Motif 1216 (n=59)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X1C1 | TMSB15C | S2 | ochoa | Thymosin beta 15C | None |
| A0A0A6YYG9 | ARPC4-TTLL3 | T2 | ochoa | Protein ARPC4-TTLL3 | None |
| B4DJY2 | TMEM233 | S2 | ochoa | Transmembrane protein 233 (Dispanin subfamily B member 2) (DSPB2) (Interferon-induced transmembrane domain-containing protein D2) | Probable accessory protein of voltage-gated sodium channels. {ECO:0000269|PubMed:37117223}. |
| O15247 | CLIC2 | S2 | ochoa | Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable) (PubMed:25581026). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253, ECO:0000269|PubMed:25581026, ECO:0000305|PubMed:15147738}. |
| O43791 | SPOP | S2 | ochoa | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}. |
| O95487 | SEC24B | S2 | ochoa | Protein transport protein Sec24B (SEC24-related protein B) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P08397 | HMBS | S2 | ochoa | Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18004775, PubMed:18936296, PubMed:19138865, PubMed:23815679). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled (PubMed:18936296). In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). {ECO:0000269|PubMed:18004775, ECO:0000269|PubMed:18936296, ECO:0000269|PubMed:19138865, ECO:0000269|PubMed:23815679}. |
| P08621 | SNRNP70 | T2 | ochoa | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}. |
| P0CG34 | TMSB15A | S2 | ochoa | Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8) | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250|UniProtKB:P62328}. |
| P0CG35 | TMSB15B | S2 | ochoa | Thymosin beta-15B | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration (PubMed:19296525). {ECO:0000250|UniProtKB:P62328, ECO:0000269|PubMed:19296525}. |
| P10412 | H1-4 | S2 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P11086 | PNMT | S2 | ochoa | Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) | Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity). {ECO:0000250|UniProtKB:P10937, ECO:0000269|PubMed:16277617, ECO:0000269|PubMed:16363801, ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}. |
| P16401 | H1-5 | S2 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S2 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S2 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P27448 | MARK3 | S2 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P35659 | DEK | S2 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P37198 | NUP62 | S2 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P49840 | GSK3A | S2 | ochoa | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). {ECO:0000250|UniProtKB:P18265, ECO:0000250|UniProtKB:P49841, ECO:0000250|UniProtKB:Q2NL51, ECO:0000269|PubMed:10868943, ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:11749387, ECO:0000303|PubMed:17478001, ECO:0000303|PubMed:19366350}. |
| P51532 | SMARCA4 | S2 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52566 | ARHGDIB | T2 | ochoa | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P56211 | ARPP19 | S2 | ochoa | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P59998 | ARPC4 | T2 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| P62306 | SNRPF | S2 | ochoa | Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}. |
| P62328 | TMSB4X | S2 | ochoa | Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)] | Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). {ECO:0000250|UniProtKB:P62326, ECO:0000269|PubMed:7694679}. |
| Q01130 | SRSF2 | S2 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q02539 | H1-1 | S2 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q07955 | SRSF1 | S2 | ochoa | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q08752 | PPID | S2 | ochoa | Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}. |
| Q12996 | CSTF3 | S2 | ochoa | Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. |
| Q13492 | PICALM | S2 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13829 | TNFAIP1 | S2 | ochoa | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}. |
| Q14353 | GAMT | S2 | ochoa | Guanidinoacetate N-methyltransferase (EC 2.1.1.2) | Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:24415674, PubMed:26003046, PubMed:26319512). Important in nervous system development (PubMed:24415674). {ECO:0000269|PubMed:24415674, ECO:0000269|PubMed:26003046, ECO:0000269|PubMed:26319512}. |
| Q15172 | PPP2R5A | S2 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q643R3 | LPCAT4 | S2 | ochoa | Lysophospholipid acyltransferase LPCAT4 (1-acylglycerol-3-phosphate O-acyltransferase 7) (1-AGP acyltransferase 7) (1-AGPAT 7) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (1-alkenylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.121) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 3) (Lysophosphatidylcholine acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase 2) (EC 2.3.1.n7) (Plasmalogen synthase) | Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}. |
| Q7L099 | RUFY3 | S2 | ochoa | Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) | ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:35314674}. |
| Q7Z4I7 | LIMS2 | T2 | ochoa | LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) | Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269|PubMed:12167643}. |
| Q7Z7F0 | KHDC4 | S2 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q8ND56 | LSM14A | S2 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q969X1 | TMBIM1 | S2 | ochoa | Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) | Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. |
| Q96FV9 | THOC1 | S2 | ochoa | THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96LT7 | C9orf72 | S2 | ochoa | Guanine nucleotide exchange factor C9orf72 | Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531, PubMed:37821429). Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy (PubMed:37821429). Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Promotes initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to CFL1/cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q6DFW0, ECO:0000269|PubMed:24549040, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27334615, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:27723745, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654, ECO:0000269|PubMed:37821429}.; FUNCTION: [Isoform 1]: Regulates stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}.; FUNCTION: [Isoform 2]: Does not play a role in regulation of stress granule assembly in response to cellular stress. {ECO:0000269|PubMed:27037575}. |
