Motif 122 (n=154)

Position-wise Probabilities

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uniprot genes site source protein function
A1X283 SH3PXD2B S491 ochoa SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
A1XBS5 CIBAR1 S241 ochoa CBY1-interacting BAR domain-containing protein 1 Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (PubMed:30404948). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (PubMed:30404948). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (PubMed:30404948). Plays a crucial role in ciliogenesis (PubMed:27528616, PubMed:30395363). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity). {ECO:0000250|UniProtKB:Q8BP22, ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363, ECO:0000269|PubMed:30404948}.
A2A3N6 PIPSL S294 ochoa Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4) Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.
B2RTY4 MYO9A S813 ochoa Unconventional myosin-IXa (Unconventional myosin-9a) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
K7ENP7 None S32 ochoa INO80 complex subunit C None
O14974 PPP1R12A S507 ochoa|psp Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15018 PDZD2 S2341 ochoa PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] None
O15027 SEC16A S1244 psp Protein transport protein Sec16A (SEC16 homolog A) (p250) Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}.
O43312 MTSS1 S271 ochoa Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
O43567 RNF13 S322 ochoa E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786). {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:30595371}.
O60469 DSCAM T274 ochoa Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.
O60934 NBN S518 ochoa Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}.
O75145 PPFIA3 S512 ochoa Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.
O75530 EED S29 ochoa Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.
O94818 NOL4 S248 ochoa Nucleolar protein 4 (Nucleolar-localized protein) None
O95996 APC2 S1164 psp Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like) Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}.
P05107 ITGB2 S489 ochoa Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}.
P21757 MSR1 S27 ochoa Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586). {ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}.
P25054 APC S1389 psp Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P35398 RORA S35 psp Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. {ECO:0000269|PubMed:10478845, ECO:0000269|PubMed:11053433, ECO:0000269|PubMed:11252722, ECO:0000269|PubMed:11554739, ECO:0000269|PubMed:12467577, ECO:0000269|PubMed:14570920, ECO:0000269|PubMed:15781255, ECO:0000269|PubMed:15790933, ECO:0000269|PubMed:16462772, ECO:0000269|PubMed:17512500, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:21499262, ECO:0000269|PubMed:29656859, ECO:0000269|PubMed:7926749, ECO:0000269|PubMed:9328355, ECO:0000269|PubMed:9862959}.
P35869 AHR S436 psp Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}.
P52948 NUP98 S746 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P54296 MYOM2 S828 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P78527 PRKDC S2612 ochoa|psp DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
P78545 ELF3 S215 ochoa ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}.
P78559 MAP1A T1280 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P80192 MAP3K9 S917 ochoa Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.
P98198 ATP8B2 S1181 ochoa Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. {ECO:0000269|PubMed:25315773}.
Q01064 PDE1B S466 ochoa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816). {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:8855339, ECO:0000269|PubMed:9419816}.
Q06413 MEF2C S192 ochoa Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.
Q10571 MN1 S815 ochoa Transcriptional activator MN1 (Probable tumor suppressor protein MN1) Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.
Q12830 BPTF S1827 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12879 GRIN2A S1291 psp Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}.
Q13009 TIAM1 S172 ochoa|psp Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q13490 BIRC2 S138 ochoa Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.
Q13950 RUNX2 S340 ochoa|psp Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.
Q14160 SCRIB S515 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14207 NPAT S1348 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q14674 ESPL1 S1501 ochoa|psp Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.
Q14689 DIP2A S145 ochoa Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}.
Q15018 ABRAXAS2 S354 ochoa BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.
Q15643 TRIP11 S1858 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q15751 HERC1 S1558 ochoa Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
Q2KHR2 RFX7 S1290 ochoa DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}.
Q2M2I8 AAK1 S846 ochoa AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.
Q2TAC6 KIF19 S834 ochoa Kinesin-like protein KIF19 Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. {ECO:0000250}.
Q4AC94 C2CD3 S466 ochoa C2 domain-containing protein 3 Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.
Q4KWH8 PLCH1 S1012 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.
Q52LW3 ARHGAP29 S21 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q53EP0 FNDC3B S393 ochoa Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.
Q5K651 SAMD9 S156 ochoa Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules (PubMed:25428864, PubMed:28157624). May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. {ECO:0000269|PubMed:16960814, ECO:0000269|PubMed:18094730, ECO:0000269|PubMed:21160498, ECO:0000269|PubMed:24029230, ECO:0000269|PubMed:25428864, ECO:0000269|PubMed:28157624}.
Q5XPI4 RNF123 S674 ochoa E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:27312109, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}.
Q68CP9 ARID2 S1300 ochoa AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q68CZ2 TNS3 S379 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6KC79 NIPBL S244 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6MZZ7 CAPN13 S608 ochoa Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13) Probable non-lysosomal thiol-protease. {ECO:0000250}.
Q6PI98 INO80C S32 ochoa INO80 complex subunit C (IES6 homolog) (hIes6) Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Q6PL18 ATAD2 Y750 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6ZN28 MACC1 S116 ochoa Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}.
Q6ZSS7 MFSD6 S733 ochoa Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) None
Q70CQ4 USP31 S914 ochoa Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}.
Q70EL1 USP54 S1250 ochoa Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}.
Q76I76 SSH2 S1353 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q76N89 HECW1 S68 ochoa E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Q7Z5J4 RAI1 S571 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z6G8 ANKS1B S738 ochoa Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Q86VQ1 GLCCI1 S345 ochoa Glucocorticoid-induced transcript 1 protein None
Q86VY9 TMEM200A S323 ochoa Transmembrane protein 200A None
Q86YV5 PRAG1 S231 ochoa Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}.
Q8IUG5 MYO18B S2170 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IVL0 NAV3 S1669 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IVL1 NAV2 S1610 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVL1 NAV2 S1799 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IVT2 MISP S586 ochoa Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IWZ3 ANKHD1 S1591 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IXK2 GALNT12 S555 ochoa Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12) Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Q8IYS0 GRAMD1C S225 ochoa Protein Aster-C (GRAM domain-containing protein 1C) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}.
Q8N0Z3 SPICE1 S811 ochoa Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}.
Q8N1Q1 CA13 S49 ochoa Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) Reversible hydration of carbon dioxide.
Q8N3A8 PARP8 S456 ochoa Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q8N3R9 PALS1 S129 ochoa Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}.
Q8NCN4 RNF169 S339 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8NEV8 EXPH5 S873 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEV8 EXPH5 S876 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEY1 NAV1 S1181 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NEZ4 KMT2C S1919 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8TAB3 PCDH19 S830 ochoa Protocadherin-19 Calcium-dependent cell-adhesion protein. {ECO:0000250|UniProtKB:F8W3X3}.
Q8TBM8 DNAJB14 S69 ochoa DnaJ homolog subfamily B member 14 Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.
Q8TF76 HASPIN S185 psp Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
Q8WU20 FRS2 S155 ochoa Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Q8WUB8 PHF10 S36 ochoa PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
Q8WUY3 PRUNE2 S1670 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WWI1 LMO7 S1204 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WYL5 SSH1 S912 ochoa Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
Q8WYP5 AHCTF1 S1297 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92585 MAML1 S168 ochoa Mastermind-like protein 1 (Mam-1) Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Q92608 DOCK2 S1644 ochoa Dedicator of cytokinesis protein 2 Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.
Q92900 UPF1 S203 ochoa Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}.
Q96BY6 DOCK10 S1236 ochoa Dedicator of cytokinesis protein 10 (Zizimin-3) Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.
Q96BY6 DOCK10 S1257 ochoa Dedicator of cytokinesis protein 10 (Zizimin-3) Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.
Q96EX2 RNFT2 S19 ochoa E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118) E3 ubiquitin-protein ligase that negatively regulates IL3-dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect. {ECO:0000269|PubMed:31990690}.
Q96GD3 SCMH1 S509 ochoa Polycomb protein SCMH1 (Sex comb on midleg homolog 1) Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. {ECO:0000250}.
Q96JY6 PDLIM2 S206 ochoa PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
Q96LR2 LURAP1 S129 ochoa Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3, ECO:0000269|PubMed:21048106}.
Q96M96 FGD4 S702 ochoa FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}.
Q96N64 PWWP2A S587 ochoa PWWP domain-containing protein 2A Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}.
Q96PC5 MIA2 S1255 ochoa Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}.
Q96RT6 CTAGE1 S616 ochoa cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) None
Q99755 PIP5K1A S68 ochoa Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}.
