Motif 1218 (n=293)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S3 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A1A5D9 | BICDL2 | S3 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A6NMY6 | ANXA2P2 | T3 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| C9JAW5 | None | T3 | ochoa | HIG1 domain-containing protein | None |
| C9JLW8 | MCRIP1 | S3 | ochoa | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}. |
| F2Z307 | ATP6V1G2-DDX39B | S3 | ochoa | V-type proton ATPase subunit G | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. {ECO:0000256|RuleBase:RU364019}. |
| H3BQ06 | None | S3 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. {ECO:0000256|ARBA:ARBA00046245}. |
| O00762 | UBE2C | S3 | ochoa | Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| O14613 | CDC42EP2 | T3 | ochoa | Cdc42 effector protein 2 (Binder of Rho GTPases 1) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| O14734 | ACOT8 | S3 | ochoa | Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:15194431, PubMed:9153233, PubMed:9299485). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9153233, PubMed:9299485). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). {ECO:0000250|UniProtKB:P58137, ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}.; FUNCTION: (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). {ECO:0000269|PubMed:9153233}. |
| O14907 | TAX1BP3 | Y3 | ochoa | Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) | May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}. |
| O15020 | SPTBN2 | S3 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15037 | KHNYN | T3 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15156 | ZBTB7B | S3 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15254 | ACOX3 | S3 | ochoa | Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) | Oxidizes the CoA-esters of 2-methyl-branched fatty acids. {ECO:0000250|UniProtKB:Q63448}. |
| O15294 | OGT | S3 | ochoa|psp | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:26237509, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:34667079, ECO:0000269|PubMed:37541260, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085). {ECO:0000269|PubMed:31527085}. |
| O15400 | STX7 | Y3 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43264 | ZW10 | S3 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| O43399 | TPD52L2 | S3 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43491 | EPB41L2 | T3 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43760 | SYNGR2 | S3 | ochoa | Synaptogyrin-2 (Cellugyrin) | May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}.; FUNCTION: (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}. |
| O60220 | TIMM8A | S3 | ochoa | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
| O60264 | SMARCA5 | S3 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60503 | ADCY9 | S3 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60662 | KLHL41 | S3 | ochoa | Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}. |
| O60678 | PRMT3 | S3 | ochoa | Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) | Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566, PubMed:39513743). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:22795084). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (PubMed:25728001, PubMed:31378783, PubMed:39513743). Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783). {ECO:0000250|UniProtKB:Q922H1, ECO:0000269|PubMed:22795084, ECO:0000269|PubMed:23445220, ECO:0000269|PubMed:25728001, ECO:0000269|PubMed:31378783, ECO:0000269|PubMed:33495566, ECO:0000269|PubMed:39513743}. |
| O60684 | KPNA6 | T3 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O60739 | EIF1B | T3 | ochoa | Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20) | Probably involved in translation. |
| O60762 | DPM1 | S3 | ochoa | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. {ECO:0000269|PubMed:10835346}. |
| O75348 | ATP6V1G1 | S3 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75381 | PEX14 | S3 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75531 | BANF1 | T3 | ochoa|psp | Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] | Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32792394). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (PubMed:32792394). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (PubMed:31796734). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (PubMed:25991860). In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication (PubMed:18005698). {ECO:0000269|PubMed:10908652, ECO:0000269|PubMed:11792822, ECO:0000269|PubMed:12163470, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:25991860, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394, ECO:0000269|PubMed:9465049}.; FUNCTION: (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome (PubMed:11005805, PubMed:16680152, PubMed:9465049). EMD and BAF are cooperative cofactors of HIV-1 infection (PubMed:16680152). Association of EMD with the viral DNA requires the presence of BAF and viral integrase (PubMed:16680152). The association of viral DNA with chromatin requires the presence of BAF and EMD (PubMed:16680152). {ECO:0000269|PubMed:11005805, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:9465049}. |
| O75694 | NUP155 | S3 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O75821 | EIF3G | T3 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O76094 | SRP72 | S3 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O95070 | YIF1A | Y3 | ochoa | Protein YIF1A (54TMp) (YIP1-interacting factor homolog A) | Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000269|PubMed:15990086}. |
| O95232 | LUC7L3 | S3 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95238 | SPDEF | S3 | ochoa | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
| O95379 | TNFAIP8 | S3 | ochoa | Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}. |
| O95670 | ATP6V1G2 | S3 | ochoa | V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. {ECO:0000250|UniProtKB:O75348}. |
| O95777 | LSM8 | S3 | ochoa | U6 snRNA-associated Sm-like protein LSm8 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| O96007 | MOCS2 | S3 | ochoa | Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit) | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}. |
| P00338 | LDHA | T3 | psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00352 | ALDH1A1 | S3 | ochoa | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
| P00492 | HPRT1 | T3 | ochoa | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| P04075 | ALDOA | Y3 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05386 | RPLP1 | S3 | ochoa | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | Plays an important role in the elongation step of protein synthesis. |
| P05387 | RPLP2 | Y3 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P06730 | EIF4E | T3 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07355 | ANXA2 | T3 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08651 | NFIC | S3 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08670 | VIM | T3 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09914 | IFIT1 | T3 | ochoa | Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1) | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486). {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:28251928, ECO:0000269|PubMed:36285486, ECO:0000269|PubMed:39009378}. |
| P11474 | ESRRA | S3 | ochoa | Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}. |
| P11836 | MS4A1 | T3 | ochoa | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
| P14621 | ACYP2 | T3 | ochoa | Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2) | Its physiological role is not yet clear. |
| P15121 | AKR1B1 | S3 | ochoa | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| P16152 | CBR1 | S3 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P16885 | PLCG2 | T3 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P16949 | STMN1 | S3 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P19484 | TFEB | S3 | psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20339 | RAB5A | S3 | ochoa | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P20340 | RAB6A | T3 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P22234 | PAICS | T3 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P22307 | SCP2 | S3 | ochoa | Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X) | [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:10706581}.; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (PubMed:17157249, PubMed:7642518, PubMed:8300590). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:7642518, ECO:0000269|PubMed:8300590}. |
| P23528 | CFL1 | S3 | ochoa|psp | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}. |
| P24844 | MYL9 | S3 | psp | Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}. |
| P25788 | PSMA3 | S3 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P27707 | DCK | T3 | ochoa|psp | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P29401 | TKT | S3 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P31321 | PRKAR1B | S3 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
| P33991 | MCM4 | S3 | ochoa|psp | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35222 | CTNNB1 | T3 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35520 | CBS | S3 | ochoa | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P35548 | MSX2 | S3 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P35568 | IRS1 | S3 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P37837 | TALDO1 | S3 | ochoa | Transaldolase (EC 2.2.1.2) | Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}. |
| P40121 | CAPG | T3 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P41182 | BCL6 | S3 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P41220 | RGS2 | S3 | psp | Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). {ECO:0000250|UniProtKB:O08849, ECO:0000269|PubMed:11063746, ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:19736320, ECO:0000269|PubMed:28784619, ECO:0000305|PubMed:7643615}. |
| P41743 | PRKCI | T3 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P42025 | ACTR1B | S3 | ochoa | Beta-centractin (Actin-related protein 1B) (ARP1B) | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| P42858 | HTT | T3 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46734 | MAP2K3 | S3 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P46821 | MAP1B | T3 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47974 | ZFP36L2 | T3 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48426 | PIP4K2A | T3 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}. |
| P48643 | CCT5 | S3 | ochoa | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49189 | ALDH9A1 | T3 | ochoa | 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] | Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}. |
| P49356 | FNTB | S3 | ochoa | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}. |
| P49721 | PSMB2 | Y3 | ochoa | Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P49790 | NUP153 | S3 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49902 | NT5C2 | T3 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P49959 | MRE11 | T3 | ochoa | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50151 | GNG10 | S3 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. |
| P50548 | ERF | T3 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P50851 | LRBA | S3 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51397 | DAP | S3 | ochoa|psp | Death-associated protein 1 (DAP-1) | Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}. |
| P51532 | SMARCA4 | T3 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51610 | HCFC1 | S3 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51659 | HSD17B4 | S3 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P51911 | CNN1 | S3 | ochoa | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. |
| P52292 | KPNA2 | T3 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P52294 | KPNA1 | T3 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P53611 | RABGGTB | T3 | ochoa | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}. |
| P55055 | NR1H2 | S3 | ochoa | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}. |
| P55072 | VCP | S3 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56134 | ATP5MF | S3 | ochoa | ATP synthase F(0) complex subunit f, mitochondrial (ATP synthase membrane subunit f) | Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P56524 | HDAC4 | S3 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P59768 | GNG2 | S3 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}. |
| P60981 | DSTN | S3 | ochoa|psp | Destrin (Actin-depolymerizing factor) (ADF) | Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}. |
| P61163 | ACTR1A | S3 | ochoa | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| P61289 | PSME3 | S3 | ochoa | Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. |
| P61978 | HNRNPK | T3 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P62249 | RPS16 | S3 | ochoa | Small ribosomal subunit protein uS9 (40S ribosomal protein S16) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62820 | RAB1A | S3 | ochoa | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}. |
| P67809 | YBX1 | S3 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P67870 | CSNK2B | S3 | ochoa|psp | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}. |
| P78371 | CCT2 | S3 | ochoa|psp | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P84022 | SMAD3 | S3 | ochoa | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| P98179 | RBM3 | S3 | ochoa | RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL) | Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}. |
| Q00341 | HDLBP | S3 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00839 | HNRNPU | S3 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q01658 | DR1 | S3 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q04864 | REL | S3 | ochoa | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q05329 | GAD2 | S3 | psp | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) | Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}. |
| Q07065 | CKAP4 | S3 | psp | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| Q07108 | CD69 | S3 | ochoa | Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69) | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481). {ECO:0000250|UniProtKB:P37217, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:26296369, ECO:0000269|PubMed:34841721, ECO:0000269|PubMed:35930205, ECO:0000269|PubMed:37039481}. |
| Q08AG7 | MZT1 | S3 | ochoa | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q0VGL1 | LAMTOR4 | S3 | ochoa | Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed] | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). {ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}. |
| Q13077 | TRAF1 | S3 | ochoa | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
| Q13451 | FKBP5 | T3 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q13464 | ROCK1 | T3 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13542 | EIF4EBP2 | S3 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13596 | SNX1 | S3 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13601 | KRR1 | S3 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13616 | CUL1 | S3 | ochoa | Cullin-1 (CUL-1) | Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:22017875, PubMed:22017877, PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1 (PubMed:12609982, PubMed:38326650). The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component (PubMed:38326650). SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25503564, PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Neddylated CUL1-RBX1 ubiquitinates p53/TP53 recruited by Cul7-RING(FBXW8) complex (PubMed:35982156). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). The SCF(FBXO31) protein ligase complex specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress (PubMed:39880951). {ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:35982156, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39880951, ECO:0000269|PubMed:9663463}. |
