Motif 1213 (n=68)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYH1 | C15orf38-AP3S2 | Y5 | ochoa | Arpin | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000256|ARBA:ARBA00025605}. |
| A2A3N6 | PIPSL | Y7 | ochoa | Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4) | Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins. |
| D3W0D1 | KLRF2 | Y7 | psp | Killer cell lectin-like receptor subfamily F member 2 (Lectin-like receptor F2) (Activating coreceptor NKp65) | C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A (PubMed:20194751, PubMed:25510854). Triggers degranulation in a SYK-dependent manner and stimulates SYK phosphotyrosinylation without recruiting SYK directly (PubMed:28082678). {ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:28082678}. |
| O95707 | POP4 | Y6 | ochoa | Ribonuclease P protein subunit p29 (hPOP4) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:10024167, ECO:0000269|PubMed:10352175, ECO:0000269|PubMed:30454648}. |
| P09234 | SNRPC | Y5 | ochoa | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}. |
| P15144 | ANPEP | Y6 | psp | Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}. |
| P20648 | ATP4A | Y7 | psp | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P47712 | PLA2G4A | Y7 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P50395 | GDI2 | Y5 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P51153 | RAB13 | Y5 | ochoa | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P61006 | RAB8A | Y5 | ochoa | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}. |
| P61019 | RAB2A | Y3 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P61026 | RAB10 | Y6 | ochoa | Ras-related protein Rab-10 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. |
| P62273 | RPS29 | Y7 | ochoa | Small ribosomal subunit protein uS14 (40S ribosomal protein S29) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| P62491 | RAB11A | Y8 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P62820 | RAB1A | Y8 | ochoa | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}. |
| P62993 | GRB2 | Y7 | psp | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis (PubMed:35831301, PubMed:37626338, PubMed:38182563). Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 (PubMed:9489702). In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation (PubMed:12171928, PubMed:25870599). Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232, PubMed:29523808). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 (PubMed:35831301, PubMed:38182563). Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 (PubMed:37328606). Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks (PubMed:38459011). Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process (PubMed:34348893). {ECO:0000269|PubMed:11726515, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:25413232, ECO:0000269|PubMed:25870599, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:34348893, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:36864087, ECO:0000269|PubMed:37328606, ECO:0000269|PubMed:37626338, ECO:0000269|PubMed:38182563, ECO:0000269|PubMed:38459011, ECO:0000269|PubMed:9489702}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment (PubMed:36171279). {ECO:0000269|PubMed:36171279, ECO:0000269|PubMed:8178156}. |
| P63010 | AP2B1 | Y6 | ochoa|psp | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P63316 | TNNC1 | Y5 | ochoa | Troponin C, slow skeletal and cardiac muscles (TN-C) | Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. |
| P68104 | EEF1A1 | T6 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| Q03135 | CAV1 | Y6 | ochoa|psp | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q05639 | EEF1A2 | T6 | ochoa | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q10567 | AP1B1 | Y6 | ochoa | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}. |
| Q12965 | MYO1E | Y7 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13561 | DCTN2 | Y6 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q14315 | FLNC | Y7 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q15056 | EIF4H | Y7 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15286 | RAB35 | Y5 | ochoa | Ras-related protein Rab-35 (EC 3.6.5.2) (GTP-binding protein RAY) (Ras-related protein Rab-1C) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:30905672). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:21951725). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (PubMed:16950109). May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:30905672}. |
| Q15691 | MAPRE1 | Y6 | ochoa | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q15717 | ELAVL1 | Y5 | ochoa | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15907 | RAB11B | Y8 | ochoa | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173}. |
| Q2HXU8 | CLEC12B | Y7 | psp | C-type lectin domain family 12 member B (Macrophage antigen H) | Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706). May protect target cells against natural killer cell-mediated lysis (PubMed:17562706). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951). {ECO:0000269|PubMed:17562706, ECO:0000269|PubMed:34310951}. |
| Q5BKZ1 | ZNF326 | Y7 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5EBL8 | PDZD11 | Y7 | ochoa | PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein) | Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33. {ECO:0000269|PubMed:30463011}. |
| Q5QGZ9 | CLEC12A | Y7 | ochoa | C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371) | Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation (By similarity). Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals (PubMed:38367667, PubMed:38386511, PubMed:39143217). Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980). Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation (PubMed:14739280, PubMed:16239426, PubMed:34234773). Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation (PubMed:39143217). This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions (By similarity). Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). Binding to monosodium urate crystals also promotes the type I interferon response (By similarity). Acts as an inhibitor of natural killer (NK) cell cytotoxicity (PubMed:15238421). Also acts as an ihibitor of dendritic cell maturation in an IL10-dependent manner (PubMed:16239426). {ECO:0000250|UniProtKB:Q504P2, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15238421, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:31269448, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:36542980, ECO:0000269|PubMed:38367667, ECO:0000269|PubMed:38386511, ECO:0000269|PubMed:39143217}. |
| Q5VTE0 | EEF1A1P5 | T6 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5XXA6 | ANO1 | Y7 | ochoa | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) | Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825, ECO:0000269|PubMed:37253099}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}. |
| Q7Z6K5 | ARPIN | Y5 | ochoa | Arpin (Arp2/3 inhibition protein) | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}. |