Q99755 PIP5K1A S347 ochoa Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}.
Q9BRR9 ARHGAP9 S144 ochoa Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.
Q9BXC1 GPR174 S304 ochoa Probable G-protein coupled receptor 174 G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells. {ECO:0000250|UniProtKB:Q3U507, ECO:0000269|PubMed:36823105}.
Q9C0B5 ZDHHC5 S455 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0C2 TNKS1BP1 S456 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0I1 MTMR12 S601 ochoa Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}.
Q9H4L5 OSBPL3 S164 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H4L5 OSBPL3 S166 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H6S3 EPS8L2 S28 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9H7E9 C8orf33 S39 ochoa UPF0488 protein C8orf33 None
Q9HBD1 RC3H2 S562 ochoa Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}.
Q9HCH5 SYTL2 S390 ochoa Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
Q9HDC5 JPH1 S216 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NP62 GCM1 S275 psp Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}.
Q9NQW6 ANLN S658 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NU19 TBC1D22B S116 ochoa TBC1 domain family member 22B May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q9NUL3 STAU2 S432 ochoa Double-stranded RNA-binding protein Staufen homolog 2 RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}.
Q9NWH9 SLTM S909 ochoa SAFB-like transcription modulator (Modulator of estrogen-induced transcription) When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NYQ7 CELSR3 S3181 ochoa Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9P286 PAK5 S288 psp Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Q9P2G1 ANKIB1 S938 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9P2M4 TBC1D14 S123 ochoa TBC1 domain family member 14 Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}.
Q9P2N2 ARHGAP28 S55 ochoa Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9UBC3 DNMT3B S195 ochoa DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}.
Q9UBW8 COPS7A S255 ochoa COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Q9UH99 SUN2 S136 ochoa SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.
Q9UHB6 LIMA1 S230 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UHV7 MED13 S859 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UKL3 CASP8AP2 S29 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKL3 CASP8AP2 S1537 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9ULH0 KIDINS220 S918 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9ULH0 KIDINS220 S1483 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9Y294 ASF1A S175 ochoa Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}.
Q9Y2W2 WBP11 S604 ochoa WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.
Q9Y3X0 CCDC9 S335 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y4D2 DAGLA S836 ochoa Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}.
Q9Y512 SAMM50 S189 ochoa Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}.
Q9HCC0 MCCC2 S256 Sugiyama Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.
P33993 MCM7 S410 Sugiyama DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
O43283 MAP3K13 S411 Sugiyama Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
P35658 NUP214 S974 Sugiyama Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.
Q13976 PRKG1 S73 Sugiyama cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}.
Q7Z6J9 TSEN54 S189 Sugiyama tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
Q9P0L2 MARK1 S20 Sugiyama Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.
Q8IYP9 ZDHHC23 S200 Sugiyama Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}.
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reactome_id name p -log10_p
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000039 4.413
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000044 4.357
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000044 4.357
R-HSA-1855170 IPs transport between nucleus and cytosol 0.000056 4.250
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.000056 4.250
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.000063 4.198
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.000080 4.099
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.000121 3.916
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.000134 3.873
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.000099 4.006
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.000063 4.198
R-HSA-180746 Nuclear import of Rev protein 0.000071 4.148
R-HSA-6784531 tRNA processing in the nucleus 0.000093 4.034
R-HSA-177243 Interactions of Rev with host cellular proteins 0.000134 3.873
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.000134 3.873
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.000110 3.960
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.000121 3.916
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.000148 3.831
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.000233 3.633
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.000253 3.596
R-HSA-2980766 Nuclear Envelope Breakdown 0.000585 3.232
R-HSA-194441 Metabolism of non-coding RNA 0.000670 3.174
R-HSA-191859 snRNP Assembly 0.000670 3.174
R-HSA-168325 Viral Messenger RNA Synthesis 0.000764 3.117
R-HSA-5578749 Transcriptional regulation by small RNAs 0.001464 2.834
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.001545 2.811
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.001783 2.749
R-HSA-1169408 ISG15 antiviral mechanism 0.001718 2.765
R-HSA-1483249 Inositol phosphate metabolism 0.001826 2.738
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.002410 2.618
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.002433 2.614
R-HSA-162909 Host Interactions of HIV factors 0.003091 2.510
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.004464 2.350
R-HSA-9022707 MECP2 regulates transcription factors 0.004821 2.317
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.005795 2.237
R-HSA-70171 Glycolysis 0.005863 2.232
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.006308 2.200
R-HSA-211000 Gene Silencing by RNA 0.007786 2.109
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 0.009202 2.036
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.010133 1.994
R-HSA-428540 Activation of RAC1 0.010494 1.979
R-HSA-70326 Glucose metabolism 0.011434 1.942
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.011960 1.922
R-HSA-68875 Mitotic Prophase 0.012502 1.903
R-HSA-3371556 Cellular response to heat stress 0.012872 1.890
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.013302 1.876
R-HSA-72306 tRNA processing 0.013424 1.872
R-HSA-418457 cGMP effects 0.014814 1.829
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.014814 1.829
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.014814 1.829
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.016397 1.785
R-HSA-2559583 Cellular Senescence 0.016858 1.773
R-HSA-169893 Prolonged ERK activation events 0.018049 1.744
R-HSA-8986944 Transcriptional Regulation by MECP2 0.019748 1.704
R-HSA-9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction 0.020164 1.695
R-HSA-9609690 HCMV Early Events 0.023539 1.628
R-HSA-68886 M Phase 0.023029 1.638
