Motif 1220 (n=98)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00762 | UBE2C | S3 | ochoa | Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| O15254 | ACOX3 | S3 | ochoa | Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) | Oxidizes the CoA-esters of 2-methyl-branched fatty acids. {ECO:0000250|UniProtKB:Q63448}. |
| O15294 | OGT | S3 | ochoa|psp | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:26237509, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:34667079, ECO:0000269|PubMed:37541260, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085). {ECO:0000269|PubMed:31527085}. |
| O43264 | ZW10 | S3 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| O60220 | TIMM8A | S3 | ochoa | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
| O60503 | ADCY9 | S3 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60762 | DPM1 | S3 | ochoa | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. {ECO:0000269|PubMed:10835346}. |
| O75381 | PEX14 | S3 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O76094 | SRP72 | S3 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O95070 | YIF1A | Y3 | ochoa | Protein YIF1A (54TMp) (YIP1-interacting factor homolog A) | Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000269|PubMed:15990086}. |
| O95238 | SPDEF | S3 | ochoa | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
| P00338 | LDHA | T3 | psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00492 | HPRT1 | T3 | ochoa | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| P05386 | RPLP1 | S3 | ochoa | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | Plays an important role in the elongation step of protein synthesis. |
| P15121 | AKR1B1 | S3 | ochoa | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| P16949 | STMN1 | S3 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P19484 | TFEB | S3 | psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20339 | RAB5A | S3 | ochoa | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P31321 | PRKAR1B | S3 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
| P35222 | CTNNB1 | T3 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35548 | MSX2 | S3 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P35568 | IRS1 | S3 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P41182 | BCL6 | S3 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P42858 | HTT | T3 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P48426 | PIP4K2A | T3 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}. |
| P48643 | CCT5 | S3 | ochoa | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49356 | FNTB | S3 | ochoa | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}. |
| P49790 | NUP153 | S3 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50851 | LRBA | S3 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51610 | HCFC1 | S3 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P55072 | VCP | S3 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56134 | ATP5MF | S3 | ochoa | ATP synthase F(0) complex subunit f, mitochondrial (ATP synthase membrane subunit f) | Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P59768 | GNG2 | S3 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}. |
| P61019 | RAB2A | Y3 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P78371 | CCT2 | S3 | ochoa|psp | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q01658 | DR1 | S3 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q04864 | REL | S3 | ochoa | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q05329 | GAD2 | S3 | psp | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) | Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}. |
| Q08AG7 | MZT1 | S3 | ochoa | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q13077 | TRAF1 | S3 | ochoa | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
| Q13596 | SNX1 | S3 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13601 | KRR1 | S3 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q15847 | ADIRF | S3 | ochoa | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}. |
| Q16513 | PKN2 | S3 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16576 | RBBP7 | S3 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16877 | PFKFB4 | S3 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. |
| Q5JSH3 | WDR44 | S3 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5RL73 | RBM48 | S3 | ochoa | RNA-binding protein 48 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000305|PubMed:33509932}. |
| Q5SSJ5 | HP1BP3 | T3 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T4S7 | UBR4 | T3 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q6P1A2 | LPCAT3 | S3 | ochoa | Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) | Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18195019, PubMed:18772128, PubMed:18782225). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18195019, PubMed:18772128, PubMed:18782225). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250|UniProtKB:Q91V01, ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225}. |
| Q6P2E9 | EDC4 | S3 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PKG0 | LARP1 | T3 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q7KZF4 | SND1 | S3 | ochoa | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q7Z591 | AKNA | S3 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z614 | SNX20 | S3 | ochoa | Sorting nexin-20 (Selectin ligand-interactor cytoplasmic 1) (SLIC-1) | May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. {ECO:0000305|PubMed:18196517}. |
| Q86VP6 | CAND1 | S3 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q8N4Y2 | CRACR2B | S3 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8TCY9 | URGCP | S3 | ochoa | Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) | May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. |
| Q8TDB6 | DTX3L | S3 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8WTW3 | COG1 | T3 | ochoa | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | Required for normal Golgi function. {ECO:0000250}. |
| Q8WXH0 | SYNE2 | S3 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q96B49 | TOMM6 | S3 | ochoa | Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog) | None |
| Q96BD8 | SKA1 | S3 | ochoa | SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) | Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (PubMed:17093495, PubMed:19289083, PubMed:22371557, PubMed:22483620, PubMed:23085020, PubMed:26981768, PubMed:27697923, PubMed:29487209, PubMed:31804178). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:28479321, PubMed:29487209). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17093495, PubMed:19289083, PubMed:23085020, PubMed:28479321, PubMed:29487209). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (PubMed:19289083, PubMed:22371557, PubMed:22454517, PubMed:23085020, PubMed:24413531, PubMed:27697923, PubMed:28479321, PubMed:28495837, PubMed:29487209). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (PubMed:23085020, PubMed:29153323). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (PubMed:26981768). In the complex, it mediates interactions with microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:24413531, PubMed:27667719, PubMed:29153323, PubMed:36592928). It also stimulates AURKB/Aurora B catalytic activity (PubMed:27697923). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q9CPV1, ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:22371557, ECO:0000269|PubMed:22454517, ECO:0000269|PubMed:22483620, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:24413531, ECO:0000269|PubMed:26981768, ECO:0000269|PubMed:27667719, ECO:0000269|PubMed:27697923, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:28495837, ECO:0000269|PubMed:29153323, ECO:0000269|PubMed:29487209, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:36592928}. |
| Q96CN4 | EVI5L | S3 | ochoa | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| Q96P20 | NLRP3 | S5 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96S21 | RAB40C | S3 | ochoa | Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}. |
| Q96S90 | LYSMD1 | S3 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q99594 | TEAD3 | S3 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99622 | C12orf57 | S3 | ochoa | Protein C10 | In brain, may be required for corpus callosum development. {ECO:0000269|PubMed:23453666}. |
| Q9BPY3 | FAM118B | S3 | ochoa | Protein FAM118B | May play a role in Cajal bodies formation. {ECO:0000269|PubMed:24569877}. |
| Q9BQJ4 | TMEM47 | S3 | ochoa | Transmembrane protein 47 (Brain cell membrane protein 1) (Transmembrane 4 superfamily member 10) | Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). {ECO:0000250|UniProtKB:Q9JJG6, ECO:0000250|UniProtKB:Q9XSV3}. |
