Motif 1217 (n=55)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYH1 | C15orf38-AP3S2 | S2 | ochoa | Arpin | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000256|ARBA:ARBA00025605}. |
| A0A1W2PNV4 | None | S2 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A6NMY6 | ANXA2P2 | S2 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| C4P0D8 | TSNAX-DISC1 | S2 | ochoa | Disrupted in schizophrenia 1 isoform 51 (TSNAX-DISC1 readthrough (NMD candidate)) | None |
| O15258 | RER1 | S2 | ochoa | Protein RER1 | Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}. |
| O15400 | STX7 | S2 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43719 | HTATSF1 | S2 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O75204 | TMEM127 | Y2 | ochoa | Transmembrane protein 127 | Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000269|PubMed:20154675}. |
| O75436 | VPS26A | S2 | ochoa | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| P00918 | CA2 | S2 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P07355 | ANXA2 | S2 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P09914 | IFIT1 | S2 | ochoa | Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1) | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486). {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:28251928, ECO:0000269|PubMed:36285486, ECO:0000269|PubMed:39009378}. |
| P11474 | ESRRA | S2 | ochoa | Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}. |
| P20340 | RAB6A | S2 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P37198 | NUP62 | S2 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P49790 | NUP153 | S3 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49840 | GSK3A | S2 | ochoa | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). {ECO:0000250|UniProtKB:P18265, ECO:0000250|UniProtKB:P49841, ECO:0000250|UniProtKB:Q2NL51, ECO:0000269|PubMed:10868943, ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:11749387, ECO:0000303|PubMed:17478001, ECO:0000303|PubMed:19366350}. |
| P52926 | HMGA2 | S2 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| P62995 | TRA2B | S2 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| Q07955 | SRSF1 | S2 | ochoa | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q13153 | PAK1 | S2 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13177 | PAK2 | S2 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13303 | KCNAB2 | Y2 | ochoa | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}. |
| Q13829 | TNFAIP1 | S2 | ochoa | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}. |
| Q14194 | CRMP1 | S2 | ochoa | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q16555 | DPYSL2 | S2 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16637 | SMN1 | S4 | ochoa|psp | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q53S08 | RAB6D | S2 | ochoa | Ras-related protein Rab-6D (EC 3.6.5.2) (Rab6-like protein WTH3DI) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20340}. |
| Q7L9L4 | MOB1B | S2 | ochoa | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7LFL8 | CXXC5 | S2 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7Z6K5 | ARPIN | S2 | ochoa | Arpin (Arp2/3 inhibition protein) | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}. |
| Q8N461 | FBXL16 | S2 | ochoa | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q8TD19 | NEK9 | S2 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q92747 | ARPC1A | S2 | ochoa | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|PubMed:8978670}. |
| Q92945 | KHSRP | S2 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q969L2 | MAL2 | S2 | ochoa | Protein MAL2 | Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}. |
| Q99598 | TSNAX | S2 | ochoa | Translin-associated protein X (Translin-associated factor X) | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}. |
| Q9H0N0 | RAB6C | S2 | ochoa | Ras-related protein Rab-6C (EC 3.6.5.2) (Rab6-like protein WTH3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB6C may be involved in the regulation of centrosome duplication and cell cycle progression. {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17426708, ECO:0000269|PubMed:18992151, ECO:0000269|PubMed:20064528}. |
| Q9H0W8 | SMG9 | S2 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H2U1 | DHX36 | S2 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H8S9 | MOB1A | S2 | ochoa | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9NRW1 | RAB6B | S2 | ochoa | Ras-related protein Rab-6B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}. |
| Q9NZN5 | ARHGEF12 | S2 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P0J7 | KCMF1 | S2 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9UM13 | ANAPC10 | T2 | ochoa | Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UPR3 | SMG5 | S2 | ochoa | Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}. |
| P0C0S8 | H2AC11 | S2 | GPS6|SIGNOR|ELM|EPSD | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6FI13 | H2AC18 | S2 | GPS6|EPSD | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L7L0 | H2AC25 | S2 | GPS6|SIGNOR|iPTMNet|EPSD | Histone H2A type 3 (H2A-clustered histone 25) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8IUE6 | H2AC21 | S2 | GPS6|EPSD | Histone H2A type 2-B (H2A-clustered histone 21) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93077 | H2AC6 | S2 | GPS6|EPSD | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96KK5 | H2AC12 | S2 | GPS6|EPSD | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96QV6 | H2AC1 | S2 | GPS6|EPSD | Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99878 | H2AC14 | S2 | GPS6|EPSD | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62805 | H4C1 | S2 | EPSD | Histone H4 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3214858 | RMTs methylate histone arginines | 2.209344e-14 | 13.656 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.260769e-12 | 11.899 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.501910e-12 | 11.187 |