| Q86VP6 | CAND1 | Y6 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q8IV08 | PLD3 | Y7 | ochoa | 5'-3' exonuclease PLD3 (EC 3.1.16.1) ((S,S)-bis(monoacylglycero)phosphate synthase PLD3) (EC 3.1.4.-) (HindIII K4L homolog) (Hu-K4) (Phospholipase D3) | 5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules to form nucleoside 3'-monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894, PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, PubMed:38537643, PubMed:38697119). Partially redundant with PLD4, can cleave all four nucleotides displaying higher efficiency for ssDNA and RNA fragments initiated with uridine and guanosine residues and lower efficiency for cytidine-initiated substrates (PubMed:30111894, PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, PubMed:38537643, PubMed:38697119). As a result, it does not always degrade polynucleotides to the single nucleotide level, it can stall at specific sites sparing certain fragments from exonucleolytic degradation (PubMed:30111894, PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, PubMed:38537643, PubMed:38697119). Processes self and pathogenic ssDNA and RNA molecules that reach the endolysosomal compartment via phagocytosis or autophagy and may serve as 'danger' signals for recognition by innate immune receptors such as toll-like receptors (TLRs) (PubMed:34620855, PubMed:37225734, PubMed:38697119). Degrades mitochondrial CpG-rich ssDNA fragments to prevent TLR9 activation and autoinflammatory response, but it can cleave viral RNA to generate ligands for TLR7 activation and initiate antiviral immune responses (PubMed:34620855, PubMed:37225734, PubMed:38697119). In plasmacytoid dendritic cells, it cooperates with endonuclease RNASET2 to release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7 (PubMed:34620855, PubMed:37225734, PubMed:38697119). Produces 2',3'-cGMPs and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state (PubMed:34620855, PubMed:37225734, PubMed:38697119). Can exert polynucleotide phosphatase activity toward 5'-phosphorylated ssDNA substrates although at a slow rate (PubMed:38537643). Transphosphatidylase that catalyzes the exchange with R to S stereo-inversion of the glycerol moiety between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG) substrates to yield (S,S)-bis(monoacylglycero)phosphate (BMP) (PubMed:39423811). Can synthesize a variety of (S,S)-BMPs representing the main phospholipid constituent of lysosomal intralumenal vesicle (ILV) membranes that bind acid hydrolases for lipid degradation (PubMed:39423811). Regulates the homeostasis and interorganellar communication of the endolysosomal system with an overall impact on cellular removal of dysfunctional organelles via autophagy as well as proper protein and lipid turnover (PubMed:28128235, PubMed:29368044, PubMed:37225734). May play a role in myotube formation in response to ER stress (PubMed:22428023). {ECO:0000269|PubMed:22428023, ECO:0000269|PubMed:28128235, ECO:0000269|PubMed:29368044, ECO:0000269|PubMed:30111894, ECO:0000269|PubMed:30312375, ECO:0000269|PubMed:34620855, ECO:0000269|PubMed:37225734, ECO:0000269|PubMed:37994783, ECO:0000269|PubMed:38537643, ECO:0000269|PubMed:38697119, ECO:0000269|PubMed:39423811}. |
| Q8TAA9 | VANGL1 | Y7 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8WUD1 | RAB2B | Y3 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q92900 | UPF1 | Y6 | ochoa | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q92930 | RAB8B | Y5 | ochoa | Ras-related protein Rab-8B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}. |
| Q96DG6 | CMBL | Y6 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q9C0H5 | ARHGAP39 | Y7 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H098 | FAM107B | Y6 | ochoa | Protein FAM107B | None |
| Q9H0U4 | RAB1B | Y5 | ochoa | Ras-related protein Rab-1B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}. |
| Q9HBI0 | PARVG | Y7 | ochoa | Gamma-parvin | Plays a role with ILK in promoting the cell adhesion and spreading of leukocytes. {ECO:0000269|PubMed:16517730}. |
| Q9NUE0 | ZDHHC18 | Y6 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NY33 | DPP3 | Y6 | ochoa | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Q9NZC7 | WWOX | Y6 | ochoa | WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1) | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {ECO:0000250, ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}. |
| Q9NZS2 | KLRF1 | Y7 | psp | Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C) | Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606). {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:21149606}. |
| Q9P126 | CLEC1B | Y7 | psp | C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2) | C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). {ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18955485}.; FUNCTION: (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). {ECO:0000269|PubMed:18955485, ECO:0000305|PubMed:16174766}.; FUNCTION: (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507). {ECO:0000305|PubMed:16940507}. |
| P25685 | DNAJB1 | Y5 | Sugiyama | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P25685 | DNAJB1 | Y6 | Sugiyama | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P25786 | PSMA1 | Y6 | Sugiyama | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q5F1R6 | DNAJC21 | Y5 | Sugiyama | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| P61024 | CKS1B | Y7 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| P61313 | RPL15 | Y6 | Sugiyama | Large ribosomal subunit protein eL15 (60S ribosomal protein L15) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| O75190 | DNAJB6 | Y5 | Sugiyama | DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:28233300}.; FUNCTION: [Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation. {ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}. |
| Q9UDY4 | DNAJB4 | Y5 | Sugiyama | DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| Q9UDY4 | DNAJB4 | Y6 | Sugiyama | DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| O75525 | KHDRBS3 | Y5 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein) | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. {ECO:0000250|UniProtKB:Q9JLP1, ECO:0000250|UniProtKB:Q9R226, ECO:0000269|PubMed:10564820, ECO:0000269|PubMed:15901763, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:26758068}.; FUNCTION: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. {ECO:0000269|PubMed:11741900}. |
| Q5VWX1 | KHDRBS2 | Y6 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1) | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. {ECO:0000250|UniProtKB:Q920F3, ECO:0000250|UniProtKB:Q9WU01}. |
| Q9BV57 | ADI1 | Y6 | Sugiyama | Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L) | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742). {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544, ECO:0000269|PubMed:15938715}. |
| P31689 | DNAJA1 | Y7 | Sugiyama | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
| P31689 | DNAJA1 | Y8 | Sugiyama | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8873719 | RAB geranylgeranylation | 2.498002e-14 | 13.602 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.676840e-10 | 9.246 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.442547e-08 | 7.841 |
| R-HSA-199991 | Membrane Trafficking | 5.294572e-08 | 7.276 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.337008e-07 | 6.030 |
| R-HSA-8854214 | TBC/RABGAPs | 4.279489e-06 | 5.369 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 7.210801e-05 | 4.142 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.142278e-04 | 3.942 |
| R-HSA-3371556 | Cellular response to heat stress | 4.126637e-04 | 3.384 |
| R-HSA-392499 | Metabolism of proteins | 3.991324e-04 | 3.399 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 4.998683e-04 | 3.301 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.564073e-04 | 3.255 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.166949e-03 | 2.933 |
| R-HSA-3371568 | Attenuation phase | 1.380659e-03 | 2.860 |
| R-HSA-3371511 | HSF1 activation | 1.071267e-03 | 2.970 |
| R-HSA-597592 | Post-translational protein modification | 1.371441e-03 | 2.863 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.887585e-03 | 2.724 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.625890e-03 | 2.581 |
| R-HSA-2262752 | Cellular responses to stress | 2.675884e-03 | 2.573 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.702306e-03 | 2.244 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.925920e-03 | 2.308 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 4.722577e-03 | 2.326 |
| R-HSA-72766 | Translation | 4.671941e-03 | 2.331 |
| R-HSA-1483148 | Synthesis of PG | 4.315764e-03 | 2.365 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.309336e-03 | 2.275 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.527545e-03 | 2.257 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 6.044497e-03 | 2.219 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.703963e-03 | 2.174 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.179951e-03 | 2.144 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 7.008754e-03 | 2.154 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 8.037928e-03 | 2.095 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.939880e-03 | 2.049 |
| R-HSA-156902 | Peptide chain elongation | 1.030921e-02 | 1.987 |
