Motif 1212 (n=81)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A2RU30 | TESPA1 | S7 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
B4DJY2 | TMEM233 | S7 | ochoa | Transmembrane protein 233 (Dispanin subfamily B member 2) (DSPB2) (Interferon-induced transmembrane domain-containing protein D2) | Probable accessory protein of voltage-gated sodium channels. {ECO:0000269|PubMed:37117223}. |
B8ZZF3 | None | S7 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
O43251 | RBFOX2 | T7 | ochoa | RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity) | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). {ECO:0000250, ECO:0000269|PubMed:11875103, ECO:0000269|PubMed:37548402}. |
O43447 | PPIH | S7 | ochoa | Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:9570313}. |
O43524 | FOXO3 | S7 | ochoa|psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
O75382 | TRIM3 | S7 | ochoa | Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}. |
O95235 | KIF20A | S7 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95402 | MED26 | S7 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
O95817 | BAG3 | S7 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
P10301 | RRAS | S7 | ochoa | Ras-related protein R-Ras (EC 3.6.5.2) (p23) | GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:39809765}. |
P11086 | PNMT | S7 | ochoa | Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) | Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity). {ECO:0000250|UniProtKB:P10937, ECO:0000269|PubMed:16277617, ECO:0000269|PubMed:16363801, ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}. |
P15924 | DSP | S7 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P33991 | MCM4 | T7 | ochoa|psp | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
P35716 | SOX11 | S7 | ochoa | Transcription factor SOX-11 | Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}. |
P46019 | PHKA2 | S7 | ochoa | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
P46020 | PHKA1 | S7 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
P49450 | CENPA | S7 | psp | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}. |
P49753 | ACOT2 | S7 | ochoa | Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:10944470, PubMed:16940157). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}. |
P58005 | SESN3 | S7 | ochoa | Sestrin-3 (EC 1.11.1.-) | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000250|UniProtKB:Q9CYP7, ECO:0000269|PubMed:25263562}. |
Q01105 | SET | S7 | ochoa|psp | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
Q06330 | RBPJ | S7 | ochoa | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250|UniProtKB:P31266, ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}. |
Q13206 | DDX10 | S7 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
Q13283 | G3BP1 | S7 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
Q14161 | GIT2 | S7 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
Q14493 | SLBP | S7 | ochoa|psp | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
Q15544 | TAF11 | S7 | ochoa | Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473}. |
Q15788 | NCOA1 | S7 | ochoa | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
Q16537 | PPP2R5E | T7 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q4V339 | ZNG1F | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). {ECO:0000250|UniProtKB:Q8VEH6, ECO:0000269|PubMed:35584702}. |
Q52LA3 | LIN52 | S7 | psp | Protein lin-52 homolog | None |
Q5JSP0 | FGD3 | S7 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
Q5JTY5 | ZNG1C | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q5JVS0 | HABP4 | S7 | ochoa | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}. |
Q5RIA9 | ZNG1E | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q5UIP0 | RIF1 | S7 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q6P3V2 | ZNF585A | S7 | ochoa | Zinc finger protein 585A | May be involved in transcriptional regulation. |
Q86U38 | NOP9 | S7 | ochoa | Nucleolar protein 9 | None |
Q86UA6 | RPAIN | S7 | ochoa | RPA-interacting protein (hRIP) | Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. {ECO:0000269|PubMed:16135809}. |
Q86VQ0 | LCA5 | S7 | ochoa | Lebercilin (Leber congenital amaurosis 5 protein) | Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}. |
Q8IZW8 | TNS4 | S7 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
Q8N302 | AGGF1 | S7 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
Q8NBL1 | POGLUT1 | S7 | ochoa | Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63) | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYB9, ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:21490058, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:27807076, ECO:0000269|PubMed:28775322}. |
Q8NCH0 | CHST14 | T7 | ochoa | Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1) | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. {ECO:0000269|PubMed:19661164}. |
Q8NFU5 | IPMK | S7 | ochoa | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}. |
Q8NFZ5 | TNIP2 | S7 | ochoa | TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
Q8WTW3 | COG1 | S7 | ochoa | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | Required for normal Golgi function. {ECO:0000250}. |
Q8WUM0 | NUP133 | S7 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
Q8WVV9 | HNRNPLL | S7 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
Q8WZA1 | POMGNT1 | S7 | ochoa | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2) | Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191, ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613, ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216, ECO:0000269|PubMed:28512129}. |
Q969L2 | MAL2 | S7 | ochoa | Protein MAL2 | Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}. |
Q96A54 | ADIPOR1 | S7 | psp | Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I) | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. |
Q96DF8 | ESS2 | S7 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
Q96EC8 | YIPF6 | S7 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
Q96QK1 | VPS35 | S7 | ochoa | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. |