| R-HSA-9610379 | HCMV Late Events | 1.548116e-10 | 9.810 |
| R-HSA-3214847 | HATs acetylate histones | 8.440201e-10 | 9.074 |
| R-HSA-9609690 | HCMV Early Events | 1.313571e-09 | 8.882 |
| R-HSA-5689603 | UCH proteinases | 2.405973e-09 | 8.619 |
| R-HSA-9609646 | HCMV Infection | 1.352780e-08 | 7.869 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.983941e-08 | 7.047 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.765376e-08 | 7.010 |
| R-HSA-4839726 | Chromatin organization | 1.520208e-07 | 6.818 |
| R-HSA-211000 | Gene Silencing by RNA | 6.400119e-07 | 6.194 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.058193e-06 | 5.975 |
| R-HSA-68875 | Mitotic Prophase | 1.400242e-06 | 5.854 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.807651e-06 | 5.743 |
| R-HSA-5688426 | Deubiquitination | 1.899113e-06 | 5.721 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.148438e-05 | 4.940 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.148438e-05 | 4.940 |
| R-HSA-373755 | Semaphorin interactions | 1.190534e-05 | 4.924 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.112518e-05 | 4.954 |
| R-HSA-5334118 | DNA methylation | 1.444295e-05 | 4.840 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.988458e-05 | 4.701 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.199414e-05 | 4.658 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.670035e-05 | 4.573 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.670035e-05 | 4.573 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.210619e-05 | 4.493 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.509075e-05 | 4.455 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.509075e-05 | 4.455 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.670272e-05 | 4.435 |
| R-HSA-73927 | Depurination | 3.827357e-05 | 4.417 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.103025e-05 | 4.387 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.526627e-05 | 4.344 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.526627e-05 | 4.344 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.909254e-05 | 4.309 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.744677e-05 | 4.241 |
| R-HSA-73928 | Depyrimidination | 5.744677e-05 | 4.241 |
| R-HSA-9710421 | Defective pyroptosis | 6.199176e-05 | 4.208 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.917026e-05 | 4.160 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 7.186086e-05 | 4.144 |
| R-HSA-774815 | Nucleosome assembly | 7.186086e-05 | 4.144 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 7.720261e-05 | 4.112 |
| R-HSA-912446 | Meiotic recombination | 1.083444e-04 | 3.965 |
| R-HSA-1221632 | Meiotic synapsis | 1.230426e-04 | 3.910 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.155240e-04 | 3.937 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.230426e-04 | 3.910 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.309097e-04 | 3.883 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.462504e-04 | 3.835 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.859757e-04 | 3.731 |
| R-HSA-2559583 | Cellular Senescence | 1.715787e-04 | 3.766 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.660571e-04 | 3.780 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.699279e-04 | 3.770 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.859757e-04 | 3.731 |
| R-HSA-9824446 | Viral Infection Pathways | 1.955666e-04 | 3.709 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.075641e-04 | 3.683 |
| R-HSA-68886 | M Phase | 2.424757e-04 | 3.615 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.432549e-04 | 3.614 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.560751e-04 | 3.592 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.122489e-04 | 3.505 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.831624e-04 | 3.548 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.974505e-04 | 3.527 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.122489e-04 | 3.505 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.275682e-04 | 3.485 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.275682e-04 | 3.485 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.123503e-04 | 3.385 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.123503e-04 | 3.385 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.502836e-04 | 3.347 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.906441e-04 | 3.309 |
| R-HSA-977225 | Amyloid fiber formation | 5.117618e-04 | 3.291 |
| R-HSA-1500620 | Meiosis | 6.027382e-04 | 3.220 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.789963e-04 | 3.237 |
| R-HSA-8939211 | ESR-mediated signaling | 6.619710e-04 | 3.179 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.046521e-04 | 3.152 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.781095e-04 | 3.169 |
| R-HSA-69306 | DNA Replication | 7.047439e-04 | 3.152 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 7.180566e-04 | 3.144 |
| R-HSA-73884 | Base Excision Repair | 7.599321e-04 | 3.119 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.886917e-04 | 3.103 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.560497e-04 | 3.020 |