| Q13671 | RIN1 | S3 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14004 | CDK13 | S3 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14123 | PDE1C | S3 | ochoa | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) | Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}. |
| Q14938 | NFIX | S3 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15020 | SART3 | T3 | ochoa | Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}. |
| Q15172 | PPP2R5A | S3 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15637 | SF1 | T3 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q15796 | SMAD2 | S3 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q15836 | VAMP3 | T3 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q15847 | ADIRF | S3 | ochoa | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}. |
| Q16186 | ADRM1 | T3 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q16513 | PKN2 | S3 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16576 | RBBP7 | S3 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16877 | PFKFB4 | S3 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. |
| Q17RC7 | EXOC3L4 | S3 | ochoa | Exocyst complex component 3-like protein 4 | None |
| Q2Q1W2 | TRIM71 | S3 | psp | E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250|UniProtKB:Q1PSW8, ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:28431233, ECO:0000305|PubMed:24239284}. |
| Q32MZ4 | LRRFIP1 | S3 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q53GA4 | PHLDA2 | S3 | ochoa | Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C) | Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}. |
| Q53T59 | HS1BP3 | S3 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5BKX5 | ACTMAP | S3 | ochoa | Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) | Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}. |
| Q5JSH3 | WDR44 | S3 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5RL73 | RBM48 | S3 | ochoa | RNA-binding protein 48 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000305|PubMed:33509932}. |
| Q5SSJ5 | HP1BP3 | T3 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T0W9 | FAM83B | T3 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T4S7 | UBR4 | T3 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T7W7 | TSTD2 | S3 | ochoa | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) | None |
| Q6DD88 | ATL3 | S3 | ochoa | Atlastin-3 (AT3) (ATL-3) (EC 3.6.5.-) | Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:24459106, PubMed:27619977, PubMed:37102997). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:37102997}. |
| Q6NSJ2 | PHLDB3 | T3 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6P1A2 | LPCAT3 | S3 | ochoa | Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) | Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18195019, PubMed:18772128, PubMed:18782225). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18195019, PubMed:18772128, PubMed:18782225). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250|UniProtKB:Q91V01, ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225}. |
| Q6P2E9 | EDC4 | S3 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P589 | TNFAIP8L2 | S3 | psp | Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20) | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). {ECO:0000250|UniProtKB:Q9D8Y7, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32188758, ECO:0000269|PubMed:32460619}. |
| Q6PKG0 | LARP1 | T3 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q7KZF4 | SND1 | S3 | ochoa | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q7KZI7 | MARK2 | S3 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7LFL8 | CXXC5 | S3 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7Z591 | AKNA | S3 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z614 | SNX20 | S3 | ochoa | Sorting nexin-20 (Selectin ligand-interactor cytoplasmic 1) (SLIC-1) | May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. {ECO:0000305|PubMed:18196517}. |
| Q86TI2 | DPP9 | T3 | ochoa | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36112693, ECO:0000269|PubMed:36357533}. |
| Q86VP1 | TAX1BP1 | S3 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VP6 | CAND1 | S3 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86WA8 | LONP2 | S3 | ochoa | Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon) | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}. |
| Q86Y82 | STX12 | Y3 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q8IWZ3 | ANKHD1 | T3 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N0S6 | CENPL | S3 | ochoa | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}. |
| Q8N165 | PDIK1L | S3 | ochoa | Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) | None |
| Q8N302 | AGGF1 | S3 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3J5 | PPM1K | T3 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8N461 | FBXL16 | S3 | ochoa | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q8N4Y2 | CRACR2B | S3 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8NA72 | POC5 | S3 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
| Q8NEL9 | DDHD1 | Y3 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8TBE7 | SLC35G2 | T3 | ochoa | Solute carrier family 35 member G2 (Transmembrane protein 22) | None |
| Q8TBZ6 | TRMT10A | S3 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
| Q8TCY9 | URGCP | S3 | ochoa | Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) | May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. |
| Q8TDB6 | DTX3L | S3 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8TDP1 | RNASEH2C | S3 | ochoa | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| Q8TEU7 | RAPGEF6 | S3 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WTW3 | COG1 | T3 | ochoa | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | Required for normal Golgi function. {ECO:0000250}. |
| Q8WUX9 | CHMP7 | S3 | psp | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Q8WVV9 | HNRNPLL | S3 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q8WXH0 | SYNE2 | S3 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92621 | NUP205 | T3 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
| Q92890 | UFD1 | S3 | ochoa | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| Q969T4 | UBE2E3 | S3 | ochoa | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| Q96AJ9 | VTI1A | S3 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Q96B49 | TOMM6 | S3 | ochoa | Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog) | None |
| Q96BD8 | SKA1 | S3 | ochoa | SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) | Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (PubMed:17093495, PubMed:19289083, PubMed:22371557, PubMed:22483620, PubMed:23085020, PubMed:26981768, PubMed:27697923, PubMed:29487209, PubMed:31804178). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:28479321, PubMed:29487209). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17093495, PubMed:19289083, PubMed:23085020, PubMed:28479321, PubMed:29487209). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (PubMed:19289083, PubMed:22371557, PubMed:22454517, PubMed:23085020, PubMed:24413531, PubMed:27697923, PubMed:28479321, PubMed:28495837, PubMed:29487209). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (PubMed:23085020, PubMed:29153323). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (PubMed:26981768). In the complex, it mediates interactions with microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:24413531, PubMed:27667719, PubMed:29153323, PubMed:36592928). It also stimulates AURKB/Aurora B catalytic activity (PubMed:27697923). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q9CPV1, ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:22371557, ECO:0000269|PubMed:22454517, ECO:0000269|PubMed:22483620, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:24413531, ECO:0000269|PubMed:26981768, ECO:0000269|PubMed:27667719, ECO:0000269|PubMed:27697923, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:28495837, ECO:0000269|PubMed:29153323, ECO:0000269|PubMed:29487209, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:36592928}. |
| Q96C00 | ZBTB9 | T3 | ochoa | Zinc finger and BTB domain-containing protein 9 | May be involved in transcriptional regulation. |
| Q96C19 | EFHD2 | T3 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96C55 | ZNF524 | T3 | ochoa | Zinc finger protein 524 | May be involved in transcriptional regulation. |
| Q96CN4 | EVI5L | S3 | ochoa | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| Q96DF8 | ESS2 | T3 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96HR3 | MED30 | T3 | ochoa | Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}. |
| Q96LT7 | C9orf72 | T3 | ochoa | Guanine nucleotide exchange factor C9orf72 | Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531, PubMed:37821429). Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy (PubMed:37821429). Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Promotes initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to CFL1/cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q6DFW0, ECO:0000269|PubMed:24549040, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27334615, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:27723745, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654, ECO:0000269|PubMed:37821429}.; FUNCTION: [Isoform 1]: Regulates stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}.; FUNCTION: [Isoform 2]: Does not play a role in regulation of stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}. |
| Q96MH2 | HEXIM2 | T4 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96S21 | RAB40C | S3 | ochoa | Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}. |
| Q96S90 | LYSMD1 | S3 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q99439 | CNN2 | S3 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99594 | TEAD3 | S3 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99622 | C12orf57 | S3 | ochoa | Protein C10 | In brain, may be required for corpus callosum development. {ECO:0000269|PubMed:23453666}. |
| Q99848 | EBNA1BP2 | T3 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q99865 | SPIN2A | T3 | ochoa | Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A) | May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000250|UniProtKB:Q9BPZ2, ECO:0000269|PubMed:29061846}. |
| Q9BPY3 | FAM118B | S3 | ochoa | Protein FAM118B | May play a role in Cajal bodies formation. {ECO:0000269|PubMed:24569877}. |
| Q9BPZ2 | SPIN2B | T3 | ochoa | Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) | Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000269|PubMed:12145692, ECO:0000269|PubMed:29061846}. |
| Q9BQG0 | MYBBP1A | S3 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BQJ4 | TMEM47 | S3 | ochoa | Transmembrane protein 47 (Brain cell membrane protein 1) (Transmembrane 4 superfamily member 10) | Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). {ECO:0000250|UniProtKB:Q9JJG6, ECO:0000250|UniProtKB:Q9XSV3}. |
| Q9BRZ2 | TRIM56 | S3 | ochoa | E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160, ECO:0000269|PubMed:29426904, ECO:0000269|PubMed:31251739, ECO:0000269|PubMed:35952808}. |
| Q9BSM1 | PCGF1 | S3 | ochoa | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}. |
| Q9BVC4 | MLST8 | T3 | ochoa | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) | Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}. |
| Q9BWQ6 | YIPF2 | S3 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9BXP2 | SLC12A9 | S3 | ochoa | Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) | May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (PubMed:10871601). May play a role in lysosomal ion flux and osmoregulation (PubMed:38334070). {ECO:0000269|PubMed:10871601, ECO:0000269|PubMed:38334070}. |
| Q9BY11 | PACSIN1 | S3 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9BZE0 | GLIS2 | S3 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9GZX7 | AICDA | S3 | psp | Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase) | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}. |
| Q9H0L4 | CSTF2T | S3 | ochoa | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9H190 | SDCBP2 | S3 | ochoa | Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2) | Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). {ECO:0000269|PubMed:15961997}. |
| Q9H1K6 | TLNRD1 | S3 | ochoa | Talin rod domain-containing protein 1 (Mesoderm development candidate 1) | Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. {ECO:0000269|PubMed:22179486}. |
| Q9H2U1 | DHX36 | Y3 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H410 | DSN1 | S3 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H4A4 | RNPEP | S3 | ochoa | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| Q9H583 | HEATR1 | S3 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H6Q4 | CIAO3 | S3 | ochoa | Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}. |
| Q9H840 | GEMIN7 | T3 | ochoa | Gem-associated protein 7 (Gemin-7) (SIP3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}. |
| Q9H875 | PRKRIP1 | S3 | ochoa | PRKR-interacting protein 1 | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| Q9H9Z2 | LIN28A | S3 | ochoa | Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1) | RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:22118463, ECO:0000269|PubMed:22898984, ECO:0000305}. |
| Q9HA47 | UCK1 | S3 | ochoa | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
| Q9HB71 | CACYBP | S3 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HBI1 | PARVB | S3 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9HCD5 | NCOA5 | T3 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NP77 | SSU72 | S3 | ochoa|psp | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) | Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}. |
| Q9NPJ3 | ACOT13 | S3 | ochoa | Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed] | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQR4, ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545}. |
| Q9NQG5 | RPRD1B | S3 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NS56 | TOPORS | S3 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NUP7 | TRMT13 | T3 | ochoa | tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) | tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}. |
| Q9NVD7 | PARVA | T3 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NVH1 | DNAJC11 | T3 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NVT9 | ARMC1 | S3 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NWA0 | MED9 | S3 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9NWS9 | ZNF446 | S3 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NXH3 | PPP1R14D | S3 | ochoa | Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) | Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}. |
| Q9NYJ1 | COA4 | T3 | ochoa | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein) | Putative COX assembly factor. {ECO:0000250}. |
| Q9NYL2 | MAP3K20 | S3 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P0K8 | FOXJ2 | S3 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