| Q9BRL6 | SRSF8 | S2 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BRT3 | MIEN1 | S2 | ochoa | Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35) | Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}. |
| Q9BZ29 | DOCK9 | S2 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9HD26 | GOPC | S2 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9UBC1 | NFKBIL1 | S2 | ochoa | NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) | Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. {ECO:0000269|PubMed:20829348}. |
| Q9UIU6 | SIX4 | S2 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UM13 | ANAPC10 | T2 | ochoa | Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UPR3 | SMG5 | S2 | ochoa | Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}. |
| P0C0S8 | H2AC11 | S2 | GPS6|SIGNOR|ELM|EPSD | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6FI13 | H2AC18 | S2 | GPS6|EPSD | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L7L0 | H2AC25 | S2 | GPS6|SIGNOR|iPTMNet|EPSD | Histone H2A type 3 (H2A-clustered histone 25) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8IUE6 | H2AC21 | S2 | GPS6|EPSD | Histone H2A type 2-B (H2A-clustered histone 21) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93077 | H2AC6 | S2 | GPS6|EPSD | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96KK5 | H2AC12 | S2 | GPS6|EPSD | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96QV6 | H2AC1 | S2 | GPS6|EPSD | Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99878 | H2AC14 | S2 | GPS6|EPSD | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62805 | H4C1 | S2 | EPSD | Histone H4 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3214858 | RMTs methylate histone arginines | 3.330669e-16 | 15.477 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.452172e-13 | 12.838 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.073408e-13 | 12.390 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.260769e-12 | 11.899 |
| R-HSA-3214847 | HATs acetylate histones | 3.294731e-11 | 10.482 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.299113e-10 | 9.276 |
| R-HSA-2559583 | Cellular Senescence | 5.900991e-10 | 9.229 |
| R-HSA-4839726 | Chromatin organization | 1.006604e-09 | 8.997 |
| R-HSA-9609690 | HCMV Early Events | 1.313571e-09 | 8.882 |
| R-HSA-5689603 | UCH proteinases | 2.405973e-09 | 8.619 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.941392e-09 | 8.531 |
| R-HSA-9610379 | HCMV Late Events | 2.783895e-09 | 8.555 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.665277e-09 | 8.176 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.110708e-08 | 7.954 |
| R-HSA-9609646 | HCMV Infection | 1.352780e-08 | 7.869 |
| R-HSA-5688426 | Deubiquitination | 1.859538e-07 | 6.731 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.209690e-07 | 6.656 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.910787e-07 | 6.536 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.910787e-07 | 6.536 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.488887e-07 | 6.457 |
| R-HSA-5334118 | DNA methylation | 3.881884e-07 | 6.411 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.146726e-07 | 6.382 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.146726e-07 | 6.382 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.903078e-07 | 6.310 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.801138e-07 | 6.236 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 6.584902e-07 | 6.181 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 8.402487e-07 | 6.076 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 8.402487e-07 | 6.076 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.059481e-06 | 5.975 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 9.844035e-07 | 6.007 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.058193e-06 | 5.975 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.148790e-07 | 6.039 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.184802e-06 | 5.926 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.184802e-06 | 5.926 |
| R-HSA-73927 | Depurination | 1.321528e-06 | 5.879 |
| R-HSA-68875 | Mitotic Prophase | 1.400242e-06 | 5.854 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.632173e-06 | 5.787 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.632173e-06 | 5.787 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.807651e-06 | 5.743 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.807651e-06 | 5.743 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.077912e-06 | 5.682 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.203036e-06 | 5.657 |
| R-HSA-73928 | Depyrimidination | 2.203036e-06 | 5.657 |
| R-HSA-9710421 | Defective pyroptosis | 2.424679e-06 | 5.615 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.920427e-06 | 5.535 |
| R-HSA-774815 | Nucleosome assembly | 2.920427e-06 | 5.535 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.196448e-06 | 5.495 |
| R-HSA-75153 | Apoptotic execution phase | 3.196448e-06 | 5.495 |
| R-HSA-912446 | Meiotic recombination | 4.899134e-06 | 5.310 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.479092e-06 | 5.349 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.311874e-06 | 5.275 |
| R-HSA-1221632 | Meiotic synapsis | 5.751392e-06 | 5.240 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.218914e-06 | 5.206 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.564667e-06 | 5.121 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.038555e-05 | 4.984 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.111617e-05 | 4.954 |
