Motif 1215 (n=68)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0A6YYG9 ARPC4-TTLL3 T2 ochoa Protein ARPC4-TTLL3 None
A8CG34 POM121C S2 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
O00193 SMAP S2 ochoa Small acidic protein None
O60264 SMARCA5 S2 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O60664 PLIN3 S2 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O75431 MTX2 S2 ochoa Metaxin-2 (Mitochondrial outer membrane import complex protein 2) Involved in transport of proteins into the mitochondrion. {ECO:0000269|PubMed:10381257}.
O95777 LSM8 T2 ochoa U6 snRNA-associated Sm-like protein LSm8 Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.
P05412 JUN T2 psp Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}.
P08621 SNRNP70 T2 ochoa U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.
P10412 H1-4 S2 ochoa Histone H1.4 (Histone H1b) (Histone H1s-4) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16152 CBR1 S2 ochoa Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}.
P16401 H1-5 S2 ochoa Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16402 H1-3 S2 ochoa Histone H1.3 (Histone H1c) (Histone H1s-2) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403 H1-2 S2 ochoa Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16989 YBX3 S2 ochoa Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.
P18754 RCC1 S2 psp Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}.
P19532 TFE3 S2 ochoa Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.
P24844 MYL9 S2 psp Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}.
P28289 TMOD1 S2 psp Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}.
P30519 HMOX2 S2 ochoa Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form] [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}.
P35659 DEK S2 ochoa Protein DEK Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.
P43351 RAD52 S2 ochoa DNA repair protein RAD52 homolog Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:8702565}.
P46782 RPS5 T2 ochoa Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P46940 IQGAP1 S2 ochoa Ras GTPase-activating-like protein IQGAP1 (p195) Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.
P47712 PLA2G4A S2 ochoa Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}.
P51397 DAP S2 ochoa Death-associated protein 1 (DAP-1) Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}.
P51911 CNN1 S2 ochoa Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.
P52926 HMGA2 S2 ochoa High mobility group protein HMGI-C (High mobility group AT-hook protein 2) Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.
P56962 STX17 S2 psp Syntaxin-17 SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:28504273}.
P59998 ARPC4 T2 ochoa Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
P67809 YBX1 S2 ochoa Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}.
P67870 CSNK2B S2 ochoa|psp Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}.
P80217 IFI35 S2 ochoa Interferon-induced 35 kDa protein (IFP 35) (Ifi-35) Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}.
P98082 DAB2 S2 ochoa Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q02539 H1-1 S2 ochoa Histone H1.1 (Histone H1a) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q03169 TNFAIP2 S2 ochoa Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) May play a role as a mediator of inflammation and angiogenesis.
Q08752 PPID S2 ochoa Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}.
Q13393 PLD1 S2 psp Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}.
Q13542 EIF4EBP2 S2 ochoa Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}.
Q15172 PPP2R5A S2 ochoa Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q15573 TAF1A S2 ochoa TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}.
Q15717 ELAVL1 S2 ochoa ELAV-like protein 1 (Hu-antigen R) (HuR) RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}.
Q6ZN55 ZNF574 T2 ochoa Zinc finger protein 574 May be involved in transcriptional regulation.
Q7KZI7 MARK2 S2 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q86VP1 TAX1BP1 T2 ochoa Tax1-binding protein 1 (TRAF6-binding protein) Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.
Q8N9B5 JMY S2 ochoa Junction-mediating and -regulatory protein Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}.
Q8NA72 POC5 S2 ochoa Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}.
Q8NDC0 MAPK1IP1L S2 ochoa MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like) None
Q8WUD1 RAB2B T2 ochoa Ras-related protein Rab-2B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}.
Q92522 H1-10 S2 ochoa Histone H1.10 (Histone H1x) Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Q92609 TBC1D5 Y2 ochoa TBC1 domain family member 5 May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}.
Q96AJ9 VTI1A S2 ochoa Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}.
Q96HA1 POM121 S2 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96HR3 MED30 S2 ochoa Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}.
Q96P16 RPRD1A S2 ochoa Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q96SN7 ORAI2 S2 ochoa Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B) Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:17452328, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685}.
Q99439 CNN2 S2 ochoa Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Q99536 VAT1 S2 ochoa Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}.
Q9BY11 PACSIN1 S2 ochoa Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
Q9H773 DCTPP1 S2 ochoa dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.
Q9H8Y5 ANKZF1 S2 ochoa tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}.
Q9NQ86 TRIM36 S2 ochoa E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.
Q9NQG5 RPRD1B S2 ochoa Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q9NR55 BATF3 S2 ochoa Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (21 kDa small nuclear factor isolated from T-cells) (Jun dimerization protein p21SNFT) AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269|PubMed:10878360, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742}.
Q9NWU2 GID8 S2 ochoa Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). {ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}.
Q9NXR7 BABAM2 S2 ochoa BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:19261748, PubMed:21282113). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000305|PubMed:15465831}.
