Motif 1222 (n=245)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYL0 | TGIF2-C20orf24 | S4 | ochoa | Protein TGIF2-C20orf24 | None |
| A0MZ66 | SHTN1 | S4 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A1L390 | PLEKHG3 | S4 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6ND36 | FAM83G | S4 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A8K855 | EFCAB7 | S4 | ochoa | EF-hand calcium-binding domain-containing protein 7 | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}. |
| C9JLW8 | MCRIP1 | S4 | ochoa | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}. |
| K7EJ46 | SMIM22 | S4 | ochoa | Small integral membrane protein 22 (Cancer-associated small integral membrane open reading frame 1) | May modulate lipid droplet formation throught interaction with SQLE. {ECO:0000269|PubMed:29765154}. |
| O00560 | SDCBP | Y4 | ochoa|psp | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O14920 | IKBKB | S4 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15020 | SPTBN2 | T4 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15294 | OGT | S4 | ochoa|psp | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:26237509, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:34667079, ECO:0000269|PubMed:37541260, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085). {ECO:0000269|PubMed:31527085}. |
| O43167 | ZBTB24 | T4 | ochoa | Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) | May be involved in BMP2-induced transcription. {ECO:0000250}. |
| O43663 | PRC1 | S4 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43707 | ACTN4 | Y4 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43719 | HTATSF1 | T4 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60220 | TIMM8A | S4 | ochoa | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
| O60234 | GMFG | S4 | ochoa|psp | Glia maturation factor gamma (GMF-gamma) | None |
| O60716 | CTNND1 | S4 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75531 | BANF1 | S4 | ochoa|psp | Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] | Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32792394). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (PubMed:32792394). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (PubMed:31796734). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (PubMed:25991860). In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication (PubMed:18005698). {ECO:0000269|PubMed:10908652, ECO:0000269|PubMed:11792822, ECO:0000269|PubMed:12163470, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:25991860, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:9465049}.; FUNCTION: (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome (PubMed:11005805, PubMed:16680152, PubMed:9465049). EMD and BAF are cooperative cofactors of HIV-1 infection (PubMed:16680152). Association of EMD with the viral DNA requires the presence of BAF and viral integrase (PubMed:16680152). The association of viral DNA with chromatin requires the presence of BAF and EMD (PubMed:16680152). {ECO:0000269|PubMed:11005805, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:9465049}. |
| O95677 | EYA4 | S4 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
| P00352 | ALDH1A1 | S4 | ochoa | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
| P00374 | DHFR | S4 | ochoa | Dihydrofolate reductase (EC 1.5.1.3) | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}. |
| P00558 | PGK1 | S4 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P05783 | KRT18 | T4 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06493 | CDK1 | Y4 | psp | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P06748 | NPM1 | S4 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07741 | APRT | S4 | ochoa | Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. {ECO:0000269|PubMed:15196008}. |
| P08473 | MME | S4 | ochoa|psp | Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991, PubMed:6349683). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675, PubMed:6349683). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:16254193, PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:2972276, ECO:0000269|PubMed:6208535, ECO:0000269|PubMed:6349683}. |
| P08651 | NFIC | S4 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P09651 | HNRNPA1 | S4 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P10074 | ZBTB48 | S4 | ochoa | Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (hKR3) (Telomere zinc finger-associated protein) (TZAP) (Telomere-binding protein and transcriptional activator ZBTB48) (Zinc finger protein 855) | Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486). {ECO:0000269|PubMed:24382891, ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257, ECO:0000269|PubMed:39300486, ECO:0000269|PubMed:39562739, ECO:0000269|PubMed:7969177}. |
| P10412 | H1-4 | T4 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P11388 | TOP2A | S4 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12277 | CKB | S4 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P12814 | ACTN1 | Y4 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P14550 | AKR1A1 | S4 | ochoa | Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318, PubMed:30538128). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:11306097, PubMed:18276838). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838, ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033}. |
| P16401 | H1-5 | T4 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | T4 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | T4 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P17096 | HMGA1 | S4 | ochoa | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| P20338 | RAB4A | T4 | ochoa | Ras-related protein Rab-4A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}. |
| P20472 | PVALB | T4 | ochoa | Parvalbumin alpha (Alpha-parvalbumin) (Alpha-PV) | In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (PubMed:15122922, PubMed:39584689). {ECO:0000250|UniProtKB:P02624, ECO:0000269|PubMed:15122922, ECO:0000269|PubMed:39584689}. |
| P22307 | SCP2 | S4 | ochoa | Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X) | [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:10706581}.; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (PubMed:17157249, PubMed:7642518, PubMed:8300590). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:7642518, ECO:0000269|PubMed:8300590}. |
| P22314 | UBA1 | S4 | ochoa|psp | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P22626 | HNRNPA2B1 | T4 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23381 | WARS1 | S4 | ochoa | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| P25205 | MCM3 | T4 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P35998 | PSMC2 | Y4 | ochoa | 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}. |
| P37837 | TALDO1 | S4 | ochoa | Transaldolase (EC 2.2.1.2) | Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}. |
| P41212 | ETV6 | T4 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P42025 | ACTR1B | Y4 | ochoa | Beta-centractin (Actin-related protein 1B) (ARP1B) | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| P43243 | MATR3 | S4 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P47974 | ZFP36L2 | T4 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48048 | KCNJ1 | S4 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48729 | CSNK1A1 | S4 | ochoa | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49902 | NT5C2 | S4 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50402 | EMD | Y4 | psp | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50749 | RASSF2 | S4 | ochoa | Ras association domain-containing protein 2 | Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}. |
| P51157 | RAB28 | S4 | ochoa | Ras-related protein Rab-28 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:8647132). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:8647132). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (By similarity). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (By similarity). {ECO:0000250|UniProtKB:P51158, ECO:0000250|UniProtKB:Q99KL7, ECO:0000269|PubMed:8647132}. |
| P51452 | DUSP3 | S4 | ochoa | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}. |
| P54578 | USP14 | Y4 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55160 | NCKAP1L | T4 | ochoa | Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) | Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000269|PubMed:32647003, ECO:0000303|PubMed:20969869}. |
| P60842 | EIF4A1 | S4 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P61163 | ACTR1A | Y4 | ochoa | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| P62136 | PPP1CA | S4 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62995 | TRA2B | S4 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P63010 | AP2B1 | S4 | ochoa | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P63172 | DYNLT1 | Y4 | ochoa | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274). {ECO:0000250, ECO:0000269|PubMed:27502274}.; FUNCTION: (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}. |
| P63218 | GNG5 | S4 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| P67870 | CSNK2B | S4 | ochoa|psp | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}. |
| P69905 | HBA1; | S4 | ochoa | Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] | Involved in oxygen transport from the lung to the various peripheral tissues.; FUNCTION: [Hemopressin]: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling (PubMed:18077343). {ECO:0000269|PubMed:18077343}. |
| Q00839 | HNRNPU | S4 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q01581 | HMGCS1 | S4 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q02539 | H1-1 | T4 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q06265 | EXOSC9 | T4 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q08050 | FOXM1 | S4 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08945 | SSRP1 | T4 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q13148 | TARDBP | Y4 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13336 | SLC14A1 | S4 | ochoa | Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte) | Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:10514515, PubMed:7797558, PubMed:7989337, PubMed:8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VHL0, ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:7797558, ECO:0000269|PubMed:7989337, ECO:0000269|PubMed:8997401}. |
| Q13573 | SNW1 | T4 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13835 | PKP1 | S4 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14004 | CDK13 | S4 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14676 | MDC1 | T4 | ochoa|psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15124 | PGM5 | S4 | ochoa | Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) | Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}. |
| Q15172 | PPP2R5A | S4 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q16543 | CDC37 | Y4 | ochoa|psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q2M2I3 | FAM83E | S4 | ochoa | Protein FAM83E | May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}. |
| Q3ZCW2 | LGALSL | S4 | ochoa | Galectin-related protein (Galectin-like protein) (Lectin galactoside-binding-like protein) | Does not bind lactose, and may not bind carbohydrates. {ECO:0000269|PubMed:18320588, ECO:0000269|PubMed:18433051}. |
| Q4VCS5 | AMOT | S4 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q53QZ3 | ARHGAP15 | S4 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5SY16 | NOL9 | S4 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T0W9 | FAM83B | S4 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T7W7 | TSTD2 | S4 | ochoa | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) | None |
| Q5TGZ0 | MICOS10 | S4 | ochoa | MICOS complex subunit MIC10 (Mitochondrial inner membrane organizing system protein 1) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q5VZM2 | RRAGB | S4 | ochoa | Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:9394008}. |
| Q6P1Q9 | METTL2B | S4 | ochoa | tRNA N(3)-cytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B) | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269|PubMed:28655767}. |
| Q6SZW1 | SARM1 | T4 | ochoa | NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439792, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). {ECO:0000250|UniProtKB:Q6PDS3, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:16964262, ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:25908823, ECO:0000269|PubMed:27671644, ECO:0000269|PubMed:28334607, ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:30333228, ECO:0000269|PubMed:31128467, ECO:0000269|PubMed:31439792, ECO:0000269|PubMed:31439793, ECO:0000269|PubMed:32049506, ECO:0000269|PubMed:32828421, ECO:0000269|PubMed:33053563}. |
| Q6ZN04 | MEX3B | S4 | ochoa | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. |
| Q6ZU80 | CEP128 | S4 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q75N03 | CBLL1 | T4 | ochoa | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. |
| Q7RTX9 | SLC16A14 | S4 | ochoa | Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) | Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. {ECO:0000250}. |
| Q7Z3U7 | MON2 | T4 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q7Z4I7 | LIMS2 | S4 | ochoa | LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) | Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269|PubMed:12167643}. |
| Q86SQ7 | SDCCAG8 | S4 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
| Q86WA9 | SLC26A11 | S4 | ochoa | Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) | Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport (By similarity). Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC) (PubMed:12626430). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion (By similarity). May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum (By similarity). {ECO:0000250|UniProtKB:G3C7W6, ECO:0000250|UniProtKB:Q80ZD3, ECO:0000269|PubMed:12626430}. |
| Q8N165 | PDIK1L | S4 | ochoa | Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) | None |
| Q8N5C8 | TAB3 | S4 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N5U6 | RNF10 | S4 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8NEE8 | TTC16 | S4 | ochoa | Tetratricopeptide repeat protein 16 (TPR repeat protein 16) | None |
| Q8NEG4 | FAM83F | S4 | ochoa | Protein FAM83F | None |
| Q8NFQ8 | TOR1AIP2 | S4 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NHC7 | OR14C36 | S4 | ochoa | Olfactory receptor 14C36 (Olfactory receptor 5BF1) (Olfactory receptor OR1-59) | Odorant receptor. {ECO:0000305}. |
| Q8NI77 | KIF18A | T4 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TBE7 | SLC35G2 | S4 | ochoa | Solute carrier family 35 member G2 (Transmembrane protein 22) | None |
| Q8WV07 | LTO1 | S4 | ochoa | Protein LTO1 homolog (Oral cancer-overexpressed protein 1) (Tumor-amplified and overexpressed sequence 1) | The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). {ECO:0000269|PubMed:23318452, ECO:0000269|PubMed:24930674, ECO:0000269|PubMed:26182403}. |
