Motif 1212 (n=81)

Position-wise Probabilities

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uniprot genes site source protein function
A2RU30 TESPA1 S7 ochoa Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}.
B4DJY2 TMEM233 S7 ochoa Transmembrane protein 233 (Dispanin subfamily B member 2) (DSPB2) (Interferon-induced transmembrane domain-containing protein D2) Probable accessory protein of voltage-gated sodium channels. {ECO:0000269|PubMed:37117223}.
B8ZZF3 None S7 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
O43251 RBFOX2 T7 ochoa RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity) RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). {ECO:0000250, ECO:0000269|PubMed:11875103, ECO:0000269|PubMed:37548402}.
O43447 PPIH S7 ochoa Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:9570313}.
O43524 FOXO3 S7 ochoa|psp Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O75382 TRIM3 S7 ochoa Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}.
O95235 KIF20A S7 ochoa|psp Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95402 MED26 S7 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95817 BAG3 S7 ochoa BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}.
P10301 RRAS S7 ochoa Ras-related protein R-Ras (EC 3.6.5.2) (p23) GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:39809765}.
P11086 PNMT S7 ochoa Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity). {ECO:0000250|UniProtKB:P10937, ECO:0000269|PubMed:16277617, ECO:0000269|PubMed:16363801, ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}.
P15924 DSP S7 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P33991 MCM4 T7 ochoa|psp DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
P35716 SOX11 S7 ochoa Transcription factor SOX-11 Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}.
P46019 PHKA2 S7 ochoa Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P46020 PHKA1 S7 ochoa Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P49450 CENPA S7 psp Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.
P49753 ACOT2 S7 ochoa Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128) Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:10944470, PubMed:16940157). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}.
P58005 SESN3 S7 ochoa Sestrin-3 (EC 1.11.1.-) May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000250|UniProtKB:Q9CYP7, ECO:0000269|PubMed:25263562}.
Q01105 SET S7 ochoa|psp Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}.
Q06330 RBPJ S7 ochoa Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). {ECO:0000250|UniProtKB:P31266, ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}.
Q13206 DDX10 S7 ochoa Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}.
Q13283 G3BP1 S7 ochoa Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}.
Q14161 GIT2 S7 ochoa ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}.
Q14493 SLBP S7 ochoa|psp Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}.
Q15544 TAF11 S7 ochoa Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473}.
Q15788 NCOA1 S7 ochoa Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
Q16537 PPP2R5E T7 ochoa Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q4V339 ZNG1F S7 ochoa Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). {ECO:0000250|UniProtKB:Q8VEH6, ECO:0000269|PubMed:35584702}.
Q52LA3 LIN52 S7 psp Protein lin-52 homolog None
Q5JSP0 FGD3 S7 ochoa FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q5JTY5 ZNG1C S7 ochoa Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q5JVS0 HABP4 S7 ochoa Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}.
Q5RIA9 ZNG1E S7 ochoa Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q5UIP0 RIF1 S7 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q6P3V2 ZNF585A S7 ochoa Zinc finger protein 585A May be involved in transcriptional regulation.
Q86U38 NOP9 S7 ochoa Nucleolar protein 9 None
Q86UA6 RPAIN S7 ochoa RPA-interacting protein (hRIP) Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. {ECO:0000269|PubMed:16135809}.
Q86VQ0 LCA5 S7 ochoa Lebercilin (Leber congenital amaurosis 5 protein) Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}.
Q8IZW8 TNS4 S7 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8N302 AGGF1 S7 ochoa Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}.
Q8NBL1 POGLUT1 S7 ochoa Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63) Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYB9, ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:21490058, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:27807076, ECO:0000269|PubMed:28775322}.
Q8NCH0 CHST14 T7 ochoa Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1) Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. {ECO:0000269|PubMed:19661164}.
Q8NFU5 IPMK S7 ochoa Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}.
Q8NFZ5 TNIP2 S7 ochoa TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.
Q8WTW3 COG1 S7 ochoa Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) Required for normal Golgi function. {ECO:0000250}.
Q8WUM0 NUP133 S7 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WVV9 HNRNPLL S7 ochoa Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}.
Q8WZA1 POMGNT1 S7 ochoa Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2) Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. {ECO:0000269|PubMed:11709191, ECO:0000269|PubMed:11742540, ECO:0000269|PubMed:26908613, ECO:0000269|PubMed:27391550, ECO:0000269|PubMed:27493216, ECO:0000269|PubMed:28512129}.
Q969L2 MAL2 S7 ochoa Protein MAL2 Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}.
Q96A54 ADIPOR1 S7 psp Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I) Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.
Q96DF8 ESS2 S7 ochoa Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}.
Q96EC8 YIPF6 S7 ochoa Protein YIPF6 (YIP1 family member 6) May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}.
Q96QK1 VPS35 S7 ochoa Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}.
Q96SF7 TBX15 S7 ochoa T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14) Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}.
Q9BQ89 FAM110A S7 ochoa Protein FAM110A None
Q9BQC3 DPH2 S7 ochoa 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}.
Q9BRT8 ZNG1A S7 ochoa Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q9BRZ2 TRIM56 S7 ochoa E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739). {ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160, ECO:0000269|PubMed:29426904, ECO:0000269|PubMed:31251739, ECO:0000269|PubMed:35952808}.
Q9H4A4 RNPEP S7 ochoa Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}.
Q9HBI1 PARVB S7 ochoa Beta-parvin (Affixin) Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
Q9NQC3 RTN4 S7 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NUP7 TRMT13 S7 ochoa tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). {ECO:0000250|UniProtKB:Q12383}.
Q9NZ45 CISD1 S7 ochoa CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET) L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:17584744, PubMed:21788481, PubMed:23758282). {ECO:0000250, ECO:0000250|UniProtKB:Q91WS0, ECO:0000269|PubMed:17584744, ECO:0000269|PubMed:17766440, ECO:0000269|PubMed:21788481, ECO:0000269|PubMed:23758282, ECO:0000269|PubMed:36194135}.