| R-HSA-157579 | Telomere Maintenance | 1.047111e-03 | 2.980 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.235903e-03 | 2.908 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.235903e-03 | 2.908 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.359964e-03 | 2.866 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.359964e-03 | 2.866 |
| R-HSA-428540 | Activation of RAC1 | 1.788844e-03 | 2.747 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.555638e-03 | 2.593 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.489302e-03 | 2.604 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.285583e-03 | 2.641 |
| R-HSA-73886 | Chromosome Maintenance | 2.354410e-03 | 2.628 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.285583e-03 | 2.641 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.481902e-03 | 2.605 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.081497e-03 | 2.682 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.568263e-03 | 2.590 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.681936e-03 | 2.572 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.681936e-03 | 2.572 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.681936e-03 | 2.572 |
| R-HSA-191859 | snRNP Assembly | 2.710434e-03 | 2.567 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.710434e-03 | 2.567 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.719360e-03 | 2.566 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.839990e-03 | 2.547 |
| R-HSA-597592 | Post-translational protein modification | 2.858181e-03 | 2.544 |
| R-HSA-1474165 | Reproduction | 3.114720e-03 | 2.507 |
| R-HSA-2262752 | Cellular responses to stress | 3.179068e-03 | 2.498 |
| R-HSA-5663205 | Infectious disease | 3.425272e-03 | 2.465 |
| R-HSA-2028269 | Signaling by Hippo | 3.777663e-03 | 2.423 |
| R-HSA-3928664 | Ephrin signaling | 4.118037e-03 | 2.385 |
| R-HSA-157118 | Signaling by NOTCH | 4.336177e-03 | 2.363 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.598647e-03 | 2.337 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.862700e-03 | 2.313 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.919179e-03 | 2.308 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.322727e-03 | 2.274 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.543915e-03 | 2.256 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.145879e-03 | 2.211 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 8.164230e-03 | 2.088 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.750066e-03 | 2.011 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.724200e-03 | 2.112 |
| R-HSA-8953854 | Metabolism of RNA | 8.039725e-03 | 2.095 |
| R-HSA-1640170 | Cell Cycle | 9.751754e-03 | 2.011 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.958345e-03 | 2.099 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.641549e-03 | 2.063 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 6.878338e-03 | 2.163 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.101753e-03 | 2.091 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.101753e-03 | 2.091 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.630197e-03 | 2.016 |
| R-HSA-168256 | Immune System | 6.881841e-03 | 2.162 |
| R-HSA-195721 | Signaling by WNT | 9.907977e-03 | 2.004 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.027229e-02 | 1.988 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.027229e-02 | 1.988 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.135317e-02 | 1.945 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.135317e-02 | 1.945 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.188273e-02 | 1.925 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.191160e-02 | 1.924 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.191160e-02 | 1.924 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.248190e-02 | 1.904 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.263839e-02 | 1.898 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.426293e-02 | 1.846 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.487965e-02 | 1.827 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.550771e-02 | 1.809 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.550771e-02 | 1.809 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.614703e-02 | 1.792 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.614703e-02 | 1.792 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.614703e-02 | 1.792 |
| R-HSA-202433 | Generation of second messenger molecules | 1.614703e-02 | 1.792 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 1.626281e-02 | 1.789 |
| R-HSA-418990 | Adherens junctions interactions | 1.664681e-02 | 1.779 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.679750e-02 | 1.775 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.679750e-02 | 1.775 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.854803e-02 | 1.732 |
| R-HSA-8854214 | TBC/RABGAPs | 1.881481e-02 | 1.726 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.929363e-02 | 1.715 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.950890e-02 | 1.710 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.021365e-02 | 1.694 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.092896e-02 | 1.679 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.165475e-02 | 1.664 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.239091e-02 | 1.650 |
| R-HSA-421270 | Cell-cell junction organization | 2.533894e-02 | 1.596 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 3.622542e-02 | 1.441 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 2.828871e-02 | 1.548 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.243139e-02 | 1.280 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.782670e-02 | 1.556 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.200038e-02 | 1.495 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.286305e-02 | 1.483 |