| Q8WVV9 | HNRNPLL | S4 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q8WXH0 | SYNE2 | S4 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92609 | TBC1D5 | S4 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92698 | RAD54L | S4 | ochoa | DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) | Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989, ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312, ECO:0000269|PubMed:9774452}. |
| Q96A57 | TMEM230 | S4 | ochoa | Transmembrane protein 230 | Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}. |
| Q96BD8 | SKA1 | S4 | ochoa | SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) | Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (PubMed:17093495, PubMed:19289083, PubMed:22371557, PubMed:22483620, PubMed:23085020, PubMed:26981768, PubMed:27697923, PubMed:29487209, PubMed:31804178). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:28479321, PubMed:29487209). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17093495, PubMed:19289083, PubMed:23085020, PubMed:28479321, PubMed:29487209). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (PubMed:19289083, PubMed:22371557, PubMed:22454517, PubMed:23085020, PubMed:24413531, PubMed:27697923, PubMed:28479321, PubMed:28495837, PubMed:29487209). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (PubMed:23085020, PubMed:29153323). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (PubMed:26981768). In the complex, it mediates interactions with microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:24413531, PubMed:27667719, PubMed:29153323, PubMed:36592928). It also stimulates AURKB/Aurora B catalytic activity (PubMed:27697923). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q9CPV1, ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:22371557, ECO:0000269|PubMed:22454517, ECO:0000269|PubMed:22483620, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:24413531, ECO:0000269|PubMed:26981768, ECO:0000269|PubMed:27667719, ECO:0000269|PubMed:27697923, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:28495837, ECO:0000269|PubMed:29153323, ECO:0000269|PubMed:29487209, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:36592928}. |
| Q96EP5 | DAZAP1 | S4 | ochoa | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q96FV9 | THOC1 | T4 | ochoa | THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96IY1 | NSL1 | S4 | ochoa | Kinetochore-associated protein NSL1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}. |
| Q96IZ6 | METTL2A | S4 | ochoa | tRNA N(3)-cytidine methyltransferase METTL2A (EC 2.1.1.-) (Methyltransferase-like protein 2A) | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557). {ECO:0000269|PubMed:28655767, ECO:0000269|PubMed:34268557}. |
| Q96J02 | ITCH | S4 | ochoa | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}. |
| Q96QK1 | VPS35 | T4 | ochoa | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. |
| Q99439 | CNN2 | T4 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99471 | PFDN5 | S4 | ochoa | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269|PubMed:9630229}. |
| Q99626 | CDX2 | S4 | ochoa | Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}. |
| Q9BTU6 | PI4K2A | T4 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BU19 | ZNF692 | S4 | ochoa | Zinc finger protein 692 (AICAR responsive element binding protein) | May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}. |
| Q9BX40 | LSM14B | S4 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BXP5 | SRRT | S4 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BY11 | PACSIN1 | S4 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9BY44 | EIF2A | S4 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9C0B1 | FTO | T4 | ochoa|psp | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9GZN2 | TGIF2 | S4 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
| Q9HAS0 | C17orf75 | S4 | ochoa | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
| Q9NP77 | SSU72 | S4 | ochoa|psp | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) | Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}. |
| Q9NP98 | MYOZ1 | S4 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NQ86 | TRIM36 | S4 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NVT9 | ARMC1 | S4 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NW15 | ANO10 | T4 | ochoa | Anoctamin-10 (Transmembrane protein 16K) | Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}. |
| Q9NW64 | RBM22 | S4 | ochoa | Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. |
| Q9NYF5 | FAM13B | S4 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9UGP4 | LIMD1 | Y4 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHB6 | LIMA1 | S4 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHD2 | TBK1 | T4 | ochoa | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UIU6 | SIX4 | S4 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UJ83 | HACL1 | S4 | ochoa | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) | Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}. |
| Q9UKC9 | FBXL2 | S4 | ochoa | F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3) | Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22020328, PubMed:22323446). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (PubMed:22020328, PubMed:22323446). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (PubMed:22020328, PubMed:22323446). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (PubMed:26037928). {ECO:0000250|UniProtKB:Q8BH16, ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:22323446, ECO:0000269|PubMed:23604317, ECO:0000269|PubMed:26037928}. |
| Q9ULS5 | TMCC3 | S4 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UM01 | SLC7A7 | S4 | ochoa | Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}. |
| Q9UNF1 | MAGED2 | T4 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UNQ0 | ABCG2 | S4 | ochoa | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response. {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000269|PubMed:38181789, ECO:0000305|PubMed:12958161}. |
| Q9Y277 | VDAC3 | T4 | ochoa | Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). {ECO:0000250|UniProtKB:Q60931, ECO:0000269|PubMed:31935282}. |
| Q9Y3I0 | RTCB | S4 | ochoa | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) | Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}. |
| Q9Y483 | MTF2 | S4 | ochoa | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}. |
| Q9Y5A9 | YTHDF2 | S4 | ochoa | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:31642031, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}. |
| Q9Y5Z9 | UBIAD1 | S4 | ochoa | UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Transitional epithelial response protein 1) | Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 (PubMed:20953171, PubMed:23374346). MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development (PubMed:20953171). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (PubMed:20953171). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system (PubMed:23374346). Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (PubMed:23374346). {ECO:0000269|PubMed:20953171, ECO:0000269|PubMed:23374346}. |
| Q9Y620 | RAD54B | S4 | ochoa | DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) | Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632}. |
| Q9Y696 | CLIC4 | S4 | ochoa | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
| Q7LDG7 | RASGRP2 | T4 | Sugiyama | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| P62241 | RPS8 | S4 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P18621 | RPL17 | Y4 | Sugiyama | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O75190 | DNAJB6 | Y4 | Sugiyama | DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:28233300}.; FUNCTION: [Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation. {ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}. |
| A0A0A6YYG9 | ARPC4-TTLL3 | T4 | ochoa | Protein ARPC4-TTLL3 | None |
| O15400 | STX7 | T4 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| P09211 | GSTP1 | Y4 | psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P16157 | ANK1 | S4 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P35659 | DEK | S4 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P43007 | SLC1A4 | S4 | ochoa | Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) | Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}. |
| P57740 | NUP107 | S4 | ochoa | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
| P58012 | FOXL2 | S4 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P59998 | ARPC4 | T4 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| Q01959 | SLC6A3 | S4 | psp | Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:1406597, ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:19478460, ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0000269|PubMed:8302271}. |
| Q06330 | RBPJ | T4 | ochoa | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250|UniProtKB:P31266, ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}. |
| Q13206 | DDX10 | T4 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13542 | EIF4EBP2 | S4 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q16186 | ADRM1 | S4 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q5VV17 | OTUD1 | Y4 | ochoa | OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) | Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36445135}. |
| Q6P474 | PDXDC2P | S4 | ochoa | Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC 4.1.1.-) (pyridoxal-dependent decarboxylase domain-containing 2 pseudogene) | None |
| Q6P996 | PDXDC1 | S4 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q8N697 | SLC15A4 | S4 | ochoa | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}. |
| Q92945 | KHSRP | Y4 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96HU1 | SGSM3 | S4 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96NT5 | SLC46A1 | S4 | ochoa | Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) | Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:19762432, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:31792273, PubMed:32893190, PubMed:34619546). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:32893190). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:32893190, PubMed:34040256). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases (PubMed:18524888, PubMed:19762432, PubMed:22345511, PubMed:25608532, PubMed:28802835, PubMed:29326243, PubMed:34040256, PubMed:34619546). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (PubMed:19074442). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:17156779). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:32621820). Hence, participates in the trafficking of heme and increases intracellular iron content (PubMed:32621820). {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902, ECO:0000269|PubMed:18524888, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:19389703, ECO:0000269|PubMed:19762432, ECO:0000269|PubMed:22345511, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:25608532, ECO:0000269|PubMed:28802835, ECO:0000269|PubMed:29326243, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:31494288, ECO:0000269|PubMed:31792273, ECO:0000269|PubMed:32621820, ECO:0000269|PubMed:32893190, ECO:0000269|PubMed:34040256, ECO:0000269|PubMed:34619546}.; FUNCTION: [Isoform 2]: Inactive isoform which is not able to mediate proton-coupled folate transport. {ECO:0000269|PubMed:17129779}. |
| Q9BR77 | CCDC77 | T4 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BVC4 | MLST8 | S4 | ochoa | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) | Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}. |
| Q9H0W8 | SMG9 | S4 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H3U1 | UNC45A | S4 | ochoa | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993, ECO:0000305}. |
| Q9H6S3 | EPS8L2 | S4 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9NZ32 | ACTR10 | Y4 | ochoa | Actin-related protein 10 (Actin-related protein 11) (hARP11) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:I3LHK5}. |
| Q9UJV9 | DDX41 | S4 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKY7 | CDV3 | T4 | ochoa | Protein CDV3 homolog | None |
| Q9UPQ4 | TRIM35 | S4 | ochoa | E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}. |
| Q9Y210 | TRPC6 | S4 | ochoa|psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y421 | FAM32A | Y4 | ochoa | Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12) | Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. {ECO:0000269|PubMed:21339736}. |
| P68431 | H3C1 | T4 | GPS6|SIGNOR|EPSD | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P84243 | H3-3A | T4 | GPS6|EPSD | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q16695 | H3-4 | T4 | GPS6 | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q71DI3 | H3C15 | T4 | GPS6|EPSD | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| B2RXF0 | TMEM229A | S4 | ochoa | Transmembrane protein 229A | None |
| M0R2N4 | None | Y4 | ochoa | C3H1-type domain-containing protein | None |
| O15160 | POLR1C | S4 | ochoa | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft. {ECO:0000250|UniProtKB:P07703, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000305|PubMed:26151409}. |
| O60869 | EDF1 | S4 | ochoa | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}. |
| O75381 | PEX14 | S4 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75410 | TACC1 | S4 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75694 | NUP155 | S4 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O95456 | PSMG1 | T4 | ochoa | Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| P15927 | RPA2 | S4 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P16949 | STMN1 | S4 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P28347 | TEAD1 | S4 | ochoa | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| P49736 | MCM2 | S4 | ochoa|psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P54819 | AK2 | S4 | ochoa | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| P57088 | TMEM33 | T4 | ochoa | Transmembrane protein 33 (Protein DB83) (SHINC-3) | Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377). {ECO:0000250|UniProtKB:Q9CR67, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696, ECO:0000269|PubMed:30760708, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34487377}. |
| Q01081 | U2AF1 | Y4 | ochoa | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
| Q01658 | DR1 | S4 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q02978 | SLC25A11 | T4 | ochoa | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) | Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). {ECO:0000250|UniProtKB:P22292, ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:21448454}. |
| Q04941 | PLP2 | S4 | ochoa | Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein) | May play a role in cell differentiation in the intestinal epithelium. |
| Q13077 | TRAF1 | S4 | ochoa | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