Q96SF7 | TBX15 | S7 | ochoa | T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14) | Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}. |
Q9BQ89 | FAM110A | S7 | ochoa | Protein FAM110A | None |
Q9BQC3 | DPH2 | S7 | ochoa | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}. |
Q9BRT8 | ZNG1A | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q9BRZ2 | TRIM56 | S7 | ochoa | E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160, ECO:0000269|PubMed:29426904, ECO:0000269|PubMed:31251739, ECO:0000269|PubMed:35952808}. |
Q9H4A4 | RNPEP | S7 | ochoa | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
Q9HBI1 | PARVB | S7 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
Q9NQC3 | RTN4 | S7 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
Q9NUP7 | TRMT13 | S7 | ochoa | tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) | tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}. |
Q9NZ45 | CISD1 | S7 | ochoa | CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET) | L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:17584744, PubMed:21788481, PubMed:23758282). {ECO:0000250, ECO:0000250|UniProtKB:Q91WS0, ECO:0000269|PubMed:17584744, ECO:0000269|PubMed:17766440, ECO:0000269|PubMed:21788481, ECO:0000269|PubMed:23758282, ECO:0000269|PubMed:36194135}. |
Q9UBY9 | HSPB7 | S7 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
Q9UH92 | MLX | S7 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
Q9UL45 | BLOC1S6 | S7 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}. |
Q9ULD5 | ZNF777 | S7 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
Q9UN86 | G3BP2 | S7 | ochoa | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:35977029}. |
Q9UPW6 | SATB2 | S7 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
Q9Y534 | CSDC2 | S7 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
Q9Y5S1 | TRPV2 | S7 | ochoa | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}. |
A1L429 | GAGE12B; | S7 | Sugiyama | G antigen 12B/C/D/E (GAGE-12B) (GAGE-12C) (GAGE-12D) (GAGE-12E) | None |
A6NDE8 | GAGE12H | S7 | Sugiyama | G antigen 12H (GAGE-12H) | None |
A6NER3 | GAGE12J | S7 | Sugiyama | G antigen 12J (GAGE-12J) | None |
O76087 | GAGE7 | S7 | Sugiyama | G antigen 7 (GAGE-7) (AL4) (Cancer/testis antigen 4.7) (CT4.7) (GAGE-12I) (GAGE-7B) (GAGE-8) | None |
P0CL80 | GAGE12F | S7 | Sugiyama | G antigen 12F (GAGE-12F) | None |
P0DSO3 | GAGE4 | S7 | Sugiyama | G antigen 4 (Cancer/testis antigen 4.4) (CT4.4) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:7544395}. |
Q13069 | GAGE5 | S7 | Sugiyama | G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5) | None |
Q13070 | GAGE6 | S7 | Sugiyama | G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6) | None |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 0.015712 | 1.804 |
R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.031181 | 1.506 |
R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.046409 | 1.333 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.056429 | 1.248 |
R-HSA-163765 | ChREBP activates metabolic gene expression | 0.071265 | 1.147 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.071265 | 1.147 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.071265 | 1.147 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.071265 | 1.147 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.076158 | 1.118 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.081027 | 1.091 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.081027 | 1.091 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.081027 | 1.091 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.081027 | 1.091 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.081027 | 1.091 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.081027 | 1.091 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.095480 | 1.020 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.019220 | 1.716 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.025915 | 1.586 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.123716 | 0.908 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.137506 | 0.862 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.013770 | 1.861 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.013770 | 1.861 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.173239 | 0.761 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.177601 | 0.751 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.177601 | 0.751 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.186258 | 0.730 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.186258 | 0.730 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.199075 | 0.701 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.215853 | 0.666 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.219994 | 0.658 |
R-HSA-167161 | HIV Transcription Initiation | 0.228209 | 0.642 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.228209 | 0.642 |
R-HSA-1989781 | PPARA activates gene expression | 0.232169 | 0.634 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.114403 | 0.942 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.082303 | 1.085 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.236058 | 0.627 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.173239 | 0.761 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.128337 | 0.892 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.173239 | 0.761 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.090688 | 1.042 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.132934 | 0.876 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.244385 | 0.612 |
R-HSA-389513 | Co-inhibition by CTLA4 | 0.123716 | 0.908 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.137506 | 0.862 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.244385 | 0.612 |