Q9UNF1 MAGED2 S2 ochoa Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.
Q9Y2V2 CARHSP1 S2 ochoa Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}.
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reactome_id name p -log10_p
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2.840775e-10 9.547
R-HSA-140342 Apoptosis induced DNA fragmentation 6.039852e-09 8.219
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.932503e-08 7.307
R-HSA-2559583 Cellular Senescence 4.857405e-06 5.314
R-HSA-75153 Apoptotic execution phase 6.426459e-06 5.192
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 2.125393e-04 3.673
R-HSA-109581 Apoptosis 2.184409e-04 3.661
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.608761e-04 3.251
R-HSA-5357801 Programmed Cell Death 7.053934e-04 3.152
R-HSA-180746 Nuclear import of Rev protein 1.009879e-03 2.996
R-HSA-2262752 Cellular responses to stress 1.097460e-03 2.960
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.317332e-03 2.880
R-HSA-177243 Interactions of Rev with host cellular proteins 1.490812e-03 2.827
R-HSA-8953897 Cellular responses to stimuli 3.046888e-03 2.516
R-HSA-1483166 Synthesis of PA 3.711620e-03 2.430
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 4.037668e-03 2.394
R-HSA-1483148 Synthesis of PG 4.545990e-03 2.342
R-HSA-5693606 DNA Double Strand Break Response 5.513563e-03 2.259
R-HSA-432142 Platelet sensitization by LDL 5.420064e-03 2.266
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.717858e-03 2.243
R-HSA-427413 NoRC negatively regulates rRNA expression 6.357814e-03 2.197
R-HSA-5578749 Transcriptional regulation by small RNAs 6.580241e-03 2.182
R-HSA-5602566 TICAM1 deficiency - HSE 9.395406e-03 2.027
R-HSA-5602571 TRAF3 deficiency - HSE 1.406039e-02 1.852
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 2.792565e-02 1.554
R-HSA-9017802 Noncanonical activation of NOTCH3 3.706207e-02 1.431
R-HSA-2562578 TRIF-mediated programmed cell death 4.611374e-02 1.336
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 5.060803e-02 1.296
R-HSA-111995 phospho-PLA2 pathway 5.060803e-02 1.296
R-HSA-196025 Formation of annular gap junctions 5.060803e-02 1.296
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 5.508143e-02 1.259
R-HSA-9613354 Lipophagy 5.508143e-02 1.259
R-HSA-190873 Gap junction degradation 5.508143e-02 1.259
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 5.953402e-02 1.225
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 6.396591e-02 1.194
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 6.396591e-02 1.194
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 6.396591e-02 1.194
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 6.837719e-02 1.165
R-HSA-5339716 Signaling by GSK3beta mutants 6.837719e-02 1.165
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 7.276795e-02 1.138
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 7.276795e-02 1.138
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 7.276795e-02 1.138
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 7.276795e-02 1.138
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 7.276795e-02 1.138
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.276530e-02 1.894
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.344361e-02 1.871
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.344361e-02 1.871
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 8.581807e-02 1.066
R-HSA-196299 Beta-catenin phosphorylation cascade 8.581807e-02 1.066
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 8.581807e-02 1.066
R-HSA-1855170 IPs transport between nucleus and cytosol 1.484619e-02 1.828
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.484619e-02 1.828
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.557017e-02 1.808
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 1.706272e-02 1.768
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 2.022198e-02 1.694
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.104721e-02 1.677
R-HSA-937041 IKK complex recruitment mediated by RIP1 1.071666e-01 0.970
R-HSA-73772 RNA Polymerase I Promoter Escape 3.298555e-02 1.482
R-HSA-171306 Packaging Of Telomere Ends 1.443614e-01 0.841
R-HSA-5334118 DNA methylation 1.524169e-01 0.817
R-HSA-9615710 Late endosomal microautophagy 1.524169e-01 0.817
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.683040e-01 0.774
R-HSA-390522 Striated Muscle Contraction 1.722297e-01 0.764
R-HSA-72172 mRNA Splicing 8.982660e-02 1.047
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.786304e-02 1.168
R-HSA-72163 mRNA Splicing - Major Pathway 8.004347e-02 1.097
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 1.417716e-01 0.848
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 1.417716e-01 0.848
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 6.837719e-02 1.165
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 9.441728e-02 1.025
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 1.417716e-01 0.848
R-HSA-427359 SIRT1 negatively regulates rRNA expression 1.861373e-02 1.730
R-HSA-389513 Co-inhibition by CTLA4 1.113769e-01 0.953
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.373226e-02 1.862
R-HSA-6798695 Neutrophil degranulation 2.558274e-02 1.592
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 8.526917e-03 2.069
R-HSA-73863 RNA Polymerase I Transcription Termination 1.443614e-01 0.841
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.645923e-02 1.248
R-HSA-5619507 Activation of HOX genes during differentiation 1.044062e-01 0.981
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 1.044062e-01 0.981
R-HSA-73864 RNA Polymerase I Transcription 6.270516e-02 1.203
R-HSA-73854 RNA Polymerase I Promoter Clearance 6.017927e-02 1.221
R-HSA-212165 Epigenetic regulation of gene expression 2.329234e-02 1.633
R-HSA-450341 Activation of the AP-1 family of transcription factors 5.508143e-02 1.259
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 7.450042e-02 1.128
R-HSA-4839744 Signaling by APC mutants 6.396591e-02 1.194
R-HSA-4839748 Signaling by AMER1 mutants 6.837719e-02 1.165
R-HSA-4839735 Signaling by AXIN mutants 6.837719e-02 1.165
R-HSA-180910 Vpr-mediated nuclear import of PICs 1.861373e-02 1.730
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 2.628482e-02 1.580
R-HSA-774815 Nucleosome assembly 2.628482e-02 1.580
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 2.628482e-02 1.580
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 2.813631e-02 1.551