Q9UBY9 HSPB7 S7 ochoa Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) None
Q9UH92 MLX S7 ochoa Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Q9UL45 BLOC1S6 S7 ochoa Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}.
Q9ULD5 ZNF777 S7 ochoa Zinc finger protein 777 May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.
Q9UN86 G3BP2 S7 ochoa Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:35977029}.
Q9UPW6 SATB2 S7 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9Y534 CSDC2 S7 ochoa Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}.
Q9Y5S1 TRPV2 S7 ochoa Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}.
A1L429 GAGE12B; S7 Sugiyama G antigen 12B/C/D/E (GAGE-12B) (GAGE-12C) (GAGE-12D) (GAGE-12E) None
A6NDE8 GAGE12H S7 Sugiyama G antigen 12H (GAGE-12H) None
A6NER3 GAGE12J S7 Sugiyama G antigen 12J (GAGE-12J) None
O76087 GAGE7 S7 Sugiyama G antigen 7 (GAGE-7) (AL4) (Cancer/testis antigen 4.7) (CT4.7) (GAGE-12I) (GAGE-7B) (GAGE-8) None
P0CL80 GAGE12F S7 Sugiyama G antigen 12F (GAGE-12F) None
P0DSO3 GAGE4 S7 Sugiyama G antigen 4 (Cancer/testis antigen 4.4) (CT4.4) Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:7544395}.
Q13069 GAGE5 S7 Sugiyama G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5) None
Q13070 GAGE6 S7 Sugiyama G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6) None
Download
reactome_id name p -log10_p
R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 0.015712 1.804
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.031181 1.506
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 0.046409 1.333
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.056429 1.248
R-HSA-163765 ChREBP activates metabolic gene expression 0.071265 1.147
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.071265 1.147
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.071265 1.147
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.071265 1.147
R-HSA-5339716 Signaling by GSK3beta mutants 0.076158 1.118
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.081027 1.091
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.081027 1.091
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.081027 1.091
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.081027 1.091
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.081027 1.091
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.081027 1.091
R-HSA-196299 Beta-catenin phosphorylation cascade 0.095480 1.020
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.019220 1.716
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.025915 1.586
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.123716 0.908
R-HSA-350054 Notch-HLH transcription pathway 0.137506 0.862
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.013770 1.861
R-HSA-141424 Amplification of signal from the kinetochores 0.013770 1.861
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.173239 0.761
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.177601 0.751
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.177601 0.751
R-HSA-1855170 IPs transport between nucleus and cytosol 0.186258 0.730
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.186258 0.730
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.199075 0.701
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.215853 0.666
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.219994 0.658
R-HSA-167161 HIV Transcription Initiation 0.228209 0.642
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.228209 0.642
R-HSA-1989781 PPARA activates gene expression 0.232169 0.634
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.114403 0.942
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.082303 1.085
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.236058 0.627
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.173239 0.761
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.128337 0.892
R-HSA-68962 Activation of the pre-replicative complex 0.173239 0.761
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.090688 1.042
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.132934 0.876
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.244385 0.612
R-HSA-389513 Co-inhibition by CTLA4 0.123716 0.908
R-HSA-6803529 FGFR2 alternative splicing 0.137506 0.862
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.244385 0.612
R-HSA-774815 Nucleosome assembly 0.244385 0.612
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.081027 1.091
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.041645 1.380
R-HSA-73776 RNA Polymerase II Promoter Escape 0.236339 0.626
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.228209 0.642
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.260225 0.585