| Q9BRZ2 | TRIM56 | S3 | ochoa | E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160, ECO:0000269|PubMed:29426904, ECO:0000269|PubMed:31251739, ECO:0000269|PubMed:35952808}. |
| Q9BSM1 | PCGF1 | S3 | ochoa | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}. |
| Q9BWQ6 | YIPF2 | S3 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9BXP2 | SLC12A9 | S3 | ochoa | Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) | May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (PubMed:10871601). May play a role in lysosomal ion flux and osmoregulation (PubMed:38334070). {ECO:0000269|PubMed:10871601, ECO:0000269|PubMed:38334070}. |
| Q9H1K6 | TLNRD1 | S3 | ochoa | Talin rod domain-containing protein 1 (Mesoderm development candidate 1) | Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. {ECO:0000269|PubMed:22179486}. |
| Q9H4A4 | RNPEP | S3 | ochoa | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| Q9H6Q4 | CIAO3 | S3 | ochoa | Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}. |
| Q9HA47 | UCK1 | S3 | ochoa | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
| Q9HB71 | CACYBP | S3 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9NUP7 | TRMT13 | T3 | ochoa | tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) | tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}. |
| Q9NVH1 | DNAJC11 | T3 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NVT9 | ARMC1 | S3 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NWA0 | MED9 | S3 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9P0K8 | FOXJ2 | S3 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
| Q9P0L0 | VAPA | S3 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P1Q0 | VPS54 | S3 | ochoa | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q9P253 | VPS18 | S3 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9UHD2 | TBK1 | S3 | ochoa | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9Y4H2 | IRS2 | S3 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y530 | OARD1 | S3 | ochoa | ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-) | ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23474714, PubMed:23481255). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506). {ECO:0000269|PubMed:21849506, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255}. |
| Q9Y5M8 | SRPRB | S3 | ochoa | Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) | Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}. |
| Q9Y5S1 | TRPV2 | S3 | ochoa | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}. |
| S4R325 | URGCP-MRPS24 | S3 | ochoa | URGCP-MRPS24 readthrough | None |
| S4R3Y5 | MTRNR2L11 | T3 | ochoa | Humanin-like 11 (HN11) (MT-RNR2-like protein 11) | Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}. |
| P19474 | TRIM21 | S3 | Sugiyama | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) | E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 (PubMed:16297862, PubMed:16316627, PubMed:16472766, PubMed:16880511, PubMed:18022694, PubMed:18361920, PubMed:18641315, PubMed:18845142, PubMed:19675099, PubMed:26347139). Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination (PubMed:16880511, PubMed:19675099). Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes (PubMed:16880511). A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome (PubMed:16880511). Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling (PubMed:19675099). Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 (PubMed:18641315). Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway (PubMed:18022694). Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (By similarity). Plays a role in the regulation of the cell cycle progression (PubMed:16880511). Enhances the decapping activity of DCP2 (PubMed:18361920). Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules (PubMed:1985094, PubMed:8666824). At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified (PubMed:8666824). The common feature of these proteins is their ability to bind HY RNAs.2 (PubMed:8666824). Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:26347139). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:26347139). Also regulates autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability (PubMed:36359729). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464). During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation (PubMed:36426955). When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity (PubMed:29743353). Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly (PubMed:36692217). {ECO:0000250|UniProtKB:Q62191, ECO:0000269|PubMed:16297862, ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:16880511, ECO:0000269|PubMed:18022694, ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:18641315, ECO:0000269|PubMed:18845142, ECO:0000269|PubMed:19675099, ECO:0000269|PubMed:1985094, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:29743353, ECO:0000269|PubMed:36359729, ECO:0000269|PubMed:36426955, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:8666824}. |
| Q5S007 | LRRK2 | S3 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.000223 | 3.651 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.000175 | 3.756 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.000158 | 3.800 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.000258 | 3.589 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.000443 | 3.354 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.000386 | 3.413 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.000651 | 3.186 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.000825 | 3.084 |
| R-HSA-74713 | IRS activation | 0.001118 | 2.952 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.001041 | 2.982 |
| R-HSA-112412 | SOS-mediated signalling | 0.002251 | 2.648 |
| R-HSA-622312 | Inflammasomes | 0.001761 | 2.754 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.002184 | 2.661 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.003753 | 2.426 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.002983 | 2.525 |
| R-HSA-198203 | PI3K/AKT activation | 0.003753 | 2.426 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.002783 | 2.555 |
| R-HSA-74749 | Signal attenuation | 0.003753 | 2.426 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.002593 | 2.586 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.003190 | 2.496 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.003713 | 2.430 |
| R-HSA-2586552 | Signaling by Leptin | 0.003753 | 2.426 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.004255 | 2.371 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.004397 | 2.357 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.004622 | 2.335 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.005445 | 2.264 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.006070 | 2.217 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.006070 | 2.217 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.006389 | 2.195 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.006389 | 2.195 |
| R-HSA-9609507 | Protein localization | 0.006837 | 2.165 |
| R-HSA-9634597 | GPER1 signaling | 0.007055 | 2.151 |
| R-HSA-3214847 | HATs acetylate histones | 0.007309 | 2.136 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008548 | 2.068 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.011234 | 1.949 |
| R-HSA-163615 | PKA activation | 0.011234 | 1.949 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.011234 | 1.949 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.011905 | 1.924 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.012177 | 1.914 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.012377 | 1.907 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.011234 | 1.949 |
| R-HSA-4839726 | Chromatin organization | 0.011112 | 1.954 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.012477 | 1.904 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.013155 | 1.881 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.013857 | 1.858 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.014165 | 1.849 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.016282 | 1.788 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.018526 | 1.732 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.017389 | 1.760 |
| R-HSA-9843745 | Adipogenesis | 0.019242 | 1.716 |
| R-HSA-9658195 | Leishmania infection | 0.018319 | 1.737 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.018319 | 1.737 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.017106 | 1.767 |
| R-HSA-9679506 | SARS-CoV Infections | 0.018423 | 1.735 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.019694 | 1.706 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.017389 | 1.760 |
| R-HSA-8852135 | Protein ubiquitination | 0.020111 | 1.697 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 0.033884 | 1.470 |