| Q16637 | SMN1 | S4 | ochoa|psp | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q5RL73 | RBM48 | S4 | ochoa | RNA-binding protein 48 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000305|PubMed:33509932}. |
| Q68CP9 | ARID2 | S4 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q6P1A2 | LPCAT3 | S4 | ochoa | Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) | Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18195019, PubMed:18772128, PubMed:18782225). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18195019, PubMed:18772128, PubMed:18782225). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250|UniProtKB:Q91V01, ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225}. |
| Q6UUV7 | CRTC3 | S4 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q7L4I2 | RSRC2 | S4 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7Z591 | AKNA | S4 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q8IV50 | LYSMD2 | S4 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IV56 | PRR15 | S4 | ochoa | Proline-rich protein 15 | May have a role in proliferation and/or differentiation. {ECO:0000250}. |
| Q8TF42 | UBASH3B | Y4 | ochoa | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}. |
| Q8TF76 | HASPIN | S4 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WU68 | U2AF1L4 | Y4 | ochoa | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Q92599 | SEPTIN8 | T4 | ochoa | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q96AY4 | TTC28 | S4 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q99708 | RBBP8 | S4 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q9BPY3 | FAM118B | T4 | ochoa | Protein FAM118B | May play a role in Cajal bodies formation. {ECO:0000269|PubMed:24569877}. |
| Q9BSJ8 | ESYT1 | S4 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BW30 | TPPP3 | S4 | ochoa | Tubulin polymerization-promoting protein family member 3 (TPPP/p20) | Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (PubMed:30667362). {ECO:0000250|UniProtKB:Q9CRB6, ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818, ECO:0000269|PubMed:30667362}. |
| Q9NRG1 | PRTFDC1 | S4 | ochoa | Phosphoribosyltransferase domain-containing protein 1 | Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. |
| Q9NVD7 | PARVA | S4 | ochoa|psp | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9P1Q0 | VPS54 | S4 | ochoa | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q9P289 | STK26 | S4 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9Y530 | OARD1 | S4 | ochoa | ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-) | ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23474714, PubMed:23481255). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506). {ECO:0000269|PubMed:21849506, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 7.175921e-09 | 8.144 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.848654e-07 | 6.733 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.854932e-07 | 6.164 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 3.944913e-06 | 5.404 |
| R-HSA-2262752 | Cellular responses to stress | 5.609565e-06 | 5.251 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.040712e-06 | 5.095 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.008777e-05 | 4.996 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.159052e-05 | 4.936 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.475579e-05 | 4.831 |
| R-HSA-1500620 | Meiosis | 4.506034e-05 | 4.346 |
| R-HSA-69206 | G1/S Transition | 4.321456e-05 | 4.364 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.795806e-05 | 4.421 |
| R-HSA-69481 | G2/M Checkpoints | 4.900298e-05 | 4.310 |
| R-HSA-75153 | Apoptotic execution phase | 5.335526e-05 | 4.273 |
| R-HSA-912446 | Meiotic recombination | 9.215885e-05 | 4.035 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 9.726571e-05 | 4.012 |
| R-HSA-68886 | M Phase | 1.019640e-04 | 3.992 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.130193e-04 | 3.947 |
| R-HSA-68875 | Mitotic Prophase | 1.449387e-04 | 3.839 |
| R-HSA-5357801 | Programmed Cell Death | 1.931801e-04 | 3.714 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.438680e-04 | 3.613 |
| R-HSA-69306 | DNA Replication | 2.439564e-04 | 3.613 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.869476e-04 | 3.542 |
| R-HSA-446728 | Cell junction organization | 2.770974e-04 | 3.557 |
| R-HSA-1500931 | Cell-Cell communication | 3.210025e-04 | 3.493 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.225251e-04 | 3.374 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.126098e-04 | 3.384 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.644832e-04 | 3.333 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.585471e-04 | 3.339 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.308068e-04 | 3.275 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.352312e-04 | 3.197 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.352312e-04 | 3.197 |
| R-HSA-72172 | mRNA Splicing | 6.543981e-04 | 3.184 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 7.123274e-04 | 3.147 |
| R-HSA-2559583 | Cellular Senescence | 8.475410e-04 | 3.072 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.023727e-03 | 2.990 |
| R-HSA-418990 | Adherens junctions interactions | 1.095754e-03 | 2.960 |
| R-HSA-1474165 | Reproduction | 1.183350e-03 | 2.927 |
| R-HSA-176974 | Unwinding of DNA | 1.284029e-03 | 2.891 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.346053e-03 | 2.871 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.918266e-03 | 2.717 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.657989e-03 | 2.575 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.823205e-03 | 2.549 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.823205e-03 | 2.549 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.828506e-03 | 2.548 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.007084e-03 | 2.522 |
| R-HSA-68882 | Mitotic Anaphase | 3.170591e-03 | 2.499 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.272081e-03 | 2.485 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.389356e-03 | 2.470 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.174000e-03 | 2.498 |
| R-HSA-421270 | Cell-cell junction organization | 3.161594e-03 | 2.500 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.170278e-03 | 2.499 |
| R-HSA-5334118 | DNA methylation | 3.477540e-03 | 2.459 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.806683e-03 | 2.419 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.806683e-03 | 2.419 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.260956e-03 | 2.370 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.271953e-03 | 2.369 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.662045e-03 | 2.331 |
| R-HSA-69190 | DNA strand elongation | 4.641204e-03 | 2.333 |
| R-HSA-8953854 | Metabolism of RNA | 4.451736e-03 | 2.351 |
| R-HSA-195721 | Signaling by WNT | 4.222688e-03 | 2.374 |
| R-HSA-1538133 | G0 and Early G1 | 4.641204e-03 | 2.333 |
| R-HSA-109581 | Apoptosis | 4.705514e-03 | 2.327 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.754077e-03 | 2.323 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.080742e-03 | 2.294 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.080742e-03 | 2.294 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.080742e-03 | 2.294 |
| R-HSA-75893 | TNF signaling | 5.580240e-03 | 2.253 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.946991e-03 | 2.226 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.041708e-03 | 2.219 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.330389e-03 | 2.199 |
| R-HSA-69205 | G1/S-Specific Transcription | 7.116523e-03 | 2.148 |
| R-HSA-447115 | Interleukin-12 family signaling | 7.153190e-03 | 2.146 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 7.698303e-03 | 2.114 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 7.698303e-03 | 2.114 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 8.310519e-03 | 2.080 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 8.038025e-03 | 2.095 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.635275e-03 | 2.064 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 8.797021e-03 | 2.056 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.797021e-03 | 2.056 |
| R-HSA-427975 | Proton/oligopeptide cotransporters | 8.797021e-03 | 2.056 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 9.628708e-03 | 2.016 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 9.628708e-03 | 2.016 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 9.628708e-03 | 2.016 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.004178e-02 | 1.998 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.100784e-02 | 1.958 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.033585e-02 | 1.986 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.033585e-02 | 1.986 |
| R-HSA-447043 | Neurofascin interactions | 1.100784e-02 | 1.958 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.100784e-02 | 1.958 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.125086e-02 | 1.949 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.183015e-02 | 1.927 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.209068e-02 | 1.918 |
| R-HSA-3214847 | HATs acetylate histones | 1.328310e-02 | 1.877 |
| R-HSA-68877 | Mitotic Prometaphase | 1.281027e-02 | 1.892 |
| R-HSA-9959399 | SLC-mediated transport of oligopeptides | 1.343648e-02 | 1.872 |
| R-HSA-9710421 | Defective pyroptosis | 1.265604e-02 | 1.898 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.299697e-02 | 1.886 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.365137e-02 | 1.865 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.432761e-02 | 1.844 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.432761e-02 | 1.844 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.528485e-02 | 1.816 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.607484e-02 | 1.794 |
| R-HSA-9766229 | Degradation of CDH1 | 1.823426e-02 | 1.739 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.742861e-02 | 1.759 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.804663e-02 | 1.744 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.740142e-02 | 1.759 |
| R-HSA-69239 | Synthesis of DNA | 1.875958e-02 | 1.727 |
| R-HSA-211000 | Gene Silencing by RNA | 1.875958e-02 | 1.727 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.891501e-02 | 1.723 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.055807e-02 | 1.687 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.144339e-02 | 1.669 |
| R-HSA-6798695 | Neutrophil degranulation | 2.139426e-02 | 1.670 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.945044e-02 | 1.711 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.088377e-02 | 1.680 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.088377e-02 | 1.680 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.969699e-02 | 1.706 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.974768e-02 | 1.704 |
| R-HSA-9833482 | PKR-mediated signaling | 1.969699e-02 | 1.706 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.194930e-02 | 1.659 |
| R-HSA-164843 | 2-LTR circle formation | 2.194930e-02 | 1.659 |
| R-HSA-1221632 | Meiotic synapsis | 2.268282e-02 | 1.644 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.316543e-02 | 1.635 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.381904e-02 | 1.623 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.517023e-02 | 1.599 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.517023e-02 | 1.599 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.517023e-02 | 1.599 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.517023e-02 | 1.599 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.523159e-02 | 1.598 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.523159e-02 | 1.598 |
| R-HSA-4839744 | Signaling by APC mutants | 2.517023e-02 | 1.599 |
| R-HSA-373760 | L1CAM interactions | 2.732998e-02 | 1.563 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.401083e-02 | 1.620 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.857051e-02 | 1.544 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 3.214305e-02 | 1.493 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 3.214305e-02 | 1.493 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 3.214305e-02 | 1.493 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 3.214305e-02 | 1.493 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 3.214305e-02 | 1.493 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.773837e-02 | 1.557 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.049823e-02 | 1.516 |
| R-HSA-162592 | Integration of provirus | 2.857051e-02 | 1.544 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 3.214305e-02 | 1.493 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.857051e-02 | 1.544 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.857051e-02 | 1.544 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.857051e-02 | 1.544 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.193675e-02 | 1.496 |
| R-HSA-3371556 | Cellular response to heat stress | 3.196263e-02 | 1.495 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.196263e-02 | 1.495 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.857051e-02 | 1.544 |
| R-HSA-73886 | Chromosome Maintenance | 3.196263e-02 | 1.495 |
| R-HSA-162906 | HIV Infection | 3.038184e-02 | 1.517 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.857051e-02 | 1.544 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 3.214305e-02 | 1.493 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.974517e-02 | 1.527 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.196263e-02 | 1.495 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.224001e-02 | 1.492 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.341451e-02 | 1.476 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.395042e-02 | 1.469 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.395042e-02 | 1.469 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.418047e-02 | 1.466 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.418047e-02 | 1.466 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.418047e-02 | 1.466 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.418047e-02 | 1.466 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.418047e-02 | 1.466 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.552666e-02 | 1.449 |
| R-HSA-5205647 | Mitophagy | 3.552666e-02 | 1.449 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.552666e-02 | 1.449 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 4.382607e-02 | 1.358 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.771805e-02 | 1.423 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 4.382607e-02 | 1.358 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.941610e-02 | 1.404 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.486297e-02 | 1.348 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.310897e-02 | 1.365 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 4.382607e-02 | 1.358 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.155486e-02 | 1.381 |
