02	1.109
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	1.361139e-01	0.866
R-HSA-2644603	Signaling by NOTCH1 in Cancer	1.628347e-01	0.788
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	5.580243e-02	1.253
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	8.255187e-02	1.083
R-HSA-68875	Mitotic Prophase	4.787344e-02	1.320
R-HSA-447038	NrCAM interactions	1.809571e-02	1.742
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	5.085777e-02	1.294
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	6.072195e-02	1.217
R-HSA-110331	Cleavage of the damaged purine	1.085610e-01	0.964
R-HSA-1480926	O2/CO2 exchange in erythrocytes	6.072195e-02	1.217
R-HSA-73927	Depurination	1.108895e-01	0.955
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	8.494662e-02	1.071
R-HSA-447041	CHL1 interactions	2.575279e-02	1.589
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected ...	9.446477e-02	1.025
R-HSA-68886	M Phase	2.062366e-02	1.686
R-HSA-68616	Assembly of the ORC complex at the origin of replication	9.682916e-02	1.014
R-HSA-69231	Cyclin D associated events in G1	1.270233e-01	0.896
R-HSA-69236	G1 Phase	1.270233e-01	0.896
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	4.089249e-02	1.388
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	7.533084e-02	1.123
R-HSA-5673000	RAF activation	1.015399e-01	0.993
R-HSA-9609690	HCMV Early Events	1.082023e-01	0.966
R-HSA-1912408	Pre-NOTCH Transcription and Translation	2.817476e-02	1.550
R-HSA-8941326	RUNX2 regulates bone development	1.062266e-01	0.974
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	3.335157e-02	1.477
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum stress	8.494662e-02	1.071
R-HSA-388841	Regulation of T cell activation by CD28 family	1.618746e-01	0.791
R-HSA-1912422	Pre-NOTCH Expression and Processing	4.227050e-02	1.374
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	1.451120e-01	0.838
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	1.540187e-01	0.812
R-HSA-9707616	Heme signaling	1.449871e-02	1.839
R-HSA-352230	Amino acid transport across the plasma membrane	1.606392e-01	0.794
R-HSA-432142	Platelet sensitization by LDL	5.826532e-02	1.235
R-HSA-9616222	Transcriptional regulation of granulopoiesis	1.449871e-02	1.839
R-HSA-1640170	Cell Cycle	1.211038e-01	0.917
R-HSA-389356	Co-stimulation by CD28	1.361139e-01	0.866
R-HSA-73929	Base-Excision Repair, AP Site Formation	1.495767e-01	0.825
R-HSA-381042	PERK regulates gene expression	1.038862e-01	0.983
R-HSA-9764560	Regulation of CDH1 Gene Transcription	1.776801e-02	1.750
R-HSA-69278	Cell Cycle, Mitotic	6.604157e-02	1.180
R-HSA-909733	Interferon alpha/beta signaling	4.472817e-02	1.349
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	1.584380e-01	0.800
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	1.628347e-01	0.788
R-HSA-75893	TNF signaling	1.540187e-01	0.812
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	1.270233e-01	0.896
R-HSA-196757	Metabolism of folate and pterines	1.085610e-01	0.964
R-HSA-9609646	HCMV Infection	1.563856e-01	0.806
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	8.494662e-02	1.071
