Motif 1219 (n=196)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYG9 | ARPC4-TTLL3 | T4 | ochoa | Protein ARPC4-TTLL3 | None |
| A6NMY6 | ANXA2P2 | T3 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| C9JAW5 | None | T3 | ochoa | HIG1 domain-containing protein | None |
| M0R2N4 | None | Y4 | ochoa | C3H1-type domain-containing protein | None |
| O00560 | SDCBP | Y4 | ochoa|psp | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O14613 | CDC42EP2 | T3 | ochoa | Cdc42 effector protein 2 (Binder of Rho GTPases 1) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| O14907 | TAX1BP3 | Y3 | ochoa | Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) | May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}. |
| O15020 | SPTBN2 | T4 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15037 | KHNYN | T3 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15400 | STX7 | Y3 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15400 | STX7 | T4 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43167 | ZBTB24 | T4 | ochoa | Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) | May be involved in BMP2-induced transcription. {ECO:0000250}. |
| O43491 | EPB41L2 | T3 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43707 | ACTN4 | Y4 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43719 | HTATSF1 | T4 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60684 | KPNA6 | T3 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O60739 | EIF1B | T3 | ochoa | Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20) | Probably involved in translation. |
| O75340 | PDCD6 | Y4 | ochoa | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250|UniProtKB:P12815, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25667979, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779, ECO:0000269|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250|UniProtKB:P12815}. |
| O75531 | BANF1 | T3 | ochoa|psp | Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] | Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32792394). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (PubMed:32792394). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (PubMed:31796734). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (PubMed:25991860). In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication (PubMed:18005698). {ECO:0000269|PubMed:10908652, ECO:0000269|PubMed:11792822, ECO:0000269|PubMed:12163470, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:25991860, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:9465049}.; FUNCTION: (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome (PubMed:11005805, PubMed:16680152, PubMed:9465049). EMD and BAF are cooperative cofactors of HIV-1 infection (PubMed:16680152). Association of EMD with the viral DNA requires the presence of BAF and viral integrase (PubMed:16680152). The association of viral DNA with chromatin requires the presence of BAF and EMD (PubMed:16680152). {ECO:0000269|PubMed:11005805, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:9465049}. |
| O75821 | EIF3G | T3 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O95070 | YIF1A | Y3 | ochoa | Protein YIF1A (54TMp) (YIP1-interacting factor homolog A) | Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000269|PubMed:15990086}. |
| O95456 | PSMG1 | T4 | ochoa | Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| P00338 | LDHA | T3 | psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00492 | HPRT1 | T3 | ochoa | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| P04075 | ALDOA | Y3 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05387 | RPLP2 | Y3 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P05783 | KRT18 | T4 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06493 | CDK1 | Y4 | psp | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P06730 | EIF4E | T3 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07355 | ANXA2 | T3 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08670 | VIM | T3 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09211 | GSTP1 | Y4 | psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P09914 | IFIT1 | T3 | ochoa | Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1) | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486). {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:28251928, ECO:0000269|PubMed:36285486, ECO:0000269|PubMed:39009378}. |
| P10412 | H1-4 | T4 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P11836 | MS4A1 | T3 | ochoa | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
| P12814 | ACTN1 | Y4 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P14621 | ACYP2 | T3 | ochoa | Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2) | Its physiological role is not yet clear. |
| P16401 | H1-5 | T4 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | T4 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | T4 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16885 | PLCG2 | T3 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P20338 | RAB4A | T4 | ochoa | Ras-related protein Rab-4A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}. |
| P20340 | RAB6A | T3 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P20472 | PVALB | T4 | ochoa | Parvalbumin alpha (Alpha-parvalbumin) (Alpha-PV) | In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (PubMed:15122922, PubMed:39584689). {ECO:0000250|UniProtKB:P02624, ECO:0000269|PubMed:15122922, ECO:0000269|PubMed:39584689}. |
| P22234 | PAICS | T3 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P22626 | HNRNPA2B1 | T4 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P25205 | MCM3 | T4 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P27707 | DCK | T3 | ochoa|psp | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P35222 | CTNNB1 | T3 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35998 | PSMC2 | Y4 | ochoa | 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}. |
| P40121 | CAPG | T3 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P41212 | ETV6 | T4 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41743 | PRKCI | T3 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P42025 | ACTR1B | Y4 | ochoa | Beta-centractin (Actin-related protein 1B) (ARP1B) | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| P42858 | HTT | T3 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46821 | MAP1B | T3 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47974 | ZFP36L2 | T3 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P47974 | ZFP36L2 | T4 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48426 | PIP4K2A | T3 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}. |
| P49189 | ALDH9A1 | T3 | ochoa | 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] | Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}. |
| P49721 | PSMB2 | Y3 | ochoa | Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P49902 | NT5C2 | T3 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P49959 | MRE11 | T3 | ochoa | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50402 | EMD | Y4 | psp | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50548 | ERF | T3 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P51532 | SMARCA4 | T3 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52292 | KPNA2 | T3 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P52294 | KPNA1 | T3 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P53611 | RABGGTB | T3 | ochoa | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}. |
| P54578 | USP14 | Y4 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55160 | NCKAP1L | T4 | ochoa | Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) | Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000269|PubMed:32647003, ECO:0000303|PubMed:20969869}. |
| P57088 | TMEM33 | T4 | ochoa | Transmembrane protein 33 (Protein DB83) (SHINC-3) | Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377). {ECO:0000250|UniProtKB:Q9CR67, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696, ECO:0000269|PubMed:30760708, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34487377}. |
| P59998 | ARPC4 | T4 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| P61019 | RAB2A | Y3 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P61163 | ACTR1A | Y4 | ochoa | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| P61978 | HNRNPK | T3 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P63172 | DYNLT1 | Y4 | ochoa | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274). {ECO:0000250, ECO:0000269|PubMed:27502274}.; FUNCTION: (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}. |
| Q01081 | U2AF1 | Y4 | ochoa | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
| Q02539 | H1-1 | T4 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q02978 | SLC25A11 | T4 | ochoa | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) | Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). {ECO:0000250|UniProtKB:P22292, ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:21448454}. |
| Q06265 | EXOSC9 | T4 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q06330 | RBPJ | T4 | ochoa | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250|UniProtKB:P31266, ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}. |
| Q08945 | SSRP1 | T4 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q13148 | TARDBP | Y4 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13206 | DDX10 | T4 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13451 | FKBP5 | T3 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q13464 | ROCK1 | T3 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13573 | SNW1 | T4 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q14151 | SAFB2 | T4 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14676 | MDC1 | T4 | ochoa|psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15020 | SART3 | T3 | ochoa | Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}. |
| Q15637 | SF1 | T3 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q15836 | VAMP3 | T3 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q16186 | ADRM1 | T3 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q16543 | CDC37 | Y4 | ochoa|psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q5SSJ5 | HP1BP3 | T3 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T0W9 | FAM83B | T3 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T4S7 | UBR4 | T3 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5VV17 | OTUD1 | Y4 | ochoa | OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) | Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36445135}. |
| Q6NSJ2 | PHLDB3 | T3 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6PKG0 | LARP1 | T3 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6SZW1 | SARM1 | T4 | ochoa | NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439792, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). {ECO:0000250|UniProtKB:Q6PDS3, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:16964262, ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:25908823, ECO:0000269|PubMed:27671644, ECO:0000269|PubMed:28334607, ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:30333228, ECO:0000269|PubMed:31128467, ECO:0000269|PubMed:31439792, ECO:0000269|PubMed:31439793, ECO:0000269|PubMed:32049506, ECO:0000269|PubMed:32828421, ECO:0000269|PubMed:33053563}. |
| Q75N03 | CBLL1 | T4 | ochoa | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. |
| Q7Z3U7 | MON2 | T4 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q86TI2 | DPP9 | T3 | ochoa | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36112693, ECO:0000269|PubMed:36357533}. |
| Q86TI2 | DPP9 | T4 | ochoa | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36112693, ECO:0000269|PubMed:36357533}. |
| Q86Y82 | STX12 | Y3 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q8IWZ3 | ANKHD1 | T3 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N3J5 | PPM1K | T3 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8NEL9 | DDHD1 | Y3 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NI77 | KIF18A | T4 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TBE7 | SLC35G2 | T3 | ochoa | Solute carrier family 35 member G2 (Transmembrane protein 22) | None |
| Q8TF42 | UBASH3B | Y4 | ochoa | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}. |
| Q8WTW3 | COG1 | T3 | ochoa | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | Required for normal Golgi function. {ECO:0000250}. |
