Motif 1215 (n=68)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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A0A0A6YYG9 | ARPC4-TTLL3 | T2 | ochoa | Protein ARPC4-TTLL3 | None |
A8CG34 | POM121C | S2 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
O00193 | SMAP | S2 | ochoa | Small acidic protein | None |
O60264 | SMARCA5 | S2 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
O60664 | PLIN3 | S2 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
O75431 | MTX2 | S2 | ochoa | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | Involved in transport of proteins into the mitochondrion. {ECO:0000269|PubMed:10381257}. |
O95777 | LSM8 | T2 | ochoa | U6 snRNA-associated Sm-like protein LSm8 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
P05412 | JUN | T2 | psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
P08621 | SNRNP70 | T2 | ochoa | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}. |
P10412 | H1-4 | S2 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P16152 | CBR1 | S2 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
P16401 | H1-5 | S2 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P16402 | H1-3 | S2 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P16403 | H1-2 | S2 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P16989 | YBX3 | S2 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
P18754 | RCC1 | S2 | psp | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
P19532 | TFE3 | S2 | ochoa | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
P24844 | MYL9 | S2 | psp | Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}. |
P28289 | TMOD1 | S2 | psp | Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}. |
P30519 | HMOX2 | S2 | ochoa | Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form] | [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}. |
P35659 | DEK | S2 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
P43351 | RAD52 | S2 | ochoa | DNA repair protein RAD52 homolog | Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:8702565}. |
P46782 | RPS5 | T2 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
P46940 | IQGAP1 | S2 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
P47712 | PLA2G4A | S2 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
P51397 | DAP | S2 | ochoa | Death-associated protein 1 (DAP-1) | Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}. |
P51911 | CNN1 | S2 | ochoa | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. |
P52926 | HMGA2 | S2 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
P56962 | STX17 | S2 | psp | Syntaxin-17 | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:28504273}. |
P59998 | ARPC4 | T2 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
P67809 | YBX1 | S2 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
P67870 | CSNK2B | S2 | ochoa|psp | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}. |
P80217 | IFI35 | S2 | ochoa | Interferon-induced 35 kDa protein (IFP 35) (Ifi-35) | Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}. |
P98082 | DAB2 | S2 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
Q02539 | H1-1 | S2 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
Q03169 | TNFAIP2 | S2 | ochoa | Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) | May play a role as a mediator of inflammation and angiogenesis. |
Q08752 | PPID | S2 | ochoa | Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}. |
Q13393 | PLD1 | S2 | psp | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
Q13542 | EIF4EBP2 | S2 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
Q15172 | PPP2R5A | S2 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q15573 | TAF1A | S2 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}. |
Q15717 | ELAVL1 | S2 | ochoa | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
Q6ZN55 | ZNF574 | T2 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
Q7KZI7 | MARK2 | S2 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q86VP1 | TAX1BP1 | T2 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
Q8N9B5 | JMY | S2 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
Q8NA72 | POC5 | S2 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
Q8NDC0 | MAPK1IP1L | S2 | ochoa | MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like) | None |
Q8WUD1 | RAB2B | T2 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
Q92522 | H1-10 | S2 | ochoa | Histone H1.10 (Histone H1x) | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. |
Q92609 | TBC1D5 | Y2 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
Q96AJ9 | VTI1A | S2 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
Q96HA1 | POM121 | S2 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
Q96HR3 | MED30 | S2 | ochoa | Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:11909976, ECO:0000269|PubMed:16595664}. |
Q96P16 | RPRD1A | S2 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
Q96SN7 | ORAI2 | S2 | ochoa | Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B) | Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:17452328, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685}. |
Q99439 | CNN2 | S2 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
Q99536 | VAT1 | S2 | ochoa | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
Q9BY11 | PACSIN1 | S2 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
Q9H773 | DCTPP1 | S2 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
Q9H8Y5 | ANKZF1 | S2 | ochoa | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
Q9NQ86 | TRIM36 | S2 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
Q9NQG5 | RPRD1B | S2 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
Q9NR55 | BATF3 | S2 | ochoa | Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (21 kDa small nuclear factor isolated from T-cells) (Jun dimerization protein p21SNFT) | AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269|PubMed:10878360, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742}. |
Q9NWU2 | GID8 | S2 | ochoa | Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). {ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}. |
Q9NXR7 | BABAM2 | S2 | ochoa | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:19261748, PubMed:21282113). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000305|PubMed:15465831}. |
Q9UNF1 | MAGED2 | S2 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
Q9Y2V2 | CARHSP1 | S2 | ochoa | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.840775e-10 | 9.547 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.039852e-09 | 8.219 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.932503e-08 | 7.307 |
R-HSA-2559583 | Cellular Senescence | 4.857405e-06 | 5.314 |
R-HSA-75153 | Apoptotic execution phase | 6.426459e-06 | 5.192 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.125393e-04 | 3.673 |
R-HSA-109581 | Apoptosis | 2.184409e-04 | 3.661 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.608761e-04 | 3.251 |