| R-HSA-164944 | Nef and signal transduction | 3.622542e-02 | 1.441 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 3.622542e-02 | 1.441 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.191709e-02 | 1.285 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.373482e-02 | 1.472 |
| R-HSA-1266738 | Developmental Biology | 2.681194e-02 | 1.572 |
| R-HSA-422475 | Axon guidance | 2.844394e-02 | 1.546 |
| R-HSA-9675108 | Nervous system development | 3.703317e-02 | 1.431 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.906829e-02 | 1.537 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.389270e-02 | 1.470 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.646963e-02 | 1.577 |
| R-HSA-446728 | Cell junction organization | 3.416820e-02 | 1.466 |
| R-HSA-1500931 | Cell-Cell communication | 4.929769e-02 | 1.307 |
| R-HSA-9635465 | Suppression of apoptosis | 5.578895e-02 | 1.253 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 5.578895e-02 | 1.253 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.610702e-02 | 1.251 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.717263e-02 | 1.243 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.728620e-02 | 1.242 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.824533e-02 | 1.235 |
| R-HSA-162582 | Signal Transduction | 6.255607e-02 | 1.204 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 6.350439e-02 | 1.197 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 6.350439e-02 | 1.197 |
| R-HSA-72172 | mRNA Splicing | 6.458674e-02 | 1.190 |
| R-HSA-392499 | Metabolism of proteins | 6.470921e-02 | 1.189 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.482656e-02 | 1.188 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.500676e-02 | 1.187 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.733879e-02 | 1.172 |
| R-HSA-9683610 | Maturation of nucleoprotein | 6.733879e-02 | 1.172 |
| R-HSA-1280218 | Adaptive Immune System | 6.962349e-02 | 1.157 |
| R-HSA-397014 | Muscle contraction | 7.015431e-02 | 1.154 |
| R-HSA-73894 | DNA Repair | 7.076551e-02 | 1.150 |
| R-HSA-70171 | Glycolysis | 7.631533e-02 | 1.117 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.834476e-02 | 1.106 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.868612e-02 | 1.104 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 7.874946e-02 | 1.104 |
| R-HSA-176412 | Phosphorylation of the APC/C | 7.874946e-02 | 1.104 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 7.874946e-02 | 1.104 |
| R-HSA-162906 | HIV Infection | 8.115789e-02 | 1.091 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.191690e-02 | 1.087 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 8.252238e-02 | 1.083 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 8.252238e-02 | 1.083 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 8.252238e-02 | 1.083 |
| R-HSA-913531 | Interferon Signaling | 8.421241e-02 | 1.075 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 8.628008e-02 | 1.064 |
| R-HSA-202403 | TCR signaling | 8.963301e-02 | 1.048 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.212447e-02 | 1.036 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.212447e-02 | 1.036 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 9.212447e-02 | 1.036 |
| R-HSA-1483249 | Inositol phosphate metabolism | 9.212447e-02 | 1.036 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 9.375006e-02 | 1.028 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 9.375006e-02 | 1.028 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 9.375006e-02 | 1.028 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 9.375006e-02 | 1.028 |
| R-HSA-9694631 | Maturation of nucleoprotein | 9.375006e-02 | 1.028 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 9.746247e-02 | 1.011 |
| R-HSA-445144 | Signal transduction by L1 | 9.746247e-02 | 1.011 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.844092e-02 | 1.007 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.844092e-02 | 1.007 |
| R-HSA-373760 | L1CAM interactions | 9.971879e-02 | 1.001 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.010014e-01 | 0.996 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.010014e-01 | 0.996 |
| R-HSA-70326 | Glucose metabolism | 1.010014e-01 | 0.996 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.011599e-01 | 0.995 |
| R-HSA-3371556 | Cellular response to heat stress | 1.061777e-01 | 0.974 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 1.085100e-01 | 0.965 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.121629e-01 | 0.950 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.121629e-01 | 0.950 |
| R-HSA-1643685 | Disease | 1.126483e-01 | 0.948 |
| R-HSA-194138 | Signaling by VEGF | 1.127474e-01 | 0.948 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.158010e-01 | 0.936 |
| R-HSA-3214842 | HDMs demethylate histones | 1.194244e-01 | 0.923 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.194244e-01 | 0.923 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.230332e-01 | 0.910 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.234719e-01 | 0.908 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 1.302072e-01 | 0.885 |
| R-HSA-6798695 | Neutrophil degranulation | 1.327751e-01 | 0.877 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.372097e-01 | 0.863 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.373233e-01 | 0.862 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.399975e-01 | 0.854 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.399975e-01 | 0.854 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.408599e-01 | 0.851 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.443821e-01 | 0.840 |