R-HSA-5675221	Negative regulation of MAPK pathway	1.201441e-01	0.920
R-HSA-9690406	Transcriptional regulation of testis differentiation	5.333325e-02	1.273
R-HSA-9764265	Regulation of CDH1 Expression and Function	8.952124e-02	1.048
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	8.952124e-02	1.048
R-HSA-2559585	Oncogene Induced Senescence	1.038862e-01	0.983
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	5.043842e-02	1.297
R-HSA-110329	Cleavage of the damaged pyrimidine	1.224430e-01	0.912
R-HSA-73928	Depyrimidination	1.224430e-01	0.912
R-HSA-9682706	Replication of the SARS-CoV-1 genome	4.339334e-02	1.363
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	1.015399e-01	0.993
R-HSA-9694686	Replication of the SARS-CoV-2 genome	5.580243e-02	1.253
R-HSA-5205647	Mitophagy	1.015399e-01	0.993
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	7.418540e-02	1.130
R-HSA-201681	TCF dependent signaling in response to WNT	9.751624e-02	1.011
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	1.082023e-01	0.966
R-HSA-913531	Interferon Signaling	8.808938e-02	1.055
R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	4.588783e-02	1.338
R-HSA-186712	Regulation of beta-cell development	1.606392e-01	0.794
R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	6.072195e-02	1.217
R-HSA-418990	Adherens junctions interactions	1.278260e-01	0.893
R-HSA-421270	Cell-cell junction organization	1.572978e-01	0.803
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	1.361139e-01	0.866
R-HSA-425407	SLC-mediated transmembrane transport	9.520513e-02	1.021
R-HSA-5357905	Regulation of TNFR1 signaling	1.315802e-01	0.881
R-HSA-382551	Transport of small molecules	1.180193e-01	0.928
R-HSA-9772572	Early SARS-CoV-2 Infection Events	1.584380e-01	0.800
R-HSA-69620	Cell Cycle Checkpoints	1.637124e-01	0.786
R-HSA-9793380	Formation of paraxial mesoderm	1.650247e-01	0.782
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	1.672091e-01	0.777
R-HSA-1268020	Mitochondrial protein import	1.672091e-01	0.777
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	1.737288e-01	0.760
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	1.758909e-01	0.755
R-HSA-6782315	tRNA modification in the nucleus and cytosol	1.758909e-01	0.755
R-HSA-5693606	DNA Double Strand Break Response	1.780475e-01	0.749
R-HSA-9958863	SLC-mediated transport of amino acids	1.780475e-01	0.749
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	1.801986e-01	0.744
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	1.801986e-01	0.744
R-HSA-446728	Cell junction organization	1.822929e-01	0.739
R-HSA-195253	Degradation of beta-catenin by the destruction complex	1.844843e-01	0.734
R-HSA-69202	Cyclin E associated events during G1/S transition	1.844843e-01	0.734
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	1.860487e-01	0.730
R-HSA-427413	NoRC negatively regulates rRNA expression	1.866190e-01	0.729
R-HSA-9638482	Metal ion assimilation from the host	1.866190e-01	0.729
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	1.866190e-01	0.729
R-HSA-453276	Regulation of mitotic cell cycle	1.866190e-01	0.729
R-HSA-5578749	Transcriptional regulation by small RNAs	1.887482e-01	0.724