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.071265 1.147
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.155559 0.808
R-HSA-69618 Mitotic Spindle Checkpoint 0.021280 1.672
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.302114 0.520
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.302114 0.520
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.302114 0.520
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.302114 0.520
R-HSA-9012852 Signaling by NOTCH3 0.283372 0.548
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.109984 0.959
R-HSA-1538133 G0 and Early G1 0.181941 0.740
R-HSA-8875513 MET interacts with TNS proteins 0.026051 1.584
R-HSA-8932506 DAG1 core M1 glycosylations 0.051432 1.289
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.051432 1.289
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.056429 1.248
R-HSA-176974 Unwinding of DNA 0.061400 1.212
R-HSA-4839744 Signaling by APC mutants 0.071265 1.147
R-HSA-4839748 Signaling by AMER1 mutants 0.076158 1.118
R-HSA-4839735 Signaling by AXIN mutants 0.076158 1.118
R-HSA-4791275 Signaling by WNT in cancer 0.181941 0.740
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.207508 0.683
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.244385 0.612
R-HSA-9843745 Adipogenesis 0.182216 0.739
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.228209 0.642
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.219994 0.658
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.219994 0.658
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.210014 0.678
R-HSA-1980145 Signaling by NOTCH2 0.194825 0.710
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.041359 1.383
R-HSA-1855191 Synthesis of IPs in the nucleus 0.090688 1.042
R-HSA-156711 Polo-like kinase mediated events 0.114403 0.942
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.190553 0.720
R-HSA-6811438 Intra-Golgi traffic 0.228209 0.642
R-HSA-193697 p75NTR regulates axonogenesis 0.061400 1.212
R-HSA-8932504 DAG1 core M2 glycosylations 0.056429 1.248
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.076158 1.118
R-HSA-191859 snRNP Assembly 0.298405 0.525
R-HSA-194441 Metabolism of non-coding RNA 0.298405 0.525
R-HSA-9824272 Somitogenesis 0.244385 0.612
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.035017 1.456
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.256296 0.591
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.302114 0.520
R-HSA-446353 Cell-extracellular matrix interactions 0.095480 1.020
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.146580 0.834
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.061400 1.212
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.160014 0.796
R-HSA-180746 Nuclear import of Rev protein 0.194825 0.710
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.146580 0.834
R-HSA-8863678 Neurodegenerative Diseases 0.146580 0.834
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.067224 1.172
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.061400 1.212
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.061400 1.212
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.076158 1.118
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.076158 1.118
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.100248 0.999
R-HSA-3238698 WNT ligand biogenesis and trafficking 0.137506 0.862
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.160014 0.796
R-HSA-177243 Interactions of Rev with host cellular proteins 0.219994 0.658
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.219994 0.658
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.224112 0.650
R-HSA-68949 Orc1 removal from chromatin 0.271890 0.566
R-HSA-2467813 Separation of Sister Chromatids 0.072167 1.142
R-HSA-68882 Mitotic Anaphase 0.129325 0.888
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.130505 0.884
R-HSA-68877 Mitotic Prometaphase 0.102248 0.990
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.081027 1.091
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 0.104991 0.979
R-HSA-176187 Activation of ATR in response to replication stress 0.186258 0.730
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.214731 0.668
R-HSA-983189 Kinesins 0.302114 0.520
R-HSA-2022923 DS-GAG biosynthesis 0.076158 1.118
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.026558 1.576
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.211692 0.674
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.248376 0.605
R-HSA-163685 Integration of energy metabolism 0.193612 0.713
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.160014 0.796
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.011901 1.924
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.109889 0.959