| R-HSA-68886 | M Phase | 1.068064e-02 | 1.971 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.148770e-02 | 1.940 |
| R-HSA-390522 | Striated Muscle Contraction | 1.480440e-02 | 1.830 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.811660e-02 | 1.742 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.339573e-02 | 1.873 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.550820e-02 | 1.809 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.811660e-02 | 1.742 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.909557e-02 | 1.719 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.695812e-02 | 1.771 |
| R-HSA-5617833 | Cilium Assembly | 1.590916e-02 | 1.798 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.853906e-02 | 1.732 |
| R-HSA-69275 | G2/M Transition | 1.492736e-02 | 1.826 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.541331e-02 | 1.812 |
| R-HSA-1640170 | Cell Cycle | 1.866960e-02 | 1.729 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.937768e-02 | 1.713 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.733758e-02 | 1.761 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.973251e-02 | 1.705 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.973251e-02 | 1.705 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.002330e-02 | 1.698 |
| R-HSA-8865999 | MET activates PTPN11 | 2.271861e-02 | 1.644 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.230141e-02 | 1.652 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.230141e-02 | 1.652 |
| R-HSA-6798695 | Neutrophil degranulation | 2.277245e-02 | 1.643 |
| R-HSA-68875 | Mitotic Prophase | 2.411084e-02 | 1.618 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.415354e-02 | 1.617 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 3.610458e-02 | 1.442 |
| R-HSA-9645135 | STAT5 Activation | 4.052624e-02 | 1.392 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 4.492790e-02 | 1.347 |
| R-HSA-112412 | SOS-mediated signalling | 4.492790e-02 | 1.347 |
| R-HSA-111995 | phospho-PLA2 pathway | 4.930964e-02 | 1.307 |
| R-HSA-8875656 | MET receptor recycling | 4.930964e-02 | 1.307 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 4.930964e-02 | 1.307 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 5.367154e-02 | 1.270 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 5.801370e-02 | 1.236 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 7.092260e-02 | 1.149 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 7.943141e-02 | 1.100 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 8.786335e-02 | 1.056 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 9.205070e-02 | 1.036 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 9.205070e-02 | 1.036 |
| R-HSA-180292 | GAB1 signalosome | 1.003686e-01 | 0.998 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 1.044993e-01 | 0.981 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 1.086113e-01 | 0.964 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 1.208359e-01 | 0.918 |
| R-HSA-72649 | Translation initiation complex formation | 3.334716e-02 | 1.477 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 1.328950e-01 | 0.876 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.532653e-02 | 1.452 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.259920e-02 | 1.371 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.259920e-02 | 1.371 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.587323e-02 | 1.338 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.385687e-02 | 1.269 |
| R-HSA-380287 | Centrosome maturation | 5.622247e-02 | 1.250 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.374406e-02 | 1.132 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.770164e-02 | 1.110 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.444274e-02 | 1.073 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.581190e-02 | 1.066 |
| R-HSA-192823 | Viral mRNA Translation | 9.700160e-02 | 1.013 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.041955e-01 | 0.982 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.487757e-02 | 1.457 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.581190e-02 | 1.066 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 7.518666e-02 | 1.124 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.248739e-01 | 0.904 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.718784e-02 | 1.060 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 4.492790e-02 | 1.347 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 4.930964e-02 | 1.307 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.693065e-01 | 0.771 |
| R-HSA-2424491 | DAP12 signaling | 1.526320e-01 | 0.816 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 8.365695e-02 | 1.077 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 4.492790e-02 | 1.347 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.581190e-02 | 1.066 |
| R-HSA-74749 | Signal attenuation | 5.801370e-02 | 1.236 |
| R-HSA-209968 | Thyroxine biosynthesis | 1.487204e-01 | 0.828 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 5.367154e-02 | 1.270 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 5.801370e-02 | 1.236 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 5.801370e-02 | 1.236 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 6.233620e-02 | 1.205 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 6.663914e-02 | 1.176 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 7.092260e-02 | 1.149 |
| R-HSA-9027284 | Erythropoietin activates RAS | 8.365695e-02 | 1.077 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 8.365695e-02 | 1.077 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 9.205070e-02 | 1.036 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.127047e-01 | 0.948 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.167795e-01 | 0.933 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.288935e-01 | 0.890 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.288935e-01 | 0.890 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.735049e-02 | 1.428 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.408437e-01 | 0.851 |
| R-HSA-182971 | EGFR downregulation | 1.565259e-01 | 0.805 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.565259e-01 | 0.805 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.487204e-01 | 0.828 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.526320e-01 | 0.816 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.757321e-01 | 0.755 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.003686e-01 | 0.998 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 1.757321e-01 | 0.755 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 9.621908e-02 | 1.017 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.044993e-01 | 0.981 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.433121e-02 | 1.464 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.719257e-01 | 0.765 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.086113e-01 | 0.964 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.487204e-01 | 0.828 |
| R-HSA-8851805 | MET activates RAS signaling | 7.092260e-02 | 1.149 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 7.092260e-02 | 1.149 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 8.786335e-02 | 1.056 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 9.621908e-02 | 1.017 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 9.621908e-02 | 1.017 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.368784e-01 | 0.864 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.167795e-01 | 0.933 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.003686e-01 | 0.998 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 5.801370e-02 | 1.236 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 7.943141e-02 | 1.100 |