R-HSA-774815 | Nucleosome assembly | 0.244385 | 0.612 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.081027 | 1.091 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.041645 | 1.380 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.236339 | 0.626 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.228209 | 0.642 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.260225 | 0.585 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.071265 | 1.147 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.155559 | 0.808 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.021280 | 1.672 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.302114 | 0.520 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.302114 | 0.520 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.302114 | 0.520 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.302114 | 0.520 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.283372 | 0.548 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.109984 | 0.959 |
R-HSA-1538133 | G0 and Early G1 | 0.181941 | 0.740 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.026051 | 1.584 |
R-HSA-8932506 | DAG1 core M1 glycosylations | 0.051432 | 1.289 |
R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.051432 | 1.289 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.056429 | 1.248 |
R-HSA-176974 | Unwinding of DNA | 0.061400 | 1.212 |
R-HSA-4839744 | Signaling by APC mutants | 0.071265 | 1.147 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.076158 | 1.118 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.076158 | 1.118 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.181941 | 0.740 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.207508 | 0.683 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.244385 | 0.612 |
R-HSA-9843745 | Adipogenesis | 0.182216 | 0.739 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.228209 | 0.642 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.219994 | 0.658 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.219994 | 0.658 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.210014 | 0.678 |
R-HSA-1980145 | Signaling by NOTCH2 | 0.194825 | 0.710 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.041359 | 1.383 |
R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.090688 | 1.042 |
R-HSA-156711 | Polo-like kinase mediated events | 0.114403 | 0.942 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.190553 | 0.720 |
R-HSA-6811438 | Intra-Golgi traffic | 0.228209 | 0.642 |
R-HSA-193697 | p75NTR regulates axonogenesis | 0.061400 | 1.212 |
R-HSA-8932504 | DAG1 core M2 glycosylations | 0.056429 | 1.248 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.076158 | 1.118 |
R-HSA-191859 | snRNP Assembly | 0.298405 | 0.525 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.298405 | 0.525 |
R-HSA-9824272 | Somitogenesis | 0.244385 | 0.612 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.035017 | 1.456 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.256296 | 0.591 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.302114 | 0.520 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.095480 | 1.020 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.146580 | 0.834 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.061400 | 1.212 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.160014 | 0.796 |
R-HSA-180746 | Nuclear import of Rev protein | 0.194825 | 0.710 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.146580 | 0.834 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.146580 | 0.834 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.067224 | 1.172 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.061400 | 1.212 |
R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.061400 | 1.212 |
R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.076158 | 1.118 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.076158 | 1.118 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.100248 | 0.999 |
R-HSA-3238698 | WNT ligand biogenesis and trafficking | 0.137506 | 0.862 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.160014 | 0.796 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.219994 | 0.658 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.219994 | 0.658 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.224112 | 0.650 |
R-HSA-68949 | Orc1 removal from chromatin | 0.271890 | 0.566 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.072167 | 1.142 |
R-HSA-68882 | Mitotic Anaphase | 0.129325 | 0.888 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.130505 | 0.884 |
R-HSA-68877 | Mitotic Prometaphase | 0.102248 | 0.990 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.081027 | 1.091 |
R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.104991 | 0.979 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.186258 | 0.730 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.214731 | 0.668 |
R-HSA-983189 | Kinesins | 0.302114 | 0.520 |
R-HSA-2022923 | DS-GAG biosynthesis | 0.076158 | 1.118 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.026558 | 1.576 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.211692 | 0.674 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.248376 | 0.605 |
R-HSA-163685 | Integration of energy metabolism | 0.193612 | 0.713 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.160014 | 0.796 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.011901 | 1.924 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.109889 | 0.959 |
R-HSA-68886 | M Phase | 0.062445 | 1.204 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.139708 | 0.855 |
R-HSA-69206 | G1/S Transition | 0.169060 | 0.772 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.207022 | 0.684 |
R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.076158 | 1.118 |
R-HSA-209905 | Catecholamine biosynthesis | 0.109709 | 0.960 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.142055 | 0.848 |
R-HSA-5673000 | RAF activation | 0.194825 | 0.710 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.215853 | 0.666 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.290928 | 0.536 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.034545 | 1.462 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.111682 | 0.952 |
R-HSA-3295583 | TRP channels | 0.155559 | 0.808 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.120271 | 0.920 |