| Q8WU68 | U2AF1L4 | Y4 | ochoa | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Q8WUD1 | RAB2B | Y3 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q92599 | SEPTIN8 | T4 | ochoa | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92621 | NUP205 | T3 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q92945 | KHSRP | Y4 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96C00 | ZBTB9 | T3 | ochoa | Zinc finger and BTB domain-containing protein 9 | May be involved in transcriptional regulation. |
| Q96C19 | EFHD2 | T3 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96C55 | ZNF524 | T3 | ochoa | Zinc finger protein 524 | May be involved in transcriptional regulation. |
| Q96DF8 | ESS2 | T3 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96FV9 | THOC1 | T4 | ochoa | THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96HR3 | MED30 | T3 | ochoa | Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}. |
| Q96LT7 | C9orf72 | T3 | ochoa | Guanine nucleotide exchange factor C9orf72 | Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531, PubMed:37821429). Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy (PubMed:37821429). Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Promotes initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to CFL1/cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q6DFW0, ECO:0000269|PubMed:24549040, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27334615, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:27723745, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654, ECO:0000269|PubMed:37821429}.; FUNCTION: [Isoform 1]: Regulates stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}.; FUNCTION: [Isoform 2]: Does not play a role in regulation of stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}. |
| Q96MH2 | HEXIM2 | T4 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96QK1 | VPS35 | T4 | ochoa | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. |
| Q99439 | CNN2 | T4 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99848 | EBNA1BP2 | T3 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q99865 | SPIN2A | T3 | ochoa | Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A) | May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000250|UniProtKB:Q9BPZ2, ECO:0000269|PubMed:29061846}. |
| Q9BPY3 | FAM118B | T4 | ochoa | Protein FAM118B | May play a role in Cajal bodies formation. {ECO:0000269|PubMed:24569877}. |
| Q9BPZ2 | SPIN2B | T3 | ochoa | Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) | Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000269|PubMed:12145692, ECO:0000269|PubMed:29061846}. |
| Q9BR77 | CCDC77 | T4 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BTU6 | PI4K2A | T4 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BVC4 | MLST8 | T3 | ochoa | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) | Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}. |
| Q9C0B1 | FTO | T4 | ochoa|psp | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9H2U1 | DHX36 | Y3 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H840 | GEMIN7 | T3 | ochoa | Gem-associated protein 7 (Gemin-7) (SIP3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}. |
| Q9HCD5 | NCOA5 | T3 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NUP7 | TRMT13 | T3 | ochoa | tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) | tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}. |
| Q9NVD7 | PARVA | T3 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NVH1 | DNAJC11 | T3 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NW15 | ANO10 | T4 | ochoa | Anoctamin-10 (Transmembrane protein 16K) | Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}. |
| Q9NYJ1 | COA4 | T3 | ochoa | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein) | Putative COX assembly factor. {ECO:0000250}. |
| Q9NZ32 | ACTR10 | Y4 | ochoa | Actin-related protein 10 (Actin-related protein 11) (hARP11) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:I3LHK5}. |
| Q9UGP4 | LIMD1 | Y4 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHD2 | TBK1 | T4 | ochoa | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UIM3 | FKBPL | T3 | ochoa | FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39) (WISp39) | May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. {ECO:0000269|PubMed:15664193}. |
| Q9UK76 | JPT1 | T3 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKY7 | CDV3 | T4 | ochoa | Protein CDV3 homolog | None |
| Q9UM13 | ANAPC10 | T3 | ochoa | Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UNF1 | MAGED2 | T4 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9Y241 | HIGD1A | T3 | ochoa | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9Y277 | VDAC3 | T4 | ochoa | Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). {ECO:0000250|UniProtKB:Q60931, ECO:0000269|PubMed:31935282}. |
| Q9Y284 | WDR83OS | T3 | ochoa | PAT complex subunit Asterix (Protein associated with the ER translocon of 10kDa) (PAT-10) (PAT10) (WD repeat domain 83 opposite strand) (WDR83 opposite strand) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:12475939, PubMed:32814900, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:32814900, PubMed:36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity). {ECO:0000250|UniProtKB:A0A8I3NQW8, ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:36261522}. |
| Q9Y2J2 | EPB41L3 | T3 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y421 | FAM32A | Y4 | ochoa | Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12) | Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. {ECO:0000269|PubMed:21339736}. |
| S4R3Y5 | MTRNR2L11 | T3 | ochoa | Humanin-like 11 (HN11) (MT-RNR2-like protein 11) | Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}. |
| Q7LDG7 | RASGRP2 | T4 | Sugiyama | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| P18621 | RPL17 | Y4 | Sugiyama | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O75190 | DNAJB6 | Y4 | Sugiyama | DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:28233300}.; FUNCTION: [Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation. {ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}. |
| P17029 | ZKSCAN1 | T3 | Sugiyama | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P68431 | H3C1 | T4 | GPS6|SIGNOR|EPSD | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P84243 | H3-3A | T4 | GPS6|EPSD | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q16695 | H3-4 | T4 | GPS6 | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q71DI3 | H3C15 | T4 | GPS6|EPSD | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| C9JLW8 | MCRIP1 | S3 | ochoa | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}. |
| H3BQ06 | None | S3 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. {ECO:0000256|ARBA:ARBA00046245}. |
| O15156 | ZBTB7B | S3 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O60678 | PRMT3 | S3 | ochoa | Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) | Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566, PubMed:39513743). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:22795084). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (PubMed:25728001, PubMed:31378783, PubMed:39513743). Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783). {ECO:0000250|UniProtKB:Q922H1, ECO:0000269|PubMed:22795084, ECO:0000269|PubMed:23445220, ECO:0000269|PubMed:25728001, ECO:0000269|PubMed:31378783, ECO:0000269|PubMed:33495566, ECO:0000269|PubMed:39513743}. |
| O75694 | NUP155 | S3 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| P35520 | CBS | S3 | ochoa | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P46734 | MAP2K3 | S3 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P55055 | NR1H2 | S3 | ochoa | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}. |
| Q07065 | CKAP4 | S3 | psp | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| Q13671 | RIN1 | S3 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14004 | CDK13 | S3 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14938 | NFIX | S3 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q17RC7 | EXOC3L4 | S3 | ochoa | Exocyst complex component 3-like protein 4 | None |
| Q32MZ4 | LRRFIP1 | S3 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q53T59 | HS1BP3 | S3 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5BKX5 | ACTMAP | S3 | ochoa | Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) | Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}. |
| Q6DD88 | ATL3 | S3 | ochoa | Atlastin-3 (AT3) (ATL-3) (EC 3.6.5.-) | Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:24459106, PubMed:27619977, PubMed:37102997). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:37102997}. |
| Q8N302 | AGGF1 | S3 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N461 | FBXL16 | S3 | ochoa | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q8TEU7 | RAPGEF6 | S3 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WUX9 | CHMP7 | S3 | psp | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Q9BQG0 | MYBBP1A | S3 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9H875 | PRKRIP1 | S3 | ochoa | PRKR-interacting protein 1 | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| Q9H9Z2 | LIN28A | S3 | ochoa | Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1) | RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:22118463, ECO:0000269|PubMed:22898984, ECO:0000305}. |
| Q9NWS9 | ZNF446 | S3 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NXH3 | PPP1R14D | S3 | ochoa | Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) | Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}. |
| Q9UEY8 | ADD3 | S3 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9ULP9 | TBC1D24 | S3 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| P53778 | MAPK12 | S3 | ELM|iPTMNet|EPSD|PSP | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.980084e-08 | 7.526 |
| R-HSA-75153 | Apoptotic execution phase | 6.324968e-08 | 7.199 |
| R-HSA-2262752 | Cellular responses to stress | 4.450882e-08 | 7.352 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.352739e-08 | 7.029 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.857735e-07 | 6.731 |
| R-HSA-5357801 | Programmed Cell Death | 4.652520e-07 | 6.332 |
| R-HSA-2559583 | Cellular Senescence | 6.053661e-07 | 6.218 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.879781e-07 | 6.052 |
| R-HSA-68875 | Mitotic Prophase | 2.349368e-06 | 5.629 |
| R-HSA-68886 | M Phase | 2.405394e-06 | 5.619 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 3.894788e-06 | 5.410 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.511347e-06 | 5.259 |
| R-HSA-109581 | Apoptosis | 6.682635e-06 | 5.175 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.430840e-05 | 4.844 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.631314e-05 | 4.787 |
| R-HSA-69306 | DNA Replication | 2.244259e-05 | 4.649 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.426683e-05 | 4.465 |
| R-HSA-1640170 | Cell Cycle | 4.581415e-05 | 4.339 |
| R-HSA-446728 | Cell junction organization | 5.486721e-05 | 4.261 |
| R-HSA-1500931 | Cell-Cell communication | 5.262650e-05 | 4.279 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.306186e-05 | 4.200 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.306186e-05 | 4.200 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 9.750400e-05 | 4.011 |
| R-HSA-69481 | G2/M Checkpoints | 1.397410e-04 | 3.855 |
| R-HSA-912446 | Meiotic recombination | 1.570331e-04 | 3.804 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.681864e-04 | 3.774 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.144102e-04 | 3.669 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.624084e-04 | 3.581 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.067920e-04 | 3.513 |
| R-HSA-421270 | Cell-cell junction organization | 3.180011e-04 | 3.498 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.335732e-04 | 3.477 |
| R-HSA-68882 | Mitotic Anaphase | 3.686489e-04 | 3.433 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.601540e-04 | 3.444 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.818084e-04 | 3.418 |
| R-HSA-418990 | Adherens junctions interactions | 3.953605e-04 | 3.403 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.276860e-04 | 3.369 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.304497e-04 | 3.366 |