| Q9P0L0 | VAPA | S3 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P1Q0 | VPS54 | S3 | ochoa | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q9P253 | VPS18 | S3 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9UBI6 | GNG12 | S3 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q9UBS8 | RNF14 | S3 | ochoa | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q9UEY8 | ADD3 | S3 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHD2 | TBK1 | S3 | ochoa | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UIM3 | FKBPL | T3 | ochoa | FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39) (WISp39) | May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. {ECO:0000269|PubMed:15664193}. |
| Q9UIU6 | SIX4 | S3 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UK76 | JPT1 | T3 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKK9 | NUDT5 | S3 | ochoa | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
| Q9ULP9 | TBC1D24 | S3 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9UM13 | ANAPC10 | T3 | ochoa | Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UNQ0 | ABCG2 | S3 | ochoa | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response. {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000269|PubMed:38181789, ECO:0000305|PubMed:12958161}. |
| Q9Y228 | TRAF3IP3 | S3 | ochoa | TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) | Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}. |
| Q9Y241 | HIGD1A | T3 | ochoa | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9Y281 | CFL2 | S3 | ochoa | Cofilin-2 (Cofilin, muscle isoform) | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}. |
| Q9Y284 | WDR83OS | T3 | ochoa | PAT complex subunit Asterix (Protein associated with the ER translocon of 10kDa) (PAT-10) (PAT10) (WD repeat domain 83 opposite strand) (WDR83 opposite strand) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:12475939, PubMed:32814900, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:32814900, PubMed:36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity). {ECO:0000250|UniProtKB:A0A8I3NQW8, ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:36261522}. |
| Q9Y291 | MRPS33 | S3 | ochoa | Small ribosomal subunit protein mS33 (28S ribosomal protein S33, mitochondrial) (MRP-S33) (S33mt) | None |
| Q9Y2J2 | EPB41L3 | T3 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2V2 | CARHSP1 | S3 | ochoa | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y4H2 | IRS2 | S3 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y530 | OARD1 | S3 | ochoa | ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-) | ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23474714, PubMed:23481255). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506). {ECO:0000269|PubMed:21849506, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255}. |
| Q9Y5M8 | SRPRB | S3 | ochoa | Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) | Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}. |
| Q9Y5S1 | TRPV2 | S3 | ochoa | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}. |
| S4R325 | URGCP-MRPS24 | S3 | ochoa | URGCP-MRPS24 readthrough | None |
| S4R3Y5 | MTRNR2L11 | T3 | ochoa | Humanin-like 11 (HN11) (MT-RNR2-like protein 11) | Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}. |
| P17029 | ZKSCAN1 | T3 | Sugiyama | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P53778 | MAPK12 | S3 | ELM|iPTMNet|EPSD|PSP | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
| P19474 | TRIM21 | S3 | Sugiyama | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) | E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 (PubMed:16297862, PubMed:16316627, PubMed:16472766, PubMed:16880511, PubMed:18022694, PubMed:18361920, PubMed:18641315, PubMed:18845142, PubMed:19675099, PubMed:26347139). Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination (PubMed:16880511, PubMed:19675099). Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes (PubMed:16880511). A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome (PubMed:16880511). Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling (PubMed:19675099). Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 (PubMed:18641315). Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway (PubMed:18022694). Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (By similarity). Plays a role in the regulation of the cell cycle progression (PubMed:16880511). Enhances the decapping activity of DCP2 (PubMed:18361920). Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules (PubMed:1985094, PubMed:8666824). At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified (PubMed:8666824). The common feature of these proteins is their ability to bind HY RNAs.2 (PubMed:8666824). Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:26347139). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:26347139). Also regulates autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability (PubMed:36359729). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464). During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation (PubMed:36426955). When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity (PubMed:29743353). Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly (PubMed:36692217). {ECO:0000250|UniProtKB:Q62191, ECO:0000269|PubMed:16297862, ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:16880511, ECO:0000269|PubMed:18022694, ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:18641315, ECO:0000269|PubMed:18845142, ECO:0000269|PubMed:19675099, ECO:0000269|PubMed:1985094, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:29743353, ECO:0000269|PubMed:36359729, ECO:0000269|PubMed:36426955, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:8666824}. |
| Q5S007 | LRRK2 | S3 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P61019 | RAB2A | Y3 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| Q8WUD1 | RAB2B | Y3 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8953897 | Cellular responses to stimuli | 1.913645e-07 | 6.718 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.725903e-06 | 5.429 |
| R-HSA-2262752 | Cellular responses to stress | 6.953580e-06 | 5.158 |
| R-HSA-68886 | M Phase | 1.386466e-04 | 3.858 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.742853e-04 | 3.759 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.505657e-04 | 3.601 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.709117e-04 | 3.567 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 3.035957e-04 | 3.518 |
| R-HSA-1640170 | Cell Cycle | 3.527722e-04 | 3.453 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.350882e-04 | 3.197 |
| R-HSA-68882 | Mitotic Anaphase | 5.216817e-04 | 3.283 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.434211e-04 | 3.265 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.954650e-04 | 3.225 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.337290e-04 | 3.363 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.293276e-04 | 3.201 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.405926e-04 | 3.356 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.776920e-04 | 3.169 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.954111e-04 | 3.099 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.036670e-03 | 2.984 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 1.863261e-03 | 2.730 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 1.863261e-03 | 2.730 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 1.863261e-03 | 2.730 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.640003e-03 | 2.785 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.935990e-03 | 2.713 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.722017e-03 | 2.764 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.608561e-03 | 2.794 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.487100e-03 | 2.828 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.972656e-03 | 2.705 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.789851e-03 | 2.747 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.492684e-03 | 2.826 |
| R-HSA-168256 | Immune System | 2.255437e-03 | 2.647 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.470199e-03 | 2.607 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.523355e-03 | 2.598 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.723263e-03 | 2.565 |
| R-HSA-9033241 | Peroxisomal protein import | 3.052404e-03 | 2.515 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.983615e-03 | 2.525 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.267317e-03 | 2.486 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.569936e-03 | 2.447 |
| R-HSA-9609507 | Protein localization | 3.504158e-03 | 2.455 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.519222e-03 | 2.454 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.771590e-03 | 2.423 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.357647e-03 | 2.361 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.249308e-03 | 2.372 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 4.274247e-03 | 2.369 |
| R-HSA-446728 | Cell junction organization | 4.390709e-03 | 2.357 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 6.512640e-03 | 2.186 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.821288e-03 | 2.235 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.275433e-03 | 2.202 |
| R-HSA-9634597 | GPER1 signaling | 6.753896e-03 | 2.170 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.684949e-03 | 2.175 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.684949e-03 | 2.175 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.390806e-03 | 2.268 |
| R-HSA-9796292 | Formation of axial mesoderm | 5.630158e-03 | 2.249 |
| R-HSA-9907900 | Proteasome assembly | 4.983324e-03 | 2.302 |
| R-HSA-391251 | Protein folding | 6.003441e-03 | 2.222 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.368946e-03 | 2.270 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.275433e-03 | 2.202 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.390806e-03 | 2.268 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.299274e-03 | 2.201 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.390806e-03 | 2.268 |
| R-HSA-6807070 | PTEN Regulation | 5.964024e-03 | 2.224 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.818244e-03 | 2.235 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.334476e-03 | 2.273 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.162909e-03 | 2.210 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 7.153330e-03 | 2.145 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 9.604625e-03 | 2.018 |
| R-HSA-74713 | IRS activation | 9.604625e-03 | 2.018 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 9.604625e-03 | 2.018 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 7.625163e-03 | 2.118 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 9.988243e-03 | 2.001 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 9.416698e-03 | 2.026 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.025492e-02 | 1.989 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 8.923738e-03 | 2.049 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 9.533316e-03 | 2.021 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 9.533316e-03 | 2.021 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.333141e-03 | 2.135 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 9.988243e-03 | 2.001 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.604625e-03 | 2.018 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 9.988243e-03 | 2.001 |
| R-HSA-68949 | Orc1 removal from chromatin | 8.923738e-03 | 2.049 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.287693e-03 | 2.032 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 9.533316e-03 | 2.021 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 7.153330e-03 | 2.145 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 9.604625e-03 | 2.018 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 8.341620e-03 | 2.079 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.017095e-02 | 1.993 |
| R-HSA-69306 | DNA Replication | 1.045242e-02 | 1.981 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.074327e-03 | 2.093 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.667919e-03 | 2.115 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.667919e-03 | 2.115 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.863663e-03 | 2.163 |
| R-HSA-917937 | Iron uptake and transport | 8.400159e-03 | 2.076 |
| R-HSA-449147 | Signaling by Interleukins | 9.470496e-03 | 2.024 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.083724e-02 | 1.965 |
| R-HSA-418597 | G alpha (z) signalling events | 1.083724e-02 | 1.965 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.237523e-02 | 1.907 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.273169e-02 | 1.895 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.207283e-02 | 1.918 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.207283e-02 | 1.918 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.153273e-02 | 1.938 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.237523e-02 | 1.907 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.305430e-02 | 1.884 |
| R-HSA-8951664 | Neddylation | 1.326242e-02 | 1.877 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.273169e-02 | 1.895 |
| R-HSA-111885 | Opioid Signalling | 1.110656e-02 | 1.954 |
| R-HSA-111933 | Calmodulin induced events | 1.305430e-02 | 1.884 |
| R-HSA-69239 | Synthesis of DNA | 1.317091e-02 | 1.880 |
| R-HSA-111997 | CaM pathway | 1.305430e-02 | 1.884 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.237523e-02 | 1.907 |
| R-HSA-1500931 | Cell-Cell communication | 1.179608e-02 | 1.928 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.408523e-02 | 1.851 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.586436e-02 | 1.800 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.424895e-02 | 1.846 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 1.424895e-02 | 1.846 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.545103e-02 | 1.811 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.471259e-02 | 1.832 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.424895e-02 | 1.846 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.546764e-02 | 1.811 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.579154e-02 | 1.802 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.541451e-02 | 1.812 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.600740e-02 | 1.796 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.629848e-02 | 1.788 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.629848e-02 | 1.788 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.629848e-02 | 1.788 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.881836e-02 | 1.725 |
| R-HSA-112412 | SOS-mediated signalling | 1.881836e-02 | 1.725 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.748223e-02 | 1.757 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.871825e-02 | 1.728 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.700326e-02 | 1.769 |
| R-HSA-202040 | G-protein activation | 1.757857e-02 | 1.755 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 1.757857e-02 | 1.755 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.871825e-02 | 1.728 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.748223e-02 | 1.757 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.871825e-02 | 1.728 |
| R-HSA-1632852 | Macroautophagy | 1.881429e-02 | 1.726 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.919490e-02 | 1.717 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.000714e-02 | 1.699 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.000714e-02 | 1.699 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.000714e-02 | 1.699 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.000714e-02 | 1.699 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.011803e-02 | 1.696 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.021107e-02 | 1.694 |