R-HSA-193648 | NRAGE signals death through JNK | 0.287160 | 0.542 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.035761 | 1.447 |
R-HSA-69190 | DNA strand elongation | 0.181941 | 0.740 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.100248 | 0.999 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.100248 | 0.999 |
R-HSA-1640170 | Cell Cycle | 0.090632 | 1.043 |
R-HSA-162587 | HIV Life Cycle | 0.236058 | 0.627 |
R-HSA-8931838 | DAG1 glycosylations | 0.181941 | 0.740 |
R-HSA-159418 | Recycling of bile acids and salts | 0.186258 | 0.730 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.146938 | 0.833 |
R-HSA-9033241 | Peroxisomal protein import | 0.298405 | 0.525 |
R-HSA-432142 | Platelet sensitization by LDL | 0.114403 | 0.942 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.173239 | 0.761 |
R-HSA-389356 | Co-stimulation by CD28 | 0.256296 | 0.591 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.056429 | 1.248 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.215853 | 0.666 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.248376 | 0.605 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.059997 | 1.222 |
R-HSA-9607240 | FLT3 Signaling | 0.224112 | 0.650 |
R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.128337 | 0.892 |
R-HSA-69242 | S Phase | 0.218596 | 0.660 |
R-HSA-68875 | Mitotic Prophase | 0.157924 | 0.802 |
R-HSA-877300 | Interferon gamma signaling | 0.239951 | 0.620 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.141508 | 0.849 |
R-HSA-1181150 | Signaling by NODAL | 0.123716 | 0.908 |
R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.160014 | 0.796 |
R-HSA-8875878 | MET promotes cell motility | 0.211692 | 0.674 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.115098 | 0.939 |
R-HSA-8982491 | Glycogen metabolism | 0.025915 | 1.586 |
R-HSA-199991 | Membrane Trafficking | 0.278546 | 0.555 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.151081 | 0.821 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.294676 | 0.531 |
R-HSA-69205 | G1/S-Specific Transcription | 0.203302 | 0.692 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.207508 | 0.683 |
R-HSA-3371556 | Cellular response to heat stress | 0.159770 | 0.797 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.053155 | 1.274 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.228209 | 0.642 |
R-HSA-1483191 | Synthesis of PC | 0.252346 | 0.598 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.142055 | 0.848 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.194825 | 0.710 |
R-HSA-72306 | tRNA processing | 0.263364 | 0.579 |
R-HSA-209776 | Metabolism of amine-derived hormones | 0.287160 | 0.542 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.143730 | 0.842 |
R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.244385 | 0.612 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.164445 | 0.784 |
R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.283372 | 0.548 |
R-HSA-186712 | Regulation of beta-cell development | 0.298405 | 0.525 |
R-HSA-73887 | Death Receptor Signaling | 0.230226 | 0.638 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.271890 | 0.566 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.203302 | 0.692 |
R-HSA-3781865 | Diseases of glycosylation | 0.290700 | 0.537 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.181941 | 0.740 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.243518 | 0.613 |
R-HSA-75153 | Apoptotic execution phase | 0.248376 | 0.605 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.305804 | 0.515 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.305804 | 0.515 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.305804 | 0.515 |
R-HSA-450294 | MAP kinase activation | 0.305804 | 0.515 |
R-HSA-211976 | Endogenous sterols | 0.305804 | 0.515 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.306279 | 0.514 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.309014 | 0.510 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.309474 | 0.509 |
R-HSA-9707616 | Heme signaling | 0.309474 | 0.509 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.313125 | 0.504 |
R-HSA-373755 | Semaphorin interactions | 0.313125 | 0.504 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.313913 | 0.503 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.320371 | 0.494 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.323965 | 0.490 |
R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.327541 | 0.485 |
R-HSA-167172 | Transcription of the HIV genome | 0.331098 | 0.480 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.338156 | 0.471 |
R-HSA-448424 | Interleukin-17 signaling | 0.338156 | 0.471 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.338156 | 0.471 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.338156 | 0.471 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.341657 | 0.466 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.345140 | 0.462 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.345140 | 0.462 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.345140 | 0.462 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.348605 | 0.458 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.348605 | 0.458 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.348605 | 0.458 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.352052 | 0.453 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.352052 | 0.453 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.355480 | 0.449 |
R-HSA-74160 | Gene expression (Transcription) | 0.357609 | 0.447 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.358891 | 0.445 |
R-HSA-913531 | Interferon Signaling | 0.359586 | 0.444 |
R-HSA-9679506 | SARS-CoV Infections | 0.361967 | 0.441 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.362284 | 0.441 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.365659 | 0.437 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.369017 | 0.433 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.372357 | 0.429 |
R-HSA-5654738 | Signaling by FGFR2 | 0.372357 | 0.429 |