| R-HSA-168256 | Immune System | 4.473833e-04 | 3.349 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.834657e-04 | 3.316 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.834657e-04 | 3.316 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.812605e-04 | 3.167 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.076147e-04 | 3.150 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.759251e-04 | 3.110 |
| R-HSA-9824272 | Somitogenesis | 7.800434e-04 | 3.108 |
| R-HSA-157118 | Signaling by NOTCH | 8.131481e-04 | 3.090 |
| R-HSA-1266695 | Interleukin-7 signaling | 8.460963e-04 | 3.073 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 9.366082e-04 | 3.028 |
| R-HSA-9020591 | Interleukin-12 signaling | 9.954905e-04 | 3.002 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.064347e-03 | 2.973 |
| R-HSA-9766229 | Degradation of CDH1 | 1.075502e-03 | 2.968 |
| R-HSA-8953854 | Metabolism of RNA | 1.142776e-03 | 2.942 |
| R-HSA-5334118 | DNA methylation | 1.319354e-03 | 2.880 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.346267e-03 | 2.871 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.410819e-03 | 2.851 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.259959e-03 | 2.900 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.382781e-03 | 2.859 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.446792e-03 | 2.840 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.446792e-03 | 2.840 |
| R-HSA-1500620 | Meiosis | 1.662479e-03 | 2.779 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.664288e-03 | 2.779 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.781608e-03 | 2.749 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.904877e-03 | 2.720 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.904877e-03 | 2.720 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.946875e-03 | 2.711 |
| R-HSA-6798695 | Neutrophil degranulation | 2.015146e-03 | 2.696 |
| R-HSA-8873719 | RAB geranylgeranylation | 2.312156e-03 | 2.636 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.312156e-03 | 2.636 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.335912e-03 | 2.632 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.410120e-03 | 2.618 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.616686e-03 | 2.582 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.590693e-03 | 2.587 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.616686e-03 | 2.582 |
| R-HSA-449147 | Signaling by Interleukins | 2.691850e-03 | 2.570 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.696147e-03 | 2.569 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.768775e-03 | 2.558 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.004511e-03 | 2.522 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.004511e-03 | 2.522 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.311429e-03 | 2.480 |
| R-HSA-72172 | mRNA Splicing | 3.351027e-03 | 2.475 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.465486e-03 | 2.460 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.504013e-03 | 2.455 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.793274e-03 | 2.421 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.793274e-03 | 2.421 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.516405e-03 | 2.454 |
| R-HSA-195721 | Signaling by WNT | 3.847609e-03 | 2.415 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.051001e-03 | 2.392 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.084556e-03 | 2.389 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.355318e-03 | 2.361 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.355318e-03 | 2.361 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.084556e-03 | 2.389 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.355318e-03 | 2.361 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.129989e-03 | 2.384 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.362261e-03 | 2.360 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.964713e-03 | 2.402 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.589278e-03 | 2.338 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.707728e-03 | 2.327 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.832046e-03 | 2.316 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.245233e-03 | 2.280 |
| R-HSA-9907900 | Proteasome assembly | 5.400597e-03 | 2.268 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.400597e-03 | 2.268 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.832046e-03 | 2.316 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.083798e-03 | 2.294 |
| R-HSA-9710421 | Defective pyroptosis | 5.048287e-03 | 2.297 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.083798e-03 | 2.294 |
| R-HSA-74160 | Gene expression (Transcription) | 4.990141e-03 | 2.302 |
| R-HSA-211000 | Gene Silencing by RNA | 5.506407e-03 | 2.259 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.835499e-03 | 2.234 |
| R-HSA-212436 | Generic Transcription Pathway | 5.891476e-03 | 2.230 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.153748e-03 | 2.211 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.184130e-03 | 2.209 |
| R-HSA-162906 | HIV Infection | 6.240673e-03 | 2.205 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.555209e-03 | 2.183 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.973664e-03 | 2.157 |
| R-HSA-168249 | Innate Immune System | 7.181539e-03 | 2.144 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.442018e-03 | 2.128 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 8.333906e-03 | 2.079 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 8.495286e-03 | 2.071 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.674844e-03 | 2.062 |
| R-HSA-68949 | Orc1 removal from chromatin | 8.823214e-03 | 2.054 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 8.823214e-03 | 2.054 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 9.330920e-03 | 2.030 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.553663e-03 | 2.020 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 9.857283e-03 | 2.006 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.134532e-02 | 1.945 |
| R-HSA-69206 | G1/S Transition | 1.164620e-02 | 1.934 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.225867e-02 | 1.912 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.425690e-02 | 1.846 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.277754e-02 | 1.894 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.363874e-02 | 1.865 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.463368e-02 | 1.835 |
| R-HSA-1474165 | Reproduction | 1.404706e-02 | 1.852 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.463368e-02 | 1.835 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.476862e-02 | 1.831 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.524888e-02 | 1.817 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.566871e-02 | 1.805 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.674398e-02 | 1.776 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.674398e-02 | 1.776 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.735447e-02 | 1.761 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.901578e-02 | 1.721 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.735447e-02 | 1.761 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.824262e-02 | 1.739 |
| R-HSA-162592 | Integration of provirus | 1.735447e-02 | 1.761 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.957583e-02 | 1.708 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.931336e-02 | 1.714 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.901578e-02 | 1.721 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.901578e-02 | 1.721 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.021248e-02 | 1.694 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.021248e-02 | 1.694 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.824262e-02 | 1.739 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.785964e-02 | 1.748 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.785964e-02 | 1.748 |
| R-HSA-169911 | Regulation of Apoptosis | 1.901578e-02 | 1.721 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.797650e-02 | 1.745 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.735447e-02 | 1.761 |
| R-HSA-9824446 | Viral Infection Pathways | 1.897649e-02 | 1.722 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.099992e-02 | 1.678 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.099992e-02 | 1.678 |
| R-HSA-4641258 | Degradation of DVL | 2.144980e-02 | 1.669 |
| R-HSA-4641257 | Degradation of AXIN | 2.144980e-02 | 1.669 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.144980e-02 | 1.669 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.187603e-02 | 1.660 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.190955e-02 | 1.659 |
| R-HSA-69239 | Synthesis of DNA | 2.219402e-02 | 1.654 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.404635e-02 | 1.619 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.540556e-02 | 1.595 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.680534e-02 | 1.572 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.277421e-02 | 1.643 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.540556e-02 | 1.595 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.690086e-02 | 1.570 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.680534e-02 | 1.572 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.690086e-02 | 1.570 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.824563e-02 | 1.549 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.824563e-02 | 1.549 |
| R-HSA-9758941 | Gastrulation | 2.513741e-02 | 1.600 |
| R-HSA-8939211 | ESR-mediated signaling | 2.260264e-02 | 1.646 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.824563e-02 | 1.549 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.824563e-02 | 1.549 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.658977e-02 | 1.575 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.540556e-02 | 1.595 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.680534e-02 | 1.572 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.680534e-02 | 1.572 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.404635e-02 | 1.619 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.404635e-02 | 1.619 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.327929e-02 | 1.633 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.540556e-02 | 1.595 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.680534e-02 | 1.572 |
| R-HSA-69541 | Stabilization of p53 | 2.404635e-02 | 1.619 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.863264e-02 | 1.543 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.955200e-02 | 1.529 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.955200e-02 | 1.529 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.955200e-02 | 1.529 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.955200e-02 | 1.529 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.994063e-02 | 1.524 |
| R-HSA-9610379 | HCMV Late Events | 3.056915e-02 | 1.515 |
| R-HSA-162587 | HIV Life Cycle | 3.056915e-02 | 1.515 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.076642e-02 | 1.512 |
| R-HSA-8854214 | TBC/RABGAPs | 3.124735e-02 | 1.505 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.124735e-02 | 1.505 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.186758e-02 | 1.497 |
| R-HSA-977225 | Amyloid fiber formation | 3.186758e-02 | 1.497 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.230261e-02 | 1.491 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.280853e-02 | 1.484 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.440975e-02 | 1.463 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.440975e-02 | 1.463 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.440975e-02 | 1.463 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.440975e-02 | 1.463 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.440975e-02 | 1.463 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 4.112091e-02 | 1.386 |
| R-HSA-72187 | mRNA 3'-end processing | 4.672295e-02 | 1.330 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.022010e-02 | 1.396 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.022010e-02 | 1.396 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.022010e-02 | 1.396 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.809003e-02 | 1.419 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.773158e-02 | 1.423 |