| R-HSA-991365 | Activation of GABAB receptors | 2.134944e-02 | 1.671 |
| R-HSA-977444 | GABA B receptor activation | 2.134944e-02 | 1.671 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.274566e-02 | 1.643 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.419625e-02 | 1.616 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.331759e-02 | 1.632 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.134944e-02 | 1.671 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.130498e-02 | 1.672 |
| R-HSA-111996 | Ca-dependent events | 2.134944e-02 | 1.671 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.130498e-02 | 1.672 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.256481e-02 | 1.647 |
| R-HSA-69242 | S Phase | 2.431159e-02 | 1.614 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.433390e-02 | 1.614 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.462538e-02 | 1.609 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.462538e-02 | 1.609 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.462538e-02 | 1.609 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.764154e-02 | 1.558 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.764154e-02 | 1.558 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.764154e-02 | 1.558 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.570162e-02 | 1.590 |
| R-HSA-774815 | Nucleosome assembly | 2.570162e-02 | 1.590 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.542983e-02 | 1.595 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.995241e-02 | 1.524 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.570162e-02 | 1.590 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.542983e-02 | 1.595 |
| R-HSA-9824272 | Somitogenesis | 2.570162e-02 | 1.590 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.571318e-02 | 1.590 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.704742e-02 | 1.568 |
| R-HSA-418990 | Adherens junctions interactions | 2.905040e-02 | 1.537 |
| R-HSA-421270 | Cell-cell junction organization | 2.823789e-02 | 1.549 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 2.637511e-02 | 1.579 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.570162e-02 | 1.590 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.570162e-02 | 1.590 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.570162e-02 | 1.590 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.961617e-02 | 1.528 |
| R-HSA-75153 | Apoptotic execution phase | 2.726215e-02 | 1.564 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.764154e-02 | 1.558 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.911196e-02 | 1.536 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.996816e-02 | 1.523 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 3.053929e-02 | 1.515 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 3.053929e-02 | 1.515 |
| R-HSA-198203 | PI3K/AKT activation | 3.053929e-02 | 1.515 |
| R-HSA-74749 | Signal attenuation | 3.053929e-02 | 1.515 |
| R-HSA-2586552 | Signaling by Leptin | 3.053929e-02 | 1.515 |
| R-HSA-9612973 | Autophagy | 3.084777e-02 | 1.511 |
| R-HSA-9766229 | Degradation of CDH1 | 3.227765e-02 | 1.491 |
| R-HSA-5689603 | UCH proteinases | 3.233385e-02 | 1.490 |
| R-HSA-9711097 | Cellular response to starvation | 3.265334e-02 | 1.486 |
| R-HSA-77387 | Insulin receptor recycling | 3.486988e-02 | 1.458 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 3.486988e-02 | 1.458 |
| R-HSA-68877 | Mitotic Prometaphase | 3.522625e-02 | 1.453 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 3.957921e-02 | 1.403 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 3.957921e-02 | 1.403 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 4.443207e-02 | 1.352 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 4.443207e-02 | 1.352 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 4.443207e-02 | 1.352 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 4.443207e-02 | 1.352 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 4.443207e-02 | 1.352 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.017749e-02 | 1.396 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.297566e-02 | 1.367 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.297566e-02 | 1.367 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 3.957921e-02 | 1.403 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.779860e-02 | 1.423 |
| R-HSA-162592 | Integration of provirus | 3.957921e-02 | 1.403 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.297566e-02 | 1.367 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.017749e-02 | 1.396 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.590186e-02 | 1.445 |
| R-HSA-163685 | Integration of energy metabolism | 4.278643e-02 | 1.369 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.304424e-02 | 1.366 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.278643e-02 | 1.369 |
| R-HSA-1280218 | Adaptive Immune System | 3.904083e-02 | 1.408 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.975186e-02 | 1.401 |
| R-HSA-162906 | HIV Infection | 3.593412e-02 | 1.444 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 3.957921e-02 | 1.403 |
| R-HSA-420092 | Glucagon-type ligand receptors | 3.747528e-02 | 1.426 |
| R-HSA-8939211 | ESR-mediated signaling | 4.483008e-02 | 1.348 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.529564e-02 | 1.344 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 4.586885e-02 | 1.338 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.586885e-02 | 1.338 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.586885e-02 | 1.338 |
| R-HSA-5357801 | Programmed Cell Death | 4.799781e-02 | 1.319 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.813032e-02 | 1.318 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.813032e-02 | 1.318 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.821465e-02 | 1.317 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.821465e-02 | 1.317 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.885601e-02 | 1.311 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.885601e-02 | 1.311 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.885601e-02 | 1.311 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 6.050854e-02 | 1.218 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 6.050854e-02 | 1.218 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 4.949221e-02 | 1.305 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 6.019254e-02 | 1.220 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.193605e-02 | 1.285 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.836993e-02 | 1.234 |
| R-HSA-191859 | snRNP Assembly | 5.265783e-02 | 1.279 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.265783e-02 | 1.279 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 6.516019e-02 | 1.186 |
| R-HSA-977443 | GABA receptor activation | 5.500565e-02 | 1.260 |
| R-HSA-392518 | Signal amplification | 5.510777e-02 | 1.259 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 6.019254e-02 | 1.220 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 6.019254e-02 | 1.220 |
| R-HSA-1502540 | Signaling by Activin | 6.019254e-02 | 1.220 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.193605e-02 | 1.285 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.372322e-02 | 1.196 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.740925e-02 | 1.241 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.500565e-02 | 1.260 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.802160e-02 | 1.236 |
| R-HSA-5205647 | Mitophagy | 5.510777e-02 | 1.259 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.510777e-02 | 1.259 |
| R-HSA-4641258 | Degradation of DVL | 6.516019e-02 | 1.186 |
| R-HSA-8953854 | Metabolism of RNA | 5.701178e-02 | 1.244 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.565586e-02 | 1.254 |
| R-HSA-68875 | Mitotic Prophase | 6.324257e-02 | 1.199 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 6.172119e-02 | 1.210 |
| R-HSA-4641257 | Degradation of AXIN | 6.516019e-02 | 1.186 |
| R-HSA-8876725 | Protein methylation | 6.019254e-02 | 1.220 |
| R-HSA-112043 | PLC beta mediated events | 5.740925e-02 | 1.241 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.193605e-02 | 1.285 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.510777e-02 | 1.259 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.510777e-02 | 1.259 |
| R-HSA-169911 | Regulation of Apoptosis | 5.836993e-02 | 1.234 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.986836e-02 | 1.223 |
| R-HSA-9663891 | Selective autophagy | 5.373682e-02 | 1.270 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.500565e-02 | 1.260 |
| R-HSA-168255 | Influenza Infection | 5.738876e-02 | 1.241 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 5.836993e-02 | 1.234 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.836993e-02 | 1.234 |
| R-HSA-74160 | Gene expression (Transcription) | 5.011761e-02 | 1.300 |
| R-HSA-9824446 | Viral Infection Pathways | 5.750657e-02 | 1.240 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.238271e-02 | 1.205 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.961138e-02 | 1.225 |
| R-HSA-176412 | Phosphorylation of the APC/C | 6.581268e-02 | 1.182 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 6.581268e-02 | 1.182 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.711331e-02 | 1.173 |
| R-HSA-69275 | G2/M Transition | 6.722623e-02 | 1.172 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 6.868547e-02 | 1.163 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.868547e-02 | 1.163 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 6.868547e-02 | 1.163 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.021672e-02 | 1.154 |
| R-HSA-195721 | Signaling by WNT | 7.148675e-02 | 1.146 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 7.159998e-02 | 1.145 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 7.159998e-02 | 1.145 |
| R-HSA-69541 | Stabilization of p53 | 7.229556e-02 | 1.141 |
| R-HSA-112040 | G-protein mediated events | 7.298571e-02 | 1.137 |
| R-HSA-69206 | G1/S Transition | 7.448935e-02 | 1.128 |
| R-HSA-168249 | Innate Immune System | 7.560022e-02 | 1.121 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 7.598892e-02 | 1.119 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 7.598892e-02 | 1.119 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 7.598892e-02 | 1.119 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 7.598892e-02 | 1.119 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 9.880538e-02 | 1.005 |
| R-HSA-4719360 | Defective DPM3 causes DPM3-CDG | 9.880538e-02 | 1.005 |
| R-HSA-4719377 | Defective DPM2 causes DPM2-CDG | 9.880538e-02 | 1.005 |
| R-HSA-4717374 | Defective DPM1 causes DPM1-CDG | 9.880538e-02 | 1.005 |
| R-HSA-164378 | PKA activation in glucagon signalling | 8.363951e-02 | 1.078 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 8.987420e-02 | 1.046 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.027318e-01 | 0.988 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.048439e-01 | 0.979 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.075944e-01 | 0.968 |
| R-HSA-6798695 | Neutrophil degranulation | 7.747625e-02 | 1.111 |
| R-HSA-163615 | PKA activation | 8.363951e-02 | 1.078 |
| R-HSA-9843745 | Adipogenesis | 8.895782e-02 | 1.051 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.444216e-02 | 1.073 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 7.754523e-02 | 1.110 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.075944e-01 | 0.968 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 8.743607e-02 | 1.058 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 9.880538e-02 | 1.005 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.984670e-02 | 1.046 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 9.624099e-02 | 1.017 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.976397e-02 | 1.098 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 8.363951e-02 | 1.078 |
| R-HSA-165159 | MTOR signalling | 8.755263e-02 | 1.058 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 7.985558e-02 | 1.098 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 9.880538e-02 | 1.005 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 8.363951e-02 | 1.078 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 9.980678e-02 | 1.001 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.075944e-01 | 0.968 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.131673e-01 | 0.946 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.027318e-01 | 0.988 |
| R-HSA-1181150 | Signaling by NODAL | 9.624099e-02 | 1.017 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.064466e-01 | 0.973 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.160548e-01 | 0.935 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.070045e-01 | 0.971 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 1.093389e-01 | 0.961 |
| R-HSA-4086398 | Ca2+ pathway | 9.048083e-02 | 1.043 |
| R-HSA-5652084 | Fructose metabolism | 1.160548e-01 | 0.935 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.093389e-01 | 0.961 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.027318e-01 | 0.988 |
| R-HSA-110320 | Translesion Synthesis by POLH | 8.987420e-02 | 1.046 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.045639e-01 | 0.981 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 7.976397e-02 | 1.098 |
| R-HSA-3214858 | RMTs methylate histone arginines | 9.564820e-02 | 1.019 |
| R-HSA-8852135 | Protein ubiquitination | 9.672060e-02 | 1.014 |
| R-HSA-8854214 | TBC/RABGAPs | 9.156291e-02 | 1.038 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 9.624099e-02 | 1.017 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.040369e-01 | 0.983 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.075944e-01 | 0.968 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.103799e-01 | 0.957 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.741290e-02 | 1.111 |
| R-HSA-5619084 | ABC transporter disorders | 1.064466e-01 | 0.973 |
| R-HSA-70171 | Glycolysis | 8.414047e-02 | 1.075 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 1.083367e-01 | 0.965 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 1.160548e-01 | 0.935 |
| R-HSA-9909396 | Circadian clock | 9.114178e-02 | 1.040 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.040369e-01 | 0.983 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 9.980678e-02 | 1.001 |
| R-HSA-913531 | Interferon Signaling | 8.261966e-02 | 1.083 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.659942e-02 | 1.062 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 8.363951e-02 | 1.078 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 7.976397e-02 | 1.098 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.719872e-02 | 1.012 |
| R-HSA-9679506 | SARS-CoV Infections | 9.641478e-02 | 1.016 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.048485e-01 | 0.979 |
| R-HSA-109581 | Apoptosis | 8.464821e-02 | 1.072 |
| R-HSA-157118 | Signaling by NOTCH | 9.635729e-02 | 1.016 |
| R-HSA-202403 | TCR signaling | 1.132003e-01 | 0.946 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.096435e-01 | 0.960 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.171384e-01 | 0.931 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.171384e-01 | 0.931 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 1.173661e-01 | 0.930 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1.173661e-01 | 0.930 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 1.173661e-01 | 0.930 |