| R-HSA-397795 | G-protein beta:gamma signalling | 1.478902e-01 | 0.830 |
| R-HSA-169911 | Regulation of Apoptosis | 1.583295e-01 | 0.800 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.583295e-01 | 0.800 |
| R-HSA-381042 | PERK regulates gene expression | 1.583295e-01 | 0.800 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.584059e-01 | 0.800 |
| R-HSA-162587 | HIV Life Cycle | 1.612784e-01 | 0.792 |
| R-HSA-1296072 | Voltage gated Potassium channels | 1.652190e-01 | 0.782 |
| R-HSA-5619102 | SLC transporter disorders | 1.757802e-01 | 0.755 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.788318e-01 | 0.748 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.788318e-01 | 0.748 |
| R-HSA-72306 | tRNA processing | 1.816399e-01 | 0.741 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.822007e-01 | 0.739 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.831096e-01 | 0.737 |
| R-HSA-168249 | Innate Immune System | 1.864018e-01 | 0.730 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.875294e-01 | 0.727 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.888977e-01 | 0.724 |
| R-HSA-168255 | Influenza Infection | 1.949295e-01 | 0.710 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.988420e-01 | 0.701 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.988420e-01 | 0.701 |
| R-HSA-75153 | Apoptotic execution phase | 1.988420e-01 | 0.701 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.021301e-01 | 0.694 |
| R-HSA-437239 | Recycling pathway of L1 | 2.021301e-01 | 0.694 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.054048e-01 | 0.687 |
| R-HSA-9679506 | SARS-CoV Infections | 2.106675e-01 | 0.676 |
| R-HSA-72187 | mRNA 3'-end processing | 2.183719e-01 | 0.661 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.183719e-01 | 0.661 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.183719e-01 | 0.661 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.215809e-01 | 0.654 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.215809e-01 | 0.654 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.247770e-01 | 0.648 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.247770e-01 | 0.648 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.263746e-01 | 0.645 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.279602e-01 | 0.642 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.309030e-01 | 0.637 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.309030e-01 | 0.637 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.311305e-01 | 0.636 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.311305e-01 | 0.636 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.405647e-01 | 0.619 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.467907e-01 | 0.608 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.467907e-01 | 0.608 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.498848e-01 | 0.602 |
| R-HSA-68882 | Mitotic Anaphase | 2.521077e-01 | 0.598 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.536256e-01 | 0.596 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.651686e-01 | 0.576 |
| R-HSA-449147 | Signaling by Interleukins | 2.727832e-01 | 0.564 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.741913e-01 | 0.562 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.771745e-01 | 0.557 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.771745e-01 | 0.557 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.801457e-01 | 0.553 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.831048e-01 | 0.548 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.831048e-01 | 0.548 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.860519e-01 | 0.544 |
| R-HSA-8852135 | Protein ubiquitination | 2.889872e-01 | 0.539 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.948220e-01 | 0.530 |
| R-HSA-74160 | Gene expression (Transcription) | 2.954860e-01 | 0.529 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.977217e-01 | 0.526 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.977217e-01 | 0.526 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.991764e-01 | 0.524 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.034859e-01 | 0.518 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.063505e-01 | 0.514 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.158104e-01 | 0.501 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.425512e-01 | 0.465 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.517860e-01 | 0.454 |
| R-HSA-1296071 | Potassium Channels | 3.559735e-01 | 0.449 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.638969e-01 | 0.439 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.665166e-01 | 0.436 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.768898e-01 | 0.424 |
| R-HSA-69239 | Synthesis of DNA | 3.870956e-01 | 0.412 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.921366e-01 | 0.407 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.045611e-01 | 0.393 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.045611e-01 | 0.393 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.073804e-01 | 0.390 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.191408e-01 | 0.378 |
| R-HSA-5693538 | Homology Directed Repair | 4.191408e-01 | 0.378 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.215363e-01 | 0.375 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.262982e-01 | 0.370 |
| R-HSA-69481 | G2/M Checkpoints | 4.426627e-01 | 0.354 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.455174e-01 | 0.351 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.761972e-01 | 0.322 |