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	1.887482e-01	0.724
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	1.887482e-01	0.724
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	1.908720e-01	0.719
R-HSA-9013694	Signaling by NOTCH4	1.929903e-01	0.714
R-HSA-69473	G2/M DNA damage checkpoint	1.929903e-01	0.714
R-HSA-380287	Centrosome maturation	1.951032e-01	0.710
R-HSA-1169408	ISG15 antiviral mechanism	1.951032e-01	0.710
R-HSA-8852135	Protein ubiquitination	1.951032e-01	0.710
R-HSA-917937	Iron uptake and transport	1.951032e-01	0.710
R-HSA-1980143	Signaling by NOTCH1	1.972107e-01	0.705
R-HSA-73854	RNA Polymerase I Promoter Clearance	1.972107e-01	0.705
R-HSA-195721	Signaling by WNT	2.011832e-01	0.696
R-HSA-73864	RNA Polymerase I Transcription	2.014096e-01	0.696
R-HSA-9659379	Sensory processing of sound	2.035010e-01	0.691
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	2.055871e-01	0.687
R-HSA-9833482	PKR-mediated signaling	2.055871e-01	0.687
R-HSA-5693607	Processing of DNA double-strand break ends	2.076678e-01	0.683
R-HSA-977225	Amyloid fiber formation	2.076678e-01	0.683
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	2.097432e-01	0.678
R-HSA-9707564	Cytoprotection by HMOX1	2.118133e-01	0.674
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.138781e-01	0.670
R-HSA-1500620	Meiosis	2.159376e-01	0.666
R-HSA-6802957	Oncogenic MAPK signaling	2.159376e-01	0.666
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	2.179918e-01	0.662
R-HSA-141424	Amplification of signal from the kinetochores	2.179918e-01	0.662
R-HSA-1500931	Cell-Cell communication	2.183856e-01	0.661
R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	2.200408e-01	0.657
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	2.241231e-01	0.650
R-HSA-9645723	Diseases of programmed cell death	2.241231e-01	0.650
R-HSA-9663891	Selective autophagy	2.241231e-01	0.650
R-HSA-73884	Base Excision Repair	2.281845e-01	0.642
R-HSA-68867	Assembly of the pre-replicative complex	2.362452e-01	0.627
R-HSA-2168880	Scavenging of heme from plasma	2.422367e-01	0.616
R-HSA-6807878	COPI-mediated anterograde transport	2.442236e-01	0.612
R-HSA-157579	Telomere Maintenance	2.462055e-01	0.609
R-HSA-8878159	Transcriptional regulation by RUNX3	2.462055e-01	0.609
R-HSA-3214847	HATs acetylate histones	2.501540e-01	0.602
R-HSA-69618	Mitotic Spindle Checkpoint	2.521207e-01	0.598
R-HSA-1483255	PI Metabolism	2.560390e-01	0.592
R-HSA-2559580	Oxidative Stress Induced Senescence	2.560390e-01	0.592
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	2.599372e-01	0.585
R-HSA-5619507	Activation of HOX genes during differentiation	2.618789e-01	0.582
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	2.618789e-01	0.582
R-HSA-418346	Platelet homeostasis	2.657472e-01	0.576
R-HSA-211000	Gene Silencing by RNA	2.676740e-01	0.572
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	2.676740e-01	0.572
R-HSA-9700206	Signaling by ALK in cancer	2.676740e-01	0.572
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	2.715127e-01	0.566
R-HSA-69002	DNA Replication Pre-Initiation	2.715127e-01	0.566