| R-HSA-1483115 | Hydrolysis of LPC | 7.943141e-02 | 1.100 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.003686e-01 | 0.998 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.368784e-01 | 0.864 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.526320e-01 | 0.816 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.604021e-01 | 0.795 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.757321e-01 | 0.755 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.757321e-01 | 0.755 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.526320e-01 | 0.816 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.288935e-01 | 0.890 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.268784e-02 | 1.278 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.551875e-02 | 1.593 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.127047e-01 | 0.948 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.127047e-01 | 0.948 |
| R-HSA-9842663 | Signaling by LTK | 7.092260e-02 | 1.149 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.152835e-02 | 1.382 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 7.092260e-02 | 1.149 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 8.365695e-02 | 1.077 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 8.365695e-02 | 1.077 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 9.205070e-02 | 1.036 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.447910e-01 | 0.839 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.487204e-01 | 0.828 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.719257e-01 | 0.765 |
| R-HSA-2408557 | Selenocysteine synthesis | 9.416600e-02 | 1.026 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.642608e-01 | 0.784 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.842856e-02 | 1.007 |
| R-HSA-9927353 | Co-inhibition by BTLA | 3.166281e-02 | 1.499 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 5.367154e-02 | 1.270 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 7.092260e-02 | 1.149 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 1.328950e-01 | 0.876 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.565259e-01 | 0.805 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 9.842856e-02 | 1.007 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.152813e-02 | 1.288 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 1.408437e-01 | 0.851 |
| R-HSA-8983432 | Interleukin-15 signaling | 7.092260e-02 | 1.149 |
| R-HSA-8951664 | Neddylation | 9.972463e-02 | 1.001 |
| R-HSA-8876725 | Protein methylation | 8.365695e-02 | 1.077 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.044993e-01 | 0.981 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 1.167795e-01 | 0.933 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 1.208359e-01 | 0.918 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 1.328950e-01 | 0.876 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.447910e-01 | 0.839 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 1.681019e-01 | 0.774 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 1.757321e-01 | 0.755 |
| R-HSA-210993 | Tie2 Signaling | 1.003686e-01 | 0.998 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.003686e-01 | 0.998 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.268784e-02 | 1.278 |
| R-HSA-203615 | eNOS activation | 1.719257e-01 | 0.765 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.599773e-02 | 1.585 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 8.365695e-02 | 1.077 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 8.786335e-02 | 1.056 |
| R-HSA-167044 | Signalling to RAS | 1.127047e-01 | 0.948 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.037785e-02 | 1.298 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.642608e-01 | 0.784 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.681019e-01 | 0.774 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.719257e-01 | 0.765 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.719257e-01 | 0.765 |
| R-HSA-169911 | Regulation of Apoptosis | 1.757321e-01 | 0.755 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.668045e-01 | 0.778 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.166899e-02 | 1.145 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 8.365695e-02 | 1.077 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.208359e-01 | 0.918 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.368037e-02 | 1.360 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.930964e-02 | 1.307 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 1.086113e-01 | 0.964 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.167795e-01 | 0.933 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.565259e-01 | 0.805 |
| R-HSA-4086400 | PCP/CE pathway | 5.983814e-02 | 1.223 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.487204e-01 | 0.828 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.408437e-01 | 0.851 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.468890e-01 | 0.833 |
| R-HSA-8964038 | LDL clearance | 1.208359e-01 | 0.918 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.385458e-02 | 1.358 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 8.365695e-02 | 1.077 |
| R-HSA-1237112 | Methionine salvage pathway | 1.044993e-01 | 0.981 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.288935e-01 | 0.890 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.408437e-01 | 0.851 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.962802e-02 | 1.225 |
| R-HSA-1433559 | Regulation of KIT signaling | 7.943141e-02 | 1.100 |
| R-HSA-186763 | Downstream signal transduction | 1.565259e-01 | 0.805 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.003686e-01 | 0.998 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.642608e-01 | 0.784 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.167795e-01 | 0.933 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.276744e-02 | 1.082 |
| R-HSA-391160 | Signal regulatory protein family interactions | 7.943141e-02 | 1.100 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 8.365695e-02 | 1.077 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 1.127047e-01 | 0.948 |
| R-HSA-210991 | Basigin interactions | 1.127047e-01 | 0.948 |
| R-HSA-983712 | Ion channel transport | 7.116356e-02 | 1.148 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.408437e-01 | 0.851 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.487204e-01 | 0.828 |
| R-HSA-8953854 | Metabolism of RNA | 9.815182e-02 | 1.008 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 7.943141e-02 | 1.100 |
| R-HSA-354192 | Integrin signaling | 1.642608e-01 | 0.784 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 1.642608e-01 | 0.784 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 1.189985e-01 | 0.924 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.563846e-01 | 0.806 |
| R-HSA-422475 | Axon guidance | 4.596354e-02 | 1.338 |
| R-HSA-196780 | Biotin transport and metabolism | 8.365695e-02 | 1.077 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.208359e-01 | 0.918 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.857414e-02 | 1.164 |
| R-HSA-9675108 | Nervous system development | 5.898851e-02 | 1.229 |
| R-HSA-162906 | HIV Infection | 1.053513e-01 | 0.977 |
| R-HSA-69206 | G1/S Transition | 1.358439e-01 | 0.867 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 1.681019e-01 | 0.774 |
| R-HSA-187687 | Signalling to ERKs | 1.757321e-01 | 0.755 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.741993e-01 | 0.759 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.533729e-01 | 0.814 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.503512e-02 | 1.259 |
| R-HSA-168249 | Innate Immune System | 4.395813e-02 | 1.357 |
| R-HSA-392518 | Signal amplification | 1.719257e-01 | 0.765 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.405280e-01 | 0.852 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 1.167795e-01 | 0.933 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.259920e-02 | 1.371 |
| R-HSA-8848021 | Signaling by PTK6 | 4.259920e-02 | 1.371 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 1.705815e-01 | 0.768 |
| R-HSA-9824446 | Viral Infection Pathways | 7.989127e-02 | 1.098 |
| R-HSA-9614085 | FOXO-mediated transcription | 9.135539e-02 | 1.039 |
| R-HSA-9679506 | SARS-CoV Infections | 4.928598e-02 | 1.307 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.036716e-02 | 1.219 |
| R-HSA-382551 | Transport of small molecules | 1.765201e-01 | 0.753 |
| R-HSA-1483257 | Phospholipid metabolism | 1.767469e-01 | 0.753 |
| R-HSA-69242 | S Phase | 1.774742e-01 | 0.751 |
| R-HSA-166520 | Signaling by NTRKs | 1.774742e-01 | 0.751 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.795212e-01 | 0.746 |