R-HSA-5357801 | Programmed Cell Death | 7.053934e-04 | 3.152 |
R-HSA-180746 | Nuclear import of Rev protein | 1.009879e-03 | 2.996 |
R-HSA-2262752 | Cellular responses to stress | 1.097460e-03 | 2.960 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.317332e-03 | 2.880 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.490812e-03 | 2.827 |
R-HSA-8953897 | Cellular responses to stimuli | 3.046888e-03 | 2.516 |
R-HSA-1483166 | Synthesis of PA | 3.711620e-03 | 2.430 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.037668e-03 | 2.394 |
R-HSA-1483148 | Synthesis of PG | 4.545990e-03 | 2.342 |
R-HSA-5693606 | DNA Double Strand Break Response | 5.513563e-03 | 2.259 |
R-HSA-432142 | Platelet sensitization by LDL | 5.420064e-03 | 2.266 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.717858e-03 | 2.243 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.357814e-03 | 2.197 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.580241e-03 | 2.182 |
R-HSA-5602566 | TICAM1 deficiency - HSE | 9.395406e-03 | 2.027 |
R-HSA-5602571 | TRAF3 deficiency - HSE | 1.406039e-02 | 1.852 |
R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 2.792565e-02 | 1.554 |
R-HSA-9017802 | Noncanonical activation of NOTCH3 | 3.706207e-02 | 1.431 |
R-HSA-2562578 | TRIF-mediated programmed cell death | 4.611374e-02 | 1.336 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 5.060803e-02 | 1.296 |
R-HSA-111995 | phospho-PLA2 pathway | 5.060803e-02 | 1.296 |
R-HSA-196025 | Formation of annular gap junctions | 5.060803e-02 | 1.296 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 5.508143e-02 | 1.259 |
R-HSA-9613354 | Lipophagy | 5.508143e-02 | 1.259 |
R-HSA-190873 | Gap junction degradation | 5.508143e-02 | 1.259 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 5.953402e-02 | 1.225 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 6.396591e-02 | 1.194 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 6.396591e-02 | 1.194 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 6.396591e-02 | 1.194 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 6.837719e-02 | 1.165 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 6.837719e-02 | 1.165 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 7.276795e-02 | 1.138 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 7.276795e-02 | 1.138 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 7.276795e-02 | 1.138 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 7.276795e-02 | 1.138 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 7.276795e-02 | 1.138 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.276530e-02 | 1.894 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.344361e-02 | 1.871 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.344361e-02 | 1.871 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 8.581807e-02 | 1.066 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 8.581807e-02 | 1.066 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 8.581807e-02 | 1.066 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.484619e-02 | 1.828 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.484619e-02 | 1.828 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.557017e-02 | 1.808 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.706272e-02 | 1.768 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.022198e-02 | 1.694 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.104721e-02 | 1.677 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.071666e-01 | 0.970 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.298555e-02 | 1.482 |
R-HSA-171306 | Packaging Of Telomere Ends | 1.443614e-01 | 0.841 |
R-HSA-5334118 | DNA methylation | 1.524169e-01 | 0.817 |
R-HSA-9615710 | Late endosomal microautophagy | 1.524169e-01 | 0.817 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.683040e-01 | 0.774 |
R-HSA-390522 | Striated Muscle Contraction | 1.722297e-01 | 0.764 |
R-HSA-72172 | mRNA Splicing | 8.982660e-02 | 1.047 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.786304e-02 | 1.168 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 8.004347e-02 | 1.097 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.417716e-01 | 0.848 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.417716e-01 | 0.848 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 6.837719e-02 | 1.165 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 9.441728e-02 | 1.025 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.417716e-01 | 0.848 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.861373e-02 | 1.730 |
R-HSA-389513 | Co-inhibition by CTLA4 | 1.113769e-01 | 0.953 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.373226e-02 | 1.862 |
R-HSA-6798695 | Neutrophil degranulation | 2.558274e-02 | 1.592 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 8.526917e-03 | 2.069 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.443614e-01 | 0.841 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.645923e-02 | 1.248 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 1.044062e-01 | 0.981 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.044062e-01 | 0.981 |
R-HSA-73864 | RNA Polymerase I Transcription | 6.270516e-02 | 1.203 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.017927e-02 | 1.221 |
R-HSA-212165 | Epigenetic regulation of gene expression | 2.329234e-02 | 1.633 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 5.508143e-02 | 1.259 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.450042e-02 | 1.128 |
R-HSA-4839744 | Signaling by APC mutants | 6.396591e-02 | 1.194 |
R-HSA-4839748 | Signaling by AMER1 mutants | 6.837719e-02 | 1.165 |
R-HSA-4839735 | Signaling by AXIN mutants | 6.837719e-02 | 1.165 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.861373e-02 | 1.730 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.628482e-02 | 1.580 |
R-HSA-774815 | Nucleosome assembly | 2.628482e-02 | 1.580 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.628482e-02 | 1.580 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.813631e-02 | 1.551 |
R-HSA-8949613 | Cristae formation | 1.443614e-01 | 0.841 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.443614e-01 | 0.841 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.524169e-01 | 0.817 |
R-HSA-4791275 | Signaling by WNT in cancer | 1.643600e-01 | 0.784 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 4.098260e-02 | 1.387 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 1.029367e-01 | 0.987 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.811610e-02 | 1.318 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.029367e-01 | 0.987 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.020907e-02 | 1.991 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.557017e-02 | 1.808 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 9.868690e-02 | 1.006 |