| R-HSA-4719360 | Defective DPM3 causes DPM3-CDG | 0.033884 | 1.470 |
| R-HSA-4717374 | Defective DPM1 causes DPM1-CDG | 0.033884 | 1.470 |
| R-HSA-4719377 | Defective DPM2 causes DPM2-CDG | 0.033884 | 1.470 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.053665 | 1.270 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.053665 | 1.270 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.060169 | 1.221 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.060169 | 1.221 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.066629 | 1.176 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.066629 | 1.176 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.085746 | 1.067 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.092032 | 1.036 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.098274 | 1.008 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.104475 | 0.981 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.104475 | 0.981 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.104475 | 0.981 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.104475 | 0.981 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.104475 | 0.981 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.104475 | 0.981 |
| R-HSA-8949613 | Cristae formation | 0.022120 | 1.655 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.110633 | 0.956 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.122823 | 0.911 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.122823 | 0.911 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.122823 | 0.911 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.122823 | 0.911 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.031508 | 1.502 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.128856 | 0.890 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.128856 | 0.890 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.035933 | 1.445 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.146709 | 0.834 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.152580 | 0.817 |
| R-HSA-991365 | Activation of GABAB receptors | 0.047110 | 1.327 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.158410 | 0.800 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.158410 | 0.800 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.164200 | 0.785 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.192565 | 0.715 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.192565 | 0.715 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.192565 | 0.715 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.080544 | 1.094 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.214568 | 0.668 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.219976 | 0.658 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.225346 | 0.647 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.225346 | 0.647 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.049734 | 1.303 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.137579 | 0.861 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.137579 | 0.861 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.029200 | 1.535 |
| R-HSA-977444 | GABA B receptor activation | 0.047110 | 1.327 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.027319 | 1.564 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.134848 | 0.870 |
| R-HSA-202040 | G-protein activation | 0.164200 | 0.785 |
| R-HSA-9609690 | HCMV Early Events | 0.062146 | 1.207 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.047116 | 1.327 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.085746 | 1.067 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.166218 | 0.779 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.164200 | 0.785 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.052241 | 1.282 |
| R-HSA-774815 | Nucleosome assembly | 0.052241 | 1.282 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.186969 | 0.728 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.152580 | 0.817 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.158410 | 0.800 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.041959 | 1.377 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.047116 | 1.327 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.060169 | 1.221 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.073045 | 1.136 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.098274 | 1.008 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.140799 | 0.851 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.198123 | 0.703 |
| R-HSA-977443 | GABA receptor activation | 0.080544 | 1.094 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.131595 | 0.881 |
| R-HSA-391251 | Protein folding | 0.034015 | 1.468 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.122823 | 0.911 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.152580 | 0.817 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.082570 | 1.083 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.168651 | 0.773 |
| R-HSA-525793 | Myogenesis | 0.198123 | 0.703 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.156273 | 0.806 |
| R-HSA-1538133 | G0 and Early G1 | 0.230680 | 0.637 |
| R-HSA-9609646 | HCMV Infection | 0.117111 | 0.931 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.033884 | 1.470 |
| R-HSA-888568 | GABA synthesis | 0.040523 | 1.392 |
| R-HSA-162699 | Synthesis of dolichyl-phosphate mannose | 0.053665 | 1.270 |
| R-HSA-5652227 | Fructose biosynthesis | 0.073045 | 1.136 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.104475 | 0.981 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.122823 | 0.911 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.128856 | 0.890 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.134848 | 0.870 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.146709 | 0.834 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.042179 | 1.375 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.181335 | 0.742 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.186969 | 0.728 |
| R-HSA-9033241 | Peroxisomal protein import | 0.078533 | 1.105 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.161372 | 0.792 |
| R-HSA-418597 | G alpha (z) signalling events | 0.070656 | 1.151 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.134848 | 0.870 |
| R-HSA-112399 | IRS-mediated signalling | 0.074561 | 1.127 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.186969 | 0.728 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.230680 | 0.637 |
| R-HSA-418555 | G alpha (s) signalling events | 0.144171 | 0.841 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.047110 | 1.327 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.088743 | 1.052 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.066629 | 1.176 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.098274 | 1.008 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.134848 | 0.870 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.146709 | 0.834 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.070656 | 1.151 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.088743 | 1.052 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.169951 | 0.770 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.023377 | 1.631 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.110633 | 0.956 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.219976 | 0.658 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.090831 | 1.042 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.122823 | 0.911 |
| R-HSA-5689603 | UCH proteinases | 0.114684 | 0.940 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.042179 | 1.375 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.042179 | 1.375 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.066629 | 1.176 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.073045 | 1.136 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.073045 | 1.136 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.110633 | 0.956 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.110633 | 0.956 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.116749 | 0.933 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.134848 | 0.870 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.134848 | 0.870 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.146709 | 0.834 |
| R-HSA-9834899 | Specification of the neural plate border | 0.152580 | 0.817 |
| R-HSA-9710421 | Defective pyroptosis | 0.048799 | 1.312 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.164200 | 0.785 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.181335 | 0.742 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.219976 | 0.658 |
| R-HSA-68877 | Mitotic Prometaphase | 0.180622 | 0.743 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.230680 | 0.637 |