R-HSA-68886 M Phase 0.062445 1.204
R-HSA-1483249 Inositol phosphate metabolism 0.139708 0.855
R-HSA-69206 G1/S Transition 0.169060 0.772
R-HSA-162599 Late Phase of HIV Life Cycle 0.207022 0.684
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 0.076158 1.118
R-HSA-209905 Catecholamine biosynthesis 0.109709 0.960
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.142055 0.848
R-HSA-5673000 RAF activation 0.194825 0.710
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.215853 0.666
R-HSA-2980766 Nuclear Envelope Breakdown 0.290928 0.536
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.034545 1.462
R-HSA-8878159 Transcriptional regulation by RUNX3 0.111682 0.952
R-HSA-3295583 TRP channels 0.155559 0.808
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.120271 0.920
R-HSA-193648 NRAGE signals death through JNK 0.287160 0.542
R-HSA-69278 Cell Cycle, Mitotic 0.035761 1.447
R-HSA-69190 DNA strand elongation 0.181941 0.740
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.100248 0.999
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.100248 0.999
R-HSA-1640170 Cell Cycle 0.090632 1.043
R-HSA-162587 HIV Life Cycle 0.236058 0.627
R-HSA-8931838 DAG1 glycosylations 0.181941 0.740
R-HSA-159418 Recycling of bile acids and salts 0.186258 0.730
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.146938 0.833
R-HSA-9033241 Peroxisomal protein import 0.298405 0.525
R-HSA-432142 Platelet sensitization by LDL 0.114403 0.942
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.173239 0.761
R-HSA-389356 Co-stimulation by CD28 0.256296 0.591
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.056429 1.248
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.215853 0.666
R-HSA-2299718 Condensation of Prophase Chromosomes 0.248376 0.605
R-HSA-69620 Cell Cycle Checkpoints 0.059997 1.222
R-HSA-9607240 FLT3 Signaling 0.224112 0.650
R-HSA-9939291 Matriglycan biosynthesis on DAG1 0.128337 0.892
R-HSA-69242 S Phase 0.218596 0.660
R-HSA-68875 Mitotic Prophase 0.157924 0.802
R-HSA-877300 Interferon gamma signaling 0.239951 0.620
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.141508 0.849
R-HSA-1181150 Signaling by NODAL 0.123716 0.908
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.160014 0.796
R-HSA-8875878 MET promotes cell motility 0.211692 0.674
R-HSA-193704 p75 NTR receptor-mediated signalling 0.115098 0.939
R-HSA-8982491 Glycogen metabolism 0.025915 1.586
R-HSA-199991 Membrane Trafficking 0.278546 0.555
R-HSA-400685 Sema4D in semaphorin signaling 0.151081 0.821
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.294676 0.531
R-HSA-69205 G1/S-Specific Transcription 0.203302 0.692
R-HSA-5689896 Ovarian tumor domain proteases 0.207508 0.683
R-HSA-3371556 Cellular response to heat stress 0.159770 0.797
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.053155 1.274
R-HSA-5675221 Negative regulation of MAPK pathway 0.228209 0.642
R-HSA-1483191 Synthesis of PC 0.252346 0.598
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.142055 0.848
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.194825 0.710
R-HSA-72306 tRNA processing 0.263364 0.579
R-HSA-209776 Metabolism of amine-derived hormones 0.287160 0.542
R-HSA-9705683 SARS-CoV-2-host interactions 0.143730 0.842
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.244385 0.612
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.164445 0.784
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.283372 0.548
R-HSA-186712 Regulation of beta-cell development 0.298405 0.525
R-HSA-73887 Death Receptor Signaling 0.230226 0.638
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.271890 0.566
R-HSA-8941326 RUNX2 regulates bone development 0.203302 0.692
R-HSA-3781865 Diseases of glycosylation 0.290700 0.537
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.181941 0.740
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.243518 0.613
R-HSA-75153 Apoptotic execution phase 0.248376 0.605
R-HSA-168325 Viral Messenger RNA Synthesis 0.305804 0.515
R-HSA-9793380 Formation of paraxial mesoderm 0.305804 0.515
R-HSA-73856 RNA Polymerase II Transcription Termination 0.305804 0.515
R-HSA-450294 MAP kinase activation 0.305804 0.515
R-HSA-211976 Endogenous sterols 0.305804 0.515
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.306279 0.514
R-HSA-9694516 SARS-CoV-2 Infection 0.309014 0.510
R-HSA-6784531 tRNA processing in the nucleus 0.309474 0.509
R-HSA-9707616 Heme signaling 0.309474 0.509
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.313125 0.504
R-HSA-373755 Semaphorin interactions 0.313125 0.504
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.313913 0.503
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.320371 0.494
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.323965 0.490