R-HSA-8949613 Cristae formation 1.443614e-01 0.841
R-HSA-73728 RNA Polymerase I Promoter Opening 1.443614e-01 0.841
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 1.524169e-01 0.817
R-HSA-4791275 Signaling by WNT in cancer 1.643600e-01 0.784
R-HSA-8856828 Clathrin-mediated endocytosis 4.098260e-02 1.387
R-HSA-9613829 Chaperone Mediated Autophagy 1.029367e-01 0.987
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.811610e-02 1.318
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.029367e-01 0.987
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.020907e-02 1.991
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 1.557017e-02 1.808
R-HSA-139853 Elevation of cytosolic Ca2+ levels 9.868690e-02 1.006
R-HSA-9948299 Ribosome-associated quality control 1.663777e-01 0.779
R-HSA-166166 MyD88-independent TLR4 cascade 1.134707e-01 0.945
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1.059026e-01 0.975
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.134707e-01 0.945
R-HSA-5693532 DNA Double-Strand Break Repair 8.899015e-03 2.051
R-HSA-9706019 RHOBTB3 ATPase cycle 6.396591e-02 1.194
R-HSA-1483115 Hydrolysis of LPC 8.148829e-02 1.089
R-HSA-5689901 Metalloprotease DUBs 1.403054e-01 0.853
R-HSA-194441 Metabolism of non-coding RNA 4.027746e-02 1.395
R-HSA-191859 snRNP Assembly 4.027746e-02 1.395
R-HSA-168325 Viral Messenger RNA Synthesis 4.246317e-02 1.372
R-HSA-9609690 HCMV Early Events 8.178554e-02 1.087
R-HSA-445355 Smooth Muscle Contraction 3.399212e-02 1.469
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 2.908123e-02 1.536
R-HSA-68875 Mitotic Prophase 2.583242e-02 1.588
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.023972e-02 1.694
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1.443614e-01 0.841
R-HSA-168273 Influenza Viral RNA Transcription and Replication 4.887883e-02 1.311
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 6.786304e-02 1.168
R-HSA-3214847 HATs acetylate histones 9.555638e-02 1.020
R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 3.250450e-02 1.488
R-HSA-201688 WNT mediated activation of DVL 5.508143e-02 1.259
R-HSA-2514853 Condensation of Prometaphase Chromosomes 6.837719e-02 1.165
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 7.276795e-02 1.138
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 8.581807e-02 1.066
R-HSA-176033 Interactions of Vpr with host cellular proteins 2.104721e-02 1.677
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 2.188631e-02 1.660
R-HSA-1482801 Acyl chain remodelling of PS 1.362303e-01 0.866
R-HSA-3928663 EPHA-mediated growth cone collapse 1.443614e-01 0.841
R-HSA-418360 Platelet calcium homeostasis 1.524169e-01 0.817
R-HSA-68886 M Phase 1.208854e-02 1.918
R-HSA-2559580 Oxidative Stress Induced Senescence 9.995327e-02 1.000
R-HSA-1482788 Acyl chain remodelling of PC 1.722297e-01 0.764
R-HSA-9018519 Estrogen-dependent gene expression 1.630528e-01 0.788
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 8.148829e-02 1.089
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 2.720412e-02 1.565
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 1.643600e-01 0.784
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 1.683040e-01 0.774
R-HSA-8953854 Metabolism of RNA 1.091400e-01 0.962
R-HSA-8878171 Transcriptional regulation by RUNX1 2.933269e-02 1.533
R-HSA-9609646 HCMV Infection 1.356038e-01 0.868
R-HSA-8939211 ESR-mediated signaling 3.363251e-02 1.473
R-HSA-397014 Muscle contraction 2.436175e-02 1.613
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 1.524169e-01 0.817
R-HSA-68882 Mitotic Anaphase 1.010429e-01 0.995
R-HSA-73886 Chromosome Maintenance 1.337601e-01 0.874
R-HSA-68616 Assembly of the ORC complex at the origin of replication 1.683040e-01 0.774
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.020022e-01 0.991
R-HSA-199991 Membrane Trafficking 1.359090e-02 1.867
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.205367e-02 1.657
R-HSA-168276 NS1 Mediated Effects on Host Pathways 2.022198e-02 1.694
R-HSA-1482922 Acyl chain remodelling of PI 1.113769e-01 0.953
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 1.280231e-01 0.893
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 1.321363e-01 0.879
R-HSA-69473 G2/M DNA damage checkpoint 5.768992e-02 1.239
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 6.526671e-02 1.185
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 6.356110e-02 1.197
R-HSA-8856688 Golgi-to-ER retrograde transport 1.547967e-01 0.810
R-HSA-388841 Regulation of T cell activation by CD28 family 4.188692e-02 1.378
R-HSA-5693538 Homology Directed Repair 2.485709e-02 1.605
R-HSA-9909648 Regulation of PD-L1(CD274) expression 6.200976e-02 1.208
R-HSA-5653656 Vesicle-mediated transport 4.160613e-02 1.381
R-HSA-2980766 Nuclear Envelope Breakdown 3.813637e-02 1.419
R-HSA-389948 Co-inhibition by PD-1 8.531896e-02 1.069
R-HSA-8934903 Receptor Mediated Mitophagy 5.953402e-02 1.225
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.113769e-01 0.953
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 1.321363e-01 0.879
R-HSA-6784531 tRNA processing in the nucleus 4.357244e-02 1.361
R-HSA-73894 DNA Repair 1.053361e-01 0.977
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 1.238906e-01 0.907
R-HSA-418346 Platelet homeostasis 1.860172e-02 1.730
R-HSA-1483249 Inositol phosphate metabolism 1.165367e-01 0.934
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 7.713829e-02 1.113
R-HSA-1483206 Glycerophospholipid biosynthesis 2.114936e-02 1.675
R-HSA-168255 Influenza Infection 6.751800e-02 1.171
R-HSA-5693607 Processing of DNA double-strand break ends 6.656058e-02 1.177
R-HSA-74160 Gene expression (Transcription) 4.390212e-02 1.358
R-HSA-9006931 Signaling by Nuclear Receptors 1.075983e-01 0.968
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 9.012770e-02 1.045
R-HSA-9664420 Killing mechanisms 9.012770e-02 1.045
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 9.012770e-02 1.045
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.357244e-02 1.361
R-HSA-162909 Host Interactions of HIV factors 2.784429e-02 1.555
R-HSA-1912408 Pre-NOTCH Transcription and Translation 8.133676e-02 1.090
R-HSA-9663891 Selective autophagy 7.721180e-02 1.112
R-HSA-1482925 Acyl chain remodelling of PG 1.155676e-01 0.937
R-HSA-168249 Innate Immune System 5.178580e-02 1.286
R-HSA-69620 Cell Cycle Checkpoints 1.442701e-01 0.841