| R-HSA-9842663 | Signaling by LTK | 0.104475 | 0.981 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.219976 | 0.658 |
| R-HSA-4086398 | Ca2+ pathway | 0.108027 | 0.966 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.156552 | 0.805 |
| R-HSA-112040 | G-protein mediated events | 0.095049 | 1.022 |
| R-HSA-111885 | Opioid Signalling | 0.045764 | 1.339 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.203642 | 0.691 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.214568 | 0.668 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.103649 | 0.984 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.069572 | 1.158 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.163792 | 0.786 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.190802 | 0.719 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.190802 | 0.719 |
| R-HSA-5205647 | Mitophagy | 0.032958 | 1.482 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.110633 | 0.956 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.128856 | 0.890 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.152580 | 0.817 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.064932 | 1.188 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.192565 | 0.715 |
| R-HSA-422356 | Regulation of insulin secretion | 0.173536 | 0.761 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.043800 | 1.359 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.062146 | 1.207 |
| R-HSA-1268020 | Mitochondrial protein import | 0.084613 | 1.073 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.025255 | 1.598 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.192712 | 0.715 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.044440 | 1.352 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.044440 | 1.352 |
| R-HSA-418990 | Adherens junctions interactions | 0.083053 | 1.081 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.047116 | 1.327 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.053665 | 1.270 |
| R-HSA-448706 | Interleukin-1 processing | 0.079417 | 1.100 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.092032 | 1.036 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.110633 | 0.956 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.055767 | 1.254 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.203642 | 0.691 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.080544 | 1.094 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.230680 | 0.637 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.079375 | 1.100 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.203274 | 0.692 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.147376 | 0.832 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.147376 | 0.832 |
| R-HSA-421270 | Cell-cell junction organization | 0.118262 | 0.927 |
| R-HSA-6807070 | PTEN Regulation | 0.093774 | 1.028 |
| R-HSA-446728 | Cell junction organization | 0.055942 | 1.252 |
| R-HSA-163685 | Integration of energy metabolism | 0.089745 | 1.047 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.111658 | 0.952 |
| R-HSA-68886 | M Phase | 0.060789 | 1.216 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.183372 | 0.737 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.171090 | 0.767 |
| R-HSA-1500931 | Cell-Cell communication | 0.083535 | 1.078 |
| R-HSA-5689877 | Josephin domain DUBs | 0.085746 | 1.067 |
| R-HSA-70370 | Galactose catabolism | 0.134848 | 0.870 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.047110 | 1.327 |
| R-HSA-109704 | PI3K Cascade | 0.061208 | 1.213 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.198123 | 0.703 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.209124 | 0.680 |
| R-HSA-180024 | DARPP-32 events | 0.214568 | 0.668 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.062609 | 1.203 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.029082 | 1.536 |
| R-HSA-68882 | Mitotic Anaphase | 0.222859 | 0.652 |
| R-HSA-1640170 | Cell Cycle | 0.065190 | 1.186 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.158410 | 0.800 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.224662 | 0.648 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.169951 | 0.770 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.022300 | 1.652 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.085746 | 1.067 |
| R-HSA-5652084 | Fructose metabolism | 0.175663 | 0.755 |
| R-HSA-3295583 | TRP channels | 0.198123 | 0.703 |
| R-HSA-9663891 | Selective autophagy | 0.029976 | 1.523 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.225346 | 0.647 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.101479 | 0.994 |
| R-HSA-111933 | Calmodulin induced events | 0.035933 | 1.445 |
| R-HSA-70171 | Glycolysis | 0.178443 | 0.749 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.128856 | 0.890 |
| R-HSA-111997 | CaM pathway | 0.035933 | 1.445 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.158410 | 0.800 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.203642 | 0.691 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.214568 | 0.668 |
| R-HSA-112311 | Neurotransmitter clearance | 0.219976 | 0.658 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.053993 | 1.268 |
| R-HSA-75893 | TNF signaling | 0.072600 | 1.139 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.205779 | 0.687 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.089286 | 1.049 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.205779 | 0.687 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.193288 | 0.714 |
| R-HSA-8876725 | Protein methylation | 0.122823 | 0.911 |
| R-HSA-111996 | Ca-dependent events | 0.047110 | 1.327 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.052241 | 1.282 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.169951 | 0.770 |
| R-HSA-9830364 | Formation of the nephric duct | 0.192565 | 0.715 |
| R-HSA-392499 | Metabolism of proteins | 0.106563 | 0.972 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.073045 | 1.136 |
| R-HSA-9678110 | Attachment and Entry | 0.128856 | 0.890 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.064932 | 1.188 |
| R-HSA-73614 | Pyrimidine salvage | 0.209124 | 0.680 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.114684 | 0.940 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.215676 | 0.666 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.089286 | 1.049 |
| R-HSA-168249 | Innate Immune System | 0.138025 | 0.860 |
| R-HSA-112043 | PLC beta mediated events | 0.082570 | 1.083 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.164200 | 0.785 |
| R-HSA-9694614 | Attachment and Entry | 0.169951 | 0.770 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.186969 | 0.728 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.192565 | 0.715 |
| R-HSA-8956321 | Nucleotide salvage | 0.082570 | 1.083 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.084613 | 1.073 |
| R-HSA-5688426 | Deubiquitination | 0.122915 | 0.910 |
| R-HSA-2559583 | Cellular Senescence | 0.158774 | 0.799 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.029460 | 1.531 |
| R-HSA-1632852 | Macroautophagy | 0.096501 | 1.015 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.086796 | 1.061 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.103649 | 0.984 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.225346 | 0.647 |
| R-HSA-70326 | Glucose metabolism | 0.228468 | 0.641 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.116465 | 0.934 |
| R-HSA-597592 | Post-translational protein modification | 0.179993 | 0.745 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.080544 | 1.094 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.219976 | 0.658 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.119180 | 0.924 |
| R-HSA-9612973 | Autophagy | 0.119436 | 0.923 |
| R-HSA-9824446 | Viral Infection Pathways | 0.052852 | 1.277 |
| R-HSA-5663205 | Infectious disease | 0.024996 | 1.602 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.178443 | 0.749 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.195779 | 0.708 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.092423 | 1.034 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.040582 | 1.392 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.042179 | 1.375 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.198123 | 0.703 |
| R-HSA-1280218 | Adaptive Immune System | 0.118155 | 0.928 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.043016 | 1.366 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.198123 | 0.703 |
| R-HSA-168256 | Immune System | 0.096963 | 1.013 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.183372 | 0.737 |
| R-HSA-1643685 | Disease | 0.116937 | 0.932 |
| R-HSA-1483255 | PI Metabolism | 0.183372 | 0.737 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.125461 | 0.901 |