| R-HSA-157118 | Signaling by NOTCH | 3.990604e-02 | 1.399 |
| R-HSA-381042 | PERK regulates gene expression | 3.771805e-02 | 1.423 |
| R-HSA-157579 | Telomere Maintenance | 4.174387e-02 | 1.379 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.940089e-02 | 1.404 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.174387e-02 | 1.379 |
| R-HSA-5218859 | Regulated Necrosis | 4.486297e-02 | 1.348 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.771805e-02 | 1.423 |
| R-HSA-5619081 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 5.083161e-02 | 1.294 |
| R-HSA-9734195 | Defective APRT disrupts adenine salvage | 5.083161e-02 | 1.294 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 5.083161e-02 | 1.294 |
| R-HSA-5660724 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 5.083161e-02 | 1.294 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 5.083161e-02 | 1.294 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.083161e-02 | 1.294 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.083161e-02 | 1.294 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 4.802042e-02 | 1.319 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.848934e-02 | 1.314 |
| R-HSA-5635838 | Activation of SMO | 4.802042e-02 | 1.319 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.491921e-02 | 1.260 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 4.802042e-02 | 1.319 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.596408e-02 | 1.338 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 5.235432e-02 | 1.281 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.848934e-02 | 1.314 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 5.083161e-02 | 1.294 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 5.235432e-02 | 1.281 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.621337e-02 | 1.250 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.967810e-02 | 1.304 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.891381e-02 | 1.311 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.491921e-02 | 1.260 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.491921e-02 | 1.260 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.848934e-02 | 1.314 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.226667e-02 | 1.282 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.742529e-02 | 1.324 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.227306e-02 | 1.282 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 4.802042e-02 | 1.319 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 4.802042e-02 | 1.319 |
| R-HSA-74160 | Gene expression (Transcription) | 5.661787e-02 | 1.247 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.676680e-02 | 1.246 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 5.763500e-02 | 1.239 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.719667e-02 | 1.173 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.719667e-02 | 1.173 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.719667e-02 | 1.173 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.719667e-02 | 1.173 |
| R-HSA-1296067 | Potassium transport channels | 6.719667e-02 | 1.173 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.719667e-02 | 1.173 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.719667e-02 | 1.173 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.719667e-02 | 1.173 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.719667e-02 | 1.173 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.719667e-02 | 1.173 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.719667e-02 | 1.173 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.719667e-02 | 1.173 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 8.328057e-02 | 1.079 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.146240e-01 | 0.941 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.298930e-01 | 0.886 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 1.298930e-01 | 0.886 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.448995e-01 | 0.839 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.448995e-01 | 0.839 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.448995e-01 | 0.839 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.448995e-01 | 0.839 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.596482e-01 | 0.797 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 6.141684e-02 | 1.212 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.883894e-01 | 0.725 |
| R-HSA-350054 | Notch-HLH transcription pathway | 8.611357e-02 | 1.065 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.429662e-01 | 0.614 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.429662e-01 | 0.614 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.132121e-01 | 0.946 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.132121e-01 | 0.946 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.245941e-01 | 0.905 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.303845e-01 | 0.885 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.362358e-01 | 0.866 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.362358e-01 | 0.866 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.481064e-01 | 0.829 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.481064e-01 | 0.829 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 8.808988e-02 | 1.055 |
| R-HSA-72187 | mRNA 3'-end processing | 8.808988e-02 | 1.055 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.541184e-01 | 0.812 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.601768e-01 | 0.795 |
| R-HSA-72649 | Translation initiation complex formation | 9.485306e-02 | 1.023 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.018221e-01 | 0.992 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.724196e-01 | 0.763 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.126436e-01 | 0.948 |
| R-HSA-191859 | snRNP Assembly | 1.126436e-01 | 0.948 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.910510e-01 | 0.719 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.973208e-01 | 0.705 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.277150e-01 | 0.894 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.277150e-01 | 0.894 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.394630e-01 | 0.856 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.681810e-01 | 0.774 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.417604e-01 | 0.617 |
| R-HSA-380287 | Centrosome maturation | 1.766834e-01 | 0.753 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.581815e-01 | 0.801 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.390042e-01 | 0.622 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.920568e-01 | 0.717 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.303845e-01 | 0.885 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.920568e-01 | 0.717 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.279593e-01 | 0.642 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.279593e-01 | 0.642 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 7.591202e-02 | 1.120 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.481064e-01 | 0.829 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.089888e-01 | 0.963 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.279593e-01 | 0.642 |
| R-HSA-3214842 | HDMs demethylate histones | 1.021227e-01 | 0.991 |
| R-HSA-3214815 | HDACs deacetylate histones | 9.831236e-02 | 1.007 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.036154e-01 | 0.691 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.359427e-01 | 0.867 |
| R-HSA-5693538 | Homology Directed Repair | 8.237504e-02 | 1.084 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.132121e-01 | 0.946 |
| R-HSA-774815 | Nucleosome assembly | 2.353703e-01 | 0.628 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.353703e-01 | 0.628 |
| R-HSA-9930044 | Nuclear RNA decay | 1.481064e-01 | 0.829 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.075196e-02 | 1.150 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.453113e-01 | 0.838 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.453113e-01 | 0.838 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.724196e-01 | 0.763 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.826085e-02 | 1.106 |
| R-HSA-69275 | G2/M Transition | 1.497818e-01 | 0.825 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.146240e-01 | 0.941 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.741433e-01 | 0.759 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 6.613392e-02 | 1.180 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 7.591202e-02 | 1.120 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.296748e-01 | 0.639 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.481064e-01 | 0.829 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.601768e-01 | 0.795 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.581815e-01 | 0.801 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.545369e-01 | 0.811 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 7.213487e-02 | 1.142 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.018353e-02 | 1.096 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.596482e-01 | 0.797 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.076287e-01 | 0.968 |
| R-HSA-4839726 | Chromatin organization | 1.001410e-01 | 0.999 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 1.421444e-01 | 0.847 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.036154e-01 | 0.691 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.188686e-01 | 0.925 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.601768e-01 | 0.795 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 6.141684e-02 | 1.212 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 9.831236e-02 | 1.007 |
| R-HSA-9033241 | Peroxisomal protein import | 1.126436e-01 | 0.948 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.018221e-01 | 0.992 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 6.719667e-02 | 1.173 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 8.328057e-02 | 1.079 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 1.298930e-01 | 0.886 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.298930e-01 | 0.886 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.298930e-01 | 0.886 |
| R-HSA-8875656 | MET receptor recycling | 1.741433e-01 | 0.759 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 6.141684e-02 | 1.212 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.023905e-01 | 0.694 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.023905e-01 | 0.694 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.296748e-01 | 0.639 |
| R-HSA-202670 | ERKs are inactivated | 2.296748e-01 | 0.639 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.429662e-01 | 0.614 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.429662e-01 | 0.614 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.362358e-01 | 0.866 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.421444e-01 | 0.847 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 8.478802e-02 | 1.072 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 9.144523e-02 | 1.039 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.601768e-01 | 0.795 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.162687e-01 | 0.665 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.353703e-01 | 0.628 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.179900e-01 | 0.928 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.417604e-01 | 0.617 |
| R-HSA-9711097 | Cellular response to starvation | 1.940799e-01 | 0.712 |
| R-HSA-165159 | MTOR signalling | 2.162687e-01 | 0.665 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.325323e-02 | 1.199 |
| R-HSA-9609507 | Protein localization | 1.793637e-01 | 0.746 |
| R-HSA-9907900 | Proteasome assembly | 6.325323e-02 | 1.199 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 6.613392e-02 | 1.180 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.162668e-01 | 0.665 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.809788e-01 | 0.742 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.741433e-01 | 0.759 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.883894e-01 | 0.725 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.296748e-01 | 0.639 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.481064e-01 | 0.829 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 8.478802e-02 | 1.072 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.541184e-01 | 0.812 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.848089e-01 | 0.733 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 8.096242e-02 | 1.092 |
| R-HSA-8852135 | Protein ubiquitination | 1.766834e-01 | 0.753 |
| R-HSA-9824272 | Somitogenesis | 6.615405e-02 | 1.179 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.540185e-01 | 0.812 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.598037e-01 | 0.796 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.598037e-01 | 0.796 |
| R-HSA-2161517 | Abacavir transmembrane transport | 1.448995e-01 | 0.839 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.596482e-01 | 0.797 |
| R-HSA-9734207 | Nucleotide salvage defects | 1.741433e-01 | 0.759 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 9.669843e-02 | 1.015 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.421444e-01 | 0.847 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.662783e-01 | 0.779 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.662783e-01 | 0.779 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.099323e-01 | 0.678 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.581815e-01 | 0.801 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.521310e-02 | 1.124 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.355068e-01 | 0.868 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.188239e-02 | 1.143 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.132121e-01 | 0.946 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.245941e-01 | 0.905 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.303845e-01 | 0.885 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.662783e-01 | 0.779 |
| R-HSA-4641258 | Degradation of DVL | 1.785975e-01 | 0.748 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.238815e-01 | 0.907 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.481064e-01 | 0.829 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.601768e-01 | 0.795 |