R-HSA-5688426 Deubiquitination 0.023327 1.632
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.024666 1.608
R-HSA-162599 Late Phase of HIV Life Cycle 0.024666 1.608
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.025315 1.597
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.029322 1.533
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.031414 1.503
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.034133 1.467
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.031414 1.503
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.032885 1.483
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.032199 1.492
R-HSA-9610379 HCMV Late Events 0.034284 1.465
R-HSA-162587 HIV Life Cycle 0.034284 1.465
R-HSA-376172 DSCAM interactions 0.039924 1.399
R-HSA-9620244 Long-term potentiation 0.040341 1.394
R-HSA-9932451 SWI/SNF chromatin remodelers 0.040341 1.394
R-HSA-9932444 ATP-dependent chromatin remodelers 0.040341 1.394
R-HSA-9707616 Heme signaling 0.035382 1.451
R-HSA-69278 Cell Cycle, Mitotic 0.038725 1.412
R-HSA-1640170 Cell Cycle 0.036324 1.440
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes 0.038028 1.420
R-HSA-9830364 Formation of the nephric duct 0.040341 1.394
R-HSA-9694516 SARS-CoV-2 Infection 0.036186 1.441
R-HSA-162906 HIV Infection 0.041769 1.379
R-HSA-5619102 SLC transporter disorders 0.041829 1.379
R-HSA-9705683 SARS-CoV-2-host interactions 0.042450 1.372
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.042705 1.370
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.042705 1.370
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.045120 1.346
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.045120 1.346
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.047585 1.323
R-HSA-9909438 3-Methylcrotonyl-CoA carboxylase deficiency 0.049655 1.304
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.050098 1.300
R-HSA-8875513 MET interacts with TNS proteins 0.049655 1.304
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.059288 1.227
R-HSA-9609646 HCMV Infection 0.059225 1.227
R-HSA-168255 Influenza Infection 0.053030 1.275
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.057912 1.237
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.060605 1.217
R-HSA-9733709 Cardiogenesis 0.060605 1.217
R-HSA-5675482 Regulation of necroptotic cell death 0.060605 1.217
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.061741 1.209
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.063341 1.198
R-HSA-111957 Cam-PDE 1 activation 0.078263 1.106
R-HSA-170984 ARMS-mediated activation 0.115081 0.939
R-HSA-4839744 Signaling by APC mutants 0.132937 0.876
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.132937 0.876
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.132937 0.876
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.132937 0.876
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.141731 0.849
R-HSA-5339716 Signaling by GSK3beta mutants 0.141731 0.849
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.150436 0.823
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.150436 0.823
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.150436 0.823
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.150436 0.823
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.150436 0.823
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.150436 0.823
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.159053 0.798
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.159053 0.798
R-HSA-196299 Beta-catenin phosphorylation cascade 0.176028 0.754
R-HSA-176412 Phosphorylation of the APC/C 0.184387 0.734
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.184387 0.734
R-HSA-5083636 Defective GALNT12 causes CRCS1 0.184387 0.734
R-HSA-212300 PRC2 methylates histones and DNA 0.071789 1.144
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.216989 0.664
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.216989 0.664
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.224935 0.648
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.224935 0.648
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.224935 0.648
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.224935 0.648
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.224935 0.648
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.232801 0.633
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.240588 0.619
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.111989 0.951
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.270956 0.567
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.300118 0.523
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.248504 0.605
R-HSA-141424 Amplification of signal from the kinetochores 0.248504 0.605
R-HSA-8878166 Transcriptional regulation by RUNX2 0.154987 0.810
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.307225 0.513
R-HSA-8941326 RUNX2 regulates bone development 0.071789 1.144
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.232801 0.633
R-HSA-68962 Activation of the pre-replicative complex 0.307225 0.513
R-HSA-2467813 Separation of Sister Chromatids 0.116379 0.934
R-HSA-5654710 PI-3K cascade:FGFR3 0.216989 0.664
R-HSA-5654720 PI-3K cascade:FGFR4 0.224935 0.648
R-HSA-5654689 PI-3K cascade:FGFR1 0.248296 0.605
R-HSA-5654695 PI-3K cascade:FGFR2 0.270956 0.567
R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.078263 1.106
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.141731 0.849
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.240588 0.619
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.248296 0.605
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.270956 0.567
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.292938 0.533
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.192662 0.715
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.150436 0.823
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 0.150436 0.823
R-HSA-69618 Mitotic Spindle Checkpoint 0.105174 0.978
R-HSA-8963901 Chylomicron remodeling 0.159053 0.798
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.200853 0.697
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.307225 0.513
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.278358 0.555
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.086613 1.062
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.086631 1.062
R-HSA-5654708 Downstream signaling of activated FGFR3 0.300118 0.523
R-HSA-5654716 Downstream signaling of activated FGFR4 0.307225 0.513
R-HSA-4791275 Signaling by WNT in cancer 0.321225 0.493
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.160085 0.796
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.089680 1.047
R-HSA-9032845 Activated NTRK2 signals through CDK5 0.096858 1.014
R-HSA-2470946 Cohesin Loading onto Chromatin 0.096858 1.014
R-HSA-176974 Unwinding of DNA 0.115081 0.939
R-HSA-4839735 Signaling by AXIN mutants 0.141731 0.849
R-HSA-4839748 Signaling by AMER1 mutants 0.141731 0.849
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.192662 0.715
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.208962 0.680
R-HSA-350054 Notch-HLH transcription pathway 0.248296 0.605
R-HSA-8949613 Cristae formation 0.285685 0.544
R-HSA-5655291 Signaling by FGFR4 in disease 0.167584 0.776
R-HSA-68882 Mitotic Anaphase 0.094825 1.023