R-HSA-1640170 Cell Cycle 2.159438e-02 1.666
R-HSA-3928664 Ephrin signaling 1.029367e-01 0.987
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.029367e-01 0.987
R-HSA-445144 Signal transduction by L1 1.113769e-01 0.953
R-HSA-70171 Glycolysis 9.701563e-02 1.013
R-HSA-1912422 Pre-NOTCH Expression and Processing 1.180777e-01 0.928
R-HSA-1482798 Acyl chain remodeling of CL 8.148829e-02 1.089
R-HSA-2029485 Role of phospholipids in phagocytosis 1.242927e-01 0.906
R-HSA-69481 G2/M Checkpoints 1.450051e-01 0.839
R-HSA-909733 Interferon alpha/beta signaling 1.242927e-01 0.906
R-HSA-373753 Nephrin family interactions 1.113769e-01 0.953
R-HSA-400685 Sema4D in semaphorin signaling 1.362303e-01 0.866
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 1.603976e-01 0.795
R-HSA-1483257 Phospholipid metabolism 6.212447e-02 1.207
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 1.722297e-01 0.764
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 9.995327e-02 1.000
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.104265e-01 0.957
R-HSA-69278 Cell Cycle, Mitotic 5.903436e-02 1.229
R-HSA-1169408 ISG15 antiviral mechanism 5.892997e-02 1.230
R-HSA-1632852 Macroautophagy 1.713876e-01 0.766
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 1.403054e-01 0.853
R-HSA-168256 Immune System 8.535733e-03 2.069
R-HSA-201681 TCF dependent signaling in response to WNT 7.076324e-02 1.150
R-HSA-9645723 Diseases of programmed cell death 7.721180e-02 1.112
R-HSA-2682334 EPH-Ephrin signaling 1.267187e-02 1.897
R-HSA-6807070 PTEN Regulation 1.680448e-01 0.775
R-HSA-975155 MyD88 dependent cascade initiated on endosome 1.119459e-01 0.951
R-HSA-9828806 Maturation of hRSV A proteins 1.443614e-01 0.841
R-HSA-211000 Gene Silencing by RNA 1.901536e-02 1.721
R-HSA-70326 Glucose metabolism 1.274298e-01 0.895
R-HSA-913531 Interferon Signaling 1.222473e-02 1.913
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.180777e-01 0.928
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 1.227314e-01 0.911
R-HSA-8863678 Neurodegenerative Diseases 1.321363e-01 0.879
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.321363e-01 0.879
R-HSA-189483 Heme degradation 1.722297e-01 0.764
R-HSA-9705683 SARS-CoV-2-host interactions 1.127932e-01 0.948
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 1.443614e-01 0.841
R-HSA-162599 Late Phase of HIV Life Cycle 4.035638e-02 1.394
R-HSA-162906 HIV Infection 1.117945e-01 0.952
R-HSA-157118 Signaling by NOTCH 1.250419e-01 0.903
R-HSA-3371556 Cellular response to heat stress 1.337601e-01 0.874
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 1.647137e-01 0.783
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.819416e-02 1.317
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 4.696445e-02 1.328
R-HSA-162587 HIV Life Cycle 5.026256e-02 1.299
R-HSA-422475 Axon guidance 1.293241e-01 0.888
R-HSA-9675108 Nervous system development 1.560011e-01 0.807
R-HSA-9020591 Interleukin-12 signaling 6.017927e-02 1.221
R-HSA-1280215 Cytokine Signaling in Immune system 7.245226e-02 1.140
R-HSA-447115 Interleukin-12 family signaling 7.585218e-02 1.120
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.747417e-01 0.758
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 1.761370e-01 0.754
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 1.761370e-01 0.754
R-HSA-5673000 RAF activation 1.761370e-01 0.754
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1.761370e-01 0.754
R-HSA-392518 Signal amplification 1.761370e-01 0.754
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 1.761370e-01 0.754
R-HSA-5205647 Mitophagy 1.761370e-01 0.754
R-HSA-1482839 Acyl chain remodelling of PE 1.800262e-01 0.745
R-HSA-73857 RNA Polymerase II Transcription 1.823475e-01 0.739
R-HSA-212300 PRC2 methylates histones and DNA 1.838972e-01 0.735
R-HSA-163560 Triglyceride catabolism 1.838972e-01 0.735
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.848671e-01 0.733
R-HSA-1257604 PIP3 activates AKT signaling 1.865330e-01 0.729
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.877502e-01 0.726
R-HSA-110331 Cleavage of the damaged purine 1.877502e-01 0.726
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.877502e-01 0.726
R-HSA-195721 Signaling by WNT 1.900967e-01 0.721
R-HSA-73927 Depurination 1.915853e-01 0.718
R-HSA-2142753 Arachidonate metabolism 1.916649e-01 0.717
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 1.950767e-01 0.710
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 1.954025e-01 0.709
R-HSA-9612973 Autophagy 1.984965e-01 0.702
R-HSA-9670095 Inhibition of DNA recombination at telomere 1.992019e-01 0.701
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 1.992019e-01 0.701
R-HSA-5602358 Diseases associated with the TLR signaling cascade 1.992019e-01 0.701
R-HSA-5260271 Diseases of Immune System 1.992019e-01 0.701
R-HSA-9610379 HCMV Late Events 2.002093e-01 0.699
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 2.029835e-01 0.693
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 2.029835e-01 0.693
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 2.029835e-01 0.693
R-HSA-5633007 Regulation of TP53 Activity 2.053583e-01 0.687
R-HSA-5674135 MAP2K and MAPK activation 2.067476e-01 0.685
R-HSA-9656223 Signaling by RAF1 mutants 2.067476e-01 0.685
R-HSA-6811438 Intra-Golgi traffic 2.067476e-01 0.685
R-HSA-5675221 Negative regulation of MAPK pathway 2.067476e-01 0.685
R-HSA-73762 RNA Polymerase I Transcription Initiation 2.104941e-01 0.677
R-HSA-111996 Ca-dependent events 2.104941e-01 0.677
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 2.104941e-01 0.677
R-HSA-110329 Cleavage of the damaged pyrimidine 2.104941e-01 0.677
R-HSA-73928 Depyrimidination 2.104941e-01 0.677
R-HSA-1500931 Cell-Cell communication 2.118339e-01 0.674
R-HSA-9710421 Defective pyroptosis 2.142232e-01 0.669
R-HSA-5619102 SLC transporter disorders 2.174287e-01 0.663
R-HSA-190828 Gap junction trafficking 2.179348e-01 0.662
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 2.179348e-01 0.662
R-HSA-3928662 EPHB-mediated forward signaling 2.179348e-01 0.662
R-HSA-72306 tRNA processing 2.243560e-01 0.649
R-HSA-72165 mRNA Splicing - Minor Pathway 2.253064e-01 0.647
R-HSA-2299718 Condensation of Prophase Chromosomes 2.253064e-01 0.647
R-HSA-9649948 Signaling downstream of RAS mutants 2.253064e-01 0.647
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 2.253064e-01 0.647
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 2.253064e-01 0.647