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	2.791312e-01	0.554
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	2.810237e-01	0.551
R-HSA-983169	Class I MHC mediated antigen processing & presentation	2.842267e-01	0.546
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	2.847941e-01	0.545
R-HSA-373760	L1CAM interactions	2.885451e-01	0.540
R-HSA-5693538	Homology Directed Repair	2.922770e-01	0.534
R-HSA-8878166	Transcriptional regulation by RUNX2	2.941358e-01	0.531
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	2.978390e-01	0.526
R-HSA-73886	Chromosome Maintenance	2.978390e-01	0.526
R-HSA-9816359	Maternal to zygotic transition (MZT)	3.015233e-01	0.521
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	3.015233e-01	0.521
R-HSA-1280218	Adaptive Immune System	3.024976e-01	0.519
R-HSA-69206	G1/S Transition	3.070143e-01	0.513
R-HSA-69481	G2/M Checkpoints	3.106516e-01	0.508
R-HSA-199418	Negative regulation of the PI3K/AKT network	3.160725e-01	0.500
R-HSA-1474165	Reproduction	3.178703e-01	0.498
R-HSA-9018519	Estrogen-dependent gene expression	3.303258e-01	0.481
R-HSA-381119	Unfolded Protein Response (UPR)	3.355957e-01	0.474
R-HSA-1632852	Macroautophagy	3.390864e-01	0.470
R-HSA-8856828	Clathrin-mediated endocytosis	3.442890e-01	0.463
R-HSA-453279	Mitotic G1 phase and G1/S transition	3.494515e-01	0.457
R-HSA-199977	ER to Golgi Anterograde Transport	3.511635e-01	0.454
R-HSA-69242	S Phase	3.528712e-01	0.452
R-HSA-9758941	Gastrulation	3.545744e-01	0.450
R-HSA-6798695	Neutrophil degranulation	3.555101e-01	0.449
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	3.562733e-01	0.448
R-HSA-5693532	DNA Double-Strand Break Repair	3.613437e-01	0.442
R-HSA-69306	DNA Replication	3.613437e-01	0.442
R-HSA-9609507	Protein localization	3.613437e-01	0.442
R-HSA-73887	Death Receptor Signaling	3.630252e-01	0.440
R-HSA-9612973	Autophagy	3.663751e-01	0.436
R-HSA-5653656	Vesicle-mediated transport	3.682456e-01	0.434
R-HSA-2467813	Separation of Sister Chromatids	3.796039e-01	0.421
R-HSA-72306	tRNA processing	3.909576e-01	0.408
R-HSA-212436	Generic Transcription Pathway	3.921106e-01	0.407
R-HSA-9909648	Regulation of PD-L1(CD274) expression	3.941640e-01	0.404
R-HSA-5689880	Ub-specific processing proteases	3.957611e-01	0.403
R-HSA-9678108	SARS-CoV-1 Infection	3.989429e-01	0.399
R-HSA-69275	G2/M Transition	4.161525e-01	0.381
R-HSA-453274	Mitotic G2-G2/M phases	4.192295e-01	0.378
R-HSA-168898	Toll-like Receptor Cascades	4.238152e-01	0.373
R-HSA-389948	Co-inhibition by PD-1	4.373613e-01	0.359
R-HSA-948021	Transport to the Golgi and subsequent modification	4.403291e-01	0.356
R-HSA-9640148	Infection with Enterobacteria	4.418072e-01	0.355
R-HSA-597592	Post-translational protein modification	4.492912e-01	0.347
R-HSA-68882	Mitotic Anaphase	4.621054e-01	0.335
R-HSA-2555396	Mitotic Metaphase and Anaphase	4.635273e-01	0.334
R-HSA-73857	RNA Polymerase II Transcription	4.678038e-01	0.330
R-HSA-8878171	Transcriptional regulation by RUNX1	4.761610e-01	0.322
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	4.816823e-01	0.317
R-HSA-3247509	Chromatin modifying enzymes	4.871468e-01	0.312
R-HSA-8939211	ESR-mediated signaling	4.912082e-01	0.309