R-HSA-9948299 | Ribosome-associated quality control | 1.663777e-01 | 0.779 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 1.134707e-01 | 0.945 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.059026e-01 | 0.975 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.134707e-01 | 0.945 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 8.899015e-03 | 2.051 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 6.396591e-02 | 1.194 |
R-HSA-1483115 | Hydrolysis of LPC | 8.148829e-02 | 1.089 |
R-HSA-5689901 | Metalloprotease DUBs | 1.403054e-01 | 0.853 |
R-HSA-194441 | Metabolism of non-coding RNA | 4.027746e-02 | 1.395 |
R-HSA-191859 | snRNP Assembly | 4.027746e-02 | 1.395 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 4.246317e-02 | 1.372 |
R-HSA-9609690 | HCMV Early Events | 8.178554e-02 | 1.087 |
R-HSA-445355 | Smooth Muscle Contraction | 3.399212e-02 | 1.469 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.908123e-02 | 1.536 |
R-HSA-68875 | Mitotic Prophase | 2.583242e-02 | 1.588 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.023972e-02 | 1.694 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.443614e-01 | 0.841 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.887883e-02 | 1.311 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.786304e-02 | 1.168 |
R-HSA-3214847 | HATs acetylate histones | 9.555638e-02 | 1.020 |
R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 3.250450e-02 | 1.488 |
R-HSA-201688 | WNT mediated activation of DVL | 5.508143e-02 | 1.259 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 6.837719e-02 | 1.165 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 7.276795e-02 | 1.138 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 8.581807e-02 | 1.066 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.104721e-02 | 1.677 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.188631e-02 | 1.660 |
R-HSA-1482801 | Acyl chain remodelling of PS | 1.362303e-01 | 0.866 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.443614e-01 | 0.841 |
R-HSA-418360 | Platelet calcium homeostasis | 1.524169e-01 | 0.817 |
R-HSA-68886 | M Phase | 1.208854e-02 | 1.918 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 9.995327e-02 | 1.000 |
R-HSA-1482788 | Acyl chain remodelling of PC | 1.722297e-01 | 0.764 |
R-HSA-9018519 | Estrogen-dependent gene expression | 1.630528e-01 | 0.788 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 8.148829e-02 | 1.089 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.720412e-02 | 1.565 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.643600e-01 | 0.784 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.683040e-01 | 0.774 |
R-HSA-8953854 | Metabolism of RNA | 1.091400e-01 | 0.962 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.933269e-02 | 1.533 |
R-HSA-9609646 | HCMV Infection | 1.356038e-01 | 0.868 |
R-HSA-8939211 | ESR-mediated signaling | 3.363251e-02 | 1.473 |
R-HSA-397014 | Muscle contraction | 2.436175e-02 | 1.613 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.524169e-01 | 0.817 |
R-HSA-68882 | Mitotic Anaphase | 1.010429e-01 | 0.995 |
R-HSA-73886 | Chromosome Maintenance | 1.337601e-01 | 0.874 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.683040e-01 | 0.774 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.020022e-01 | 0.991 |
R-HSA-199991 | Membrane Trafficking | 1.359090e-02 | 1.867 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.205367e-02 | 1.657 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.022198e-02 | 1.694 |
R-HSA-1482922 | Acyl chain remodelling of PI | 1.113769e-01 | 0.953 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.280231e-01 | 0.893 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.321363e-01 | 0.879 |
R-HSA-69473 | G2/M DNA damage checkpoint | 5.768992e-02 | 1.239 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.526671e-02 | 1.185 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.356110e-02 | 1.197 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.547967e-01 | 0.810 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.188692e-02 | 1.378 |
R-HSA-5693538 | Homology Directed Repair | 2.485709e-02 | 1.605 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.200976e-02 | 1.208 |
R-HSA-5653656 | Vesicle-mediated transport | 4.160613e-02 | 1.381 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 3.813637e-02 | 1.419 |
R-HSA-389948 | Co-inhibition by PD-1 | 8.531896e-02 | 1.069 |
R-HSA-8934903 | Receptor Mediated Mitophagy | 5.953402e-02 | 1.225 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.113769e-01 | 0.953 |
R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.321363e-01 | 0.879 |
R-HSA-6784531 | tRNA processing in the nucleus | 4.357244e-02 | 1.361 |
R-HSA-73894 | DNA Repair | 1.053361e-01 | 0.977 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.238906e-01 | 0.907 |
R-HSA-418346 | Platelet homeostasis | 1.860172e-02 | 1.730 |
R-HSA-1483249 | Inositol phosphate metabolism | 1.165367e-01 | 0.934 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 7.713829e-02 | 1.113 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 2.114936e-02 | 1.675 |
R-HSA-168255 | Influenza Infection | 6.751800e-02 | 1.171 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 6.656058e-02 | 1.177 |
R-HSA-74160 | Gene expression (Transcription) | 4.390212e-02 | 1.358 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 1.075983e-01 | 0.968 |
R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 9.012770e-02 | 1.045 |
R-HSA-9664420 | Killing mechanisms | 9.012770e-02 | 1.045 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 9.012770e-02 | 1.045 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.357244e-02 | 1.361 |
R-HSA-162909 | Host Interactions of HIV factors | 2.784429e-02 | 1.555 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.133676e-02 | 1.090 |
R-HSA-9663891 | Selective autophagy | 7.721180e-02 | 1.112 |
R-HSA-1482925 | Acyl chain remodelling of PG | 1.155676e-01 | 0.937 |
R-HSA-168249 | Innate Immune System | 5.178580e-02 | 1.286 |
R-HSA-69620 | Cell Cycle Checkpoints | 1.442701e-01 | 0.841 |
R-HSA-1640170 | Cell Cycle | 2.159438e-02 | 1.666 |
R-HSA-3928664 | Ephrin signaling | 1.029367e-01 | 0.987 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.029367e-01 | 0.987 |
R-HSA-445144 | Signal transduction by L1 | 1.113769e-01 | 0.953 |
R-HSA-70171 | Glycolysis | 9.701563e-02 | 1.013 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.180777e-01 | 0.928 |
R-HSA-1482798 | Acyl chain remodeling of CL | 8.148829e-02 | 1.089 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 1.242927e-01 | 0.906 |
R-HSA-69481 | G2/M Checkpoints | 1.450051e-01 | 0.839 |
R-HSA-909733 | Interferon alpha/beta signaling | 1.242927e-01 | 0.906 |
R-HSA-373753 | Nephrin family interactions | 1.113769e-01 | 0.953 |
R-HSA-400685 | Sema4D in semaphorin signaling | 1.362303e-01 | 0.866 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.603976e-01 | 0.795 |
R-HSA-1483257 | Phospholipid metabolism | 6.212447e-02 | 1.207 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.722297e-01 | 0.764 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.995327e-02 | 1.000 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.104265e-01 | 0.957 |