| R-HSA-5689603 | UCH proteinases | 1.809788e-01 | 0.742 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.238538e-01 | 0.907 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.890871e-02 | 1.162 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.238538e-01 | 0.907 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.238538e-01 | 0.907 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.451933e-02 | 1.128 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.556645e-01 | 0.808 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.344226e-01 | 0.630 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 7.591202e-02 | 1.120 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.486025e-01 | 0.828 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.614635e-01 | 0.792 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 1.146240e-01 | 0.941 |
| R-HSA-447038 | NrCAM interactions | 1.146240e-01 | 0.941 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.448995e-01 | 0.839 |
| R-HSA-6806664 | Metabolism of vitamin K | 1.448995e-01 | 0.839 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.883894e-01 | 0.725 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.883894e-01 | 0.725 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 2.023905e-01 | 0.694 |
| R-HSA-166208 | mTORC1-mediated signalling | 8.611357e-02 | 1.065 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.429662e-01 | 0.614 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.429662e-01 | 0.614 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 2.429662e-01 | 0.614 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.724196e-01 | 0.763 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.724196e-01 | 0.763 |
| R-HSA-4641257 | Degradation of AXIN | 1.785975e-01 | 0.748 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.785975e-01 | 0.748 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.200911e-01 | 0.920 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.036154e-01 | 0.691 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.298392e-01 | 0.887 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.026377e-01 | 0.693 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.026377e-01 | 0.693 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.133875e-01 | 0.671 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.133875e-01 | 0.671 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.628246e-02 | 1.118 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.354314e-01 | 0.868 |
| R-HSA-162587 | HIV Life Cycle | 1.911029e-01 | 0.719 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.289901e-01 | 0.640 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.541184e-01 | 0.812 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.785975e-01 | 0.748 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.848191e-02 | 1.105 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.238815e-01 | 0.907 |
| R-HSA-73927 | Depurination | 1.848089e-01 | 0.733 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.440977e-01 | 0.841 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.298930e-01 | 0.886 |
| R-HSA-447041 | CHL1 interactions | 1.596482e-01 | 0.797 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.161509e-01 | 0.665 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.161509e-01 | 0.665 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 2.161509e-01 | 0.665 |
| R-HSA-2161522 | Abacavir ADME | 1.076287e-01 | 0.968 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.421444e-01 | 0.847 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.541184e-01 | 0.812 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.601768e-01 | 0.795 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.601768e-01 | 0.795 |
| R-HSA-169911 | Regulation of Apoptosis | 1.662783e-01 | 0.779 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.848089e-01 | 0.733 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.238815e-01 | 0.907 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.180693e-02 | 1.209 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.417604e-01 | 0.617 |
| R-HSA-69242 | S Phase | 7.188239e-02 | 1.143 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.615405e-02 | 1.179 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.615405e-02 | 1.179 |
| R-HSA-9663891 | Selective autophagy | 2.390042e-01 | 0.622 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.179900e-01 | 0.928 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.883894e-01 | 0.725 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 7.096744e-02 | 1.149 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.429662e-01 | 0.614 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.910510e-01 | 0.719 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.973208e-01 | 0.705 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.036154e-01 | 0.691 |
| R-HSA-4086400 | PCP/CE pathway | 1.896529e-01 | 0.722 |
| R-HSA-9707616 | Heme signaling | 1.238815e-01 | 0.907 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.253086e-01 | 0.647 |
| R-HSA-450294 | MAP kinase activation | 1.200911e-01 | 0.920 |
| R-HSA-1632852 | Macroautophagy | 1.432698e-01 | 0.844 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.362358e-01 | 0.866 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 9.144523e-02 | 1.039 |
| R-HSA-9675135 | Diseases of DNA repair | 2.417604e-01 | 0.617 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.298930e-01 | 0.886 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.596482e-01 | 0.797 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.023905e-01 | 0.694 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 1.188686e-01 | 0.925 |
| R-HSA-3371511 | HSF1 activation | 1.724196e-01 | 0.763 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.910510e-01 | 0.719 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.910510e-01 | 0.719 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.226221e-01 | 0.652 |
| R-HSA-448424 | Interleukin-17 signaling | 1.556645e-01 | 0.808 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.289901e-01 | 0.640 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.353703e-01 | 0.628 |
| R-HSA-73887 | Death Receptor Signaling | 1.822726e-01 | 0.739 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.036154e-01 | 0.691 |
| R-HSA-196757 | Metabolism of folate and pterines | 1.785975e-01 | 0.748 |
| R-HSA-9612973 | Autophagy | 1.881425e-01 | 0.726 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.353703e-01 | 0.628 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.766834e-01 | 0.753 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.359427e-01 | 0.867 |
| R-HSA-9824446 | Viral Infection Pathways | 2.023532e-01 | 0.694 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 8.554770e-02 | 1.068 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.429662e-01 | 0.614 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.421444e-01 | 0.847 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.973208e-01 | 0.705 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.036154e-01 | 0.691 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.353703e-01 | 0.628 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.315904e-01 | 0.881 |
| R-HSA-5688426 | Deubiquitination | 2.051762e-01 | 0.688 |
| R-HSA-168256 | Immune System | 2.160054e-01 | 0.666 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.741433e-01 | 0.759 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 1.132121e-01 | 0.946 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.809696e-01 | 0.742 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.351605e-02 | 1.134 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.277150e-01 | 0.894 |
| R-HSA-913531 | Interferon Signaling | 1.694472e-01 | 0.771 |
| R-HSA-373753 | Nephrin family interactions | 7.096744e-02 | 1.149 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.429662e-01 | 0.614 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.724171e-01 | 0.763 |
| R-HSA-9909396 | Circadian clock | 1.179261e-01 | 0.928 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.964146e-01 | 0.707 |
| R-HSA-6807070 | PTEN Regulation | 1.380224e-01 | 0.860 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.683279e-02 | 1.175 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.724196e-01 | 0.763 |
| R-HSA-69541 | Stabilization of p53 | 1.910510e-01 | 0.719 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.910510e-01 | 0.719 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.910510e-01 | 0.719 |
| R-HSA-449147 | Signaling by Interleukins | 1.010780e-01 | 0.995 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.973208e-01 | 0.705 |
| R-HSA-9679506 | SARS-CoV Infections | 2.064475e-01 | 0.685 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.910510e-01 | 0.719 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.007242e-01 | 0.997 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.421444e-01 | 0.847 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.266907e-02 | 1.033 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.162687e-01 | 0.665 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.207782e-01 | 0.656 |
| R-HSA-73928 | Depyrimidination | 2.162687e-01 | 0.665 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.601768e-01 | 0.795 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.438546e-01 | 0.842 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.380224e-01 | 0.860 |
| R-HSA-977225 | Amyloid fiber formation | 7.122038e-02 | 1.147 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.061309e-02 | 1.043 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.436011e-01 | 0.613 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.437225e-01 | 0.613 |
| R-HSA-437239 | Recycling pathway of L1 | 2.481582e-01 | 0.605 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.481582e-01 | 0.605 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.482123e-01 | 0.605 |
| R-HSA-202424 | Downstream TCR signaling | 2.482123e-01 | 0.605 |
| R-HSA-73884 | Base Excision Repair | 2.482123e-01 | 0.605 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.501588e-01 | 0.602 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.501588e-01 | 0.602 |
| R-HSA-168249 | Innate Immune System | 2.515021e-01 | 0.599 |
| R-HSA-9675108 | Nervous system development | 2.534733e-01 | 0.596 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.545614e-01 | 0.594 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.545614e-01 | 0.594 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.560290e-01 | 0.592 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 2.560290e-01 | 0.592 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.560290e-01 | 0.592 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.560290e-01 | 0.592 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.609681e-01 | 0.583 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.609681e-01 | 0.583 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.609681e-01 | 0.583 |
| R-HSA-391251 | Protein folding | 2.621223e-01 | 0.581 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.621223e-01 | 0.581 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.673762e-01 | 0.573 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.688672e-01 | 0.570 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.688672e-01 | 0.570 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.688672e-01 | 0.570 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.688672e-01 | 0.570 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.688672e-01 | 0.570 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.688672e-01 | 0.570 |
| R-HSA-5578768 | Physiological factors | 2.688672e-01 | 0.570 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.688672e-01 | 0.570 |
| R-HSA-9793528 | Ciprofloxacin ADME | 2.688672e-01 | 0.570 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.737837e-01 | 0.563 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.737837e-01 | 0.563 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.761286e-01 | 0.559 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.768332e-01 | 0.558 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.768332e-01 | 0.558 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.801888e-01 | 0.553 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.801888e-01 | 0.553 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.801888e-01 | 0.553 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.808147e-01 | 0.552 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.814847e-01 | 0.551 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 2.814847e-01 | 0.551 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.814847e-01 | 0.551 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.814847e-01 | 0.551 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.814847e-01 | 0.551 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.814847e-01 | 0.551 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.814847e-01 | 0.551 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.814847e-01 | 0.551 |
| R-HSA-379401 | Dopamine clearance from the synaptic cleft | 2.814847e-01 | 0.551 |
| R-HSA-174362 | Transport and metabolism of PAPS | 2.814847e-01 | 0.551 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.814847e-01 | 0.551 |
| R-HSA-73942 | DNA Damage Reversal | 2.814847e-01 | 0.551 |
| R-HSA-422475 | Axon guidance | 2.830143e-01 | 0.548 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.845113e-01 | 0.546 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.865897e-01 | 0.543 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.865897e-01 | 0.543 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.902079e-01 | 0.537 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.929846e-01 | 0.533 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.929846e-01 | 0.533 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 2.929846e-01 | 0.533 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.938852e-01 | 0.532 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.938852e-01 | 0.532 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.938852e-01 | 0.532 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.938852e-01 | 0.532 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 2.938852e-01 | 0.532 |
| R-HSA-70350 | Fructose catabolism | 2.938852e-01 | 0.532 |
| R-HSA-382551 | Transport of small molecules | 2.944821e-01 | 0.531 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.993718e-01 | 0.524 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.993718e-01 | 0.524 |
| R-HSA-9753281 | Paracetamol ADME | 2.993718e-01 | 0.524 |
| R-HSA-70171 | Glycolysis | 3.043382e-01 | 0.517 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.043382e-01 | 0.517 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.057497e-01 | 0.515 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.060724e-01 | 0.514 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 3.060724e-01 | 0.514 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.060724e-01 | 0.514 |
| R-HSA-9927020 | Heme assimilation | 3.060724e-01 | 0.514 |
| R-HSA-5661270 | Formation of xylulose-5-phosphate | 3.060724e-01 | 0.514 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.060724e-01 | 0.514 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.060724e-01 | 0.514 |