R-HSA-4839726	Chromatin organization	5.071422e-01	0.295
R-HSA-5688426	Deubiquitination	5.149255e-01	0.288
R-HSA-199991	Membrane Trafficking	5.253848e-01	0.280
R-HSA-9711123	Cellular response to chemical stress	5.313799e-01	0.275
R-HSA-1280215	Cytokine Signaling in Immune system	5.508659e-01	0.259
R-HSA-5673001	RAF/MAP kinase cascade	5.568158e-01	0.254
R-HSA-1483257	Phospholipid metabolism	5.638322e-01	0.249
R-HSA-1257604	PIP3 activates AKT signaling	5.638322e-01	0.249
R-HSA-5684996	MAPK1/MAPK3 signaling	5.649910e-01	0.248
R-HSA-9824446	Viral Infection Pathways	5.837854e-01	0.234
R-HSA-1266738	Developmental Biology	5.952105e-01	0.225
R-HSA-74160	Gene expression (Transcription)	6.055685e-01	0.218
R-HSA-168256	Immune System	6.094666e-01	0.215
R-HSA-9006925	Intracellular signaling by second messengers	6.151672e-01	0.211
R-HSA-5683057	MAPK family signaling cascades	6.202679e-01	0.207
R-HSA-9694516	SARS-CoV-2 Infection	6.222897e-01	0.206
R-HSA-73894	DNA Repair	6.332230e-01	0.198
R-HSA-1643685	Disease	6.338671e-01	0.198
R-HSA-9006931	Signaling by Nuclear Receptors	6.361508e-01	0.196
R-HSA-196854	Metabolism of vitamins and cofactors	6.371216e-01	0.196
R-HSA-8953854	Metabolism of RNA	6.613613e-01	0.180
R-HSA-9824439	Bacterial Infection Pathways	6.623994e-01	0.179
R-HSA-5663205	Infectious disease	6.659020e-01	0.177
R-HSA-446203	Asparagine N-linked glycosylation	6.901379e-01	0.161
R-HSA-422475	Axon guidance	7.774971e-01	0.109
R-HSA-392499	Metabolism of proteins	7.801880e-01	0.108
R-HSA-9679506	SARS-CoV Infections	7.834332e-01	0.106
R-HSA-9675108	Nervous system development	7.986990e-01	0.098
R-HSA-168249	Innate Immune System	8.775301e-01	0.057
R-HSA-109582	Hemostasis	8.839700e-01	0.054
R-HSA-9709957	Sensory Perception	9.671691e-01	0.014
R-HSA-162582	Signal Transduction	9.697375e-01	0.013
R-HSA-556833	Metabolism of lipids	9.839588e-01	0.007
R-HSA-1430728	Metabolism	9.998077e-01	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
BMPR1B	0.573	0.089	1	0.632
TGFBR1	0.568	0.109	-2	0.598
JNK2	0.565	0.103	1	0.601
CLK3	0.565	0.033	1	0.679
KIS	0.564	0.104	1	0.629
ERK5	0.563	0.116	1	0.777
MOS	0.563	0.043	1	0.608
CDK8	0.561	0.108	1	0.624
CDK19	0.561	0.110	1	0.615
HIPK4	0.560	0.090	1	0.597
BMPR1A	0.560	0.069	1	0.601
P38B	0.559	0.091	1	0.672
JNK3	0.559	0.093	1	0.615
ALK2	0.558	0.075	-2	0.591
P38D	0.557	0.101	1	0.568
P38A	0.557	0.098	1	0.688
CDC7	0.557	0.042	1	0.588
ALK4	0.557	0.078	-2	0.585
DSTYK	0.556	0.043	2	0.617
CLK2	0.556	0.037	-3	0.129
ACVR2B	0.555	0.040	-2	0.554
PRKD1	0.554	0.065	-3	0.200
NLK	0.554	0.086	1	0.652
P38G	0.553	0.073	1	0.581
DYRK2	0.552	0.064	1	0.630
PRPK	0.550	-0.011	-1	0.639
CDKL5	0.550	0.023	-3	0.170
ULK1	0.550	0.262	-3	0.453
MTOR	0.550	0.024	1	0.561
ERK1	0.549	0.078	1	0.651
BMPR2	0.549	-0.046	-2	0.537
SRPK1	0.549	0.011	-3	0.135
GRK1	0.548	-0.006	-2	0.505
COT	0.548	-0.078	2	0.581
ACVR2A	0.548	0.027	-2	0.541
ICK	0.548	0.011	-3	0.197
CDK1	0.547	0.048	1	0.622
GRK7	0.547	-0.024	1	0.564
MAPKAPK2	0.547	0.004	-3	0.134
HIPK2	0.546	0.062	1	0.580
CLK1	0.546	0.025	-3	0.141
CLK4	0.546	0.009	-3	0.144
PIM3	0.546	-0.028	-3	0.160
CHAK2	0.546	0.022	-1	0.657
JNK1	0.545	0.066	1	0.600
ATR	0.545	-0.018	1	0.510