| R-HSA-211000 | Gene Silencing by RNA | 1.012264e-05 | 4.995 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.450466e-05 | 4.838 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.646960e-05 | 4.783 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.863608e-05 | 4.730 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.979933e-05 | 4.703 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.991756e-05 | 4.701 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.648982e-05 | 4.577 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.961027e-05 | 4.529 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.109881e-05 | 4.507 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.300891e-05 | 4.481 |
| R-HSA-977225 | Amyloid fiber formation | 3.481783e-05 | 4.458 |
| R-HSA-68886 | M Phase | 3.926158e-05 | 4.406 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.070924e-05 | 4.390 |
| R-HSA-1500620 | Meiosis | 4.283540e-05 | 4.368 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.221366e-05 | 4.282 |
| R-HSA-73884 | Base Excision Repair | 5.746064e-05 | 4.241 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.023225e-05 | 4.220 |
| R-HSA-69306 | DNA Replication | 7.551502e-05 | 4.122 |
| R-HSA-2262752 | Cellular responses to stress | 6.823558e-05 | 4.166 |
| R-HSA-157579 | Telomere Maintenance | 8.630321e-05 | 4.064 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.065312e-04 | 3.973 |
| R-HSA-72187 | mRNA 3'-end processing | 1.155240e-04 | 3.937 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.203043e-04 | 3.920 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.203043e-04 | 3.920 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.375951e-04 | 3.861 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.396757e-04 | 3.855 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.415233e-04 | 3.849 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.415233e-04 | 3.849 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.699279e-04 | 3.770 |
| R-HSA-9824446 | Viral Infection Pathways | 1.955666e-04 | 3.709 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.856968e-04 | 3.544 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.856968e-04 | 3.544 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.856968e-04 | 3.544 |
| R-HSA-73886 | Chromosome Maintenance | 2.419630e-04 | 3.616 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.860052e-04 | 3.544 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.587955e-04 | 3.587 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.593379e-04 | 3.586 |
| R-HSA-446728 | Cell junction organization | 2.226658e-04 | 3.652 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.297092e-04 | 3.639 |
| R-HSA-195721 | Signaling by WNT | 3.290789e-04 | 3.483 |
| R-HSA-1474165 | Reproduction | 3.458230e-04 | 3.461 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.598118e-04 | 3.444 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.275743e-04 | 3.369 |
| R-HSA-418990 | Adherens junctions interactions | 4.435371e-04 | 3.353 |
| R-HSA-1500931 | Cell-Cell communication | 4.567127e-04 | 3.340 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.159286e-04 | 3.287 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.272710e-04 | 3.278 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.335191e-04 | 3.273 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.412653e-04 | 3.193 |
| R-HSA-8939211 | ESR-mediated signaling | 6.619710e-04 | 3.179 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.233231e-04 | 3.141 |
| R-HSA-421270 | Cell-cell junction organization | 8.704400e-04 | 3.060 |
| R-HSA-109581 | Apoptosis | 8.854619e-04 | 3.053 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.473704e-03 | 2.832 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.852946e-03 | 2.732 |
| R-HSA-72172 | mRNA Splicing | 2.302901e-03 | 2.638 |
| R-HSA-5357801 | Programmed Cell Death | 2.347421e-03 | 2.629 |
| R-HSA-1640170 | Cell Cycle | 2.852648e-03 | 2.545 |
| R-HSA-5663205 | Infectious disease | 3.425272e-03 | 2.465 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.482923e-03 | 2.458 |
| R-HSA-157118 | Signaling by NOTCH | 4.336177e-03 | 2.363 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.862700e-03 | 2.313 |
| R-HSA-74160 | Gene expression (Transcription) | 5.733197e-03 | 2.242 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 6.878338e-03 | 2.163 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 6.878338e-03 | 2.163 |
| R-HSA-8953854 | Metabolism of RNA | 8.039725e-03 | 2.095 |
| R-HSA-5673000 | RAF activation | 1.248190e-02 | 1.904 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 1.191160e-02 | 1.924 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 1.306396e-02 | 1.884 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.745901e-02 | 1.758 |
| R-HSA-597592 | Post-translational protein modification | 1.773265e-02 | 1.751 |
| R-HSA-73894 | DNA Repair | 1.992051e-02 | 1.701 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.239091e-02 | 1.650 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.543743e-02 | 1.595 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.747679e-02 | 1.561 |
| R-HSA-1280218 | Adaptive Immune System | 2.959921e-02 | 1.529 |
| R-HSA-191859 | snRNP Assembly | 3.114690e-02 | 1.507 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.114690e-02 | 1.507 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.114690e-02 | 1.507 |
| R-HSA-1643685 | Disease | 3.575535e-02 | 1.447 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.822731e-02 | 1.418 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 4.016980e-02 | 1.396 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 4.409828e-02 | 1.356 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.487556e-02 | 1.348 |