R-HSA-69278 | Cell Cycle, Mitotic | 5.903436e-02 | 1.229 |
R-HSA-1169408 | ISG15 antiviral mechanism | 5.892997e-02 | 1.230 |
R-HSA-1632852 | Macroautophagy | 1.713876e-01 | 0.766 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.403054e-01 | 0.853 |
R-HSA-168256 | Immune System | 8.535733e-03 | 2.069 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 7.076324e-02 | 1.150 |
R-HSA-9645723 | Diseases of programmed cell death | 7.721180e-02 | 1.112 |
R-HSA-2682334 | EPH-Ephrin signaling | 1.267187e-02 | 1.897 |
R-HSA-6807070 | PTEN Regulation | 1.680448e-01 | 0.775 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.119459e-01 | 0.951 |
R-HSA-9828806 | Maturation of hRSV A proteins | 1.443614e-01 | 0.841 |
R-HSA-211000 | Gene Silencing by RNA | 1.901536e-02 | 1.721 |
R-HSA-70326 | Glucose metabolism | 1.274298e-01 | 0.895 |
R-HSA-913531 | Interferon Signaling | 1.222473e-02 | 1.913 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.180777e-01 | 0.928 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.227314e-01 | 0.911 |
R-HSA-8863678 | Neurodegenerative Diseases | 1.321363e-01 | 0.879 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.321363e-01 | 0.879 |
R-HSA-189483 | Heme degradation | 1.722297e-01 | 0.764 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 1.127932e-01 | 0.948 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.443614e-01 | 0.841 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 4.035638e-02 | 1.394 |
R-HSA-162906 | HIV Infection | 1.117945e-01 | 0.952 |
R-HSA-157118 | Signaling by NOTCH | 1.250419e-01 | 0.903 |
R-HSA-3371556 | Cellular response to heat stress | 1.337601e-01 | 0.874 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.647137e-01 | 0.783 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.819416e-02 | 1.317 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.696445e-02 | 1.328 |
R-HSA-162587 | HIV Life Cycle | 5.026256e-02 | 1.299 |
R-HSA-422475 | Axon guidance | 1.293241e-01 | 0.888 |
R-HSA-9675108 | Nervous system development | 1.560011e-01 | 0.807 |
R-HSA-9020591 | Interleukin-12 signaling | 6.017927e-02 | 1.221 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 7.245226e-02 | 1.140 |
R-HSA-447115 | Interleukin-12 family signaling | 7.585218e-02 | 1.120 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.747417e-01 | 0.758 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.761370e-01 | 0.754 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.761370e-01 | 0.754 |
R-HSA-5673000 | RAF activation | 1.761370e-01 | 0.754 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.761370e-01 | 0.754 |
R-HSA-392518 | Signal amplification | 1.761370e-01 | 0.754 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.761370e-01 | 0.754 |
R-HSA-5205647 | Mitophagy | 1.761370e-01 | 0.754 |
R-HSA-1482839 | Acyl chain remodelling of PE | 1.800262e-01 | 0.745 |
R-HSA-73857 | RNA Polymerase II Transcription | 1.823475e-01 | 0.739 |
R-HSA-212300 | PRC2 methylates histones and DNA | 1.838972e-01 | 0.735 |
R-HSA-163560 | Triglyceride catabolism | 1.838972e-01 | 0.735 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.848671e-01 | 0.733 |
R-HSA-1257604 | PIP3 activates AKT signaling | 1.865330e-01 | 0.729 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.877502e-01 | 0.726 |
R-HSA-110331 | Cleavage of the damaged purine | 1.877502e-01 | 0.726 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.877502e-01 | 0.726 |
R-HSA-195721 | Signaling by WNT | 1.900967e-01 | 0.721 |
R-HSA-73927 | Depurination | 1.915853e-01 | 0.718 |
R-HSA-2142753 | Arachidonate metabolism | 1.916649e-01 | 0.717 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.950767e-01 | 0.710 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.954025e-01 | 0.709 |
R-HSA-9612973 | Autophagy | 1.984965e-01 | 0.702 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.992019e-01 | 0.701 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.992019e-01 | 0.701 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.992019e-01 | 0.701 |
R-HSA-5260271 | Diseases of Immune System | 1.992019e-01 | 0.701 |
R-HSA-9610379 | HCMV Late Events | 2.002093e-01 | 0.699 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.029835e-01 | 0.693 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.029835e-01 | 0.693 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.029835e-01 | 0.693 |
R-HSA-5633007 | Regulation of TP53 Activity | 2.053583e-01 | 0.687 |
R-HSA-5674135 | MAP2K and MAPK activation | 2.067476e-01 | 0.685 |
R-HSA-9656223 | Signaling by RAF1 mutants | 2.067476e-01 | 0.685 |
R-HSA-6811438 | Intra-Golgi traffic | 2.067476e-01 | 0.685 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 2.067476e-01 | 0.685 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.104941e-01 | 0.677 |
R-HSA-111996 | Ca-dependent events | 2.104941e-01 | 0.677 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.104941e-01 | 0.677 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.104941e-01 | 0.677 |
R-HSA-73928 | Depyrimidination | 2.104941e-01 | 0.677 |
R-HSA-1500931 | Cell-Cell communication | 2.118339e-01 | 0.674 |
R-HSA-9710421 | Defective pyroptosis | 2.142232e-01 | 0.669 |
R-HSA-5619102 | SLC transporter disorders | 2.174287e-01 | 0.663 |
R-HSA-190828 | Gap junction trafficking | 2.179348e-01 | 0.662 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.179348e-01 | 0.662 |
R-HSA-3928662 | EPHB-mediated forward signaling | 2.179348e-01 | 0.662 |
R-HSA-72306 | tRNA processing | 2.243560e-01 | 0.649 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.253064e-01 | 0.647 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.253064e-01 | 0.647 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 2.253064e-01 | 0.647 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.253064e-01 | 0.647 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.253064e-01 | 0.647 |
R-HSA-6802949 | Signaling by RAS mutants | 2.253064e-01 | 0.647 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.253064e-01 | 0.647 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 2.253064e-01 | 0.647 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 2.253064e-01 | 0.647 |
R-HSA-1483191 | Synthesis of PC | 2.289664e-01 | 0.640 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.295633e-01 | 0.639 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.295633e-01 | 0.639 |
R-HSA-5620924 | Intraflagellar transport | 2.326093e-01 | 0.633 |
R-HSA-389356 | Co-stimulation by CD28 | 2.326093e-01 | 0.633 |
R-HSA-157858 | Gap junction trafficking and regulation | 2.362352e-01 | 0.627 |
R-HSA-1280218 | Adaptive Immune System | 2.380650e-01 | 0.623 |
R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 2.398443e-01 | 0.620 |
R-HSA-912446 | Meiotic recombination | 2.434365e-01 | 0.614 |
R-HSA-9006925 | Intracellular signaling by second messengers | 2.441282e-01 | 0.612 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.470120e-01 | 0.607 |