HIPK1	0.545	0.047	1	0.636
CDKL1	0.544	-0.033	-3	0.171
DYRK4	0.544	0.064	1	0.604
ULK2	0.544	0.168	2	0.502
MAPKAPK3	0.543	0.001	-3	0.165
CDK7	0.543	0.059	1	0.629
PDHK4	0.542	-0.065	1	0.554
NEK9	0.542	0.135	2	0.559
MAK	0.542	0.038	-2	0.414
SRPK3	0.542	-0.007	-3	0.138
CAMK2D	0.542	0.001	-3	0.199
CDK18	0.542	0.057	1	0.609
LATS1	0.542	-0.051	-3	0.173
MPSK1	0.542	0.077	1	0.592
CK1D	0.541	-0.028	-3	0.073
HIPK3	0.541	0.068	1	0.615
NEK6	0.541	0.003	-2	0.519
CAMK1B	0.541	-0.064	-3	0.185
PRP4	0.540	-0.006	-3	0.155
SRPK2	0.540	-0.006	-3	0.120
CAMK2G	0.539	-0.044	2	0.534
GRK5	0.539	-0.091	-3	0.183
CDK13	0.539	0.058	1	0.610
CDK5	0.539	0.047	1	0.647
PRKD2	0.539	0.002	-3	0.162
IKKA	0.539	-0.040	-2	0.431
NEK7	0.538	-0.008	-3	0.267
TGFBR2	0.538	-0.006	-2	0.543
GRK6	0.538	-0.058	1	0.582
GAK	0.538	0.069	1	0.678
PDHK1	0.537	-0.025	1	0.531
RAF1	0.537	-0.085	1	0.534
PIM1	0.537	-0.038	-3	0.137
CK1E	0.537	-0.027	-3	0.087
CDK17	0.537	0.054	1	0.579
DAPK2	0.537	-0.057	-3	0.198
CDK3	0.536	0.050	1	0.599
PINK1	0.536	0.020	1	0.596
IKKB	0.536	-0.071	-2	0.412
SKMLCK	0.536	-0.061	-2	0.492
CAMLCK	0.536	-0.061	-2	0.454
NUAK2	0.535	-0.008	-3	0.195
LKB1	0.535	0.062	-3	0.265
CHK1	0.535	-0.015	-3	0.201
CAMK2A	0.535	-0.033	2	0.549
CAMK2B	0.534	-0.021	2	0.544
NIK	0.534	-0.107	-3	0.195
CDK9	0.534	0.054	1	0.617
HUNK	0.534	-0.003	2	0.578
NDR2	0.534	-0.057	-3	0.163
MOK	0.534	0.035	1	0.673
DYRK1B	0.534	0.032	1	0.614
CK1A2	0.534	-0.040	-3	0.069
CAMKK2	0.534	0.069	-2	0.394
GRK4	0.533	-0.065	-2	0.531
PKN3	0.533	-0.018	-3	0.249
FAM20C	0.533	0.033	2	0.495
PBK	0.533	0.079	1	0.662
GRK2	0.533	-0.035	-2	0.468
TLK2	0.533	-0.031	1	0.458
CDK12	0.533	0.050	1	0.591
LATS2	0.533	-0.054	-5	0.500
MASTL	0.532	-0.083	-2	0.447
MEK1	0.532	-0.063	2	0.581
PASK	0.532	-0.042	-3	0.181
DLK	0.532	-0.131	1	0.544
GCN2	0.531	-0.046	2	0.535
DYRK1A	0.531	0.019	1	0.612
RSK2	0.531	-0.056	-3	0.137
SBK	0.531	-0.021	-3	0.091
GRK3	0.530	-0.029	-2	0.460
CK2A2	0.530	0.006	1	0.527
TLK1	0.530	-0.026	-2	0.590
VRK2	0.530	-0.091	1	0.593
ERK2	0.529	0.035	1	0.631
NEK2	0.529	0.035	2	0.544
ATM	0.529	-0.027	1	0.443
CAMKK1	0.529	0.055	-2	0.397
SMG1	0.529	-0.011	1	0.455
PKR	0.529	-0.059	1	0.523
PLK1	0.529	-0.029	-2	0.457
BIKE	0.528	0.113	1	0.658
MLK2	0.528	-0.077	2	0.552
NEK5	0.528	0.037	1	0.526
PERK	0.528	-0.018	-2	0.531
CDK10	0.528	0.033	1	0.612
PRKD3	0.528	-0.033	-3	0.155
BRAF	0.527	-0.049	-4	0.095
MAPKAPK5	0.527	-0.014	-3	0.186
TBK1	0.527	-0.084	1	0.443
DYRK3	0.527	0.005	1	0.615
PIM2	0.527	-0.037	-3	0.141
AAK1	0.527	0.122	1	0.628
YSK4	0.527	-0.074	1	0.475
MST4	0.527	-0.059	2	0.609
ANKRD3	0.527	-0.107	1	0.540
RSK3	0.526	-0.057	-3	0.163
WNK1	0.526	-0.066	-2	0.487
IKKE	0.526	-0.078	1	0.434
P70S6KB	0.526	-0.081	-3	0.152
P90RSK	0.525	-0.061	-3	0.165
CDK14	0.525	0.032	1	0.622
AURC	0.525	-0.031	-2	0.300
CDK16	0.525	0.032	1	0.589
GSK3A	0.524	-0.005	4	0.399
DNAPK	0.524	-0.014	1	0.368
CDK2	0.524	0.000	1	0.653
MLK1	0.523	-0.124	2	0.523
NDR1	0.523	-0.102	-3	0.163
ERK7	0.523	0.015	2	0.326
BCKDK	0.522	-0.061	-1	0.558
AKT2	0.522	-0.050	-3	0.120
GSK3B	0.522	-0.004	4	0.393
MARK4	0.522	-0.048	4	0.545
HRI	0.521	-0.029	-2	0.528
RSK4	0.521	-0.067	-3	0.139
TTBK2	0.520	-0.091	2	0.459