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.327541 0.485
R-HSA-167172 Transcription of the HIV genome 0.331098 0.480
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.338156 0.471
R-HSA-448424 Interleukin-17 signaling 0.338156 0.471
R-HSA-69202 Cyclin E associated events during G1/S transition 0.338156 0.471
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.338156 0.471
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.341657 0.466
R-HSA-5578749 Transcriptional regulation by small RNAs 0.345140 0.462
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.345140 0.462
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.345140 0.462
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.348605 0.458
R-HSA-69052 Switching of origins to a post-replicative state 0.348605 0.458
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.348605 0.458
R-HSA-9013694 Signaling by NOTCH4 0.352052 0.453
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.352052 0.453
R-HSA-1169408 ISG15 antiviral mechanism 0.355480 0.449
R-HSA-74160 Gene expression (Transcription) 0.357609 0.447
R-HSA-1980143 Signaling by NOTCH1 0.358891 0.445
R-HSA-913531 Interferon Signaling 0.359586 0.444
R-HSA-9679506 SARS-CoV Infections 0.361967 0.441
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.362284 0.441
R-HSA-416482 G alpha (12/13) signalling events 0.365659 0.437
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.369017 0.433
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.372357 0.429
R-HSA-5654738 Signaling by FGFR2 0.372357 0.429
R-HSA-6806834 Signaling by MET 0.372357 0.429
R-HSA-162906 HIV Infection 0.375349 0.426
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.375679 0.425
R-HSA-9707564 Cytoprotection by HMOX1 0.382272 0.418
R-HSA-6802957 Oncogenic MAPK signaling 0.388797 0.410
R-HSA-5687128 MAPK6/MAPK4 signaling 0.388797 0.410
R-HSA-8939211 ESR-mediated signaling 0.394086 0.404
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.395253 0.403
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.395253 0.403
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.395253 0.403
R-HSA-157118 Signaling by NOTCH 0.399659 0.398
R-HSA-9645723 Diseases of programmed cell death 0.401641 0.396
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.411099 0.386
R-HSA-73857 RNA Polymerase II Transcription 0.419793 0.377
R-HSA-68867 Assembly of the pre-replicative complex 0.420410 0.376
R-HSA-9837999 Mitochondrial protein degradation 0.423481 0.373
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.426536 0.370
R-HSA-6807878 COPI-mediated anterograde transport 0.432598 0.364
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.432598 0.364
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.438596 0.358
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.438596 0.358
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.438596 0.358
R-HSA-190236 Signaling by FGFR 0.438596 0.358
R-HSA-9614085 FOXO-mediated transcription 0.441572 0.355
R-HSA-3214847 HATs acetylate histones 0.441572 0.355
R-HSA-192105 Synthesis of bile acids and bile salts 0.441572 0.355
R-HSA-70171 Glycolysis 0.444532 0.352
R-HSA-5653656 Vesicle-mediated transport 0.446081 0.351
R-HSA-9020702 Interleukin-1 signaling 0.447477 0.349
R-HSA-9009391 Extra-nuclear estrogen signaling 0.447477 0.349
R-HSA-212436 Generic Transcription Pathway 0.451784 0.345
R-HSA-9833110 RSV-host interactions 0.459102 0.338
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.461970 0.335
R-HSA-418346 Platelet homeostasis 0.464823 0.333
R-HSA-9692914 SARS-CoV-1-host interactions 0.464823 0.333
R-HSA-69239 Synthesis of DNA 0.467662 0.330
R-HSA-211000 Gene Silencing by RNA 0.467662 0.330
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.470485 0.327
R-HSA-2672351 Stimuli-sensing channels 0.470485 0.327
R-HSA-69002 DNA Replication Pre-Initiation 0.473294 0.325
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.473294 0.325
R-HSA-8953854 Metabolism of RNA 0.474061 0.324
R-HSA-3700989 Transcriptional Regulation by TP53 0.475030 0.323
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.476088 0.322
R-HSA-166166 MyD88-independent TLR4 cascade 0.476088 0.322
R-HSA-194068 Bile acid and bile salt metabolism 0.476088 0.322
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.484382 0.315
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.492546 0.308
R-HSA-1257604 PIP3 activates AKT signaling 0.497157 0.304
R-HSA-70326 Glucose metabolism 0.500583 0.301
R-HSA-1592230 Mitochondrial biogenesis 0.500583 0.301
R-HSA-195721 Signaling by WNT 0.502190 0.299
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.503234 0.298
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.505871 0.296
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.505871 0.296