| R-HSA-2262752 | Cellular responses to stress | 0.054754 | 1.262 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.032367 | 1.490 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.110234 | 0.958 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.103649 | 0.984 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.112453 | 0.949 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.144633 | 0.840 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.230680 | 0.637 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.150604 | 0.822 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.175986 | 0.755 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.023298 | 1.633 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.231001 | 0.636 |
| R-HSA-8951664 | Neddylation | 0.231905 | 0.635 |
| R-HSA-6798695 | Neutrophil degranulation | 0.234519 | 0.630 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.235977 | 0.627 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.235977 | 0.627 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.235977 | 0.627 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.235977 | 0.627 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.235977 | 0.627 |
| R-HSA-9733709 | Cardiogenesis | 0.235977 | 0.627 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.235977 | 0.627 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.235977 | 0.627 |
| R-HSA-68875 | Mitotic Prophase | 0.236073 | 0.627 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.238611 | 0.622 |
| R-HSA-73886 | Chromosome Maintenance | 0.238611 | 0.622 |
| R-HSA-3371556 | Cellular response to heat stress | 0.238611 | 0.622 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.241239 | 0.618 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.241239 | 0.618 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.241239 | 0.618 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.241239 | 0.618 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.244716 | 0.611 |
| R-HSA-392518 | Signal amplification | 0.246464 | 0.608 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.246464 | 0.608 |
| R-HSA-112316 | Neuronal System | 0.248571 | 0.605 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.251654 | 0.599 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.251654 | 0.599 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.251654 | 0.599 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.253868 | 0.595 |
| R-HSA-3371511 | HSF1 activation | 0.256808 | 0.590 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.256808 | 0.590 |
| R-HSA-8853659 | RET signaling | 0.256808 | 0.590 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.258961 | 0.587 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.261927 | 0.582 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.261927 | 0.582 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.261927 | 0.582 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.261927 | 0.582 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.267011 | 0.573 |
| R-HSA-74217 | Purine salvage | 0.267011 | 0.573 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.267011 | 0.573 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.272061 | 0.565 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.272061 | 0.565 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.272061 | 0.565 |
| R-HSA-9648002 | RAS processing | 0.272061 | 0.565 |
| R-HSA-201556 | Signaling by ALK | 0.272061 | 0.565 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.277076 | 0.557 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.277076 | 0.557 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.277076 | 0.557 |
| R-HSA-5260271 | Diseases of Immune System | 0.277076 | 0.557 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.277076 | 0.557 |
| R-HSA-9646399 | Aggrephagy | 0.277076 | 0.557 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.282056 | 0.550 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.282056 | 0.550 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.282056 | 0.550 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.282056 | 0.550 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.282056 | 0.550 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.284429 | 0.546 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.286973 | 0.542 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.287003 | 0.542 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.287003 | 0.542 |
| R-HSA-449147 | Signaling by Interleukins | 0.287107 | 0.542 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.289517 | 0.538 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.291916 | 0.535 |
| R-HSA-74160 | Gene expression (Transcription) | 0.294406 | 0.531 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.296795 | 0.528 |
| R-HSA-8854214 | TBC/RABGAPs | 0.296795 | 0.528 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.296795 | 0.528 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.300474 | 0.522 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.301641 | 0.521 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.304063 | 0.517 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.306454 | 0.514 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.306454 | 0.514 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.306454 | 0.514 |
| R-HSA-9824272 | Somitogenesis | 0.306454 | 0.514 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.306454 | 0.514 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.310735 | 0.508 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.311234 | 0.507 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.311234 | 0.507 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.311234 | 0.507 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.311234 | 0.507 |
| R-HSA-75153 | Apoptotic execution phase | 0.311234 | 0.507 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.315982 | 0.500 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.315982 | 0.500 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.317410 | 0.498 |
| R-HSA-166520 | Signaling by NTRKs | 0.317410 | 0.498 |
| R-HSA-69242 | S Phase | 0.317410 | 0.498 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.319280 | 0.496 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.324979 | 0.488 |
| R-HSA-9766229 | Degradation of CDH1 | 0.325380 | 0.488 |
| R-HSA-73893 | DNA Damage Bypass | 0.325380 | 0.488 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.325380 | 0.488 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.327498 | 0.485 |
| R-HSA-9748787 | Azathioprine ADME | 0.330030 | 0.481 |
| R-HSA-73887 | Death Receptor Signaling | 0.332527 | 0.478 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.334649 | 0.475 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.334649 | 0.475 |
| R-HSA-2514856 | The phototransduction cascade | 0.334649 | 0.475 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.335038 | 0.475 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.339237 | 0.469 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.339237 | 0.469 |
| R-HSA-9610379 | HCMV Late Events | 0.340052 | 0.468 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.342339 | 0.466 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.343793 | 0.464 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.343793 | 0.464 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.343793 | 0.464 |
| R-HSA-1221632 | Meiotic synapsis | 0.343793 | 0.464 |
| R-HSA-877300 | Interferon gamma signaling | 0.345055 | 0.462 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.348318 | 0.458 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.352812 | 0.452 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.357275 | 0.447 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.358789 | 0.445 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.361708 | 0.442 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.361708 | 0.442 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.366111 | 0.436 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.366111 | 0.436 |
| R-HSA-1483257 | Phospholipid metabolism | 0.370039 | 0.432 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.370483 | 0.431 |
| R-HSA-191859 | snRNP Assembly | 0.370483 | 0.431 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.370483 | 0.431 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.370483 | 0.431 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.371911 | 0.430 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.374800 | 0.426 |
| R-HSA-72306 | tRNA processing | 0.374800 | 0.426 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.374826 | 0.426 |