| R-HSA-888568 | GABA synthesis | 1.173661e-01 | 0.930 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.195644e-01 | 0.922 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.200709e-01 | 0.921 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.216366e-01 | 0.915 |
| R-HSA-597592 | Post-translational protein modification | 1.223062e-01 | 0.913 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.228723e-01 | 0.911 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.228723e-01 | 0.911 |
| R-HSA-5688426 | Deubiquitination | 1.234949e-01 | 0.908 |
| R-HSA-2559583 | Cellular Senescence | 1.244647e-01 | 0.905 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.261972e-01 | 0.899 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.533518e-01 | 0.814 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 1.533518e-01 | 0.814 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.533518e-01 | 0.814 |
| R-HSA-111957 | Cam-PDE 1 activation | 1.533518e-01 | 0.814 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.707922e-01 | 0.768 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.707922e-01 | 0.768 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.707922e-01 | 0.768 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 1.707922e-01 | 0.768 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.878745e-01 | 0.726 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.878745e-01 | 0.726 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 1.878745e-01 | 0.726 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 1.878745e-01 | 0.726 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.527659e-01 | 0.597 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.527659e-01 | 0.597 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.527659e-01 | 0.597 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.527659e-01 | 0.597 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.297842e-01 | 0.887 |
| R-HSA-8949613 | Cristae formation | 1.510210e-01 | 0.821 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.655339e-01 | 0.781 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.655339e-01 | 0.781 |
| R-HSA-72649 | Translation initiation complex formation | 1.402356e-01 | 0.853 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.498731e-01 | 0.824 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.254736e-01 | 0.647 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.597161e-01 | 0.797 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.697501e-01 | 0.770 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.811482e-01 | 0.742 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.033423e-01 | 0.692 |
| R-HSA-72172 | mRNA Splicing | 1.887092e-01 | 0.724 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.589205e-01 | 0.799 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.802768e-01 | 0.744 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.852669e-01 | 0.732 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.370446e-01 | 0.625 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.061633e-01 | 0.686 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.498731e-01 | 0.824 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.369722e-01 | 0.863 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.369722e-01 | 0.863 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.386361e-01 | 0.622 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.877210e-01 | 0.726 |
| R-HSA-525793 | Myogenesis | 1.438650e-01 | 0.842 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.355456e-01 | 0.868 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.707922e-01 | 0.768 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 2.046059e-01 | 0.689 |
| R-HSA-9609646 | HCMV Infection | 2.036827e-01 | 0.691 |
| R-HSA-72766 | Translation | 1.490449e-01 | 0.827 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.533518e-01 | 0.814 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 1.533518e-01 | 0.814 |
| R-HSA-162699 | Synthesis of dolichyl-phosphate mannose | 1.533518e-01 | 0.814 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 1.878745e-01 | 0.726 |
| R-HSA-5652227 | Fructose biosynthesis | 2.046059e-01 | 0.689 |
| R-HSA-176974 | Unwinding of DNA | 2.209936e-01 | 0.656 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 2.370446e-01 | 0.625 |
| R-HSA-4839744 | Signaling by APC mutants | 2.527659e-01 | 0.597 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.877210e-01 | 0.726 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.027297e-01 | 0.693 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.314995e-01 | 0.881 |
| R-HSA-9610379 | HCMV Late Events | 1.604765e-01 | 0.795 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.878745e-01 | 0.726 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.952069e-01 | 0.710 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.582459e-01 | 0.801 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.354986e-01 | 0.868 |
| R-HSA-9758941 | Gastrulation | 1.379526e-01 | 0.860 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.728793e-01 | 0.762 |
| R-HSA-2161517 | Abacavir transmembrane transport | 1.707922e-01 | 0.768 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.707922e-01 | 0.768 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 1.878745e-01 | 0.726 |
| R-HSA-446107 | Type I hemidesmosome assembly | 2.046059e-01 | 0.689 |
| R-HSA-9734207 | Nucleotide salvage defects | 2.046059e-01 | 0.689 |
| R-HSA-164843 | 2-LTR circle formation | 2.370446e-01 | 0.625 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.728793e-01 | 0.762 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.748340e-01 | 0.757 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.367840e-01 | 0.864 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.528611e-01 | 0.816 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.209936e-01 | 0.656 |
| R-HSA-71336 | Pentose phosphate pathway | 2.483913e-01 | 0.605 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.130313e-01 | 0.672 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.130313e-01 | 0.672 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.510210e-01 | 0.821 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.728793e-01 | 0.762 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.547016e-01 | 0.811 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.299155e-01 | 0.886 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.952069e-01 | 0.710 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.633987e-01 | 0.787 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 1.355456e-01 | 0.868 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 1.355456e-01 | 0.868 |
| R-HSA-201688 | WNT mediated activation of DVL | 2.209936e-01 | 0.656 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.370446e-01 | 0.625 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.510210e-01 | 0.821 |
| R-HSA-69481 | G2/M Checkpoints | 1.763165e-01 | 0.754 |
| R-HSA-422356 | Regulation of insulin secretion | 1.935944e-01 | 0.713 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.438650e-01 | 0.842 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 2.330989e-01 | 0.632 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 1.271515e-01 | 0.896 |
| R-HSA-392499 | Metabolism of proteins | 1.448447e-01 | 0.839 |
| R-HSA-1268020 | Mitochondrial protein import | 1.799603e-01 | 0.745 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.533518e-01 | 0.814 |
| R-HSA-8964011 | HDL clearance | 1.707922e-01 | 0.768 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.046059e-01 | 0.689 |
| R-HSA-448706 | Interleukin-1 processing | 2.209936e-01 | 0.656 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 2.527659e-01 | 0.597 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.438650e-01 | 0.842 |
| R-HSA-2161522 | Abacavir ADME | 1.438650e-01 | 0.842 |
| R-HSA-73614 | Pyrimidine salvage | 1.582459e-01 | 0.801 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.877210e-01 | 0.726 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.331601e-01 | 0.632 |
| R-HSA-3214847 | HATs acetylate histones | 1.978016e-01 | 0.704 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.510210e-01 | 0.821 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.502045e-01 | 0.602 |
| R-HSA-8956321 | Nucleotide salvage | 1.748340e-01 | 0.757 |
| R-HSA-4839726 | Chromatin organization | 2.010333e-01 | 0.697 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 2.061633e-01 | 0.686 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.502045e-01 | 0.602 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.279803e-01 | 0.642 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.400890e-01 | 0.854 |
| R-HSA-162582 | Signal Transduction | 1.309098e-01 | 0.883 |
| R-HSA-5689877 | Josephin domain DUBs | 2.370446e-01 | 0.625 |
| R-HSA-74217 | Purine salvage | 2.407394e-01 | 0.618 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.370446e-01 | 0.625 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.630936e-01 | 0.788 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.462170e-01 | 0.835 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.020365e-01 | 0.695 |
| R-HSA-9833110 | RSV-host interactions | 2.235970e-01 | 0.651 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.370446e-01 | 0.625 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.370446e-01 | 0.625 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.799603e-01 | 0.745 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.344033e-01 | 0.872 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.406825e-01 | 0.852 |
| R-HSA-75893 | TNF signaling | 1.498731e-01 | 0.824 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.981909e-01 | 0.703 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.513695e-01 | 0.820 |
| R-HSA-212436 | Generic Transcription Pathway | 1.443651e-01 | 0.841 |
| R-HSA-418346 | Platelet homeostasis | 2.323852e-01 | 0.634 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.062983e-01 | 0.686 |
| R-HSA-70326 | Glucose metabolism | 1.400890e-01 | 0.854 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.323852e-01 | 0.634 |
| R-HSA-373755 | Semaphorin interactions | 1.851270e-01 | 0.733 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.155665e-01 | 0.666 |
| R-HSA-162587 | HIV Life Cycle | 1.604765e-01 | 0.795 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.978016e-01 | 0.704 |
| R-HSA-3371556 | Cellular response to heat stress | 1.528611e-01 | 0.816 |
| R-HSA-5663205 | Infectious disease | 2.417234e-01 | 0.617 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.046059e-01 | 0.689 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.373723e-01 | 0.625 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.649944e-01 | 0.783 |
| R-HSA-202424 | Downstream TCR signaling | 1.532399e-01 | 0.815 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.693110e-01 | 0.771 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.438650e-01 | 0.842 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.802768e-01 | 0.744 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.254736e-01 | 0.647 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.156623e-01 | 0.666 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.130313e-01 | 0.672 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.508972e-01 | 0.821 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.483913e-01 | 0.605 |
| R-HSA-351202 | Metabolism of polyamines | 1.697501e-01 | 0.770 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.496521e-01 | 0.603 |
| R-HSA-1483255 | PI Metabolism | 2.105861e-01 | 0.677 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.483913e-01 | 0.605 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.277074e-01 | 0.643 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.195785e-01 | 0.658 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.307564e-01 | 0.884 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 2.527659e-01 | 0.597 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.254736e-01 | 0.647 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.331601e-01 | 0.632 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 2.441340e-01 | 0.612 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.541965e-01 | 0.595 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.560509e-01 | 0.592 |
| R-HSA-9646399 | Aggrephagy | 2.560509e-01 | 0.592 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.560509e-01 | 0.592 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.592221e-01 | 0.586 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.636403e-01 | 0.579 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.637146e-01 | 0.579 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.637146e-01 | 0.579 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.652512e-01 | 0.576 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.663120e-01 | 0.575 |
| R-HSA-4086400 | PCP/CE pathway | 2.663120e-01 | 0.575 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 2.681642e-01 | 0.572 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.681642e-01 | 0.572 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.681642e-01 | 0.572 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.681642e-01 | 0.572 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.681642e-01 | 0.572 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.681642e-01 | 0.572 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.713790e-01 | 0.566 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.713790e-01 | 0.566 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.713790e-01 | 0.566 |
| R-HSA-9675108 | Nervous system development | 2.765608e-01 | 0.558 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.790409e-01 | 0.554 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.791888e-01 | 0.554 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.820272e-01 | 0.550 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.830989e-01 | 0.548 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.832461e-01 | 0.548 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.832461e-01 | 0.548 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.832461e-01 | 0.548 |
| R-HSA-9842663 | Signaling by LTK | 2.832461e-01 | 0.548 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.832461e-01 | 0.548 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.832461e-01 | 0.548 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 2.832461e-01 | 0.548 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.832461e-01 | 0.548 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.832461e-01 | 0.548 |
| R-HSA-9710421 | Defective pyroptosis | 2.866971e-01 | 0.543 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.866971e-01 | 0.543 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.866971e-01 | 0.543 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.875079e-01 | 0.541 |
| R-HSA-9609690 | HCMV Early Events | 2.918167e-01 | 0.535 |
| R-HSA-422475 | Axon guidance | 2.926358e-01 | 0.534 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.943445e-01 | 0.531 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.980181e-01 | 0.526 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.980181e-01 | 0.526 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.980181e-01 | 0.526 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.980181e-01 | 0.526 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.980181e-01 | 0.526 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2.980181e-01 | 0.526 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 2.980181e-01 | 0.526 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.999739e-01 | 0.523 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.019805e-01 | 0.520 |