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.176028 0.754
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.248296 0.605
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.096103 1.017
R-HSA-170968 Frs2-mediated activation 0.159053 0.798
R-HSA-8849932 Synaptic adhesion-like molecules 0.208962 0.680
R-HSA-68867 Assembly of the pre-replicative complex 0.282316 0.549
R-HSA-75893 TNF signaling 0.139001 0.857
R-HSA-187687 Signalling to ERKs 0.068934 1.162
R-HSA-5357905 Regulation of TNFR1 signaling 0.105474 0.977
R-HSA-426048 Arachidonate production from DAG 0.124054 0.906
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.192662 0.715
R-HSA-9710421 Defective pyroptosis 0.095909 1.018
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.232801 0.633
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.263479 0.579
R-HSA-420029 Tight junction interactions 0.270956 0.567
R-HSA-5655332 Signaling by FGFR3 in disease 0.285685 0.544
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.307225 0.513
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.319730 0.495
R-HSA-69052 Switching of origins to a post-replicative state 0.200039 0.699
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.115081 0.939
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.285685 0.544
R-HSA-5334118 DNA methylation 0.300118 0.523
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.174450 0.758
R-HSA-9909396 Circadian clock 0.065689 1.183
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 0.096858 1.014
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.141731 0.849
R-HSA-1475029 Reversible hydration of carbon dioxide 0.159053 0.798
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.184387 0.734
R-HSA-429947 Deadenylation of mRNA 0.263479 0.579
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.278358 0.555
R-HSA-5694530 Cargo concentration in the ER 0.314261 0.503
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.237254 0.625
R-HSA-6794362 Protein-protein interactions at synapses 0.244752 0.611
R-HSA-196780 Biotin transport and metabolism 0.176028 0.754
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.270956 0.567
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.292938 0.533
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.300118 0.523
R-HSA-164944 Nef and signal transduction 0.087608 1.057
R-HSA-8963888 Chylomicron assembly 0.132937 0.876
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 0.132937 0.876
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.176028 0.754
R-HSA-9675126 Diseases of mitotic cell cycle 0.321225 0.493
R-HSA-1500620 Meiosis 0.244752 0.611
R-HSA-3214841 PKMTs methylate histone lysines 0.086613 1.062
R-HSA-73887 Death Receptor Signaling 0.100033 1.000
R-HSA-2559580 Oxidative Stress Induced Senescence 0.109403 0.961
R-HSA-3323169 Defects in biotin (Btn) metabolism 0.115081 0.939
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.184387 0.734
R-HSA-5689901 Metalloprotease DUBs 0.278358 0.555
R-HSA-69620 Cell Cycle Checkpoints 0.155611 0.808
R-HSA-392517 Rap1 signalling 0.216989 0.664
R-HSA-198753 ERK/MAPK targets 0.232801 0.633
R-HSA-193648 NRAGE signals death through JNK 0.139001 0.857
R-HSA-525793 Myogenesis 0.278358 0.555
R-HSA-4839726 Chromatin organization 0.294166 0.531
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.271046 0.567
R-HSA-74160 Gene expression (Transcription) 0.217804 0.662
R-HSA-8943724 Regulation of PTEN gene transcription 0.152990 0.815
R-HSA-69190 DNA strand elongation 0.321225 0.493
R-HSA-8963899 Plasma lipoprotein remodeling 0.111989 0.951
R-HSA-438064 Post NMDA receptor activation events 0.256015 0.592
R-HSA-166520 Signaling by NTRKs 0.090780 1.042
R-HSA-1989781 PPARA activates gene expression 0.258855 0.587
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.179682 0.745
R-HSA-8878171 Transcriptional regulation by RUNX1 0.107993 0.967
R-HSA-9683610 Maturation of nucleoprotein 0.159053 0.798
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.264316 0.578
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.137421 0.862
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 0.278358 0.555
R-HSA-1483255 PI Metabolism 0.319730 0.495
R-HSA-162582 Signal Transduction 0.186411 0.730
R-HSA-8964058 HDL remodeling 0.216989 0.664
R-HSA-597592 Post-translational protein modification 0.132333 0.878
R-HSA-5689880 Ub-specific processing proteases 0.133812 0.874
R-HSA-9694631 Maturation of nucleoprotein 0.216989 0.664
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.248296 0.605
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.077612 1.110
R-HSA-416482 G alpha (12/13) signalling events 0.218576 0.660
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.300118 0.523
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.200039 0.699
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.278560 0.555
R-HSA-2262752 Cellular responses to stress 0.174572 0.758
R-HSA-168638 NOD1/2 Signaling Pathway 0.066117 1.180
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.192662 0.715
R-HSA-1834941 STING mediated induction of host immune responses 0.216989 0.664
R-HSA-8963898 Plasma lipoprotein assembly 0.263479 0.579
R-HSA-9006925 Intracellular signaling by second messengers 0.309527 0.509
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.255926 0.592
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.145960 0.836
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.241001 0.618
R-HSA-8953897 Cellular responses to stimuli 0.300800 0.522
R-HSA-9694635 Translation of Structural Proteins 0.214855 0.668
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.169609 0.771
R-HSA-5218859 Regulated Necrosis 0.181708 0.741
R-HSA-75153 Apoptotic execution phase 0.105474 0.977
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.214855 0.668
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.278560 0.555
R-HSA-9645723 Diseases of programmed cell death 0.259772 0.585
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.090780 1.042
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.129213 0.889
R-HSA-166166 MyD88-independent TLR4 cascade 0.129213 0.889
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.118054 0.928
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.167240 0.777
R-HSA-9830369 Kidney development 0.178073 0.749
R-HSA-193704 p75 NTR receptor-mediated signalling 0.308542 0.511
R-HSA-9679506 SARS-CoV Infections 0.235004 0.629
R-HSA-168898 Toll-like Receptor Cascades 0.167645 0.776
R-HSA-5619115 Disorders of transmembrane transporters 0.138352 0.859
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.327165 0.485
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.328120 0.484
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.328120 0.484
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.328120 0.484
R-HSA-176187 Activation of ATR in response to replication stress 0.328120 0.484
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.328120 0.484
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.328120 0.484
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.330875 0.480
R-HSA-5619507 Activation of HOX genes during differentiation 0.330875 0.480
R-HSA-5696398 Nucleotide Excision Repair 0.334579 0.476
R-HSA-5693537 Resolution of D-Loop Structures 0.334944 0.475
R-HSA-114508 Effects of PIP2 hydrolysis 0.334944 0.475