R-HSA-6802949 Signaling by RAS mutants 2.253064e-01 0.647
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 2.253064e-01 0.647
R-HSA-9861718 Regulation of pyruvate metabolism 2.253064e-01 0.647
R-HSA-5357905 Regulation of TNFR1 signaling 2.253064e-01 0.647
R-HSA-1483191 Synthesis of PC 2.289664e-01 0.640
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 2.295633e-01 0.639
R-HSA-9764265 Regulation of CDH1 Expression and Function 2.295633e-01 0.639
R-HSA-5620924 Intraflagellar transport 2.326093e-01 0.633
R-HSA-389356 Co-stimulation by CD28 2.326093e-01 0.633
R-HSA-157858 Gap junction trafficking and regulation 2.362352e-01 0.627
R-HSA-1280218 Adaptive Immune System 2.380650e-01 0.623
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 2.398443e-01 0.620
R-HSA-912446 Meiotic recombination 2.434365e-01 0.614
R-HSA-9006925 Intracellular signaling by second messengers 2.441282e-01 0.612
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 2.470120e-01 0.607
R-HSA-5683057 MAPK family signaling cascades 2.504355e-01 0.601
R-HSA-1221632 Meiotic synapsis 2.505707e-01 0.601
R-HSA-8948751 Regulation of PTEN stability and activity 2.505707e-01 0.601
R-HSA-9694516 SARS-CoV-2 Infection 2.529657e-01 0.597
R-HSA-72649 Translation initiation complex formation 2.541129e-01 0.595
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 2.541129e-01 0.595
R-HSA-73929 Base-Excision Repair, AP Site Formation 2.541129e-01 0.595
R-HSA-3214815 HDACs deacetylate histones 2.576386e-01 0.589
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 2.576386e-01 0.589
R-HSA-9012852 Signaling by NOTCH3 2.576386e-01 0.589
R-HSA-168898 Toll-like Receptor Cascades 2.609474e-01 0.583
R-HSA-72702 Ribosomal scanning and start codon recognition 2.611478e-01 0.583
R-HSA-5578775 Ion homeostasis 2.611478e-01 0.583
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 2.611478e-01 0.583
R-HSA-75893 TNF signaling 2.611478e-01 0.583
R-HSA-68877 Mitotic Prometaphase 2.644427e-01 0.578
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 2.681172e-01 0.572
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.681172e-01 0.572
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 2.696863e-01 0.569
R-HSA-8979227 Triglyceride metabolism 2.715775e-01 0.566
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 2.750217e-01 0.561
R-HSA-8873719 RAB geranylgeranylation 2.750217e-01 0.561
R-HSA-983189 Kinesins 2.750217e-01 0.561
R-HSA-8943724 Regulation of PTEN gene transcription 2.750217e-01 0.561
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 2.750217e-01 0.561
R-HSA-450294 MAP kinase activation 2.784498e-01 0.555
R-HSA-112043 PLC beta mediated events 2.784498e-01 0.555
R-HSA-1268020 Mitochondrial protein import 2.818619e-01 0.550
R-HSA-373755 Semaphorin interactions 2.852581e-01 0.545
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 2.920030e-01 0.535
R-HSA-9824446 Viral Infection Pathways 2.976566e-01 0.526
R-HSA-112040 G-protein mediated events 2.986850e-01 0.525
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 3.085916e-01 0.511
R-HSA-195253 Degradation of beta-catenin by the destruction complex 3.085916e-01 0.511
R-HSA-204005 COPII-mediated vesicle transport 3.085916e-01 0.511
R-HSA-448424 Interleukin-17 signaling 3.085916e-01 0.511
R-HSA-9764560 Regulation of CDH1 Gene Transcription 3.085916e-01 0.511
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 3.085916e-01 0.511
R-HSA-418990 Adherens junctions interactions 3.098117e-01 0.509
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 3.118630e-01 0.506
R-HSA-189445 Metabolism of porphyrins 3.118630e-01 0.506
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 3.151192e-01 0.502
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.151192e-01 0.502
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 3.151192e-01 0.502
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 3.183601e-01 0.497
R-HSA-1266738 Developmental Biology 3.226612e-01 0.491
R-HSA-212436 Generic Transcription Pathway 3.233410e-01 0.490
R-HSA-8852135 Protein ubiquitination 3.247966e-01 0.488
R-HSA-917937 Iron uptake and transport 3.247966e-01 0.488
R-HSA-109582 Hemostasis 3.309606e-01 0.480
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.343390e-01 0.476
R-HSA-3247509 Chromatin modifying enzymes 3.374998e-01 0.472
R-HSA-9833482 PKR-mediated signaling 3.406266e-01 0.468
R-HSA-977225 Amyloid fiber formation 3.437484e-01 0.464
R-HSA-9707564 Cytoprotection by HMOX1 3.499483e-01 0.456
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 3.530265e-01 0.452
R-HSA-6802957 Oncogenic MAPK signaling 3.560903e-01 0.448
R-HSA-1500620 Meiosis 3.560903e-01 0.448
R-HSA-5687128 MAPK6/MAPK4 signaling 3.560903e-01 0.448
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.591398e-01 0.445
R-HSA-141424 Amplification of signal from the kinetochores 3.591398e-01 0.445
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 3.591398e-01 0.445
R-HSA-5619115 Disorders of transmembrane transporters 3.597647e-01 0.444
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 3.621751e-01 0.441
R-HSA-162582 Signal Transduction 3.624889e-01 0.441
R-HSA-4839726 Chromatin organization 3.631676e-01 0.440
R-HSA-70268 Pyruvate metabolism 3.651961e-01 0.437
R-HSA-390466 Chaperonin-mediated protein folding 3.651961e-01 0.437
R-HSA-421270 Cell-cell junction organization 3.665641e-01 0.436
R-HSA-156902 Peptide chain elongation 3.682031e-01 0.434
R-HSA-5688426 Deubiquitination 3.733369e-01 0.428
R-HSA-73884 Base Excision Repair 3.741749e-01 0.427
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 3.771399e-01 0.423
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 3.800910e-01 0.420
R-HSA-156842 Eukaryotic Translation Elongation 3.830283e-01 0.417
R-HSA-391251 Protein folding 3.830283e-01 0.417
R-HSA-68867 Assembly of the pre-replicative complex 3.859519e-01 0.413
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 3.859519e-01 0.413
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 3.917581e-01 0.407
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 3.917581e-01 0.407
R-HSA-72689 Formation of a pool of free 40S subunits 3.946408e-01 0.404
R-HSA-72764 Eukaryotic Translation Termination 3.946408e-01 0.404
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 3.946408e-01 0.404
R-HSA-9711123 Cellular response to chemical stress 3.951477e-01 0.403
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 3.975101e-01 0.401