| R-HSA-1500620 | Meiosis | 3.056120e-01 | 0.515 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.096020e-01 | 0.509 |
| R-HSA-73886 | Chromosome Maintenance | 3.097692e-01 | 0.509 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 3.124865e-01 | 0.505 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 3.124865e-01 | 0.505 |
| R-HSA-1170546 | Prolactin receptor signaling | 3.124865e-01 | 0.505 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 3.124865e-01 | 0.505 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.124865e-01 | 0.505 |
| R-HSA-9793528 | Ciprofloxacin ADME | 3.124865e-01 | 0.505 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.142755e-01 | 0.503 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.169542e-01 | 0.499 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.190803e-01 | 0.496 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.190803e-01 | 0.496 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.219618e-01 | 0.492 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.247918e-01 | 0.488 |
| R-HSA-9027284 | Erythropoietin activates RAS | 3.266576e-01 | 0.486 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 3.266576e-01 | 0.486 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.266576e-01 | 0.486 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 3.266576e-01 | 0.486 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.266576e-01 | 0.486 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 3.266576e-01 | 0.486 |
| R-HSA-171007 | p38MAPK events | 3.266576e-01 | 0.486 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.266576e-01 | 0.486 |
| R-HSA-193639 | p75NTR signals via NF-kB | 3.266576e-01 | 0.486 |
| R-HSA-156902 | Peptide chain elongation | 3.281950e-01 | 0.484 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.323550e-01 | 0.478 |
| R-HSA-73893 | DNA Damage Bypass | 3.323550e-01 | 0.478 |
| R-HSA-194138 | Signaling by VEGF | 3.330860e-01 | 0.477 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 3.394873e-01 | 0.469 |
| R-HSA-109704 | PI3K Cascade | 3.398939e-01 | 0.469 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 3.405375e-01 | 0.468 |
| R-HSA-9708530 | Regulation of BACH1 activity | 3.405375e-01 | 0.468 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 3.405375e-01 | 0.468 |
| R-HSA-70350 | Fructose catabolism | 3.405375e-01 | 0.468 |
| R-HSA-71262 | Carnitine synthesis | 3.405375e-01 | 0.468 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 3.405375e-01 | 0.468 |
| R-HSA-9678110 | Attachment and Entry | 3.405375e-01 | 0.468 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.451295e-01 | 0.462 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.507674e-01 | 0.455 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.533903e-01 | 0.452 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.541321e-01 | 0.451 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.541321e-01 | 0.451 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.541321e-01 | 0.451 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.541321e-01 | 0.451 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.541321e-01 | 0.451 |
| R-HSA-70370 | Galactose catabolism | 3.541321e-01 | 0.451 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.548905e-01 | 0.450 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.548905e-01 | 0.450 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.548905e-01 | 0.450 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.564000e-01 | 0.448 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.564842e-01 | 0.448 |
| R-HSA-72306 | tRNA processing | 3.577754e-01 | 0.446 |
| R-HSA-418555 | G alpha (s) signalling events | 3.618618e-01 | 0.441 |
| R-HSA-1221632 | Meiotic synapsis | 3.623439e-01 | 0.441 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.623439e-01 | 0.441 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.674472e-01 | 0.435 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 3.674472e-01 | 0.435 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.697650e-01 | 0.432 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.705257e-01 | 0.431 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.732551e-01 | 0.428 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.732551e-01 | 0.428 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.754543e-01 | 0.425 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.771517e-01 | 0.423 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.771517e-01 | 0.423 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.788557e-01 | 0.422 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.804887e-01 | 0.420 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.804887e-01 | 0.420 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.804887e-01 | 0.420 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.804887e-01 | 0.420 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.804887e-01 | 0.420 |
| R-HSA-3928664 | Ephrin signaling | 3.804887e-01 | 0.420 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.804887e-01 | 0.420 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.844457e-01 | 0.415 |
| R-HSA-1296071 | Potassium Channels | 3.844457e-01 | 0.415 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.900243e-01 | 0.409 |
| R-HSA-112399 | IRS-mediated signalling | 3.918155e-01 | 0.407 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.932620e-01 | 0.405 |
| R-HSA-9834899 | Specification of the neural plate border | 3.932620e-01 | 0.405 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.932620e-01 | 0.405 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.932620e-01 | 0.405 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.955903e-01 | 0.403 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.955903e-01 | 0.403 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.955903e-01 | 0.403 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.990893e-01 | 0.399 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.990893e-01 | 0.399 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 4.011430e-01 | 0.397 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.057728e-01 | 0.392 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 4.057728e-01 | 0.392 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 4.057728e-01 | 0.392 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.057728e-01 | 0.392 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.057728e-01 | 0.392 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.057728e-01 | 0.392 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.057728e-01 | 0.392 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 4.057728e-01 | 0.392 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 4.057728e-01 | 0.392 |
| R-HSA-196108 | Pregnenolone biosynthesis | 4.057728e-01 | 0.392 |
| R-HSA-445144 | Signal transduction by L1 | 4.057728e-01 | 0.392 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.063225e-01 | 0.391 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.063225e-01 | 0.391 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.122046e-01 | 0.385 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.135135e-01 | 0.384 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.135135e-01 | 0.384 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.135135e-01 | 0.384 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.135135e-01 | 0.384 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.135135e-01 | 0.384 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.135135e-01 | 0.384 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.177118e-01 | 0.379 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.177118e-01 | 0.379 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.177118e-01 | 0.379 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 4.180264e-01 | 0.379 |
| R-HSA-2161541 | Abacavir metabolism | 4.180264e-01 | 0.379 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 4.180264e-01 | 0.379 |
| R-HSA-167044 | Signalling to RAS | 4.180264e-01 | 0.379 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 4.180264e-01 | 0.379 |
| R-HSA-199991 | Membrane Trafficking | 4.206265e-01 | 0.376 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.206611e-01 | 0.376 |
| R-HSA-450294 | MAP kinase activation | 4.206611e-01 | 0.376 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.216990e-01 | 0.375 |
| R-HSA-192823 | Viral mRNA Translation | 4.232021e-01 | 0.373 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.263260e-01 | 0.370 |
| R-HSA-72312 | rRNA processing | 4.268406e-01 | 0.370 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.277639e-01 | 0.369 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.286748e-01 | 0.368 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 4.300280e-01 | 0.367 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.300280e-01 | 0.367 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.300280e-01 | 0.367 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 4.300280e-01 | 0.367 |
| R-HSA-9755088 | Ribavirin ADME | 4.300280e-01 | 0.367 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.300280e-01 | 0.367 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.300280e-01 | 0.367 |
| R-HSA-9694614 | Attachment and Entry | 4.300280e-01 | 0.367 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.348209e-01 | 0.362 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.355223e-01 | 0.361 |
| R-HSA-9658195 | Leishmania infection | 4.360743e-01 | 0.360 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.360743e-01 | 0.360 |
| R-HSA-15869 | Metabolism of nucleotides | 4.414482e-01 | 0.355 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.417828e-01 | 0.355 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.417828e-01 | 0.355 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 4.417828e-01 | 0.355 |
| R-HSA-71384 | Ethanol oxidation | 4.417828e-01 | 0.355 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.417828e-01 | 0.355 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.418308e-01 | 0.355 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.418308e-01 | 0.355 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.418308e-01 | 0.355 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.432806e-01 | 0.353 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.487927e-01 | 0.348 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.487927e-01 | 0.348 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.492383e-01 | 0.348 |
| R-HSA-211000 | Gene Silencing by RNA | 4.503738e-01 | 0.346 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.532959e-01 | 0.344 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.532959e-01 | 0.344 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.532959e-01 | 0.344 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.557055e-01 | 0.341 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.557470e-01 | 0.341 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.610981e-01 | 0.336 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.628483e-01 | 0.335 |
| R-HSA-429947 | Deadenylation of mRNA | 4.645723e-01 | 0.333 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.645723e-01 | 0.333 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.645723e-01 | 0.333 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.645723e-01 | 0.333 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 4.664266e-01 | 0.331 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.693801e-01 | 0.328 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.693801e-01 | 0.328 |
| R-HSA-5218859 | Regulated Necrosis | 4.693801e-01 | 0.328 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.756167e-01 | 0.323 |
| R-HSA-420029 | Tight junction interactions | 4.756167e-01 | 0.323 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.756167e-01 | 0.323 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.756167e-01 | 0.323 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.756167e-01 | 0.323 |
| R-HSA-9839394 | TGFBR3 expression | 4.756167e-01 | 0.323 |
| R-HSA-9830364 | Formation of the nephric duct | 4.756167e-01 | 0.323 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.761403e-01 | 0.322 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.770131e-01 | 0.321 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.770131e-01 | 0.321 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.808088e-01 | 0.318 |
| R-HSA-73887 | Death Receptor Signaling | 4.808088e-01 | 0.318 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.822699e-01 | 0.317 |
| R-HSA-1483257 | Phospholipid metabolism | 4.826813e-01 | 0.316 |
| R-HSA-448424 | Interleukin-17 signaling | 4.828480e-01 | 0.316 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.828480e-01 | 0.316 |
| R-HSA-1989781 | PPARA activates gene expression | 4.852627e-01 | 0.314 |
| R-HSA-3295583 | TRP channels | 4.864340e-01 | 0.313 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 4.864340e-01 | 0.313 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.864340e-01 | 0.313 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.895025e-01 | 0.310 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.895025e-01 | 0.310 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.910140e-01 | 0.309 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.941244e-01 | 0.306 |
| R-HSA-74259 | Purine catabolism | 4.961032e-01 | 0.304 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.970288e-01 | 0.304 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.970288e-01 | 0.304 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.970288e-01 | 0.304 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 4.970288e-01 | 0.304 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.978877e-01 | 0.303 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.978877e-01 | 0.303 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.026495e-01 | 0.299 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.030411e-01 | 0.298 |
| R-HSA-5620971 | Pyroptosis | 5.074057e-01 | 0.295 |
| R-HSA-622312 | Inflammasomes | 5.074057e-01 | 0.295 |
| R-HSA-373760 | L1CAM interactions | 5.081673e-01 | 0.294 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.091407e-01 | 0.293 |
| R-HSA-380287 | Centrosome maturation | 5.155765e-01 | 0.288 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 5.175691e-01 | 0.286 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 5.175691e-01 | 0.286 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 5.175691e-01 | 0.286 |
| R-HSA-180024 | DARPP-32 events | 5.175691e-01 | 0.286 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 5.175691e-01 | 0.286 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.183364e-01 | 0.285 |
| R-HSA-1266738 | Developmental Biology | 5.209848e-01 | 0.283 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.219562e-01 | 0.282 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.219562e-01 | 0.282 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.233785e-01 | 0.281 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.233785e-01 | 0.281 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.246153e-01 | 0.280 |
| R-HSA-68962 | Activation of the pre-replicative complex | 5.275235e-01 | 0.278 |
| R-HSA-2424491 | DAP12 signaling | 5.275235e-01 | 0.278 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 5.275235e-01 | 0.278 |