DCAMKL1	0.520	-0.069	-3	0.157
CK1A	0.520	-0.036	-3	0.047
BUB1	0.520	0.014	-5	0.500
RIPK3	0.519	-0.088	3	0.517
MEKK3	0.519	-0.105	1	0.514
EEF2K	0.519	-0.014	3	0.616
NEK11	0.519	-0.031	1	0.484
TSSK2	0.518	-0.067	-5	0.500
CK2A1	0.518	-0.006	1	0.505
MSK1	0.518	-0.056	-3	0.145
AMPKA1	0.517	-0.091	-3	0.184
TSSK1	0.517	-0.053	-3	0.191
PKN2	0.517	-0.100	-3	0.174
PLK3	0.517	-0.066	2	0.515
CHAK1	0.517	-0.041	2	0.562
PKACG	0.517	-0.079	-2	0.347
MEKK6	0.517	-0.003	1	0.537
MEKK2	0.517	-0.100	2	0.521
MEK5	0.516	-0.145	2	0.550
RIPK1	0.516	-0.107	1	0.476
MST2	0.516	-0.095	1	0.525
PKACB	0.516	-0.061	-2	0.305
MST3	0.515	-0.088	2	0.587
PLK2	0.515	-0.046	-3	0.220
GCK	0.514	-0.078	1	0.521
CDK6	0.514	0.031	1	0.607
DRAK1	0.514	-0.064	1	0.504
SMMLCK	0.514	-0.077	-3	0.176
MEKK1	0.513	-0.109	1	0.497
TAK1	0.513	-0.078	1	0.506
SGK3	0.513	-0.071	-3	0.138
PAK1	0.513	-0.093	-2	0.393
NEK1	0.513	0.030	1	0.486
AURA	0.513	-0.061	-2	0.279
MYLK4	0.513	-0.078	-2	0.399
MLK3	0.513	-0.107	2	0.458
TNIK	0.512	-0.043	3	0.662
CHK2	0.512	-0.052	-3	0.106
AMPKA2	0.512	-0.086	-3	0.163
TAO3	0.512	-0.128	1	0.500
MINK	0.512	-0.051	1	0.490
MNK2	0.512	-0.070	-2	0.386
NEK4	0.512	0.007	1	0.470
CAMK4	0.511	-0.102	-3	0.179
MLK4	0.511	-0.120	2	0.438
HPK1	0.511	-0.059	1	0.493
NUAK1	0.510	-0.039	-3	0.174
CK1G1	0.510	-0.065	-3	0.072
NEK3	0.510	0.060	1	0.456
AURB	0.510	-0.059	-2	0.287
PAK3	0.510	-0.089	-2	0.391
CDK4	0.510	0.021	1	0.582
DAPK1	0.510	-0.065	-3	0.144
PRKX	0.510	-0.063	-3	0.097
SGK1	0.509	-0.055	-3	0.091
DAPK3	0.509	-0.079	-3	0.150
MEK2	0.509	-0.019	2	0.545
PAK6	0.509	-0.037	-2	0.304
HGK	0.509	-0.044	3	0.652
MSK2	0.509	-0.093	-3	0.144
ZAK	0.509	-0.135	1	0.476
PKCD	0.509	-0.114	2	0.477
LRRK2	0.508	-0.085	2	0.563
PDK1	0.508	-0.093	1	0.477
NIM1	0.508	-0.073	3	0.558
MAP3K15	0.508	-0.075	1	0.466
WNK4	0.507	-0.085	-2	0.475
PKCB	0.507	-0.082	2	0.442
QSK	0.507	-0.065	4	0.514
DCAMKL2	0.507	-0.087	-3	0.166
PKACA	0.507	-0.064	-2	0.278
WNK3	0.507	-0.161	1	0.487
NEK8	0.507	-0.084	2	0.524
CRIK	0.506	-0.054	-3	0.131
P70S6K	0.506	-0.073	-3	0.140
CAMK1D	0.505	-0.085	-3	0.113
IRE1	0.504	-0.110	1	0.484
PKG2	0.504	-0.081	-2	0.298
PKCA	0.503	-0.100	2	0.440
PKCZ	0.503	-0.106	2	0.495
PHKG1	0.503	-0.097	-3	0.158
TAO2	0.503	-0.127	2	0.552
SIK	0.502	-0.080	-3	0.156
MELK	0.502	-0.116	-3	0.159
QIK	0.502	-0.108	-3	0.191
MARK2	0.502	-0.068	4	0.447
CK1G2	0.502	-0.040	-3	0.055
PKCG	0.501	-0.110	2	0.442
PAK2	0.501	-0.116	-2	0.368
PLK4	0.501	-0.103	2	0.372
MST1	0.501	-0.134	1	0.491
KHS1	0.501	-0.069	1	0.477
OSR1	0.500	-0.114	2	0.545
IRAK1	0.500	-0.078	-1	0.529
ROCK2	0.500	-0.085	-3	0.141
MRCKB	0.500	-0.081	-3	0.128
MARK3	0.500	-0.072	4	0.453
KHS2	0.500	-0.066	1	0.490
AKT3	0.499	-0.062	-3	0.101
MNK1	0.499	-0.105	-2	0.391
CAMK1G	0.499	-0.096	-3	0.170
PKCH	0.499	-0.114	2	0.425
AKT1	0.498	-0.076	-3	0.121
DMPK1	0.498	-0.077	-3	0.124
BRSK1	0.497	-0.087	-3	0.169
VRK1	0.496	-0.141	2	0.542
LOK	0.496	-0.099	-2	0.383
YSK1	0.496	-0.073	2	0.539
MRCKA	0.496	-0.095	-3	0.130
MARK1	0.496	-0.080	4	0.470
IRAK4	0.495	-0.115	1	0.478
CAMK1A	0.495	-0.079	-3	0.112
PKCI	0.494	-0.080	2	0.461
PAK5	0.494	-0.069	-2	0.268
ALPHAK3	0.493	-0.078	-1	0.608
IRE2	0.493	-0.134	2	0.438
TTBK1	0.493	-0.105	2	0.388