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.975101e-01 0.401
R-HSA-157579 Telomere Maintenance 4.003659e-01 0.398
R-HSA-170834 Signaling by TGF-beta Receptor Complex 4.003659e-01 0.398
R-HSA-975871 MyD88 cascade initiated on plasma membrane 4.032084e-01 0.394
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 4.032084e-01 0.394
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 4.032084e-01 0.394
R-HSA-422356 Regulation of insulin secretion 4.032084e-01 0.394
R-HSA-3700989 Transcriptional Regulation by TP53 4.034838e-01 0.394
R-HSA-76002 Platelet activation, signaling and aggregation 4.051022e-01 0.392
R-HSA-69618 Mitotic Spindle Checkpoint 4.088535e-01 0.388
R-HSA-2408557 Selenocysteine synthesis 4.116563e-01 0.385
R-HSA-9009391 Extra-nuclear estrogen signaling 4.116563e-01 0.385
R-HSA-446728 Cell junction organization 4.116964e-01 0.385
R-HSA-9842860 Regulation of endogenous retroelements 4.144460e-01 0.383
R-HSA-9658195 Leishmania infection 4.166193e-01 0.380
R-HSA-9824443 Parasitic Infection Pathways 4.166193e-01 0.380
R-HSA-192823 Viral mRNA Translation 4.172226e-01 0.380
R-HSA-5663205 Infectious disease 4.191157e-01 0.378
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.199862e-01 0.377
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 4.199862e-01 0.377
R-HSA-111885 Opioid Signalling 4.199862e-01 0.377
R-HSA-9833110 RSV-host interactions 4.227369e-01 0.374
R-HSA-9692914 SARS-CoV-1-host interactions 4.281996e-01 0.368
R-HSA-5673001 RAF/MAP kinase cascade 4.296478e-01 0.367
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 4.309119e-01 0.366
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.309119e-01 0.366
R-HSA-9700206 Signaling by ALK in cancer 4.309119e-01 0.366
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 4.336114e-01 0.363
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.336114e-01 0.363
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 4.336114e-01 0.363
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 4.362983e-01 0.360
R-HSA-69002 DNA Replication Pre-Initiation 4.362983e-01 0.360
R-HSA-5684996 MAPK1/MAPK3 signaling 4.409248e-01 0.356
R-HSA-927802 Nonsense-Mediated Decay (NMD) 4.442838e-01 0.352
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 4.442838e-01 0.352
R-HSA-2871796 FCERI mediated MAPK activation 4.442838e-01 0.352
R-HSA-72737 Cap-dependent Translation Initiation 4.599212e-01 0.337
R-HSA-72613 Eukaryotic Translation Initiation 4.599212e-01 0.337
R-HSA-373760 L1CAM interactions 4.599212e-01 0.337
R-HSA-1592230 Mitochondrial biogenesis 4.624849e-01 0.335
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.660690e-01 0.332
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 4.675763e-01 0.330
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 4.675763e-01 0.330
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.726201e-01 0.325
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 4.751243e-01 0.323
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 4.751243e-01 0.323
R-HSA-9816359 Maternal to zygotic transition (MZT) 4.776168e-01 0.321
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 4.776168e-01 0.321
R-HSA-2132295 MHC class II antigen presentation 4.776168e-01 0.321
R-HSA-1852241 Organelle biogenesis and maintenance 4.786564e-01 0.320
R-HSA-114608 Platelet degranulation 4.899049e-01 0.310
R-HSA-199418 Negative regulation of the PI3K/AKT network 4.971404e-01 0.304
R-HSA-1474165 Reproduction 4.995296e-01 0.301
R-HSA-9843745 Adipogenesis 5.019077e-01 0.299
R-HSA-5576891 Cardiac conduction 5.019077e-01 0.299
R-HSA-9909396 Circadian clock 5.042746e-01 0.297
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 5.066304e-01 0.295
R-HSA-9679506 SARS-CoV Infections 5.140877e-01 0.289
R-HSA-163685 Integration of energy metabolism 5.159436e-01 0.287
R-HSA-9664422 FCGR3A-mediated phagocytosis 5.250833e-01 0.280
R-HSA-9664417 Leishmania phagocytosis 5.250833e-01 0.280
R-HSA-9664407 Parasite infection 5.250833e-01 0.280
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 5.273414e-01 0.278
R-HSA-199977 ER to Golgi Anterograde Transport 5.428547e-01 0.265
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.514927e-01 0.258
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.536269e-01 0.257
R-HSA-69306 DNA Replication 5.557511e-01 0.255
R-HSA-9609507 Protein localization 5.557511e-01 0.255
R-HSA-73887 Death Receptor Signaling 5.578653e-01 0.253
R-HSA-1989781 PPARA activates gene expression 5.599696e-01 0.252
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 5.641485e-01 0.249
R-HSA-9711097 Cellular response to starvation 5.662233e-01 0.247
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 5.662233e-01 0.247
R-HSA-877300 Interferon gamma signaling 5.682883e-01 0.245
R-HSA-9006936 Signaling by TGFB family members 5.703436e-01 0.244
R-HSA-556833 Metabolism of lipids 5.764207e-01 0.239
R-HSA-2467813 Separation of Sister Chromatids 5.784688e-01 0.238
R-HSA-2408522 Selenoamino acid metabolism 5.784688e-01 0.238
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.923245e-01 0.227
R-HSA-449147 Signaling by Interleukins 5.924068e-01 0.227
R-HSA-5689880 Ub-specific processing proteases 5.981242e-01 0.223
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 6.019453e-01 0.220
R-HSA-9678108 SARS-CoV-1 Infection 6.019453e-01 0.220
R-HSA-8978868 Fatty acid metabolism 6.030608e-01 0.220
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.259233e-01 0.203
R-HSA-5617833 Cilium Assembly 6.294835e-01 0.201
R-HSA-72766 Translation 6.305175e-01 0.200
R-HSA-948021 Transport to the Golgi and subsequent modification 6.501529e-01 0.187
R-HSA-376176 Signaling by ROBO receptors 6.518231e-01 0.186
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.518231e-01 0.186
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 6.610704e-01 0.180
R-HSA-9730414 MITF-M-regulated melanocyte development 6.696836e-01 0.174
R-HSA-597592 Post-translational protein modification 6.911469e-01 0.160
R-HSA-72312 rRNA processing 6.984285e-01 0.156
R-HSA-15869 Metabolism of nucleotides 7.041578e-01 0.152
R-HSA-1643685 Disease 7.155846e-01 0.145
R-HSA-392499 Metabolism of proteins 7.282203e-01 0.138
R-HSA-9734767 Developmental Cell Lineages 7.401180e-01 0.131
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.628019e-01 0.118
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.215006e-01 0.085
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.550044e-01 0.068