R-HSA-212436 Generic Transcription Pathway 0.337622 0.472
R-HSA-418346 Platelet homeostasis 0.338277 0.471
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.341700 0.466
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.341700 0.466
R-HSA-1980145 Signaling by NOTCH2 0.341700 0.466
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.341700 0.466
R-HSA-69239 Synthesis of DNA 0.341969 0.466
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.341969 0.466
R-HSA-9700206 Signaling by ALK in cancer 0.341969 0.466
R-HSA-5654696 Downstream signaling of activated FGFR2 0.348387 0.458
R-HSA-5654687 Downstream signaling of activated FGFR1 0.348387 0.458
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.348387 0.458
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.348387 0.458
R-HSA-3296482 Defects in vitamin and cofactor metabolism 0.348387 0.458
R-HSA-69002 DNA Replication Pre-Initiation 0.349334 0.457
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.349334 0.457
R-HSA-9682385 FLT3 signaling in disease 0.355007 0.450
R-HSA-111933 Calmodulin induced events 0.355007 0.450
R-HSA-111997 CaM pathway 0.355007 0.450
R-HSA-8853659 RET signaling 0.355007 0.450
R-HSA-4641258 Degradation of DVL 0.361561 0.442
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.361561 0.442
R-HSA-5689896 Ovarian tumor domain proteases 0.361561 0.442
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.363980 0.439
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.368048 0.434
R-HSA-8875878 MET promotes cell motility 0.368048 0.434
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.368048 0.434
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.369877 0.432
R-HSA-201556 Signaling by ALK 0.374469 0.427
R-HSA-8953750 Transcriptional Regulation by E2F6 0.374469 0.427
R-HSA-1592230 Mitochondrial biogenesis 0.385710 0.414
R-HSA-9694548 Maturation of spike protein 0.387118 0.412
R-HSA-8853884 Transcriptional Regulation by VENTX 0.387118 0.412
R-HSA-3000480 Scavenging by Class A Receptors 0.393347 0.405
R-HSA-5655302 Signaling by FGFR1 in disease 0.393347 0.405
R-HSA-6811438 Intra-Golgi traffic 0.393347 0.405
R-HSA-9683701 Translation of Structural Proteins 0.393347 0.405
R-HSA-913531 Interferon Signaling 0.393798 0.405
R-HSA-111996 Ca-dependent events 0.399513 0.398
R-HSA-1257604 PIP3 activates AKT signaling 0.399735 0.398
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.400019 0.398
R-HSA-5357801 Programmed Cell Death 0.402248 0.396
R-HSA-5654743 Signaling by FGFR4 0.405617 0.392
R-HSA-8854214 TBC/RABGAPs 0.405617 0.392
R-HSA-195721 Signaling by WNT 0.406598 0.391
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.407116 0.390
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.407116 0.390
R-HSA-3214858 RMTs methylate histone arginines 0.411658 0.385
R-HSA-3928662 EPHB-mediated forward signaling 0.411658 0.385
R-HSA-373752 Netrin-1 signaling 0.411658 0.385
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.411658 0.385
R-HSA-5654741 Signaling by FGFR3 0.417639 0.379
R-HSA-4608870 Asymmetric localization of PCP proteins 0.417639 0.379
R-HSA-1489509 DAG and IP3 signaling 0.417639 0.379
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.417639 0.379
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.417685 0.379
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.417685 0.379
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.417685 0.379
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.423560 0.373
R-HSA-9675135 Diseases of DNA repair 0.423560 0.373
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.423560 0.373
R-HSA-69481 G2/M Checkpoints 0.424679 0.372
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.429421 0.367
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.429421 0.367
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.435088 0.361
R-HSA-5620924 Intraflagellar transport 0.435222 0.361
R-HSA-1474165 Reproduction 0.438535 0.358
R-HSA-1280215 Cytokine Signaling in Immune system 0.439468 0.357
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.440965 0.356
R-HSA-5655253 Signaling by FGFR2 in disease 0.446650 0.350
R-HSA-109704 PI3K Cascade 0.446650 0.350
R-HSA-912446 Meiotic recombination 0.452277 0.345
R-HSA-70895 Branched-chain amino acid catabolism 0.452277 0.345
R-HSA-1852241 Organelle biogenesis and maintenance 0.456368 0.341
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.457847 0.339
R-HSA-68949 Orc1 removal from chromatin 0.457847 0.339
R-HSA-6794361 Neurexins and neuroligins 0.457847 0.339
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.457847 0.339
R-HSA-3858494 Beta-catenin independent WNT signaling 0.462341 0.335
R-HSA-212165 Epigenetic regulation of gene expression 0.463058 0.334
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.463361 0.334
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.463361 0.334
R-HSA-1221632 Meiotic synapsis 0.463361 0.334
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.468820 0.329
R-HSA-6807070 PTEN Regulation 0.472364 0.326
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.474223 0.324
R-HSA-9012852 Signaling by NOTCH3 0.474223 0.324
R-HSA-3247509 Chromatin modifying enzymes 0.479438 0.319
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.479571 0.319
R-HSA-5654736 Signaling by FGFR1 0.479571 0.319
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.479571 0.319
R-HSA-73857 RNA Polymerase II Transcription 0.483266 0.316
R-HSA-112399 IRS-mediated signalling 0.484866 0.314
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.484866 0.314
R-HSA-8856828 Clathrin-mediated endocytosis 0.488818 0.311
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.495295 0.305
R-HSA-429914 Deadenylation-dependent mRNA decay 0.495295 0.305
R-HSA-186712 Regulation of beta-cell development 0.495295 0.305
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.500430 0.301
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.500430 0.301
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.500430 0.301
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.500430 0.301
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.500430 0.301
R-HSA-983189 Kinesins 0.500430 0.301
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.500430 0.301
R-HSA-199977 ER to Golgi Anterograde Transport 0.501750 0.300
R-HSA-69242 S Phase 0.504950 0.297
R-HSA-2428928 IRS-related events triggered by IGF1R 0.505514 0.296
R-HSA-9793380 Formation of paraxial mesoderm 0.505514 0.296
R-HSA-112043 PLC beta mediated events 0.505514 0.296
R-HSA-211976 Endogenous sterols 0.505514 0.296
R-HSA-450294 MAP kinase activation 0.505514 0.296
R-HSA-8953854 Metabolism of RNA 0.509296 0.293
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.510546 0.292
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.510546 0.292
R-HSA-1268020 Mitochondrial protein import 0.510546 0.292
R-HSA-936837 Ion transport by P-type ATPases 0.520458 0.284
R-HSA-2428924 IGF1R signaling cascade 0.520458 0.284
R-HSA-211981 Xenobiotics 0.520458 0.284
R-HSA-74751 Insulin receptor signalling cascade 0.520458 0.284
R-HSA-5693532 DNA Double-Strand Break Repair 0.520752 0.283
R-HSA-69306 DNA Replication 0.520752 0.283
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.523872 0.281
R-HSA-199991 Membrane Trafficking 0.524769 0.280