R-HSA-5683057 | MAPK family signaling cascades | 2.504355e-01 | 0.601 |
R-HSA-1221632 | Meiotic synapsis | 2.505707e-01 | 0.601 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 2.505707e-01 | 0.601 |
R-HSA-9694516 | SARS-CoV-2 Infection | 2.529657e-01 | 0.597 |
R-HSA-72649 | Translation initiation complex formation | 2.541129e-01 | 0.595 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.541129e-01 | 0.595 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 2.541129e-01 | 0.595 |
R-HSA-3214815 | HDACs deacetylate histones | 2.576386e-01 | 0.589 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.576386e-01 | 0.589 |
R-HSA-9012852 | Signaling by NOTCH3 | 2.576386e-01 | 0.589 |
R-HSA-168898 | Toll-like Receptor Cascades | 2.609474e-01 | 0.583 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.611478e-01 | 0.583 |
R-HSA-5578775 | Ion homeostasis | 2.611478e-01 | 0.583 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.611478e-01 | 0.583 |
R-HSA-75893 | TNF signaling | 2.611478e-01 | 0.583 |
R-HSA-68877 | Mitotic Prometaphase | 2.644427e-01 | 0.578 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.681172e-01 | 0.572 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.681172e-01 | 0.572 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.696863e-01 | 0.569 |
R-HSA-8979227 | Triglyceride metabolism | 2.715775e-01 | 0.566 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.750217e-01 | 0.561 |
R-HSA-8873719 | RAB geranylgeranylation | 2.750217e-01 | 0.561 |
R-HSA-983189 | Kinesins | 2.750217e-01 | 0.561 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 2.750217e-01 | 0.561 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.750217e-01 | 0.561 |
R-HSA-450294 | MAP kinase activation | 2.784498e-01 | 0.555 |
R-HSA-112043 | PLC beta mediated events | 2.784498e-01 | 0.555 |
R-HSA-1268020 | Mitochondrial protein import | 2.818619e-01 | 0.550 |
R-HSA-373755 | Semaphorin interactions | 2.852581e-01 | 0.545 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.920030e-01 | 0.535 |
R-HSA-9824446 | Viral Infection Pathways | 2.976566e-01 | 0.526 |
R-HSA-112040 | G-protein mediated events | 2.986850e-01 | 0.525 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.085916e-01 | 0.511 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.085916e-01 | 0.511 |
R-HSA-204005 | COPII-mediated vesicle transport | 3.085916e-01 | 0.511 |
R-HSA-448424 | Interleukin-17 signaling | 3.085916e-01 | 0.511 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.085916e-01 | 0.511 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.085916e-01 | 0.511 |
R-HSA-418990 | Adherens junctions interactions | 3.098117e-01 | 0.509 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.118630e-01 | 0.506 |
R-HSA-189445 | Metabolism of porphyrins | 3.118630e-01 | 0.506 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.151192e-01 | 0.502 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.151192e-01 | 0.502 |
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 3.151192e-01 | 0.502 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.183601e-01 | 0.497 |
R-HSA-1266738 | Developmental Biology | 3.226612e-01 | 0.491 |
R-HSA-212436 | Generic Transcription Pathway | 3.233410e-01 | 0.490 |
R-HSA-8852135 | Protein ubiquitination | 3.247966e-01 | 0.488 |
R-HSA-917937 | Iron uptake and transport | 3.247966e-01 | 0.488 |
R-HSA-109582 | Hemostasis | 3.309606e-01 | 0.480 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.343390e-01 | 0.476 |
R-HSA-3247509 | Chromatin modifying enzymes | 3.374998e-01 | 0.472 |
R-HSA-9833482 | PKR-mediated signaling | 3.406266e-01 | 0.468 |
R-HSA-977225 | Amyloid fiber formation | 3.437484e-01 | 0.464 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 3.499483e-01 | 0.456 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.530265e-01 | 0.452 |
R-HSA-6802957 | Oncogenic MAPK signaling | 3.560903e-01 | 0.448 |
R-HSA-1500620 | Meiosis | 3.560903e-01 | 0.448 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.560903e-01 | 0.448 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.591398e-01 | 0.445 |
R-HSA-141424 | Amplification of signal from the kinetochores | 3.591398e-01 | 0.445 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.591398e-01 | 0.445 |
R-HSA-5619115 | Disorders of transmembrane transporters | 3.597647e-01 | 0.444 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.621751e-01 | 0.441 |
R-HSA-162582 | Signal Transduction | 3.624889e-01 | 0.441 |
R-HSA-4839726 | Chromatin organization | 3.631676e-01 | 0.440 |
R-HSA-70268 | Pyruvate metabolism | 3.651961e-01 | 0.437 |
R-HSA-390466 | Chaperonin-mediated protein folding | 3.651961e-01 | 0.437 |
R-HSA-421270 | Cell-cell junction organization | 3.665641e-01 | 0.436 |
R-HSA-156902 | Peptide chain elongation | 3.682031e-01 | 0.434 |
R-HSA-5688426 | Deubiquitination | 3.733369e-01 | 0.428 |
R-HSA-73884 | Base Excision Repair | 3.741749e-01 | 0.427 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.771399e-01 | 0.423 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.800910e-01 | 0.420 |
R-HSA-156842 | Eukaryotic Translation Elongation | 3.830283e-01 | 0.417 |
R-HSA-391251 | Protein folding | 3.830283e-01 | 0.417 |
R-HSA-68867 | Assembly of the pre-replicative complex | 3.859519e-01 | 0.413 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.859519e-01 | 0.413 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.917581e-01 | 0.407 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.917581e-01 | 0.407 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 3.946408e-01 | 0.404 |
R-HSA-72764 | Eukaryotic Translation Termination | 3.946408e-01 | 0.404 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.946408e-01 | 0.404 |
R-HSA-9711123 | Cellular response to chemical stress | 3.951477e-01 | 0.403 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.975101e-01 | 0.401 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.975101e-01 | 0.401 |
R-HSA-157579 | Telomere Maintenance | 4.003659e-01 | 0.398 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.003659e-01 | 0.398 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.032084e-01 | 0.394 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.032084e-01 | 0.394 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.032084e-01 | 0.394 |
R-HSA-422356 | Regulation of insulin secretion | 4.032084e-01 | 0.394 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.034838e-01 | 0.394 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 4.051022e-01 | 0.392 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 4.088535e-01 | 0.388 |
R-HSA-2408557 | Selenocysteine synthesis | 4.116563e-01 | 0.385 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.116563e-01 | 0.385 |
R-HSA-446728 | Cell junction organization | 4.116964e-01 | 0.385 |
R-HSA-9842860 | Regulation of endogenous retroelements | 4.144460e-01 | 0.383 |
R-HSA-9658195 | Leishmania infection | 4.166193e-01 | 0.380 |