R-HSA-418594 G alpha (i) signalling events 8.709204e-01 0.060
R-HSA-1430728 Metabolism 8.782069e-01 0.056
R-HSA-446203 Asparagine N-linked glycosylation 8.799790e-01 0.056
R-HSA-71291 Metabolism of amino acids and derivatives 9.539167e-01 0.020
R-HSA-388396 GPCR downstream signalling 9.786751e-01 0.009
R-HSA-372790 Signaling by GPCR 9.858929e-01 0.006
R-HSA-382551 Transport of small molecules 9.924226e-01 0.003
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
BMPR1BBMPR1B 0.602 0.166 1 0.783
BMPR1ABMPR1A 0.595 0.165 1 0.765
CDC7CDC7 0.595 0.143 1 0.773
ALK2ALK2 0.592 0.175 -2 0.500
ACVR2BACVR2B 0.592 0.130 -2 0.500
TGFBR1TGFBR1 0.591 0.117 -2 0.500
ERK5ERK5 0.589 0.159 1 0.714
CLK3CLK3 0.588 0.019 1 0.684
MAPKAPK2MAPKAPK2 0.588 0.035 -3 0.500
RSK2RSK2 0.588 0.022 -3 0.500
ACVR2AACVR2A 0.587 0.112 -2 0.500
CLK2CLK2 0.587 0.055 -3 0.500
CAMK2DCAMK2D 0.585 0.058 -3 0.500
GRK1GRK1 0.585 0.036 -2 0.500
GRK5GRK5 0.585 0.041 -3 0.500
MOSMOS 0.585 0.029 1 0.739
DSTYKDSTYK 0.585 0.017 2 0.716
MSK1MSK1 0.585 0.026 -3 0.500
IKKBIKKB 0.584 0.022 -2 0.500
GRK6GRK6 0.584 0.084 1 0.701
MAPKAPK3MAPKAPK3 0.583 0.022 -3 0.500
PKACBPKACB 0.582 -0.000 -2 0.500
PIM3PIM3 0.582 -0.012 -3 0.500
CAMK2BCAMK2B 0.582 0.065 2 0.647
PDHK4PDHK4 0.582 0.019 1 0.635
LATS2LATS2 0.581 -0.004 -5 0.500
SBKSBK 0.581 0.018 -3 0.500
NDR2NDR2 0.581 -0.011 -3 0.500
COTCOT 0.581 -0.020 2 0.640
P90RSKP90RSK 0.581 0.005 -3 0.500
MTORMTOR 0.581 0.007 1 0.612
GRK3GRK3 0.581 0.045 -2 0.500
PRKD1PRKD1 0.581 0.001 -3 0.500
PRPKPRPK 0.581 -0.004 -1 0.124
CAMK2ACAMK2A 0.581 0.026 2 0.672
PRKXPRKX 0.580 -0.010 -3 0.500
ALK4ALK4 0.580 0.106 -2 0.500
CAMK2GCAMK2G 0.580 0.032 2 0.651
PKACAPKACA 0.580 0.004 -2 0.500
CK1DCK1D 0.580 -0.005 -3 0.500
CDKL5CDKL5 0.580 0.026 -3 0.500
CLK4CLK4 0.580 0.022 -3 0.500
SKMLCKSKMLCK 0.580 0.034 -2 0.500
RSK4RSK4 0.580 0.006 -3 0.500
SMG1SMG1 0.580 0.107 1 0.551
BMPR2BMPR2 0.579 0.097 -2 0.500
RSK3RSK3 0.579 -0.003 -3 0.500
GRK2GRK2 0.579 0.051 -2 0.500
GRK4GRK4 0.579 -0.002 -2 0.500
PAK6PAK6 0.579 0.050 -2 0.500
CDKL1CDKL1 0.579 0.013 -3 0.500
IKKAIKKA 0.579 0.007 -2 0.500
AURAAURA 0.579 0.014 -2 0.500
MAPKAPK5MAPKAPK5 0.578 0.041 -3 0.500
MSK2MSK2 0.578 -0.002 -3 0.500
AURCAURC 0.578 -0.015 -2 0.500
SRPK1SRPK1 0.577 0.011 -3 0.500
PIM1PIM1 0.577 -0.015 -3 0.500
FAM20CFAM20C 0.576 0.082 2 0.617
PRKD2PRKD2 0.576 -0.018 -3 0.500
SRPK2SRPK2 0.576 0.002 -3 0.500
CK1ECK1E 0.576 -0.016 -3 0.500
RAF1RAF1 0.575 -0.017 1 0.617
CAMK1BCAMK1B 0.575 -0.030 -3 0.500
CLK1CLK1 0.575 0.013 -3 0.500
CK2A2CK2A2 0.575 0.101 1 0.720
TGFBR2TGFBR2 0.575 0.009 -2 0.500
MYLK4MYLK4 0.574 0.009 -2 0.500
ATRATR 0.574 -0.015 1 0.611
P70S6KBP70S6KB 0.574 -0.024 -3 0.500
PKACGPKACG 0.574 -0.024 -2 0.500
CDK8CDK8 0.574 0.051 1 0.539
CAMLCKCAMLCK 0.574 0.022 -2 0.500
SRPK3SRPK3 0.574 0.016 -3 0.500
ICKICK 0.573 0.009 -3 0.500
DAPK2DAPK2 0.573 0.009 -3 0.500
P38BP38B 0.573 0.087 1 0.566
ATMATM 0.573 0.006 1 0.569
HIPK4HIPK4 0.573 -0.005 1 0.589
DYRK2DYRK2 0.573 0.039 1 0.550
CHK1CHK1 0.572 -0.014 -3 0.500
CDK19CDK19 0.572 0.057 1 0.507
AKT2AKT2 0.572 -0.012 -3 0.500
GRK7GRK7 0.571 -0.001 1 0.664
CK1A2CK1A2 0.571 -0.015 -3 0.500
LATS1LATS1 0.571 -0.004 -3 0.500
NDR1NDR1 0.571 -0.051 -3 0.500
PIM2PIM2 0.571 -0.012 -3 0.500
MASTLMASTL 0.571 0.002 -2 0.500
PDHK1PDHK1 0.570 -0.089 1 0.597
KISKIS 0.570 0.028 1 0.555
NLKNLK 0.570 0.025 1 0.636
JNK2JNK2 0.570 0.079 1 0.513
DYRK4DYRK4 0.570 0.056 1 0.511
PRKD3PRKD3 0.570 -0.025 -3 0.500
IKKEIKKE 0.570 -0.012 1 0.500
NUAK2NUAK2 0.569 -0.032 -3 0.500
CK2A1CK2A1 0.569 0.095 1 0.708
AURBAURB 0.569 -0.021 -2 0.500
CDK13CDK13 0.569 0.063 1 0.530
PKG2PKG2 0.569 -0.013 -2 0.500
JNK3JNK3 0.569 0.064 1 0.549
CK1ACK1A 0.569 -0.008 -3 0.500
DRAK1DRAK1 0.568 0.075 1 0.666
P38AP38A 0.568 0.070 1 0.588
PLK1PLK1 0.568 0.028 -2 0.500
CHAK2CHAK2 0.568 -0.038 -1 0.091
PRP4PRP4 0.568 0.028 -3 0.500
PAK4PAK4 0.568 0.037 -2 0.500
DNAPKDNAPK 0.567 0.030 1 0.474
PAK5PAK5 0.567 0.019 -2 0.500
TBK1TBK1 0.567 -0.026 1 0.499
NIKNIK 0.566 -0.056 -3 0.500
HUNKHUNK 0.566 -0.033 2 0.634
CDK7CDK7 0.566 0.020 1 0.553
PLK3PLK3 0.566 0.004 2 0.620
BCKDKBCKDK 0.566 -0.094 -1 0.090
NEK6NEK6 0.565 -0.079 -2 0.500
GCN2GCN2 0.565 -0.071 2 0.581
NEK7NEK7 0.565 -0.083 -3 0.500
DYRK3DYRK3 0.565 0.018 1 0.536
CDK9CDK9 0.565 0.061 1 0.529
DLKDLK 0.564 -0.023 1 0.639
WNK1WNK1 0.564 -0.051 -2 0.500
CAMK4CAMK4 0.564 -0.049 -3 0.500
PKN3PKN3 0.564 -0.052 -3 0.500
P38DP38D 0.564 0.072 1 0.463
CDK12CDK12 0.564 0.057 1 0.508
PAK1PAK1 0.564 -0.031 -2 0.500
P70S6KP70S6K 0.563 -0.025 -3 0.500
PASKPASK 0.563 0.020 -3 0.500
AKT3AKT3 0.563 -0.011 -3 0.500
MLK1MLK1 0.563 -0.033 2 0.603
SGK3SGK3 0.563 -0.022 -3 0.500
ERK1ERK1 0.563 0.047 1 0.536
SGK1SGK1 0.563 -0.012 -3 0.500
MAKMAK 0.562 0.026 -2 0.500
NEK9NEK9 0.562 0.001 2 0.596
CAMK1DCAMK1D 0.562 -0.032 -3 0.500
PAK3PAK3 0.562 -0.031 -2 0.500
DYRK1ADYRK1A 0.562 0.012 1 0.572
MARK4MARK4 0.561 -0.073 4 0.536
MEK1MEK1 0.561 0.003 2 0.633
ULK1ULK1 0.561 -0.048 -3 0.500
AMPKA1AMPKA1 0.561 -0.056 -3 0.500
ULK2ULK2 0.561 -0.088 2 0.541
TTBK2TTBK2 0.560 -0.033 2 0.516
AMPKA2AMPKA2 0.560 -0.050 -3 0.500
HIPK1HIPK1 0.560 0.007 1 0.551
DYRK1BDYRK1B 0.560 0.016 1 0.511
MNK2MNK2 0.560 -0.049 -2 0.500
RIPK3RIPK3 0.560 -0.046 3 0.705
PINK1PINK1 0.560 -0.025 1 0.582
DAPK1DAPK1 0.560 0.012 -3 0.500
TSSK2TSSK2 0.560 -0.060 -5 0.500
MLK2MLK2 0.560 -0.040 2 0.594
SMMLCKSMMLCK 0.559 -0.003 -3 0.500
PAK2PAK2 0.559 -0.030 -2 0.500
NEK2NEK2 0.559 0.001 2 0.587
BRAFBRAF 0.559 0.028 -4 0.500
P38GP38G 0.559 0.044 1 0.474
YSK4YSK4 0.559 -0.042 1 0.558
HIPK2HIPK2 0.558 0.007 1 0.483
PKN2PKN2 0.558 -0.067 -3 0.500
WNK3WNK3 0.558 -0.052 1 0.556
AKT1AKT1 0.558 -0.025 -3 0.500
CK1G1CK1G1 0.557 -0.041 -3 0.500
MST4MST4 0.557 -0.091 2 0.637
CDK18CDK18 0.557 0.014 1 0.500
DAPK3DAPK3 0.556 -0.007 -3 0.500
HIPK3HIPK3 0.556 0.012 1 0.533
CHK2CHK2 0.556 -0.020 -3 0.500
RIPK1RIPK1 0.556 -0.067 1 0.545
CDK1CDK1 0.556 0.013 1 0.546
PLK2PLK2 0.556 -0.008 -3 0.500
PKG1PKG1 0.556 -0.010 -2 0.500
TLK2TLK2 0.556 -0.060 1 0.539
MLK3MLK3 0.556 -0.016 2 0.549
MELKMELK 0.556 -0.053 -3 0.500
ERK2ERK2 0.556 0.031 1 0.559
JNK1JNK1 0.555 0.052 1 0.525
CAMKK1CAMKK1 0.555 0.022 -2 0.500
MRCKBMRCKB 0.555 -0.019 -3 0.500
SIKSIK 0.555 -0.071 -3 0.500
MOKMOK 0.554 0.022 1 0.583
ANKRD3ANKRD3 0.554 -0.128 1 0.597
LKB1LKB1 0.554 0.039 -3 0.500
BRSK1BRSK1 0.554 -0.041 -3 0.500
NIM1NIM1 0.554 -0.069 3 0.695
DCAMKL1DCAMKL1 0.553 -0.062 -3 0.500
NUAK1NUAK1 0.553 -0.076 -3 0.500