| R-HSA-3371556 | Cellular response to heat stress | 3.531425e-02 | 1.452 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 4.112091e-02 | 1.386 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.300983e-02 | 1.366 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.672295e-02 | 1.330 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.281316e-02 | 1.368 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.484713e-02 | 1.348 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.452520e-02 | 1.351 |
| R-HSA-194138 | Signaling by VEGF | 4.022010e-02 | 1.396 |
| R-HSA-373753 | Nephrin family interactions | 4.423938e-02 | 1.354 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.484713e-02 | 1.348 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.121131e-02 | 1.385 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.121131e-02 | 1.385 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.722952e-02 | 1.429 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.150469e-02 | 1.382 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 4.744263e-02 | 1.324 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 4.744263e-02 | 1.324 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 4.744263e-02 | 1.324 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.863701e-02 | 1.313 |
| R-HSA-168255 | Influenza Infection | 5.026536e-02 | 1.299 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 5.072789e-02 | 1.295 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.177589e-02 | 1.286 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.177589e-02 | 1.286 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.177589e-02 | 1.286 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.177589e-02 | 1.286 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.177589e-02 | 1.286 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.177589e-02 | 1.286 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.177589e-02 | 1.286 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.177589e-02 | 1.286 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.177589e-02 | 1.286 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.177589e-02 | 1.286 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.177589e-02 | 1.286 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 5.177589e-02 | 1.286 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.257869e-02 | 1.279 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.257869e-02 | 1.279 |
| R-HSA-350054 | Notch-HLH transcription pathway | 5.409246e-02 | 1.267 |
| R-HSA-166208 | mTORC1-mediated signalling | 5.409246e-02 | 1.267 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.562553e-02 | 1.255 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.562553e-02 | 1.255 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.731834e-02 | 1.242 |
| R-HSA-69275 | G2/M Transition | 5.751224e-02 | 1.240 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 6.429738e-02 | 1.192 |
| R-HSA-171306 | Packaging Of Telomere Ends | 7.201438e-02 | 1.143 |
| R-HSA-9615710 | Late endosomal microautophagy | 7.964995e-02 | 1.099 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 7.964995e-02 | 1.099 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 8.355835e-02 | 1.078 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 8.752417e-02 | 1.058 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 8.752417e-02 | 1.058 |
| R-HSA-191859 | snRNP Assembly | 6.090742e-02 | 1.215 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.090742e-02 | 1.215 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.736704e-02 | 1.111 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 8.355835e-02 | 1.078 |
| R-HSA-3214842 | HDMs demethylate histones | 6.463589e-02 | 1.190 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.027864e-02 | 1.153 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.027864e-02 | 1.153 |
| R-HSA-525793 | Myogenesis | 6.829182e-02 | 1.166 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.951046e-02 | 1.100 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.736704e-02 | 1.111 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 6.429738e-02 | 1.192 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.736704e-02 | 1.111 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 7.580120e-02 | 1.120 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.969229e-02 | 1.224 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 6.429738e-02 | 1.192 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.103123e-02 | 1.091 |
| R-HSA-9609646 | HCMV Infection | 7.062694e-02 | 1.151 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.379764e-02 | 1.132 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.170975e-02 | 1.144 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.519287e-02 | 1.186 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 6.104902e-02 | 1.214 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.528902e-02 | 1.185 |
| R-HSA-9612973 | Autophagy | 8.411922e-02 | 1.075 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.381702e-02 | 1.195 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 6.829182e-02 | 1.166 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.104091e-02 | 1.091 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.104091e-02 | 1.091 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.171372e-02 | 1.088 |
| R-HSA-1632852 | Macroautophagy | 6.116964e-02 | 1.213 |
| R-HSA-69242 | S Phase | 7.214064e-02 | 1.142 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.201802e-02 | 1.143 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.800522e-02 | 1.108 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 7.580120e-02 | 1.120 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.214064e-02 | 1.142 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.753285e-02 | 1.170 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.736704e-02 | 1.111 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.528902e-02 | 1.185 |
| R-HSA-1280218 | Adaptive Immune System | 7.694977e-02 | 1.114 |
| R-HSA-5218859 | Regulated Necrosis | 8.171372e-02 | 1.088 |
| R-HSA-5688426 | Deubiquitination | 7.613516e-02 | 1.118 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 6.829182e-02 | 1.166 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 8.670427e-02 | 1.062 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.161101e-02 | 1.210 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.981154e-02 | 1.156 |
| R-HSA-351202 | Metabolism of polyamines | 6.308042e-02 | 1.200 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.354208e-02 | 1.197 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 8.670427e-02 | 1.062 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.800522e-02 | 1.108 |
| R-HSA-202403 | TCR signaling | 8.104091e-02 | 1.091 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.864288e-02 | 1.052 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 8.884875e-02 | 1.051 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 8.884875e-02 | 1.051 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.884875e-02 | 1.051 |
| R-HSA-5632684 | Hedgehog 'on' state | 8.924705e-02 | 1.049 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.047937e-02 | 1.043 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 9.154524e-02 | 1.038 |
| R-HSA-1538133 | G0 and Early G1 | 9.154524e-02 | 1.038 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 9.182091e-02 | 1.037 |
| R-HSA-913531 | Interferon Signaling | 9.218219e-02 | 1.035 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 9.561942e-02 | 1.019 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 9.561942e-02 | 1.019 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.657622e-02 | 1.015 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.657622e-02 | 1.015 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.708185e-02 | 1.013 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.861019e-02 | 1.006 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 9.974463e-02 | 1.001 |
| R-HSA-5693538 | Homology Directed Repair | 1.006641e-01 | 0.997 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.008829e-01 | 0.996 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.008829e-01 | 0.996 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.008829e-01 | 0.996 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.127589e-01 | 0.948 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.127589e-01 | 0.948 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.127589e-01 | 0.948 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 1.127589e-01 | 0.948 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.244787e-01 | 0.905 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.244787e-01 | 0.905 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 1.244787e-01 | 0.905 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 1.244787e-01 | 0.905 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.587216e-01 | 0.799 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.808062e-01 | 0.743 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.808062e-01 | 0.743 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.916312e-01 | 0.718 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.916312e-01 | 0.718 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.916312e-01 | 0.718 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.916312e-01 | 0.718 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.916312e-01 | 0.718 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.916312e-01 | 0.718 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.916312e-01 | 0.718 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.023138e-01 | 0.694 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.023138e-01 | 0.694 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.039188e-01 | 0.983 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.433753e-01 | 0.844 |
| R-HSA-72649 | Translation initiation complex formation | 1.997166e-01 | 0.700 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.681286e-01 | 0.774 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.587216e-01 | 0.799 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.343473e-01 | 0.872 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.247630e-01 | 0.904 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.360444e-01 | 0.866 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.808062e-01 | 0.743 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.758651e-01 | 0.755 |
| R-HSA-1221632 | Meiotic synapsis | 1.949133e-01 | 0.710 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.853536e-01 | 0.732 |
| R-HSA-4839726 | Chromatin organization | 1.507926e-01 | 0.822 |
| R-HSA-3214847 | HATs acetylate histones | 1.811779e-01 | 0.742 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.744480e-01 | 0.758 |
| R-HSA-9609690 | HCMV Early Events | 1.601139e-01 | 0.796 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 1.244787e-01 | 0.905 |
| R-HSA-8875656 | MET receptor recycling | 1.360444e-01 | 0.866 |
| R-HSA-176974 | Unwinding of DNA | 1.474580e-01 | 0.831 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.587216e-01 | 0.799 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.916312e-01 | 0.718 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.916312e-01 | 0.718 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.023138e-01 | 0.694 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.571450e-01 | 0.804 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.808062e-01 | 0.743 |
| R-HSA-5205647 | Mitophagy | 1.039188e-01 | 0.983 |
| R-HSA-165159 | MTOR signalling | 1.433753e-01 | 0.844 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.023138e-01 | 0.694 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.770939e-01 | 0.752 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.127589e-01 | 0.948 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 1.244787e-01 | 0.905 |
| R-HSA-9734207 | Nucleotide salvage defects | 1.360444e-01 | 0.866 |