R-HSA-9824443 | Parasitic Infection Pathways | 4.166193e-01 | 0.380 |
R-HSA-192823 | Viral mRNA Translation | 4.172226e-01 | 0.380 |
R-HSA-5663205 | Infectious disease | 4.191157e-01 | 0.378 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.199862e-01 | 0.377 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.199862e-01 | 0.377 |
R-HSA-111885 | Opioid Signalling | 4.199862e-01 | 0.377 |
R-HSA-9833110 | RSV-host interactions | 4.227369e-01 | 0.374 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 4.281996e-01 | 0.368 |
R-HSA-5673001 | RAF/MAP kinase cascade | 4.296478e-01 | 0.367 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.309119e-01 | 0.366 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.309119e-01 | 0.366 |
R-HSA-9700206 | Signaling by ALK in cancer | 4.309119e-01 | 0.366 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.336114e-01 | 0.363 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.336114e-01 | 0.363 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.336114e-01 | 0.363 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.362983e-01 | 0.360 |
R-HSA-69002 | DNA Replication Pre-Initiation | 4.362983e-01 | 0.360 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.409248e-01 | 0.356 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.442838e-01 | 0.352 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.442838e-01 | 0.352 |
R-HSA-2871796 | FCERI mediated MAPK activation | 4.442838e-01 | 0.352 |
R-HSA-72737 | Cap-dependent Translation Initiation | 4.599212e-01 | 0.337 |
R-HSA-72613 | Eukaryotic Translation Initiation | 4.599212e-01 | 0.337 |
R-HSA-373760 | L1CAM interactions | 4.599212e-01 | 0.337 |
R-HSA-1592230 | Mitochondrial biogenesis | 4.624849e-01 | 0.335 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.660690e-01 | 0.332 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.675763e-01 | 0.330 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.675763e-01 | 0.330 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.726201e-01 | 0.325 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.751243e-01 | 0.323 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.751243e-01 | 0.323 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.776168e-01 | 0.321 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.776168e-01 | 0.321 |
R-HSA-2132295 | MHC class II antigen presentation | 4.776168e-01 | 0.321 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 4.786564e-01 | 0.320 |
R-HSA-114608 | Platelet degranulation | 4.899049e-01 | 0.310 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.971404e-01 | 0.304 |
R-HSA-1474165 | Reproduction | 4.995296e-01 | 0.301 |
R-HSA-9843745 | Adipogenesis | 5.019077e-01 | 0.299 |
R-HSA-5576891 | Cardiac conduction | 5.019077e-01 | 0.299 |
R-HSA-9909396 | Circadian clock | 5.042746e-01 | 0.297 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.066304e-01 | 0.295 |
R-HSA-9679506 | SARS-CoV Infections | 5.140877e-01 | 0.289 |
R-HSA-163685 | Integration of energy metabolism | 5.159436e-01 | 0.287 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.250833e-01 | 0.280 |
R-HSA-9664417 | Leishmania phagocytosis | 5.250833e-01 | 0.280 |
R-HSA-9664407 | Parasite infection | 5.250833e-01 | 0.280 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.273414e-01 | 0.278 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 5.428547e-01 | 0.265 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.514927e-01 | 0.258 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.536269e-01 | 0.257 |
R-HSA-69306 | DNA Replication | 5.557511e-01 | 0.255 |
R-HSA-9609507 | Protein localization | 5.557511e-01 | 0.255 |
R-HSA-73887 | Death Receptor Signaling | 5.578653e-01 | 0.253 |
R-HSA-1989781 | PPARA activates gene expression | 5.599696e-01 | 0.252 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.641485e-01 | 0.249 |
R-HSA-9711097 | Cellular response to starvation | 5.662233e-01 | 0.247 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.662233e-01 | 0.247 |
R-HSA-877300 | Interferon gamma signaling | 5.682883e-01 | 0.245 |
R-HSA-9006936 | Signaling by TGFB family members | 5.703436e-01 | 0.244 |
R-HSA-556833 | Metabolism of lipids | 5.764207e-01 | 0.239 |
R-HSA-2467813 | Separation of Sister Chromatids | 5.784688e-01 | 0.238 |
R-HSA-2408522 | Selenoamino acid metabolism | 5.784688e-01 | 0.238 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.923245e-01 | 0.227 |
R-HSA-449147 | Signaling by Interleukins | 5.924068e-01 | 0.227 |
R-HSA-5689880 | Ub-specific processing proteases | 5.981242e-01 | 0.223 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.019453e-01 | 0.220 |
R-HSA-9678108 | SARS-CoV-1 Infection | 6.019453e-01 | 0.220 |
R-HSA-8978868 | Fatty acid metabolism | 6.030608e-01 | 0.220 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.259233e-01 | 0.203 |
R-HSA-5617833 | Cilium Assembly | 6.294835e-01 | 0.201 |
R-HSA-72766 | Translation | 6.305175e-01 | 0.200 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.501529e-01 | 0.187 |
R-HSA-376176 | Signaling by ROBO receptors | 6.518231e-01 | 0.186 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.518231e-01 | 0.186 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.610704e-01 | 0.180 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.696836e-01 | 0.174 |
R-HSA-597592 | Post-translational protein modification | 6.911469e-01 | 0.160 |
R-HSA-72312 | rRNA processing | 6.984285e-01 | 0.156 |
R-HSA-15869 | Metabolism of nucleotides | 7.041578e-01 | 0.152 |
R-HSA-1643685 | Disease | 7.155846e-01 | 0.145 |
R-HSA-392499 | Metabolism of proteins | 7.282203e-01 | 0.138 |
R-HSA-9734767 | Developmental Cell Lineages | 7.401180e-01 | 0.131 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.628019e-01 | 0.118 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.215006e-01 | 0.085 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.550044e-01 | 0.068 |
R-HSA-418594 | G alpha (i) signalling events | 8.709204e-01 | 0.060 |
R-HSA-1430728 | Metabolism | 8.782069e-01 | 0.056 |
R-HSA-446203 | Asparagine N-linked glycosylation | 8.799790e-01 | 0.056 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.539167e-01 | 0.020 |
R-HSA-388396 | GPCR downstream signalling | 9.786751e-01 | 0.009 |
R-HSA-372790 | Signaling by GPCR | 9.858929e-01 | 0.006 |
R-HSA-382551 | Transport of small molecules | 9.924226e-01 | 0.003 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
BMPR1B |
0.602 | 0.166 | 1 | 0.783 |
BMPR1A |
0.595 | 0.165 | 1 | 0.765 |
CDC7 |
0.595 | 0.143 | 1 | 0.773 |
ALK2 |
0.592 | 0.175 | -2 | 0.500 |
ACVR2B |
0.592 | 0.130 | -2 | 0.500 |
TGFBR1 |
0.591 | 0.117 | -2 | 0.500 |
ERK5 |
0.589 | 0.159 | 1 | 0.714 |
CLK3 |
0.588 | 0.019 | 1 | 0.684 |
MAPKAPK2 |
0.588 | 0.035 | -3 | 0.500 |
RSK2 |
0.588 | 0.022 | -3 | 0.500 |
ACVR2A |
0.587 | 0.112 | -2 | 0.500 |
CLK2 |
0.587 | 0.055 | -3 | 0.500 |
CAMK2D |
0.585 | 0.058 | -3 | 0.500 |
GRK1 |
0.585 | 0.036 | -2 | 0.500 |
GRK5 |
0.585 | 0.041 | -3 | 0.500 |
MOS |