QIKQIK 0.553 -0.084 -3 0.500
CAMK1ACAMK1A 0.553 -0.038 -3 0.500
QSKQSK 0.553 -0.069 4 0.510
MNK1MNK1 0.553 -0.077 -2 0.500
PERKPERK 0.552 -0.034 -2 0.500
TSSK1TSSK1 0.552 -0.080 -3 0.500
PKCDPKCD 0.552 -0.069 2 0.554
CDK14CDK14 0.552 0.029 1 0.512
CAMKK2CAMKK2 0.551 0.002 -2 0.500
CDK17CDK17 0.550 0.015 1 0.472
CAMK1GCAMK1G 0.550 -0.076 -3 0.500
CDK10CDK10 0.550 0.012 1 0.500
MRCKAMRCKA 0.550 -0.036 -3 0.500
PHKG1PHKG1 0.549 -0.057 -3 0.500
VRK2VRK2 0.549 -0.120 1 0.631
PKCGPKCG 0.549 -0.074 2 0.539
MLK4MLK4 0.548 -0.072 2 0.512
MARK3MARK3 0.548 -0.067 4 0.462
CDK5CDK5 0.548 0.006 1 0.562
MEKK3MEKK3 0.547 -0.074 1 0.572
MARK2MARK2 0.547 -0.060 4 0.445
PKCBPKCB 0.547 -0.069 2 0.528
MARK1MARK1 0.547 -0.058 4 0.475
PKRPKR 0.547 -0.068 1 0.562
ERK7ERK7 0.547 0.019 2 0.382
TLK1TLK1 0.547 -0.108 -2 0.500
CK1G3CK1G3 0.547 -0.025 -3 0.500
HRIHRI 0.547 -0.084 -2 0.500
CRIKCRIK 0.546 -0.027 -3 0.500
SNRKSNRK 0.546 -0.065 2 0.489
PKCAPKCA 0.545 -0.067 2 0.517
GSK3BGSK3B 0.545 -0.014 4 0.337
WNK4WNK4 0.545 -0.024 -2 0.500
CHAK1CHAK1 0.545 -0.091 2 0.575
DCAMKL2DCAMKL2 0.545 -0.068 -3 0.500
TTBK1TTBK1 0.544 -0.058 2 0.453
BRSK2BRSK2 0.544 -0.077 -3 0.500
TAK1TAK1 0.544 0.050 1 0.598
NEK5NEK5 0.544 -0.037 1 0.559
PKN1PKN1 0.544 -0.040 -3 0.500
PKCZPKCZ 0.543 -0.098 2 0.547
ZAKZAK 0.543 -0.069 1 0.566
PKCHPKCH 0.543 -0.076 2 0.509
PLK4PLK4 0.543 -0.047 2 0.439
GSK3AGSK3A 0.543 -0.027 4 0.349
CDK16CDK16 0.543 -0.003 1 0.483
MEK5MEK5 0.543 -0.105 2 0.603
MEKK1MEKK1 0.543 -0.058 1 0.543
CDK2CDK2 0.542 -0.020 1 0.597
MST3MST3 0.542 -0.059 2 0.650
MPSK1MPSK1 0.542 -0.047 1 0.518
PDK1PDK1 0.542 -0.010 1 0.560
DMPK1DMPK1 0.542 -0.035 -3 0.500
HPK1HPK1 0.541 0.013 1 0.543
ROCK2ROCK2 0.541 -0.046 -3 0.500
GAKGAK 0.541 -0.034 1 0.613
TAO3TAO3 0.541 -0.081 1 0.572
NEK11NEK11 0.540 -0.028 1 0.564
IRAK1IRAK1 0.540 -0.093 -1 0.142
CDK3CDK3 0.540 0.007 1 0.493
PKCIPKCI 0.540 -0.060 2 0.518
NEK8NEK8 0.540 -0.041 2 0.594
SLKSLK 0.539 -0.048 -2 0.500
BUB1BUB1 0.539 -0.012 -5 0.500
GCKGCK 0.538 -0.016 1 0.563
TAO2TAO2 0.538 -0.033 2 0.622
CDK4CDK4 0.537 0.030 1 0.493
IRE1IRE1 0.537 -0.125 1 0.516
MEKK2MEKK2 0.537 -0.081 2 0.565
RIPK2RIPK2 0.537 -0.028 1 0.505
PKCEPKCE 0.537 -0.061 2 0.530
MEK2MEK2 0.536 -0.021 2 0.579
ROCK1ROCK1 0.536 -0.036 -3 0.500
PBKPBK 0.536 -0.014 1 0.530
PHKG2PHKG2 0.536 -0.086 -3 0.500
PKCTPKCT 0.536 -0.084 2 0.502
LOKLOK 0.535 -0.038 -2 0.500
MST2MST2 0.535 -0.083 1 0.570
CK1G2CK1G2 0.535 -0.055 -3 0.500
NEK4NEK4 0.534 -0.027 1 0.498
CDK6CDK6 0.533 0.018 1 0.490
EEF2KEEF2K 0.533 -0.020 3 0.715
NEK1NEK1 0.533 0.009 1 0.525
SSTKSSTK 0.533 -0.103 4 0.489
MEKK6MEKK6 0.532 -0.057 1 0.589
LRRK2LRRK2 0.532 -0.079 2 0.630
NEK3NEK3 0.532 -0.002 1 0.502
TNIKTNIK 0.532 -0.021 3 0.749
IRE2IRE2 0.531 -0.112 2 0.479
HGKHGK 0.531 -0.035 3 0.751
IRAK4IRAK4 0.530 -0.110 1 0.511
MINKMINK 0.529 -0.041 1 0.527
STK33STK33 0.529 -0.065 2 0.450
MAP3K15MAP3K15 0.527 -0.099 1 0.550
ALPHAK3ALPHAK3 0.527 -0.032 -1 0.099
KHS2KHS2 0.526 -0.021 1 0.528
KHS1KHS1 0.526 -0.038 1 0.513
MST1MST1 0.524 -0.102 1 0.535
VRK1VRK1 0.522 -0.095 2 0.588
YSK1YSK1 0.521 -0.061 2 0.581
BIKEBIKE 0.521 -0.010 1 0.489
OSR1OSR1 0.518 -0.079 2 0.551
YANK3YANK3 0.518 -0.044 2 0.299
HASPINHASPIN 0.516 -0.088 -1 0.075
ASK1ASK1 0.516 -0.068 1 0.553
TAO1TAO1 0.514 -0.042 1 0.481
MYO3BMYO3B 0.513 -0.028 2 0.597
TTKTTK 0.513 -0.084 -2 0.500
AAK1AAK1 0.510 -0.017 1 0.404
MYO3AMYO3A 0.507 -0.063 1 0.483
STLK3STLK3 0.504 -0.087 1 0.515
TXKTXK 0.504 0.133 1 0.748
YANK2YANK2 0.501 -0.052 2 0.308
SRMSSRMS 0.501 0.137 1 0.731
MAP2K4_TYRMAP2K4_TYR 0.500 0.084 -1 0.136
MAP2K6_TYRMAP2K6_TYR 0.499 0.042 -1 0.114
PDHK3_TYRPDHK3_TYR 0.498 0.024 4 0.654
EPHA4EPHA4 0.495 0.051 2 0.648
BMPR2_TYRBMPR2_TYR 0.495 -0.014 -1 0.097
PDHK1_TYRPDHK1_TYR 0.494 -0.021 -1 0.103
FERFER 0.493 0.060 1 0.733
EPHB4EPHB4 0.492 0.020 -1 0.103
PDHK4_TYRPDHK4_TYR 0.492 -0.032 2 0.687
EPHB3EPHB3 0.491 0.039 -1 0.109
SYKSYK 0.491 0.012 -1 0.071
EPHA6EPHA6 0.491 -0.011 -1 0.090
EPHB1EPHB1 0.490 0.041 1 0.719
BMXBMX 0.490 0.033 -1 0.116
MAP2K7_TYRMAP2K7_TYR 0.490 -0.083 2 0.669
EPHB2EPHB2 0.489 0.021 -1 0.098
TESK1_TYRTESK1_TYR 0.489 -0.079 3 0.770
MERTKMERTK 0.488 0.061 3 0.731
EPHA5EPHA5 0.488 0.036 2 0.634
ITKITK 0.488 0.051 -1 0.141
PTK2PTK2 0.487 0.015 -1 0.065
TECTEC 0.487 0.040 -1 0.151
TNK2TNK2 0.486 0.066 3 0.714
EPHA7EPHA7 0.485 0.021 2 0.624
PTK2BPTK2B 0.485 0.037 -1 0.113
BLKBLK 0.485 0.015 -1 0.118
LIMK2_TYRLIMK2_TYR 0.485 -0.052 -3 0.500
ABL2ABL2 0.485 0.010 -1 0.125
BTKBTK 0.485 0.045 -1 0.178
HCKHCK 0.484 -0.007 -1 0.130
PINK1_TYRPINK1_TYR 0.484 -0.127 1 0.648
YES1YES1 0.484 -0.005 -1 0.131
PKMYT1_TYRPKMYT1_TYR 0.484 -0.139 3 0.766
FYNFYN 0.483 -0.014 -1 0.091
FGRFGR 0.482 -0.042 1 0.663
LCKLCK 0.482 -0.029 -1 0.105
DDR1DDR1 0.482 -0.060 4 0.563
ABL1ABL1 0.482 0.001 -1 0.130
EPHA3EPHA3 0.482 -0.018 2 0.610
MATKMATK 0.481 -0.023 -1 0.102
AXLAXL 0.481 0.014 3 0.727
EPHA8EPHA8 0.481 -0.017 -1 0.084
TYRO3TYRO3 0.480 -0.024 3 0.717
NTRK1NTRK1 0.480 -0.023 -1 0.107
EPHA2EPHA2 0.480 0.001 -1 0.080
NTRK3NTRK3 0.479 -0.029 -1 0.086
INSRRINSRR 0.479 -0.046 3 0.687
LYNLYN 0.479 -0.022 3 0.680
TEKTEK 0.478 0.030 3 0.672
KITKIT 0.478 -0.065 3 0.738
EPHA1EPHA1 0.477 -0.001 3 0.734
CSF1RCSF1R 0.477 -0.067 3 0.742
LIMK1_TYRLIMK1_TYR 0.476 -0.162 2 0.631
FLT1FLT1 0.476 -0.091 -1 0.074
RETRET 0.476 -0.140 1 0.578
FGFR2FGFR2 0.475 -0.087 3 0.730
CSKCSK 0.475 -0.038 2 0.618
SRCSRC 0.475 -0.037 -1 0.098
FRKFRK 0.474 -0.027 -1 0.135
MST1RMST1R 0.474 -0.126 3 0.751
FGFR4FGFR4 0.473 -0.040 -1 0.093
JAK2JAK2 0.473 -0.115 1 0.581
EGFREGFR 0.473 -0.041 1 0.551
FGFR3FGFR3 0.473 -0.065 3 0.710
ZAP70ZAP70 0.472 -0.037 -1 0.052
JAK3JAK3 0.472 -0.139 1 0.604
TYK2TYK2 0.472 -0.128 1 0.572
METMET 0.472 -0.085 3 0.728
ROS1ROS1 0.471 -0.088 3 0.707
ERBB2ERBB2 0.471 -0.072 1 0.594
LTKLTK 0.470 -0.045 3 0.688
PTK6PTK6 0.470 -0.107 -1 0.101
NTRK2NTRK2 0.469 -0.073 3 0.698
ERBB4ERBB4 0.468 -0.025 1 0.595
FLT3FLT3 0.468 -0.089 3 0.731
NEK10_TYRNEK10_TYR 0.468 -0.070 1 0.508
FESFES 0.468 -0.012 -1 0.105
WEE1_TYRWEE1_TYR 0.467 -0.070 -1 0.122
FGFR1FGFR1 0.467 -0.113 3 0.711
KDRKDR 0.466 -0.124 3 0.720
PDGFRBPDGFRB 0.465 -0.120 3 0.735
TNK1TNK1 0.465 -0.088 3 0.718
JAK1JAK1 0.465 -0.056 1 0.520
ALKALK 0.464 -0.081 3 0.658
FLT4FLT4 0.463 -0.117 3 0.710
INSRINSR 0.463 -0.090 3 0.676
DDR2DDR2 0.462 -0.063 3 0.673
IGF1RIGF1R 0.461 -0.057 3 0.617
PDGFRAPDGFRA 0.461 -0.139 3 0.726
TNNI3K_TYRTNNI3K_TYR 0.458 -0.132 1 0.553
MUSKMUSK 0.453 -0.089 1 0.530