| R-HSA-8853659 | RET signaling | 1.795212e-01 | 0.746 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.795212e-01 | 0.746 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.795212e-01 | 0.746 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.795212e-01 | 0.746 |
| R-HSA-163560 | Triglyceride catabolism | 1.795212e-01 | 0.746 |
| R-HSA-195721 | Signaling by WNT | 1.801660e-01 | 0.744 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.807590e-01 | 0.743 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.824050e-01 | 0.739 |
| R-HSA-4641258 | Degradation of DVL | 1.832932e-01 | 0.737 |
| R-HSA-4641257 | Degradation of AXIN | 1.832932e-01 | 0.737 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.832932e-01 | 0.737 |
| R-HSA-8875878 | MET promotes cell motility | 1.870480e-01 | 0.728 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.870480e-01 | 0.728 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.890113e-01 | 0.724 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.907858e-01 | 0.719 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.907858e-01 | 0.719 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.907858e-01 | 0.719 |
| R-HSA-69541 | Stabilization of p53 | 1.907858e-01 | 0.719 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.939881e-01 | 0.712 |
| R-HSA-9711097 | Cellular response to starvation | 1.939881e-01 | 0.712 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.945067e-01 | 0.711 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.945067e-01 | 0.711 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.945067e-01 | 0.711 |
| R-HSA-9607240 | FLT3 Signaling | 1.982107e-01 | 0.703 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.982107e-01 | 0.703 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.982107e-01 | 0.703 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.982107e-01 | 0.703 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.982107e-01 | 0.703 |
| R-HSA-1500931 | Cell-Cell communication | 2.010497e-01 | 0.697 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.018979e-01 | 0.695 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.018979e-01 | 0.695 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.018979e-01 | 0.695 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.018979e-01 | 0.695 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.018979e-01 | 0.695 |
| R-HSA-168256 | Immune System | 2.033398e-01 | 0.692 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.039926e-01 | 0.690 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.039926e-01 | 0.690 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.055683e-01 | 0.687 |
| R-HSA-111996 | Ca-dependent events | 2.055683e-01 | 0.687 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.092221e-01 | 0.679 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.092221e-01 | 0.679 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.092221e-01 | 0.679 |
| R-HSA-9907900 | Proteasome assembly | 2.128594e-01 | 0.672 |
| R-HSA-2172127 | DAP12 interactions | 2.128594e-01 | 0.672 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.128594e-01 | 0.672 |
| R-HSA-69236 | G1 Phase | 2.128594e-01 | 0.672 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.128594e-01 | 0.672 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.157377e-01 | 0.666 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.164801e-01 | 0.665 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.164801e-01 | 0.665 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.164801e-01 | 0.665 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.164801e-01 | 0.665 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.164801e-01 | 0.665 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.164801e-01 | 0.665 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.164801e-01 | 0.665 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 2.164801e-01 | 0.665 |
| R-HSA-9824272 | Somitogenesis | 2.164801e-01 | 0.665 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.200844e-01 | 0.657 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.200844e-01 | 0.657 |
| R-HSA-437239 | Recycling pathway of L1 | 2.236723e-01 | 0.650 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.236723e-01 | 0.650 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.236723e-01 | 0.650 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.272439e-01 | 0.644 |
| R-HSA-9766229 | Degradation of CDH1 | 2.307994e-01 | 0.637 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.307994e-01 | 0.637 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.307994e-01 | 0.637 |
| R-HSA-168255 | Influenza Infection | 2.309294e-01 | 0.637 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.343387e-01 | 0.630 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 2.343387e-01 | 0.630 |
| R-HSA-109704 | PI3K Cascade | 2.343387e-01 | 0.630 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.377063e-01 | 0.624 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.378619e-01 | 0.624 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.378619e-01 | 0.624 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.378619e-01 | 0.624 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.382512e-01 | 0.623 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.406947e-01 | 0.619 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.413691e-01 | 0.617 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.413691e-01 | 0.617 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.413691e-01 | 0.617 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.448605e-01 | 0.611 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.448605e-01 | 0.611 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.448605e-01 | 0.611 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.448605e-01 | 0.611 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.461931e-01 | 0.609 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.483359e-01 | 0.605 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.483359e-01 | 0.605 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.517956e-01 | 0.599 |
| R-HSA-68877 | Mitotic Prometaphase | 2.546928e-01 | 0.594 |
| R-HSA-177929 | Signaling by EGFR | 2.552396e-01 | 0.593 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.552396e-01 | 0.593 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 2.552396e-01 | 0.593 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.552396e-01 | 0.593 |
| R-HSA-5578775 | Ion homeostasis | 2.552396e-01 | 0.593 |
| R-HSA-112399 | IRS-mediated signalling | 2.586679e-01 | 0.587 |
| R-HSA-1483166 | Synthesis of PA | 2.586679e-01 | 0.587 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.586679e-01 | 0.587 |
| R-HSA-8979227 | Triglyceride metabolism | 2.654779e-01 | 0.576 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.688598e-01 | 0.570 |
| R-HSA-351202 | Metabolism of polyamines | 2.688598e-01 | 0.570 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.717113e-01 | 0.566 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.722262e-01 | 0.565 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.722262e-01 | 0.565 |
| R-HSA-112043 | PLC beta mediated events | 2.722262e-01 | 0.565 |
| R-HSA-445717 | Aquaporin-mediated transport | 2.722262e-01 | 0.565 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.722262e-01 | 0.565 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.755774e-01 | 0.560 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.755774e-01 | 0.560 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.755774e-01 | 0.560 |
| R-HSA-186797 | Signaling by PDGF | 2.755774e-01 | 0.560 |
| R-HSA-9707616 | Heme signaling | 2.755774e-01 | 0.560 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.789134e-01 | 0.555 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.822342e-01 | 0.549 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.822342e-01 | 0.549 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.855399e-01 | 0.544 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.855399e-01 | 0.544 |
| R-HSA-397014 | Muscle contraction | 2.887251e-01 | 0.540 |
| R-HSA-112040 | G-protein mediated events | 2.921063e-01 | 0.534 |