0.585 | 0.029 | 1 | 0.739 |
DSTYK |
0.585 | 0.017 | 2 | 0.716 |
MSK1 |
0.585 | 0.026 | -3 | 0.500 |
IKKB |
0.584 | 0.022 | -2 | 0.500 |
GRK6 |
0.584 | 0.084 | 1 | 0.701 |
MAPKAPK3 |
0.583 | 0.022 | -3 | 0.500 |
PKACB |
0.582 | -0.000 | -2 | 0.500 |
PIM3 |
0.582 | -0.012 | -3 | 0.500 |
CAMK2B |
0.582 | 0.065 | 2 | 0.647 |
PDHK4 |
0.582 | 0.019 | 1 | 0.635 |
LATS2 |
0.581 | -0.004 | -5 | 0.500 |
SBK |
0.581 | 0.018 | -3 | 0.500 |
NDR2 |
0.581 | -0.011 | -3 | 0.500 |
COT |
0.581 | -0.020 | 2 | 0.640 |
P90RSK |
0.581 | 0.005 | -3 | 0.500 |
MTOR |
0.581 | 0.007 | 1 | 0.612 |
GRK3 |
0.581 | 0.045 | -2 | 0.500 |
PRKD1 |
0.581 | 0.001 | -3 | 0.500 |
PRPK |
0.581 | -0.004 | -1 | 0.124 |
CAMK2A |
0.581 | 0.026 | 2 | 0.672 |
PRKX |
0.580 | -0.010 | -3 | 0.500 |
ALK4 |
0.580 | 0.106 | -2 | 0.500 |
CAMK2G |
0.580 | 0.032 | 2 | 0.651 |
PKACA |
0.580 | 0.004 | -2 | 0.500 |
CK1D |
0.580 | -0.005 | -3 | 0.500 |
CDKL5 |
0.580 | 0.026 | -3 | 0.500 |
CLK4 |
0.580 | 0.022 | -3 | 0.500 |
SKMLCK |
0.580 | 0.034 | -2 | 0.500 |
RSK4 |
0.580 | 0.006 | -3 | 0.500 |
SMG1 |
0.580 | 0.107 | 1 | 0.551 |
BMPR2 |
0.579 | 0.097 | -2 | 0.500 |
RSK3 |
0.579 | -0.003 | -3 | 0.500 |
GRK2 |
0.579 | 0.051 | -2 | 0.500 |
GRK4 |
0.579 | -0.002 | -2 | 0.500 |
PAK6 |
0.579 | 0.050 | -2 | 0.500 |
CDKL1 |
0.579 | 0.013 | -3 | 0.500 |
IKKA |
0.579 | 0.007 | -2 | 0.500 |
AURA |
0.579 | 0.014 | -2 | 0.500 |
MAPKAPK5 |
0.578 | 0.041 | -3 | 0.500 |
MSK2 |
0.578 | -0.002 | -3 | 0.500 |
AURC |
0.578 | -0.015 | -2 | 0.500 |
SRPK1 |
0.577 | 0.011 | -3 | 0.500 |
PIM1 |
0.577 | -0.015 | -3 | 0.500 |
FAM20C |
0.576 | 0.082 | 2 | 0.617 |
PRKD2 |
0.576 | -0.018 | -3 | 0.500 |
SRPK2 |
0.576 | 0.002 | -3 | 0.500 |
CK1E |
0.576 | -0.016 | -3 | 0.500 |
RAF1 |
0.575 | -0.017 | 1 | 0.617 |
CAMK1B |
0.575 | -0.030 | -3 | 0.500 |
CLK1 |
0.575 | 0.013 | -3 | 0.500 |
CK2A2 |
0.575 | 0.101 | 1 | 0.720 |
TGFBR2 |
0.575 | 0.009 | -2 | 0.500 |
MYLK4 |
0.574 | 0.009 | -2 | 0.500 |
ATR |
0.574 | -0.015 | 1 | 0.611 |
P70S6KB |
0.574 | -0.024 | -3 | 0.500 |
PKACG |
0.574 | -0.024 | -2 | 0.500 |
CDK8 |
0.574 | 0.051 | 1 | 0.539 |
CAMLCK |
0.574 | 0.022 | -2 | 0.500 |
SRPK3 |
0.574 | 0.016 | -3 | 0.500 |
ICK |
0.573 | 0.009 | -3 | 0.500 |
DAPK2 |
0.573 | 0.009 | -3 | 0.500 |
P38B |
0.573 | 0.087 | 1 | 0.566 |
ATM |
0.573 | 0.006 | 1 | 0.569 |
HIPK4 |
0.573 | -0.005 | 1 | 0.589 |
DYRK2 |
0.573 | 0.039 | 1 | 0.550 |
CHK1 |
0.572 | -0.014 | -3 | 0.500 |
CDK19 |
0.572 | 0.057 | 1 | 0.507 |
AKT2 |
0.572 | -0.012 | -3 | 0.500 |
GRK7 |
0.571 | -0.001 | 1 | 0.664 |
CK1A2 |
0.571 | -0.015 | -3 | 0.500 |
LATS1 |
0.571 | -0.004 | -3 | 0.500 |
NDR1 |
0.571 | -0.051 | -3 | 0.500 |
PIM2 |
0.571 | -0.012 | -3 | 0.500 |
MASTL |
0.571 | 0.002 | -2 | 0.500 |
PDHK1 |
0.570 | -0.089 | 1 | 0.597 |
KIS |
0.570 | 0.028 | 1 | 0.555 |
NLK |
0.570 | 0.025 | 1 | 0.636 |
JNK2 |
0.570 | 0.079 | 1 | 0.513 |
DYRK4 |
0.570 | 0.056 | 1 | 0.511 |
PRKD3 |
0.570 | -0.025 | -3 | 0.500 |
IKKE |
0.570 | -0.012 | 1 | 0.500 |
NUAK2 |
0.569 | -0.032 | -3 | 0.500 |
CK2A1 |
0.569 | 0.095 | 1 | 0.708 |
AURB |
0.569 | -0.021 | -2 | 0.500 |
CDK13 |
0.569 | 0.063 | 1 | 0.530 |
PKG2 |
0.569 | -0.013 | -2 | 0.500 |
JNK3 |
0.569 | 0.064 | 1 | 0.549 |
CK1A |
0.569 | -0.008 | -3 | 0.500 |
DRAK1 |
0.568 | 0.075 | 1 | 0.666 |
P38A |
0.568 | 0.070 | 1 | 0.588 |
PLK1 |
0.568 | 0.028 | -2 | 0.500 |
CHAK2 |
0.568 | -0.038 | -1 | 0.091 |
PRP4 |
0.568 | 0.028 | -3 | 0.500 |
PAK4 |
0.568 | 0.037 | -2 | 0.500 |
DNAPK |
0.567 | 0.030 | 1 | 0.474 |
PAK5 |
0.567 | 0.019 | -2 | 0.500 |
TBK1 |
0.567 | -0.026 | 1 | 0.499 |
NIK |
0.566 | -0.056 | -3 | 0.500 |
HUNK |
0.566 | -0.033 | 2 | 0.634 |
CDK7 |
0.566 | 0.020 | 1 | 0.553 |
PLK3 |
0.566 | 0.004 | 2 | 0.620 |
BCKDK |
0.566 | -0.094 | -1 | 0.090 |
NEK6 |
0.565 | -0.079 | -2 | 0.500 |
GCN2 |
0.565 | -0.071 | 2 | 0.581 |
NEK7 |
0.565 | -0.083 | -3 | 0.500 |
DYRK3 |
0.565 | 0.018 | 1 | 0.536 |
CDK9 |
0.565 | 0.061 | 1 | 0.529 |
DLK |
0.564 | -0.023 | 1 | 0.639 |
WNK1 |
0.564 | -0.051 | -2 | 0.500 |
CAMK4 |
0.564 | -0.049 | -3 | 0.500 |
PKN3 |
0.564 | -0.052 | -3 | 0.500 |
P38D |
0.564 | 0.072 | 1 | 0.463 |
CDK12 |
0.564 | 0.057 | 1 | 0.508 |
PAK1 |
0.564 | -0.031 | -2 | 0.500 |
P70S6K |
0.563 | -0.025 | -3 | 0.500 |
PASK |
0.563 | 0.020 | -3 | 0.500 |
AKT3 |
0.563 | -0.011 | -3 | 0.500 |
MLK1 |
0.563 | -0.033 | 2 | 0.603 |
SGK3 |
0.563 | -0.022 | -3 | 0.500 |
ERK1 |
0.563 | 0.047 | 1 | 0.536 |
SGK1 |
0.563 | -0.012 | -3 | 0.500 |
MAK |
0.562 | 0.026 | -2 | 0.500 |
NEK9 |
0.562 | 0.001 | 2 | 0.596 |
CAMK1D |
0.562 | -0.032 | -3 | 0.500 |
PAK3 |
0.562 | -0.031 | -2 | 0.500 |
DYRK1A |
0.562 | 0.012 | 1 | 0.572 |
MARK4 |
0.561 | -0.073 | 4 | 0.536 |
MEK1 |
0.561 | 0.003 | 2 | 0.633 |
ULK1 |
0.561 | -0.048 | -3 | 0.500 |
AMPKA1 |
0.561 | -0.056 | -3 | 0.500 |
ULK2 |
0.561 | -0.088 | 2 | 0.541 |
TTBK2 |
0.560 | -0.033 | 2 | 0.516 |
AMPKA2 |
0.560 | -0.050 | -3 | 0.500 |
HIPK1 |
0.560 | 0.007 | 1 | 0.551 |
DYRK1B |
0.560 | 0.016 | 1 | 0.511 |
MNK2 |
0.560 | -0.049 | -2 | 0.500 |
RIPK3 |
0.560 | -0.046 | 3 | 0.705 |
PINK1 |
0.560 | -0.025 | 1 | 0.582 |
DAPK1 |
0.560 | 0.012 | -3 | 0.500 |
TSSK2 |
0.560 | -0.060 | -5 | 0.500 |
MLK2 |
0.560 | -0.040 | 2 | 0.594 |
SMMLCK |
0.559 | -0.003 | -3 | 0.500 |
PAK2 |
0.559 | -0.030 | -2 | 0.500 |
NEK2 |
0.559 | 0.001 | 2 | 0.587 |
BRAF |
0.559 | 0.028 | -4 | 0.500 |
P38G |
0.559 | 0.044 | 1 | 0.474 |
YSK4 |
0.559 | -0.042 | 1 | 0.558 |
HIPK2 |
0.558 | 0.007 | 1 | 0.483 |
PKN2 |
0.558 | -0.067 | -3 | 0.500 |
WNK3 |
0.558 | -0.052 | 1 | 0.556 |
AKT1 |
0.558 | -0.025 | -3 | 0.500 |
CK1G1 |
0.557 | -0.041 | -3 | 0.500 |
MST4 |
0.557 | -0.091 | 2 | 0.637 |
CDK18 |
0.557 | 0.014 | 1 | 0.500 |
DAPK3 |
0.556 | -0.007 | -3 | 0.500 |
HIPK3 |
0.556 | 0.012 | 1 | 0.533 |
CHK2 |
0.556 | -0.020 | -3 | 0.500 |
RIPK1 |
0.556 | -0.067 | 1 | 0.545 |
CDK1 |
0.556 | 0.013 | 1 | 0.546 |
PLK2 |
0.556 | -0.008 | -3 | 0.500 |
PKG1 |
0.556 | -0.010 | -2 | 0.500 |
TLK2 |
0.556 | -0.060 | 1 | 0.539 |
MLK3 |
0.556 | -0.016 | 2 | 0.549 |
MELK |
0.556 | -0.053 | -3 | 0.500 |
ERK2 |
0.556 | 0.031 | 1 | 0.559 |
JNK1 |
0.555 | 0.052 | 1 | 0.525 |
CAMKK1 |
0.555 | 0.022 | -2 | 0.500 |
MRCKB |
0.555 | -0.019 | -3 | 0.500 |
SIK |
0.555 | -0.071 | -3 | 0.500 |
MOK |
0.554 | 0.022 | 1 | 0.583 |
ANKRD3 |
0.554 | -0.128 | 1 | 0.597 |
LKB1 |
0.554 | 0.039 | -3 | 0.500 |
BRSK1 |
0.554 | -0.041 | -3 | 0.500 |
NIM1 |
0.554 | -0.069 | 3 | 0.695 |
DCAMKL1 |
0.553 | -0.062 | -3 | 0.500 |
NUAK1 |
0.553 | -0.076 | -3 | 0.500 |
QIK |
0.553 | -0.084 | -3 | 0.500 |
CAMK1A |
0.553 | -0.038 | -3 | 0.500 |
QSK |
0.553 | -0.069 | 4 | 0.510 |
MNK1 |
0.553 | -0.077 | -2 | 0.500 |
PERK |
0.552 | -0.034 | -2 | 0.500 |
TSSK1 |
0.552 | -0.080 | -3 | 0.500 |
PKCD |
0.552 | -0.069 | 2 | 0.554 |
CDK14 |
0.552 | 0.029 | 1 | 0.512 |
CAMKK2 |
0.551 | 0.002 | -2 | 0.500 |
CDK17 |
0.550 | 0.015 | 1 | 0.472 |
CAMK1G |
0.550 | -0.076 | -3 | 0.500 |
CDK10 |
0.550 | 0.012 | 1 | 0.500 |
MRCKA |
0.550 | -0.036 | -3 | 0.500 |
PHKG1 |
0.549 | -0.057 | -3 | 0.500 |
VRK2 |
0.549 | -0.120 | 1 | 0.631 |