| R-HSA-164843 | 2-LTR circle formation | 1.587216e-01 | 0.799 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.808062e-01 | 0.743 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.978561e-01 | 0.704 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.474580e-01 | 0.831 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.039188e-01 | 0.983 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.996910e-01 | 0.700 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.360935e-01 | 0.866 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.571450e-01 | 0.804 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.127589e-01 | 0.948 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.474580e-01 | 0.831 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.587216e-01 | 0.799 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.916312e-01 | 0.718 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 1.916312e-01 | 0.718 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.023138e-01 | 0.694 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.298837e-01 | 0.886 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.655206e-01 | 0.781 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.343473e-01 | 0.872 |
| R-HSA-199991 | Membrane Trafficking | 1.822348e-01 | 0.739 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.167155e-01 | 0.933 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.752387e-01 | 0.756 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.038453e-01 | 0.984 |
| R-HSA-73927 | Depurination | 1.210661e-01 | 0.917 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.360444e-01 | 0.866 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 2.023138e-01 | 0.694 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.023138e-01 | 0.694 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.210661e-01 | 0.917 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.617893e-01 | 0.791 |
| R-HSA-9663891 | Selective autophagy | 1.398861e-01 | 0.854 |
| R-HSA-5689603 | UCH proteinases | 1.024182e-01 | 0.990 |
| R-HSA-74217 | Purine salvage | 1.210661e-01 | 0.917 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.150238e-01 | 0.939 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.587216e-01 | 0.799 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.784062e-01 | 0.749 |
| R-HSA-157579 | Telomere Maintenance | 1.746185e-01 | 0.758 |
| R-HSA-447043 | Neurofascin interactions | 1.127589e-01 | 0.948 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.210661e-01 | 0.917 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.343473e-01 | 0.872 |
| R-HSA-70171 | Glycolysis | 1.844825e-01 | 0.734 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.844825e-01 | 0.734 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.308619e-01 | 0.883 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.525268e-01 | 0.817 |
| R-HSA-162582 | Signal Transduction | 1.911617e-01 | 0.719 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.916312e-01 | 0.718 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.496547e-01 | 0.825 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.901252e-01 | 0.721 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.706339e-01 | 0.768 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.360444e-01 | 0.866 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.901252e-01 | 0.721 |
| R-HSA-5663205 | Infectious disease | 1.038532e-01 | 0.984 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.997166e-01 | 0.700 |
| R-HSA-381042 | PERK regulates gene expression | 1.081400e-01 | 0.966 |
| R-HSA-114608 | Platelet degranulation | 1.222615e-01 | 0.913 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.553725e-01 | 0.809 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.210661e-01 | 0.917 |
| R-HSA-1483255 | PI Metabolism | 1.911392e-01 | 0.719 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.480825e-01 | 0.829 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.916312e-01 | 0.718 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.617893e-01 | 0.791 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.124062e-01 | 0.949 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.384586e-01 | 0.859 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.220543e-01 | 0.913 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.124062e-01 | 0.949 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.210714e-01 | 0.917 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.254561e-01 | 0.902 |
| R-HSA-6807070 | PTEN Regulation | 1.554661e-01 | 0.808 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.433753e-01 | 0.844 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.752387e-01 | 0.756 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.027378e-01 | 0.988 |
| R-HSA-73928 | Depyrimidination | 1.433753e-01 | 0.844 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.698370e-01 | 0.770 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.039188e-01 | 0.983 |
| R-HSA-5619084 | ABC transporter disorders | 1.078915e-01 | 0.967 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.989769e-01 | 0.701 |
| R-HSA-4086400 | PCP/CE pathway | 1.078915e-01 | 0.967 |
| R-HSA-202424 | Downstream TCR signaling | 1.460161e-01 | 0.836 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.844825e-01 | 0.734 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.869158e-01 | 0.728 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.889513e-01 | 0.724 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.554661e-01 | 0.808 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.045340e-01 | 0.689 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.078648e-01 | 0.682 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.093642e-01 | 0.679 |
| R-HSA-75893 | TNF signaling | 2.093642e-01 | 0.679 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.128558e-01 | 0.672 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.128558e-01 | 0.672 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.128558e-01 | 0.672 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.154934e-01 | 0.667 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.182342e-01 | 0.661 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.190584e-01 | 0.659 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.232592e-01 | 0.651 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.232592e-01 | 0.651 |
| R-HSA-171007 | p38MAPK events | 2.232592e-01 | 0.651 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.232592e-01 | 0.651 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.232592e-01 | 0.651 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.232592e-01 | 0.651 |
| R-HSA-8876725 | Protein methylation | 2.232592e-01 | 0.651 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.232592e-01 | 0.651 |
| R-HSA-73942 | DNA Damage Reversal | 2.232592e-01 | 0.651 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.239201e-01 | 0.650 |
| R-HSA-186712 | Regulation of beta-cell development | 2.239201e-01 | 0.650 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.287309e-01 | 0.641 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 2.287901e-01 | 0.641 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 2.287901e-01 | 0.641 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 2.287901e-01 | 0.641 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 2.287901e-01 | 0.641 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 2.287901e-01 | 0.641 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.335258e-01 | 0.632 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 2.335258e-01 | 0.632 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.335258e-01 | 0.632 |
| R-HSA-71262 | Carnitine synthesis | 2.335258e-01 | 0.632 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.336674e-01 | 0.631 |
| R-HSA-8956321 | Nucleotide salvage | 2.336674e-01 | 0.631 |
| R-HSA-597592 | Post-translational protein modification | 2.343779e-01 | 0.630 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.357151e-01 | 0.628 |
| R-HSA-1266738 | Developmental Biology | 2.382498e-01 | 0.623 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.385508e-01 | 0.622 |
| R-HSA-9679506 | SARS-CoV Infections | 2.386408e-01 | 0.622 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.434395e-01 | 0.614 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.434395e-01 | 0.614 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.436572e-01 | 0.613 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.436572e-01 | 0.613 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.436572e-01 | 0.613 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.436572e-01 | 0.613 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 2.436572e-01 | 0.613 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.436572e-01 | 0.613 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.436572e-01 | 0.613 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.443067e-01 | 0.612 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.454622e-01 | 0.610 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.462604e-01 | 0.609 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.471698e-01 | 0.607 |
| R-HSA-70326 | Glucose metabolism | 2.533317e-01 | 0.596 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.536553e-01 | 0.596 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.536553e-01 | 0.596 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.536553e-01 | 0.596 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.536553e-01 | 0.596 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.536553e-01 | 0.596 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.581270e-01 | 0.588 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.586942e-01 | 0.587 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.635219e-01 | 0.579 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.635219e-01 | 0.579 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.635219e-01 | 0.579 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.635219e-01 | 0.579 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.635219e-01 | 0.579 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 2.635219e-01 | 0.579 |
| R-HSA-3928664 | Ephrin signaling | 2.635219e-01 | 0.579 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.635219e-01 | 0.579 |
| R-HSA-73886 | Chromosome Maintenance | 2.675588e-01 | 0.573 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.675588e-01 | 0.573 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.728272e-01 | 0.564 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.732587e-01 | 0.563 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.732587e-01 | 0.563 |
| R-HSA-9834899 | Specification of the neural plate border | 2.732587e-01 | 0.563 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.732587e-01 | 0.563 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.732587e-01 | 0.563 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.732587e-01 | 0.563 |
| R-HSA-392517 | Rap1 signalling | 2.732587e-01 | 0.563 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.732587e-01 | 0.563 |
| R-HSA-9675108 | Nervous system development | 2.826797e-01 | 0.549 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.828673e-01 | 0.548 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.828673e-01 | 0.548 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.828673e-01 | 0.548 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.828673e-01 | 0.548 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.828673e-01 | 0.548 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.828673e-01 | 0.548 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.828673e-01 | 0.548 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.828673e-01 | 0.548 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.829762e-01 | 0.548 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.922462e-01 | 0.534 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.923495e-01 | 0.534 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.923495e-01 | 0.534 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.923495e-01 | 0.534 |
| R-HSA-2161541 | Abacavir metabolism | 2.923495e-01 | 0.534 |
| R-HSA-167044 | Signalling to RAS | 2.923495e-01 | 0.534 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.924075e-01 | 0.534 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.968014e-01 | 0.528 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.017068e-01 | 0.520 |
| R-HSA-9755088 | Ribavirin ADME | 3.017068e-01 | 0.520 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.017068e-01 | 0.520 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.017068e-01 | 0.520 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.017068e-01 | 0.520 |