R-HSA-8878166 Transcriptional regulation by RUNX2 0.505871 0.296
R-HSA-73886 Chromosome Maintenance 0.511103 0.291
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.513699 0.289
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.513699 0.289
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.516281 0.287
R-HSA-2132295 MHC class II antigen presentation 0.516281 0.287
R-HSA-6809371 Formation of the cornified envelope 0.518849 0.285
R-HSA-162909 Host Interactions of HIV factors 0.518849 0.285
R-HSA-1280215 Cytokine Signaling in Immune system 0.522935 0.282
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.523946 0.281
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.523946 0.281
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.523946 0.281
R-HSA-114608 Platelet degranulation 0.528989 0.277
R-HSA-69481 G2/M Checkpoints 0.528989 0.277
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.536455 0.270
R-HSA-8856688 Golgi-to-ER retrograde transport 0.543804 0.265
R-HSA-9909396 Circadian clock 0.543804 0.265
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.546228 0.263
R-HSA-9018519 Estrogen-dependent gene expression 0.555797 0.255
R-HSA-5173105 O-linked glycosylation 0.558158 0.253
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.558158 0.253
R-HSA-9824446 Viral Infection Pathways 0.570127 0.244
R-HSA-9006925 Intracellular signaling by second messengers 0.572247 0.242
R-HSA-5683057 MAPK family signaling cascades 0.579750 0.237
R-HSA-199977 ER to Golgi Anterograde Transport 0.583325 0.234
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.585541 0.232
R-HSA-9758941 Gastrulation 0.587746 0.231
R-HSA-446652 Interleukin-1 family signaling 0.594291 0.226
R-HSA-69306 DNA Replication 0.596449 0.224
R-HSA-9609507 Protein localization 0.596449 0.224
R-HSA-5693532 DNA Double-Strand Break Repair 0.596449 0.224
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.598597 0.223
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.598597 0.223
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.600733 0.221
R-HSA-9006931 Signaling by Nuclear Receptors 0.603121 0.220
R-HSA-9610379 HCMV Late Events 0.604971 0.218
R-HSA-5633007 Regulation of TP53 Activity 0.611246 0.214
R-HSA-109581 Apoptosis 0.615374 0.211
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.625506 0.204
R-HSA-5619102 SLC transporter disorders 0.625506 0.204
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.643083 0.192
R-HSA-9678108 SARS-CoV-1 Infection 0.643083 0.192
R-HSA-168255 Influenza Infection 0.650631 0.187
R-HSA-201681 TCF dependent signaling in response to WNT 0.658021 0.182
R-HSA-69275 G2/M Transition 0.663462 0.178
R-HSA-453274 Mitotic G2-G2/M phases 0.667041 0.176
R-HSA-449147 Signaling by Interleukins 0.667715 0.175
R-HSA-983712 Ion channel transport 0.668817 0.175
R-HSA-168898 Toll-like Receptor Cascades 0.672341 0.172
R-HSA-1630316 Glycosaminoglycan metabolism 0.675827 0.170
R-HSA-72163 mRNA Splicing - Major Pathway 0.677556 0.169
R-HSA-9609690 HCMV Early Events 0.680988 0.167
R-HSA-5668914 Diseases of metabolism 0.688084 0.162
R-HSA-948021 Transport to the Golgi and subsequent modification 0.691067 0.160
R-HSA-1483206 Glycerophospholipid biosynthesis 0.692716 0.159
R-HSA-72172 mRNA Splicing 0.695988 0.157
R-HSA-5357801 Programmed Cell Death 0.697611 0.156
R-HSA-6805567 Keratinization 0.699226 0.155
R-HSA-3247509 Chromatin modifying enzymes 0.741130 0.130
R-HSA-5619115 Disorders of transmembrane transporters 0.758571 0.120
R-HSA-162582 Signal Transduction 0.759241 0.120
R-HSA-4839726 Chromatin organization 0.761149 0.119
R-HSA-9609646 HCMV Infection 0.762428 0.118
R-HSA-5688426 Deubiquitination 0.768721 0.114
R-HSA-388841 Regulation of T cell activation by CD28 family 0.769960 0.114
R-HSA-9711123 Cellular response to chemical stress 0.784323 0.106
R-HSA-76002 Platelet activation, signaling and aggregation 0.791168 0.102
R-HSA-211945 Phase I - Functionalization of compounds 0.795612 0.099
R-HSA-446728 Cell junction organization 0.795612 0.099
R-HSA-597592 Post-translational protein modification 0.795862 0.099
R-HSA-109582 Hemostasis 0.803571 0.095
R-HSA-2262752 Cellular responses to stress 0.805911 0.094
R-HSA-5673001 RAF/MAP kinase cascade 0.807357 0.093
R-HSA-1483257 Phospholipid metabolism 0.813479 0.090
R-HSA-5684996 MAPK1/MAPK3 signaling 0.814481 0.089
R-HSA-1500931 Cell-Cell communication 0.833431 0.079
R-HSA-1852241 Organelle biogenesis and maintenance 0.836985 0.077
R-HSA-212165 Epigenetic regulation of gene expression 0.839601 0.076
R-HSA-8957322 Metabolism of steroids 0.840464 0.075
R-HSA-1643685 Disease 0.844890 0.073
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.852479 0.069
R-HSA-73894 DNA Repair 0.868649 0.061