R-HSA-6806834 | Signaling by MET | 0.372357 | 0.429 |
R-HSA-162906 | HIV Infection | 0.375349 | 0.426 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.375679 | 0.425 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.382272 | 0.418 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.388797 | 0.410 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.388797 | 0.410 |
R-HSA-8939211 | ESR-mediated signaling | 0.394086 | 0.404 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.395253 | 0.403 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.395253 | 0.403 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.395253 | 0.403 |
R-HSA-157118 | Signaling by NOTCH | 0.399659 | 0.398 |
R-HSA-9645723 | Diseases of programmed cell death | 0.401641 | 0.396 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.411099 | 0.386 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.419793 | 0.377 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.420410 | 0.376 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.423481 | 0.373 |
R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.426536 | 0.370 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.432598 | 0.364 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.432598 | 0.364 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.438596 | 0.358 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.438596 | 0.358 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.438596 | 0.358 |
R-HSA-190236 | Signaling by FGFR | 0.438596 | 0.358 |
R-HSA-9614085 | FOXO-mediated transcription | 0.441572 | 0.355 |
R-HSA-3214847 | HATs acetylate histones | 0.441572 | 0.355 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.441572 | 0.355 |
R-HSA-70171 | Glycolysis | 0.444532 | 0.352 |
R-HSA-5653656 | Vesicle-mediated transport | 0.446081 | 0.351 |
R-HSA-9020702 | Interleukin-1 signaling | 0.447477 | 0.349 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.447477 | 0.349 |
R-HSA-212436 | Generic Transcription Pathway | 0.451784 | 0.345 |
R-HSA-9833110 | RSV-host interactions | 0.459102 | 0.338 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.461970 | 0.335 |
R-HSA-418346 | Platelet homeostasis | 0.464823 | 0.333 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.464823 | 0.333 |
R-HSA-69239 | Synthesis of DNA | 0.467662 | 0.330 |
R-HSA-211000 | Gene Silencing by RNA | 0.467662 | 0.330 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.470485 | 0.327 |
R-HSA-2672351 | Stimuli-sensing channels | 0.470485 | 0.327 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.473294 | 0.325 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.473294 | 0.325 |
R-HSA-8953854 | Metabolism of RNA | 0.474061 | 0.324 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.475030 | 0.323 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.476088 | 0.322 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.476088 | 0.322 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.476088 | 0.322 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.484382 | 0.315 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.492546 | 0.308 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.497157 | 0.304 |
R-HSA-70326 | Glucose metabolism | 0.500583 | 0.301 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.500583 | 0.301 |
R-HSA-195721 | Signaling by WNT | 0.502190 | 0.299 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.503234 | 0.298 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.505871 | 0.296 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.505871 | 0.296 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.505871 | 0.296 |
R-HSA-73886 | Chromosome Maintenance | 0.511103 | 0.291 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.513699 | 0.289 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.513699 | 0.289 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.516281 | 0.287 |
R-HSA-2132295 | MHC class II antigen presentation | 0.516281 | 0.287 |
R-HSA-6809371 | Formation of the cornified envelope | 0.518849 | 0.285 |
R-HSA-162909 | Host Interactions of HIV factors | 0.518849 | 0.285 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.522935 | 0.282 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.523946 | 0.281 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.523946 | 0.281 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.523946 | 0.281 |
R-HSA-114608 | Platelet degranulation | 0.528989 | 0.277 |
R-HSA-69481 | G2/M Checkpoints | 0.528989 | 0.277 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.536455 | 0.270 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.543804 | 0.265 |
R-HSA-9909396 | Circadian clock | 0.543804 | 0.265 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.546228 | 0.263 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.555797 | 0.255 |
R-HSA-5173105 | O-linked glycosylation | 0.558158 | 0.253 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.558158 | 0.253 |
R-HSA-9824446 | Viral Infection Pathways | 0.570127 | 0.244 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.572247 | 0.242 |
R-HSA-5683057 | MAPK family signaling cascades | 0.579750 | 0.237 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.583325 | 0.234 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.585541 | 0.232 |
R-HSA-9758941 | Gastrulation | 0.587746 | 0.231 |
R-HSA-446652 | Interleukin-1 family signaling | 0.594291 | 0.226 |
R-HSA-69306 | DNA Replication | 0.596449 | 0.224 |
R-HSA-9609507 | Protein localization | 0.596449 | 0.224 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.596449 | 0.224 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.598597 | 0.223 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.598597 | 0.223 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.600733 | 0.221 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.603121 | 0.220 |
R-HSA-9610379 | HCMV Late Events | 0.604971 | 0.218 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.611246 | 0.214 |
R-HSA-109581 | Apoptosis | 0.615374 | 0.211 |
R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.625506 | 0.204 |