| R-HSA-380287 | Centrosome maturation | 3.021748e-01 | 0.520 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.070501e-01 | 0.513 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 3.109411e-01 | 0.507 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.109411e-01 | 0.507 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.109411e-01 | 0.507 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.109411e-01 | 0.507 |
| R-HSA-68877 | Mitotic Prometaphase | 3.116540e-01 | 0.506 |
| R-HSA-9909396 | Circadian clock | 3.143051e-01 | 0.503 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 3.167806e-01 | 0.499 |
| R-HSA-1643685 | Disease | 3.172416e-01 | 0.499 |
| R-HSA-3000170 | Syndecan interactions | 3.200537e-01 | 0.495 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.200537e-01 | 0.495 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.264799e-01 | 0.486 |
| R-HSA-429947 | Deadenylation of mRNA | 3.290464e-01 | 0.483 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.290464e-01 | 0.483 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.379207e-01 | 0.471 |
| R-HSA-420029 | Tight junction interactions | 3.379207e-01 | 0.471 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.379207e-01 | 0.471 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.379207e-01 | 0.471 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.379207e-01 | 0.471 |
| R-HSA-9830364 | Formation of the nephric duct | 3.379207e-01 | 0.471 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.379207e-01 | 0.471 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.385480e-01 | 0.470 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.395988e-01 | 0.469 |
| R-HSA-422475 | Axon guidance | 3.398301e-01 | 0.469 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.457649e-01 | 0.461 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.466782e-01 | 0.460 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.466782e-01 | 0.460 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.466782e-01 | 0.460 |
| R-HSA-2161522 | Abacavir ADME | 3.466782e-01 | 0.460 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.466782e-01 | 0.460 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.466782e-01 | 0.460 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.504918e-01 | 0.455 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.505591e-01 | 0.455 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.553204e-01 | 0.449 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.553204e-01 | 0.449 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.553204e-01 | 0.449 |
| R-HSA-8949613 | Cristae formation | 3.553204e-01 | 0.449 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.553204e-01 | 0.449 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.553204e-01 | 0.449 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.553204e-01 | 0.449 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.553204e-01 | 0.449 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.553414e-01 | 0.449 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.601113e-01 | 0.444 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.601113e-01 | 0.444 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.638488e-01 | 0.439 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.638488e-01 | 0.439 |
| R-HSA-73614 | Pyrimidine salvage | 3.638488e-01 | 0.439 |
| R-HSA-5620971 | Pyroptosis | 3.638488e-01 | 0.439 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.696117e-01 | 0.432 |
| R-HSA-156902 | Peptide chain elongation | 3.696117e-01 | 0.432 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.722649e-01 | 0.429 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.722649e-01 | 0.429 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.722649e-01 | 0.429 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.722649e-01 | 0.429 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.722649e-01 | 0.429 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.790565e-01 | 0.421 |
| R-HSA-73884 | Base Excision Repair | 3.790565e-01 | 0.421 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.805701e-01 | 0.420 |
| R-HSA-2424491 | DAP12 signaling | 3.805701e-01 | 0.420 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.805701e-01 | 0.420 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.805701e-01 | 0.420 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.805701e-01 | 0.420 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.805701e-01 | 0.420 |
| R-HSA-112311 | Neurotransmitter clearance | 3.805701e-01 | 0.420 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.805701e-01 | 0.420 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.837569e-01 | 0.416 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.863462e-01 | 0.413 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.884421e-01 | 0.411 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.884421e-01 | 0.411 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.887660e-01 | 0.410 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.887660e-01 | 0.410 |
| R-HSA-72766 | Translation | 3.904692e-01 | 0.408 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.921444e-01 | 0.407 |
| R-HSA-73894 | DNA Repair | 3.929074e-01 | 0.406 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.931116e-01 | 0.405 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.968539e-01 | 0.401 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.968539e-01 | 0.401 |
| R-HSA-69190 | DNA strand elongation | 3.968539e-01 | 0.401 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.968539e-01 | 0.401 |
| R-HSA-8951664 | Neddylation | 3.984316e-01 | 0.400 |
| R-HSA-73887 | Death Receptor Signaling | 4.005946e-01 | 0.397 |
| R-HSA-392499 | Metabolism of proteins | 4.007597e-01 | 0.397 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.048353e-01 | 0.393 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.048353e-01 | 0.393 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.048353e-01 | 0.393 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.048353e-01 | 0.393 |
| R-HSA-9930044 | Nuclear RNA decay | 4.048353e-01 | 0.393 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.048353e-01 | 0.393 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.048353e-01 | 0.393 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.048353e-01 | 0.393 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.048353e-01 | 0.393 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.048353e-01 | 0.393 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.048353e-01 | 0.393 |
| R-HSA-9733709 | Cardiogenesis | 4.048353e-01 | 0.393 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.048353e-01 | 0.393 |
| R-HSA-354192 | Integrin signaling | 4.048353e-01 | 0.393 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.070222e-01 | 0.390 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.078380e-01 | 0.390 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.116252e-01 | 0.385 |
| R-HSA-390522 | Striated Muscle Contraction | 4.127116e-01 | 0.384 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.127116e-01 | 0.384 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.127116e-01 | 0.384 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.127116e-01 | 0.384 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.127116e-01 | 0.384 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.127116e-01 | 0.384 |
| R-HSA-9711097 | Cellular response to starvation | 4.147513e-01 | 0.382 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.204841e-01 | 0.376 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.204841e-01 | 0.376 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.204841e-01 | 0.376 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.204841e-01 | 0.376 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.204841e-01 | 0.376 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.227835e-01 | 0.374 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.253276e-01 | 0.371 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.253276e-01 | 0.371 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.253276e-01 | 0.371 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.281543e-01 | 0.368 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.281543e-01 | 0.368 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.281543e-01 | 0.368 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 4.281543e-01 | 0.368 |
| R-HSA-187687 | Signalling to ERKs | 4.281543e-01 | 0.368 |
| R-HSA-72312 | rRNA processing | 4.310515e-01 | 0.365 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.343704e-01 | 0.362 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.357234e-01 | 0.361 |
| R-HSA-3371511 | HSF1 activation | 4.357234e-01 | 0.361 |
| R-HSA-111933 | Calmodulin induced events | 4.357234e-01 | 0.361 |
| R-HSA-111997 | CaM pathway | 4.357234e-01 | 0.361 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.357234e-01 | 0.361 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.357234e-01 | 0.361 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.357234e-01 | 0.361 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.357829e-01 | 0.361 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.388633e-01 | 0.358 |
| R-HSA-15869 | Metabolism of nucleotides | 4.428044e-01 | 0.354 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.431927e-01 | 0.353 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.431927e-01 | 0.353 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.431927e-01 | 0.353 |
| R-HSA-192823 | Viral mRNA Translation | 4.477905e-01 | 0.349 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.505637e-01 | 0.346 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.522244e-01 | 0.345 |
| R-HSA-9833110 | RSV-host interactions | 4.566381e-01 | 0.340 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.578375e-01 | 0.339 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.578375e-01 | 0.339 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.578375e-01 | 0.339 |
| R-HSA-72306 | tRNA processing | 4.599586e-01 | 0.337 |
| R-HSA-3371568 | Attenuation phase | 4.650154e-01 | 0.333 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.650154e-01 | 0.333 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.650154e-01 | 0.333 |
| R-HSA-167169 | HIV Transcription Elongation | 4.650154e-01 | 0.333 |
| R-HSA-9646399 | Aggrephagy | 4.650154e-01 | 0.333 |
| R-HSA-202433 | Generation of second messenger molecules | 4.650154e-01 | 0.333 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.654039e-01 | 0.332 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.697555e-01 | 0.328 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.720988e-01 | 0.326 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.735758e-01 | 0.325 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.740861e-01 | 0.324 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.769559e-01 | 0.322 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.783954e-01 | 0.320 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.790888e-01 | 0.320 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.790888e-01 | 0.320 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.790888e-01 | 0.320 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.790888e-01 | 0.320 |
| R-HSA-111996 | Ca-dependent events | 4.859867e-01 | 0.313 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.859867e-01 | 0.313 |
| R-HSA-611105 | Respiratory electron transport | 4.870359e-01 | 0.312 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.911936e-01 | 0.309 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.911936e-01 | 0.309 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.927937e-01 | 0.307 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.954158e-01 | 0.305 |
| R-HSA-2172127 | DAP12 interactions | 4.995109e-01 | 0.301 |
| R-HSA-5683826 | Surfactant metabolism | 4.995109e-01 | 0.301 |
| R-HSA-109582 | Hemostasis | 5.057964e-01 | 0.296 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.061396e-01 | 0.296 |
| R-HSA-774815 | Nucleosome assembly | 5.061396e-01 | 0.296 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.061396e-01 | 0.296 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.061396e-01 | 0.296 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.079488e-01 | 0.294 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.079488e-01 | 0.294 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.126809e-01 | 0.290 |
| R-HSA-9675135 | Diseases of DNA repair | 5.126809e-01 | 0.290 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.126809e-01 | 0.290 |