| R-HSA-68882 | Mitotic Anaphase | 2.955216e-01 | 0.529 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.972196e-01 | 0.527 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.018445e-01 | 0.520 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.018445e-01 | 0.520 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.050611e-01 | 0.516 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.050611e-01 | 0.516 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.050611e-01 | 0.516 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.082631e-01 | 0.511 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.114505e-01 | 0.507 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.146235e-01 | 0.502 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.146235e-01 | 0.502 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 3.146235e-01 | 0.502 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.158548e-01 | 0.501 |
| R-HSA-917937 | Iron uptake and transport | 3.177820e-01 | 0.498 |
| R-HSA-5689603 | UCH proteinases | 3.209261e-01 | 0.494 |
| R-HSA-72312 | rRNA processing | 3.226074e-01 | 0.491 |
| R-HSA-5619084 | ABC transporter disorders | 3.271716e-01 | 0.485 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 3.302731e-01 | 0.481 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 3.310262e-01 | 0.480 |
| R-HSA-6806834 | Signaling by MET | 3.333604e-01 | 0.477 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.333604e-01 | 0.477 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.425385e-01 | 0.465 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.455700e-01 | 0.461 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.515918e-01 | 0.454 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.515918e-01 | 0.454 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.515918e-01 | 0.454 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 3.545822e-01 | 0.450 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.627420e-01 | 0.440 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.634720e-01 | 0.440 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.660509e-01 | 0.436 |
| R-HSA-202424 | Downstream TCR signaling | 3.664083e-01 | 0.436 |
| R-HSA-1280218 | Adaptive Immune System | 3.664175e-01 | 0.436 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.751373e-01 | 0.426 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.751373e-01 | 0.426 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.751373e-01 | 0.426 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.751373e-01 | 0.426 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.780205e-01 | 0.422 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.780205e-01 | 0.422 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.808906e-01 | 0.419 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.824978e-01 | 0.417 |
| R-HSA-5663205 | Infectious disease | 3.877251e-01 | 0.411 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.894228e-01 | 0.410 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.894228e-01 | 0.410 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.922410e-01 | 0.406 |
| R-HSA-190236 | Signaling by FGFR | 3.950463e-01 | 0.403 |
| R-HSA-446728 | Cell junction organization | 3.987681e-01 | 0.399 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.006188e-01 | 0.397 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.006188e-01 | 0.397 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.006188e-01 | 0.397 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.033860e-01 | 0.394 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.033860e-01 | 0.394 |
| R-HSA-111885 | Opioid Signalling | 4.116122e-01 | 0.386 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.164408e-01 | 0.380 |
| R-HSA-418346 | Platelet homeostasis | 4.197265e-01 | 0.377 |
| R-HSA-69239 | Synthesis of DNA | 4.224067e-01 | 0.374 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.224067e-01 | 0.374 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.224067e-01 | 0.374 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.250746e-01 | 0.372 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.250746e-01 | 0.372 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.259741e-01 | 0.371 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.275554e-01 | 0.369 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.277304e-01 | 0.369 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.277304e-01 | 0.369 |
| R-HSA-202403 | TCR signaling | 4.303741e-01 | 0.366 |
| R-HSA-6803157 | Antimicrobial peptides | 4.330057e-01 | 0.364 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.356254e-01 | 0.361 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.356254e-01 | 0.361 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.485455e-01 | 0.348 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.485455e-01 | 0.348 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.487184e-01 | 0.348 |
| R-HSA-373760 | L1CAM interactions | 4.510943e-01 | 0.346 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.536315e-01 | 0.343 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.561571e-01 | 0.341 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.586712e-01 | 0.338 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.636651e-01 | 0.334 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.636651e-01 | 0.334 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.686134e-01 | 0.329 |
| R-HSA-194138 | Signaling by VEGF | 4.759517e-01 | 0.322 |
| R-HSA-69481 | G2/M Checkpoints | 4.807882e-01 | 0.318 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.879606e-01 | 0.312 |
| R-HSA-5576891 | Cardiac conduction | 4.926877e-01 | 0.307 |
| R-HSA-9909396 | Circadian clock | 4.950351e-01 | 0.305 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.977248e-01 | 0.303 |
| R-HSA-109582 | Hemostasis | 5.094479e-01 | 0.293 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.111697e-01 | 0.291 |
| R-HSA-6807070 | PTEN Regulation | 5.134327e-01 | 0.290 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.156854e-01 | 0.288 |
| R-HSA-9664407 | Parasite infection | 5.156854e-01 | 0.288 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.156854e-01 | 0.288 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.179278e-01 | 0.286 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.267955e-01 | 0.278 |
| R-HSA-9758941 | Gastrulation | 5.376540e-01 | 0.269 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.440508e-01 | 0.264 |
| R-HSA-2142753 | Arachidonate metabolism | 5.440508e-01 | 0.264 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.440508e-01 | 0.264 |
| R-HSA-69306 | DNA Replication | 5.461636e-01 | 0.263 |
| R-HSA-9612973 | Autophagy | 5.524442e-01 | 0.258 |
| R-HSA-109581 | Apoptosis | 5.647492e-01 | 0.248 |
| R-HSA-449147 | Signaling by Interleukins | 5.742414e-01 | 0.241 |
| R-HSA-72306 | tRNA processing | 5.825836e-01 | 0.235 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.845201e-01 | 0.233 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.864478e-01 | 0.232 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.883667e-01 | 0.230 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.883667e-01 | 0.230 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.883667e-01 | 0.230 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.266934e-01 | 0.203 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.301544e-01 | 0.201 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.369819e-01 | 0.196 |
| R-HSA-72172 | mRNA Splicing | 6.453415e-01 | 0.190 |
| R-HSA-5357801 | Programmed Cell Death | 6.469905e-01 | 0.189 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.583237e-01 | 0.182 |
| R-HSA-162582 | Signal Transduction | 6.638241e-01 | 0.178 |
| R-HSA-418990 | Adherens junctions interactions | 6.677515e-01 | 0.175 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.799239e-01 | 0.168 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 6.843742e-01 | 0.165 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.858440e-01 | 0.164 |
| R-HSA-8939211 | ESR-mediated signaling | 6.959454e-01 | 0.157 |
| R-HSA-157118 | Signaling by NOTCH | 7.001759e-01 | 0.155 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.098224e-01 | 0.149 |