R-HSA-5619102 | SLC transporter disorders | 0.625506 | 0.204 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.643083 | 0.192 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.643083 | 0.192 |
R-HSA-168255 | Influenza Infection | 0.650631 | 0.187 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.658021 | 0.182 |
R-HSA-69275 | G2/M Transition | 0.663462 | 0.178 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.667041 | 0.176 |
R-HSA-449147 | Signaling by Interleukins | 0.667715 | 0.175 |
R-HSA-983712 | Ion channel transport | 0.668817 | 0.175 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.672341 | 0.172 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.675827 | 0.170 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.677556 | 0.169 |
R-HSA-9609690 | HCMV Early Events | 0.680988 | 0.167 |
R-HSA-5668914 | Diseases of metabolism | 0.688084 | 0.162 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.691067 | 0.160 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.692716 | 0.159 |
R-HSA-72172 | mRNA Splicing | 0.695988 | 0.157 |
R-HSA-5357801 | Programmed Cell Death | 0.697611 | 0.156 |
R-HSA-6805567 | Keratinization | 0.699226 | 0.155 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.741130 | 0.130 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.758571 | 0.120 |
R-HSA-162582 | Signal Transduction | 0.759241 | 0.120 |
R-HSA-4839726 | Chromatin organization | 0.761149 | 0.119 |
R-HSA-9609646 | HCMV Infection | 0.762428 | 0.118 |
R-HSA-5688426 | Deubiquitination | 0.768721 | 0.114 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.769960 | 0.114 |
R-HSA-9711123 | Cellular response to chemical stress | 0.784323 | 0.106 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.791168 | 0.102 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.795612 | 0.099 |
R-HSA-446728 | Cell junction organization | 0.795612 | 0.099 |
R-HSA-597592 | Post-translational protein modification | 0.795862 | 0.099 |
R-HSA-109582 | Hemostasis | 0.803571 | 0.095 |
R-HSA-2262752 | Cellular responses to stress | 0.805911 | 0.094 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.807357 | 0.093 |
R-HSA-1483257 | Phospholipid metabolism | 0.813479 | 0.090 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.814481 | 0.089 |
R-HSA-1500931 | Cell-Cell communication | 0.833431 | 0.079 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.836985 | 0.077 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.839601 | 0.076 |
R-HSA-8957322 | Metabolism of steroids | 0.840464 | 0.075 |
R-HSA-1643685 | Disease | 0.844890 | 0.073 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.852479 | 0.069 |
R-HSA-73894 | DNA Repair | 0.868649 | 0.061 |
R-HSA-8953897 | Cellular responses to stimuli | 0.871696 | 0.060 |
R-HSA-8978868 | Fatty acid metabolism | 0.898711 | 0.046 |
R-HSA-5663205 | Infectious disease | 0.899673 | 0.046 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.906627 | 0.043 |
R-HSA-6798695 | Neutrophil degranulation | 0.922799 | 0.035 |
R-HSA-168256 | Immune System | 0.939619 | 0.027 |
R-HSA-211859 | Biological oxidations | 0.946128 | 0.024 |
R-HSA-422475 | Axon guidance | 0.952233 | 0.021 |
R-HSA-392499 | Metabolism of proteins | 0.954311 | 0.020 |
R-HSA-1266738 | Developmental Biology | 0.956432 | 0.019 |
R-HSA-9675108 | Nervous system development | 0.960995 | 0.017 |
R-HSA-556833 | Metabolism of lipids | 0.963353 | 0.016 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.967990 | 0.014 |
R-HSA-168249 | Innate Immune System | 0.977346 | 0.010 |
R-HSA-1280218 | Adaptive Immune System | 0.979287 | 0.009 |
R-HSA-388396 | GPCR downstream signalling | 0.986480 | 0.006 |
R-HSA-1430728 | Metabolism | 0.987832 | 0.005 |
R-HSA-372790 | Signaling by GPCR | 0.991483 | 0.004 |
R-HSA-382551 | Transport of small molecules | 0.995750 | 0.002 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.829 | 0.728 | 1 | 0.856 |
CDK18 |
0.816 | 0.692 | 1 | 0.859 |
CDK19 |
0.816 | 0.680 | 1 | 0.869 |
P38G |
0.813 | 0.708 | 1 | 0.867 |
DYRK2 |
0.812 | 0.694 | 1 | 0.820 |
CDK8 |
0.811 | 0.672 | 1 | 0.850 |
KIS |
0.810 | 0.610 | 1 | 0.833 |
DYRK4 |
0.809 | 0.685 | 1 | 0.862 |
CDK12 |
0.808 | 0.702 | 1 | 0.855 |
HIPK1 |
0.808 | 0.679 | 1 | 0.817 |
JNK2 |
0.808 | 0.708 | 1 | 0.859 |
CLK3 |
0.808 | 0.506 | 1 | 0.645 |
SRPK1 |
0.807 | 0.491 | -3 | 0.846 |
CDK13 |
0.807 | 0.688 | 1 | 0.848 |
CDK17 |
0.807 | 0.679 | 1 | 0.852 |
HIPK4 |
0.807 | 0.551 | 1 | 0.675 |
CDK7 |
0.805 | 0.667 | 1 | 0.841 |
CDK1 |
0.805 | 0.652 | 1 | 0.837 |
CDK3 |
0.803 | 0.593 | 1 | 0.855 |
ERK1 |
0.803 | 0.674 | 1 | 0.868 |
P38D |
0.803 | 0.684 | 1 | 0.870 |
JNK3 |
0.802 | 0.696 | 1 | 0.842 |
P38B |
0.802 | 0.677 | 1 | 0.853 |
MAK |
0.800 | 0.590 | -2 | 0.791 |
DYRK1A |
0.800 | 0.640 | 1 | 0.793 |
CDK5 |
0.800 | 0.646 | 1 | 0.829 |
DYRK1B |
0.799 | 0.660 | 1 | 0.836 |
CDK16 |
0.798 | 0.647 | 1 | 0.851 |
P38A |
0.798 | 0.675 | 1 | 0.830 |
CDK9 |
0.797 | 0.663 | 1 | 0.852 |
HIPK3 |
0.797 | 0.665 | 1 | 0.809 |
CDK14 |
0.797 | 0.676 | 1 | 0.842 |
CLK2 |
0.797 | 0.493 | -3 | 0.843 |
CDK10 |
0.796 | 0.657 | 1 | 0.847 |
SRPK2 |
0.795 | 0.428 | -3 | 0.806 |
DYRK3 |
0.791 | 0.570 | 1 | 0.790 |
JNK1 |
0.790 | 0.644 | 1 | 0.839 |
NLK |
0.789 | 0.617 | 1 | 0.693 |
ICK |
0.789 | 0.492 | -3 | 0.861 |
CLK1 |
0.788 | 0.496 | -3 | 0.821 |
CLK4 |
0.788 | 0.462 | -3 | 0.838 |
CDKL5 |
0.787 | 0.349 | -3 | 0.853 |
SRPK3 |
0.785 | 0.395 | -3 | 0.813 |
CDK4 |
0.784 | 0.668 | 1 | 0.856 |
ERK2 |
0.784 | 0.640 | 1 | 0.842 |
CDK6 |
0.781 | 0.636 | 1 | 0.857 |
CDKL1 |
0.781 | 0.343 | -3 | 0.847 |
ERK5 |
0.779 | 0.346 | 1 | 0.640 |
MOK |
0.777 | 0.533 | 1 | 0.747 |
COT |
0.776 | 0.028 | 2 | 0.841 |
MTOR |
0.776 | 0.242 | 1 | 0.502 |
CDK2 |
0.771 | 0.468 | 1 | 0.771 |
PRP4 |
0.769 | 0.413 | -3 | 0.709 |
PIM3 |
0.768 | 0.129 | -3 | 0.865 |
PRKD1 |
0.767 | 0.143 | -3 | 0.876 |
SKMLCK |
0.767 | 0.127 | -2 | 0.820 |
NDR2 |
0.766 | 0.096 | -3 | 0.847 |
RSK3 |
0.765 | 0.171 | -3 | 0.851 |
P90RSK |
0.765 | 0.187 | -3 | 0.857 |
RSK2 |
0.764 | 0.171 | -3 | 0.848 |
CAMK1B |
0.763 | 0.156 | -3 | 0.838 |
PIM1 |
0.763 | 0.176 | -3 | 0.853 |
MOS |
0.762 | 0.025 | 1 | 0.395 |