| R-HSA-9664407 | Parasite infection | 4.761972e-01 | 0.322 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.761972e-01 | 0.322 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.847989e-01 | 0.314 |
| R-HSA-69242 | S Phase | 4.953556e-01 | 0.305 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.955505e-01 | 0.305 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.056992e-01 | 0.296 |
| R-HSA-73887 | Death Receptor Signaling | 5.077427e-01 | 0.294 |
| R-HSA-1989781 | PPARA activates gene expression | 5.097779e-01 | 0.293 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.138235e-01 | 0.289 |
| R-HSA-199991 | Membrane Trafficking | 5.204169e-01 | 0.284 |
| R-HSA-109581 | Apoptosis | 5.237941e-01 | 0.281 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.277258e-01 | 0.278 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.506530e-01 | 0.259 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.632803e-01 | 0.249 |
| R-HSA-68877 | Mitotic Prometaphase | 5.830032e-01 | 0.234 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.845091e-01 | 0.233 |
| R-HSA-5357801 | Programmed Cell Death | 6.049298e-01 | 0.218 |
| R-HSA-8951664 | Neddylation | 6.303625e-01 | 0.200 |
| R-HSA-212436 | Generic Transcription Pathway | 6.342374e-01 | 0.198 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.669585e-01 | 0.176 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.121624e-01 | 0.147 |
| R-HSA-9658195 | Leishmania infection | 7.121624e-01 | 0.147 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.285178e-01 | 0.138 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.385128e-01 | 0.132 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.770103e-01 | 0.110 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.184821e-01 | 0.087 |
| R-HSA-388396 | GPCR downstream signalling | 8.433466e-01 | 0.074 |
| R-HSA-112316 | Neuronal System | 8.693567e-01 | 0.061 |
| R-HSA-372790 | Signaling by GPCR | 8.812244e-01 | 0.055 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.929278e-01 | 0.049 |
| R-HSA-109582 | Hemostasis | 9.661125e-01 | 0.015 |
| R-HSA-382551 | Transport of small molecules | 9.855945e-01 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 9.984876e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.998186e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.544 | 0.101 | -3 | 0.103 |
PRKD2 |
0.537 | 0.041 | -3 | 0.077 |
ULK1 |
0.536 | 0.336 | -3 | 0.375 |
MAPKAPK2 |
0.535 | 0.027 | -3 | 0.054 |
ERK5 |
0.534 | 0.171 | 1 | 0.739 |
MAPKAPK3 |
0.534 | 0.055 | -3 | 0.084 |
ULK2 |
0.533 | 0.305 | 2 | 0.747 |
NEK9 |
0.532 | 0.340 | 2 | 0.825 |
MAPKAPK5 |
0.528 | 0.069 | -3 | 0.126 |
NEK6 |
0.528 | 0.087 | -2 | 0.218 |
IKKB |
0.527 | 0.004 | -2 | 0.201 |
CDC7 |
0.527 | 0.056 | 1 | 0.721 |
MTOR |
0.526 | 0.066 | 1 | 0.658 |
GCN2 |
0.525 | 0.089 | 2 | 0.772 |
IKKA |
0.524 | 0.003 | -2 | 0.197 |
NDR2 |
0.524 | -0.028 | -3 | 0.068 |
CDK8 |
0.524 | 0.075 | 1 | 0.516 |
NEK7 |
0.523 | 0.100 | -3 | 0.176 |
PIM3 |
0.523 | -0.012 | -3 | 0.068 |
DSTYK |
0.523 | 0.050 | 2 | 0.822 |
NUAK2 |
0.523 | 0.035 | -3 | 0.111 |
NLK |
0.523 | 0.160 | 1 | 0.666 |
CDK19 |
0.522 | 0.067 | 1 | 0.483 |
PINK1 |
0.521 | 0.177 | 1 | 0.724 |
NEK2 |
0.520 | 0.207 | 2 | 0.818 |
CAMK2D |
0.520 | 0.042 | -3 | 0.116 |
PRKD3 |
0.520 | 0.014 | -3 | 0.078 |
LATS2 |
0.519 | -0.029 | -5 | 0.500 |
PIM1 |
0.519 | -0.004 | -3 | 0.059 |
PKN3 |
0.518 | 0.050 | -3 | 0.167 |
RSK3 |
0.517 | -0.014 | -3 | 0.079 |
CDKL5 |
0.517 | 0.016 | -3 | 0.088 |
SMG1 |
0.517 | 0.104 | 1 | 0.605 |
AURC |
0.516 | -0.021 | -2 | 0.100 |
PRPK |
0.516 | 0.028 | -1 | 0.152 |
PDHK4 |
0.516 | 0.021 | 1 | 0.694 |
P90RSK |
0.516 | -0.022 | -3 | 0.084 |
CDK9 |
0.516 | 0.067 | 1 | 0.520 |
CHK1 |
0.515 | 0.020 | -3 | 0.103 |
COT |
0.515 | -0.093 | 2 | 0.806 |
RAF1 |
0.514 | 0.010 | 1 | 0.677 |
NUAK1 |
0.514 | -0.010 | -3 | 0.098 |
PDHK1 |
0.513 | 0.019 | 1 | 0.656 |
SBK |
0.513 | 0.010 | -3 | 0.041 |
RSK2 |
0.513 | -0.040 | -3 | 0.056 |
IKKE |
0.513 | 0.023 | 1 | 0.562 |
HIPK4 |
0.513 | 0.015 | 1 | 0.630 |
WNK1 |
0.512 | 0.024 | -2 | 0.231 |
CK1E |
0.512 | -0.032 | -3 | 0.030 |
MLK2 |
0.511 | 0.097 | 2 | 0.805 |
PIM2 |
0.511 | 0.006 | -3 | 0.072 |
HUNK |
0.511 | 0.013 | 2 | 0.725 |
MOS |
0.510 | -0.040 | 1 | 0.760 |
NDR1 |
0.510 | -0.053 | -3 | 0.076 |
CDKL1 |
0.510 | -0.008 | -3 | 0.088 |
TBK1 |
0.509 | -0.002 | 1 | 0.576 |
MELK |
0.509 | -0.004 | -3 | 0.082 |
MLK3 |
0.509 | 0.078 | 2 | 0.777 |
P70S6K |
0.509 | -0.012 | -3 | 0.081 |
MSK2 |
0.509 | -0.040 | -3 | 0.067 |
TGFBR2 |
0.509 | -0.001 | -2 | 0.127 |
WNK3 |
0.509 | 0.049 | 1 | 0.652 |
P70S6KB |
0.508 | -0.041 | -3 | 0.078 |
CAMKK1 |
0.508 | 0.261 | -2 | 0.284 |
TSSK1 |
0.508 | -0.004 | -3 | 0.096 |
MLK1 |
0.508 | 0.033 | 2 | 0.822 |
CAMK1B |
0.508 | -0.050 | -3 | 0.101 |
GRK5 |
0.507 | -0.081 | -3 | 0.095 |
BCKDK |
0.507 | -0.044 | -1 | 0.114 |
CDK13 |
0.507 | 0.038 | 1 | 0.518 |
BMPR2 |
0.507 | 0.019 | -2 | 0.194 |
AURB |
0.507 | -0.022 | -2 | 0.092 |
PKACG |
0.507 | -0.052 | -2 | 0.132 |
CK1A |
0.507 | -0.026 | -3 | 0.013 |
DYRK2 |
0.507 | 0.025 | 1 | 0.560 |
ATR |
0.507 | -0.009 | 1 | 0.656 |
AKT2 |
0.506 | -0.017 | -3 | 0.057 |
PKACB |
0.506 | -0.049 | -2 | 0.112 |
PRKX |
0.506 | -0.056 | -3 | 0.030 |
CAMK2G |
0.506 | -0.032 | 2 | 0.703 |
PKN2 |
0.506 | -0.012 | -3 | 0.097 |
CAMK2A |
0.506 | -0.026 | 2 | 0.688 |
MASTL |
0.506 | 0.020 | -2 | 0.200 |
ERK1 |
0.506 | 0.048 | 1 | 0.517 |
CAMK4 |
0.505 | -0.043 | -3 | 0.103 |
CK1G1 |
0.505 | -0.032 | -3 | 0.020 |
TSSK2 |
0.505 | -0.019 | -5 | 0.500 |
MST4 |
0.505 | -0.002 | 2 | 0.874 |
CK1D |