| R-HSA-112311 | Neurotransmitter clearance | 5.275235e-01 | 0.278 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.275235e-01 | 0.278 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.334202e-01 | 0.273 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.345461e-01 | 0.272 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.372730e-01 | 0.270 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.372730e-01 | 0.270 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 5.372730e-01 | 0.270 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.383295e-01 | 0.269 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.383295e-01 | 0.269 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.432536e-01 | 0.265 |
| R-HSA-1538133 | G0 and Early G1 | 5.468219e-01 | 0.262 |
| R-HSA-69190 | DNA strand elongation | 5.468219e-01 | 0.262 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.561744e-01 | 0.255 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.561744e-01 | 0.255 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.561744e-01 | 0.255 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.561744e-01 | 0.255 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.561744e-01 | 0.255 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.561744e-01 | 0.255 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 5.561744e-01 | 0.255 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.561744e-01 | 0.255 |
| R-HSA-9733709 | Cardiogenesis | 5.561744e-01 | 0.255 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.561744e-01 | 0.255 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.561744e-01 | 0.255 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.590378e-01 | 0.253 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.601599e-01 | 0.252 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.626424e-01 | 0.250 |
| R-HSA-390522 | Striated Muscle Contraction | 5.653344e-01 | 0.248 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.653344e-01 | 0.248 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.653344e-01 | 0.248 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.653344e-01 | 0.248 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 5.653344e-01 | 0.248 |
| R-HSA-189483 | Heme degradation | 5.653344e-01 | 0.248 |
| R-HSA-112316 | Neuronal System | 5.657389e-01 | 0.247 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.709355e-01 | 0.243 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.721481e-01 | 0.242 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.743059e-01 | 0.241 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.743059e-01 | 0.241 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.743059e-01 | 0.241 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.743059e-01 | 0.241 |
| R-HSA-5673000 | RAF activation | 5.743059e-01 | 0.241 |
| R-HSA-5365859 | RA biosynthesis pathway | 5.743059e-01 | 0.241 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 5.743059e-01 | 0.241 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.743059e-01 | 0.241 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.744282e-01 | 0.241 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.767967e-01 | 0.239 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.767967e-01 | 0.239 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.830928e-01 | 0.234 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.830928e-01 | 0.234 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.830928e-01 | 0.234 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.830928e-01 | 0.234 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 5.830928e-01 | 0.234 |
| R-HSA-187687 | Signalling to ERKs | 5.830928e-01 | 0.234 |
| R-HSA-1474165 | Reproduction | 5.861648e-01 | 0.232 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.883432e-01 | 0.230 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.883432e-01 | 0.230 |
| R-HSA-3371511 | HSF1 activation | 5.916989e-01 | 0.228 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.916989e-01 | 0.228 |
| R-HSA-69205 | G1/S-Specific Transcription | 5.916989e-01 | 0.228 |
| R-HSA-8853659 | RET signaling | 5.916989e-01 | 0.228 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.916989e-01 | 0.228 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.916989e-01 | 0.228 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.940285e-01 | 0.226 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.996550e-01 | 0.222 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.996550e-01 | 0.222 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 6.001278e-01 | 0.222 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 6.001278e-01 | 0.222 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 6.001278e-01 | 0.222 |
| R-HSA-382551 | Transport of small molecules | 6.078631e-01 | 0.216 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 6.083832e-01 | 0.216 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 6.083832e-01 | 0.216 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 6.164687e-01 | 0.210 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 6.164687e-01 | 0.210 |
| R-HSA-9648002 | RAS processing | 6.164687e-01 | 0.210 |
| R-HSA-201556 | Signaling by ALK | 6.164687e-01 | 0.210 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 6.164687e-01 | 0.210 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 6.164687e-01 | 0.210 |
| R-HSA-5260271 | Diseases of Immune System | 6.243877e-01 | 0.205 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.243877e-01 | 0.205 |
| R-HSA-202433 | Generation of second messenger molecules | 6.243877e-01 | 0.205 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.269071e-01 | 0.203 |
| R-HSA-983712 | Ion channel transport | 6.292456e-01 | 0.201 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 6.321437e-01 | 0.199 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 6.321437e-01 | 0.199 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.373987e-01 | 0.196 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 6.397400e-01 | 0.194 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 6.397400e-01 | 0.194 |
| R-HSA-189451 | Heme biosynthesis | 6.397400e-01 | 0.194 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.403318e-01 | 0.194 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 6.471799e-01 | 0.189 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 6.471799e-01 | 0.189 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.517282e-01 | 0.186 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.527008e-01 | 0.185 |
| R-HSA-1643685 | Disease | 6.547369e-01 | 0.184 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.593789e-01 | 0.181 |
| R-HSA-2172127 | DAP12 interactions | 6.616033e-01 | 0.179 |
| R-HSA-69236 | G1 Phase | 6.616033e-01 | 0.179 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.616033e-01 | 0.179 |
| R-HSA-5683826 | Surfactant metabolism | 6.616033e-01 | 0.179 |
| R-HSA-418594 | G alpha (i) signalling events | 6.678044e-01 | 0.175 |
| R-HSA-166520 | Signaling by NTRKs | 6.718670e-01 | 0.173 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.754387e-01 | 0.170 |
| R-HSA-9675135 | Diseases of DNA repair | 6.754387e-01 | 0.170 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.754387e-01 | 0.170 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.754387e-01 | 0.170 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.754387e-01 | 0.170 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.754387e-01 | 0.170 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.754387e-01 | 0.170 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.757026e-01 | 0.170 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.817586e-01 | 0.166 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.821435e-01 | 0.166 |
| R-HSA-437239 | Recycling pathway of L1 | 6.821435e-01 | 0.166 |
| R-HSA-1483191 | Synthesis of PC | 6.821435e-01 | 0.166 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.887101e-01 | 0.162 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.887101e-01 | 0.162 |
| R-HSA-70263 | Gluconeogenesis | 6.887101e-01 | 0.162 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.911407e-01 | 0.160 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.951415e-01 | 0.158 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.955283e-01 | 0.158 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.955283e-01 | 0.158 |
| R-HSA-9748787 | Azathioprine ADME | 7.014404e-01 | 0.154 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 7.014404e-01 | 0.154 |
| R-HSA-416476 | G alpha (q) signalling events | 7.048124e-01 | 0.152 |
| R-HSA-912446 | Meiotic recombination | 7.076095e-01 | 0.150 |
| R-HSA-3371571 | HSF1-dependent transactivation | 7.076095e-01 | 0.150 |
| R-HSA-9864848 | Complex IV assembly | 7.076095e-01 | 0.150 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 7.076095e-01 | 0.150 |
| R-HSA-2514856 | The phototransduction cascade | 7.076095e-01 | 0.150 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.088029e-01 | 0.149 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.088029e-01 | 0.149 |
| R-HSA-397014 | Muscle contraction | 7.117494e-01 | 0.148 |
| R-HSA-877300 | Interferon gamma signaling | 7.131334e-01 | 0.147 |
| R-HSA-72187 | mRNA 3'-end processing | 7.136515e-01 | 0.147 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 7.136515e-01 | 0.147 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.166793e-01 | 0.145 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 7.195691e-01 | 0.143 |
| R-HSA-8956320 | Nucleotide biosynthesis | 7.195691e-01 | 0.143 |
| R-HSA-9753281 | Paracetamol ADME | 7.310409e-01 | 0.136 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.310409e-01 | 0.136 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.339045e-01 | 0.134 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.366001e-01 | 0.133 |
| R-HSA-177929 | Signaling by EGFR | 7.366001e-01 | 0.133 |
| R-HSA-5619102 | SLC transporter disorders | 7.405571e-01 | 0.130 |
| R-HSA-5621480 | Dectin-2 family | 7.420447e-01 | 0.130 |
| R-HSA-1483166 | Synthesis of PA | 7.420447e-01 | 0.130 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.449912e-01 | 0.128 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 7.473771e-01 | 0.126 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 7.525997e-01 | 0.123 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 7.577145e-01 | 0.120 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.577145e-01 | 0.120 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.627239e-01 | 0.118 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.676301e-01 | 0.115 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.676301e-01 | 0.115 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.716500e-01 | 0.113 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.724351e-01 | 0.112 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.724351e-01 | 0.112 |
| R-HSA-8848021 | Signaling by PTK6 | 7.724351e-01 | 0.112 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.724351e-01 | 0.112 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.862638e-01 | 0.104 |
| R-HSA-8978868 | Fatty acid metabolism | 7.879998e-01 | 0.103 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.906846e-01 | 0.102 |
| R-HSA-9830369 | Kidney development | 7.906846e-01 | 0.102 |
| R-HSA-196071 | Metabolism of steroid hormones | 7.906846e-01 | 0.102 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.950142e-01 | 0.100 |
| R-HSA-114608 | Platelet degranulation | 7.952223e-01 | 0.100 |
| R-HSA-8956319 | Nucleotide catabolism | 8.015514e-01 | 0.096 |
| R-HSA-204005 | COPII-mediated vesicle transport | 8.034074e-01 | 0.095 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 8.074746e-01 | 0.093 |
| R-HSA-189445 | Metabolism of porphyrins | 8.074746e-01 | 0.093 |
| R-HSA-5617833 | Cilium Assembly | 8.104546e-01 | 0.091 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 8.114579e-01 | 0.091 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 8.153590e-01 | 0.089 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.166218e-01 | 0.088 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.191797e-01 | 0.087 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.191797e-01 | 0.087 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.229215e-01 | 0.085 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.301751e-01 | 0.081 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.336901e-01 | 0.079 |
| R-HSA-9659379 | Sensory processing of sound | 8.371325e-01 | 0.077 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 8.405038e-01 | 0.075 |
| R-HSA-9833482 | PKR-mediated signaling | 8.405038e-01 | 0.075 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.412149e-01 | 0.075 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.438056e-01 | 0.074 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.502061e-01 | 0.070 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 8.622332e-01 | 0.064 |
| R-HSA-70268 | Pyruvate metabolism | 8.650863e-01 | 0.063 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.693124e-01 | 0.061 |
| R-HSA-9748784 | Drug ADME | 8.730795e-01 | 0.059 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.732972e-01 | 0.059 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.732972e-01 | 0.059 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.759219e-01 | 0.058 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.834751e-01 | 0.054 |
| R-HSA-1474290 | Collagen formation | 8.858896e-01 | 0.053 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.882542e-01 | 0.051 |
| R-HSA-5389840 | Mitochondrial translation elongation | 8.928377e-01 | 0.049 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.972339e-01 | 0.047 |
| R-HSA-5368286 | Mitochondrial translation initiation | 8.972339e-01 | 0.047 |
| R-HSA-73894 | DNA Repair | 8.975980e-01 | 0.047 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.993640e-01 | 0.046 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.000230e-01 | 0.046 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 9.074533e-01 | 0.042 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.093723e-01 | 0.041 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.108316e-01 | 0.041 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 9.112515e-01 | 0.040 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.123221e-01 | 0.040 |
| R-HSA-611105 | Respiratory electron transport | 9.166549e-01 | 0.038 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.172353e-01 | 0.038 |
| R-HSA-2672351 | Stimuli-sensing channels | 9.183879e-01 | 0.037 |
| R-HSA-5419276 | Mitochondrial translation termination | 9.200807e-01 | 0.036 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 9.249520e-01 | 0.034 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.280339e-01 | 0.032 |
| R-HSA-8957322 | Metabolism of steroids | 9.281519e-01 | 0.032 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.295272e-01 | 0.032 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.324217e-01 | 0.030 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.324217e-01 | 0.030 |
| R-HSA-2980736 | Peptide hormone metabolism | 9.351977e-01 | 0.029 |
| R-HSA-5693538 | Homology Directed Repair | 9.365428e-01 | 0.028 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.432001e-01 | 0.025 |
| R-HSA-428157 | Sphingolipid metabolism | 9.437766e-01 | 0.025 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 9.463479e-01 | 0.024 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 9.463479e-01 | 0.024 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 9.463479e-01 | 0.024 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.536795e-01 | 0.021 |
| R-HSA-5368287 | Mitochondrial translation | 9.608429e-01 | 0.017 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.632346e-01 | 0.016 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.667552e-01 | 0.015 |