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.525339 0.280
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.534705 0.272
R-HSA-5693606 DNA Double Strand Break Response 0.534953 0.272
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.534953 0.272
R-HSA-112040 G-protein mediated events 0.534953 0.272
R-HSA-196807 Nicotinate metabolism 0.534953 0.272
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.539687 0.268
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.539687 0.268
R-HSA-913709 O-linked glycosylation of mucins 0.539687 0.268
R-HSA-73894 DNA Repair 0.542841 0.265
R-HSA-109581 Apoptosis 0.548341 0.261
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.549013 0.260
R-HSA-204005 COPII-mediated vesicle transport 0.549013 0.260
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.549013 0.260
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.549013 0.260
R-HSA-448424 Interleukin-17 signaling 0.549013 0.260
R-HSA-453276 Regulation of mitotic cell cycle 0.553605 0.257
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.553605 0.257
R-HSA-427413 NoRC negatively regulates rRNA expression 0.553605 0.257
R-HSA-975634 Retinoid metabolism and transport 0.553605 0.257
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.553605 0.257
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.558150 0.253
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.558150 0.253
R-HSA-4086398 Ca2+ pathway 0.562650 0.250
R-HSA-9013694 Signaling by NOTCH4 0.567104 0.246
R-HSA-1226099 Signaling by FGFR in disease 0.567104 0.246
R-HSA-69473 G2/M DNA damage checkpoint 0.567104 0.246
R-HSA-8852135 Protein ubiquitination 0.571513 0.243
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.571513 0.243
R-HSA-1980143 Signaling by NOTCH1 0.575877 0.240
R-HSA-5689603 UCH proteinases 0.575877 0.240
R-HSA-109582 Hemostasis 0.578575 0.238
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.580534 0.236
R-HSA-383280 Nuclear Receptor transcription pathway 0.584473 0.233
R-HSA-216083 Integrin cell surface interactions 0.584473 0.233
R-HSA-4086400 PCP/CE pathway 0.584473 0.233
R-HSA-9659379 Sensory processing of sound 0.588707 0.230
R-HSA-9678108 SARS-CoV-1 Infection 0.589019 0.230
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.591264 0.228
R-HSA-5654738 Signaling by FGFR2 0.592897 0.227
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.592897 0.227
R-HSA-6806834 Signaling by MET 0.592897 0.227
R-HSA-5693607 Processing of DNA double-strand break ends 0.597044 0.224
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.597044 0.224
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.597044 0.224
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.601150 0.221
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.609237 0.215
R-HSA-201681 TCF dependent signaling in response to WNT 0.611024 0.214
R-HSA-5653656 Vesicle-mediated transport 0.611981 0.213
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.621064 0.207
R-HSA-9824446 Viral Infection Pathways 0.626574 0.203
R-HSA-5617833 Cilium Assembly 0.629539 0.201
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.636280 0.196
R-HSA-112310 Neurotransmitter release cycle 0.636280 0.196
R-HSA-68877 Mitotic Prometaphase 0.637262 0.196
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.639932 0.194
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.643659 0.191
R-HSA-2682334 EPH-Ephrin signaling 0.647293 0.189
R-HSA-74752 Signaling by Insulin receptor 0.647293 0.189
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.654450 0.184
R-HSA-389948 Co-inhibition by PD-1 0.654796 0.184
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.654796 0.184
R-HSA-948021 Transport to the Golgi and subsequent modification 0.659681 0.181
R-HSA-376176 Signaling by ROBO receptors 0.662102 0.179
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.664915 0.177
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.664915 0.177
R-HSA-8878159 Transcriptional regulation by RUNX3 0.668333 0.175
R-HSA-190236 Signaling by FGFR 0.671717 0.173
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.671717 0.173
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.671717 0.173
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.671717 0.173
R-HSA-192105 Synthesis of bile acids and bile salts 0.675066 0.171
R-HSA-112315 Transmission across Chemical Synapses 0.680886 0.167
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.685568 0.164
R-HSA-422475 Axon guidance 0.686730 0.163
R-HSA-111885 Opioid Signalling 0.691308 0.160
R-HSA-9833110 RSV-host interactions 0.694459 0.158
R-HSA-9692914 SARS-CoV-1-host interactions 0.700664 0.154
R-HSA-8951664 Neddylation 0.705537 0.151
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.706744 0.151
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.709738 0.149
R-HSA-194068 Bile acid and bile salt metabolism 0.712701 0.147
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.718538 0.144
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.718538 0.144
R-HSA-6798695 Neutrophil degranulation 0.720136 0.143
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.721412 0.142
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.724257 0.140
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.724446 0.140
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.729860 0.137
R-HSA-9007101 Rab regulation of trafficking 0.738054 0.132
R-HSA-9675108 Nervous system development 0.738610 0.132
R-HSA-5693538 Homology Directed Repair 0.740730 0.130
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.740730 0.130
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.743379 0.129
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.743379 0.129
R-HSA-157118 Signaling by NOTCH 0.744250 0.128
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.751165 0.124
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.751165 0.124
R-HSA-196854 Metabolism of vitamins and cofactors 0.752062 0.124
R-HSA-392499 Metabolism of proteins 0.756700 0.121
R-HSA-69206 G1/S Transition 0.761182 0.119
R-HSA-421270 Cell-cell junction organization 0.764624 0.117
R-HSA-388841 Regulation of T cell activation by CD28 family 0.773413 0.112
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.777069 0.110
R-HSA-9843745 Adipogenesis 0.777758 0.109
R-HSA-8856688 Golgi-to-ER retrograde transport 0.780030 0.108
R-HSA-1474228 Degradation of the extracellular matrix 0.780030 0.108
R-HSA-449147 Signaling by Interleukins 0.790752 0.102
R-HSA-5173105 O-linked glycosylation 0.793189 0.101
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.793189 0.101
R-HSA-446728 Cell junction organization 0.808777 0.092
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.813404 0.090
R-HSA-2187338 Visual phototransduction 0.815314 0.089
R-HSA-9758941 Gastrulation 0.819077 0.087
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.820929 0.086
R-HSA-9856651 MITF-M-dependent gene expression 0.820929 0.086
R-HSA-5673001 RAF/MAP kinase cascade 0.824560 0.084
R-HSA-9609507 Protein localization 0.826374 0.083
R-HSA-1483257 Phospholipid metabolism 0.832669 0.080
R-HSA-5684996 MAPK1/MAPK3 signaling 0.833988 0.079
R-HSA-5633007 Regulation of TP53 Activity 0.838447 0.077
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.849686 0.071
R-HSA-1280218 Adaptive Immune System 0.856880 0.067