PRKD2 |
0.761 | 0.151 | -3 | 0.853 |
PRPK |
0.760 | -0.007 | -1 | 0.676 |
NDR1 |
0.760 | 0.079 | -3 | 0.848 |
NUAK2 |
0.760 | 0.145 | -3 | 0.852 |
MARK4 |
0.759 | 0.083 | 4 | 0.767 |
WNK1 |
0.758 | 0.082 | -2 | 0.853 |
PKN3 |
0.758 | 0.094 | -3 | 0.839 |
MAPKAPK2 |
0.758 | 0.146 | -3 | 0.845 |
CDC7 |
0.758 | -0.043 | 1 | 0.332 |
PKACG |
0.758 | 0.099 | -2 | 0.687 |
CHAK2 |
0.757 | 0.034 | -1 | 0.683 |
PKCD |
0.757 | 0.093 | 2 | 0.728 |
ATR |
0.757 | -0.004 | 1 | 0.388 |
MAPKAPK3 |
0.756 | 0.124 | -3 | 0.854 |
PKACB |
0.756 | 0.149 | -2 | 0.626 |
MST4 |
0.756 | 0.041 | 2 | 0.779 |
RAF1 |
0.756 | -0.077 | 1 | 0.356 |
AURC |
0.755 | 0.106 | -2 | 0.619 |
TBK1 |
0.755 | -0.098 | 1 | 0.317 |
PAK1 |
0.755 | 0.091 | -2 | 0.736 |
AKT2 |
0.754 | 0.202 | -3 | 0.807 |
CAMLCK |
0.753 | 0.108 | -2 | 0.787 |
AMPKA1 |
0.753 | 0.079 | -3 | 0.852 |
DAPK2 |
0.753 | 0.125 | -3 | 0.836 |
PKN2 |
0.753 | 0.064 | -3 | 0.830 |
SGK3 |
0.753 | 0.168 | -3 | 0.839 |
CAMK2D |
0.753 | 0.069 | -3 | 0.831 |
DCAMKL1 |
0.752 | 0.167 | -3 | 0.852 |
NIK |
0.752 | 0.078 | -3 | 0.817 |
RSK4 |
0.752 | 0.152 | -3 | 0.834 |
MSK2 |
0.752 | 0.139 | -3 | 0.848 |
TSSK1 |
0.752 | 0.095 | -3 | 0.859 |
IKKB |
0.752 | -0.106 | -2 | 0.635 |
CAMK2G |
0.752 | -0.016 | 2 | 0.828 |
QSK |
0.752 | 0.114 | 4 | 0.761 |
PRKD3 |
0.751 | 0.157 | -3 | 0.834 |
CAMK2A |
0.751 | 0.114 | 2 | 0.806 |
LATS2 |
0.751 | 0.044 | -5 | 0.554 |
PRKX |
0.751 | 0.163 | -3 | 0.799 |
PDHK4 |
0.750 | -0.118 | 1 | 0.422 |
ULK2 |
0.750 | -0.120 | 2 | 0.750 |
PAK3 |
0.750 | 0.057 | -2 | 0.727 |
PKCG |
0.750 | 0.082 | 2 | 0.681 |
PKCB |
0.750 | 0.082 | 2 | 0.657 |
IKKE |
0.750 | -0.125 | 1 | 0.306 |
NIM1 |
0.750 | 0.063 | 3 | 0.720 |
P70S6KB |
0.749 | 0.109 | -3 | 0.840 |
AMPKA2 |
0.749 | 0.092 | -3 | 0.848 |
GCN2 |
0.749 | -0.155 | 2 | 0.767 |
PDHK1 |
0.748 | -0.117 | 1 | 0.403 |
NEK6 |
0.748 | -0.059 | -2 | 0.776 |
PKCZ |
0.748 | 0.070 | 2 | 0.716 |
BCKDK |
0.748 | -0.065 | -1 | 0.627 |
BMPR2 |
0.748 | -0.152 | -2 | 0.785 |
IRE1 |
0.747 | 0.005 | 1 | 0.375 |
MSK1 |
0.747 | 0.129 | -3 | 0.849 |
MNK2 |
0.746 | 0.061 | -2 | 0.748 |
ERK7 |
0.746 | 0.215 | 2 | 0.495 |
SIK |
0.746 | 0.116 | -3 | 0.824 |
LATS1 |
0.746 | 0.081 | -3 | 0.843 |
PKCA |
0.746 | 0.071 | 2 | 0.650 |
HUNK |
0.745 | -0.059 | 2 | 0.786 |
MNK1 |
0.745 | 0.075 | -2 | 0.746 |
CAMK2B |
0.745 | 0.062 | 2 | 0.796 |
DSTYK |
0.745 | -0.145 | 2 | 0.806 |
TSSK2 |
0.744 | 0.024 | -5 | 0.657 |
PKG2 |
0.744 | 0.094 | -2 | 0.633 |
RIPK3 |
0.744 | -0.084 | 3 | 0.688 |
MASTL |
0.744 | -0.085 | -2 | 0.741 |
GRK1 |
0.744 | -0.024 | -2 | 0.667 |
IKKA |
0.743 | -0.085 | -2 | 0.627 |
NUAK1 |
0.743 | 0.089 | -3 | 0.829 |
AKT1 |
0.743 | 0.164 | -3 | 0.818 |
PKACA |
0.743 | 0.140 | -2 | 0.584 |
PIM2 |
0.742 | 0.158 | -3 | 0.829 |
MARK3 |
0.742 | 0.073 | 4 | 0.720 |
PHKG1 |
0.742 | 0.046 | -3 | 0.846 |
WNK3 |
0.742 | -0.099 | 1 | 0.378 |
QIK |
0.742 | 0.039 | -3 | 0.810 |
NEK7 |
0.742 | -0.157 | -3 | 0.707 |
PINK1 |
0.742 | 0.144 | 1 | 0.541 |
MAPKAPK5 |
0.741 | 0.110 | -3 | 0.818 |
MELK |
0.741 | 0.069 | -3 | 0.838 |
GRK7 |
0.740 | 0.012 | 1 | 0.347 |
MLK2 |
0.740 | -0.083 | 2 | 0.757 |
PAK2 |
0.740 | 0.029 | -2 | 0.714 |
TGFBR2 |
0.740 | -0.077 | -2 | 0.679 |
MLK1 |
0.740 | -0.130 | 2 | 0.734 |
BRSK1 |
0.739 | 0.075 | -3 | 0.845 |
VRK2 |
0.739 | 0.135 | 1 | 0.486 |
MARK2 |
0.739 | 0.058 | 4 | 0.694 |
MPSK1 |
0.739 | 0.110 | 1 | 0.443 |
GRK5 |
0.739 | -0.144 | -3 | 0.721 |
AKT3 |
0.738 | 0.187 | -3 | 0.791 |
DLK |
0.738 | -0.117 | 1 | 0.382 |
PKCH |
0.738 | 0.045 | 2 | 0.643 |
NEK9 |
0.738 | -0.131 | 2 | 0.773 |
SGK1 |
0.738 | 0.208 | -3 | 0.774 |
RIPK1 |
0.737 | -0.088 | 1 | 0.370 |
ATM |
0.737 | -0.065 | 1 | 0.322 |
SBK |
0.737 | 0.268 | -3 | 0.742 |
DCAMKL2 |
0.737 | 0.117 | -3 | 0.840 |
AURB |
0.737 | 0.058 | -2 | 0.611 |
GSK3A |
0.737 | 0.147 | 4 | 0.310 |
ULK1 |
0.736 | -0.151 | -3 | 0.682 |
MLK3 |
0.736 | -0.053 | 2 | 0.673 |
WNK4 |
0.736 | 0.063 | -2 | 0.868 |
PAK6 |
0.736 | 0.046 | -2 | 0.655 |
PKCT |
0.735 | 0.074 | 2 | 0.655 |
BMPR1B |
0.735 | -0.042 | 1 | 0.316 |
ANKRD3 |
0.735 | -0.123 | 1 | 0.396 |
MYLK4 |
0.735 | 0.076 | -2 | 0.705 |
PKR |
0.735 | -0.020 | 1 | 0.396 |
DNAPK |
0.735 | -0.027 | 1 | 0.309 |
GRK6 |
0.735 | -0.107 | 1 | 0.345 |
TTBK2 |
0.735 | -0.099 | 2 | 0.749 |
IRE2 |
0.734 | -0.038 | 2 | 0.693 |
TLK2 |
0.734 | -0.061 | 1 | 0.336 |
CAMK1G |
0.734 | 0.105 | -3 | 0.815 |
AURA |
0.734 | 0.035 | -2 | 0.578 |
BRSK2 |
0.734 | 0.019 | -3 | 0.829 |
CAMK4 |
0.734 | -0.020 | -3 | 0.821 |
SMG1 |
0.733 | -0.057 | 1 | 0.361 |
NEK2 |
0.733 | -0.068 | 2 | 0.750 |
PASK |
0.733 | 0.084 | -3 | 0.851 |
CHK1 |
0.732 | 0.009 | -3 | 0.838 |
ALK4 |
0.732 | -0.057 | -2 | 0.729 |
CHAK1 |
0.732 | -0.072 | 2 | 0.732 |
FAM20C |
0.732 | -0.025 | 2 | 0.560 |
MEK1 |
0.731 | -0.094 | 2 | 0.806 |
PKCI |
0.731 | 0.069 | 2 | 0.681 |
TGFBR1 |
0.731 | -0.056 | -2 | 0.695 |
PKCE |
0.730 | 0.106 | 2 | 0.652 |
TAO3 |
0.730 | 0.018 | 1 | 0.378 |
PLK4 |
0.730 | -0.071 | 2 | 0.637 |
MST3 |
0.729 | 0.004 | 2 | 0.757 |
MARK1 |
0.729 | 0.023 | 4 | 0.730 |
SSTK |
0.729 | 0.048 | 4 | 0.752 |
PAK5 |
0.729 | 0.047 | -2 | 0.592 |
CK1E |
0.728 | -0.011 | -3 | 0.459 |
BRAF |
0.728 | -0.022 | -4 | 0.889 |
MLK4 |
0.728 | -0.092 | 2 | 0.659 |
CAMK1D |
0.727 | 0.125 | -3 | 0.796 |
PAK4 |
0.727 | 0.056 | -2 | 0.598 |
NEK5 |
0.727 | -0.061 | 1 | 0.391 |
DAPK3 |
0.726 | 0.107 | -3 | 0.846 |
MEKK1 |
0.726 | -0.092 | 1 | 0.391 |
PLK1 |
0.726 | -0.129 | -2 | 0.674 |
MEKK2 |
0.726 | -0.060 | 2 | 0.751 |
LKB1 |
0.725 | 0.029 | -3 | 0.737 |
PKN1 |
0.725 | 0.109 | -3 | 0.813 |
YSK4 |
0.725 | -0.161 | 1 | 0.329 |
P70S6K |
0.725 | 0.093 | -3 | 0.805 |
MEK5 |
0.724 | -0.090 | 2 | 0.769 |
PDK1 |
0.724 | 0.066 | 1 | 0.375 |
GRK4 |
0.724 | -0.187 | -2 | 0.707 |
SMMLCK |
0.724 | 0.080 | -3 | 0.828 |
PBK |
0.724 | 0.073 | 1 | 0.429 |
DRAK1 |
0.724 | -0.079 | 1 | 0.273 |
SNRK |
0.723 | -0.059 | 2 | 0.647 |
CK1G1 |
0.723 | -0.021 | -3 | 0.437 |
IRAK4 |
0.722 | -0.056 | 1 | 0.381 |
ZAK |
0.722 | -0.116 | 1 | 0.356 |
PHKG2 |
0.722 | 0.020 | -3 | 0.810 |
HASPIN |
0.721 | 0.160 | -1 | 0.703 |
ROCK2 |
0.721 | 0.118 | -3 | 0.843 |
MEKK6 |
0.721 | 0.014 | 1 | 0.403 |
PLK3 |