| R-HSA-2187338 | Visual phototransduction | 9.682638e-01 | 0.014 |
| R-HSA-388396 | GPCR downstream signalling | 9.700067e-01 | 0.013 |
| R-HSA-2142753 | Arachidonate metabolism | 9.714303e-01 | 0.013 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.723407e-01 | 0.012 |
| R-HSA-109582 | Hemostasis | 9.731571e-01 | 0.012 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.742817e-01 | 0.011 |
| R-HSA-556833 | Metabolism of lipids | 9.838256e-01 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 9.841433e-01 | 0.007 |
| R-HSA-3781865 | Diseases of glycosylation | 9.857354e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.884788e-01 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 9.947362e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.971713e-01 | 0.001 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.980841e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.981826e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.997570e-01 | 0.000 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.998509e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999900e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
ERK5 |
0.640 | 0.171 | 1 | 0.887 |
NLK |
0.639 | 0.197 | 1 | 0.875 |
JNK2 |
0.634 | 0.140 | 1 | 0.795 |
PINK1 |
0.634 | 0.234 | 1 | 0.807 |
MOS |
0.633 | -0.019 | 1 | 0.814 |
CDK8 |
0.633 | 0.137 | 1 | 0.815 |
P38D |
0.633 | 0.153 | 1 | 0.760 |
P38B |
0.632 | 0.134 | 1 | 0.824 |
DYRK2 |
0.632 | 0.089 | 1 | 0.839 |
JNK3 |
0.632 | 0.129 | 1 | 0.818 |
ATR |
0.631 | 0.027 | 1 | 0.761 |
CAMKK2 |
0.631 | 0.288 | -2 | 0.271 |
PRKD1 |
0.630 | 0.057 | -3 | 0.103 |
PRPK |
0.630 | -0.010 | -1 | 0.657 |
SBK |
0.630 | 0.017 | -3 | 0.041 |
CAMKK1 |
0.630 | 0.330 | -2 | 0.274 |
CDC7 |
0.630 | 0.032 | 1 | 0.791 |
DSTYK |
0.629 | 0.037 | 2 | 0.843 |
ULK1 |
0.629 | 0.306 | -3 | 0.375 |
PDHK4 |
0.628 | -0.000 | 1 | 0.777 |
CDK19 |
0.628 | 0.129 | 1 | 0.794 |
P38A |
0.627 | 0.121 | 1 | 0.857 |
COT |
0.626 | -0.079 | 2 | 0.833 |
MAPKAPK2 |
0.626 | 0.015 | -3 | 0.054 |
CLK3 |
0.626 | -0.007 | 1 | 0.876 |
ICK |
0.626 | -0.006 | -3 | 0.107 |
CAMK2D |
0.625 | 0.010 | -3 | 0.116 |
MAPKAPK3 |
0.625 | -0.000 | -3 | 0.084 |
HIPK4 |
0.625 | 0.031 | 1 | 0.837 |
BMPR1B |
0.624 | -0.012 | 1 | 0.769 |
PDHK1 |
0.624 | 0.013 | 1 | 0.750 |
CAMK1B |
0.624 | -0.062 | -3 | 0.101 |
CAMK2G |
0.624 | -0.006 | 2 | 0.796 |
ULK2 |
0.624 | 0.216 | 2 | 0.733 |
TGFBR1 |
0.624 | -0.005 | -2 | 0.082 |
GRK1 |
0.624 | -0.025 | -2 | 0.079 |
CDKL1 |
0.624 | -0.044 | -3 | 0.088 |
PIM3 |
0.624 | -0.070 | -3 | 0.068 |
BMPR2 |
0.624 | -0.140 | -2 | 0.110 |
RAF1 |
0.623 | -0.032 | 1 | 0.747 |
NEK9 |
0.623 | 0.191 | 2 | 0.783 |
IKKB |
0.623 | -0.044 | -2 | 0.130 |
MTOR |
0.622 | -0.031 | 1 | 0.769 |
CDKL5 |
0.622 | -0.015 | -3 | 0.088 |
PRKD2 |
0.622 | 0.011 | -3 | 0.077 |
ALK2 |
0.622 | -0.001 | -2 | 0.118 |
ERK1 |
0.622 | 0.120 | 1 | 0.811 |
DYRK4 |
0.621 | 0.095 | 1 | 0.801 |
IKKA |
0.621 | -0.035 | -2 | 0.115 |
CHK1 |
0.621 | -0.024 | -3 | 0.103 |
PRP4 |
0.620 | 0.014 | -3 | 0.072 |
LATS1 |
0.620 | -0.061 | -3 | 0.073 |
ACVR2B |
0.620 | -0.038 | -2 | 0.072 |
KIS |
0.620 | 0.076 | 1 | 0.837 |
P38G |
0.620 | 0.116 | 1 | 0.748 |
CDK1 |
0.620 | 0.098 | 1 | 0.810 |
SRPK1 |
0.620 | -0.008 | -3 | 0.056 |
CDK13 |
0.620 | 0.118 | 1 | 0.812 |
GRK5 |
0.619 | -0.096 | -3 | 0.095 |
DAPK2 |
0.619 | -0.072 | -3 | 0.111 |
GRK6 |
0.619 | -0.014 | 1 | 0.766 |
CK1D |
0.619 | -0.051 | -3 | 0.028 |
PIM1 |
0.619 | -0.060 | -3 | 0.059 |
CAMLCK |
0.618 | -0.073 | -2 | 0.107 |
MASTL |
0.618 | -0.065 | -2 | 0.118 |
CLK2 |
0.618 | 0.019 | -3 | 0.053 |
CLK4 |
0.618 | -0.011 | -3 | 0.074 |
NIK |
0.618 | -0.083 | -3 | 0.107 |
DYRK1B |
0.618 | 0.062 | 1 | 0.814 |
HIPK1 |
0.618 | 0.047 | 1 | 0.844 |
CDK9 |
0.617 | 0.125 | 1 | 0.815 |
ALK4 |
0.617 | -0.051 | -2 | 0.076 |
P90RSK |
0.616 | -0.042 | -3 | 0.084 |
LKB1 |
0.616 | 0.085 | -3 | 0.182 |
PKN3 |
0.616 | -0.020 | -3 | 0.167 |
CAMK2A |
0.616 | -0.004 | 2 | 0.797 |
LATS2 |
0.616 | -0.051 | -5 | 0.500 |
SRPK3 |
0.616 | -0.016 | -3 | 0.069 |
IKKE |
0.616 | 0.029 | 1 | 0.638 |
RSK2 |
0.615 | -0.059 | -3 | 0.056 |
ACVR2A |
0.615 | -0.053 | -2 | 0.066 |
MAK |
0.615 | 0.023 | -2 | 0.072 |
DYRK3 |
0.615 | 0.031 | 1 | 0.833 |
CDK7 |
0.615 | 0.086 | 1 | 0.830 |
DYRK1A |
0.615 | 0.035 | 1 | 0.845 |
JNK1 |
0.615 | 0.112 | 1 | 0.788 |
SMG1 |
0.615 | 0.023 | 1 | 0.712 |
HIPK3 |
0.614 | 0.065 | 1 | 0.828 |
NEK7 |
0.614 | -0.010 | -3 | 0.176 |
MEK1 |
0.614 | -0.033 | 2 | 0.811 |
CAMK2B |
0.614 | -0.006 | 2 | 0.792 |
CHAK2 |
0.614 | -0.021 | -1 | 0.604 |
NDR2 |
0.614 | -0.085 | -3 | 0.068 |
GRK2 |
0.614 | -0.045 | -2 | 0.074 |
HIPK2 |
0.613 | 0.064 | 1 | 0.784 |
MAPKAPK5 |
0.613 | 0.011 | -3 | 0.126 |
HUNK |
0.613 | -0.005 | 2 | 0.793 |
SKMLCK |
0.613 | -0.105 | -2 | 0.081 |
BMPR1A |
0.613 | -0.022 | 1 | 0.740 |
P70S6KB |
0.613 | -0.074 | -3 | 0.078 |
PIM2 |
0.613 | -0.054 | -3 | 0.072 |
DLK |
0.612 | -0.096 | 1 | 0.744 |
CDK12 |
0.612 | 0.106 | 1 | 0.793 |
NUAK2 |
0.612 | -0.055 | -3 | 0.111 |
BRAF |
0.612 | -0.006 | -4 | 0.500 |
NEK6 |
0.612 | -0.029 | -2 | 0.111 |
PRKD3 |
0.612 | -0.026 | -3 | 0.078 |
CLK1 |
0.612 | -0.011 | -3 | 0.071 |
ERK2 |
0.612 | 0.103 | 1 | 0.827 |
GRK7 |
0.612 | -0.059 | 1 | 0.722 |
CDK17 |
0.612 | 0.106 | 1 | 0.750 |
VRK2 |
0.611 | -0.020 | 1 | 0.804 |
CDK18 |
0.611 | 0.088 | 1 | 0.787 |
PLK1 |
0.611 | -0.035 | -2 | 0.081 |
DNAPK |
0.611 | 0.027 | 1 | 0.642 |
SRPK2 |
0.611 | -0.020 | -3 | 0.056 |
ATM |
0.610 | -0.015 | 1 | 0.700 |
CDK5 |
0.610 | 0.090 | 1 | 0.840 |
CK1A2 |
0.610 | -0.057 | -3 | 0.026 |
MLK2 |
0.610 | -0.036 | 2 | 0.769 |
PKACB |
0.610 | -0.071 | -2 | 0.051 |
NEK2 |
0.610 | 0.054 | 2 | 0.753 |
TBK1 |
0.610 | -0.047 | 1 | 0.643 |
CDK14 |
0.610 | 0.095 | 1 | 0.810 |
GAK |
0.610 | 0.032 | 1 | 0.795 |
MSK1 |
0.609 | -0.061 | -3 | 0.070 |
AURC |
0.609 | -0.058 | -2 | 0.051 |
MARK4 |
0.609 | -0.052 | 4 | 0.822 |
AKT2 |
0.608 | -0.064 | -3 | 0.057 |
NDR1 |
0.608 | -0.105 | -3 | 0.076 |
GRK3 |
0.608 | -0.051 | -2 | 0.058 |
RSK4 |
0.608 | -0.061 | -3 | 0.059 |
CDK10 |
0.608 | 0.088 | 1 | 0.803 |
CK1E |
0.608 | -0.070 | -3 | 0.030 |
YSK4 |
0.608 | -0.072 | 1 | 0.679 |
PASK |
0.607 | -0.045 | -3 | 0.083 |
RSK3 |
0.607 | -0.065 | -3 | 0.079 |
MOK |
0.607 | 0.024 | 1 | 0.849 |
CDK2 |
0.607 | 0.074 | 1 | 0.843 |
TGFBR2 |
0.606 | -0.099 | -2 | 0.077 |
PKACG |
0.606 | -0.093 | -2 | 0.073 |
BCKDK |
0.606 | -0.045 | -1 | 0.578 |
PRKX |
0.606 | -0.066 | -3 | 0.030 |
ANKRD3 |
0.606 | -0.117 | 1 | 0.760 |
GCN2 |
0.605 | -0.058 | 2 | 0.772 |
AMPKA1 |
0.605 | -0.097 | -3 | 0.096 |
TSSK2 |
0.605 | -0.092 | -5 | 0.500 |
WNK1 |
0.604 | -0.105 | -2 | 0.090 |
GRK4 |
0.604 | -0.119 | -2 | 0.079 |
PKR |
0.604 | -0.062 | 1 | 0.748 |
CDK16 |
0.604 | 0.091 | 1 | 0.761 |
MYLK4 |
0.604 | -0.078 | -2 | 0.083 |
NEK5 |
0.604 | 0.030 | 1 | 0.734 |
MSK2 |
0.604 | -0.079 | -3 | 0.067 |
CAMK1D |
0.604 | -0.058 | -3 | 0.049 |
PLK3 |
0.603 | -0.038 | 2 | 0.759 |
PKACA |
0.603 | -0.074 | -2 | 0.043 |
CAMK4 |
0.603 | -0.099 | -3 | 0.103 |
SMMLCK |
0.603 | -0.078 | -3 | 0.101 |
AURB |
0.602 | -0.072 | -2 | 0.050 |
PKN2 |
0.602 | -0.086 | -3 | 0.097 |
TLK2 |
0.602 | -0.098 | 1 | 0.696 |
MLK1 |
0.602 | -0.117 | 2 | 0.743 |
AURA |
0.602 | -0.070 | -2 | 0.038 |
RIPK3 |
0.602 | -0.082 | 3 | 0.748 |
AMPKA2 |
0.601 | -0.095 | -3 | 0.080 |
P70S6K |
0.601 | -0.061 | -3 | 0.081 |
CDK3 |
0.601 | 0.085 | 1 | 0.768 |
CAMK1G |
0.601 | -0.048 | -3 | 0.107 |
MPSK1 |
0.600 | -0.018 | 1 | 0.734 |
CK2A2 |
0.600 | 0.035 | 1 | 0.687 |
DCAMKL1 |
0.600 | -0.071 | -3 | 0.074 |
TSSK1 |
0.600 | -0.084 | -3 | 0.096 |
MST4 |
0.600 | -0.089 | 2 | 0.804 |
PBK |
0.600 | 0.020 | 1 | 0.732 |
RIPK1 |
0.599 | -0.105 | 1 | 0.711 |
NUAK1 |
0.599 | -0.066 | -3 | 0.098 |
QSK |
0.598 | -0.060 | 4 | 0.794 |
PLK2 |
0.598 | -0.015 | -3 | 0.108 |
PERK |
0.598 | -0.073 | -2 | 0.124 |
MEKK1 |
0.598 | -0.037 | 1 | 0.709 |
DRAK1 |
0.598 | -0.021 | 1 | 0.715 |
MEKK3 |
0.598 | -0.107 | 1 | 0.716 |
CHK2 |
0.598 | -0.043 | -3 | 0.052 |
CAMK1A |
0.598 | -0.044 | -3 | 0.051 |
CDK6 |
0.597 | 0.107 | 1 | 0.794 |
MEK5 |
0.597 | -0.132 | 2 | 0.777 |
NEK4 |
0.597 | 0.086 | 1 | 0.689 |
TAK1 |
0.597 | -0.015 | 1 | 0.721 |
NIM1 |
0.597 | -0.047 | 3 | 0.783 |
SGK1 |
0.597 | -0.073 | -3 | 0.035 |
MELK |
0.597 | -0.091 | -3 | 0.082 |
SGK3 |
0.597 | -0.099 | -3 | 0.064 |
PAK1 |
0.596 | -0.109 | -2 | 0.065 |
WNK3 |
0.596 | -0.117 | 1 | 0.712 |
PAK6 |
0.596 | -0.046 | -2 | 0.082 |
TLK1 |
0.596 | -0.111 | -2 | 0.081 |
PKG2 |
0.596 | -0.096 | -2 | 0.053 |
GSK3A |
0.595 | 0.022 | 4 | 0.536 |
MST2 |
0.595 | -0.084 | 1 | 0.721 |
NEK11 |
0.595 | -0.025 | 1 | 0.708 |
MARK2 |
0.595 | -0.035 | 4 | 0.723 |
DAPK3 |
0.595 | -0.093 | -3 | 0.072 |
PAK3 |
0.594 | -0.106 | -2 | 0.081 |
QIK |
0.594 | -0.102 | -3 | 0.113 |
CHAK1 |
0.594 | -0.018 | 2 | 0.726 |
FAM20C |
0.594 | 0.004 | 2 | 0.619 |
GSK3B |
0.594 | 0.023 | 4 | 0.529 |
HRI |
0.594 | -0.091 | -2 | 0.103 |
MARK1 |
0.594 | -0.042 | 4 | 0.774 |
CK1A |
0.594 | -0.052 | -3 | 0.013 |
LRRK2 |
0.594 | -0.017 | 2 | 0.789 |
SIK |
0.594 | -0.082 | -3 | 0.086 |
BIKE |
0.593 | 0.085 | 1 | 0.701 |
NEK1 |
0.593 | 0.065 | 1 | 0.698 |
DAPK1 |
0.593 | -0.081 | -3 | 0.071 |
CRIK |
0.593 | -0.051 | -3 | 0.059 |
CDK4 |
0.593 | 0.092 | 1 | 0.783 |
MARK3 |
0.593 | -0.049 | 4 | 0.758 |
AKT1 |
0.593 | -0.081 | -3 | 0.055 |
PKCD |
0.592 | -0.108 | 2 | 0.710 |
MLK3 |
0.592 | -0.072 | 2 | 0.664 |
GCK |
0.592 | -0.085 | 1 | 0.723 |
NEK8 |
0.592 | -0.042 | 2 | 0.747 |
MEKK2 |
0.591 | -0.122 | 2 | 0.751 |
AKT3 |
0.591 | -0.070 | -3 | 0.039 |
MRCKA |
0.591 | -0.090 | -3 | 0.065 |
CK2A1 |
0.591 | 0.026 | 1 | 0.668 |
MEK2 |
0.591 | 0.018 | 2 | 0.774 |
TTBK2 |
0.591 | -0.125 | 2 | 0.672 |
DMPK1 |
0.591 | -0.073 | -3 | 0.056 |
MST3 |
0.590 | -0.100 | 2 | 0.780 |
PAK2 |
0.590 | -0.121 | -2 | 0.072 |
IRAK1 |
0.590 | 0.008 | -1 | 0.514 |
MNK2 |
0.590 | -0.100 | -2 | 0.075 |
PDK1 |
0.589 | -0.087 | 1 | 0.712 |
HPK1 |
0.589 | -0.062 | 1 | 0.708 |
TAO3 |
0.589 | -0.129 | 1 | 0.714 |
NEK3 |
0.589 | 0.085 | 1 | 0.664 |
MLK4 |
0.589 | -0.096 | 2 | 0.652 |
ERK7 |
0.589 | 0.029 | 2 | 0.476 |
MRCKB |
0.588 | -0.087 | -3 | 0.066 |
ZAK |
0.587 | -0.130 | 1 | 0.679 |
PKCZ |
0.587 | -0.098 | 2 | 0.708 |
MINK |
0.587 | -0.058 | 1 | 0.696 |
WNK4 |
0.587 | -0.104 | -2 | 0.105 |
BUB1 |
0.586 | -0.039 | -5 | 0.500 |
TAO2 |
0.586 | -0.093 | 2 | 0.781 |
BRSK1 |
0.586 | -0.086 | -3 | 0.090 |
MNK1 |
0.586 | -0.113 | -2 | 0.069 |
DCAMKL2 |
0.586 | -0.089 | -3 | 0.083 |
HGK |
0.586 | -0.057 | 3 | 0.850 |
ROCK2 |
0.586 | -0.099 | -3 | 0.065 |
PKCB |
0.585 | -0.093 | 2 | 0.654 |
PKCA |
0.585 | -0.084 | 2 | 0.644 |
PAK5 |
0.584 | -0.075 | -2 | 0.067 |
TNIK |
0.584 | -0.073 | 3 | 0.852 |
AAK1 |
0.584 | 0.079 | 1 | 0.625 |
EEF2K |
0.583 | -0.062 | 3 | 0.814 |
MST1 |
0.583 | -0.104 | 1 | 0.696 |
LOK |
0.583 | -0.074 | -2 | 0.133 |
PKCG |
0.583 | -0.107 | 2 | 0.653 |
CK1G1 |
0.582 | -0.093 | -3 | 0.020 |
PKCI |
0.582 | -0.055 | 2 | 0.664 |
SLK |
0.582 | -0.106 | -2 | 0.090 |
SNRK |
0.581 | -0.092 | 2 | 0.625 |
IRAK4 |
0.581 | -0.038 | 1 | 0.695 |
SSTK |
0.581 | -0.085 | 4 | 0.786 |
IRE1 |
0.581 | -0.107 | 1 | 0.701 |
MEKK6 |
0.581 | -0.102 | 1 | 0.715 |
BRSK2 |
0.580 | -0.102 | -3 | 0.095 |
PKCH |
0.580 | -0.112 | 2 | 0.635 |
PHKG1 |
0.580 | -0.101 | -3 | 0.076 |
MAP3K15 |
0.579 | -0.097 | 1 | 0.670 |
KHS1 |
0.578 | -0.084 | 1 | 0.692 |
VRK1 |
0.578 | -0.121 | 2 | 0.778 |
PAK4 |
0.578 | -0.067 | -2 | 0.065 |
ROCK1 |
0.577 | -0.097 | -3 | 0.064 |
PKN1 |
0.577 | -0.070 | -3 | 0.085 |
IRE2 |
0.576 | -0.106 | 2 | 0.664 |
ALPHAK3 |
0.576 | -0.051 | -1 | 0.617 |
CK1G3 |
0.575 | -0.078 | -3 | 0.008 |
KHS2 |
0.575 | -0.083 | 1 | 0.709 |
RIPK2 |
0.575 | -0.069 | 1 | 0.635 |
STK33 |
0.574 | -0.045 | 2 | 0.586 |
PLK4 |
0.574 | -0.117 | 2 | 0.595 |
YSK1 |
0.573 | -0.078 | 2 | 0.746 |
PKG1 |
0.572 | -0.096 | -2 | 0.039 |
TTBK1 |
0.572 | -0.083 | 2 | 0.589 |
PKCE |
0.572 | -0.090 | 2 | 0.636 |
OSR1 |
0.571 | -0.137 | 2 | 0.758 |
PHKG2 |
0.571 | -0.081 | -3 | 0.093 |
MYO3B |
0.571 | -0.042 | 2 | 0.758 |
CK1G2 |
0.570 | -0.063 | -3 | 0.018 |
PKCT |
0.569 | -0.117 | 2 | 0.646 |
ASK1 |
0.565 | -0.089 | 1 | 0.658 |
MYO3A |
0.565 | -0.072 | 1 | 0.684 |
TTK |
0.565 | -0.149 | -2 | 0.072 |
STLK3 |
0.561 | -0.119 | 1 | 0.644 |
BMPR2_TYR |
0.554 | 0.047 | -1 | 0.723 |
HASPIN |
0.554 | -0.095 | -1 | 0.463 |
TAO1 |
0.553 | -0.115 | 1 | 0.631 |
YANK3 |
0.552 | -0.055 | 2 | 0.405 |
MAP2K6_TYR |
0.549 | -0.012 | -1 | 0.692 |
PDHK3_TYR |
0.549 | -0.045 | 4 | 0.881 |
MAP2K4_TYR |
0.549 | -0.013 | -1 | 0.666 |
PDHK4_TYR |
0.545 | -0.064 | 2 | 0.854 |
PDHK1_TYR |
0.545 | -0.057 | -1 | 0.696 |
TESK1_TYR |
0.541 | -0.092 | 3 | 0.891 |
PKMYT1_TYR |
0.541 | -0.056 | 3 | 0.861 |
MAP2K7_TYR |
0.538 | -0.156 | 2 | 0.821 |
EPHA6 |
0.536 | -0.009 | -1 | 0.702 |
YANK2 |
0.535 | -0.064 | 2 | 0.416 |
LIMK2_TYR |
0.533 | -0.083 | -3 | 0.100 |
PINK1_TYR |
0.533 | -0.145 | 1 | 0.766 |
EPHA4 |
0.529 | -0.032 | 2 | 0.764 |
PTK2 |
0.529 | 0.040 | -1 | 0.726 |
EPHB4 |
0.529 | -0.079 | -1 | 0.643 |
SYK |
0.527 | -0.017 | -1 | 0.709 |
FGR |
0.527 | -0.108 | 1 | 0.786 |
FER |
0.526 | -0.084 | 1 | 0.799 |
LIMK1_TYR |
0.526 | -0.143 | 2 | 0.798 |
SRMS |
0.526 | -0.046 | 1 | 0.780 |
DDR1 |
0.525 | -0.105 | 4 | 0.801 |
HCK |
0.524 | -0.056 | -1 | 0.652 |
LCK |
0.523 | -0.053 | -1 | 0.674 |
TYK2 |
0.523 | -0.115 | 1 | 0.708 |
TXK |
0.523 | -0.076 | 1 | 0.784 |
EPHB3 |
0.522 | -0.065 | -1 | 0.634 |
JAK3 |
0.522 | -0.097 | 1 | 0.698 |
RET |
0.522 | -0.176 | 1 | 0.713 |
BLK |
0.522 | -0.045 | -1 | 0.674 |
EPHB1 |
0.521 | -0.078 | 1 | 0.772 |
EPHB2 |
0.521 | -0.068 | -1 | 0.629 |
FYN |
0.521 | -0.041 | -1 | 0.678 |
JAK2 |
0.521 | -0.114 | 1 | 0.711 |
ABL2 |
0.519 | -0.084 | -1 | 0.589 |
INSRR |
0.519 | -0.100 | 3 | 0.749 |
YES1 |
0.519 | -0.108 | -1 | 0.616 |
ABL1 |
0.517 | -0.079 | -1 | 0.571 |
MST1R |
0.517 | -0.170 | 3 | 0.812 |
FLT1 |
0.516 | -0.102 | -1 | 0.680 |
ITK |
0.516 | -0.099 | -1 | 0.598 |
EPHA3 |
0.515 | -0.066 | 2 | 0.731 |
TNNI3K_TYR |
0.515 | -0.063 | 1 | 0.732 |
ROS1 |
0.515 | -0.152 | 3 | 0.764 |
NEK10_TYR |
0.515 | -0.062 | 1 | 0.595 |
CSF1R |
0.514 | -0.145 | 3 | 0.791 |
JAK1 |
0.514 | -0.031 | 1 | 0.653 |
TYRO3 |
0.514 | -0.167 | 3 | 0.794 |
NTRK1 |
0.513 | -0.083 | -1 | 0.604 |
TEK |
0.513 | -0.082 | 3 | 0.733 |
KIT |
0.513 | -0.129 | 3 | 0.794 |
FGFR2 |
0.512 | -0.139 | 3 | 0.804 |
BMX |
0.512 | -0.077 | -1 | 0.544 |
EPHA7 |
0.512 | -0.067 | 2 | 0.753 |
TNK2 |
0.512 | -0.097 | 3 | 0.761 |
LYN |
0.511 | -0.076 | 3 | 0.713 |
EPHA8 |
0.510 | -0.068 | -1 | 0.661 |
EPHA5 |
0.510 | -0.070 | 2 | 0.746 |
FGFR1 |
0.509 | -0.108 | 3 | 0.768 |
MET |
0.509 | -0.136 | 3 | 0.790 |
SRC |
0.509 | -0.080 | -1 | 0.633 |
ERBB2 |
0.508 | -0.103 | 1 | 0.679 |
KDR |
0.508 | -0.144 | 3 | 0.757 |
FGFR3 |
0.508 | -0.117 | 3 | 0.775 |
BTK |
0.508 | -0.119 | -1 | 0.524 |
EGFR |
0.506 | -0.074 | 1 | 0.598 |
DDR2 |
0.505 | -0.100 | 3 | 0.734 |
FLT3 |
0.505 | -0.144 | 3 | 0.788 |
MERTK |
0.505 | -0.116 | 3 | 0.786 |
PTK6 |
0.505 | -0.147 | -1 | 0.508 |
TEC |
0.505 | -0.102 | -1 | 0.498 |
PTK2B |
0.505 | -0.062 | -1 | 0.538 |
NTRK3 |
0.505 | -0.115 | -1 | 0.583 |
PDGFRB |
0.504 | -0.166 | 3 | 0.799 |
FLT4 |
0.504 | -0.104 | 3 | 0.756 |
WEE1_TYR |
0.504 | -0.099 | -1 | 0.523 |
PDGFRA |
0.503 | -0.129 | 3 | 0.796 |
NTRK2 |
0.503 | -0.123 | 3 | 0.754 |
INSR |
0.503 | -0.107 | 3 | 0.724 |
EPHA2 |
0.503 | -0.057 | -1 | 0.636 |
FRK |
0.502 | -0.106 | -1 | 0.646 |
MATK |
0.502 | -0.118 | -1 | 0.525 |
LTK |
0.502 | -0.106 | 3 | 0.742 |
ZAP70 |
0.501 | -0.058 | -1 | 0.640 |
TNK1 |
0.501 | -0.144 | 3 | 0.781 |
EPHA1 |
0.501 | -0.113 | 3 | 0.766 |
ALK |
0.501 | -0.114 | 3 | 0.714 |
AXL |
0.500 | -0.156 | 3 | 0.780 |
CSK |
0.500 | -0.118 | 2 | 0.757 |
FGFR4 |
0.499 | -0.104 | -1 | 0.584 |
ERBB4 |
0.497 | -0.064 | 1 | 0.636 |
IGF1R |
0.492 | -0.100 | 3 | 0.667 |
MUSK |
0.490 | -0.071 | 1 | 0.592 |
FES |
0.488 | -0.065 | -1 | 0.508 |