| R-HSA-8852135 | Protein ubiquitination | 4.585805e-02 | 1.339 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 4.801092e-02 | 1.319 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.191709e-02 | 1.285 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 5.578895e-02 | 1.253 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 5.578895e-02 | 1.253 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 5.578895e-02 | 1.253 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 5.965446e-02 | 1.224 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 6.350439e-02 | 1.197 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 6.350439e-02 | 1.197 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 6.350439e-02 | 1.197 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 6.350439e-02 | 1.197 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 6.350439e-02 | 1.197 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 7.496126e-02 | 1.125 |
| R-HSA-176412 | Phosphorylation of the APC/C | 7.874946e-02 | 1.104 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 7.874946e-02 | 1.104 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 9.375006e-02 | 1.028 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 9.746247e-02 | 1.011 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.011599e-01 | 0.995 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 8.252238e-02 | 1.083 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 9.746247e-02 | 1.011 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.631533e-02 | 1.117 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 8.628008e-02 | 1.064 |
| R-HSA-4839744 | Signaling by APC mutants | 5.578895e-02 | 1.253 |
| R-HSA-4839735 | Signaling by AXIN mutants | 5.965446e-02 | 1.224 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 5.965446e-02 | 1.224 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 6.733879e-02 | 1.172 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 8.252238e-02 | 1.083 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 8.252238e-02 | 1.083 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 7.115773e-02 | 1.148 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 7.496126e-02 | 1.125 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 1.011599e-01 | 0.995 |
| R-HSA-68882 | Mitotic Anaphase | 7.301762e-02 | 1.137 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.374161e-02 | 1.132 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 7.115773e-02 | 1.148 |
| R-HSA-209905 | Catecholamine biosynthesis | 8.628008e-02 | 1.064 |
| R-HSA-71288 | Creatine metabolism | 9.746247e-02 | 1.011 |
| R-HSA-9635465 | Suppression of apoptosis | 5.578895e-02 | 1.253 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 6.350439e-02 | 1.197 |
| R-HSA-9683610 | Maturation of nucleoprotein | 6.733879e-02 | 1.172 |
| R-HSA-432142 | Platelet sensitization by LDL | 9.002262e-02 | 1.046 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 7.496126e-02 | 1.125 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 6.322849e-02 | 1.199 |
| R-HSA-9694631 | Maturation of nucleoprotein | 9.375006e-02 | 1.028 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.191690e-02 | 1.087 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.463624e-02 | 1.024 |
| R-HSA-5693538 | Homology Directed Repair | 1.022886e-01 | 0.990 |
| R-HSA-162582 | Signal Transduction | 1.069134e-01 | 0.971 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.371279e-02 | 1.196 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.500676e-02 | 1.187 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.824533e-02 | 1.235 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.482656e-02 | 1.188 |
| R-HSA-212436 | Generic Transcription Pathway | 1.069710e-01 | 0.971 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.121629e-01 | 0.950 |
| R-HSA-69481 | G2/M Checkpoints | 1.154047e-01 | 0.938 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.194244e-01 | 0.923 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.194244e-01 | 0.923 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 1.194244e-01 | 0.923 |
| R-HSA-3214842 | HDMs demethylate histones | 1.194244e-01 | 0.923 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.194244e-01 | 0.923 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.230332e-01 | 0.910 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.266275e-01 | 0.897 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.344348e-01 | 0.871 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.373233e-01 | 0.862 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.373233e-01 | 0.862 |
| R-HSA-1483257 | Phospholipid metabolism | 1.392119e-01 | 0.856 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.399975e-01 | 0.854 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.408599e-01 | 0.851 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.408599e-01 | 0.851 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.408599e-01 | 0.851 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.413961e-01 | 0.850 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.443821e-01 | 0.840 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.443821e-01 | 0.840 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.478902e-01 | 0.830 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.478902e-01 | 0.830 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.478902e-01 | 0.830 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.513841e-01 | 0.820 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.513841e-01 | 0.820 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.513841e-01 | 0.820 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 1.548638e-01 | 0.810 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.548638e-01 | 0.810 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.555436e-01 | 0.808 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.569735e-01 | 0.804 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.583295e-01 | 0.800 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.652190e-01 | 0.782 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.652190e-01 | 0.782 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.686429e-01 | 0.773 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.714065e-01 | 0.766 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.720530e-01 | 0.764 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.720530e-01 | 0.764 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.754492e-01 | 0.756 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.754492e-01 | 0.756 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.754492e-01 | 0.756 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.788318e-01 | 0.748 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.788318e-01 | 0.748 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.788318e-01 | 0.748 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.788318e-01 | 0.748 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.822007e-01 | 0.739 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.822007e-01 | 0.739 |