R-HSA-418555 G alpha (s) signalling events 0.857234 0.067
R-HSA-1500931 Cell-Cell communication 0.858469 0.066
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.860147 0.065
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.860147 0.065
R-HSA-1266738 Developmental Biology 0.862220 0.064
R-HSA-1474244 Extracellular matrix organization 0.874627 0.058
R-HSA-3781865 Diseases of glycosylation 0.875143 0.058
R-HSA-112316 Neuronal System 0.877553 0.057
R-HSA-69275 G2/M Transition 0.877692 0.057
R-HSA-453274 Mitotic G2-G2/M phases 0.880190 0.055
R-HSA-983712 Ion channel transport 0.881420 0.055
R-HSA-72163 mRNA Splicing - Major Pathway 0.887383 0.052
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.889684 0.051
R-HSA-5683057 MAPK family signaling cascades 0.889987 0.051
R-HSA-168256 Immune System 0.892433 0.049
R-HSA-72172 mRNA Splicing 0.899473 0.046
R-HSA-9006931 Signaling by Nuclear Receptors 0.903596 0.044
R-HSA-9730414 MITF-M-regulated melanocyte development 0.908399 0.042
R-HSA-418990 Adherens junctions interactions 0.913012 0.040
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.922365 0.035
R-HSA-202733 Cell surface interactions at the vascular wall 0.928532 0.032
R-HSA-446203 Asparagine N-linked glycosylation 0.941875 0.026
R-HSA-5668914 Diseases of metabolism 0.944314 0.025
R-HSA-416476 G alpha (q) signalling events 0.945969 0.024
R-HSA-76002 Platelet activation, signaling and aggregation 0.951291 0.022
R-HSA-211945 Phase I - Functionalization of compounds 0.953271 0.021
R-HSA-3700989 Transcriptional Regulation by TP53 0.959924 0.018
R-HSA-388396 GPCR downstream signalling 0.963672 0.016
R-HSA-1643685 Disease 0.964553 0.016
R-HSA-5663205 Infectious disease 0.967521 0.014
R-HSA-168249 Innate Immune System 0.969232 0.014
R-HSA-8957322 Metabolism of steroids 0.971028 0.013
R-HSA-372790 Signaling by GPCR 0.980367 0.009
R-HSA-425407 SLC-mediated transmembrane transport 0.986611 0.006
R-HSA-418594 G alpha (i) signalling events 0.987941 0.005
R-HSA-382551 Transport of small molecules 0.992521 0.003
R-HSA-211859 Biological oxidations 0.996433 0.002
R-HSA-556833 Metabolism of lipids 0.998502 0.001
R-HSA-71291 Metabolism of amino acids and derivatives 0.998694 0.001
R-HSA-9709957 Sensory Perception 0.999976 0.000
R-HSA-1430728 Metabolism 0.999998 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
NDR2NDR2 0.869 0.335 -3 0.869
PIM3PIM3 0.867 0.376 -3 0.904
RSK2RSK2 0.866 0.404 -3 0.903
PIM1PIM1 0.865 0.429 -3 0.911
P90RSKP90RSK 0.863 0.402 -3 0.914
SIKSIK 0.861 0.505 -3 0.870
MAPKAPK2MAPKAPK2 0.861 0.410 -3 0.876
CAMK2ACAMK2A 0.861 0.422 2 0.828
PRKD2PRKD2 0.860 0.362 -3 0.864
MARK4MARK4 0.860 0.434 4 0.869
QSKQSK 0.860 0.493 4 0.864
LATS2LATS2 0.859 0.305 -5 0.772
CAMK2BCAMK2B 0.859 0.375 2 0.796
RSK3RSK3 0.859 0.372 -3 0.901
PRKD1PRKD1 0.858 0.315 -3 0.858
NUAK2NUAK2 0.858 0.371 -3 0.890
CAMK2DCAMK2D 0.857 0.353 -3 0.847
CAMK1BCAMK1B 0.857 0.386 -3 0.885
COTCOT 0.857 0.072 2 0.776
NDR1NDR1 0.857 0.298 -3 0.883
CDKL1CDKL1 0.857 0.392 -3 0.910
AMPKA1AMPKA1 0.855 0.406 -3 0.869
MSK2MSK2 0.855 0.377 -3 0.903
MARK3MARK3 0.855 0.491 4 0.889
MARK2MARK2 0.855 0.497 4 0.860
MSK1MSK1 0.855 0.379 -3 0.900
MAPKAPK3MAPKAPK3 0.855 0.365 -3 0.870
CLK3CLK3 0.854 0.235 1 0.787
AMPKA2AMPKA2 0.854 0.413 -3 0.873
RSK4RSK4 0.854 0.384 -3 0.898
BRSK1BRSK1 0.853 0.412 -3 0.882
CDC7CDC7 0.853 0.101 1 0.822
SRPK2SRPK2 0.852 0.360 -3 0.891
SRPK1SRPK1 0.852 0.329 -3 0.911
CDKL5CDKL5 0.852 0.333 -3 0.910
PKN3PKN3 0.851 0.271 -3 0.882
PKACGPKACG 0.851 0.275 -2 0.831
PRKXPRKX 0.851 0.378 -3 0.858
NUAK1NUAK1 0.850 0.371 -3 0.884
SKMLCKSKMLCK 0.850 0.277 -2 0.915
MARK1MARK1 0.850 0.465 4 0.870
TSSK1TSSK1 0.849 0.351 -3 0.865
P70S6KBP70S6KB 0.849 0.314 -3 0.898
PKACBPKACB 0.848 0.330 -2 0.764
CAMK2GCAMK2G 0.847 0.153 2 0.809
ICKICK 0.847 0.319 -3 0.901
HIPK4HIPK4 0.847 0.264 1 0.754
RAF1RAF1 0.847 0.106 1 0.853
PRKD3PRKD3 0.845 0.350 -3 0.873
IKKBIKKB 0.845 0.039 -2 0.814
MOSMOS 0.844 0.072 1 0.845
CAMLCKCAMLCK 0.844 0.273 -2 0.923
TBK1TBK1 0.844 0.030 1 0.779
CLK4CLK4 0.844 0.317 -3 0.913
QIKQIK 0.844 0.340 -3 0.840
BRSK2BRSK2 0.843 0.324 -3 0.857
MELKMELK 0.843 0.327 -3 0.867
DAPK2DAPK2 0.843 0.304 -3 0.872
MYLK4MYLK4 0.843 0.309 -2 0.854
CAMK1GCAMK1G 0.843 0.371 -3 0.886
CAMK1DCAMK1D 0.843 0.418 -3 0.867
SRPK3SRPK3 0.842 0.307 -3 0.900
PKCDPKCD 0.842 0.207 2 0.701
LATS1LATS1 0.842 0.270 -3 0.867
PKN2PKN2 0.842 0.199 -3 0.860
MTORMTOR 0.842 -0.007 1 0.785
CAMK4CAMK4 0.841 0.230 -3 0.860
PIM2PIM2 0.841 0.365 -3 0.896
NIKNIK 0.841 0.233 -3 0.847
AKT2AKT2 0.841 0.370 -3 0.883
PRPKPRPK 0.840 -0.071 -1 0.879
TSSK2TSSK2 0.840 0.257 -5 0.845
GCN2GCN2 0.840 -0.060 2 0.728
IKKEIKKE 0.840 0.007 1 0.776
PDHK4PDHK4 0.840 -0.069 1 0.853
CLK2CLK2 0.840 0.318 -3 0.911
AURCAURC 0.840 0.188 -2 0.748
WNK1WNK1 0.839 0.134 -2 0.919
PKACAPKACA 0.839 0.333 -2 0.718
NLKNLK 0.839 0.049 1 0.808
ATRATR 0.838 0.052 1 0.805
CLK1CLK1 0.838 0.302 -3 0.883
NIM1NIM1 0.838 0.200 3 0.779
MST4MST4 0.838 0.084 2 0.753
SGK3SGK3 0.837 0.317 -3 0.880
HUNKHUNK 0.837 0.063 2 0.696
BCKDKBCKDK 0.836 0.024 -1 0.850
MAPKAPK5MAPKAPK5 0.836 0.316 -3 0.876
GRK6GRK6 0.836 0.082 1 0.834
TGFBR2TGFBR2 0.834 0.029 -2 0.845
BMPR2BMPR2 0.834 -0.065 -2 0.937
CHK1CHK1 0.834 0.251 -3 0.836
DYRK2DYRK2 0.833 0.174 1 0.674
DSTYKDSTYK 0.833 -0.075 2 0.795
PDHK1PDHK1 0.833 -0.079 1 0.844
AURBAURB 0.833 0.181 -2 0.748
ERK5ERK5 0.833 0.026 1 0.813
P70S6KP70S6K 0.832 0.325 -3 0.878
IKKAIKKA 0.832 0.004 -2 0.794
PKG2PKG2 0.832 0.226 -2 0.762
DCAMKL1DCAMKL1 0.832 0.306 -3 0.872
RIPK3RIPK3 0.832 -0.025 3 0.716
WNK3WNK3 0.832 0.026 1 0.821
GRK1GRK1 0.832 0.059 -2 0.831
PAK1PAK1 0.831 0.158 -2 0.854
PHKG1PHKG1 0.831 0.173 -3 0.870
CAMK1ACAMK1A 0.831 0.416 -3 0.842
ATMATM 0.831 0.065 1 0.739
AKT1AKT1 0.830 0.335 -3 0.877
MASTLMASTL 0.830 -0.041 -2 0.888
ULK2ULK2 0.830 -0.155 2 0.684
GRK5GRK5 0.830 -0.069 -3 0.764
PKCBPKCB 0.829 0.143 2 0.644
AURAAURA 0.829 0.171 -2 0.719
DYRK1ADYRK1A 0.829 0.261 1 0.699
SGK1SGK1 0.828 0.393 -3 0.857
PAK3PAK3 0.828 0.129 -2 0.861
DLKDLK 0.828 0.041 1 0.834
SBKSBK 0.827 0.423 -3 0.819
PKCAPKCA 0.827 0.108 2 0.634
PKCGPKCG 0.827 0.108 2 0.640
HIPK1HIPK1 0.826 0.223 1 0.688
SSTKSSTK 0.826 0.294 4 0.817
SMMLCKSMMLCK 0.826 0.299 -3 0.884
RIPK1RIPK1 0.826 0.003 1 0.820
HIPK2HIPK2 0.826 0.189 1 0.578
FAM20CFAM20C 0.826 0.039 2 0.567
MNK2MNK2 0.826 0.113 -2 0.875
MLK1MLK1 0.825 -0.104 2 0.715
NEK7NEK7 0.825 -0.139 -3 0.731
CHK2CHK2 0.825 0.378 -3 0.846
PASKPASK 0.825 0.293 -3 0.878
PAK2PAK2 0.825 0.142 -2 0.848
DNAPKDNAPK 0.825 0.107 1 0.709
PKCHPKCH 0.824 0.124 2 0.627
DYRK3DYRK3 0.824 0.262 1 0.695
AKT3AKT3 0.823 0.358 -3 0.857
MNK1MNK1 0.823 0.123 -2 0.884
ANKRD3ANKRD3 0.822 -0.039 1 0.867
TGFBR1TGFBR1 0.822 0.057 -2 0.846
SNRKSNRK 0.822 0.127 2 0.579
DCAMKL2DCAMKL2 0.821 0.215 -3 0.870
MEK1MEK1 0.821 0.023 2 0.752
DYRK4DYRK4 0.821 0.157 1 0.593
NEK9NEK9 0.821 -0.133 2 0.730
BMPR1BBMPR1B 0.821 0.079 1 0.797
PKCZPKCZ 0.821 0.071 2 0.671
GRK4GRK4 0.821 -0.071 -2 0.856
PLK3PLK3 0.820 0.019 2 0.703
DAPK3DAPK3 0.820 0.311 -3 0.895
NEK6NEK6 0.820 -0.140 -2 0.896
KISKIS 0.820 -0.016 1 0.657
PLK1PLK1 0.820 -0.024 -2 0.862
CHAK2CHAK2 0.819 -0.101 -1 0.869
MRCKAMRCKA 0.819 0.315 -3 0.881
ULK1ULK1 0.819 -0.183 -3 0.704
DYRK1BDYRK1B 0.818 0.170 1 0.631
PAK6PAK6 0.818 0.102 -2 0.798
ALK4ALK4 0.818 0.002 -2 0.871
PKRPKR 0.818 0.007 1 0.839
HIPK3HIPK3 0.817 0.187 1 0.692