| R-HSA-1280218 | Adaptive Immune System | 3.103865e-01 | 0.508 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.121168e-01 | 0.506 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.180500e-01 | 0.498 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.180500e-01 | 0.498 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.180500e-01 | 0.498 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.180500e-01 | 0.498 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.180500e-01 | 0.498 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.180500e-01 | 0.498 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 3.180500e-01 | 0.498 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.180500e-01 | 0.498 |
| R-HSA-2028269 | Signaling by Hippo | 3.180500e-01 | 0.498 |
| R-HSA-9609690 | HCMV Early Events | 3.198673e-01 | 0.495 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.210817e-01 | 0.493 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.232212e-01 | 0.491 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.232212e-01 | 0.491 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.233009e-01 | 0.490 |
| R-HSA-212436 | Generic Transcription Pathway | 3.248104e-01 | 0.488 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.248122e-01 | 0.488 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.248122e-01 | 0.488 |
| R-HSA-186712 | Regulation of beta-cell development | 3.248122e-01 | 0.488 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.298216e-01 | 0.482 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 3.298216e-01 | 0.482 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.298216e-01 | 0.482 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 3.298216e-01 | 0.482 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.298216e-01 | 0.482 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.298216e-01 | 0.482 |
| R-HSA-5358508 | Mismatch Repair | 3.298216e-01 | 0.482 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 3.298216e-01 | 0.482 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.298216e-01 | 0.482 |
| R-HSA-3928664 | Ephrin signaling | 3.298216e-01 | 0.482 |
| R-HSA-9758941 | Gastrulation | 3.311135e-01 | 0.480 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.311300e-01 | 0.480 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.311377e-01 | 0.480 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.311377e-01 | 0.480 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.311377e-01 | 0.480 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.311377e-01 | 0.480 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.311377e-01 | 0.480 |
| R-HSA-156590 | Glutathione conjugation | 3.311377e-01 | 0.480 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.311377e-01 | 0.480 |
| R-HSA-351202 | Metabolism of polyamines | 3.311377e-01 | 0.480 |
| R-HSA-418346 | Platelet homeostasis | 3.373894e-01 | 0.472 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.374467e-01 | 0.472 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.374467e-01 | 0.472 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.413907e-01 | 0.467 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.413907e-01 | 0.467 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.413907e-01 | 0.467 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 3.413907e-01 | 0.467 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.413907e-01 | 0.467 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.413907e-01 | 0.467 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.413907e-01 | 0.467 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.413907e-01 | 0.467 |
| R-HSA-392517 | Rap1 signalling | 3.413907e-01 | 0.467 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.413907e-01 | 0.467 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.428502e-01 | 0.465 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.436706e-01 | 0.464 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.437376e-01 | 0.464 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.468270e-01 | 0.460 |
| R-HSA-162582 | Signal Transduction | 3.474240e-01 | 0.459 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.500095e-01 | 0.456 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.527608e-01 | 0.453 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.527608e-01 | 0.453 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.527608e-01 | 0.453 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.527608e-01 | 0.453 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.527608e-01 | 0.453 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.527608e-01 | 0.453 |
| R-HSA-71288 | Creatine metabolism | 3.527608e-01 | 0.453 |
| R-HSA-445144 | Signal transduction by L1 | 3.527608e-01 | 0.453 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.545984e-01 | 0.450 |
| R-HSA-202403 | TCR signaling | 3.562522e-01 | 0.448 |
| R-HSA-9610379 | HCMV Late Events | 3.624315e-01 | 0.441 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.639353e-01 | 0.439 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.639353e-01 | 0.439 |
| R-HSA-202040 | G-protein activation | 3.639353e-01 | 0.439 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.639353e-01 | 0.439 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.639353e-01 | 0.439 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.639353e-01 | 0.439 |
| R-HSA-198753 | ERK/MAPK targets | 3.639353e-01 | 0.439 |
| R-HSA-2161541 | Abacavir metabolism | 3.639353e-01 | 0.439 |
| R-HSA-210991 | Basigin interactions | 3.639353e-01 | 0.439 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.656596e-01 | 0.437 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.656596e-01 | 0.437 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.700208e-01 | 0.432 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.748815e-01 | 0.426 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 3.748815e-01 | 0.426 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.749176e-01 | 0.426 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.749176e-01 | 0.426 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.749176e-01 | 0.426 |
| R-HSA-9755088 | Ribavirin ADME | 3.749176e-01 | 0.426 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.749176e-01 | 0.426 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 3.749176e-01 | 0.426 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.749176e-01 | 0.426 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.750444e-01 | 0.426 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.810402e-01 | 0.419 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.857109e-01 | 0.414 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.857109e-01 | 0.414 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.857109e-01 | 0.414 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.857109e-01 | 0.414 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 3.857109e-01 | 0.414 |
| R-HSA-8964038 | LDL clearance | 3.857109e-01 | 0.414 |
| R-HSA-5652084 | Fructose metabolism | 3.857109e-01 | 0.414 |
| R-HSA-71384 | Ethanol oxidation | 3.857109e-01 | 0.414 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.857109e-01 | 0.414 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.857109e-01 | 0.414 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.857109e-01 | 0.414 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.890688e-01 | 0.410 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.932796e-01 | 0.405 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.963185e-01 | 0.402 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.963185e-01 | 0.402 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.963185e-01 | 0.402 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.963185e-01 | 0.402 |
| R-HSA-3000170 | Syndecan interactions | 3.963185e-01 | 0.402 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.963185e-01 | 0.402 |
| R-HSA-70326 | Glucose metabolism | 3.983764e-01 | 0.400 |
| R-HSA-5619102 | SLC transporter disorders | 4.014934e-01 | 0.396 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.038765e-01 | 0.394 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.054087e-01 | 0.392 |
| R-HSA-429947 | Deadenylation of mRNA | 4.067435e-01 | 0.391 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.067435e-01 | 0.391 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 4.067435e-01 | 0.391 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.067435e-01 | 0.391 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 4.067435e-01 | 0.391 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.067435e-01 | 0.391 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.076456e-01 | 0.390 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 4.169892e-01 | 0.380 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 4.169892e-01 | 0.380 |
| R-HSA-1296059 | G protein gated Potassium channels | 4.169892e-01 | 0.380 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.169892e-01 | 0.380 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.169892e-01 | 0.380 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.169892e-01 | 0.380 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.169892e-01 | 0.380 |
| R-HSA-389599 | Alpha-oxidation of phytanate | 4.169892e-01 | 0.380 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 4.169892e-01 | 0.380 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.169892e-01 | 0.380 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.170158e-01 | 0.380 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.208830e-01 | 0.376 |
| R-HSA-917937 | Iron uptake and transport | 4.233809e-01 | 0.373 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.236444e-01 | 0.373 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.270585e-01 | 0.370 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 4.270585e-01 | 0.370 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.270585e-01 | 0.370 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.270585e-01 | 0.370 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.270585e-01 | 0.370 |
| R-HSA-3295583 | TRP channels | 4.270585e-01 | 0.370 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.270585e-01 | 0.370 |
| R-HSA-5663205 | Infectious disease | 4.337801e-01 | 0.363 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.369545e-01 | 0.360 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.369545e-01 | 0.360 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.369545e-01 | 0.360 |
| R-HSA-8949613 | Cristae formation | 4.369545e-01 | 0.360 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.369545e-01 | 0.360 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.369545e-01 | 0.360 |
| R-HSA-194138 | Signaling by VEGF | 4.397262e-01 | 0.357 |
| R-HSA-5619084 | ABC transporter disorders | 4.410695e-01 | 0.355 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 4.417013e-01 | 0.355 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.466802e-01 | 0.350 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.466802e-01 | 0.350 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 4.466802e-01 | 0.350 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.468995e-01 | 0.350 |
| R-HSA-114608 | Platelet degranulation | 4.487735e-01 | 0.348 |
| R-HSA-168255 | Influenza Infection | 4.515785e-01 | 0.345 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.526955e-01 | 0.344 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.562385e-01 | 0.341 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.562385e-01 | 0.341 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.562385e-01 | 0.341 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.562385e-01 | 0.341 |
| R-HSA-180024 | DARPP-32 events | 4.562385e-01 | 0.341 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.562385e-01 | 0.341 |
| R-HSA-8939211 | ESR-mediated signaling | 4.626686e-01 | 0.335 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.656323e-01 | 0.332 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.656323e-01 | 0.332 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.656323e-01 | 0.332 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.656323e-01 | 0.332 |
| R-HSA-112311 | Neurotransmitter clearance | 4.656323e-01 | 0.332 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.656323e-01 | 0.332 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.656323e-01 | 0.332 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.679846e-01 | 0.330 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.698734e-01 | 0.328 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.748643e-01 | 0.323 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.748643e-01 | 0.323 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 4.755278e-01 | 0.323 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.755493e-01 | 0.323 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.799545e-01 | 0.319 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.839374e-01 | 0.315 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.854650e-01 | 0.314 |
| R-HSA-73894 | DNA Repair | 4.914573e-01 | 0.309 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.922695e-01 | 0.308 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.922695e-01 | 0.308 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.928543e-01 | 0.307 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.928543e-01 | 0.307 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.928543e-01 | 0.307 |
| R-HSA-354192 | Integrin signaling | 4.928543e-01 | 0.307 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.016177e-01 | 0.300 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.016177e-01 | 0.300 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 5.016177e-01 | 0.300 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.016177e-01 | 0.300 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.016177e-01 | 0.300 |
| R-HSA-189483 | Heme degradation | 5.016177e-01 | 0.300 |
| R-HSA-156902 | Peptide chain elongation | 5.032424e-01 | 0.298 |
| R-HSA-9609646 | HCMV Infection | 5.055123e-01 | 0.296 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.102302e-01 | 0.292 |
| R-HSA-392518 | Signal amplification | 5.102302e-01 | 0.292 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.102302e-01 | 0.292 |
| R-HSA-5673000 | RAF activation | 5.102302e-01 | 0.292 |
| R-HSA-5365859 | RA biosynthesis pathway | 5.102302e-01 | 0.292 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.186943e-01 | 0.285 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.186943e-01 | 0.285 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.194127e-01 | 0.284 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.194127e-01 | 0.284 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.247245e-01 | 0.280 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.247245e-01 | 0.280 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.270127e-01 | 0.278 |
| R-HSA-9845576 | Glycosphingolipid transport | 5.270127e-01 | 0.278 |