| R-HSA-189451 | Heme biosynthesis | 1.822007e-01 | 0.739 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.822007e-01 | 0.739 |
| R-HSA-392499 | Metabolism of proteins | 1.882842e-01 | 0.725 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.888977e-01 | 0.724 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.922259e-01 | 0.716 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.922259e-01 | 0.716 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.955407e-01 | 0.709 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.955407e-01 | 0.709 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.988420e-01 | 0.701 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.988420e-01 | 0.701 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.988420e-01 | 0.701 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.988420e-01 | 0.701 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.988420e-01 | 0.701 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.988420e-01 | 0.701 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.021301e-01 | 0.694 |
| R-HSA-1483191 | Synthesis of PC | 2.021301e-01 | 0.694 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.054048e-01 | 0.687 |
| R-HSA-9679506 | SARS-CoV Infections | 2.106675e-01 | 0.676 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.183719e-01 | 0.661 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.215809e-01 | 0.654 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.215809e-01 | 0.654 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.215809e-01 | 0.654 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.247770e-01 | 0.648 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.247770e-01 | 0.648 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.279602e-01 | 0.642 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.311305e-01 | 0.636 |
| R-HSA-5578775 | Ion homeostasis | 2.311305e-01 | 0.636 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 2.311305e-01 | 0.636 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.342880e-01 | 0.630 |
| R-HSA-1483166 | Synthesis of PA | 2.342880e-01 | 0.630 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.467907e-01 | 0.608 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.475561e-01 | 0.606 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.498848e-01 | 0.602 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.498848e-01 | 0.602 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.590922e-01 | 0.587 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.741913e-01 | 0.562 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.741913e-01 | 0.562 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.771745e-01 | 0.557 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.771745e-01 | 0.557 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.771745e-01 | 0.557 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.771745e-01 | 0.557 |
| R-HSA-189445 | Metabolism of porphyrins | 2.771745e-01 | 0.557 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.801457e-01 | 0.553 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.831048e-01 | 0.548 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.889872e-01 | 0.539 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.948220e-01 | 0.530 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.006097e-01 | 0.522 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.034859e-01 | 0.518 |
| R-HSA-9833482 | PKR-mediated signaling | 3.034859e-01 | 0.518 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.176934e-01 | 0.498 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.205005e-01 | 0.494 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.205005e-01 | 0.494 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.205005e-01 | 0.494 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.425512e-01 | 0.465 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.425512e-01 | 0.465 |
| R-HSA-168256 | Immune System | 3.545235e-01 | 0.450 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.621700e-01 | 0.441 |
| R-HSA-70171 | Glycolysis | 3.665166e-01 | 0.436 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.710237e-01 | 0.431 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.717243e-01 | 0.430 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.724949e-01 | 0.429 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.768898e-01 | 0.424 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.773212e-01 | 0.423 |
| R-HSA-418346 | Platelet homeostasis | 3.845597e-01 | 0.415 |
| R-HSA-69239 | Synthesis of DNA | 3.870956e-01 | 0.412 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.896212e-01 | 0.409 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.921366e-01 | 0.407 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.996216e-01 | 0.398 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.996216e-01 | 0.398 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.996216e-01 | 0.398 |
| R-HSA-70326 | Glucose metabolism | 4.167355e-01 | 0.380 |
| R-HSA-1266738 | Developmental Biology | 4.170999e-01 | 0.380 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.191408e-01 | 0.378 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.262982e-01 | 0.370 |