| R-HSA-72766 | Translation | 0.375897 | 0.425 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.377256 | 0.423 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.379139 | 0.421 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.379139 | 0.421 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.379139 | 0.421 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.383422 | 0.416 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.383422 | 0.416 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.387038 | 0.412 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.387676 | 0.412 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.387676 | 0.412 |
| R-HSA-8848021 | Signaling by PTK6 | 0.387676 | 0.412 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.396097 | 0.402 |
| R-HSA-168255 | Influenza Infection | 0.396754 | 0.401 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.400265 | 0.398 |
| R-HSA-212436 | Generic Transcription Pathway | 0.400890 | 0.397 |
| R-HSA-9830369 | Kidney development | 0.404404 | 0.393 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.404404 | 0.393 |
| R-HSA-5218859 | Regulated Necrosis | 0.408514 | 0.389 |
| R-HSA-69275 | G2/M Transition | 0.413587 | 0.383 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.416651 | 0.380 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.416651 | 0.380 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.416651 | 0.380 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.418355 | 0.378 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.418355 | 0.378 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.420678 | 0.376 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.420678 | 0.376 |
| R-HSA-5617833 | Cilium Assembly | 0.423103 | 0.374 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.424677 | 0.372 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.424677 | 0.372 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.424677 | 0.372 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.425470 | 0.371 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.427832 | 0.369 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.428649 | 0.368 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.428649 | 0.368 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.428649 | 0.368 |
| R-HSA-380287 | Centrosome maturation | 0.436512 | 0.360 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.436512 | 0.360 |
| R-HSA-917937 | Iron uptake and transport | 0.436512 | 0.360 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.444522 | 0.352 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.448105 | 0.349 |
| R-HSA-5619084 | ABC transporter disorders | 0.448105 | 0.349 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.459462 | 0.338 |
| R-HSA-5357801 | Programmed Cell Death | 0.460356 | 0.337 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.463196 | 0.334 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.463196 | 0.334 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.465358 | 0.332 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.466904 | 0.331 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.466904 | 0.331 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.470587 | 0.327 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.474244 | 0.324 |
| R-HSA-1500620 | Meiosis | 0.474244 | 0.324 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.477877 | 0.321 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.477877 | 0.321 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.478460 | 0.320 |
| R-HSA-70268 | Pyruvate metabolism | 0.485068 | 0.314 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.485068 | 0.314 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.488627 | 0.311 |
| R-HSA-156902 | Peptide chain elongation | 0.488627 | 0.311 |
| R-HSA-199991 | Membrane Trafficking | 0.491349 | 0.309 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.495671 | 0.305 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.495671 | 0.305 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.499157 | 0.302 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.502619 | 0.299 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.506057 | 0.296 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.509472 | 0.293 |
| R-HSA-1474290 | Collagen formation | 0.512863 | 0.290 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.516231 | 0.287 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.519576 | 0.284 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.519576 | 0.284 |
| R-HSA-72312 | rRNA processing | 0.519956 | 0.284 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.522898 | 0.282 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.522898 | 0.282 |
| R-HSA-1296071 | Potassium Channels | 0.522898 | 0.282 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.522898 | 0.282 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.523260 | 0.281 |
| R-HSA-15869 | Metabolism of nucleotides | 0.528412 | 0.277 |
| R-HSA-913531 | Interferon Signaling | 0.529309 | 0.276 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.529475 | 0.276 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.529475 | 0.276 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.529475 | 0.276 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.535961 | 0.271 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.539171 | 0.268 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.539171 | 0.268 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.539171 | 0.268 |
| R-HSA-162582 | Signal Transduction | 0.539927 | 0.268 |
| R-HSA-382551 | Transport of small molecules | 0.540740 | 0.267 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.542358 | 0.266 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.542358 | 0.266 |
| R-HSA-192823 | Viral mRNA Translation | 0.545524 | 0.263 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.548669 | 0.261 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.551147 | 0.259 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.551791 | 0.258 |
| R-HSA-9833110 | RSV-host interactions | 0.551791 | 0.258 |
| R-HSA-418346 | Platelet homeostasis | 0.557973 | 0.253 |
| R-HSA-69239 | Synthesis of DNA | 0.561032 | 0.251 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.561032 | 0.251 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.561032 | 0.251 |
| R-HSA-211000 | Gene Silencing by RNA | 0.561032 | 0.251 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.564070 | 0.249 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.564070 | 0.249 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.564070 | 0.249 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.564070 | 0.249 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.567087 | 0.246 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.567087 | 0.246 |
| R-HSA-418594 | G alpha (i) signalling events | 0.568491 | 0.245 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.576014 | 0.240 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.576014 | 0.240 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.576014 | 0.240 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.578949 | 0.237 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.587635 | 0.231 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.590490 | 0.229 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.591958 | 0.228 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.593326 | 0.227 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.593326 | 0.227 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.596142 | 0.225 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.596142 | 0.225 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.601717 | 0.221 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.601717 | 0.221 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.601717 | 0.221 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.607216 | 0.217 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.609937 | 0.215 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.609937 | 0.215 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.615323 | 0.211 |
| R-HSA-69206 | G1/S Transition | 0.620635 | 0.207 |
| R-HSA-194138 | Signaling by VEGF | 0.620635 | 0.207 |
| R-HSA-1474165 | Reproduction | 0.636140 | 0.196 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.638662 | 0.195 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.640660 | 0.193 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.641168 | 0.193 |
| R-HSA-9909396 | Circadian clock | 0.641168 | 0.193 |
| R-HSA-195721 | Signaling by WNT | 0.646388 | 0.190 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.669919 | 0.174 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.672209 | 0.172 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.678985 | 0.168 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.681213 | 0.167 |