| R-HSA-163560 | Triglyceride catabolism | 5.270127e-01 | 0.278 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.272019e-01 | 0.278 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.292779e-01 | 0.276 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.299968e-01 | 0.276 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.299968e-01 | 0.276 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.313798e-01 | 0.275 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.351879e-01 | 0.271 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 5.351879e-01 | 0.271 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.351879e-01 | 0.271 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.351879e-01 | 0.271 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.364050e-01 | 0.271 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.399483e-01 | 0.268 |
| R-HSA-1266738 | Developmental Biology | 5.432168e-01 | 0.265 |
| R-HSA-74217 | Purine salvage | 5.432222e-01 | 0.265 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 5.432222e-01 | 0.265 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.432222e-01 | 0.265 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.432222e-01 | 0.265 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.455743e-01 | 0.263 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.506864e-01 | 0.259 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.506864e-01 | 0.259 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.511182e-01 | 0.259 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.511182e-01 | 0.259 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.511182e-01 | 0.259 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 5.511182e-01 | 0.259 |
| R-HSA-71336 | Pentose phosphate pathway | 5.511182e-01 | 0.259 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.511182e-01 | 0.259 |
| R-HSA-1296071 | Potassium Channels | 5.557581e-01 | 0.255 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.588781e-01 | 0.253 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.588781e-01 | 0.253 |
| R-HSA-3371568 | Attenuation phase | 5.588781e-01 | 0.253 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.588781e-01 | 0.253 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.588781e-01 | 0.253 |
| R-HSA-167169 | HIV Transcription Elongation | 5.588781e-01 | 0.253 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.588781e-01 | 0.253 |
| R-HSA-5260271 | Diseases of Immune System | 5.588781e-01 | 0.253 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.588781e-01 | 0.253 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.665043e-01 | 0.247 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.665043e-01 | 0.247 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.739992e-01 | 0.241 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.739992e-01 | 0.241 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.739992e-01 | 0.241 |
| R-HSA-189451 | Heme biosynthesis | 5.739992e-01 | 0.241 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.805057e-01 | 0.236 |
| R-HSA-991365 | Activation of GABAB receptors | 5.813650e-01 | 0.236 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.813650e-01 | 0.236 |
| R-HSA-977444 | GABA B receptor activation | 5.813650e-01 | 0.236 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.813650e-01 | 0.236 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.813650e-01 | 0.236 |
| R-HSA-1483255 | PI Metabolism | 5.853325e-01 | 0.233 |
| R-HSA-8854214 | TBC/RABGAPs | 5.886038e-01 | 0.230 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.886038e-01 | 0.230 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.886038e-01 | 0.230 |
| R-HSA-192823 | Viral mRNA Translation | 5.901183e-01 | 0.229 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.914621e-01 | 0.228 |
| R-HSA-111885 | Opioid Signalling | 5.948631e-01 | 0.226 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.957179e-01 | 0.225 |
| R-HSA-373752 | Netrin-1 signaling | 5.957179e-01 | 0.225 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.990900e-01 | 0.223 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.026301e-01 | 0.220 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.027094e-01 | 0.220 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.027094e-01 | 0.220 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.027094e-01 | 0.220 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.027094e-01 | 0.220 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.043937e-01 | 0.219 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.134315e-01 | 0.212 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.134315e-01 | 0.212 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.134315e-01 | 0.212 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.163331e-01 | 0.210 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.163331e-01 | 0.210 |
| R-HSA-1483191 | Synthesis of PC | 6.163331e-01 | 0.210 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 6.163331e-01 | 0.210 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.179710e-01 | 0.209 |
| R-HSA-9634597 | GPER1 signaling | 6.229693e-01 | 0.206 |
| R-HSA-70263 | Gluconeogenesis | 6.229693e-01 | 0.206 |
| R-HSA-73893 | DNA Damage Bypass | 6.294912e-01 | 0.201 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.357204e-01 | 0.197 |
| R-HSA-72312 | rRNA processing | 6.392808e-01 | 0.194 |
| R-HSA-72306 | tRNA processing | 6.393571e-01 | 0.194 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.439576e-01 | 0.191 |
| R-HSA-109582 | Hemostasis | 6.463521e-01 | 0.190 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.483899e-01 | 0.188 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.528195e-01 | 0.185 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.544735e-01 | 0.184 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.565289e-01 | 0.183 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.652212e-01 | 0.177 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.652212e-01 | 0.177 |
| R-HSA-418597 | G alpha (z) signalling events | 6.663279e-01 | 0.176 |
| R-HSA-72766 | Translation | 6.680405e-01 | 0.175 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.721022e-01 | 0.173 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.721022e-01 | 0.173 |
| R-HSA-177929 | Signaling by EGFR | 6.721022e-01 | 0.173 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.721022e-01 | 0.173 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.833539e-01 | 0.165 |
| R-HSA-180786 | Extension of Telomeres | 6.888346e-01 | 0.162 |
| R-HSA-8979227 | Triglyceride metabolism | 6.888346e-01 | 0.162 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.927727e-01 | 0.159 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.942208e-01 | 0.159 |
| R-HSA-977443 | GABA receptor activation | 6.942208e-01 | 0.159 |
| R-HSA-983189 | Kinesins | 6.942208e-01 | 0.159 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.942208e-01 | 0.159 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.942208e-01 | 0.159 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 6.942208e-01 | 0.159 |
| R-HSA-379724 | tRNA Aminoacylation | 6.942208e-01 | 0.159 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.995140e-01 | 0.155 |
| R-HSA-1442490 | Collagen degradation | 6.995140e-01 | 0.155 |
| R-HSA-8956321 | Nucleotide salvage | 6.995140e-01 | 0.155 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.047160e-01 | 0.152 |
| R-HSA-1268020 | Mitochondrial protein import | 7.047160e-01 | 0.152 |
| R-HSA-5617833 | Cilium Assembly | 7.051067e-01 | 0.152 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.057088e-01 | 0.151 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.057951e-01 | 0.151 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.112902e-01 | 0.148 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.231247e-01 | 0.141 |
| R-HSA-199991 | Membrane Trafficking | 7.293737e-01 | 0.137 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 7.294102e-01 | 0.137 |
| R-HSA-167172 | Transcription of the HIV genome | 7.340963e-01 | 0.134 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.340963e-01 | 0.134 |
| R-HSA-1643685 | Disease | 7.375018e-01 | 0.132 |
| R-HSA-163685 | Integration of energy metabolism | 7.455320e-01 | 0.128 |
| R-HSA-9638482 | Metal ion assimilation from the host | 7.476751e-01 | 0.126 |
| R-HSA-189445 | Metabolism of porphyrins | 7.476751e-01 | 0.126 |
| R-HSA-8978934 | Metabolism of cofactors | 7.476751e-01 | 0.126 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.487579e-01 | 0.126 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.520460e-01 | 0.124 |
| R-HSA-74259 | Purine catabolism | 7.520460e-01 | 0.124 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.520460e-01 | 0.124 |
| R-HSA-4086398 | Ca2+ pathway | 7.563415e-01 | 0.121 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.563415e-01 | 0.121 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 7.563415e-01 | 0.121 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.582262e-01 | 0.120 |
| R-HSA-9664407 | Parasite infection | 7.582262e-01 | 0.120 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.582262e-01 | 0.120 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.605628e-01 | 0.119 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.613132e-01 | 0.118 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.647112e-01 | 0.117 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.647112e-01 | 0.117 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.659715e-01 | 0.116 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.727944e-01 | 0.112 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.767317e-01 | 0.110 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.767317e-01 | 0.110 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.767317e-01 | 0.110 |
| R-HSA-9659379 | Sensory processing of sound | 7.806009e-01 | 0.108 |
| R-HSA-9748784 | Drug ADME | 7.836477e-01 | 0.106 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.844033e-01 | 0.105 |
| R-HSA-6806834 | Signaling by MET | 7.844033e-01 | 0.105 |
| R-HSA-166520 | Signaling by NTRKs | 7.848038e-01 | 0.105 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.862318e-01 | 0.104 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.881401e-01 | 0.103 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 7.881401e-01 | 0.103 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.903509e-01 | 0.102 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.903509e-01 | 0.102 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.954211e-01 | 0.099 |
| R-HSA-1483257 | Phospholipid metabolism | 7.985041e-01 | 0.098 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.989676e-01 | 0.097 |
| R-HSA-1989781 | PPARA activates gene expression | 8.036717e-01 | 0.095 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.087868e-01 | 0.092 |
| R-HSA-877300 | Interferon gamma signaling | 8.137832e-01 | 0.089 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.221352e-01 | 0.085 |
| R-HSA-15869 | Metabolism of nucleotides | 8.231384e-01 | 0.085 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.257687e-01 | 0.083 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.312309e-01 | 0.080 |
| R-HSA-2168880 | Scavenging of heme from plasma | 8.426414e-01 | 0.074 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.453718e-01 | 0.073 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.497322e-01 | 0.071 |
| R-HSA-422356 | Regulation of insulin secretion | 8.506918e-01 | 0.070 |
| R-HSA-190236 | Signaling by FGFR | 8.506918e-01 | 0.070 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.532830e-01 | 0.069 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.532830e-01 | 0.069 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.569914e-01 | 0.067 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.583318e-01 | 0.066 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.655821e-01 | 0.063 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.702091e-01 | 0.060 |
| R-HSA-416476 | G alpha (q) signalling events | 8.723203e-01 | 0.059 |
| R-HSA-983712 | Ion channel transport | 8.775920e-01 | 0.057 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.810938e-01 | 0.055 |
| R-HSA-9658195 | Leishmania infection | 8.959238e-01 | 0.048 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.959238e-01 | 0.048 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.984447e-01 | 0.047 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.992280e-01 | 0.046 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.002096e-01 | 0.046 |
| R-HSA-6805567 | Keratinization | 9.047240e-01 | 0.043 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.053230e-01 | 0.043 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.085859e-01 | 0.042 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.124465e-01 | 0.040 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.136753e-01 | 0.039 |
| R-HSA-8956319 | Nucleotide catabolism | 9.191487e-01 | 0.037 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.205549e-01 | 0.036 |
| R-HSA-8951664 | Neddylation | 9.229401e-01 | 0.035 |
| R-HSA-9843745 | Adipogenesis | 9.232946e-01 | 0.035 |
| R-HSA-5576891 | Cardiac conduction | 9.232946e-01 | 0.035 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.246290e-01 | 0.034 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.280993e-01 | 0.032 |
| R-HSA-392499 | Metabolism of proteins | 9.314415e-01 | 0.031 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.322435e-01 | 0.030 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.383404e-01 | 0.028 |
| R-HSA-8957322 | Metabolism of steroids | 9.391220e-01 | 0.027 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.404801e-01 | 0.027 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.469510e-01 | 0.024 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.505042e-01 | 0.022 |
| R-HSA-597592 | Post-translational protein modification | 9.609478e-01 | 0.017 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.638144e-01 | 0.016 |
| R-HSA-418555 | G alpha (s) signalling events | 9.639691e-01 | 0.016 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.652151e-01 | 0.015 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.652151e-01 | 0.015 |
| R-HSA-611105 | Respiratory electron transport | 9.681454e-01 | 0.014 |
| R-HSA-112316 | Neuronal System | 9.716742e-01 | 0.012 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.755408e-01 | 0.011 |
| R-HSA-428157 | Sphingolipid metabolism | 9.787574e-01 | 0.009 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.794933e-01 | 0.009 |
| R-HSA-8978868 | Fatty acid metabolism | 9.799869e-01 | 0.009 |
| R-HSA-397014 | Muscle contraction | 9.828091e-01 | 0.008 |