| R-HSA-373760 | L1CAM interactions | 5.161912e-01 | 0.287 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.191360e-01 | 0.285 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.202782e-01 | 0.284 |
| R-HSA-70263 | Gluconeogenesis | 5.255059e-01 | 0.279 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.255059e-01 | 0.279 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.283832e-01 | 0.277 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.283832e-01 | 0.277 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.363953e-01 | 0.271 |
| R-HSA-9748787 | Azathioprine ADME | 5.379950e-01 | 0.269 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.403664e-01 | 0.267 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.403664e-01 | 0.267 |
| R-HSA-9864848 | Complex IV assembly | 5.441162e-01 | 0.264 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 5.441162e-01 | 0.264 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.501568e-01 | 0.260 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.501568e-01 | 0.260 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.501568e-01 | 0.260 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.561176e-01 | 0.255 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.561176e-01 | 0.255 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.561176e-01 | 0.255 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.561176e-01 | 0.255 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.619999e-01 | 0.250 |
| R-HSA-9753281 | Paracetamol ADME | 5.678045e-01 | 0.246 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.735326e-01 | 0.241 |
| R-HSA-177929 | Signaling by EGFR | 5.735326e-01 | 0.241 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.735326e-01 | 0.241 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.735326e-01 | 0.241 |
| R-HSA-5621480 | Dectin-2 family | 5.791851e-01 | 0.237 |
| R-HSA-1483166 | Synthesis of PA | 5.791851e-01 | 0.237 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.791851e-01 | 0.237 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.847631e-01 | 0.233 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.847631e-01 | 0.233 |
| R-HSA-983189 | Kinesins | 5.956991e-01 | 0.225 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.956991e-01 | 0.225 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.956991e-01 | 0.225 |
| R-HSA-156590 | Glutathione conjugation | 5.956991e-01 | 0.225 |
| R-HSA-450294 | MAP kinase activation | 6.010592e-01 | 0.221 |
| R-HSA-112043 | PLC beta mediated events | 6.010592e-01 | 0.221 |
| R-HSA-1483257 | Phospholipid metabolism | 6.042118e-01 | 0.219 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.063485e-01 | 0.217 |
| R-HSA-1268020 | Mitochondrial protein import | 6.063485e-01 | 0.217 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.077832e-01 | 0.216 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.084649e-01 | 0.216 |
| R-HSA-373755 | Semaphorin interactions | 6.115680e-01 | 0.214 |
| R-HSA-9748784 | Drug ADME | 6.141299e-01 | 0.212 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.167186e-01 | 0.210 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.172885e-01 | 0.210 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.182648e-01 | 0.209 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.182648e-01 | 0.209 |
| R-HSA-9664407 | Parasite infection | 6.182648e-01 | 0.209 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.217107e-01 | 0.206 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.218012e-01 | 0.206 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.268168e-01 | 0.203 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.317661e-01 | 0.199 |
| R-HSA-112040 | G-protein mediated events | 6.317661e-01 | 0.199 |
| R-HSA-9830369 | Kidney development | 6.317661e-01 | 0.199 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.319051e-01 | 0.199 |
| R-HSA-167172 | Transcription of the HIV genome | 6.366501e-01 | 0.196 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.366501e-01 | 0.196 |
| R-HSA-448424 | Interleukin-17 signaling | 6.462255e-01 | 0.190 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.509186e-01 | 0.186 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.548600e-01 | 0.184 |
| R-HSA-74259 | Purine catabolism | 6.555497e-01 | 0.183 |
| R-HSA-4086398 | Ca2+ pathway | 6.601197e-01 | 0.180 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.601197e-01 | 0.180 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.612062e-01 | 0.180 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.635190e-01 | 0.178 |
| R-HSA-9609507 | Protein localization | 6.643443e-01 | 0.178 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.646293e-01 | 0.177 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.646293e-01 | 0.177 |
| R-HSA-8852135 | Protein ubiquitination | 6.690794e-01 | 0.175 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.690794e-01 | 0.175 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.690794e-01 | 0.175 |
| R-HSA-1989781 | PPARA activates gene expression | 6.705504e-01 | 0.174 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.766639e-01 | 0.170 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.778039e-01 | 0.169 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.820800e-01 | 0.166 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.820800e-01 | 0.166 |
| R-HSA-9659379 | Sensory processing of sound | 6.862995e-01 | 0.163 |
| R-HSA-9833482 | PKR-mediated signaling | 6.904633e-01 | 0.161 |
| R-HSA-6806834 | Signaling by MET | 6.904633e-01 | 0.161 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.026275e-01 | 0.153 |
| R-HSA-5619102 | SLC transporter disorders | 7.058611e-01 | 0.151 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.084828e-01 | 0.150 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.104715e-01 | 0.148 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.143159e-01 | 0.146 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.143159e-01 | 0.146 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.181095e-01 | 0.144 |
| R-HSA-70268 | Pyruvate metabolism | 7.218529e-01 | 0.142 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.218529e-01 | 0.142 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.432969e-01 | 0.129 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.432969e-01 | 0.129 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.467073e-01 | 0.127 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.533935e-01 | 0.123 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.599040e-01 | 0.119 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.599040e-01 | 0.119 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.630948e-01 | 0.117 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.646753e-01 | 0.117 |
| R-HSA-9658195 | Leishmania infection | 7.646753e-01 | 0.117 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.662434e-01 | 0.116 |
| R-HSA-5617833 | Cilium Assembly | 7.670645e-01 | 0.115 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.693503e-01 | 0.114 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.716316e-01 | 0.113 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.784266e-01 | 0.109 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.842791e-01 | 0.106 |
| R-HSA-111885 | Opioid Signalling | 7.842791e-01 | 0.106 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.976125e-01 | 0.098 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.982459e-01 | 0.098 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 8.009293e-01 | 0.096 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.087682e-01 | 0.092 |
| R-HSA-397014 | Muscle contraction | 8.150613e-01 | 0.089 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.162999e-01 | 0.088 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.169336e-01 | 0.088 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.211562e-01 | 0.086 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.211562e-01 | 0.086 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.258847e-01 | 0.083 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.282021e-01 | 0.082 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.349717e-01 | 0.078 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.393366e-01 | 0.076 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.414757e-01 | 0.075 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.422268e-01 | 0.075 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.477245e-01 | 0.072 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.517536e-01 | 0.070 |
| R-HSA-8956319 | Nucleotide catabolism | 8.537282e-01 | 0.069 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.556765e-01 | 0.068 |
| R-HSA-9843745 | Adipogenesis | 8.594961e-01 | 0.066 |
| R-HSA-166520 | Signaling by NTRKs | 8.911188e-01 | 0.050 |
| R-HSA-112316 | Neuronal System | 8.917318e-01 | 0.050 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.073284e-01 | 0.042 |
| R-HSA-382551 | Transport of small molecules | 9.205900e-01 | 0.036 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.232274e-01 | 0.035 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.232274e-01 | 0.035 |
| R-HSA-983712 | Ion channel transport | 9.380986e-01 | 0.028 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.435584e-01 | 0.025 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.487368e-01 | 0.023 |
| R-HSA-6805567 | Keratinization | 9.514272e-01 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.533696e-01 | 0.021 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.552014e-01 | 0.020 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.688814e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.759062e-01 | 0.011 |
| R-HSA-416476 | G alpha (q) signalling events | 9.778049e-01 | 0.010 |
| R-HSA-5668914 | Diseases of metabolism | 9.830007e-01 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 9.910507e-01 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 9.968641e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.985503e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.993602e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.994514e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999614e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999751e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
JNK2 |
0.676 | 0.175 | 1 | 0.784 |
JNK3 |
0.674 | 0.168 | 1 | 0.804 |
CAMKK2 |
0.674 | 0.217 | -2 | 0.507 |
CAMKK1 |
0.671 | 0.268 | -2 | 0.514 |
GAK |
0.670 | 0.015 | 1 | 0.753 |
P38B |
0.669 | 0.164 | 1 | 0.808 |
P38D |
0.668 | 0.185 | 1 | 0.750 |
MOS |
0.668 | 0.013 | 1 | 0.803 |
NLK |
0.668 | 0.219 | 1 | 0.857 |
LKB1 |
0.668 | 0.077 | -3 | 0.182 |
P38A |
0.666 | 0.153 | 1 | 0.836 |
ERK5 |
0.665 | 0.170 | 1 | 0.858 |
ALK2 |
0.665 | 0.022 | -2 | 0.508 |
PRP4 |
0.664 | 0.030 | -3 | 0.072 |
BRAF |
0.663 | 0.004 | -4 | 0.500 |
VRK2 |
0.663 | -0.052 | 1 | 0.782 |
TGFBR1 |
0.662 | 0.023 | -2 | 0.483 |
BMPR1B |
0.662 | 0.011 | 1 | 0.735 |
LATS1 |
0.662 | -0.049 | -3 | 0.073 |
ALK4 |
0.662 | -0.019 | -2 | 0.477 |
BMPR2 |
0.662 | -0.118 | -2 | 0.494 |
PRPK |
0.660 | -0.013 | -1 | 0.786 |
PINK1 |
0.660 | 0.184 | 1 | 0.782 |
MEK1 |
0.660 | -0.056 | 2 | 0.830 |
ATR |
0.659 | 0.015 | 1 | 0.735 |
ACVR2B |
0.659 | -0.015 | -2 | 0.467 |
DYRK2 |
0.658 | 0.120 | 1 | 0.827 |
TAK1 |
0.658 | -0.037 | 1 | 0.698 |
P38G |
0.657 | 0.149 | 1 | 0.737 |
DAPK2 |
0.657 | -0.078 | -3 | 0.111 |
NEK5 |
0.657 | 0.035 | 1 | 0.702 |
ICK |
0.657 | 0.006 | -3 | 0.107 |
JNK1 |
0.657 | 0.143 | 1 | 0.776 |
PASK |
0.655 | -0.046 | -3 | 0.083 |
NIK |
0.655 | -0.111 | -3 | 0.107 |
SBK |
0.655 | -0.000 | -3 | 0.041 |
HIPK1 |
0.655 | 0.081 | 1 | 0.830 |
CDK8 |
0.655 | 0.182 | 1 | 0.803 |
CDKL1 |
0.654 | -0.043 | -3 | 0.088 |
MST2 |
0.654 | -0.079 | 1 | 0.697 |
BIKE |
0.654 | 0.058 | 1 | 0.650 |
PKR |
0.654 | -0.073 | 1 | 0.728 |
LRRK2 |
0.654 | -0.047 | 2 | 0.819 |
BMPR1A |
0.654 | 0.003 | 1 | 0.709 |
CAMLCK |
0.654 | -0.082 | -2 | 0.440 |
ERK1 |
0.653 | 0.153 | 1 | 0.795 |
CAMK1B |
0.653 | -0.076 | -3 | 0.101 |
NEK1 |
0.653 | 0.050 | 1 | 0.671 |
NEK9 |
0.652 | 0.198 | 2 | 0.813 |
PBK |
0.652 | -0.004 | 1 | 0.688 |
ACVR2A |
0.652 | -0.036 | -2 | 0.451 |
MPSK1 |
0.651 | -0.012 | 1 | 0.697 |
GCK |
0.651 | -0.091 | 1 | 0.698 |
DSTYK |
0.651 | 0.061 | 2 | 0.866 |
MAK |
0.651 | 0.041 | -2 | 0.382 |
PDHK4 |
0.650 | -0.019 | 1 | 0.759 |
DLK |
0.649 | -0.129 | 1 | 0.715 |
HIPK4 |
0.649 | 0.074 | 1 | 0.827 |
CHK1 |