| R-HSA-421270 | Cell-cell junction organization | 7.151966e-01 | 0.146 |
| R-HSA-5688426 | Deubiquitination | 7.204726e-01 | 0.142 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.307369e-01 | 0.136 |
| R-HSA-416476 | G alpha (q) signalling events | 7.319935e-01 | 0.135 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.489904e-01 | 0.126 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.501629e-01 | 0.125 |
| R-HSA-9658195 | Leishmania infection | 7.524918e-01 | 0.123 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.524918e-01 | 0.123 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.536482e-01 | 0.123 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.967376e-01 | 0.099 |
| R-HSA-1266738 | Developmental Biology | 8.148050e-01 | 0.089 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.315832e-01 | 0.080 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.323742e-01 | 0.080 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.474457e-01 | 0.072 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.523983e-01 | 0.069 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.571922e-01 | 0.067 |
| R-HSA-418594 | G alpha (i) signalling events | 8.637753e-01 | 0.064 |
| R-HSA-8978868 | Fatty acid metabolism | 8.637753e-01 | 0.064 |
| R-HSA-1643685 | Disease | 8.665519e-01 | 0.062 |
| R-HSA-388396 | GPCR downstream signalling | 8.857160e-01 | 0.053 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.866615e-01 | 0.052 |
| R-HSA-112316 | Neuronal System | 8.979187e-01 | 0.047 |
| R-HSA-372790 | Signaling by GPCR | 9.168737e-01 | 0.038 |
| R-HSA-211859 | Biological oxidations | 9.213784e-01 | 0.036 |
| R-HSA-556833 | Metabolism of lipids | 9.248414e-01 | 0.034 |
| R-HSA-212436 | Generic Transcription Pathway | 9.388837e-01 | 0.027 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.620228e-01 | 0.017 |
| R-HSA-74160 | Gene expression (Transcription) | 9.857702e-01 | 0.006 |
| R-HSA-1430728 | Metabolism | 9.880457e-01 | 0.005 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
EPHA6 |
0.790 | 0.131 | -1 | 0.843 |
PDHK3_TYR |
0.789 | 0.029 | 4 | 0.809 |
BLK |
0.787 | 0.185 | -1 | 0.810 |
EPHB4 |
0.786 | 0.108 | -1 | 0.827 |
TXK |
0.786 | 0.129 | 1 | 0.794 |
ABL2 |
0.786 | 0.109 | -1 | 0.824 |
CSF1R |
0.783 | 0.097 | 3 | 0.653 |
MAP2K4_TYR |
0.782 | -0.044 | -1 | 0.850 |
ABL1 |
0.782 | 0.094 | -1 | 0.816 |
YES1 |
0.782 | 0.068 | -1 | 0.825 |
INSRR |
0.781 | 0.083 | 3 | 0.618 |
PDHK1_TYR |
0.781 | -0.035 | -1 | 0.865 |
SRMS |
0.781 | 0.096 | 1 | 0.818 |
EPHB2 |
0.780 | 0.090 | -1 | 0.806 |
TNK2 |
0.780 | 0.116 | 3 | 0.668 |
MST1R |
0.780 | 0.050 | 3 | 0.670 |
MAP2K6_TYR |
0.780 | -0.060 | -1 | 0.850 |
FER |
0.780 | 0.054 | 1 | 0.832 |
FGFR2 |
0.779 | 0.080 | 3 | 0.657 |
FGFR1 |
0.779 | 0.075 | 3 | 0.629 |
RET |
0.779 | -0.024 | 1 | 0.761 |
MAP2K7_TYR |
0.779 | -0.154 | 2 | 0.829 |
LCK |
0.778 | 0.091 | -1 | 0.800 |
EPHA4 |
0.778 | 0.065 | 2 | 0.782 |
TYRO3 |
0.778 | 0.007 | 3 | 0.621 |
PDHK4_TYR |
0.778 | -0.066 | 2 | 0.834 |
MET |
0.778 | 0.073 | 3 | 0.656 |
JAK3 |
0.777 | 0.042 | 1 | 0.746 |
HCK |
0.777 | 0.072 | -1 | 0.796 |
ROS1 |
0.777 | 0.015 | 3 | 0.618 |
TESK1_TYR |
0.776 | -0.130 | 3 | 0.664 |
EPHB1 |
0.776 | 0.043 | 1 | 0.816 |
EPHB3 |
0.776 | 0.055 | -1 | 0.804 |
PKMYT1_TYR |
0.776 | -0.101 | 3 | 0.654 |
BMPR2_TYR |
0.776 | -0.062 | -1 | 0.843 |
MERTK |
0.776 | 0.093 | 3 | 0.645 |
AXL |
0.776 | 0.094 | 3 | 0.661 |
KIT |
0.775 | 0.047 | 3 | 0.650 |
JAK2 |
0.775 | -0.002 | 1 | 0.761 |
DDR1 |
0.775 | 0.002 | 4 | 0.786 |
FRK |
0.774 | 0.096 | -1 | 0.805 |
TYK2 |
0.772 | -0.063 | 1 | 0.764 |
FGFR3 |
0.772 | 0.075 | 3 | 0.648 |
PINK1_TYR |
0.772 | -0.173 | 1 | 0.767 |
EPHA7 |
0.772 | 0.075 | 2 | 0.788 |
KDR |
0.771 | 0.060 | 3 | 0.636 |
EPHA8 |
0.771 | 0.093 | -1 | 0.805 |
LIMK2_TYR |
0.771 | -0.093 | -3 | 0.702 |
ITK |
0.771 | -0.017 | -1 | 0.777 |
FGFR4 |
0.771 | 0.083 | -1 | 0.808 |
EPHA1 |
0.770 | 0.090 | 3 | 0.652 |
FYN |
0.770 | 0.062 | -1 | 0.776 |
TEC |
0.770 | 0.054 | -1 | 0.739 |
PTK2B |
0.770 | 0.075 | -1 | 0.764 |
TEK |
0.770 | -0.009 | 3 | 0.597 |
EPHA5 |
0.770 | 0.096 | 2 | 0.782 |
FGR |
0.770 | -0.035 | 1 | 0.780 |
BMX |
0.769 | 0.031 | -1 | 0.742 |
EGFR |
0.769 | 0.071 | 1 | 0.693 |
INSR |
0.768 | 0.024 | 3 | 0.607 |
LTK |
0.768 | 0.011 | 3 | 0.596 |
FLT3 |
0.767 | -0.022 | 3 | 0.612 |
NTRK1 |
0.767 | 0.019 | -1 | 0.802 |
PDGFRB |
0.767 | -0.033 | 3 | 0.646 |
LIMK1_TYR |
0.767 | -0.152 | 2 | 0.800 |
LYN |
0.767 | 0.052 | 3 | 0.575 |
ERBB2 |
0.767 | 0.014 | 1 | 0.743 |
ALK |
0.766 | -0.002 | 3 | 0.580 |
EPHA2 |
0.766 | 0.091 | -1 | 0.778 |
NTRK3 |
0.766 | 0.048 | -1 | 0.768 |
EPHA3 |
0.765 | 0.015 | 2 | 0.774 |
NTRK2 |
0.764 | 0.026 | 3 | 0.640 |
SRC |
0.764 | 0.031 | -1 | 0.793 |
FLT1 |
0.763 | 0.003 | -1 | 0.829 |
CSK |
0.762 | 0.013 | 2 | 0.792 |
JAK1 |
0.762 | 0.014 | 1 | 0.697 |
TNK1 |
0.762 | -0.038 | 3 | 0.603 |
FLT4 |
0.761 | 0.002 | 3 | 0.618 |
PDGFRA |
0.761 | -0.054 | 3 | 0.646 |
MATK |
0.760 | 0.004 | -1 | 0.790 |
NEK10_TYR |
0.759 | -0.074 | 1 | 0.664 |
BTK |
0.758 | -0.070 | -1 | 0.733 |
ERBB4 |
0.758 | 0.065 | 1 | 0.692 |
DDR2 |
0.758 | 0.017 | 3 | 0.629 |
PTK2 |
0.757 | 0.053 | -1 | 0.759 |
PTK6 |
0.756 | -0.094 | -1 | 0.747 |
IGF1R |
0.756 | 0.006 | 3 | 0.551 |
SYK |
0.753 | 0.021 | -1 | 0.770 |
TNNI3K_TYR |
0.752 | -0.099 | 1 | 0.731 |
MUSK |
0.747 | -0.019 | 1 | 0.694 |
FES |
0.745 | 0.010 | -1 | 0.732 |
WEE1_TYR |
0.737 | -0.146 | -1 | 0.752 |
ZAP70 |
0.734 | -0.003 | -1 | 0.724 |
TGFBR1 |
0.706 | 0.178 | -2 | 0.872 |
MOS |
0.704 | 0.140 | 1 | 0.827 |
ALK4 |
0.703 | 0.147 | -2 | 0.881 |
BMPR2 |
0.700 | 0.046 | -2 | 0.881 |
PRPK |
0.699 | -0.006 | -1 | 0.848 |
ACVR2B |
0.697 | 0.163 | -2 | 0.887 |
CAMK1B |
0.697 | 0.035 | -3 | 0.696 |
ALK2 |
0.697 | 0.149 | -2 | 0.871 |
TSSK2 |
0.697 | 0.112 | -5 | 0.518 |
ACVR2A |
0.696 | 0.154 | -2 | 0.890 |
TTK |
0.696 | 0.189 | -2 | 0.893 |
LATS1 |
0.695 | 0.073 | -3 | 0.692 |
BMPR1B |
0.695 | 0.134 | 1 | 0.698 |
DAPK2 |
0.694 | 0.023 | -3 | 0.681 |
AMPKA1 |
0.693 | 0.104 | -3 | 0.689 |
TSSK1 |
0.692 | 0.106 | -3 | 0.714 |
COT |
0.692 | 0.014 | 2 | 0.810 |
MEK1 |
0.692 | -0.026 | 2 | 0.840 |
NIK |
0.691 | -0.033 | -3 | 0.708 |
CAMLCK |
0.691 | 0.004 | -2 | 0.800 |
SKMLCK |
0.690 | 0.062 | -2 | 0.792 |
CDC7 |
0.690 | 0.066 | 1 | 0.809 |
TGFBR2 |
0.690 | 0.121 | -2 | 0.901 |
CHK1 |
0.689 | 0.134 | -3 | 0.690 |
BRAF |
0.689 | -0.017 | -4 | 0.705 |
VRK2 |
0.689 | -0.176 | 1 | 0.762 |
BMPR1A |
0.688 | 0.143 | 1 | 0.694 |
PLK3 |
0.687 | 0.091 | 2 | 0.815 |
TBK1 |
0.687 | -0.009 | 1 | 0.686 |
CAMK2G |
0.687 | 0.007 | 2 | 0.847 |
PLK1 |
0.687 | 0.059 | -2 | 0.871 |
TLK2 |
0.686 | 0.028 | 1 | 0.709 |
PKR |
0.686 | -0.064 | 1 | 0.727 |
ALPHAK3 |
0.686 | 0.048 | -1 | 0.823 |
AMPKA2 |
0.686 | 0.085 | -3 | 0.665 |
ANKRD3 |
0.686 | -0.010 | 1 | 0.757 |
DCAMKL1 |
0.685 | 0.071 | -3 | 0.659 |
RAF1 |
0.685 | -0.079 | 1 | 0.758 |
MEKK2 |
0.685 | -0.029 | 2 | 0.776 |
NDR2 |
0.685 | 0.035 | -3 | 0.684 |
GCN2 |
0.685 | 0.018 | 2 | 0.827 |
GAK |
0.684 | -0.067 | 1 | 0.701 |
ATR |
0.684 | -0.043 | 1 | 0.753 |
CLK3 |
0.684 | 0.034 | 1 | 0.713 |
TLK1 |
0.683 | 0.065 | -2 | 0.864 |
MARK4 |
0.683 | 0.030 | 4 | 0.833 |
DAPK3 |
0.682 | 0.048 | -3 | 0.649 |
RIPK3 |
0.682 | 0.072 | 3 | 0.654 |
CDKL1 |
0.682 | -0.025 | -3 | 0.620 |
GRK7 |
0.682 | 0.029 | 1 | 0.733 |
PERK |
0.682 | 0.027 | -2 | 0.882 |
ICK |
0.681 | -0.011 | -3 | 0.650 |
LATS2 |
0.681 | 0.043 | -5 | 0.454 |
DCAMKL2 |
0.681 | 0.077 | -3 | 0.680 |
DLK |
0.681 | -0.163 | 1 | 0.751 |
PLK4 |
0.681 | 0.067 | 2 | 0.747 |
PIM3 |
0.681 | -0.035 | -3 | 0.675 |
GRK6 |
0.680 | -0.040 | 1 | 0.775 |
PDHK4 |
0.680 | -0.141 | 1 | 0.770 |
ATM |
0.680 | 0.065 | 1 | 0.705 |
ULK2 |
0.679 | -0.091 | 2 | 0.787 |
IKKE |
0.679 | -0.050 | 1 | 0.688 |
EEF2K |
0.679 | -0.044 | 3 | 0.618 |
CHAK2 |
0.679 | -0.011 | -1 | 0.860 |
PRKD1 |
0.679 | 0.026 | -3 | 0.649 |
DSTYK |
0.679 | -0.036 | 2 | 0.770 |
HUNK |
0.678 | -0.058 | 2 | 0.819 |
NEK5 |
0.678 | -0.056 | 1 | 0.730 |
PKN3 |
0.678 | -0.025 | -3 | 0.646 |
PLK2 |
0.678 | 0.128 | -3 | 0.745 |
PDHK1 |
0.677 | -0.129 | 1 | 0.767 |
VRK1 |
0.677 | -0.159 | 2 | 0.791 |
MEKK1 |
0.677 | -0.086 | 1 | 0.734 |
CAMK2B |
0.677 | 0.055 | 2 | 0.827 |
CAMK2D |
0.677 | 0.019 | -3 | 0.646 |
MEK5 |
0.677 | -0.170 | 2 | 0.792 |
MEK2 |
0.676 | -0.071 | 2 | 0.817 |
MLK2 |
0.676 | -0.109 | 2 | 0.755 |