| R-HSA-2187338 | Visual phototransduction | 0.681213 | 0.167 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.681549 | 0.167 |
| R-HSA-9758941 | Gastrulation | 0.685623 | 0.164 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.687805 | 0.163 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.692125 | 0.160 |
| R-HSA-69306 | DNA Replication | 0.694262 | 0.158 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.696385 | 0.157 |
| R-HSA-1989781 | PPARA activates gene expression | 0.698493 | 0.156 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.702666 | 0.153 |
| R-HSA-162587 | HIV Life Cycle | 0.702666 | 0.153 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.702666 | 0.153 |
| R-HSA-9711097 | Cellular response to starvation | 0.704731 | 0.152 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.704731 | 0.152 |
| R-HSA-8953854 | Metabolism of RNA | 0.708588 | 0.150 |
| R-HSA-109581 | Apoptosis | 0.712850 | 0.147 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.713799 | 0.146 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.716826 | 0.145 |
| R-HSA-5619102 | SLC transporter disorders | 0.722687 | 0.141 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.753703 | 0.123 |
| R-HSA-3781865 | Diseases of glycosylation | 0.755417 | 0.122 |
| R-HSA-983712 | Ion channel transport | 0.763808 | 0.117 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.778430 | 0.109 |
| R-HSA-428157 | Sphingolipid metabolism | 0.782801 | 0.106 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.784314 | 0.106 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.785816 | 0.105 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.785816 | 0.105 |
| R-HSA-9748784 | Drug ADME | 0.808489 | 0.092 |
| R-HSA-5668914 | Diseases of metabolism | 0.817758 | 0.087 |
| R-HSA-162906 | HIV Infection | 0.820179 | 0.086 |
| R-HSA-8939211 | ESR-mediated signaling | 0.832341 | 0.080 |
| R-HSA-416476 | G alpha (q) signalling events | 0.861255 | 0.065 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.870660 | 0.060 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.875122 | 0.058 |
| R-HSA-556833 | Metabolism of lipids | 0.904480 | 0.044 |
| R-HSA-422475 | Axon guidance | 0.904973 | 0.043 |
| R-HSA-8957322 | Metabolism of steroids | 0.909003 | 0.041 |
| R-HSA-1474244 | Extracellular matrix organization | 0.913382 | 0.039 |
| R-HSA-388396 | GPCR downstream signalling | 0.915792 | 0.038 |
| R-HSA-109582 | Hemostasis | 0.919947 | 0.036 |
| R-HSA-9675108 | Nervous system development | 0.923099 | 0.035 |
| R-HSA-73894 | DNA Repair | 0.929405 | 0.032 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.930884 | 0.031 |
| R-HSA-372790 | Signaling by GPCR | 0.945077 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.946033 | 0.024 |
| R-HSA-8978868 | Fatty acid metabolism | 0.949721 | 0.022 |
| R-HSA-1266738 | Developmental Biology | 0.968461 | 0.014 |
| R-HSA-1430728 | Metabolism | 0.974851 | 0.011 |
| R-HSA-500792 | GPCR ligand binding | 0.986247 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.988830 | 0.005 |
| R-HSA-9709957 | Sensory Perception | 0.999880 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MAPKAPK2 |
0.545 | 0.113 | -3 | 0.241 |
PRKD2 |
0.545 | 0.144 | -3 | 0.299 |
SBK |
0.542 | 0.085 | -3 | 0.237 |
PRKD1 |
0.539 | 0.122 | -3 | 0.189 |
CLK2 |
0.539 | 0.089 | -3 | 0.251 |
MAPKAPK3 |
0.538 | 0.128 | -3 | 0.250 |
CLK3 |
0.537 | 0.091 | 1 | 0.832 |
PRKX |
0.536 | 0.060 | -3 | 0.353 |
LATS2 |
0.536 | 0.085 | -5 | 0.500 |
CAMK2D |
0.533 | 0.115 | -3 | 0.207 |
RSK2 |
0.532 | 0.046 | -3 | 0.218 |
PIM3 |
0.532 | 0.043 | -3 | 0.199 |
NUAK2 |
0.532 | 0.145 | -3 | 0.285 |
CLK1 |
0.531 | 0.090 | -3 | 0.299 |
CHK1 |
0.531 | 0.152 | -3 | 0.277 |
PKACB |
0.531 | 0.044 | -2 | 0.051 |
ERK5 |
0.531 | 0.122 | 1 | 0.866 |
CAMK2A |
0.531 | 0.100 | 2 | 0.691 |
CLK4 |
0.530 | 0.067 | -3 | 0.254 |
PIM1 |
0.530 | 0.049 | -3 | 0.235 |
NDR2 |
0.530 | 0.046 | -3 | 0.240 |
PAK6 |
0.530 | 0.132 | -2 | 0.082 |
PRKD3 |
0.527 | 0.086 | -3 | 0.261 |
AURC |
0.526 | 0.032 | -2 | 0.051 |
P90RSK |
0.526 | 0.032 | -3 | 0.180 |
DYRK2 |
0.526 | 0.078 | 1 | 0.807 |
PKACA |
0.525 | 0.037 | -2 | 0.043 |
CDC7 |
0.525 | 0.035 | 1 | 0.725 |
SRPK1 |
0.524 | 0.025 | -3 | 0.146 |
JNK2 |
0.524 | 0.115 | 1 | 0.738 |
NUAK1 |
0.524 | 0.126 | -3 | 0.302 |
CAMK2B |
0.524 | 0.088 | 2 | 0.681 |
CAMK1B |
0.524 | 0.078 | -3 | 0.216 |
CAMK1D |
0.523 | 0.087 | -3 | 0.310 |
SKMLCK |
0.522 | 0.063 | -2 | 0.081 |
RSK4 |
0.521 | 0.018 | -3 | 0.222 |
PIM2 |
0.521 | 0.041 | -3 | 0.238 |
CDKL5 |
0.521 | 0.019 | -3 | 0.124 |
AKT2 |
0.520 | 0.027 | -3 | 0.242 |
DCAMKL1 |
0.520 | 0.150 | -3 | 0.350 |
ICK |
0.520 | 0.029 | -3 | 0.147 |
NDR1 |
0.520 | 0.029 | -3 | 0.252 |
HIPK4 |
0.520 | 0.033 | 1 | 0.820 |
P38B |
0.519 | 0.101 | 1 | 0.782 |
MTOR |
0.519 | -0.017 | 1 | 0.694 |
AMPKA2 |
0.519 | 0.098 | -3 | 0.300 |
PKACG |
0.519 | 0.019 | -2 | 0.073 |
NLK |
0.519 | 0.085 | 1 | 0.818 |
PDHK4 |
0.519 | -0.005 | 1 | 0.709 |
RSK3 |
0.519 | 0.015 | -3 | 0.196 |
P70S6KB |
0.519 | 0.029 | -3 | 0.244 |
DYRK4 |
0.518 | 0.082 | 1 | 0.762 |
MSK1 |
0.518 | 0.004 | -3 | 0.164 |
CDK8 |
0.518 | 0.068 | 1 | 0.761 |
COT |
0.518 | -0.058 | 2 | 0.705 |
P38A |
0.517 | 0.098 | 1 | 0.820 |
ATR |
0.517 | 0.019 | 1 | 0.709 |
TSSK1 |
0.517 | 0.109 | -3 | 0.281 |
JNK3 |
0.517 | 0.088 | 1 | 0.761 |
CAMK4 |
0.517 | 0.094 | -3 | 0.303 |
PRPK |
0.517 | -0.010 | -1 | 0.259 |
LATS1 |
0.516 | 0.034 | -3 | 0.217 |
SRPK2 |
0.516 | 0.003 | -3 | 0.139 |
CDK19 |
0.516 | 0.071 | 1 | 0.740 |
CDK9 |
0.516 | 0.100 | 1 | 0.763 |
AMPKA1 |
0.516 | 0.086 | -3 | 0.279 |
MOS |
0.516 | -0.023 | 1 | 0.757 |
P38D |
0.516 | 0.104 | 1 | 0.714 |
CDKL1 |
0.516 | -0.015 | -3 | 0.124 |
CDK7 |
0.515 | 0.074 | 1 | 0.780 |
WNK1 |
0.515 | 0.084 | -2 | 0.090 |
DYRK3 |
0.515 | 0.046 | 1 | 0.803 |
CAMK1A |
0.515 | 0.070 | -3 | 0.282 |
IKKB |
0.515 | -0.046 | -2 | 0.130 |
NIK |
0.514 | 0.110 | -3 | 0.217 |
MELK |
0.514 | 0.092 | -3 | 0.301 |
MNK2 |
0.514 | 0.082 | -2 | 0.075 |
MAK |
0.514 | 0.042 | -2 | 0.072 |
MYLK4 |
0.514 | 0.029 | -2 | 0.083 |
HIPK2 |
0.514 | 0.067 | 1 | 0.758 |
MARK4 |
0.514 | 0.047 | 4 | 0.720 |
CDK13 |
0.513 | 0.080 | 1 | 0.761 |
PDHK1 |
0.513 | 0.017 | 1 | 0.676 |
RAF1 |
0.513 | -0.001 | 1 | 0.677 |
CHK2 |
0.513 | 0.069 | -3 | 0.276 |
IKKA |
0.512 | -0.041 | -2 | 0.115 |
PINK1 |
0.512 | 0.089 | 1 | 0.791 |
DAPK2 |
0.512 | 0.036 | -3 | 0.194 |
SIK |
0.512 | 0.059 | -3 | 0.285 |
CAMK2G |
0.512 | -0.024 | 2 | 0.678 |
CDK1 |
0.512 | 0.073 | 1 | 0.765 |
QSK |
0.511 | 0.057 | 4 | 0.695 |
CAMLCK |
0.511 | 0.013 | -2 | 0.107 |
HIPK1 |
0.511 | 0.056 | 1 | 0.811 |
MOK |
0.511 | 0.063 | 1 | 0.847 |
AURB |
0.511 | 0.004 | -2 | 0.050 |
CDK10 |
0.511 | 0.089 | 1 | 0.758 |
PAK5 |
0.511 | 0.062 | -2 | 0.067 |
MNK1 |
0.510 | 0.092 | -2 | 0.069 |
MAPKAPK5 |
0.510 | 0.022 | -3 | 0.118 |
TSSK2 |
0.510 | 0.061 | -5 | 0.500 |
DYRK1B |
0.510 | 0.053 | 1 | 0.777 |
PKG2 |
0.510 | 0.019 | -2 | 0.053 |
PKN2 |
0.510 | 0.056 | -3 | 0.257 |
SRPK3 |
0.510 | -0.003 | -3 | 0.109 |
ERK1 |
0.509 | 0.079 | 1 | 0.768 |
DYRK1A |
0.509 | 0.042 | 1 | 0.797 |
BMPR1B |
0.509 | -0.013 | 1 | 0.722 |
CDK12 |
0.509 | 0.078 | 1 | 0.741 |
GRK5 |
0.509 | -0.085 | -3 | 0.094 |
CAMK1G |
0.509 | 0.034 | -3 | 0.236 |
DSTYK |
0.509 | -0.071 | 2 | 0.730 |
PAK1 |
0.508 | 0.018 | -2 | 0.065 |
P38G |
0.508 | 0.084 | 1 | 0.702 |
GRK6 |
0.508 | -0.018 | 1 | 0.699 |
MSK2 |
0.507 | -0.034 | -3 | 0.135 |
CDK18 |
0.507 | 0.067 | 1 | 0.745 |
P70S6K |
0.507 | 0.003 | -3 | 0.196 |
PKN3 |
0.506 | 0.002 | -3 | 0.192 |
MARK3 |
0.506 | 0.054 | 4 | 0.658 |
MST4 |
0.506 | 0.024 | 2 | 0.707 |
AKT1 |
0.506 | 0.023 | -3 | 0.278 |
SMG1 |
0.506 | -0.007 | 1 | 0.663 |
BMPR2 |
0.506 | -0.165 | -2 | 0.110 |
PAK4 |
0.506 | 0.049 | -2 | 0.065 |
SGK3 |
0.506 | 0.020 | -3 | 0.250 |
HIPK3 |
0.505 | 0.063 | 1 | 0.789 |
HUNK |
0.505 | -0.002 | 2 | 0.687 |
CDK5 |
0.505 | 0.074 | 1 | 0.797 |
MASTL |
0.504 | -0.060 | -2 | 0.118 |
CHAK2 |
0.504 | -0.010 | -1 | 0.220 |
CAMKK2 |
0.504 | 0.151 | -2 | 0.271 |
FAM20C |
0.504 | 0.014 | 2 | 0.564 |
MARK1 |
0.504 | 0.063 | 4 | 0.673 |
PAK3 |
0.504 | 0.017 | -2 | 0.081 |
QIK |
0.504 | 0.035 | -3 | 0.243 |
BCKDK |
0.504 | -0.044 | -1 | 0.233 |
KIS |
0.504 | 0.021 | 1 | 0.785 |
DCAMKL2 |
0.503 | 0.109 | -3 | 0.357 |
SGK1 |
0.503 | -0.008 | -3 | 0.196 |
AURA |
0.503 | -0.022 | -2 | 0.038 |
GRK7 |
0.503 | -0.025 | 1 | 0.661 |
AKT3 |
0.503 | -0.006 | -3 | 0.207 |
NEK9 |
0.503 | 0.011 | 2 | 0.654 |
DNAPK |
0.503 | 0.021 | 1 | 0.568 |
GRK1 |
0.503 | -0.073 | -2 | 0.079 |
CDK14 |
0.503 | 0.074 | 1 | 0.762 |
CDK17 |
0.502 | 0.072 | 1 | 0.704 |
TGFBR1 |
0.502 | -0.035 | -2 | 0.082 |
BRSK1 |
0.502 | 0.040 | -3 | 0.274 |
DMPK1 |
0.502 | 0.080 | -3 | 0.337 |
JNK1 |
0.502 | 0.074 | 1 | 0.731 |
MRCKA |
0.502 | 0.035 | -3 | 0.293 |
IKKE |
0.501 | -0.016 | 1 | 0.553 |
MRCKB |
0.500 | 0.032 | -3 | 0.289 |