PKCE	0.492	-0.088	2	0.444
SLK	0.492	-0.119	-2	0.356
BRSK2	0.491	-0.110	-3	0.171
MYO3B	0.491	-0.044	2	0.556
CK1G3	0.490	-0.079	-3	0.033
TTK	0.490	-0.102	-2	0.509
HASPIN	0.490	-0.040	-1	0.538
SSTK	0.489	-0.095	4	0.499
PAK4	0.489	-0.062	-2	0.280
ASK1	0.489	-0.088	1	0.452
STK33	0.489	-0.085	2	0.390
SNRK	0.488	-0.123	2	0.392
BMPR2_TYR	0.488	0.010	-1	0.713
PKN1	0.488	-0.080	-3	0.145
MAP2K4_TYR	0.487	0.033	-1	0.658
MAP2K6_TYR	0.485	-0.011	-1	0.679
PDHK3_TYR	0.485	-0.034	4	0.675
PKCT	0.484	-0.124	2	0.427
ROCK1	0.484	-0.100	-3	0.129
PDHK1_TYR	0.484	-0.002	-1	0.696
RIPK2	0.481	-0.129	1	0.419
BLK	0.481	0.053	-1	0.652
MYO3A	0.481	-0.107	1	0.445
EPHA6	0.480	0.023	-1	0.689
PHKG2	0.479	-0.114	-3	0.163
PKMYT1_TYR	0.479	-0.019	3	0.653
PKG1	0.478	-0.068	-2	0.250
PTK2	0.478	0.043	-1	0.684
LCK	0.478	0.022	-1	0.645
STLK3	0.477	-0.141	1	0.436
EPHB4	0.476	0.002	-1	0.617
YANK3	0.476	-0.073	2	0.255
EPHA4	0.475	-0.006	2	0.539
FGR	0.475	-0.009	1	0.677
HCK	0.475	0.028	-1	0.623
FYN	0.475	0.009	-1	0.625
SYK	0.475	0.015	-1	0.667
ABL2	0.474	0.019	-1	0.591
SRMS	0.474	0.007	1	0.633
TXK	0.473	-0.024	1	0.648
PDHK4_TYR	0.473	-0.117	2	0.615
TESK1_TYR	0.473	-0.102	3	0.673
TAO1	0.472	-0.132	1	0.412
EPHB2	0.471	-0.002	-1	0.605
ABL1	0.471	0.014	-1	0.574
LIMK2_TYR	0.469	-0.068	-3	0.195
FER	0.469	-0.031	1	0.662
EPHB3	0.468	-0.013	-1	0.601
TNK2	0.468	0.003	3	0.563
MAP2K7_TYR	0.468	-0.210	2	0.585
YES1	0.467	-0.043	-1	0.589
EPHB1	0.466	-0.035	1	0.624
SRC	0.465	-0.012	-1	0.591
ITK	0.465	-0.047	-1	0.579
PINK1_TYR	0.464	-0.190	1	0.556
LYN	0.463	-0.009	3	0.523
BMX	0.461	-0.034	-1	0.518
EPHA8	0.460	-0.025	-1	0.628
EPHA7	0.460	-0.034	2	0.522
PTK2B	0.459	-0.012	-1	0.517
JAK2	0.458	-0.083	1	0.509
EPHA3	0.458	-0.051	2	0.496
LIMK1_TYR	0.457	-0.153	2	0.569
YANK2	0.457	-0.084	2	0.264
DDR1	0.457	-0.114	4	0.583
RET	0.457	-0.147	1	0.503
EPHA5	0.456	-0.032	2	0.510
MST1R	0.456	-0.121	3	0.611
MERTK	0.455	-0.049	3	0.579
MET	0.455	-0.088	3	0.587
TYK2	0.454	-0.121	1	0.503
CSF1R	0.453	-0.121	3	0.585
EGFR	0.453	-0.050	1	0.458
FRK	0.453	-0.053	-1	0.652
TYRO3	0.453	-0.132	3	0.582
BTK	0.453	-0.067	-1	0.516
INSRR	0.453	-0.100	3	0.521
EPHA2	0.452	-0.026	-1	0.612
JAK3	0.452	-0.115	1	0.487
ROS1	0.452	-0.124	3	0.547
ERBB4	0.451	-0.029	1	0.509
ERBB2	0.450	-0.081	1	0.509
KIT	0.450	-0.115	3	0.586
TNNI3K_TYR	0.450	-0.051	1	0.557
FLT1	0.450	-0.108	-1	0.681
JAK1	0.449	-0.041	1	0.445
ZAP70	0.449	-0.029	-1	0.587
TEC	0.449	-0.069	-1	0.486
FGFR2	0.449	-0.136	3	0.585
NTRK1	0.449	-0.098	-1	0.565
CSK	0.448	-0.076	2	0.519
NTRK3	0.447	-0.085	-1	0.528
TEK	0.447	-0.111	3	0.520
EPHA1	0.446	-0.069	3	0.576
NEK10_TYR	0.445	-0.075	1	0.372
PTK6	0.445	-0.109	-1	0.482
MATK	0.444	-0.093	-1	0.537
FLT3	0.444	-0.126	3	0.593
KDR	0.443	-0.143	3	0.552
FGFR1	0.443	-0.130	3	0.554
AXL	0.442	-0.115	3	0.556
FGFR3	0.442	-0.124	3	0.553
FGFR4	0.441	-0.090	-1	0.568
TNK1	0.441	-0.100	3	0.585
LTK	0.439	-0.097	3	0.549
PDGFRB	0.439	-0.162	3	0.585
INSR	0.438	-0.109	3	0.505
NTRK2	0.437	-0.129	3	0.526
ALK	0.437	-0.112	3	0.512
FLT4	0.436	-0.139	3	0.549
FES	0.436	-0.043	-1	0.475
WEE1_TYR	0.435	-0.103	-1	0.514
PDGFRA	0.434	-0.161	3	0.589
MUSK	0.434	-0.055	1	0.457
DDR2	0.433	-0.107	3	0.513
IGF1R	0.433	-0.085	3	0.452