0.505 | -0.040 | -3 | 0.028 |
MARK4 |
0.505 | -0.026 | 4 | 0.654 |
RSK4 |
0.505 | -0.044 | -3 | 0.059 |
TGFBR1 |
0.505 | 0.027 | -2 | 0.154 |
CLK1 |
0.504 | -0.000 | -3 | 0.071 |
ICK |
0.504 | -0.002 | -3 | 0.107 |
CAMKK2 |
0.504 | 0.208 | -2 | 0.284 |
NIK |
0.504 | -0.002 | -3 | 0.107 |
MNK2 |
0.504 | -0.021 | -2 | 0.177 |
AMPKA2 |
0.504 | -0.039 | -3 | 0.080 |
BRSK1 |
0.504 | -0.014 | -3 | 0.090 |
BMPR1B |
0.503 | 0.000 | 1 | 0.721 |
P38A |
0.503 | 0.064 | 1 | 0.597 |
SKMLCK |
0.503 | -0.044 | -2 | 0.224 |
SRPK1 |
0.503 | -0.033 | -3 | 0.056 |
AMPKA1 |
0.503 | -0.040 | -3 | 0.096 |
MSK1 |
0.503 | -0.042 | -3 | 0.070 |
PHKG1 |
0.503 | 0.020 | -3 | 0.076 |
CAMK2B |
0.503 | -0.020 | 2 | 0.668 |
DRAK1 |
0.502 | 0.041 | 1 | 0.700 |
CLK4 |
0.502 | -0.017 | -3 | 0.074 |
PKCB |
0.502 | 0.012 | 2 | 0.775 |
CDK7 |
0.502 | 0.006 | 1 | 0.542 |
CK1A2 |
0.502 | -0.040 | -3 | 0.026 |
CAMLCK |
0.502 | -0.019 | -2 | 0.200 |
DAPK2 |
0.502 | -0.015 | -3 | 0.111 |
SRPK2 |
0.502 | -0.038 | -3 | 0.056 |
GRK6 |
0.502 | -0.052 | 1 | 0.717 |
RIPK3 |
0.502 | -0.025 | 3 | 0.468 |
SGK3 |
0.502 | -0.019 | -3 | 0.064 |
CLK3 |
0.501 | -0.067 | 1 | 0.668 |
MYLK4 |
0.501 | -0.037 | -2 | 0.179 |
QIK |
0.501 | -0.027 | -3 | 0.113 |
GRK1 |
0.501 | -0.070 | -2 | 0.124 |
JNK3 |
0.501 | 0.049 | 1 | 0.521 |
ALK2 |
0.501 | 0.025 | -2 | 0.166 |
PKCA |
0.501 | 0.026 | 2 | 0.776 |
SIK |
0.501 | -0.037 | -3 | 0.086 |
PKCD |
0.501 | -0.008 | 2 | 0.800 |
PERK |
0.501 | 0.091 | -2 | 0.180 |
AKT3 |
0.500 | -0.017 | -3 | 0.039 |
NIM1 |
0.500 | -0.019 | 3 | 0.518 |
CDK12 |
0.500 | 0.029 | 1 | 0.484 |
PKACA |
0.500 | -0.048 | -2 | 0.099 |
ERK7 |
0.500 | 0.113 | 2 | 0.701 |
CAMK1A |
0.500 | -0.018 | -3 | 0.051 |
JNK2 |
0.500 | 0.055 | 1 | 0.478 |
AKT1 |
0.500 | -0.013 | -3 | 0.055 |
CHAK2 |
0.500 | -0.044 | -1 | 0.116 |
PKCG |
0.499 | -0.009 | 2 | 0.765 |
PKCZ |
0.499 | -0.001 | 2 | 0.795 |
PAK3 |
0.499 | -0.038 | -2 | 0.177 |
YSK4 |
0.499 | 0.031 | 1 | 0.620 |
NEK5 |
0.499 | 0.175 | 1 | 0.690 |
QSK |
0.498 | -0.035 | 4 | 0.633 |
RIPK1 |
0.498 | -0.011 | 1 | 0.666 |
AURA |
0.498 | -0.028 | -2 | 0.072 |
PAK1 |
0.498 | -0.051 | -2 | 0.157 |
ALK4 |
0.498 | 0.010 | -2 | 0.152 |
PLK1 |
0.498 | -0.008 | -2 | 0.133 |
WNK4 |
0.498 | 0.079 | -2 | 0.241 |
BRSK2 |
0.497 | -0.023 | -3 | 0.095 |
IRE1 |
0.497 | 0.005 | 1 | 0.659 |
ACVR2A |
0.497 | -0.021 | -2 | 0.127 |
PKR |
0.497 | 0.104 | 1 | 0.681 |
DLK |
0.497 | -0.045 | 1 | 0.676 |
SRPK3 |
0.497 | -0.034 | -3 | 0.069 |
P38B |
0.497 | 0.042 | 1 | 0.534 |
CAMK1D |
0.497 | -0.044 | -3 | 0.049 |
LKB1 |
0.497 | 0.159 | -3 | 0.182 |
HIPK2 |
0.497 | -0.002 | 1 | 0.487 |
CHAK1 |
0.497 | 0.038 | 2 | 0.730 |
MPSK1 |
0.497 | 0.111 | 1 | 0.774 |
CAMK1G |
0.496 | -0.042 | -3 | 0.107 |
BMPR1A |
0.496 | 0.012 | 1 | 0.682 |
HIPK1 |
0.496 | 0.005 | 1 | 0.581 |
DCAMKL1 |
0.496 | -0.025 | -3 | 0.074 |
HIPK3 |
0.496 | 0.029 | 1 | 0.555 |
ACVR2B |
0.496 | -0.026 | -2 | 0.144 |
SGK1 |
0.496 | -0.020 | -3 | 0.035 |
P38D |
0.496 | 0.054 | 1 | 0.436 |
CHK2 |
0.496 | -0.005 | -3 | 0.052 |
PKG2 |
0.496 | -0.048 | -2 | 0.105 |
PKCI |
0.495 | 0.034 | 2 | 0.790 |
ATM |
0.495 | -0.033 | 1 | 0.586 |
ERK2 |
0.495 | 0.030 | 1 | 0.545 |
PAK6 |
0.495 | -0.035 | -2 | 0.148 |
HRI |
0.495 | 0.052 | -2 | 0.191 |
GRK4 |
0.495 | -0.115 | -2 | 0.151 |
MARK3 |
0.495 | -0.023 | 4 | 0.590 |
MLK4 |
0.495 | 0.000 | 2 | 0.760 |
CDK18 |
0.495 | 0.004 | 1 | 0.501 |
DYRK3 |
0.495 | -0.000 | 1 | 0.570 |
DYRK1A |
0.495 | -0.006 | 1 | 0.568 |
MNK1 |
0.494 | -0.052 | -2 | 0.167 |
TTBK2 |
0.494 | -0.037 | 2 | 0.665 |
SNRK |
0.494 | -0.018 | 2 | 0.631 |
MARK2 |
0.494 | -0.012 | 4 | 0.567 |
MEK1 |
0.493 | 0.021 | 2 | 0.775 |
P38G |
0.493 | 0.026 | 1 | 0.436 |
CLK2 |
0.493 | -0.034 | -3 | 0.053 |
CDK5 |
0.493 | 0.018 | 1 | 0.571 |
DYRK1B |
0.493 | -0.003 | 1 | 0.527 |
ANKRD3 |
0.493 | -0.037 | 1 | 0.697 |
PKCH |
0.492 | -0.003 | 2 | 0.747 |
LATS1 |
0.492 | -0.066 | -3 | 0.073 |
MARK1 |
0.492 | -0.023 | 4 | 0.606 |
PKN1 |
0.492 | 0.007 | -3 | 0.085 |
MOK |
0.492 | 0.028 | 1 | 0.644 |
NEK3 |
0.492 | 0.221 | 1 | 0.578 |
TLK2 |
0.492 | -0.035 | 1 | 0.617 |
BIKE |
0.491 | 0.216 | 1 | 0.826 |
GRK3 |
0.491 | -0.055 | -2 | 0.100 |
KIS |
0.491 | -0.052 | 1 | 0.538 |
GRK2 |
0.491 | -0.057 | -2 | 0.125 |
PBK |
0.491 | 0.158 | 1 | 0.811 |
CDK10 |
0.491 | 0.013 | 1 | 0.524 |
BRAF |
0.491 | 0.049 | -4 | 0.500 |
PAK2 |
0.491 | -0.056 | -2 | 0.145 |
DYRK4 |
0.490 | 0.008 | 1 | 0.496 |
CDK14 |
0.490 | 0.023 | 1 | 0.536 |
PLK3 |
0.490 | -0.040 | 2 | 0.654 |
CK2A2 |
0.490 | -0.011 | 1 | 0.679 |
CDK17 |
0.489 | 0.007 | 1 | 0.449 |
PHKG2 |
0.489 | -0.013 | -3 | 0.093 |
CDK2 |
0.489 | -0.011 | 1 | 0.601 |
BUB1 |
0.489 | 0.043 | -5 | 0.500 |
JNK1 |
0.489 | 0.034 | 1 | 0.495 |
IRAK1 |
0.489 | 0.045 | -1 | 0.163 |
CDK1 |
0.488 | -0.017 | 1 | 0.521 |
GRK7 |
0.488 | -0.087 | 1 | 0.696 |
NEK4 |
0.488 | 0.177 | 1 | 0.609 |
MAK |
0.487 | 0.002 | -2 | 0.151 |
FAM20C |
0.487 | -0.039 | 2 | 0.466 |
PRP4 |
0.487 | -0.016 | -3 | 0.072 |
NEK8 |
0.487 | 0.105 | 2 | 0.804 |
VRK2 |
0.486 | 0.034 | 1 | 0.706 |
MEKK1 |
0.486 | 0.070 | 1 | 0.627 |
PAK5 |
0.485 | -0.044 | -2 | 0.109 |
PKCT |
0.485 | -0.019 | 2 | 0.755 |
IRAK4 |
0.485 | 0.043 | 1 | 0.639 |
DNAPK |
0.485 | -0.009 | 1 | 0.503 |
GAK |
0.484 | 0.126 | 1 | 0.844 |
NEK11 |
0.484 | 0.092 | 1 | 0.634 |
AAK1 |
0.484 | 0.197 | 1 | 0.771 |
SSTK |
0.483 | -0.034 | 4 | 0.629 |
CDK16 |
0.483 | -0.003 | 1 | 0.474 |
PKCE |
0.483 | -0.006 | 2 | 0.757 |
SMMLCK |
0.483 | -0.035 | -3 | 0.101 |
NEK1 |
0.482 | 0.199 | 1 | 0.648 |
CK1G3 |
0.482 | -0.037 | -3 | 0.008 |
PASK |
0.482 | -0.061 | -3 | 0.083 |
PKG1 |
0.481 | -0.043 | -2 | 0.078 |
IRE2 |
0.481 | -0.034 | 2 | 0.731 |
MRCKB |
0.481 | -0.030 | -3 | 0.066 |