| R-HSA-3371556 | Cellular response to heat stress | 4.262982e-01 | 0.370 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.262982e-01 | 0.370 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.310214e-01 | 0.366 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.310214e-01 | 0.366 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.333687e-01 | 0.363 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.385523e-01 | 0.358 |
| R-HSA-114608 | Platelet degranulation | 4.426627e-01 | 0.354 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.455174e-01 | 0.351 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.495345e-01 | 0.347 |
| R-HSA-5576891 | Cardiac conduction | 4.540693e-01 | 0.343 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.585673e-01 | 0.339 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.718435e-01 | 0.326 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.761972e-01 | 0.322 |
| R-HSA-9664407 | Parasite infection | 4.761972e-01 | 0.322 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.761972e-01 | 0.322 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.783608e-01 | 0.320 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.826616e-01 | 0.316 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.932614e-01 | 0.307 |
| R-HSA-69242 | S Phase | 4.953556e-01 | 0.305 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.955505e-01 | 0.305 |
| R-HSA-913531 | Interferon Signaling | 4.955505e-01 | 0.305 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.995184e-01 | 0.301 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.097779e-01 | 0.293 |
| R-HSA-162587 | HIV Life Cycle | 5.138235e-01 | 0.289 |
| R-HSA-199991 | Membrane Trafficking | 5.204169e-01 | 0.284 |
| R-HSA-5619102 | SLC transporter disorders | 5.335633e-01 | 0.273 |
| R-HSA-72306 | tRNA processing | 5.412363e-01 | 0.267 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.487850e-01 | 0.261 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.506530e-01 | 0.259 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.506530e-01 | 0.259 |
| R-HSA-168255 | Influenza Infection | 5.580490e-01 | 0.253 |
| R-HSA-983712 | Ion channel transport | 5.760186e-01 | 0.240 |
| R-HSA-68877 | Mitotic Prometaphase | 5.830032e-01 | 0.234 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.983069e-01 | 0.223 |
| R-HSA-397014 | Muscle contraction | 6.162619e-01 | 0.210 |
| R-HSA-162906 | HIV Infection | 6.394780e-01 | 0.194 |
| R-HSA-109582 | Hemostasis | 6.471468e-01 | 0.189 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.669585e-01 | 0.176 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.682933e-01 | 0.175 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.036247e-01 | 0.153 |
| R-HSA-9658195 | Leishmania infection | 7.121624e-01 | 0.147 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.121624e-01 | 0.147 |
| R-HSA-9675108 | Nervous system development | 7.126432e-01 | 0.147 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.133622e-01 | 0.147 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 7.424982e-01 | 0.129 |
| R-HSA-8957322 | Metabolism of steroids | 7.595400e-01 | 0.119 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.184821e-01 | 0.087 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.348636e-01 | 0.078 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.413618e-01 | 0.075 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.619800e-01 | 0.065 |
| R-HSA-6798695 | Neutrophil degranulation | 8.631410e-01 | 0.064 |
| R-HSA-556833 | Metabolism of lipids | 8.769790e-01 | 0.057 |
| R-HSA-422475 | Axon guidance | 9.057276e-01 | 0.043 |
| R-HSA-449147 | Signaling by Interleukins | 9.329474e-01 | 0.030 |
| R-HSA-168249 | Innate Immune System | 9.782333e-01 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 9.855945e-01 | 0.006 |
| R-HSA-1430728 | Metabolism | 9.930827e-01 | 0.003 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.584 | 0.040 | -2 | 0.500 |
PIM3 |
0.584 | 0.091 | -3 | 0.500 |
PRKD2 |
0.582 | 0.053 | -3 | 0.500 |
CDKL5 |
0.581 | 0.085 | -3 | 0.500 |
ERK5 |
0.581 | 0.198 | 1 | 0.714 |
CDC7 |
0.581 | 0.112 | 1 | 0.707 |
PIM2 |
0.579 | 0.085 | -3 | 0.500 |
PIM1 |
0.579 | 0.071 | -3 | 0.500 |
PRKD1 |
0.578 | 0.065 | -3 | 0.500 |
MOS |
0.575 | 0.072 | 1 | 0.729 |
CLK3 |
0.574 | 0.005 | 1 | 0.635 |
NEK6 |
0.574 | 0.071 | -2 | 0.500 |
SMG1 |
0.574 | 0.158 | 1 | 0.618 |
MAPKAPK3 |
0.573 | 0.049 | -3 | 0.500 |
PKACB |
0.572 | 0.012 | -2 | 0.500 |
BMPR1B |
0.572 | 0.075 | 1 | 0.661 |
MAPKAPK2 |
0.572 | 0.026 | -3 | 0.500 |
CDKL1 |
0.571 | 0.051 | -3 | 0.500 |
MTOR |
0.571 | 0.044 | 1 | 0.525 |
DSTYK |
0.571 | 0.046 | 2 | 0.755 |
AKT2 |
0.571 | 0.031 | -3 | 0.500 |
COT |
0.570 | -0.005 | 2 | 0.686 |
PRKX |
0.570 | -0.008 | -3 | 0.500 |
RSK2 |
0.570 | 0.010 | -3 | 0.500 |
HIPK4 |
0.570 | 0.043 | 1 | 0.561 |
SRPK1 |
0.570 | 0.020 | -3 | 0.500 |
NDR2 |
0.570 | 0.010 | -3 | 0.500 |
RSK3 |
0.569 | 0.019 | -3 | 0.500 |
TGFBR2 |
0.569 | 0.059 | -2 | 0.500 |
PRKD3 |
0.569 | 0.024 | -3 | 0.500 |
MLK3 |
0.568 | 0.141 | 2 | 0.702 |
AKT3 |
0.568 | 0.047 | -3 | 0.500 |
IKKB |
0.568 | 0.028 | -2 | 0.500 |
SRPK2 |
0.568 | 0.002 | -3 | 0.500 |
AURB |
0.567 | 0.016 | -2 | 0.500 |
SBK |
0.566 | 0.032 | -3 | 0.500 |
NUAK2 |
0.566 | 0.021 | -3 | 0.500 |
GCN2 |
0.566 | 0.040 | 2 | 0.654 |
ATR |
0.566 | 0.039 | 1 | 0.648 |
MLK2 |
0.565 | 0.136 | 2 | 0.693 |
BMPR2 |
0.565 | 0.134 | -2 | 0.500 |
NDR1 |
0.565 | -0.011 | -3 | 0.500 |
PKACA |
0.564 | 0.004 | -2 | 0.500 |
NLK |
0.564 | 0.080 | 1 | 0.578 |
P90RSK |
0.563 | -0.001 | -3 | 0.500 |
PBK |
0.563 | 0.287 | 1 | 0.817 |
CDK19 |
0.563 | 0.051 | 1 | 0.427 |
PINK1 |
0.563 | 0.097 | 1 | 0.650 |
P70S6KB |
0.563 | -0.008 | -3 | 0.500 |
CK1D |
0.563 | -0.006 | -3 | 0.500 |
RAF1 |
0.562 | 0.007 | 1 | 0.581 |
MST4 |
0.562 | 0.021 | 2 | 0.805 |
PRPK |
0.562 | -0.037 | -1 | 0.124 |
SRPK3 |
0.562 | 0.014 | -3 | 0.500 |
BUB1 |
0.562 | 0.120 | -5 | 0.500 |
PDHK4 |
0.562 | -0.020 | 1 | 0.587 |
BMPR1A |
0.562 | 0.072 | 1 | 0.635 |
MLK1 |
0.562 | 0.078 | 2 | 0.730 |
ACVR2B |
0.561 | 0.046 | -2 | 0.500 |
LATS2 |
0.561 | -0.020 | -5 | 0.500 |
MAK |
0.561 | 0.059 | -2 | 0.500 |
CHK1 |
0.561 | 0.026 | -3 | 0.500 |
CLK4 |
0.561 | 0.006 | -3 | 0.500 |
ICK |