MLK2MLK2 0.817 -0.129 2 0.719
DAPK1DAPK1 0.817 0.299 -3 0.899
PHKG2PHKG2 0.817 0.166 -3 0.845
YSK4YSK4 0.817 -0.051 1 0.793
DRAK1DRAK1 0.816 0.052 1 0.799
CDK8CDK8 0.816 -0.025 1 0.634
IRE1IRE1 0.816 -0.067 1 0.792
CDK7CDK7 0.816 0.002 1 0.638
PKCTPKCT 0.816 0.154 2 0.635
PKN1PKN1 0.815 0.266 -3 0.871
GRK7GRK7 0.815 0.038 1 0.753
MRCKBMRCKB 0.815 0.308 -3 0.875
IRE2IRE2 0.814 -0.041 2 0.648
ROCK2ROCK2 0.814 0.307 -3 0.887
SMG1SMG1 0.813 -0.027 1 0.756
ALK2ALK2 0.813 0.033 -2 0.852
ACVR2AACVR2A 0.812 0.017 -2 0.839
NEK2NEK2 0.812 -0.083 2 0.702
MLK3MLK3 0.811 -0.098 2 0.651
TTBK2TTBK2 0.811 -0.158 2 0.590
TLK2TLK2 0.811 -0.044 1 0.801
VRK2VRK2 0.811 -0.144 1 0.856
DMPK1DMPK1 0.811 0.353 -3 0.872
ACVR2BACVR2B 0.810 0.006 -2 0.843
PKCEPKCE 0.810 0.177 2 0.623
MAKMAK 0.810 0.279 -2 0.770
PAK5PAK5 0.809 0.132 -2 0.748
CDK19CDK19 0.809 -0.028 1 0.597
GRK2GRK2 0.809 -0.002 -2 0.742
P38AP38A 0.809 0.011 1 0.686
WNK4WNK4 0.809 0.038 -2 0.901
PKCIPKCI 0.809 0.105 2 0.643
JNK2JNK2 0.809 0.014 1 0.589
BRAFBRAF 0.808 0.024 -4 0.840
CRIKCRIK 0.807 0.358 -3 0.877
CHAK1CHAK1 0.807 -0.109 2 0.655
JNK3JNK3 0.807 -0.002 1 0.620
MLK4MLK4 0.807 -0.115 2 0.631
BMPR1ABMPR1A 0.807 0.048 1 0.769
GSK3AGSK3A 0.807 0.035 4 0.419
GSK3BGSK3B 0.806 0.005 4 0.414
MST3MST3 0.806 0.010 2 0.725
MEKK1MEKK1 0.806 -0.074 1 0.821
CDK18CDK18 0.806 -0.002 1 0.568
PAK4PAK4 0.806 0.123 -2 0.756
CDK1CDK1 0.805 -0.011 1 0.599
P38BP38B 0.805 0.016 1 0.614
MEK5MEK5 0.805 -0.106 2 0.725
CDK13CDK13 0.805 -0.044 1 0.611
TAO3TAO3 0.805 0.018 1 0.804
CDK5CDK5 0.805 -0.020 1 0.656
PKG1PKG1 0.805 0.256 -2 0.676
MEKK3MEKK3 0.804 -0.088 1 0.824
CDK14CDK14 0.804 0.045 1 0.620
PLK4PLK4 0.804 -0.072 2 0.524
CDK10CDK10 0.804 0.069 1 0.605
CK2A2CK2A2 0.803 0.095 1 0.720
CDK9CDK9 0.803 -0.029 1 0.620
TLK1TLK1 0.803 -0.034 -2 0.860
MOKMOK 0.803 0.264 1 0.716
GAKGAK 0.803 0.107 1 0.850
ROCK1ROCK1 0.803 0.300 -3 0.880
CDK2CDK2 0.803 -0.026 1 0.686
CK1ECK1E 0.803 -0.026 -3 0.524
NEK5NEK5 0.802 -0.084 1 0.840
PDK1PDK1 0.802 0.130 1 0.810
ERK2ERK2 0.802 -0.027 1 0.640
CDK12CDK12 0.802 -0.023 1 0.586
HRIHRI 0.801 -0.134 -2 0.904
IRAK4IRAK4 0.801 -0.058 1 0.799
GCKGCK 0.801 0.080 1 0.842
MEKK2MEKK2 0.801 -0.077 2 0.708
CDK17CDK17 0.801 -0.013 1 0.517
ERK1ERK1 0.800 -0.017 1 0.604
PRP4PRP4 0.800 -0.019 -3 0.687
ZAKZAK 0.800 -0.119 1 0.790
PERKPERK 0.800 -0.138 -2 0.886
P38GP38G 0.800 -0.008 1 0.512
CK1A2CK1A2 0.799 -0.001 -3 0.487
CK1G1CK1G1 0.798 -0.035 -3 0.532
PINK1PINK1 0.798 -0.138 1 0.803
CK1DCK1D 0.797 -0.011 -3 0.476
HPK1HPK1 0.797 0.076 1 0.829
GRK3GRK3 0.796 -0.011 -2 0.687
PLK2PLK2 0.796 0.000 -3 0.692
MPSK1MPSK1 0.796 0.006 1 0.791
TAO2TAO2 0.795 -0.034 2 0.746
IRAK1IRAK1 0.795 -0.108 -1 0.774
NEK8NEK8 0.795 -0.062 2 0.709
NEK11NEK11 0.795 -0.105 1 0.819
MST2MST2 0.795 -0.033 1 0.838
CDK3CDK3 0.794 0.001 1 0.535
LKB1LKB1 0.794 -0.040 -3 0.737
CAMKK2CAMKK2 0.793 -0.059 -2 0.844
CK2A1CK2A1 0.793 0.069 1 0.702
LOKLOK 0.791 0.022 -2 0.874
PBKPBK 0.791 0.091 1 0.792
MINKMINK 0.791 -0.016 1 0.828
TAK1TAK1 0.791 0.021 1 0.830
CAMKK1CAMKK1 0.790 -0.135 -2 0.837
KHS1KHS1 0.790 0.061 1 0.819
LRRK2LRRK2 0.790 -0.009 2 0.737
TNIKTNIK 0.789 -0.008 3 0.800
NEK4NEK4 0.789 -0.083 1 0.815
KHS2KHS2 0.789 0.069 1 0.831
CDK16CDK16 0.789 -0.011 1 0.530
HGKHGK 0.789 -0.036 3 0.793
SLKSLK 0.788 -0.003 -2 0.818
MST1MST1 0.788 -0.029 1 0.823
P38DP38D 0.788 -0.013 1 0.526
MEKK6MEKK6 0.787 -0.054 1 0.807
TTBK1TTBK1 0.787 -0.154 2 0.520
MAP3K15MAP3K15 0.786 -0.062 1 0.774
ERK7ERK7 0.786 -0.026 2 0.475
NEK1NEK1 0.786 -0.062 1 0.811
VRK1VRK1 0.784 -0.082 2 0.728
JNK1JNK1 0.783 -0.023 1 0.572
RIPK2RIPK2 0.783 -0.110 1 0.759
CDK4CDK4 0.782 -0.007 1 0.570
EEF2KEEF2K 0.781 -0.104 3 0.762
BUB1BUB1 0.780 0.046 -5 0.789
YSK1YSK1 0.780 -0.057 2 0.704
STK33STK33 0.779 -0.113 2 0.516
MEK2MEK2 0.779 -0.143 2 0.713
CDK6CDK6 0.778 -0.038 1 0.596
PDHK3_TYRPDHK3_TYR 0.774 0.163 4 0.750
TTKTTK 0.774 -0.016 -2 0.868
NEK3NEK3 0.773 -0.109 1 0.774
BIKEBIKE 0.773 0.065 1 0.744
YANK3YANK3 0.772 -0.029 2 0.329
HASPINHASPIN 0.771 0.020 -1 0.721
PDHK4_TYRPDHK4_TYR 0.769 0.115 2 0.806
MAP2K4_TYRMAP2K4_TYR 0.768 0.076 -1 0.893
OSR1OSR1 0.768 -0.095 2 0.698
MAP2K6_TYRMAP2K6_TYR 0.767 0.063 -1 0.889
TAO1TAO1 0.767 -0.044 1 0.745
MYO3BMYO3B 0.766 -0.062 2 0.712
MAP2K7_TYRMAP2K7_TYR 0.765 0.026 2 0.772
TESK1_TYRTESK1_TYR 0.765 0.010 3 0.847
MYO3AMYO3A 0.763 -0.070 1 0.806
ASK1ASK1 0.763 -0.085 1 0.755
BMPR2_TYRBMPR2_TYR 0.763 0.018 -1 0.869
PKMYT1_TYRPKMYT1_TYR 0.763 -0.027 3 0.823
CK1ACK1A 0.761 -0.037 -3 0.401
ALPHAK3ALPHAK3 0.761 -0.066 -1 0.778
PDHK1_TYRPDHK1_TYR 0.761 0.014 -1 0.885
PINK1_TYRPINK1_TYR 0.760 -0.021 1 0.821
LIMK2_TYRLIMK2_TYR 0.760 0.018 -3 0.798
AAK1AAK1 0.758 0.092 1 0.646
DDR1DDR1 0.755 -0.016 4 0.698
LIMK1_TYRLIMK1_TYR 0.754 -0.067 2 0.752
STLK3STLK3 0.754 -0.114 1 0.759
RETRET 0.754 -0.069 1 0.798
EPHB4EPHB4 0.752 -0.043 -1 0.858
EPHA6EPHA6 0.752 -0.021 -1 0.854
TXKTXK 0.749 0.024 1 0.841
MST1RMST1R 0.748 -0.113 3 0.764
TYRO3TYRO3 0.748 -0.112 3 0.752
YES1YES1 0.748 -0.049 -1 0.850
ROS1ROS1 0.747 -0.107 3 0.730
FGRFGR 0.747 -0.065 1 0.865
TYK2TYK2 0.747 -0.163 1 0.799
INSRRINSRR 0.747 -0.051 3 0.713
TNK2TNK2 0.746 -0.050 3 0.719
ABL2ABL2 0.746 -0.058 -1 0.816
DDR2DDR2 0.745 0.064 3 0.703
JAK3JAK3 0.744 -0.090 1 0.777
EPHA4EPHA4 0.744 -0.051 2 0.700
CSF1RCSF1R 0.744 -0.129 3 0.748
JAK2JAK2 0.743 -0.171 1 0.792
FERFER 0.743 -0.114 1 0.851
CK1G3CK1G3 0.743 -0.034 -3 0.362
ABL1ABL1 0.742 -0.069 -1 0.807
EPHB1EPHB1 0.742 -0.084 1 0.843
SRMSSRMS 0.742 -0.084 1 0.841
NEK10_TYRNEK10_TYR 0.742 -0.043 1 0.672
TNK1TNK1 0.741 -0.047 3 0.740
EPHB3EPHB3 0.741 -0.075 -1 0.844
EPHB2EPHB2 0.740 -0.061 -1 0.830
TNNI3K_TYRTNNI3K_TYR 0.740 -0.035 1 0.821
ITKITK 0.739 -0.083 -1 0.807
PDGFRBPDGFRB 0.739 -0.124 3 0.756
FGFR2FGFR2 0.739 -0.112 3 0.762
YANK2YANK2 0.738 -0.068 2 0.352
LCKLCK 0.737 -0.066 -1 0.814
KDRKDR 0.737 -0.098 3 0.714
BLKBLK 0.736 -0.032 -1 0.815
HCKHCK 0.736 -0.132 -1 0.819
JAK1JAK1 0.736 -0.103 1 0.761
AXLAXL 0.736 -0.112 3 0.737
KITKIT 0.735 -0.145 3 0.749
BMXBMX 0.734 -0.060 -1 0.738
MERTKMERTK 0.734 -0.107 3 0.737
NTRK1NTRK1 0.734 -0.139 -1 0.845
FGFR1FGFR1 0.734 -0.122 3 0.727
TECTEC 0.734 -0.078 -1 0.755
TEKTEK 0.733 -0.138 3 0.697
FLT3FLT3 0.733 -0.146 3 0.741
EPHA3EPHA3 0.733 -0.089 2 0.671
EPHA7EPHA7 0.733 -0.080 2 0.688
LTKLTK 0.733 -0.091 3 0.707
BTKBTK 0.732 -0.158 -1 0.786
FLT1FLT1 0.732 -0.089 -1 0.823
METMET 0.732 -0.119 3 0.740
FYNFYN 0.731 -0.045 -1 0.788
ALKALK 0.730 -0.133 3 0.682
NTRK2NTRK2 0.730 -0.139 3 0.719
EPHA5EPHA5 0.729 -0.059 2 0.686
EPHA1EPHA1 0.729 -0.095 3 0.702
PDGFRAPDGFRA 0.729 -0.206 3 0.753
FGFR3FGFR3 0.728 -0.116 3 0.733
INSRINSR 0.728 -0.128 3 0.689
PTK2BPTK2B 0.728 -0.064 -1 0.782
WEE1_TYRWEE1_TYR 0.727 -0.130 -1 0.785
PTK6PTK6 0.727 -0.185 -1 0.756
ERBB2ERBB2 0.726 -0.154 1 0.758
FLT4FLT4 0.725 -0.154 3 0.716
NTRK3NTRK3 0.725 -0.126 -1 0.803
PTK2PTK2 0.724 -0.020 -1 0.764
LYNLYN 0.722 -0.131 3 0.679
EPHA8EPHA8 0.721 -0.100 -1 0.809
SRCSRC 0.721 -0.100 -1 0.792
FRKFRK 0.719 -0.158 -1 0.822
EGFREGFR 0.718 -0.099 1 0.663
FGFR4FGFR4 0.717 -0.102 -1 0.777
MATKMATK 0.717 -0.136 -1 0.744
CK1G2CK1G2 0.716 -0.070 -3 0.450
CSKCSK 0.716 -0.144 2 0.690
IGF1RIGF1R 0.714 -0.127 3 0.641
EPHA2EPHA2 0.712 -0.100 -1 0.778
SYKSYK 0.712 -0.073 -1 0.752
ERBB4ERBB4 0.706 -0.094 1 0.689
MUSKMUSK 0.703 -0.171 1 0.664
FESFES 0.697 -0.145 -1 0.716
ZAP70ZAP70 0.687 -0.091 -1 0.691