CDK6 |
0.481 | 0.033 | 1 | 0.512 |
DAPK1 |
0.481 | -0.032 | -3 | 0.071 |
CDK3 |
0.480 | -0.006 | 1 | 0.475 |
CK2A1 |
0.479 | -0.020 | 1 | 0.659 |
TAK1 |
0.479 | 0.110 | 1 | 0.667 |
ZAK |
0.479 | -0.010 | 1 | 0.608 |
DCAMKL2 |
0.479 | -0.049 | -3 | 0.083 |
MRCKA |
0.479 | -0.044 | -3 | 0.065 |
MEK5 |
0.479 | -0.020 | 2 | 0.782 |
PAK4 |
0.479 | -0.046 | -2 | 0.105 |
TAO3 |
0.479 | -0.020 | 1 | 0.633 |
MEKK3 |
0.479 | -0.067 | 1 | 0.641 |
CRIK |
0.478 | -0.025 | -3 | 0.059 |
MEK2 |
0.478 | 0.115 | 2 | 0.754 |
LOK |
0.477 | 0.029 | -2 | 0.199 |
TLK1 |
0.477 | -0.082 | -2 | 0.192 |
MST3 |
0.477 | -0.001 | 2 | 0.842 |
CDK4 |
0.477 | 0.019 | 1 | 0.475 |
PLK4 |
0.476 | -0.047 | 2 | 0.564 |
DAPK3 |
0.476 | -0.048 | -3 | 0.072 |
MEKK2 |
0.476 | -0.002 | 2 | 0.777 |
PLK2 |
0.475 | -0.047 | -3 | 0.108 |
TTBK1 |
0.475 | -0.048 | 2 | 0.573 |
PDK1 |
0.474 | 0.024 | 1 | 0.651 |
ROCK2 |
0.473 | -0.031 | -3 | 0.065 |
RIPK2 |
0.473 | 0.011 | 1 | 0.560 |
LRRK2 |
0.473 | 0.044 | 2 | 0.817 |
TAO2 |
0.472 | 0.020 | 2 | 0.822 |
SLK |
0.471 | -0.037 | -2 | 0.142 |
STK33 |
0.471 | -0.010 | 2 | 0.583 |
HPK1 |
0.470 | 0.020 | 1 | 0.615 |
MST2 |
0.470 | -0.030 | 1 | 0.636 |
GSK3B |
0.470 | -0.017 | 4 | 0.378 |
MEKK6 |
0.470 | 0.038 | 1 | 0.645 |
ROCK1 |
0.470 | -0.027 | -3 | 0.064 |
HGK |
0.469 | 0.033 | 3 | 0.519 |
GCK |
0.469 | -0.009 | 1 | 0.643 |
MINK |
0.468 | 0.041 | 1 | 0.615 |
GSK3A |
0.467 | -0.035 | 4 | 0.388 |
TNIK |
0.466 | 0.022 | 3 | 0.529 |
YSK1 |
0.466 | 0.063 | 2 | 0.828 |
EEF2K |
0.466 | 0.003 | 3 | 0.499 |
MAP3K15 |
0.465 | 0.015 | 1 | 0.602 |
VRK1 |
0.463 | 0.024 | 2 | 0.755 |
DMPK1 |
0.463 | -0.049 | -3 | 0.056 |
KHS1 |
0.462 | 0.006 | 1 | 0.595 |
MYO3B |
0.461 | 0.093 | 2 | 0.826 |
KHS2 |
0.459 | -0.004 | 1 | 0.610 |
MST1 |
0.457 | -0.068 | 1 | 0.613 |
HASPIN |
0.456 | -0.029 | -1 | 0.096 |
CK1G2 |
0.453 | -0.076 | -3 | 0.018 |
TAO1 |
0.453 | 0.020 | 1 | 0.542 |
OSR1 |
0.452 | -0.038 | 2 | 0.816 |
MAP2K4_TYR |
0.450 | 0.032 | -1 | 0.162 |
MYO3A |
0.448 | 0.025 | 1 | 0.588 |
ASK1 |
0.446 | 0.006 | 1 | 0.597 |
PDHK3_TYR |
0.445 | -0.083 | 4 | 0.749 |
PDHK1_TYR |
0.444 | -0.057 | -1 | 0.126 |
ALPHAK3 |
0.443 | -0.077 | -1 | 0.121 |
MAP2K6_TYR |
0.443 | -0.072 | -1 | 0.140 |
TESK1_TYR |
0.442 | -0.072 | 3 | 0.588 |
PKMYT1_TYR |
0.442 | -0.038 | 3 | 0.569 |
LIMK2_TYR |
0.441 | -0.020 | -3 | 0.100 |
BMPR2_TYR |
0.439 | -0.081 | -1 | 0.120 |
TTK |
0.438 | -0.086 | -2 | 0.132 |
PDHK4_TYR |
0.438 | -0.129 | 2 | 0.785 |
YANK3 |
0.437 | -0.050 | 2 | 0.372 |
ABL2 |
0.437 | 0.002 | -1 | 0.147 |
MAP2K7_TYR |
0.437 | -0.157 | 2 | 0.769 |
ABL1 |
0.437 | 0.017 | -1 | 0.152 |
PINK1_TYR |
0.436 | -0.121 | 1 | 0.721 |
STLK3 |
0.436 | -0.046 | 1 | 0.558 |
LIMK1_TYR |
0.436 | -0.067 | 2 | 0.787 |
TXK |
0.435 | -0.010 | 1 | 0.738 |
HCK |
0.435 | 0.003 | -1 | 0.151 |
SRMS |
0.434 | -0.009 | 1 | 0.724 |
FER |
0.433 | -0.054 | 1 | 0.749 |
FGR |
0.433 | -0.045 | 1 | 0.790 |
YES1 |
0.432 | -0.029 | -1 | 0.152 |
NEK10_TYR |
0.432 | 0.014 | 1 | 0.555 |
TNK2 |
0.432 | 0.011 | 3 | 0.454 |
LCK |
0.430 | -0.016 | -1 | 0.127 |
BTK |
0.430 | 0.013 | -1 | 0.196 |
BLK |
0.430 | 0.000 | -1 | 0.139 |
EPHB4 |
0.429 | -0.077 | -1 | 0.124 |
EPHA6 |
0.429 | -0.070 | -1 | 0.113 |
TYK2 |
0.429 | -0.058 | 1 | 0.637 |
WEE1_TYR |
0.429 | -0.016 | -1 | 0.142 |
TYRO3 |
0.428 | -0.062 | 3 | 0.507 |
PTK6 |
0.427 | -0.057 | -1 | 0.123 |
EPHB3 |
0.427 | -0.059 | -1 | 0.129 |
ITK |
0.427 | -0.040 | -1 | 0.160 |
TEC |
0.426 | -0.028 | -1 | 0.168 |
FYN |
0.426 | -0.041 | -1 | 0.110 |
DDR1 |
0.425 | -0.114 | 4 | 0.672 |
MERTK |
0.425 | -0.048 | 3 | 0.505 |
RET |
0.425 | -0.140 | 1 | 0.639 |
ROS1 |
0.424 | -0.079 | 3 | 0.488 |
NTRK1 |
0.423 | -0.068 | -1 | 0.128 |
EPHB1 |
0.423 | -0.087 | 1 | 0.693 |
EPHB2 |
0.423 | -0.081 | -1 | 0.117 |
TNK1 |
0.422 | -0.045 | 3 | 0.512 |
JAK2 |
0.422 | -0.108 | 1 | 0.619 |
MST1R |
0.422 | -0.124 | 3 | 0.514 |
JAK1 |
0.422 | 0.005 | 1 | 0.572 |
LYN |
0.421 | -0.040 | 3 | 0.451 |
BMX |
0.421 | -0.060 | -1 | 0.132 |
EPHA4 |
0.421 | -0.079 | 2 | 0.658 |
AXL |
0.420 | -0.080 | 3 | 0.486 |
SRC |
0.420 | -0.047 | -1 | 0.118 |
NTRK2 |
0.419 | -0.079 | 3 | 0.482 |
CSF1R |
0.419 | -0.115 | 3 | 0.477 |
LTK |
0.418 | -0.066 | 3 | 0.463 |
INSRR |
0.418 | -0.136 | 3 | 0.463 |
TNNI3K_TYR |
0.417 | -0.056 | 1 | 0.606 |
YANK2 |
0.417 | -0.056 | 2 | 0.387 |
PDGFRA |
0.417 | -0.073 | 3 | 0.499 |
PTK2B |
0.417 | -0.056 | -1 | 0.136 |
TEK |
0.417 | -0.056 | 3 | 0.454 |
MATK |
0.416 | -0.085 | -1 | 0.119 |
NTRK3 |
0.416 | -0.101 | -1 | 0.108 |
MUSK |
0.416 | -0.022 | 1 | 0.608 |
PDGFRB |
0.415 | -0.114 | 3 | 0.494 |
EPHA1 |
0.415 | -0.062 | 3 | 0.461 |
FLT3 |
0.415 | -0.095 | 3 | 0.483 |
PTK2 |
0.415 | -0.050 | -1 | 0.083 |
EPHA3 |
0.414 | -0.088 | 2 | 0.641 |
SYK |
0.414 | -0.086 | -1 | 0.089 |
CSK |
0.414 | -0.081 | 2 | 0.676 |
KIT |
0.414 | -0.136 | 3 | 0.478 |
EPHA7 |
0.414 | -0.082 | 2 | 0.675 |
JAK3 |
0.413 | -0.165 | 1 | 0.643 |
FLT1 |
0.413 | -0.142 | -1 | 0.092 |
ALK |
0.413 | -0.094 | 3 | 0.436 |
FRK |
0.413 | -0.073 | -1 | 0.156 |
ERBB2 |
0.412 | -0.102 | 1 | 0.648 |
EPHA5 |
0.410 | -0.095 | 2 | 0.637 |
INSR |
0.409 | -0.103 | 3 | 0.462 |
FGFR1 |
0.409 | -0.136 | 3 | 0.478 |
FLT4 |
0.409 | -0.121 | 3 | 0.475 |
KDR |
0.408 | -0.154 | 3 | 0.439 |
MET |
0.408 | -0.151 | 3 | 0.488 |
EGFR |
0.408 | -0.079 | 1 | 0.583 |
EPHA8 |
0.407 | -0.103 | -1 | 0.100 |
FGFR2 |
0.407 | -0.185 | 3 | 0.488 |
FGFR4 |
0.403 | -0.108 | -1 | 0.112 |
FES |
0.402 | -0.068 | -1 | 0.122 |
FGFR3 |
0.402 | -0.168 | 3 | 0.463 |
EPHA2 |
0.401 | -0.106 | -1 | 0.095 |
IGF1R |
0.399 | -0.113 | 3 | 0.431 |
ZAP70 |
0.398 | -0.088 | -1 | 0.071 |
ERBB4 |
0.396 | -0.083 | 1 | 0.612 |
DDR2 |
0.395 | -0.152 | 3 | 0.419 |