MASTL |
0.676 | -0.147 | -2 | 0.761 |
RSK2 |
0.676 | 0.008 | -3 | 0.623 |
NDR1 |
0.676 | -0.011 | -3 | 0.672 |
MEKK3 |
0.676 | -0.084 | 1 | 0.717 |
NUAK2 |
0.675 | -0.007 | -3 | 0.676 |
PASK |
0.675 | -0.029 | -3 | 0.659 |
TAO3 |
0.675 | -0.095 | 1 | 0.724 |
MAP3K15 |
0.675 | -0.086 | 1 | 0.700 |
ERK5 |
0.675 | -0.021 | 1 | 0.699 |
ASK1 |
0.675 | -0.082 | 1 | 0.695 |
P70S6KB |
0.675 | -0.023 | -3 | 0.639 |
PDK1 |
0.675 | -0.102 | 1 | 0.709 |
SSTK |
0.675 | 0.064 | 4 | 0.850 |
HRI |
0.675 | -0.011 | -2 | 0.888 |
NLK |
0.675 | -0.121 | 1 | 0.688 |
NEK6 |
0.675 | -0.019 | -2 | 0.875 |
MST2 |
0.674 | -0.089 | 1 | 0.732 |
IKKA |
0.674 | -0.047 | -2 | 0.678 |
BRSK1 |
0.674 | 0.062 | -3 | 0.640 |
SMMLCK |
0.674 | 0.001 | -3 | 0.637 |
YSK4 |
0.673 | -0.122 | 1 | 0.710 |
PAK1 |
0.673 | -0.007 | -2 | 0.716 |
P90RSK |
0.673 | -0.011 | -3 | 0.616 |
MLK1 |
0.673 | -0.119 | 2 | 0.719 |
GRK4 |
0.673 | -0.052 | -2 | 0.796 |
RSK3 |
0.673 | 0.000 | -3 | 0.621 |
WNK3 |
0.673 | -0.081 | 1 | 0.739 |
WNK1 |
0.672 | -0.040 | -2 | 0.793 |
ULK1 |
0.672 | -0.066 | -3 | 0.604 |
CAMK4 |
0.672 | 0.013 | -3 | 0.659 |
OSR1 |
0.672 | -0.087 | 2 | 0.756 |
NEK7 |
0.672 | -0.089 | -3 | 0.591 |
GRK5 |
0.672 | -0.151 | -3 | 0.679 |
PIM1 |
0.672 | -0.021 | -3 | 0.633 |
TAO2 |
0.672 | -0.130 | 2 | 0.750 |
CDKL5 |
0.671 | -0.005 | -3 | 0.610 |
TTBK2 |
0.671 | -0.070 | 2 | 0.727 |
MEKK6 |
0.671 | -0.087 | 1 | 0.728 |
MARK2 |
0.671 | 0.031 | 4 | 0.774 |
NUAK1 |
0.671 | 0.059 | -3 | 0.648 |
LKB1 |
0.671 | -0.138 | -3 | 0.600 |
LRRK2 |
0.671 | -0.160 | 2 | 0.773 |
STLK3 |
0.670 | -0.081 | 1 | 0.702 |
IKKB |
0.670 | -0.136 | -2 | 0.681 |
MST1 |
0.670 | -0.120 | 1 | 0.719 |
CAMKK2 |
0.670 | -0.139 | -2 | 0.702 |
MELK |
0.670 | 0.019 | -3 | 0.648 |
MAPKAPK3 |
0.670 | -0.014 | -3 | 0.615 |
TNIK |
0.670 | -0.110 | 3 | 0.648 |
CAMK2A |
0.670 | 0.044 | 2 | 0.830 |
PAK3 |
0.670 | -0.018 | -2 | 0.715 |
CAMK1D |
0.670 | 0.041 | -3 | 0.568 |
ZAK |
0.669 | -0.120 | 1 | 0.706 |
MINK |
0.669 | -0.135 | 1 | 0.695 |
PRKD2 |
0.669 | 0.028 | -3 | 0.634 |
NEK1 |
0.669 | -0.120 | 1 | 0.718 |
DMPK1 |
0.669 | 0.025 | -3 | 0.630 |
NEK9 |
0.669 | -0.135 | 2 | 0.764 |
MAPKAPK2 |
0.669 | 0.018 | -3 | 0.592 |
BRSK2 |
0.669 | 0.041 | -3 | 0.654 |
QSK |
0.669 | 0.030 | 4 | 0.825 |
PKACG |
0.669 | 0.009 | -2 | 0.711 |
NEK8 |
0.669 | -0.138 | 2 | 0.736 |
CAMKK1 |
0.669 | -0.177 | -2 | 0.700 |
RIPK1 |
0.669 | -0.099 | 1 | 0.698 |
GCK |
0.668 | -0.136 | 1 | 0.686 |
GRK1 |
0.668 | -0.047 | -2 | 0.726 |
ROCK2 |
0.668 | 0.006 | -3 | 0.632 |
DAPK1 |
0.668 | 0.004 | -3 | 0.621 |
PKCD |
0.668 | -0.047 | 2 | 0.712 |
PRKD3 |
0.667 | 0.007 | -3 | 0.604 |
PRP4 |
0.667 | -0.052 | -3 | 0.597 |
P38A |
0.667 | -0.030 | 1 | 0.557 |
IRE2 |
0.667 | -0.032 | 2 | 0.715 |
JNK3 |
0.667 | -0.049 | 1 | 0.517 |
TAK1 |
0.667 | -0.212 | 1 | 0.725 |
PAK2 |
0.667 | -0.043 | -2 | 0.702 |
MSK1 |
0.666 | 0.010 | -3 | 0.576 |
NEK11 |
0.666 | -0.119 | 1 | 0.696 |
HIPK4 |
0.666 | -0.037 | 1 | 0.616 |
MLK4 |
0.666 | -0.063 | 2 | 0.665 |
MTOR |
0.666 | -0.187 | 1 | 0.684 |
MNK2 |
0.666 | 0.047 | -2 | 0.746 |
SIK |
0.665 | 0.026 | -3 | 0.615 |
NIM1 |
0.665 | -0.045 | 3 | 0.620 |
P38B |
0.665 | -0.025 | 1 | 0.512 |
HGK |
0.665 | -0.134 | 3 | 0.635 |
RSK4 |
0.665 | 0.001 | -3 | 0.597 |
JNK2 |
0.665 | -0.038 | 1 | 0.469 |
MST4 |
0.664 | -0.066 | 2 | 0.696 |
MYLK4 |
0.664 | -0.004 | -2 | 0.714 |
WNK4 |
0.664 | -0.084 | -2 | 0.781 |
BIKE |
0.664 | -0.036 | 1 | 0.555 |
MARK1 |
0.664 | 0.011 | 4 | 0.806 |
CK2A2 |
0.664 | 0.122 | 1 | 0.731 |
MSK2 |
0.664 | -0.028 | -3 | 0.565 |
MARK3 |
0.663 | 0.015 | 4 | 0.785 |
AURB |
0.663 | 0.014 | -2 | 0.625 |
AURA |
0.663 | -0.001 | -2 | 0.593 |
KHS1 |
0.663 | -0.111 | 1 | 0.687 |
SGK3 |
0.663 | -0.012 | -3 | 0.595 |
SRPK1 |
0.662 | -0.020 | -3 | 0.594 |
NEK4 |
0.662 | -0.143 | 1 | 0.700 |
CHAK1 |
0.662 | -0.104 | 2 | 0.739 |
GRK2 |
0.662 | -0.057 | -2 | 0.677 |
MNK1 |
0.662 | 0.039 | -2 | 0.762 |
AURC |
0.661 | 0.024 | -2 | 0.634 |
QIK |
0.661 | -0.035 | -3 | 0.639 |
PBK |
0.661 | -0.080 | 1 | 0.646 |
DNAPK |
0.661 | -0.006 | 1 | 0.631 |
PKN2 |
0.661 | -0.088 | -3 | 0.658 |
IRAK4 |
0.661 | -0.071 | 1 | 0.694 |
PKACB |
0.660 | 0.020 | -2 | 0.652 |
FAM20C |
0.660 | 0.015 | 2 | 0.540 |
IRE1 |
0.660 | -0.092 | 1 | 0.666 |
SRPK3 |
0.660 | -0.028 | -3 | 0.559 |
DYRK1A |
0.660 | -0.015 | 1 | 0.597 |
AKT2 |
0.659 | -0.014 | -3 | 0.552 |
MLK3 |
0.659 | -0.111 | 2 | 0.651 |
MPSK1 |
0.658 | -0.098 | 1 | 0.613 |
MRCKA |
0.658 | -0.006 | -3 | 0.607 |
PKG2 |
0.658 | 0.012 | -2 | 0.658 |
MST3 |
0.658 | -0.161 | 2 | 0.691 |
CAMK1G |
0.658 | -0.002 | -3 | 0.597 |
NEK2 |
0.658 | -0.144 | 2 | 0.723 |
P38G |
0.658 | -0.036 | 1 | 0.399 |
CLK4 |
0.657 | -0.023 | -3 | 0.623 |
SMG1 |
0.657 | -0.055 | 1 | 0.703 |
LOK |
0.657 | -0.106 | -2 | 0.744 |
KHS2 |
0.656 | -0.110 | 1 | 0.681 |
CDK5 |
0.656 | -0.051 | 1 | 0.534 |
YSK1 |
0.656 | -0.152 | 2 | 0.696 |
PIM2 |
0.656 | -0.053 | -3 | 0.596 |
DYRK2 |
0.656 | -0.052 | 1 | 0.523 |
P38D |
0.655 | -0.019 | 1 | 0.415 |
HPK1 |
0.655 | -0.156 | 1 | 0.676 |
BCKDK |
0.655 | -0.138 | -1 | 0.723 |
DRAK1 |
0.654 | -0.125 | 1 | 0.653 |
CAMK1A |
0.654 | 0.024 | -3 | 0.540 |
MYO3A |
0.653 | -0.147 | 1 | 0.670 |
CRIK |
0.653 | -0.012 | -3 | 0.554 |
ERK2 |
0.653 | -0.064 | 1 | 0.531 |
CK2A1 |
0.653 | 0.097 | 1 | 0.715 |
KIS |
0.653 | -0.021 | 1 | 0.560 |
MRCKB |
0.653 | -0.015 | -3 | 0.595 |
ROCK1 |
0.653 | -0.016 | -3 | 0.606 |
JNK1 |
0.652 | -0.040 | 1 | 0.471 |
AAK1 |
0.652 | -0.008 | 1 | 0.447 |
SRPK2 |
0.652 | -0.022 | -3 | 0.527 |
PKACA |
0.652 | 0.021 | -2 | 0.611 |
IRAK1 |
0.651 | -0.131 | -1 | 0.716 |
CDK8 |
0.651 | -0.067 | 1 | 0.508 |
HIPK1 |
0.651 | -0.047 | 1 | 0.535 |
SGK1 |
0.651 | -0.011 | -3 | 0.477 |
CDK1 |
0.651 | -0.058 | 1 | 0.471 |
PAK6 |
0.651 | 0.012 | -2 | 0.637 |
CLK1 |
0.651 | -0.016 | -3 | 0.616 |
SNRK |
0.650 | -0.100 | 2 | 0.706 |
CDK7 |
0.650 | -0.054 | 1 | 0.520 |
CHK2 |
0.650 | -0.001 | -3 | 0.514 |
PRKX |
0.650 | 0.044 | -3 | 0.565 |
PKCZ |
0.650 | -0.087 | 2 | 0.698 |
ERK1 |
0.650 | -0.045 | 1 | 0.482 |
PKCB |
0.650 | -0.079 | 2 | 0.625 |
PHKG1 |
0.650 | -0.060 | -3 | 0.663 |
NEK3 |
0.650 | -0.090 | 1 | 0.700 |
GRK3 |
0.650 | -0.046 | -2 | 0.635 |
MYO3B |
0.649 | -0.165 | 2 | 0.709 |
AKT1 |
0.649 | -0.019 | -3 | 0.563 |
PKCH |
0.648 | -0.097 | 2 | 0.654 |
CLK2 |
0.648 | -0.007 | -3 | 0.629 |
P70S6K |
0.648 | -0.054 | -3 | 0.539 |
SLK |
0.648 | -0.100 | -2 | 0.693 |
GSK3B |
0.647 | -0.048 | 4 | 0.335 |
PKCG |
0.647 | -0.103 | 2 | 0.655 |
HIPK3 |
0.647 | -0.061 | 1 | 0.569 |
TAO1 |
0.647 | -0.128 | 1 | 0.668 |
SBK |
0.647 | -0.009 | -3 | 0.463 |
TTBK1 |
0.646 | -0.081 | 2 | 0.669 |
CDK17 |
0.646 | -0.025 | 1 | 0.402 |
BUB1 |
0.646 | -0.034 | -5 | 0.474 |
DYRK1B |
0.646 | -0.046 | 1 | 0.490 |
PINK1 |
0.646 | -0.210 | 1 | 0.657 |
CDK18 |
0.646 | -0.013 | 1 | 0.450 |
CDK2 |
0.645 | -0.092 | 1 | 0.572 |
MAK |
0.644 | -0.008 | -2 | 0.700 |
GSK3A |
0.644 | -0.041 | 4 | 0.337 |
PKCA |
0.644 | -0.113 | 2 | 0.627 |
MAPKAPK5 |
0.644 | -0.084 | -3 | 0.510 |
CK1E |
0.642 | -0.056 | -3 | 0.418 |
DYRK4 |
0.641 | -0.040 | 1 | 0.455 |
CDK3 |
0.641 | -0.044 | 1 | 0.421 |
DYRK3 |
0.641 | -0.048 | 1 | 0.536 |
RIPK2 |
0.641 | -0.141 | 1 | 0.682 |
CK1D |
0.641 | -0.056 | -3 | 0.366 |
HIPK2 |
0.640 | -0.043 | 1 | 0.430 |
PAK5 |
0.640 | -0.012 | -2 | 0.587 |
PHKG2 |
0.640 | -0.039 | -3 | 0.662 |
CDK13 |
0.639 | -0.092 | 1 | 0.496 |
PKCT |
0.639 | -0.092 | 2 | 0.659 |
CDK19 |
0.639 | -0.068 | 1 | 0.461 |
CDK14 |
0.639 | -0.035 | 1 | 0.483 |
PAK4 |
0.638 | -0.006 | -2 | 0.595 |
CK1A2 |
0.638 | -0.052 | -3 | 0.368 |
CK1G1 |
0.637 | -0.052 | -3 | 0.438 |
MOK |
0.637 | -0.044 | 1 | 0.557 |
CDK12 |
0.636 | -0.085 | 1 | 0.472 |
AKT3 |
0.636 | -0.021 | -3 | 0.492 |
STK33 |
0.635 | -0.126 | 2 | 0.693 |
ERK7 |
0.635 | -0.079 | 2 | 0.400 |
CDK9 |
0.634 | -0.100 | 1 | 0.500 |
CDK16 |
0.633 | -0.031 | 1 | 0.426 |
HASPIN |
0.632 | -0.086 | -1 | 0.663 |
PKG1 |
0.632 | 0.015 | -2 | 0.595 |
PKCI |
0.630 | -0.104 | 2 | 0.653 |
PKN1 |
0.630 | -0.057 | -3 | 0.560 |
PKCE |
0.627 | -0.087 | 2 | 0.628 |
YANK3 |
0.626 | -0.036 | 2 | 0.476 |
CDK4 |
0.626 | -0.093 | 1 | 0.461 |
CDK6 |
0.623 | -0.106 | 1 | 0.466 |
CDK10 |
0.616 | -0.090 | 1 | 0.460 |
YANK2 |
0.608 | -0.054 | 2 | 0.495 |
CK1G3 |
0.603 | -0.062 | -3 | 0.264 |
CK1A |
0.596 | -0.081 | -3 | 0.303 |
CK1G2 |
0.585 | -0.057 | -3 | 0.353 |