0.649 | -0.039 | -3 | 0.103 |
NEK4 |
0.649 | 0.067 | 1 | 0.670 |
RAF1 |
0.648 | -0.033 | 1 | 0.726 |
CDC7 |
0.648 | 0.031 | 1 | 0.774 |
CLK3 |
0.648 | 0.026 | 1 | 0.864 |
ERK2 |
0.648 | 0.132 | 1 | 0.814 |
HIPK3 |
0.648 | 0.095 | 1 | 0.813 |
MEKK1 |
0.648 | -0.042 | 1 | 0.682 |
MEK5 |
0.648 | -0.153 | 2 | 0.806 |
ANKRD3 |
0.647 | -0.106 | 1 | 0.725 |
YSK4 |
0.647 | -0.073 | 1 | 0.653 |
DYRK1B |
0.647 | 0.093 | 1 | 0.796 |
CK1D |
0.647 | -0.042 | -3 | 0.028 |
MEK2 |
0.647 | 0.007 | 2 | 0.800 |
NEK11 |
0.647 | -0.029 | 1 | 0.669 |
CDK1 |
0.647 | 0.125 | 1 | 0.796 |
MEKK2 |
0.647 | -0.121 | 2 | 0.783 |
DYRK1A |
0.646 | 0.059 | 1 | 0.832 |
MINK |
0.646 | -0.070 | 1 | 0.675 |
AAK1 |
0.646 | 0.056 | 1 | 0.571 |
DYRK4 |
0.646 | 0.129 | 1 | 0.791 |
CDK19 |
0.646 | 0.174 | 1 | 0.783 |
SMMLCK |
0.645 | -0.086 | -3 | 0.101 |
MOK |
0.645 | 0.037 | 1 | 0.828 |
PDK1 |
0.645 | -0.102 | 1 | 0.672 |
ALPHAK3 |
0.645 | -0.049 | -1 | 0.745 |
CAMK2G |
0.645 | -0.018 | 2 | 0.799 |
MST1 |
0.645 | -0.111 | 1 | 0.675 |
TNIK |
0.645 | -0.078 | 3 | 0.829 |
GRK7 |
0.645 | -0.053 | 1 | 0.685 |
MEKK3 |
0.644 | -0.110 | 1 | 0.686 |
MASTL |
0.644 | -0.084 | -2 | 0.448 |
PDHK1 |
0.644 | -0.012 | 1 | 0.736 |
SKMLCK |
0.644 | -0.099 | -2 | 0.448 |
HPK1 |
0.644 | -0.072 | 1 | 0.683 |
CDKL5 |
0.643 | -0.012 | -3 | 0.088 |
GRK6 |
0.643 | -0.040 | 1 | 0.735 |
COT |
0.643 | -0.076 | 2 | 0.858 |
CLK4 |
0.643 | 0.006 | -3 | 0.074 |
VRK1 |
0.643 | -0.140 | 2 | 0.814 |
GRK5 |
0.642 | -0.108 | -3 | 0.095 |
NEK8 |
0.642 | -0.044 | 2 | 0.783 |
TLK1 |
0.642 | -0.075 | -2 | 0.501 |
MLK2 |
0.642 | -0.068 | 2 | 0.805 |
DAPK3 |
0.642 | -0.097 | -3 | 0.072 |
CHAK2 |
0.642 | -0.018 | -1 | 0.758 |
ULK1 |
0.642 | 0.360 | -3 | 0.375 |
EEF2K |
0.642 | -0.077 | 3 | 0.770 |
GRK2 |
0.642 | -0.049 | -2 | 0.422 |
HGK |
0.642 | -0.074 | 3 | 0.827 |
PLK1 |
0.641 | -0.023 | -2 | 0.430 |
DMPK1 |
0.641 | -0.087 | -3 | 0.056 |
GRK1 |
0.641 | -0.008 | -2 | 0.458 |
PRKD1 |
0.641 | 0.042 | -3 | 0.103 |
HIPK2 |
0.640 | 0.101 | 1 | 0.775 |
NEK2 |
0.640 | 0.053 | 2 | 0.785 |
SMG1 |
0.640 | 0.021 | 1 | 0.688 |
DYRK3 |
0.640 | 0.045 | 1 | 0.818 |
MAP3K15 |
0.640 | -0.105 | 1 | 0.635 |
PERK |
0.640 | -0.071 | -2 | 0.502 |
TAO3 |
0.640 | -0.141 | 1 | 0.686 |
TAO2 |
0.640 | -0.117 | 2 | 0.814 |
CDK5 |
0.639 | 0.112 | 1 | 0.825 |
ULK2 |
0.639 | 0.244 | 2 | 0.767 |
CDK17 |
0.639 | 0.140 | 1 | 0.737 |
CAMK2D |
0.639 | -0.018 | -3 | 0.116 |
SRPK3 |
0.639 | -0.011 | -3 | 0.069 |
TLK2 |
0.639 | -0.097 | 1 | 0.674 |
KHS1 |
0.639 | -0.087 | 1 | 0.674 |
PKN3 |
0.639 | -0.020 | -3 | 0.167 |
ATM |
0.639 | 0.001 | 1 | 0.669 |
CDK13 |
0.638 | 0.137 | 1 | 0.799 |
CDK14 |
0.638 | 0.120 | 1 | 0.793 |
MTOR |
0.638 | -0.014 | 1 | 0.741 |
DNAPK |
0.638 | 0.022 | 1 | 0.612 |
MST3 |
0.638 | -0.112 | 2 | 0.808 |
MEKK6 |
0.637 | -0.116 | 1 | 0.687 |
PIM1 |
0.637 | -0.075 | -3 | 0.059 |
TTK |
0.637 | -0.127 | -2 | 0.456 |
HUNK |
0.637 | -0.005 | 2 | 0.817 |
CDK7 |
0.637 | 0.120 | 1 | 0.818 |
CK1A2 |
0.637 | -0.054 | -3 | 0.026 |
CRIK |
0.637 | -0.065 | -3 | 0.059 |
PIM3 |
0.637 | -0.090 | -3 | 0.068 |
SRPK1 |
0.636 | 0.002 | -3 | 0.056 |
ASK1 |
0.636 | -0.104 | 1 | 0.623 |
CDK9 |
0.636 | 0.141 | 1 | 0.801 |
HRI |
0.636 | -0.075 | -2 | 0.485 |
CDK18 |
0.636 | 0.125 | 1 | 0.773 |
MAPKAPK3 |
0.636 | -0.029 | -3 | 0.084 |
DAPK1 |
0.636 | -0.089 | -3 | 0.071 |
CLK1 |
0.636 | 0.013 | -3 | 0.071 |
NEK7 |
0.636 | 0.003 | -3 | 0.176 |
OSR1 |
0.635 | -0.146 | 2 | 0.786 |
NUAK2 |
0.635 | -0.061 | -3 | 0.111 |
KIS |
0.635 | 0.138 | 1 | 0.823 |
PIM2 |
0.635 | -0.072 | -3 | 0.072 |
KHS2 |
0.634 | -0.090 | 1 | 0.690 |
ROCK2 |
0.634 | -0.106 | -3 | 0.065 |
CLK2 |
0.634 | 0.036 | -3 | 0.053 |
NEK3 |
0.634 | 0.067 | 1 | 0.635 |
TSSK2 |
0.633 | -0.097 | -5 | 0.500 |
CDK12 |
0.633 | 0.125 | 1 | 0.780 |
CDK16 |
0.632 | 0.119 | 1 | 0.750 |
MYO3B |
0.632 | -0.060 | 2 | 0.792 |
P70S6KB |
0.632 | -0.087 | -3 | 0.078 |
MARK4 |
0.632 | -0.041 | 4 | 0.828 |
CK1E |
0.632 | -0.056 | -3 | 0.030 |
ZAK |
0.632 | -0.141 | 1 | 0.647 |
DCAMKL1 |
0.631 | -0.095 | -3 | 0.074 |
NEK6 |
0.631 | -0.016 | -2 | 0.490 |
CHK2 |
0.630 | -0.063 | -3 | 0.052 |
CDK2 |
0.630 | 0.082 | 1 | 0.822 |
GSK3A |
0.630 | 0.034 | 4 | 0.544 |
MLK1 |
0.630 | -0.130 | 2 | 0.777 |
AMPKA1 |
0.630 | -0.102 | -3 | 0.096 |
PLK2 |
0.630 | -0.026 | -3 | 0.108 |
STLK3 |
0.629 | -0.134 | 1 | 0.620 |
CAMK2B |
0.629 | -0.020 | 2 | 0.788 |
CAMK2A |
0.629 | -0.023 | 2 | 0.788 |
BUB1 |
0.629 | -0.042 | -5 | 0.500 |
MYO3A |
0.629 | -0.090 | 1 | 0.666 |
PLK3 |
0.629 | -0.048 | 2 | 0.767 |
CAMK1D |
0.629 | -0.080 | -3 | 0.049 |
MAPKAPK2 |
0.629 | -0.016 | -3 | 0.054 |
CDK10 |
0.629 | 0.105 | 1 | 0.785 |
TGFBR2 |
0.629 | -0.072 | -2 | 0.463 |
YSK1 |
0.629 | -0.098 | 2 | 0.777 |
PRKD3 |
0.629 | -0.044 | -3 | 0.078 |
IKKE |
0.629 | 0.009 | 1 | 0.616 |
IKKA |
0.628 | -0.044 | -2 | 0.429 |
LOK |
0.628 | -0.098 | -2 | 0.410 |
GSK3B |
0.628 | 0.027 | 4 | 0.535 |
CDK6 |
0.628 | 0.120 | 1 | 0.777 |
RIPK1 |
0.628 | -0.117 | 1 | 0.676 |
GRK3 |
0.628 | -0.053 | -2 | 0.403 |
PRKD2 |
0.628 | -0.008 | -3 | 0.077 |
AKT2 |
0.627 | -0.076 | -3 | 0.057 |
TBK1 |
0.627 | -0.056 | 1 | 0.620 |
WNK1 |
0.627 | -0.113 | -2 | 0.450 |
P90RSK |
0.627 | -0.062 | -3 | 0.084 |
CDK3 |
0.627 | 0.109 | 1 | 0.755 |
MYLK4 |
0.627 | -0.089 | -2 | 0.385 |
RIPK3 |
0.626 | -0.083 | 3 | 0.760 |
TSSK1 |
0.626 | -0.085 | -3 | 0.096 |
GRK4 |
0.626 | -0.099 | -2 | 0.480 |
MRCKA |
0.626 | -0.102 | -3 | 0.065 |
SGK1 |
0.626 | -0.079 | -3 | 0.035 |
BMPR2_TYR |
0.626 | 0.043 | -1 | 0.854 |
IKKB |
0.626 | -0.069 | -2 | 0.427 |
SRPK2 |
0.625 | -0.009 | -3 | 0.056 |
CDK4 |
0.625 | 0.107 | 1 | 0.774 |
ERK7 |
0.625 | 0.033 | 2 | 0.505 |
PDHK3_TYR |
0.624 | -0.041 | 4 | 0.886 |
WNK4 |
0.624 | -0.115 | -2 | 0.454 |
LATS2 |
0.624 | -0.068 | -5 | 0.500 |
SLK |
0.624 | -0.118 | -2 | 0.367 |
RSK2 |
0.623 | -0.077 | -3 | 0.056 |
CHAK1 |
0.623 | -0.039 | 2 | 0.769 |
DRAK1 |
0.623 | -0.049 | 1 | 0.652 |
MRCKB |
0.623 | -0.098 | -3 | 0.066 |
MAPKAPK5 |
0.623 | -0.012 | -3 | 0.126 |
AMPKA2 |
0.623 | -0.103 | -3 | 0.080 |
MAP2K6_TYR |
0.623 | -0.015 | -1 | 0.831 |
ROCK1 |
0.622 | -0.108 | -3 | 0.064 |
MAP2K4_TYR |
0.622 | -0.008 | -1 | 0.807 |
PKN2 |
0.621 | -0.107 | -3 | 0.097 |
PDHK1_TYR |
0.621 | -0.029 | -1 | 0.842 |
CAMK1A |
0.621 | -0.068 | -3 | 0.051 |
MSK1 |
0.621 | -0.073 | -3 | 0.070 |
IRAK1 |
0.620 | -0.025 | -1 | 0.637 |
SGK3 |
0.620 | -0.107 | -3 | 0.064 |
CAMK4 |
0.620 | -0.120 | -3 | 0.103 |
DCAMKL2 |
0.620 | -0.106 | -3 | 0.083 |
MLK3 |
0.619 | -0.088 | 2 | 0.702 |
NDR1 |
0.619 | -0.119 | -3 | 0.076 |
NDR2 |
0.619 | -0.088 | -3 | 0.068 |
MLK4 |
0.619 | -0.115 | 2 | 0.691 |
MST4 |
0.619 | -0.091 | 2 | 0.824 |
MARK2 |
0.619 | -0.027 | 4 | 0.734 |
CAMK1G |
0.619 | -0.069 | -3 | 0.107 |
CK2A2 |
0.619 | 0.031 | 1 | 0.684 |
PDHK4_TYR |
0.618 | -0.071 | 2 | 0.871 |
RSK4 |
0.618 | -0.075 | -3 | 0.059 |
QSK |
0.618 | -0.053 | 4 | 0.794 |
WNK3 |
0.617 | -0.123 | 1 | 0.690 |
IRAK4 |
0.617 | -0.074 | 1 | 0.669 |
TTBK2 |
0.616 | -0.120 | 2 | 0.699 |
BCKDK |
0.616 | -0.052 | -1 | 0.704 |
MARK1 |
0.615 | -0.042 | 4 | 0.777 |
PKCD |
0.615 | -0.124 | 2 | 0.746 |
MELK |
0.615 | -0.114 | -3 | 0.082 |
GCN2 |
0.615 | -0.065 | 2 | 0.792 |
RSK3 |
0.615 | -0.081 | -3 | 0.079 |
P70S6K |
0.614 | -0.080 | -3 | 0.081 |
PKMYT1_TYR |
0.614 | -0.058 | 3 | 0.853 |
TESK1_TYR |
0.614 | -0.101 | 3 | 0.868 |
QIK |
0.614 | -0.104 | -3 | 0.113 |
MSK2 |
0.614 | -0.094 | -3 | 0.067 |
PKACB |
0.614 | -0.081 | -2 | 0.298 |
AURB |
0.614 | -0.076 | -2 | 0.282 |
PAK1 |
0.613 | -0.120 | -2 | 0.368 |
PKACG |
0.613 | -0.104 | -2 | 0.346 |
NUAK1 |
0.613 | -0.078 | -3 | 0.098 |
HASPIN |
0.613 | -0.074 | -1 | 0.606 |
NIM1 |
0.612 | -0.062 | 3 | 0.782 |
MARK3 |
0.612 | -0.042 | 4 | 0.761 |
EPHA6 |
0.612 | 0.009 | -1 | 0.834 |
AKT1 |
0.611 | -0.094 | -3 | 0.055 |
AURC |
0.611 | -0.062 | -2 | 0.292 |
PAK2 |
0.611 | -0.135 | -2 | 0.358 |
SIK |
0.611 | -0.076 | -3 | 0.086 |
PAK3 |
0.610 | -0.116 | -2 | 0.375 |
MAP2K7_TYR |
0.610 | -0.194 | 2 | 0.846 |
AURA |
0.610 | -0.076 | -2 | 0.269 |
SSTK |
0.609 | -0.084 | 4 | 0.780 |
TAO1 |
0.609 | -0.139 | 1 | 0.603 |
RIPK2 |
0.609 | -0.096 | 1 | 0.600 |
CK2A1 |
0.608 | 0.016 | 1 | 0.664 |
PKACA |
0.608 | -0.084 | -2 | 0.266 |
CK1G3 |
0.608 | -0.077 | -3 | 0.008 |
CK1A |
0.607 | -0.049 | -3 | 0.013 |
EPHB4 |
0.607 | -0.049 | -1 | 0.782 |
PKCZ |
0.607 | -0.122 | 2 | 0.747 |
EPHA4 |
0.606 | -0.019 | 2 | 0.773 |
PKCA |
0.605 | -0.098 | 2 | 0.684 |
PINK1_TYR |
0.604 | -0.172 | 1 | 0.740 |
LIMK2_TYR |
0.604 | -0.103 | -3 | 0.100 |
PKCB |
0.604 | -0.108 | 2 | 0.691 |
AKT3 |
0.604 | -0.084 | -3 | 0.039 |
PKG2 |
0.603 | -0.107 | -2 | 0.293 |
PRKX |
0.603 | -0.071 | -3 | 0.030 |
PTK2 |
0.603 | 0.051 | -1 | 0.827 |
IRE2 |
0.603 | -0.121 | 2 | 0.707 |
SYK |
0.603 | 0.004 | -1 | 0.819 |
IRE1 |
0.603 | -0.138 | 1 | 0.673 |
STK33 |
0.602 | -0.065 | 2 | 0.615 |
FAM20C |
0.602 | 0.014 | 2 | 0.630 |
CK1G2 |
0.602 | -0.051 | -3 | 0.018 |
PKCH |
0.602 | -0.128 | 2 | 0.676 |
FER |
0.601 | -0.075 | 1 | 0.782 |
FGR |
0.601 | -0.098 | 1 | 0.758 |
SRMS |
0.601 | -0.039 | 1 | 0.757 |
BRSK1 |
0.600 | -0.084 | -3 | 0.090 |
EPHB2 |
0.600 | -0.037 | -1 | 0.765 |
PKCI |
0.600 | -0.081 | 2 | 0.701 |
TXK |
0.600 | -0.066 | 1 | 0.766 |
MNK2 |
0.599 | -0.114 | -2 | 0.369 |
PKCG |
0.599 | -0.122 | 2 | 0.692 |
EPHB3 |
0.599 | -0.043 | -1 | 0.765 |
MNK1 |
0.599 | -0.125 | -2 | 0.373 |
DDR1 |
0.599 | -0.113 | 4 | 0.807 |
BLK |
0.599 | -0.022 | -1 | 0.781 |
EPHB1 |
0.598 | -0.059 | 1 | 0.744 |
LIMK1_TYR |
0.598 | -0.163 | 2 | 0.831 |
ABL2 |
0.598 | -0.060 | -1 | 0.718 |
PLK4 |
0.597 | -0.127 | 2 | 0.629 |
HCK |
0.597 | -0.053 | -1 | 0.757 |
JAK2 |
0.597 | -0.106 | 1 | 0.685 |
LCK |
0.596 | -0.050 | -1 | 0.774 |
SNRK |
0.596 | -0.106 | 2 | 0.664 |
INSRR |
0.596 | -0.086 | 3 | 0.750 |
JAK3 |
0.596 | -0.092 | 1 | 0.662 |
TYK2 |
0.596 | -0.125 | 1 | 0.681 |
RET |
0.596 | -0.177 | 1 | 0.687 |
CK1G1 |
0.595 | -0.091 | -3 | 0.020 |
BRSK2 |
0.595 | -0.107 | -3 | 0.095 |
PAK6 |
0.595 | -0.055 | -2 | 0.311 |
FYN |
0.594 | -0.040 | -1 | 0.763 |
PKCE |
0.594 | -0.108 | 2 | 0.676 |
PHKG1 |
0.594 | -0.124 | -3 | 0.076 |
TNK2 |
0.594 | -0.064 | 3 | 0.790 |
ABL1 |
0.594 | -0.061 | -1 | 0.696 |
MST1R |
0.594 | -0.150 | 3 | 0.820 |
TTBK1 |
0.593 | -0.096 | 2 | 0.615 |
YES1 |
0.593 | -0.110 | -1 | 0.734 |
PKN1 |
0.593 | -0.093 | -3 | 0.085 |
CSF1R |
0.592 | -0.132 | 3 | 0.808 |
ROS1 |
0.592 | -0.143 | 3 | 0.771 |
EPHA3 |
0.591 | -0.051 | 2 | 0.746 |
FLT1 |
0.591 | -0.088 | -1 | 0.825 |
KIT |
0.589 | -0.119 | 3 | 0.809 |
EPHA7 |
0.589 | -0.051 | 2 | 0.771 |
TYRO3 |
0.589 | -0.173 | 3 | 0.794 |
FGFR2 |
0.589 | -0.126 | 3 | 0.804 |
MET |
0.589 | -0.115 | 3 | 0.806 |
ITK |
0.588 | -0.106 | -1 | 0.710 |
TEK |
0.588 | -0.076 | 3 | 0.740 |
NTRK1 |
0.588 | -0.079 | -1 | 0.740 |
PKCT |
0.588 | -0.139 | 2 | 0.688 |
JAK1 |
0.587 | -0.031 | 1 | 0.620 |
EPHA5 |
0.587 | -0.045 | 2 | 0.760 |
EPHA8 |
0.586 | -0.051 | -1 | 0.781 |
BMX |
0.585 | -0.077 | -1 | 0.651 |
KDR |
0.585 | -0.130 | 3 | 0.776 |
LYN |
0.585 | -0.068 | 3 | 0.725 |
FGFR1 |
0.585 | -0.099 | 3 | 0.776 |
TNNI3K_TYR |
0.585 | -0.085 | 1 | 0.721 |
ERBB2 |
0.584 | -0.094 | 1 | 0.648 |
FGFR3 |
0.584 | -0.105 | 3 | 0.777 |
PAK5 |
0.583 | -0.088 | -2 | 0.275 |
NEK10_TYR |
0.583 | -0.085 | 1 | 0.569 |
FLT3 |
0.582 | -0.133 | 3 | 0.792 |
EGFR |
0.582 | -0.066 | 1 | 0.564 |
YANK3 |
0.582 | -0.069 | 2 | 0.416 |
SRC |
0.582 | -0.081 | -1 | 0.727 |
MERTK |
0.581 | -0.107 | 3 | 0.797 |
BTK |
0.581 | -0.118 | -1 | 0.642 |
PTK2B |
0.580 | -0.059 | -1 | 0.642 |
NTRK3 |
0.580 | -0.104 | -1 | 0.708 |
PDGFRB |
0.580 | -0.163 | 3 | 0.808 |
FRK |
0.580 | -0.091 | -1 | 0.772 |
DDR2 |
0.580 | -0.102 | 3 | 0.745 |
TEC |
0.580 | -0.100 | -1 | 0.609 |
FLT4 |
0.579 | -0.099 | 3 | 0.765 |
EPHA2 |
0.578 | -0.044 | -1 | 0.764 |
INSR |
0.578 | -0.103 | 3 | 0.728 |
PDGFRA |
0.578 | -0.133 | 3 | 0.804 |
NTRK2 |
0.577 | -0.117 | 3 | 0.765 |
PHKG2 |
0.577 | -0.116 | -3 | 0.093 |
ERBB4 |
0.577 | -0.048 | 1 | 0.605 |
MATK |
0.577 | -0.112 | -1 | 0.657 |
PAK4 |
0.576 | -0.074 | -2 | 0.281 |
LTK |
0.576 | -0.109 | 3 | 0.753 |
ALK |
0.576 | -0.117 | 3 | 0.723 |
EPHA1 |
0.576 | -0.105 | 3 | 0.783 |
AXL |
0.576 | -0.152 | 3 | 0.796 |
ZAP70 |
0.576 | -0.049 | -1 | 0.730 |
FGFR4 |
0.575 | -0.091 | -1 | 0.717 |
TNK1 |
0.575 | -0.146 | 3 | 0.785 |
PTK6 |
0.575 | -0.162 | -1 | 0.614 |
PKG1 |
0.575 | -0.106 | -2 | 0.240 |
CSK |
0.574 | -0.114 | 2 | 0.772 |
YANK2 |
0.573 | -0.080 | 2 | 0.428 |
WEE1_TYR |
0.572 | -0.115 | -1 | 0.651 |
IGF1R |
0.568 | -0.096 | 3 | 0.669 |
MUSK |
0.562 | -0.074 | 1 | 0.547 |
FES |
0.560 | -0.071 | -1 | 0.608 |