NIM1 |
0.500 | 0.001 | 3 | 0.770 |
ALK2 |
0.500 | -0.031 | -2 | 0.118 |
CK1D |
0.500 | -0.058 | -3 | 0.028 |
TBK1 |
0.499 | -0.032 | 1 | 0.556 |
GRK2 |
0.499 | -0.039 | -2 | 0.074 |
BRSK2 |
0.499 | 0.059 | -3 | 0.296 |
ERK2 |
0.499 | 0.059 | 1 | 0.784 |
MLK2 |
0.499 | -0.019 | 2 | 0.637 |
PKCD |
0.499 | 0.006 | 2 | 0.580 |
RIPK3 |
0.499 | -0.022 | 3 | 0.740 |
SMMLCK |
0.499 | 0.010 | -3 | 0.200 |
CDK2 |
0.499 | 0.049 | 1 | 0.792 |
MARK2 |
0.498 | 0.040 | 4 | 0.621 |
PASK |
0.498 | 0.009 | -3 | 0.165 |
PKCB |
0.498 | 0.017 | 2 | 0.537 |
DLK |
0.498 | -0.060 | 1 | 0.679 |
ULK2 |
0.498 | -0.075 | 2 | 0.595 |
ATM |
0.497 | -0.042 | 1 | 0.643 |
DAPK3 |
0.497 | 0.035 | -3 | 0.277 |
MEK1 |
0.497 | -0.001 | 2 | 0.689 |
CDK3 |
0.497 | 0.069 | 1 | 0.724 |
NEK6 |
0.497 | -0.091 | -2 | 0.111 |
ACVR2B |
0.497 | -0.061 | -2 | 0.072 |
CDK16 |
0.497 | 0.068 | 1 | 0.716 |
CAMKK1 |
0.497 | 0.084 | -2 | 0.274 |
PHKG2 |
0.497 | 0.128 | -3 | 0.369 |
PRP4 |
0.496 | -0.012 | -3 | 0.065 |
CRIK |
0.496 | 0.023 | -3 | 0.229 |
NEK7 |
0.496 | -0.117 | -3 | 0.070 |
PKG1 |
0.496 | 0.014 | -2 | 0.039 |
ALK4 |
0.496 | -0.054 | -2 | 0.076 |
DAPK1 |
0.496 | 0.019 | -3 | 0.242 |
PKCZ |
0.496 | 0.013 | 2 | 0.576 |
GRK3 |
0.496 | -0.045 | -2 | 0.058 |
LKB1 |
0.495 | 0.029 | -3 | 0.130 |
RIPK1 |
0.495 | -0.052 | 1 | 0.671 |
GCN2 |
0.494 | -0.114 | 2 | 0.645 |
PAK2 |
0.494 | -0.026 | -2 | 0.072 |
CK1E |
0.494 | -0.069 | -3 | 0.037 |
TGFBR2 |
0.494 | -0.097 | -2 | 0.077 |
GRK4 |
0.494 | -0.124 | -2 | 0.079 |
BMPR1A |
0.494 | -0.040 | 1 | 0.683 |
WNK3 |
0.494 | -0.050 | 1 | 0.659 |
PHKG1 |
0.494 | 0.046 | -3 | 0.278 |
ULK1 |
0.494 | -0.067 | -3 | 0.068 |
ACVR2A |
0.494 | -0.067 | -2 | 0.066 |
GSK3A |
0.493 | 0.034 | 4 | 0.541 |
PKCG |
0.493 | -0.007 | 2 | 0.536 |
NEK2 |
0.493 | -0.029 | 2 | 0.625 |
CK1A2 |
0.492 | -0.061 | -3 | 0.036 |
GSK3B |
0.492 | 0.037 | 4 | 0.535 |
ROCK2 |
0.492 | 0.034 | -3 | 0.286 |
GAK |
0.492 | 0.048 | 1 | 0.761 |
VRK2 |
0.491 | -0.033 | 1 | 0.751 |
DRAK1 |
0.491 | -0.004 | 1 | 0.661 |
PLK1 |
0.491 | -0.088 | -2 | 0.081 |
PKR |
0.490 | -0.036 | 1 | 0.717 |
MPSK1 |
0.490 | -0.002 | 1 | 0.727 |
TLK2 |
0.490 | -0.071 | 1 | 0.657 |
BRAF |
0.490 | -0.024 | -4 | 0.095 |
MLK1 |
0.489 | -0.120 | 2 | 0.631 |
PBK |
0.489 | 0.057 | 1 | 0.708 |
PKN1 |
0.489 | 0.027 | -3 | 0.247 |
YSK4 |
0.489 | -0.069 | 1 | 0.609 |
PLK3 |
0.489 | -0.065 | 2 | 0.647 |
SSTK |
0.489 | 0.046 | 4 | 0.680 |
CK2A2 |
0.489 | 0.002 | 1 | 0.636 |
PKCI |
0.489 | 0.020 | 2 | 0.544 |
CDK4 |
0.488 | 0.077 | 1 | 0.733 |
PKCH |
0.487 | -0.006 | 2 | 0.518 |
CDK6 |
0.487 | 0.073 | 1 | 0.746 |
PKCA |
0.487 | -0.030 | 2 | 0.527 |
CHAK1 |
0.486 | -0.007 | 2 | 0.582 |
ANKRD3 |
0.486 | -0.135 | 1 | 0.702 |
SNRK |
0.486 | 0.001 | 2 | 0.507 |
ROCK1 |
0.485 | 0.027 | -3 | 0.294 |
TAO3 |
0.485 | 0.022 | 1 | 0.651 |
NEK5 |
0.485 | -0.013 | 1 | 0.693 |
WNK4 |
0.485 | -0.007 | -2 | 0.105 |
IRE1 |
0.485 | -0.028 | 1 | 0.688 |
PKCE |
0.484 | 0.011 | 2 | 0.527 |
CK1A |
0.484 | -0.056 | -3 | 0.014 |
MST3 |
0.483 | -0.003 | 2 | 0.677 |
CK2A1 |
0.483 | 0.007 | 1 | 0.619 |
PERK |
0.483 | -0.080 | -2 | 0.124 |
MLK3 |
0.482 | -0.070 | 2 | 0.551 |
ERK7 |
0.482 | 0.019 | 2 | 0.388 |
MEKK3 |
0.482 | -0.080 | 1 | 0.655 |
BUB1 |
0.482 | 0.005 | -5 | 0.500 |
PLK2 |
0.481 | -0.037 | -3 | 0.051 |
HPK1 |
0.481 | 0.035 | 1 | 0.645 |
SLK |
0.481 | 0.002 | -2 | 0.090 |
LRRK2 |
0.481 | 0.042 | 2 | 0.664 |
CK1G1 |
0.480 | -0.072 | -3 | 0.030 |
LOK |
0.480 | 0.033 | -2 | 0.133 |
GCK |
0.480 | 0.010 | 1 | 0.663 |
MEK5 |
0.480 | -0.087 | 2 | 0.650 |
IRAK4 |
0.480 | 0.015 | 1 | 0.671 |
IRAK1 |
0.479 | -0.028 | -1 | 0.186 |
TTBK2 |
0.479 | -0.119 | 2 | 0.540 |
HRI |
0.479 | -0.103 | -2 | 0.103 |
TLK1 |
0.478 | -0.100 | -2 | 0.081 |
MLK4 |
0.477 | -0.098 | 2 | 0.533 |
PKCT |
0.477 | -0.024 | 2 | 0.521 |
TAO2 |
0.476 | 0.029 | 2 | 0.652 |
NEK4 |
0.476 | 0.025 | 1 | 0.639 |
NEK11 |
0.475 | -0.040 | 1 | 0.636 |
IRE2 |
0.473 | -0.063 | 2 | 0.536 |
TAK1 |
0.472 | -0.054 | 1 | 0.665 |
MEKK2 |
0.472 | -0.095 | 2 | 0.618 |
NEK1 |
0.472 | 0.021 | 1 | 0.654 |
BIKE |
0.472 | 0.052 | 1 | 0.675 |
PDK1 |
0.472 | -0.054 | 1 | 0.647 |
KHS2 |
0.471 | 0.036 | 1 | 0.648 |
HGK |
0.471 | -0.007 | 3 | 0.811 |
PLK4 |
0.471 | -0.078 | 2 | 0.486 |
MEKK1 |
0.471 | -0.118 | 1 | 0.645 |
TNIK |
0.470 | -0.008 | 3 | 0.813 |
KHS1 |
0.470 | 0.026 | 1 | 0.628 |
MEKK6 |
0.470 | -0.004 | 1 | 0.667 |
EEF2K |
0.467 | -0.012 | 3 | 0.802 |
MST2 |
0.467 | -0.112 | 1 | 0.653 |
MINK |
0.467 | -0.042 | 1 | 0.636 |
NEK8 |
0.467 | -0.111 | 2 | 0.623 |
ZAK |
0.466 | -0.134 | 1 | 0.606 |
AAK1 |
0.466 | 0.056 | 1 | 0.612 |
NEK3 |
0.466 | -0.012 | 1 | 0.609 |
STK33 |
0.465 | -0.056 | 2 | 0.471 |
MEK2 |
0.464 | -0.059 | 2 | 0.643 |
CK1G3 |
0.462 | -0.071 | -3 | 0.011 |
MST1 |
0.461 | -0.083 | 1 | 0.633 |
TTBK1 |
0.461 | -0.094 | 2 | 0.466 |
VRK1 |
0.461 | -0.075 | 2 | 0.650 |
RIPK2 |
0.460 | -0.067 | 1 | 0.556 |
MAP3K15 |
0.459 | -0.054 | 1 | 0.599 |
YSK1 |
0.459 | -0.026 | 2 | 0.626 |
HASPIN |
0.458 | -0.028 | -1 | 0.177 |
MYO3B |
0.453 | -0.030 | 2 | 0.635 |
TAO1 |
0.449 | 0.003 | 1 | 0.563 |
ALPHAK3 |
0.449 | -0.072 | -1 | 0.203 |
CK1G2 |
0.446 | -0.075 | -3 | 0.026 |
MYO3A |
0.446 | -0.046 | 1 | 0.637 |
OSR1 |
0.445 | -0.127 | 2 | 0.630 |
YANK3 |
0.444 | -0.045 | 2 | 0.323 |
TTK |
0.444 | -0.109 | -2 | 0.072 |
ASK1 |
0.441 | -0.068 | 1 | 0.580 |
PDHK3_TYR |
0.440 | 0.035 | 4 | 0.799 |
MAP2K6_TYR |
0.437 | -0.005 | -1 | 0.250 |
MAP2K4_TYR |
0.436 | -0.006 | -1 | 0.249 |
PDHK4_TYR |
0.435 | -0.016 | 2 | 0.733 |
BMPR2_TYR |
0.434 | -0.043 | -1 | 0.229 |
LIMK2_TYR |
0.432 | 0.048 | -3 | 0.194 |
STLK3 |
0.431 | -0.131 | 1 | 0.573 |
TESK1_TYR |
0.430 | -0.028 | 3 | 0.852 |
PDHK1_TYR |
0.428 | -0.094 | -1 | 0.225 |
MAP2K7_TYR |
0.427 | -0.084 | 2 | 0.699 |
PKMYT1_TYR |
0.426 | -0.060 | 3 | 0.823 |
YANK2 |
0.424 | -0.052 | 2 | 0.331 |
DDR1 |
0.421 | -0.004 | 4 | 0.709 |
PINK1_TYR |
0.419 | -0.114 | 1 | 0.715 |
LIMK1_TYR |
0.417 | -0.080 | 2 | 0.664 |
EPHA6 |
0.413 | -0.083 | -1 | 0.218 |
SRMS |
0.411 | -0.082 | 1 | 0.713 |
FGR |
0.410 | -0.111 | 1 | 0.741 |
RET |
0.409 | -0.122 | 1 | 0.655 |
FER |
0.409 | -0.120 | 1 | 0.735 |
DDR2 |
0.409 | 0.007 | 3 | 0.717 |
EPHA4 |
0.408 | -0.082 | 2 | 0.669 |
EPHB4 |
0.408 | -0.121 | -1 | 0.198 |
TNNI3K_TYR |
0.408 | -0.001 | 1 | 0.680 |
TYK2 |
0.407 | -0.109 | 1 | 0.647 |
NEK10_TYR |
0.406 | -0.024 | 1 | 0.544 |
YES1 |
0.406 | -0.106 | -1 | 0.199 |
TNK2 |
0.405 | -0.070 | 3 | 0.714 |
TXK |
0.405 | -0.102 | 1 | 0.725 |
TYRO3 |
0.403 | -0.127 | 3 | 0.751 |
ABL2 |
0.403 | -0.104 | -1 | 0.201 |
ABL1 |
0.403 | -0.099 | -1 | 0.201 |
INSRR |
0.403 | -0.105 | 3 | 0.729 |
JAK2 |
0.402 | -0.122 | 1 | 0.646 |
TNK1 |
0.402 | -0.049 | 3 | 0.737 |
MST1R |
0.401 | -0.153 | 3 | 0.764 |
WEE1_TYR |
0.401 | -0.076 | -1 | 0.183 |
HCK |
0.401 | -0.124 | -1 | 0.194 |
EPHB1 |
0.401 | -0.127 | 1 | 0.700 |
BMX |
0.401 | -0.090 | -1 | 0.153 |
JAK3 |
0.400 | -0.130 | 1 | 0.632 |
PTK2 |
0.400 | -0.056 | -1 | 0.183 |
ROS1 |
0.400 | -0.126 | 3 | 0.732 |
EPHB3 |
0.400 | -0.130 | -1 | 0.194 |
FGFR2 |
0.399 | -0.124 | 3 | 0.781 |
ITK |
0.399 | -0.120 | -1 | 0.182 |
LCK |
0.399 | -0.123 | -1 | 0.199 |
PTK6 |
0.398 | -0.143 | -1 | 0.179 |
BLK |
0.398 | -0.111 | -1 | 0.192 |
FYN |
0.397 | -0.112 | -1 | 0.183 |
EPHB2 |
0.397 | -0.142 | -1 | 0.185 |
AXL |
0.397 | -0.101 | 3 | 0.738 |
PTK2B |
0.396 | -0.054 | -1 | 0.203 |
CSF1R |
0.396 | -0.151 | 3 | 0.739 |
TEK |
0.396 | -0.116 | 3 | 0.703 |
NTRK1 |
0.396 | -0.120 | -1 | 0.206 |
SYK |
0.396 | -0.099 | -1 | 0.179 |
MERTK |
0.395 | -0.112 | 3 | 0.738 |
JAK1 |
0.395 | -0.059 | 1 | 0.575 |
TEC |
0.395 | -0.115 | -1 | 0.155 |
KIT |
0.394 | -0.142 | 3 | 0.743 |
EPHA3 |
0.394 | -0.119 | 2 | 0.625 |
FGFR3 |
0.394 | -0.109 | 3 | 0.753 |
LTK |
0.394 | -0.080 | 3 | 0.704 |
BTK |
0.394 | -0.154 | -1 | 0.164 |
FGFR1 |
0.394 | -0.111 | 3 | 0.733 |
FLT1 |
0.393 | -0.149 | -1 | 0.187 |
MATK |
0.393 | -0.117 | -1 | 0.168 |
KDR |
0.392 | -0.126 | 3 | 0.715 |
PDGFRB |
0.390 | -0.152 | 3 | 0.754 |
EPHA7 |
0.390 | -0.121 | 2 | 0.644 |
ALK |
0.389 | -0.094 | 3 | 0.683 |
SRC |
0.389 | -0.119 | -1 | 0.182 |
CSK |
0.388 | -0.109 | 2 | 0.646 |
EPHA5 |
0.388 | -0.119 | 2 | 0.646 |
MET |
0.388 | -0.152 | 3 | 0.735 |
FLT3 |
0.388 | -0.154 | 3 | 0.739 |
LYN |
0.387 | -0.140 | 3 | 0.681 |
NTRK3 |
0.387 | -0.137 | -1 | 0.202 |
FLT4 |
0.387 | -0.119 | 3 | 0.728 |
PDGFRA |
0.387 | -0.138 | 3 | 0.753 |
INSR |
0.386 | -0.112 | 3 | 0.703 |
NTRK2 |
0.386 | -0.152 | 3 | 0.723 |
ERBB2 |
0.385 | -0.142 | 1 | 0.605 |
EGFR |
0.384 | -0.105 | 1 | 0.520 |
EPHA1 |
0.384 | -0.131 | 3 | 0.708 |
EPHA8 |
0.383 | -0.134 | -1 | 0.170 |
FGFR4 |
0.382 | -0.127 | -1 | 0.180 |
EPHA2 |
0.380 | -0.114 | -1 | 0.157 |
FRK |
0.379 | -0.151 | -1 | 0.191 |
IGF1R |
0.376 | -0.110 | 3 | 0.655 |
FES |
0.375 | -0.090 | -1 | 0.153 |
ZAP70 |
0.375 | -0.097 | -1 | 0.178 |
MUSK |
0.372 | -0.098 | 1 | 0.529 |
ERBB4 |
0.371 | -0.106 | 1 | 0.559 |