0.561 | 0.037 | -3 | 0.500 |
CLK1 |
0.561 | 0.007 | -3 | 0.500 |
GRK5 |
0.561 | -0.024 | -3 | 0.500 |
NEK7 |
0.560 | 0.006 | -3 | 0.500 |
AKT1 |
0.560 | 0.029 | -3 | 0.500 |
NEK9 |
0.560 | 0.112 | 2 | 0.701 |
CLK2 |
0.560 | -0.001 | -3 | 0.500 |
PKACG |
0.560 | -0.015 | -2 | 0.500 |
NIK |
0.560 | 0.049 | -3 | 0.500 |
PKCA |
0.560 | 0.072 | 2 | 0.696 |
CDK18 |
0.560 | 0.028 | 1 | 0.454 |
CK1E |
0.560 | -0.024 | -3 | 0.500 |
KIS |
0.559 | 0.017 | 1 | 0.493 |
PKCB |
0.559 | 0.049 | 2 | 0.690 |
CAMK2D |
0.559 | 0.020 | -3 | 0.500 |
CDK8 |
0.559 | 0.036 | 1 | 0.453 |
AURA |
0.559 | 0.005 | -2 | 0.500 |
PKCD |
0.559 | 0.045 | 2 | 0.699 |
IKKA |
0.559 | -0.007 | -2 | 0.500 |
DAPK2 |
0.559 | 0.018 | -3 | 0.500 |
PHKG1 |
0.559 | 0.057 | -3 | 0.500 |
PKG2 |
0.558 | 0.007 | -2 | 0.500 |
SKMLCK |
0.558 | -0.003 | -2 | 0.500 |
CHAK2 |
0.558 | -0.014 | -1 | 0.091 |
WNK1 |
0.558 | 0.013 | -2 | 0.500 |
RSK4 |
0.558 | -0.013 | -3 | 0.500 |
CDK10 |
0.558 | 0.048 | 1 | 0.464 |
NEK2 |
0.558 | 0.109 | 2 | 0.713 |
PKCG |
0.558 | 0.040 | 2 | 0.691 |
CAMK1B |
0.558 | -0.039 | -3 | 0.500 |
ACVR2A |
0.558 | 0.036 | -2 | 0.500 |
MAPKAPK5 |
0.557 | 0.028 | -3 | 0.500 |
CDK7 |
0.557 | 0.020 | 1 | 0.496 |
P38A |
0.557 | 0.071 | 1 | 0.548 |
ALK2 |
0.557 | 0.066 | -2 | 0.500 |
DYRK2 |
0.557 | 0.025 | 1 | 0.489 |
PKN2 |
0.557 | 0.002 | -3 | 0.500 |
MYLK4 |
0.556 | -0.001 | -2 | 0.500 |
MOK |
0.556 | 0.062 | 1 | 0.594 |
ULK2 |
0.556 | 0.005 | 2 | 0.609 |
CAMLCK |
0.556 | 0.018 | -2 | 0.500 |
ERK7 |
0.556 | 0.137 | 2 | 0.627 |
PDHK1 |
0.556 | -0.053 | 1 | 0.555 |
PKN3 |
0.556 | -0.002 | -3 | 0.500 |
PKCZ |
0.555 | 0.035 | 2 | 0.686 |
PAK6 |
0.555 | 0.010 | -2 | 0.500 |
TGFBR1 |
0.555 | 0.031 | -2 | 0.500 |
MSK1 |
0.555 | -0.013 | -3 | 0.500 |
PERK |
0.555 | 0.107 | -2 | 0.500 |
P70S6K |
0.555 | 0.001 | -3 | 0.500 |
CDK13 |
0.554 | 0.040 | 1 | 0.464 |
MNK2 |
0.554 | -0.013 | -2 | 0.500 |
P38D |
0.554 | 0.061 | 1 | 0.429 |
HIPK1 |
0.554 | 0.023 | 1 | 0.505 |
MELK |
0.554 | 0.002 | -3 | 0.500 |
CDK14 |
0.554 | 0.054 | 1 | 0.469 |
MASTL |
0.554 | 0.035 | -2 | 0.500 |
NUAK1 |
0.554 | -0.028 | -3 | 0.500 |
MSK2 |
0.554 | -0.030 | -3 | 0.500 |
ERK1 |
0.554 | 0.044 | 1 | 0.467 |
P38B |
0.553 | 0.060 | 1 | 0.486 |
LKB1 |
0.553 | 0.171 | -3 | 0.500 |
YSK4 |
0.553 | 0.056 | 1 | 0.500 |
MPSK1 |
0.553 | 0.146 | 1 | 0.716 |
ALK4 |
0.553 | 0.048 | -2 | 0.500 |
CAMK4 |
0.553 | -0.035 | -3 | 0.500 |
HIPK2 |
0.552 | 0.011 | 1 | 0.425 |
CK1A2 |
0.552 | -0.023 | -3 | 0.500 |
MRCKB |
0.551 | 0.023 | -3 | 0.500 |
CHK2 |
0.551 | 0.009 | -3 | 0.500 |
SGK3 |
0.551 | -0.001 | -3 | 0.500 |
PAK1 |
0.551 | -0.021 | -2 | 0.500 |
CDK9 |
0.551 | 0.047 | 1 | 0.463 |
DYRK3 |
0.550 | 0.013 | 1 | 0.491 |
PRP4 |
0.550 | 0.025 | -3 | 0.500 |
PKCI |
0.550 | 0.051 | 2 | 0.689 |
RIPK3 |
0.550 | -0.019 | 3 | 0.533 |
PAK3 |
0.550 | -0.010 | -2 | 0.500 |
IRE1 |
0.550 | 0.018 | 1 | 0.592 |
PKR |
0.550 | 0.085 | 1 | 0.615 |
SGK1 |
0.550 | 0.000 | -3 | 0.500 |
HIPK3 |
0.550 | 0.028 | 1 | 0.482 |
MNK1 |
0.549 | -0.033 | -2 | 0.500 |
AMPKA2 |
0.549 | -0.039 | -3 | 0.500 |
PKCE |
0.549 | 0.040 | 2 | 0.697 |
GRK1 |
0.549 | -0.067 | -2 | 0.500 |
CDK16 |
0.549 | 0.017 | 1 | 0.420 |
SIK |
0.549 | -0.048 | -3 | 0.500 |
BCKDK |
0.548 | -0.097 | -1 | 0.090 |
ATM |
0.548 | -0.015 | 1 | 0.607 |
LATS1 |
0.548 | -0.046 | -3 | 0.500 |
PKCH |
0.548 | 0.026 | 2 | 0.660 |
CAMK2A |
0.548 | -0.040 | 2 | 0.632 |
CDK1 |
0.548 | 0.001 | 1 | 0.452 |
AMPKA1 |
0.548 | -0.048 | -3 | 0.500 |
ANKRD3 |
0.548 | -0.011 | 1 | 0.597 |
QIK |
0.548 | -0.050 | -3 | 0.500 |
HRI |
0.548 | 0.037 | -2 | 0.500 |
MLK4 |
0.548 | 0.029 | 2 | 0.647 |
CDK5 |
0.548 | 0.019 | 1 | 0.531 |
CAMKK2 |
0.548 | 0.104 | -2 | 0.500 |
CDK12 |
0.547 | 0.031 | 1 | 0.424 |
WNK3 |
0.547 | -0.021 | 1 | 0.560 |
NEK5 |
0.547 | 0.122 | 1 | 0.621 |
CDK17 |
0.547 | 0.011 | 1 | 0.391 |
MARK4 |
0.546 | -0.081 | 4 | 0.515 |
PKN1 |
0.546 | 0.024 | -3 | 0.500 |
CAMK2G |
0.546 | -0.093 | 2 | 0.619 |
ULK1 |
0.546 | -0.041 | -3 | 0.500 |
QSK |
0.546 | -0.053 | 4 | 0.521 |
CAMKK1 |
0.546 | 0.076 | -2 | 0.500 |
GAK |
0.546 | 0.211 | 1 | 0.797 |
DRAK1 |
0.545 | 0.009 | 1 | 0.547 |
TBK1 |
0.545 | -0.044 | 1 | 0.443 |
TLK2 |
0.545 | -0.000 | 1 | 0.554 |
IKKE |
0.545 | -0.046 | 1 | 0.430 |
JNK2 |
0.545 | 0.042 | 1 | 0.415 |
CAMK1A |
0.545 | -0.016 | -3 | 0.500 |
DLK |
0.545 | -0.057 | 1 | 0.553 |
TSSK1 |
0.545 | -0.053 | -3 | 0.500 |
SLK |
0.545 | 0.053 | -2 | 0.500 |
DYRK1A |
0.545 | -0.001 | 1 | 0.504 |
BIKE |
0.545 | 0.273 | 1 | 0.813 |
CK1A |
0.544 | -0.029 | -3 | 0.500 |
PKCT |
0.544 | 0.017 | 2 | 0.653 |
PAK5 |
0.544 | -0.001 | -2 | 0.500 |
PAK2 |
0.544 | -0.017 | -2 | 0.500 |
CHAK1 |
0.544 | -0.021 | 2 | 0.649 |
IRE2 |
0.544 | 0.019 | 2 | 0.626 |
GRK6 |
0.544 | -0.073 | 1 | 0.608 |
PKG1 |
0.544 | 0.001 | -2 | 0.500 |
CAMK1D |
0.544 | -0.038 | -3 | 0.500 |
MST3 |
0.544 | 0.057 | 2 | 0.788 |
GRK2 |
0.543 | -0.044 | -2 | 0.500 |
CK1G1 |
0.543 | -0.034 | -3 | 0.500 |
CAMK2B |
0.543 | -0.040 | 2 | 0.586 |
GRK4 |
0.543 | -0.099 | -2 | 0.500 |
DAPK3 |
0.543 | -0.006 | -3 | 0.500 |
SMMLCK |
0.543 | -0.004 | -3 | 0.500 |
LOK |
0.543 | 0.098 | -2 | 0.500 |
MRCKA |
0.542 | -0.003 | -3 | 0.500 |
DYRK1B |
0.542 | -0.003 | 1 | 0.461 |
GRK7 |
0.542 | -0.066 | 1 | 0.576 |
NEK8 |
0.542 | 0.102 | 2 | 0.713 |
AAK1 |
0.542 | 0.263 | 1 | 0.789 |
ROCK2 |
0.542 | 0.018 | -3 | 0.500 |
HUNK |
0.542 | -0.097 | 2 | 0.612 |
RIPK1 |
0.541 | -0.055 | 1 | 0.555 |
GRK3 |
0.541 | -0.041 | -2 | 0.500 |
JNK3 |
0.541 | 0.021 | 1 | 0.452 |
TSSK2 |
0.541 | -0.081 | -5 | 0.500 |
DAPK1 |
0.541 | -0.007 | -3 | 0.500 |
ERK2 |
0.541 | 0.018 | 1 | 0.478 |
DYRK4 |
0.541 | 0.010 | 1 | 0.436 |
P38G |
0.541 | 0.018 | 1 | 0.378 |
DCAMKL1 |
0.540 | -0.044 | -3 | 0.500 |
CAMK1G |
0.540 | -0.064 | -3 | 0.500 |
NIM1 |
0.540 | -0.073 | 3 | 0.560 |
MEK1 |
0.540 | -0.028 | 2 | 0.650 |
DNAPK |
0.540 | 0.001 | 1 | 0.495 |
PHKG2 |
0.540 | -0.021 | -3 | 0.500 |
CRIK |
0.539 | 0.006 | -3 | 0.500 |
CDK6 |
0.538 | 0.046 | 1 | 0.459 |
TAO3 |
0.538 | 0.012 | 1 | 0.523 |
BRAF |
0.538 | 0.023 | -4 | 0.500 |
ROCK1 |
0.538 | 0.016 | -3 | 0.500 |
DMPK1 |
0.538 | 0.012 | -3 | 0.500 |
TAK1 |