R-HSA-8953897 Cellular responses to stimuli 0.871696 0.060
R-HSA-8978868 Fatty acid metabolism 0.898711 0.046
R-HSA-5663205 Infectious disease 0.899673 0.046
R-HSA-446203 Asparagine N-linked glycosylation 0.906627 0.043
R-HSA-6798695 Neutrophil degranulation 0.922799 0.035
R-HSA-168256 Immune System 0.939619 0.027
R-HSA-211859 Biological oxidations 0.946128 0.024
R-HSA-422475 Axon guidance 0.952233 0.021
R-HSA-392499 Metabolism of proteins 0.954311 0.020
R-HSA-1266738 Developmental Biology 0.956432 0.019
R-HSA-9675108 Nervous system development 0.960995 0.017
R-HSA-556833 Metabolism of lipids 0.963353 0.016
R-HSA-71291 Metabolism of amino acids and derivatives 0.967990 0.014
R-HSA-168249 Innate Immune System 0.977346 0.010
R-HSA-1280218 Adaptive Immune System 0.979287 0.009
R-HSA-388396 GPCR downstream signalling 0.986480 0.006
R-HSA-1430728 Metabolism 0.987832 0.005
R-HSA-372790 Signaling by GPCR 0.991483 0.004
R-HSA-382551 Transport of small molecules 0.995750 0.002
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.829 0.728 1 0.856
CDK18CDK18 0.816 0.692 1 0.859
CDK19CDK19 0.816 0.680 1 0.869
P38GP38G 0.813 0.708 1 0.867
DYRK2DYRK2 0.812 0.694 1 0.820
CDK8CDK8 0.811 0.672 1 0.850
KISKIS 0.810 0.610 1 0.833
DYRK4DYRK4 0.809 0.685 1 0.862
CDK12CDK12 0.808 0.702 1 0.855
HIPK1HIPK1 0.808 0.679 1 0.817
JNK2JNK2 0.808 0.708 1 0.859
CLK3CLK3 0.808 0.506 1 0.645
SRPK1SRPK1 0.807 0.491 -3 0.846
CDK13CDK13 0.807 0.688 1 0.848
CDK17CDK17 0.807 0.679 1 0.852
HIPK4HIPK4 0.807 0.551 1 0.675
CDK7CDK7 0.805 0.667 1 0.841
CDK1CDK1 0.805 0.652 1 0.837
CDK3CDK3 0.803 0.593 1 0.855
ERK1ERK1 0.803 0.674 1 0.868
P38DP38D 0.803 0.684 1 0.870
JNK3JNK3 0.802 0.696 1 0.842
P38BP38B 0.802 0.677 1 0.853
MAKMAK 0.800 0.590 -2 0.791
DYRK1ADYRK1A 0.800 0.640 1 0.793
CDK5CDK5 0.800 0.646 1 0.829
DYRK1BDYRK1B 0.799 0.660 1 0.836
CDK16CDK16 0.798 0.647 1 0.851
P38AP38A 0.798 0.675 1 0.830
CDK9CDK9 0.797 0.663 1 0.852
HIPK3HIPK3 0.797 0.665 1 0.809
CDK14CDK14 0.797 0.676 1 0.842
CLK2CLK2 0.797 0.493 -3 0.843
CDK10CDK10 0.796 0.657 1 0.847
SRPK2SRPK2 0.795 0.428 -3 0.806
DYRK3DYRK3 0.791 0.570 1 0.790
JNK1JNK1 0.790 0.644 1 0.839
NLKNLK 0.789 0.617 1 0.693
ICKICK 0.789 0.492 -3 0.861
CLK1CLK1 0.788 0.496 -3 0.821
CLK4CLK4 0.788 0.462 -3 0.838
CDKL5CDKL5 0.787 0.349 -3 0.853
SRPK3SRPK3 0.785 0.395 -3 0.813
CDK4CDK4 0.784 0.668 1 0.856
ERK2ERK2 0.784 0.640 1 0.842
CDK6CDK6 0.781 0.636 1 0.857
CDKL1CDKL1 0.781 0.343 -3 0.847
ERK5ERK5 0.779 0.346 1 0.640
MOKMOK 0.777 0.533 1 0.747
COTCOT 0.776 0.028 2 0.841
MTORMTOR 0.776 0.242 1 0.502
CDK2CDK2 0.771 0.468 1 0.771
PRP4PRP4 0.769 0.413 -3 0.709
PIM3PIM3 0.768 0.129 -3 0.865
PRKD1PRKD1 0.767 0.143 -3 0.876
SKMLCKSKMLCK 0.767 0.127 -2 0.820
NDR2NDR2 0.766 0.096 -3 0.847
RSK3RSK3 0.765 0.171 -3 0.851
P90RSKP90RSK 0.765 0.187 -3 0.857
RSK2RSK2 0.764 0.171 -3 0.848
CAMK1BCAMK1B 0.763 0.156 -3 0.838
PIM1PIM1 0.763 0.176 -3 0.853
MOSMOS 0.762 0.025 1 0.395
PRKD2PRKD2 0.761 0.151 -3 0.853
PRPKPRPK 0.760 -0.007 -1 0.676
NDR1NDR1 0.760 0.079 -3 0.848
NUAK2NUAK2 0.760 0.145 -3 0.852
MARK4MARK4 0.759 0.083 4 0.767
WNK1WNK1 0.758 0.082 -2 0.853
PKN3PKN3 0.758 0.094 -3 0.839
MAPKAPK2MAPKAPK2 0.758 0.146 -3 0.845
CDC7CDC7 0.758 -0.043 1 0.332
PKACGPKACG 0.758 0.099 -2 0.687
CHAK2CHAK2 0.757 0.034 -1 0.683
PKCDPKCD 0.757 0.093 2 0.728
ATRATR 0.757 -0.004 1 0.388
MAPKAPK3MAPKAPK3 0.756 0.124 -3 0.854
PKACBPKACB 0.756 0.149 -2 0.626
MST4MST4 0.756 0.041 2 0.779
RAF1RAF1 0.756 -0.077 1 0.356
AURCAURC 0.755 0.106 -2 0.619
TBK1TBK1 0.755 -0.098 1 0.317
PAK1PAK1 0.755 0.091 -2 0.736
AKT2AKT2 0.754 0.202 -3 0.807
CAMLCKCAMLCK 0.753 0.108 -2 0.787
AMPKA1AMPKA1 0.753 0.079 -3 0.852
DAPK2DAPK2 0.753 0.125 -3 0.836
PKN2PKN2 0.753 0.064 -3 0.830
SGK3SGK3 0.753 0.168 -3 0.839
CAMK2DCAMK2D 0.753 0.069 -3 0.831
DCAMKL1DCAMKL1 0.752 0.167 -3 0.852
NIKNIK 0.752 0.078 -3 0.817
RSK4RSK4 0.752 0.152 -3 0.834
MSK2MSK2 0.752 0.139 -3 0.848
TSSK1TSSK1 0.752 0.095 -3 0.859
IKKBIKKB 0.752 -0.106 -2 0.635
CAMK2GCAMK2G 0.752 -0.016 2 0.828
QSKQSK 0.752 0.114 4 0.761
PRKD3PRKD3 0.751 0.157 -3 0.834
CAMK2ACAMK2A 0.751 0.114 2 0.806
LATS2LATS2 0.751 0.044 -5 0.554
PRKXPRKX 0.751 0.163 -3 0.799
PDHK4PDHK4 0.750 -0.118 1 0.422
ULK2ULK2 0.750 -0.120 2 0.750
PAK3PAK3 0.750 0.057 -2 0.727
PKCGPKCG 0.750 0.082 2 0.681
PKCBPKCB 0.750 0.082 2 0.657
IKKEIKKE 0.750 -0.125 1 0.306
NIM1NIM1 0.750 0.063 3 0.720
P70S6KBP70S6KB 0.749 0.109 -3 0.840
AMPKA2AMPKA2 0.749 0.092 -3 0.848
GCN2GCN2 0.749 -0.155 2 0.767
PDHK1PDHK1 0.748 -0.117 1 0.403
NEK6NEK6 0.748 -0.059 -2 0.776
PKCZPKCZ 0.748 0.070 2 0.716
BCKDKBCKDK 0.748 -0.065 -1 0.627
BMPR2BMPR2 0.748 -0.152 -2 0.785
IRE1IRE1 0.747 0.005 1 0.375
MSK1MSK1 0.747 0.129 -3 0.849
MNK2MNK2 0.746 0.061 -2 0.748
ERK7ERK7 0.746 0.215 2 0.495
SIKSIK 0.746 0.116 -3 0.824