| R-HSA-1474244 | Extracellular matrix organization | 9.848718e-01 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.873018e-01 | 0.006 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.889439e-01 | 0.005 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.946475e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.954187e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.961237e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.966595e-01 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.982507e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.995623e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998411e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998720e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999799e-01 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 9.999920e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.999978e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MOS |
0.716 | 0.074 | 1 | 0.876 |
BMPR1B |
0.710 | 0.093 | 1 | 0.815 |
CDC7 |
0.710 | 0.048 | 1 | 0.862 |
CLK3 |
0.709 | 0.045 | 1 | 0.887 |
DSTYK |
0.708 | 0.091 | 2 | 0.846 |
COT |
0.707 | -0.034 | 2 | 0.832 |
TGFBR1 |
0.707 | 0.099 | -2 | 0.723 |
PRPK |
0.705 | -0.006 | -1 | 0.814 |
ATR |
0.704 | 0.026 | 1 | 0.801 |
NLK |
0.704 | 0.134 | 1 | 0.870 |
CDK8 |
0.704 | 0.145 | 1 | 0.769 |
MTOR |
0.703 | 0.040 | 1 | 0.796 |
BMPR2 |
0.703 | -0.052 | -2 | 0.708 |
ULK1 |
0.703 | 0.394 | -3 | 0.375 |
PDHK4 |
0.702 | -0.031 | 1 | 0.823 |
KIS |
0.702 | 0.117 | 1 | 0.785 |
ACVR2B |
0.702 | 0.054 | -2 | 0.708 |
CK1D |
0.702 | -0.018 | -3 | 0.028 |
CDKL1 |
0.701 | -0.032 | -3 | 0.088 |
ALK2 |
0.701 | 0.085 | -2 | 0.719 |
ALK4 |
0.701 | 0.060 | -2 | 0.727 |
JNK3 |
0.701 | 0.131 | 1 | 0.768 |
LATS1 |
0.700 | -0.019 | -3 | 0.073 |
HIPK4 |
0.700 | 0.063 | 1 | 0.811 |
GRK1 |
0.700 | 0.040 | -2 | 0.695 |
CAMK2G |
0.699 | 0.011 | 2 | 0.795 |
JNK2 |
0.699 | 0.127 | 1 | 0.741 |
CK1E |
0.698 | -0.015 | -3 | 0.030 |
CDK19 |
0.698 | 0.139 | 1 | 0.740 |
BMPR1A |
0.698 | 0.078 | 1 | 0.795 |
GRK7 |
0.698 | 0.021 | 1 | 0.766 |
RAF1 |
0.698 | -0.024 | 1 | 0.801 |
ICK |
0.697 | 0.007 | -3 | 0.107 |
ERK5 |
0.697 | 0.048 | 1 | 0.838 |
ULK2 |
0.697 | 0.260 | 2 | 0.746 |
CAMK1B |
0.696 | -0.078 | -3 | 0.101 |
ATM |
0.696 | 0.045 | 1 | 0.742 |
DYRK2 |
0.695 | 0.078 | 1 | 0.766 |
GRK5 |
0.695 | -0.073 | -3 | 0.095 |
PIM3 |
0.695 | -0.076 | -3 | 0.068 |
ACVR2A |
0.695 | 0.031 | -2 | 0.692 |
DAPK2 |
0.695 | -0.047 | -3 | 0.111 |
PRKD1 |
0.694 | -0.019 | -3 | 0.103 |
SKMLCK |
0.694 | -0.047 | -2 | 0.684 |
CDKL5 |
0.694 | -0.018 | -3 | 0.088 |
NDR2 |
0.693 | -0.065 | -3 | 0.068 |
PDHK1 |
0.693 | -0.045 | 1 | 0.793 |
NEK7 |
0.693 | 0.023 | -3 | 0.176 |
SRPK1 |
0.692 | -0.008 | -3 | 0.056 |
PKN3 |
0.692 | 0.002 | -3 | 0.167 |
GRK6 |
0.692 | -0.023 | 1 | 0.815 |
NEK6 |
0.692 | 0.007 | -2 | 0.702 |
CK1A2 |
0.691 | -0.036 | -3 | 0.026 |
NEK9 |
0.691 | 0.157 | 2 | 0.783 |
NUAK2 |
0.691 | -0.038 | -3 | 0.111 |
CLK4 |
0.691 | 0.008 | -3 | 0.074 |
CAMLCK |
0.691 | -0.070 | -2 | 0.635 |
MARK4 |
0.691 | 0.005 | 4 | 0.853 |
TGFBR2 |
0.690 | -0.012 | -2 | 0.705 |
SRPK2 |
0.690 | -0.012 | -3 | 0.056 |
IKKA |
0.690 | -0.038 | -2 | 0.584 |
HUNK |
0.690 | 0.021 | 2 | 0.783 |
SRPK3 |
0.690 | -0.017 | -3 | 0.069 |
NIK |
0.690 | -0.126 | -3 | 0.107 |
CLK2 |
0.690 | 0.041 | -3 | 0.053 |
PLK1 |
0.690 | 0.041 | -2 | 0.654 |
LATS2 |
0.689 | -0.070 | -5 | 0.500 |
CLK1 |
0.689 | 0.024 | -3 | 0.071 |
GRK4 |
0.689 | -0.036 | -2 | 0.724 |
P38A |
0.689 | 0.101 | 1 | 0.796 |
PRP4 |
0.689 | -0.000 | -3 | 0.072 |
CAMK2D |
0.689 | -0.035 | -3 | 0.116 |
P38B |
0.689 | 0.104 | 1 | 0.747 |
PIM1 |
0.688 | -0.067 | -3 | 0.059 |
MASTL |
0.688 | -0.088 | -2 | 0.628 |
HIPK1 |
0.687 | 0.058 | 1 | 0.781 |
CHK1 |
0.687 | -0.062 | -3 | 0.103 |
IKKB |
0.687 | -0.087 | -2 | 0.565 |
BRAF |
0.687 | 0.033 | -4 | 0.500 |
MAPKAPK3 |
0.687 | -0.075 | -3 | 0.084 |
GRK2 |
0.686 | -0.019 | -2 | 0.625 |
TBK1 |
0.686 | -0.066 | 1 | 0.688 |
DYRK1A |
0.686 | 0.039 | 1 | 0.810 |
P38D |
0.686 | 0.118 | 1 | 0.698 |
MAPKAPK2 |
0.686 | -0.053 | -3 | 0.054 |
P38G |
0.685 | 0.098 | 1 | 0.683 |
CDK1 |
0.685 | 0.080 | 1 | 0.759 |
ANKRD3 |
0.685 | -0.064 | 1 | 0.785 |
FAM20C |
0.685 | 0.071 | 2 | 0.656 |
HIPK2 |
0.684 | 0.074 | 1 | 0.706 |
CHAK2 |
0.684 | -0.046 | -1 | 0.803 |
DYRK4 |
0.684 | 0.093 | 1 | 0.727 |
ERK1 |
0.684 | 0.098 | 1 | 0.739 |
CAMK2B |
0.684 | -0.011 | 2 | 0.776 |
CDK7 |
0.684 | 0.071 | 1 | 0.789 |
DYRK1B |
0.684 | 0.063 | 1 | 0.748 |
IKKE |
0.684 | -0.053 | 1 | 0.683 |
CAMK2A |
0.683 | -0.021 | 2 | 0.778 |
AMPKA1 |
0.683 | -0.078 | -3 | 0.096 |
DLK |
0.683 | -0.140 | 1 | 0.783 |
MEK1 |
0.683 | -0.081 | 2 | 0.803 |
GCN2 |
0.683 | -0.067 | 2 | 0.759 |
CDK18 |
0.683 | 0.089 | 1 | 0.733 |
TLK1 |
0.683 | -0.007 | -2 | 0.750 |
DNAPK |
0.683 | 0.043 | 1 | 0.687 |
SMG1 |
0.683 | 0.011 | 1 | 0.751 |
NDR1 |
0.682 | -0.109 | -3 | 0.076 |
PASK |
0.682 | -0.023 | -3 | 0.083 |
WNK1 |
0.682 | -0.069 | -2 | 0.668 |
P70S6KB |
0.682 | -0.092 | -3 | 0.078 |
PRKD2 |
0.682 | -0.064 | -3 | 0.077 |
SBK |
0.681 | -0.042 | -3 | 0.041 |
RSK2 |
0.681 | -0.083 | -3 | 0.056 |
HIPK3 |
0.681 | 0.063 | 1 | 0.767 |
CDK17 |
0.680 | 0.093 | 1 | 0.690 |
CK2A2 |
0.680 | 0.091 | 1 | 0.762 |
JNK1 |
0.680 | 0.100 | 1 | 0.740 |
RIPK3 |
0.680 | -0.061 | 3 | 0.754 |
TSSK2 |
0.680 | -0.077 | -5 | 0.500 |
GAK |
0.680 | 0.040 | 1 | 0.832 |
VRK2 |
0.680 | -0.124 | 1 | 0.824 |
PINK1 |
0.680 | 0.012 | 1 | 0.819 |
P90RSK |
0.680 | -0.084 | -3 | 0.084 |
TLK2 |
0.680 | -0.057 | 1 | 0.733 |
YSK4 |
0.680 | -0.065 | 1 | 0.726 |
GRK3 |
0.679 | -0.022 | -2 | 0.617 |
NEK2 |
0.679 | 0.049 | 2 | 0.762 |
BCKDK |
0.679 | -0.054 | -1 | 0.767 |
LKB1 |
0.679 | 0.046 | -3 | 0.182 |
TSSK1 |
0.679 | -0.063 | -3 | 0.096 |
MLK1 |
0.678 | -0.122 | 2 | 0.751 |
AMPKA2 |
0.678 | -0.085 | -3 | 0.080 |
PLK3 |
0.678 | -0.016 | 2 | 0.757 |
CDK5 |
0.678 | 0.068 | 1 | 0.803 |
NEK5 |
0.677 | 0.032 | 1 | 0.763 |
QSK |
0.677 | -0.025 | 4 | 0.828 |
ERK2 |
0.677 | 0.070 | 1 | 0.776 |
CK1A |
0.677 | -0.028 | -3 | 0.013 |
CDK13 |
0.677 | 0.067 | 1 | 0.766 |
PKR |
0.677 | -0.080 | 1 | 0.772 |
MPSK1 |
0.677 | 0.027 | 1 | 0.751 |
MSK1 |
0.677 | -0.058 | -3 | 0.070 |
WNK3 |
0.676 | -0.092 | 1 | 0.757 |
MST4 |
0.676 | -0.063 | 2 | 0.797 |
MAK |
0.676 | 0.039 | -2 | 0.607 |
MLK2 |
0.676 | -0.124 | 2 | 0.772 |
PRKD3 |
0.676 | -0.084 | -3 | 0.078 |
MARK2 |
0.675 | 0.006 | 4 | 0.762 |
TTBK2 |
0.675 | -0.077 | 2 | 0.664 |
RSK4 |
0.675 | -0.070 | -3 | 0.059 |
NUAK1 |
0.675 | -0.068 | -3 | 0.098 |
MSK2 |
0.675 | -0.084 | -3 | 0.067 |
PIM2 |
0.675 | -0.079 | -3 | 0.072 |
RSK3 |
0.675 | -0.091 | -3 | 0.079 |
RIPK1 |
0.674 | -0.106 | 1 | 0.731 |
SIK |
0.674 | -0.048 | -3 | 0.086 |
PKN2 |
0.674 | -0.100 | -3 | 0.097 |
MEKK3 |
0.674 | -0.087 | 1 | 0.742 |
MYLK4 |
0.674 | -0.072 | -2 | 0.571 |
DYRK3 |
0.674 | 0.014 | 1 | 0.762 |
CAMKK1 |
0.674 | 0.086 | -2 | 0.523 |
CAMK4 |
0.674 | -0.117 | -3 | 0.103 |
SMMLCK |
0.673 | -0.070 | -3 | 0.101 |
AKT2 |
0.673 | -0.070 | -3 | 0.057 |
MAPKAPK5 |
0.673 | -0.063 | -3 | 0.126 |
PKACG |
0.673 | -0.093 | -2 | 0.524 |
HRI |
0.673 | -0.041 | -2 | 0.696 |
MARK3 |
0.672 | -0.003 | 4 | 0.785 |
CDK14 |
0.672 | 0.071 | 1 | 0.763 |
CAMKK2 |
0.672 | 0.026 | -2 | 0.517 |
PERK |
0.672 | -0.065 | -2 | 0.693 |
CDK9 |
0.671 | 0.064 | 1 | 0.767 |
QIK |
0.671 | -0.078 | -3 | 0.113 |
DAPK3 |
0.671 | -0.061 | -3 | 0.072 |
AURC |
0.671 | -0.049 | -2 | 0.460 |
PKACB |
0.671 | -0.070 | -2 | 0.471 |
NIM1 |
0.671 | -0.051 | 3 | 0.778 |
DCAMKL1 |
0.670 | -0.099 | -3 | 0.074 |
CDK2 |
0.670 | 0.033 | 1 | 0.809 |
MEKK1 |
0.670 | -0.069 | 1 | 0.739 |
CDK16 |
0.670 | 0.076 | 1 | 0.708 |
MARK1 |
0.670 | -0.015 | 4 | 0.804 |
NEK11 |
0.670 | -0.006 | 1 | 0.741 |
CDK12 |
0.670 | 0.057 | 1 | 0.740 |
SGK3 |
0.670 | -0.081 | -3 | 0.064 |
MEK5 |
0.669 | -0.151 | 2 | 0.783 |
MST2 |
0.669 | -0.061 | 1 | 0.760 |
CK1G1 |
0.669 | -0.068 | -3 | 0.020 |
PRKX |
0.669 | -0.057 | -3 | 0.030 |
DRAK1 |
0.668 | -0.028 | 1 | 0.748 |
GSK3A |
0.668 | 0.028 | 4 | 0.516 |
CAMK1D |
0.668 | -0.096 | -3 | 0.049 |
CK2A1 |
0.668 | 0.071 | 1 | 0.742 |
BRSK1 |
0.668 | -0.057 | -3 | 0.090 |
DAPK1 |
0.668 | -0.052 | -3 | 0.071 |
CDK3 |
0.668 | 0.071 | 1 | 0.710 |
PLK2 |
0.668 | -0.026 | -3 | 0.108 |
MEKK2 |
0.667 | -0.105 | 2 | 0.753 |
PAK1 |
0.667 | -0.100 | -2 | 0.579 |
PKCD |
0.667 | -0.112 | 2 | 0.723 |
SGK1 |
0.667 | -0.063 | -3 | 0.035 |
MELK |
0.666 | -0.123 | -3 | 0.082 |
MOK |
0.666 | 0.017 | 1 | 0.768 |
AURB |
0.666 | -0.059 | -2 | 0.452 |
GCK |
0.665 | -0.061 | 1 | 0.767 |
MLK3 |
0.665 | -0.095 | 2 | 0.671 |
CAMK1G |
0.665 | -0.084 | -3 | 0.107 |
CDK10 |
0.665 | 0.053 | 1 | 0.752 |
TAK1 |
0.665 | -0.051 | 1 | 0.781 |
NEK8 |
0.664 | -0.037 | 2 | 0.768 |
PAK3 |
0.664 | -0.104 | -2 | 0.567 |
TAO3 |
0.664 | -0.121 | 1 | 0.752 |
MLK4 |
0.663 | -0.113 | 2 | 0.663 |
CHK2 |
0.663 | -0.085 | -3 | 0.052 |
WNK4 |
0.663 | -0.080 | -2 | 0.659 |
AURA |
0.663 | -0.058 | -2 | 0.446 |
MST3 |
0.662 | -0.092 | 2 | 0.781 |
GSK3B |
0.662 | 0.012 | 4 | 0.507 |
PBK |
0.661 | -0.008 | 1 | 0.757 |
CHAK1 |
0.661 | -0.086 | 2 | 0.740 |
ZAK |
0.661 | -0.125 | 1 | 0.711 |
PDK1 |
0.661 | -0.090 | 1 | 0.733 |
PKACA |
0.661 | -0.075 | -2 | 0.424 |
MNK2 |
0.661 | -0.096 | -2 | 0.568 |
P70S6K |
0.661 | -0.098 | -3 | 0.081 |
PAK2 |
0.661 | -0.117 | -2 | 0.556 |
NEK4 |
0.660 | 0.015 | 1 | 0.723 |
PKCB |
0.660 | -0.093 | 2 | 0.666 |
BRSK2 |
0.660 | -0.092 | -3 | 0.095 |
DCAMKL2 |
0.660 | -0.104 | -3 | 0.083 |
PKCA |
0.659 | -0.082 | 2 | 0.657 |
NEK1 |
0.659 | 0.014 | 1 | 0.728 |
CK1G3 |
0.658 | -0.062 | -3 | 0.008 |
HPK1 |
0.658 | -0.055 | 1 | 0.747 |
LRRK2 |
0.658 | -0.101 | 2 | 0.804 |
MINK |
0.657 | -0.059 | 1 | 0.735 |
PKCG |
0.657 | -0.103 | 2 | 0.662 |
CAMK1A |
0.657 | -0.095 | -3 | 0.051 |
EEF2K |
0.657 | -0.062 | 3 | 0.770 |
AKT1 |
0.657 | -0.084 | -3 | 0.055 |
MEK2 |
0.657 | -0.025 | 2 | 0.773 |
TNIK |
0.656 | -0.064 | 3 | 0.814 |
PKCZ |
0.656 | -0.121 | 2 | 0.721 |
PKG2 |
0.656 | -0.100 | -2 | 0.458 |
PLK4 |
0.656 | -0.093 | 2 | 0.614 |
IRE1 |
0.656 | -0.138 | 1 | 0.714 |
MNK1 |
0.656 | -0.111 | -2 | 0.580 |
MRCKA |
0.656 | -0.097 | -3 | 0.065 |
SSTK |
0.655 | -0.069 | 4 | 0.812 |
TAO2 |
0.655 | -0.128 | 2 | 0.795 |
SNRK |
0.655 | -0.105 | 2 | 0.671 |
PHKG1 |
0.655 | -0.133 | -3 | 0.076 |
MEKK6 |
0.655 | -0.094 | 1 | 0.744 |
MAP3K15 |
0.655 | -0.087 | 1 | 0.702 |
ERK7 |
0.654 | 0.007 | 2 | 0.490 |
HGK |
0.654 | -0.077 | 3 | 0.812 |
MST1 |
0.654 | -0.114 | 1 | 0.733 |
PKCH |
0.654 | -0.116 | 2 | 0.651 |
PAK6 |
0.654 | -0.062 | -2 | 0.467 |
ROCK2 |
0.654 | -0.096 | -3 | 0.065 |
IRAK1 |
0.654 | -0.076 | -1 | 0.702 |
CRIK |
0.654 | -0.079 | -3 | 0.059 |
DMPK1 |
0.653 | -0.083 | -3 | 0.056 |
IRE2 |
0.653 | -0.121 | 2 | 0.696 |
ALPHAK3 |
0.653 | -0.021 | -1 | 0.763 |
AKT3 |
0.652 | -0.077 | -3 | 0.039 |
CDK6 |
0.652 | 0.053 | 1 | 0.744 |
BIKE |
0.651 | 0.038 | 1 | 0.725 |
MRCKB |
0.651 | -0.096 | -3 | 0.066 |
TTK |
0.650 | -0.071 | -2 | 0.703 |
KHS1 |
0.649 | -0.072 | 1 | 0.729 |
VRK1 |
0.649 | -0.152 | 2 | 0.798 |
CK1G2 |
0.649 | -0.030 | -3 | 0.018 |
IRAK4 |
0.649 | -0.123 | 1 | 0.712 |
NEK3 |
0.648 | 0.017 | 1 | 0.684 |
CDK4 |
0.648 | 0.041 | 1 | 0.731 |
KHS2 |
0.647 | -0.069 | 1 | 0.751 |
TTBK1 |
0.647 | -0.099 | 2 | 0.590 |
BUB1 |
0.646 | -0.072 | -5 | 0.500 |
PDHK3_TYR |
0.644 | -0.004 | 4 | 0.918 |
SLK |
0.644 | -0.125 | -2 | 0.534 |
OSR1 |
0.644 | -0.131 | 2 | 0.748 |
PDHK1_TYR |
0.644 | 0.050 | -1 | 0.870 |
LOK |
0.643 | -0.131 | -2 | 0.548 |
BMPR2_TYR |
0.642 | 0.050 | -1 | 0.878 |
PKCI |
0.642 | -0.094 | 2 | 0.678 |
PAK5 |
0.642 | -0.085 | -2 | 0.438 |
PKN1 |
0.642 | -0.100 | -3 | 0.085 |
ROCK1 |
0.642 | -0.101 | -3 | 0.064 |
MAP2K6_TYR |
0.641 | 0.012 | -1 | 0.860 |
YSK1 |
0.641 | -0.098 | 2 | 0.752 |
MAP2K4_TYR |
0.641 | 0.015 | -1 | 0.846 |
PKCT |
0.640 | -0.131 | 2 | 0.663 |
RIPK2 |
0.640 | -0.127 | 1 | 0.662 |
PKCE |
0.639 | -0.100 | 2 | 0.647 |
HASPIN |
0.639 | -0.037 | -1 | 0.663 |
AAK1 |
0.638 | 0.040 | 1 | 0.636 |
PDHK4_TYR |
0.638 | -0.036 | 2 | 0.862 |
ASK1 |
0.637 | -0.104 | 1 | 0.694 |
PAK4 |
0.636 | -0.075 | -2 | 0.449 |
PHKG2 |
0.635 | -0.140 | -3 | 0.093 |
STK33 |
0.634 | -0.089 | 2 | 0.580 |
MYO3B |
0.634 | -0.070 | 2 | 0.771 |
TESK1_TYR |
0.633 | -0.090 | 3 | 0.864 |
PKMYT1_TYR |
0.632 | -0.057 | 3 | 0.839 |
EPHA6 |
0.632 | 0.047 | -1 | 0.858 |
MYO3A |
0.631 | -0.094 | 1 | 0.712 |
MAP2K7_TYR |
0.630 | -0.179 | 2 | 0.837 |
PKG1 |
0.629 | -0.101 | -2 | 0.386 |
STLK3 |
0.629 | -0.138 | 1 | 0.678 |
EPHB4 |
0.627 | -0.007 | -1 | 0.818 |
EPHA4 |
0.626 | 0.014 | 2 | 0.764 |
PINK1_TYR |
0.624 | -0.164 | 1 | 0.805 |
TXK |
0.623 | -0.015 | 1 | 0.834 |
PTK2 |
0.623 | 0.083 | -1 | 0.841 |
FER |
0.623 | -0.036 | 1 | 0.850 |
SYK |
0.622 | 0.046 | -1 | 0.812 |
EPHB2 |
0.622 | 0.015 | -1 | 0.801 |
SRMS |
0.622 | 0.003 | 1 | 0.824 |
BLK |
0.622 | 0.031 | -1 | 0.798 |
LIMK2_TYR |
0.621 | -0.129 | -3 | 0.100 |
TAO1 |
0.621 | -0.148 | 1 | 0.662 |
FGR |
0.620 | -0.070 | 1 | 0.818 |
INSRR |
0.619 | -0.040 | 3 | 0.750 |
EPHB3 |
0.619 | -0.005 | -1 | 0.800 |
EPHB1 |
0.619 | -0.019 | 1 | 0.803 |
LCK |
0.618 | -0.015 | -1 | 0.790 |
LIMK1_TYR |
0.618 | -0.163 | 2 | 0.820 |
YANK3 |
0.618 | -0.083 | 2 | 0.389 |
HCK |
0.618 | -0.023 | -1 | 0.780 |
DDR1 |
0.618 | -0.104 | 4 | 0.829 |
JAK3 |
0.617 | -0.071 | 1 | 0.729 |
TNK2 |
0.617 | -0.025 | 3 | 0.777 |
FYN |
0.616 | -0.001 | -1 | 0.769 |
RET |
0.616 | -0.159 | 1 | 0.742 |
YES1 |
0.616 | -0.075 | -1 | 0.771 |
ABL2 |
0.615 | -0.054 | -1 | 0.755 |
MST1R |
0.615 | -0.116 | 3 | 0.805 |
JAK2 |
0.615 | -0.107 | 1 | 0.738 |
TYK2 |
0.614 | -0.126 | 1 | 0.737 |
CSF1R |
0.614 | -0.098 | 3 | 0.792 |
FLT1 |
0.613 | -0.051 | -1 | 0.854 |
ROS1 |
0.612 | -0.118 | 3 | 0.760 |
FGFR2 |
0.612 | -0.085 | 3 | 0.805 |
EPHA7 |
0.611 | -0.011 | 2 | 0.762 |
EPHA3 |
0.611 | -0.024 | 2 | 0.740 |
EPHA5 |
0.611 | 0.007 | 2 | 0.757 |
TYRO3 |
0.611 | -0.143 | 3 | 0.782 |
ABL1 |
0.611 | -0.065 | -1 | 0.740 |
KIT |
0.611 | -0.090 | 3 | 0.793 |
MET |
0.610 | -0.074 | 3 | 0.792 |
ITK |
0.610 | -0.074 | -1 | 0.747 |
EPHA8 |
0.608 | -0.016 | -1 | 0.798 |
KDR |
0.608 | -0.094 | 3 | 0.769 |
TEK |
0.607 | -0.076 | 3 | 0.732 |
NTRK1 |
0.607 | -0.075 | -1 | 0.778 |
LYN |
0.606 | -0.034 | 3 | 0.705 |
ERBB2 |
0.606 | -0.069 | 1 | 0.719 |
FGFR3 |
0.606 | -0.077 | 3 | 0.782 |
FGFR1 |
0.605 | -0.085 | 3 | 0.776 |
MERTK |
0.605 | -0.069 | 3 | 0.789 |
FLT3 |
0.605 | -0.100 | 3 | 0.775 |
BMX |
0.605 | -0.057 | -1 | 0.666 |
EGFR |
0.604 | -0.040 | 1 | 0.631 |
SRC |
0.604 | -0.043 | -1 | 0.748 |
JAK1 |
0.603 | -0.047 | 1 | 0.679 |
BTK |
0.603 | -0.092 | -1 | 0.687 |
NEK10_TYR |
0.602 | -0.095 | 1 | 0.650 |
FRK |
0.602 | -0.056 | -1 | 0.796 |
PDGFRB |
0.602 | -0.142 | 3 | 0.797 |
TEC |
0.602 | -0.068 | -1 | 0.655 |
PTK2B |
0.601 | -0.037 | -1 | 0.691 |
NTRK3 |
0.601 | -0.080 | -1 | 0.732 |
ERBB4 |
0.600 | -0.008 | 1 | 0.666 |
INSR |
0.600 | -0.074 | 3 | 0.721 |
EPHA2 |
0.599 | -0.012 | -1 | 0.783 |
TNNI3K_TYR |
0.599 | -0.105 | 1 | 0.726 |
AXL |
0.599 | -0.120 | 3 | 0.793 |
FLT4 |
0.599 | -0.091 | 3 | 0.756 |
NTRK2 |
0.599 | -0.095 | 3 | 0.757 |
EPHA1 |
0.599 | -0.070 | 3 | 0.774 |
PDGFRA |
0.598 | -0.133 | 3 | 0.787 |
FGFR4 |
0.597 | -0.065 | -1 | 0.749 |
MATK |
0.597 | -0.100 | -1 | 0.691 |
PTK6 |
0.597 | -0.140 | -1 | 0.660 |
YANK2 |
0.596 | -0.092 | 2 | 0.396 |
TNK1 |
0.596 | -0.138 | 3 | 0.767 |
ALK |
0.596 | -0.109 | 3 | 0.714 |
CSK |
0.595 | -0.091 | 2 | 0.763 |
DDR2 |
0.595 | -0.102 | 3 | 0.745 |
LTK |
0.594 | -0.113 | 3 | 0.742 |
ZAP70 |
0.594 | -0.030 | -1 | 0.717 |
WEE1_TYR |
0.592 | -0.109 | -1 | 0.688 |
IGF1R |
0.589 | -0.068 | 3 | 0.663 |
FES |
0.582 | -0.052 | -1 | 0.635 |
MUSK |
0.577 | -0.086 | 1 | 0.615 |