0.538 | 0.140 | 1 | 0.572 |
PAK4 |
0.538 | -0.001 | -2 | 0.500 |
WNK4 |
0.537 | 0.030 | -2 | 0.500 |
HPK1 |
0.537 | 0.079 | 1 | 0.493 |
NEK3 |
0.537 | 0.131 | 1 | 0.488 |
PASK |
0.537 | -0.031 | -3 | 0.500 |
TTBK2 |
0.537 | -0.059 | 2 | 0.523 |
CDK2 |
0.536 | -0.022 | 1 | 0.505 |
FAM20C |
0.536 | -0.031 | 2 | 0.454 |
PLK1 |
0.536 | -0.062 | -2 | 0.500 |
CDK3 |
0.535 | -0.001 | 1 | 0.424 |
BRSK1 |
0.535 | -0.063 | -3 | 0.500 |
BRSK2 |
0.535 | -0.064 | -3 | 0.500 |
NEK4 |
0.535 | 0.104 | 1 | 0.530 |
GCK |
0.535 | 0.057 | 1 | 0.526 |
VRK2 |
0.535 | -0.046 | 1 | 0.622 |
TNIK |
0.535 | 0.089 | 3 | 0.657 |
SNRK |
0.534 | -0.055 | 2 | 0.529 |
TLK1 |
0.534 | -0.068 | -2 | 0.500 |
IRAK4 |
0.534 | 0.002 | 1 | 0.576 |
TAO2 |
0.534 | 0.058 | 2 | 0.733 |
MEKK1 |
0.533 | 0.015 | 1 | 0.533 |
MARK3 |
0.533 | -0.079 | 4 | 0.461 |
MST2 |
0.533 | 0.016 | 1 | 0.543 |
NEK11 |
0.533 | 0.041 | 1 | 0.492 |
HGK |
0.533 | 0.078 | 3 | 0.646 |
NEK1 |
0.533 | 0.142 | 1 | 0.564 |
MEKK6 |
0.533 | 0.054 | 1 | 0.565 |
MEK5 |
0.532 | -0.027 | 2 | 0.666 |
MEKK2 |
0.532 | 0.023 | 2 | 0.648 |
ZAK |
0.532 | -0.010 | 1 | 0.474 |
CDK4 |
0.532 | 0.027 | 1 | 0.419 |
MARK1 |
0.530 | -0.082 | 4 | 0.474 |
MYO3B |
0.530 | 0.136 | 2 | 0.748 |
MEKK3 |
0.529 | -0.080 | 1 | 0.525 |
MARK2 |
0.529 | -0.082 | 4 | 0.431 |
KHS2 |
0.529 | 0.062 | 1 | 0.499 |
CK2A2 |
0.528 | -0.042 | 1 | 0.648 |
MINK |
0.528 | 0.056 | 1 | 0.509 |
CK1G3 |
0.527 | -0.033 | -3 | 0.500 |
LRRK2 |
0.527 | 0.018 | 2 | 0.724 |
DCAMKL2 |
0.527 | -0.068 | -3 | 0.500 |
EEF2K |
0.526 | 0.033 | 3 | 0.585 |
PLK3 |
0.526 | -0.099 | 2 | 0.572 |
IRAK1 |
0.526 | -0.063 | -1 | 0.142 |
YSK1 |
0.526 | 0.076 | 2 | 0.728 |
KHS1 |
0.525 | 0.045 | 1 | 0.488 |
JNK1 |
0.524 | 0.004 | 1 | 0.421 |
PDK1 |
0.524 | 0.005 | 1 | 0.516 |
MST1 |
0.523 | -0.005 | 1 | 0.511 |
SSTK |
0.521 | -0.096 | 4 | 0.512 |
OSR1 |
0.521 | 0.026 | 2 | 0.669 |
PLK4 |
0.521 | -0.046 | 2 | 0.434 |
GSK3B |
0.520 | -0.042 | 4 | 0.209 |
CK2A1 |
0.520 | -0.047 | 1 | 0.620 |
MEK2 |
0.519 | -0.004 | 2 | 0.610 |
MAP3K15 |
0.518 | -0.031 | 1 | 0.473 |
TTBK1 |
0.518 | -0.075 | 2 | 0.446 |
GSK3A |
0.518 | -0.055 | 4 | 0.213 |
RIPK2 |
0.516 | -0.038 | 1 | 0.434 |
MYO3A |
0.515 | 0.063 | 1 | 0.486 |
TAO1 |
0.515 | 0.047 | 1 | 0.427 |
PLK2 |
0.514 | -0.082 | -3 | 0.500 |
STK33 |
0.514 | -0.057 | 2 | 0.475 |
HASPIN |
0.513 | -0.050 | -1 | 0.075 |
TTK |
0.512 | -0.007 | -2 | 0.500 |
VRK1 |
0.511 | -0.058 | 2 | 0.635 |
CK1G2 |
0.508 | -0.078 | -3 | 0.500 |
ALPHAK3 |
0.500 | -0.072 | -1 | 0.099 |
ASK1 |
0.496 | -0.047 | 1 | 0.458 |
YANK3 |
0.493 | -0.057 | 2 | 0.300 |
STLK3 |
0.489 | -0.061 | 1 | 0.445 |
MAP2K4_TYR |
0.482 | 0.157 | -1 | 0.136 |
TXK |
0.481 | 0.103 | 1 | 0.696 |
LCK |
0.478 | 0.095 | -1 | 0.105 |
YANK2 |
0.478 | -0.059 | 2 | 0.309 |
LIMK2_TYR |
0.478 | 0.079 | -3 | 0.500 |
BLK |
0.477 | 0.094 | -1 | 0.118 |
ABL1 |
0.477 | 0.076 | -1 | 0.130 |
ABL2 |
0.476 | 0.069 | -1 | 0.125 |
TESK1_TYR |
0.476 | 0.018 | 3 | 0.660 |
MAP2K6_TYR |
0.476 | 0.015 | -1 | 0.114 |
FGR |
0.475 | 0.064 | 1 | 0.733 |
PDHK3_TYR |
0.474 | -0.037 | 4 | 0.580 |
PDHK4_TYR |
0.472 | -0.047 | 2 | 0.724 |
TNK2 |
0.472 | 0.106 | 3 | 0.559 |
PDHK1_TYR |
0.472 | -0.046 | -1 | 0.103 |
PKMYT1_TYR |
0.470 | -0.029 | 3 | 0.637 |
HCK |
0.469 | 0.048 | -1 | 0.130 |
BMPR2_TYR |
0.469 | -0.068 | -1 | 0.097 |
EPHB4 |
0.468 | -0.009 | -1 | 0.103 |
LIMK1_TYR |
0.467 | -0.039 | 2 | 0.688 |
MAP2K7_TYR |
0.467 | -0.096 | 2 | 0.691 |
FER |
0.466 | -0.022 | 1 | 0.719 |
PINK1_TYR |
0.466 | -0.098 | 1 | 0.616 |
SRMS |
0.465 | 0.022 | 1 | 0.673 |
BTK |
0.465 | 0.042 | -1 | 0.178 |
EPHA6 |
0.465 | -0.048 | -1 | 0.090 |
YES1 |
0.465 | 0.024 | -1 | 0.131 |
ITK |
0.464 | 0.020 | -1 | 0.141 |
TEC |
0.463 | 0.006 | -1 | 0.151 |
FYN |
0.463 | 0.007 | -1 | 0.091 |
EPHB3 |
0.462 | -0.003 | -1 | 0.109 |
TYRO3 |
0.462 | -0.010 | 3 | 0.566 |
WEE1_TYR |
0.461 | -0.011 | -1 | 0.122 |
LYN |
0.461 | 0.015 | 3 | 0.496 |
PTK6 |
0.460 | -0.038 | -1 | 0.101 |
BMX |
0.460 | -0.024 | -1 | 0.116 |
EPHA4 |
0.458 | -0.042 | 2 | 0.609 |
EPHB2 |
0.458 | -0.047 | -1 | 0.098 |
RET |
0.457 | -0.104 | 1 | 0.534 |
MATK |
0.456 | -0.049 | -1 | 0.102 |
NEK10_TYR |
0.456 | -0.009 | 1 | 0.430 |
EPHB1 |
0.456 | -0.053 | 1 | 0.643 |
TNNI3K_TYR |
0.455 | -0.023 | 1 | 0.545 |
MERTK |
0.455 | -0.027 | 3 | 0.561 |
MST1R |
0.455 | -0.098 | 3 | 0.600 |
ROS1 |
0.454 | -0.071 | 3 | 0.545 |
TYK2 |
0.454 | -0.103 | 1 | 0.539 |
PTK2B |
0.454 | -0.025 | -1 | 0.113 |
SYK |
0.453 | -0.061 | -1 | 0.071 |
TNK1 |
0.453 | -0.031 | 3 | 0.568 |
SRC |
0.453 | -0.012 | -1 | 0.098 |
JAK2 |
0.452 | -0.110 | 1 | 0.522 |
EPHA1 |
0.451 | -0.030 | 3 | 0.554 |
JAK1 |
0.451 | -0.023 | 1 | 0.451 |
AXL |
0.450 | -0.049 | 3 | 0.549 |
FLT1 |
0.450 | -0.098 | -1 | 0.074 |
ZAP70 |
0.449 | -0.038 | -1 | 0.052 |
CSF1R |
0.449 | -0.112 | 3 | 0.575 |
DDR1 |
0.449 | -0.152 | 4 | 0.509 |
FRK |
0.449 | -0.054 | -1 | 0.135 |
PTK2 |
0.449 | -0.056 | -1 | 0.065 |
EPHA3 |
0.449 | -0.074 | 2 | 0.576 |
JAK3 |
0.448 | -0.156 | 1 | 0.524 |
EPHA7 |
0.448 | -0.060 | 2 | 0.600 |
TEK |
0.448 | -0.023 | 3 | 0.487 |
MET |
0.447 | -0.101 | 3 | 0.578 |
KDR |
0.447 | -0.099 | 3 | 0.538 |
LTK |
0.447 | -0.072 | 3 | 0.521 |
EPHA5 |
0.446 | -0.064 | 2 | 0.581 |
KIT |
0.445 | -0.127 | 3 | 0.565 |
FLT3 |
0.445 | -0.108 | 3 | 0.568 |
NTRK1 |
0.444 | -0.117 | -1 | 0.107 |
PDGFRB |
0.444 | -0.128 | 3 | 0.576 |
NTRK3 |
0.444 | -0.086 | -1 | 0.086 |
EPHA8 |
0.443 | -0.081 | -1 | 0.084 |
INSRR |
0.443 | -0.159 | 3 | 0.505 |
PDGFRA |
0.442 | -0.116 | 3 | 0.577 |
MUSK |
0.440 | -0.058 | 1 | 0.456 |
ALK |
0.440 | -0.115 | 3 | 0.490 |
NTRK2 |
0.439 | -0.114 | 3 | 0.519 |
ERBB2 |
0.438 | -0.116 | 1 | 0.505 |
FGFR2 |
0.438 | -0.179 | 3 | 0.563 |
CSK |
0.438 | -0.104 | 2 | 0.595 |
EPHA2 |
0.435 | -0.087 | -1 | 0.080 |
FGFR1 |
0.433 | -0.163 | 3 | 0.528 |
FLT4 |
0.433 | -0.156 | 3 | 0.526 |
FGFR3 |
0.432 | -0.161 | 3 | 0.526 |
EGFR |
0.431 | -0.111 | 1 | 0.427 |
FGFR4 |
0.430 | -0.110 | -1 | 0.093 |
INSR |
0.430 | -0.155 | 3 | 0.493 |
FES |
0.428 | -0.097 | -1 | 0.105 |
ERBB4 |
0.423 | -0.095 | 1 | 0.472 |
DDR2 |
0.422 | -0.167 | 3 | 0.498 |
IGF1R |
0.415 | -0.164 | 3 | 0.427 |