0.721 | -0.097 | 2 | 0.790 |
MRCKB |
0.720 | 0.122 | -3 | 0.811 |
CK1D |
0.720 | -0.005 | -3 | 0.407 |
ACVR2A |
0.720 | -0.112 | -2 | 0.662 |
ALK2 |
0.720 | -0.095 | -2 | 0.698 |
ACVR2B |
0.720 | -0.117 | -2 | 0.672 |
DAPK1 |
0.720 | 0.104 | -3 | 0.838 |
CHK2 |
0.720 | 0.149 | -3 | 0.778 |
MAP3K15 |
0.719 | -0.001 | 1 | 0.362 |
TNIK |
0.719 | 0.033 | 3 | 0.820 |
GCK |
0.719 | -0.013 | 1 | 0.359 |
KHS1 |
0.718 | 0.051 | 1 | 0.352 |
MEKK3 |
0.718 | -0.147 | 1 | 0.375 |
GSK3B |
0.718 | 0.015 | 4 | 0.306 |
CK1A2 |
0.718 | -0.013 | -3 | 0.416 |
HGK |
0.717 | 0.004 | 3 | 0.809 |
BUB1 |
0.717 | 0.070 | -5 | 0.572 |
GAK |
0.717 | 0.003 | 1 | 0.449 |
TAO2 |
0.717 | -0.017 | 2 | 0.777 |
GRK2 |
0.716 | -0.101 | -2 | 0.605 |
STK33 |
0.716 | 0.006 | 2 | 0.688 |
TLK1 |
0.716 | -0.130 | -2 | 0.708 |
CAMK1A |
0.715 | 0.126 | -3 | 0.784 |
KHS2 |
0.715 | 0.063 | 1 | 0.359 |
HPK1 |
0.715 | 0.001 | 1 | 0.344 |
LRRK2 |
0.714 | 0.061 | 2 | 0.790 |
DMPK1 |
0.714 | 0.145 | -3 | 0.815 |
PERK |
0.713 | -0.165 | -2 | 0.719 |
BMPR1A |
0.713 | -0.079 | 1 | 0.295 |
MINK |
0.713 | -0.041 | 1 | 0.354 |
NEK8 |
0.713 | -0.104 | 2 | 0.751 |
NEK11 |
0.713 | -0.110 | 1 | 0.359 |
CAMKK2 |
0.713 | -0.091 | -2 | 0.665 |
PKG1 |
0.712 | 0.088 | -2 | 0.564 |
HRI |
0.712 | -0.178 | -2 | 0.743 |
MRCKA |
0.711 | 0.079 | -3 | 0.815 |
NEK4 |
0.711 | -0.101 | 1 | 0.368 |
CRIK |
0.709 | 0.139 | -3 | 0.822 |
LOK |
0.709 | -0.039 | -2 | 0.691 |
CAMKK1 |
0.709 | -0.155 | -2 | 0.655 |
NEK1 |
0.708 | -0.078 | 1 | 0.377 |
CK2A2 |
0.708 | -0.044 | 1 | 0.238 |
ROCK1 |
0.707 | 0.104 | -3 | 0.823 |
TTBK1 |
0.706 | -0.106 | 2 | 0.705 |
EEF2K |
0.706 | -0.038 | 3 | 0.808 |
YSK1 |
0.706 | -0.040 | 2 | 0.735 |
GRK3 |
0.705 | -0.096 | -2 | 0.560 |
SLK |
0.704 | -0.065 | -2 | 0.626 |
MST2 |
0.704 | -0.154 | 1 | 0.356 |
YANK3 |
0.703 | 0.050 | 2 | 0.542 |
VRK1 |
0.702 | -0.074 | 2 | 0.792 |
IRAK1 |
0.702 | -0.193 | -1 | 0.566 |
NEK3 |
0.702 | -0.047 | 1 | 0.395 |
OSR1 |
0.700 | -0.045 | 2 | 0.757 |
PLK2 |
0.700 | -0.049 | -3 | 0.664 |
CK2A1 |
0.697 | -0.056 | 1 | 0.222 |
TAK1 |
0.697 | -0.175 | 1 | 0.348 |
MYO3B |
0.696 | -0.009 | 2 | 0.755 |
MST1 |
0.695 | -0.163 | 1 | 0.344 |
MEK2 |
0.694 | -0.165 | 2 | 0.767 |
TAO1 |
0.694 | -0.033 | 1 | 0.338 |
ASK1 |
0.693 | -0.058 | 1 | 0.347 |
RIPK2 |
0.689 | -0.189 | 1 | 0.313 |
BIKE |
0.689 | -0.009 | 1 | 0.422 |
CK1A |
0.688 | -0.024 | -3 | 0.324 |
MYO3A |
0.687 | -0.066 | 1 | 0.358 |
TTK |
0.687 | -0.097 | -2 | 0.697 |
AAK1 |
0.686 | 0.035 | 1 | 0.407 |
PDHK3_TYR |
0.684 | 0.152 | 4 | 0.794 |
LIMK2_TYR |
0.683 | 0.190 | -3 | 0.798 |
PKMYT1_TYR |
0.681 | 0.197 | 3 | 0.792 |
MAP2K4_TYR |
0.678 | 0.073 | -1 | 0.698 |
TESK1_TYR |
0.677 | 0.080 | 3 | 0.820 |
PDHK4_TYR |
0.676 | 0.055 | 2 | 0.830 |
MAP2K6_TYR |
0.675 | 0.042 | -1 | 0.711 |
ALPHAK3 |
0.674 | -0.128 | -1 | 0.580 |
BMPR2_TYR |
0.672 | 0.026 | -1 | 0.711 |
STLK3 |
0.672 | -0.167 | 1 | 0.330 |
MAP2K7_TYR |
0.672 | -0.014 | 2 | 0.812 |
PDHK1_TYR |
0.672 | -0.004 | -1 | 0.699 |
CK1G3 |
0.671 | -0.014 | -3 | 0.280 |
LIMK1_TYR |
0.669 | 0.046 | 2 | 0.800 |
YANK2 |
0.669 | 0.009 | 2 | 0.551 |
PINK1_TYR |
0.668 | -0.045 | 1 | 0.415 |
RET |
0.663 | -0.108 | 1 | 0.398 |
MST1R |
0.663 | -0.069 | 3 | 0.756 |
TNNI3K_TYR |
0.663 | 0.018 | 1 | 0.463 |
EPHA6 |
0.663 | -0.045 | -1 | 0.653 |
DDR1 |
0.662 | -0.060 | 4 | 0.736 |
TNK1 |
0.661 | 0.035 | 3 | 0.714 |
TNK2 |
0.661 | -0.015 | 3 | 0.703 |
EPHB4 |
0.660 | -0.075 | -1 | 0.617 |
CSF1R |
0.660 | -0.081 | 3 | 0.728 |
ROS1 |
0.660 | -0.097 | 3 | 0.690 |
JAK2 |
0.659 | -0.120 | 1 | 0.417 |
FGR |
0.657 | -0.127 | 1 | 0.419 |
TYRO3 |
0.657 | -0.129 | 3 | 0.723 |
JAK3 |
0.656 | -0.108 | 1 | 0.373 |
MET |
0.656 | -0.055 | 3 | 0.726 |
DDR2 |
0.656 | 0.023 | 3 | 0.663 |
TYK2 |
0.656 | -0.197 | 1 | 0.390 |
ABL2 |
0.655 | -0.097 | -1 | 0.584 |
BLK |
0.655 | -0.049 | -1 | 0.627 |
LCK |
0.655 | -0.066 | -1 | 0.614 |
FGFR2 |
0.654 | -0.060 | 3 | 0.731 |
KDR |
0.654 | -0.066 | 3 | 0.700 |
YES1 |
0.654 | -0.111 | -1 | 0.622 |
NEK10_TYR |
0.653 | -0.080 | 1 | 0.309 |
TXK |
0.652 | -0.088 | 1 | 0.377 |
ABL1 |
0.652 | -0.109 | -1 | 0.566 |
FGFR1 |
0.652 | -0.059 | 3 | 0.695 |
EPHA4 |
0.651 | -0.056 | 2 | 0.789 |
HCK |
0.651 | -0.125 | -1 | 0.608 |
CK1G2 |
0.651 | -0.024 | -3 | 0.362 |
ITK |
0.650 | -0.106 | -1 | 0.572 |
PDGFRB |
0.650 | -0.151 | 3 | 0.733 |
JAK1 |
0.649 | -0.097 | 1 | 0.361 |
INSRR |
0.648 | -0.146 | 3 | 0.678 |
KIT |
0.648 | -0.132 | 3 | 0.733 |
FER |
0.647 | -0.204 | 1 | 0.400 |
FGFR3 |
0.645 | -0.075 | 3 | 0.710 |
EPHB3 |
0.645 | -0.138 | -1 | 0.595 |
FYN |
0.644 | -0.076 | -1 | 0.607 |
EPHB1 |
0.644 | -0.163 | 1 | 0.362 |
TEK |
0.644 | -0.083 | 3 | 0.665 |
FLT1 |
0.644 | -0.119 | -1 | 0.631 |
SRMS |
0.644 | -0.178 | 1 | 0.364 |
MERTK |
0.644 | -0.133 | 3 | 0.721 |
EPHB2 |
0.643 | -0.139 | -1 | 0.587 |
BMX |
0.643 | -0.105 | -1 | 0.513 |
FLT3 |
0.642 | -0.184 | 3 | 0.738 |
EPHA7 |
0.642 | -0.088 | 2 | 0.787 |
PTK2 |
0.641 | -0.003 | -1 | 0.625 |
EPHA1 |
0.641 | -0.111 | 3 | 0.717 |
AXL |
0.641 | -0.156 | 3 | 0.705 |
INSR |
0.640 | -0.143 | 3 | 0.669 |
PDGFRA |
0.639 | -0.194 | 3 | 0.726 |
ERBB2 |
0.639 | -0.150 | 1 | 0.344 |
EPHA3 |
0.638 | -0.104 | 2 | 0.765 |
WEE1_TYR |
0.638 | -0.093 | -1 | 0.539 |
PTK2B |
0.638 | -0.082 | -1 | 0.525 |
NTRK3 |
0.638 | -0.146 | -1 | 0.570 |
EGFR |
0.637 | -0.093 | 1 | 0.306 |
NTRK1 |
0.637 | -0.202 | -1 | 0.604 |
PTK6 |
0.637 | -0.184 | -1 | 0.488 |
FRK |
0.637 | -0.141 | -1 | 0.615 |
FLT4 |
0.636 | -0.149 | 3 | 0.696 |
SRC |
0.636 | -0.116 | -1 | 0.586 |
LTK |
0.636 | -0.163 | 3 | 0.673 |
FGFR4 |
0.635 | -0.086 | -1 | 0.544 |
EPHA8 |
0.635 | -0.089 | -1 | 0.598 |
MATK |
0.635 | -0.111 | -1 | 0.522 |
ALK |
0.634 | -0.180 | 3 | 0.641 |
NTRK2 |
0.634 | -0.212 | 3 | 0.689 |
TEC |
0.633 | -0.176 | -1 | 0.488 |
LYN |
0.633 | -0.151 | 3 | 0.667 |
CSK |
0.633 | -0.104 | 2 | 0.799 |
BTK |
0.632 | -0.234 | -1 | 0.526 |
ERBB4 |
0.630 | -0.071 | 1 | 0.300 |
SYK |
0.628 | -0.088 | -1 | 0.605 |
EPHA5 |
0.628 | -0.144 | 2 | 0.759 |
EPHA2 |
0.627 | -0.099 | -1 | 0.568 |
IGF1R |
0.622 | -0.149 | 3 | 0.611 |
ZAP70 |
0.622 | -0.060 | -1 | 0.553 |
MUSK |
0.620 | -0.155 | 1 | 0.280 |
FES |
0.602 | -0.181 | -1 | 0.468 |