PKCG |
0.549 | -0.074 | 2 | 0.539 |
MLK4 |
0.548 | -0.072 | 2 | 0.512 |
MARK3 |
0.548 | -0.067 | 4 | 0.462 |
CDK5 |
0.548 | 0.006 | 1 | 0.562 |
MEKK3 |
0.547 | -0.074 | 1 | 0.572 |
MARK2 |
0.547 | -0.060 | 4 | 0.445 |
PKCB |
0.547 | -0.069 | 2 | 0.528 |
MARK1 |
0.547 | -0.058 | 4 | 0.475 |
PKR |
0.547 | -0.068 | 1 | 0.562 |
ERK7 |
0.547 | 0.019 | 2 | 0.382 |
TLK1 |
0.547 | -0.108 | -2 | 0.500 |
CK1G3 |
0.547 | -0.025 | -3 | 0.500 |
HRI |
0.547 | -0.084 | -2 | 0.500 |
CRIK |
0.546 | -0.027 | -3 | 0.500 |
SNRK |
0.546 | -0.065 | 2 | 0.489 |
PKCA |
0.545 | -0.067 | 2 | 0.517 |
GSK3B |
0.545 | -0.014 | 4 | 0.337 |
WNK4 |
0.545 | -0.024 | -2 | 0.500 |
CHAK1 |
0.545 | -0.091 | 2 | 0.575 |
DCAMKL2 |
0.545 | -0.068 | -3 | 0.500 |
TTBK1 |
0.544 | -0.058 | 2 | 0.453 |
BRSK2 |
0.544 | -0.077 | -3 | 0.500 |
TAK1 |
0.544 | 0.050 | 1 | 0.598 |
NEK5 |
0.544 | -0.037 | 1 | 0.559 |
PKN1 |
0.544 | -0.040 | -3 | 0.500 |
PKCZ |
0.543 | -0.098 | 2 | 0.547 |
ZAK |
0.543 | -0.069 | 1 | 0.566 |
PKCH |
0.543 | -0.076 | 2 | 0.509 |
PLK4 |
0.543 | -0.047 | 2 | 0.439 |
GSK3A |
0.543 | -0.027 | 4 | 0.349 |
CDK16 |
0.543 | -0.003 | 1 | 0.483 |
MEK5 |
0.543 | -0.105 | 2 | 0.603 |
MEKK1 |
0.543 | -0.058 | 1 | 0.543 |
CDK2 |
0.542 | -0.020 | 1 | 0.597 |
MST3 |
0.542 | -0.059 | 2 | 0.650 |
MPSK1 |
0.542 | -0.047 | 1 | 0.518 |
PDK1 |
0.542 | -0.010 | 1 | 0.560 |
DMPK1 |
0.542 | -0.035 | -3 | 0.500 |
HPK1 |
0.541 | 0.013 | 1 | 0.543 |
ROCK2 |
0.541 | -0.046 | -3 | 0.500 |
GAK |
0.541 | -0.034 | 1 | 0.613 |
TAO3 |
0.541 | -0.081 | 1 | 0.572 |
NEK11 |
0.540 | -0.028 | 1 | 0.564 |
IRAK1 |
0.540 | -0.093 | -1 | 0.142 |
CDK3 |
0.540 | 0.007 | 1 | 0.493 |
PKCI |
0.540 | -0.060 | 2 | 0.518 |
NEK8 |
0.540 | -0.041 | 2 | 0.594 |
SLK |
0.539 | -0.048 | -2 | 0.500 |
BUB1 |
0.539 | -0.012 | -5 | 0.500 |
GCK |
0.538 | -0.016 | 1 | 0.563 |
TAO2 |
0.538 | -0.033 | 2 | 0.622 |
CDK4 |
0.537 | 0.030 | 1 | 0.493 |
IRE1 |
0.537 | -0.125 | 1 | 0.516 |
MEKK2 |
0.537 | -0.081 | 2 | 0.565 |
RIPK2 |
0.537 | -0.028 | 1 | 0.505 |
PKCE |
0.537 | -0.061 | 2 | 0.530 |
MEK2 |
0.536 | -0.021 | 2 | 0.579 |
ROCK1 |
0.536 | -0.036 | -3 | 0.500 |
PBK |
0.536 | -0.014 | 1 | 0.530 |
PHKG2 |
0.536 | -0.086 | -3 | 0.500 |
PKCT |
0.536 | -0.084 | 2 | 0.502 |
LOK |
0.535 | -0.038 | -2 | 0.500 |
MST2 |
0.535 | -0.083 | 1 | 0.570 |
CK1G2 |
0.535 | -0.055 | -3 | 0.500 |
NEK4 |
0.534 | -0.027 | 1 | 0.498 |
CDK6 |
0.533 | 0.018 | 1 | 0.490 |
EEF2K |
0.533 | -0.020 | 3 | 0.715 |
NEK1 |
0.533 | 0.009 | 1 | 0.525 |
SSTK |
0.533 | -0.103 | 4 | 0.489 |
MEKK6 |
0.532 | -0.057 | 1 | 0.589 |
LRRK2 |
0.532 | -0.079 | 2 | 0.630 |
NEK3 |
0.532 | -0.002 | 1 | 0.502 |
TNIK |
0.532 | -0.021 | 3 | 0.749 |
IRE2 |
0.531 | -0.112 | 2 | 0.479 |
HGK |
0.531 | -0.035 | 3 | 0.751 |
IRAK4 |
0.530 | -0.110 | 1 | 0.511 |
MINK |
0.529 | -0.041 | 1 | 0.527 |
STK33 |
0.529 | -0.065 | 2 | 0.450 |
MAP3K15 |
0.527 | -0.099 | 1 | 0.550 |
ALPHAK3 |
0.527 | -0.032 | -1 | 0.099 |
KHS2 |
0.526 | -0.021 | 1 | 0.528 |
KHS1 |
0.526 | -0.038 | 1 | 0.513 |
MST1 |
0.524 | -0.102 | 1 | 0.535 |
VRK1 |
0.522 | -0.095 | 2 | 0.588 |
YSK1 |
0.521 | -0.061 | 2 | 0.581 |
BIKE |
0.521 | -0.010 | 1 | 0.489 |
OSR1 |
0.518 | -0.079 | 2 | 0.551 |
YANK3 |
0.518 | -0.044 | 2 | 0.299 |
HASPIN |
0.516 | -0.088 | -1 | 0.075 |
ASK1 |
0.516 | -0.068 | 1 | 0.553 |
TAO1 |
0.514 | -0.042 | 1 | 0.481 |
MYO3B |
0.513 | -0.028 | 2 | 0.597 |
TTK |
0.513 | -0.084 | -2 | 0.500 |
AAK1 |
0.510 | -0.017 | 1 | 0.404 |
MYO3A |
0.507 | -0.063 | 1 | 0.483 |
STLK3 |
0.504 | -0.087 | 1 | 0.515 |
TXK |
0.504 | 0.133 | 1 | 0.748 |
YANK2 |
0.501 | -0.052 | 2 | 0.308 |
SRMS |
0.501 | 0.137 | 1 | 0.731 |
MAP2K4_TYR |
0.500 | 0.084 | -1 | 0.136 |
MAP2K6_TYR |
0.499 | 0.042 | -1 | 0.114 |
PDHK3_TYR |
0.498 | 0.024 | 4 | 0.654 |
EPHA4 |
0.495 | 0.051 | 2 | 0.648 |
BMPR2_TYR |
0.495 | -0.014 | -1 | 0.097 |
PDHK1_TYR |
0.494 | -0.021 | -1 | 0.103 |
FER |
0.493 | 0.060 | 1 | 0.733 |
EPHB4 |
0.492 | 0.020 | -1 | 0.103 |
PDHK4_TYR |
0.492 | -0.032 | 2 | 0.687 |
EPHB3 |
0.491 | 0.039 | -1 | 0.109 |
SYK |
0.491 | 0.012 | -1 | 0.071 |
EPHA6 |
0.491 | -0.011 | -1 | 0.090 |
EPHB1 |
0.490 | 0.041 | 1 | 0.719 |
BMX |
0.490 | 0.033 | -1 | 0.116 |
MAP2K7_TYR |
0.490 | -0.083 | 2 | 0.669 |
EPHB2 |
0.489 | 0.021 | -1 | 0.098 |
TESK1_TYR |
0.489 | -0.079 | 3 | 0.770 |
MERTK |
0.488 | 0.061 | 3 | 0.731 |
EPHA5 |
0.488 | 0.036 | 2 | 0.634 |
ITK |
0.488 | 0.051 | -1 | 0.141 |
PTK2 |
0.487 | 0.015 | -1 | 0.065 |
TEC |
0.487 | 0.040 | -1 | 0.151 |
TNK2 |
0.486 | 0.066 | 3 | 0.714 |
EPHA7 |
0.485 | 0.021 | 2 | 0.624 |
PTK2B |
0.485 | 0.037 | -1 | 0.113 |
BLK |
0.485 | 0.015 | -1 | 0.118 |
LIMK2_TYR |
0.485 | -0.052 | -3 | 0.500 |
ABL2 |
0.485 | 0.010 | -1 | 0.125 |
BTK |
0.485 | 0.045 | -1 | 0.178 |
HCK |
0.484 | -0.007 | -1 | 0.130 |
PINK1_TYR |
0.484 | -0.127 | 1 | 0.648 |
YES1 |
0.484 | -0.005 | -1 | 0.131 |
PKMYT1_TYR |
0.484 | -0.139 | 3 | 0.766 |
FYN |
0.483 | -0.014 | -1 | 0.091 |
FGR |
0.482 | -0.042 | 1 | 0.663 |
LCK |
0.482 | -0.029 | -1 | 0.105 |
DDR1 |
0.482 | -0.060 | 4 | 0.563 |
ABL1 |
0.482 | 0.001 | -1 | 0.130 |
EPHA3 |
0.482 | -0.018 | 2 | 0.610 |
MATK |
0.481 | -0.023 | -1 | 0.102 |
AXL |
0.481 | 0.014 | 3 | 0.727 |
EPHA8 |
0.481 | -0.017 | -1 | 0.084 |
TYRO3 |
0.480 | -0.024 | 3 | 0.717 |
NTRK1 |
0.480 | -0.023 | -1 | 0.107 |
EPHA2 |
0.480 | 0.001 | -1 | 0.080 |
NTRK3 |
0.479 | -0.029 | -1 | 0.086 |
INSRR |
0.479 | -0.046 | 3 | 0.687 |
LYN |
0.479 | -0.022 | 3 | 0.680 |
TEK |
0.478 | 0.030 | 3 | 0.672 |
KIT |
0.478 | -0.065 | 3 | 0.738 |
EPHA1 |
0.477 | -0.001 | 3 | 0.734 |
CSF1R |
0.477 | -0.067 | 3 | 0.742 |
LIMK1_TYR |
0.476 | -0.162 | 2 | 0.631 |
FLT1 |
0.476 | -0.091 | -1 | 0.074 |
RET |
0.476 | -0.140 | 1 | 0.578 |
FGFR2 |
0.475 | -0.087 | 3 | 0.730 |
CSK |
0.475 | -0.038 | 2 | 0.618 |
SRC |
0.475 | -0.037 | -1 | 0.098 |
FRK |
0.474 | -0.027 | -1 | 0.135 |
MST1R |
0.474 | -0.126 | 3 | 0.751 |
FGFR4 |
0.473 | -0.040 | -1 | 0.093 |
JAK2 |
0.473 | -0.115 | 1 | 0.581 |
EGFR |
0.473 | -0.041 | 1 | 0.551 |
FGFR3 |
0.473 | -0.065 | 3 | 0.710 |
ZAP70 |
0.472 | -0.037 | -1 | 0.052 |
JAK3 |
0.472 | -0.139 | 1 | 0.604 |
TYK2 |
0.472 | -0.128 | 1 | 0.572 |
MET |
0.472 | -0.085 | 3 | 0.728 |
ROS1 |
0.471 | -0.088 | 3 | 0.707 |
ERBB2 |
0.471 | -0.072 | 1 | 0.594 |
LTK |
0.470 | -0.045 | 3 | 0.688 |
PTK6 |
0.470 | -0.107 | -1 | 0.101 |
NTRK2 |
0.469 | -0.073 | 3 | 0.698 |
ERBB4 |
0.468 | -0.025 | 1 | 0.595 |
FLT3 |
0.468 | -0.089 | 3 | 0.731 |
NEK10_TYR |
0.468 | -0.070 | 1 | 0.508 |
FES |
0.468 | -0.012 | -1 | 0.105 |
WEE1_TYR |
0.467 | -0.070 | -1 | 0.122 |
FGFR1 |
0.467 | -0.113 | 3 | 0.711 |
KDR |
0.466 | -0.124 | 3 | 0.720 |
PDGFRB |
0.465 | -0.120 | 3 | 0.735 |
TNK1 |
0.465 | -0.088 | 3 | 0.718 |
JAK1 |
0.465 | -0.056 | 1 | 0.520 |
ALK |
0.464 | -0.081 | 3 | 0.658 |
FLT4 |
0.463 | -0.117 | 3 | 0.710 |
INSR |
0.463 | -0.090 | 3 | 0.676 |
DDR2 |
0.462 | -0.063 | 3 | 0.673 |
IGF1R |
0.461 | -0.057 | 3 | 0.617 |
PDGFRA |
0.461 | -0.139 | 3 | 0.726 |
TNNI3K_TYR |
0.458 | -0.132 | 1 | 0.553 |
MUSK |
0.453 | -0.089 | 1 | 0.530 |