LATS1LATS1 0.746 0.081 -3 0.843
PKCAPKCA 0.746 0.071 2 0.650
HUNKHUNK 0.745 -0.059 2 0.786
MNK1MNK1 0.745 0.075 -2 0.746
CAMK2BCAMK2B 0.745 0.062 2 0.796
DSTYKDSTYK 0.745 -0.145 2 0.806
TSSK2TSSK2 0.744 0.024 -5 0.657
PKG2PKG2 0.744 0.094 -2 0.633
RIPK3RIPK3 0.744 -0.084 3 0.688
MASTLMASTL 0.744 -0.085 -2 0.741
GRK1GRK1 0.744 -0.024 -2 0.667
IKKAIKKA 0.743 -0.085 -2 0.627
NUAK1NUAK1 0.743 0.089 -3 0.829
AKT1AKT1 0.743 0.164 -3 0.818
PKACAPKACA 0.743 0.140 -2 0.584
PIM2PIM2 0.742 0.158 -3 0.829
MARK3MARK3 0.742 0.073 4 0.720
PHKG1PHKG1 0.742 0.046 -3 0.846
WNK3WNK3 0.742 -0.099 1 0.378
QIKQIK 0.742 0.039 -3 0.810
NEK7NEK7 0.742 -0.157 -3 0.707
PINK1PINK1 0.742 0.144 1 0.541
MAPKAPK5MAPKAPK5 0.741 0.110 -3 0.818
MELKMELK 0.741 0.069 -3 0.838
GRK7GRK7 0.740 0.012 1 0.347
MLK2MLK2 0.740 -0.083 2 0.757
PAK2PAK2 0.740 0.029 -2 0.714
TGFBR2TGFBR2 0.740 -0.077 -2 0.679
MLK1MLK1 0.740 -0.130 2 0.734
BRSK1BRSK1 0.739 0.075 -3 0.845
VRK2VRK2 0.739 0.135 1 0.486
MARK2MARK2 0.739 0.058 4 0.694
MPSK1MPSK1 0.739 0.110 1 0.443
GRK5GRK5 0.739 -0.144 -3 0.721
AKT3AKT3 0.738 0.187 -3 0.791
DLKDLK 0.738 -0.117 1 0.382
PKCHPKCH 0.738 0.045 2 0.643
NEK9NEK9 0.738 -0.131 2 0.773
SGK1SGK1 0.738 0.208 -3 0.774
RIPK1RIPK1 0.737 -0.088 1 0.370
ATMATM 0.737 -0.065 1 0.322
SBKSBK 0.737 0.268 -3 0.742
DCAMKL2DCAMKL2 0.737 0.117 -3 0.840
AURBAURB 0.737 0.058 -2 0.611
GSK3AGSK3A 0.737 0.147 4 0.310
ULK1ULK1 0.736 -0.151 -3 0.682
MLK3MLK3 0.736 -0.053 2 0.673
WNK4WNK4 0.736 0.063 -2 0.868
PAK6PAK6 0.736 0.046 -2 0.655
PKCTPKCT 0.735 0.074 2 0.655
BMPR1BBMPR1B 0.735 -0.042 1 0.316
ANKRD3ANKRD3 0.735 -0.123 1 0.396
MYLK4MYLK4 0.735 0.076 -2 0.705
PKRPKR 0.735 -0.020 1 0.396
DNAPKDNAPK 0.735 -0.027 1 0.309
GRK6GRK6 0.735 -0.107 1 0.345
TTBK2TTBK2 0.735 -0.099 2 0.749
IRE2IRE2 0.734 -0.038 2 0.693
TLK2TLK2 0.734 -0.061 1 0.336
CAMK1GCAMK1G 0.734 0.105 -3 0.815
AURAAURA 0.734 0.035 -2 0.578
BRSK2BRSK2 0.734 0.019 -3 0.829
CAMK4CAMK4 0.734 -0.020 -3 0.821
SMG1SMG1 0.733 -0.057 1 0.361
NEK2NEK2 0.733 -0.068 2 0.750
PASKPASK 0.733 0.084 -3 0.851
CHK1CHK1 0.732 0.009 -3 0.838
ALK4ALK4 0.732 -0.057 -2 0.729
CHAK1CHAK1 0.732 -0.072 2 0.732
FAM20CFAM20C 0.732 -0.025 2 0.560
MEK1MEK1 0.731 -0.094 2 0.806
PKCIPKCI 0.731 0.069 2 0.681
TGFBR1TGFBR1 0.731 -0.056 -2 0.695
PKCEPKCE 0.730 0.106 2 0.652
TAO3TAO3 0.730 0.018 1 0.378
PLK4PLK4 0.730 -0.071 2 0.637
MST3MST3 0.729 0.004 2 0.757
MARK1MARK1 0.729 0.023 4 0.730
SSTKSSTK 0.729 0.048 4 0.752
PAK5PAK5 0.729 0.047 -2 0.592
CK1ECK1E 0.728 -0.011 -3 0.459
BRAFBRAF 0.728 -0.022 -4 0.889
MLK4MLK4 0.728 -0.092 2 0.659
CAMK1DCAMK1D 0.727 0.125 -3 0.796
PAK4PAK4 0.727 0.056 -2 0.598
NEK5NEK5 0.727 -0.061 1 0.391
DAPK3DAPK3 0.726 0.107 -3 0.846
MEKK1MEKK1 0.726 -0.092 1 0.391
PLK1PLK1 0.726 -0.129 -2 0.674
MEKK2MEKK2 0.726 -0.060 2 0.751
LKB1LKB1 0.725 0.029 -3 0.737
PKN1PKN1 0.725 0.109 -3 0.813
YSK4YSK4 0.725 -0.161 1 0.329
P70S6KP70S6K 0.725 0.093 -3 0.805
MEK5MEK5 0.724 -0.090 2 0.769
PDK1PDK1 0.724 0.066 1 0.375
GRK4GRK4 0.724 -0.187 -2 0.707
SMMLCKSMMLCK 0.724 0.080 -3 0.828
PBKPBK 0.724 0.073 1 0.429
DRAK1DRAK1 0.724 -0.079 1 0.273
SNRKSNRK 0.723 -0.059 2 0.647
CK1G1CK1G1 0.723 -0.021 -3 0.437
IRAK4IRAK4 0.722 -0.056 1 0.381
ZAKZAK 0.722 -0.116 1 0.356
PHKG2PHKG2 0.722 0.020 -3 0.810
HASPINHASPIN 0.721 0.160 -1 0.703
ROCK2ROCK2 0.721 0.118 -3 0.843
MEKK6MEKK6 0.721 0.014 1 0.403
PLK3PLK3 0.721 -0.097 2 0.790
MRCKBMRCKB 0.720 0.122 -3 0.811
CK1DCK1D 0.720 -0.005 -3 0.407
ACVR2AACVR2A 0.720 -0.112 -2 0.662
ALK2ALK2 0.720 -0.095 -2 0.698
ACVR2BACVR2B 0.720 -0.117 -2 0.672
DAPK1DAPK1 0.720 0.104 -3 0.838
CHK2CHK2 0.720 0.149 -3 0.778
MAP3K15MAP3K15 0.719 -0.001 1 0.362
TNIKTNIK 0.719 0.033 3 0.820
GCKGCK 0.719 -0.013 1 0.359
KHS1KHS1 0.718 0.051 1 0.352
MEKK3MEKK3 0.718 -0.147 1 0.375
GSK3BGSK3B 0.718 0.015 4 0.306
CK1A2CK1A2 0.718 -0.013 -3 0.416
HGKHGK 0.717 0.004 3 0.809
BUB1BUB1 0.717 0.070 -5 0.572
GAKGAK 0.717 0.003 1 0.449
TAO2TAO2 0.717 -0.017 2 0.777
GRK2GRK2 0.716 -0.101 -2 0.605
STK33STK33 0.716 0.006 2 0.688
TLK1TLK1 0.716 -0.130 -2 0.708
CAMK1ACAMK1A 0.715 0.126 -3 0.784
KHS2KHS2 0.715 0.063 1 0.359
HPK1HPK1 0.715 0.001 1 0.344
LRRK2LRRK2 0.714 0.061 2 0.790
DMPK1DMPK1 0.714 0.145 -3 0.815
PERKPERK 0.713 -0.165 -2 0.719
BMPR1ABMPR1A 0.713 -0.079 1 0.295
MINKMINK 0.713 -0.041 1 0.354
NEK8NEK8 0.713 -0.104 2 0.751
NEK11NEK11 0.713 -0.110 1 0.359
CAMKK2CAMKK2 0.713 -0.091 -2 0.665
PKG1PKG1 0.712 0.088 -2 0.564
HRIHRI 0.712 -0.178 -2 0.743
MRCKAMRCKA 0.711 0.079 -3 0.815
NEK4NEK4 0.711 -0.101 1 0.368
CRIKCRIK 0.709 0.139 -3 0.822
LOKLOK 0.709 -0.039 -2 0.691
CAMKK1CAMKK1 0.709 -0.155 -2 0.655
NEK1NEK1 0.708 -0.078 1 0.377
CK2A2CK2A2 0.708 -0.044 1 0.238
ROCK1ROCK1 0.707 0.104 -3 0.823
TTBK1TTBK1 0.706 -0.106 2 0.705
EEF2KEEF2K 0.706 -0.038 3 0.808
YSK1YSK1 0.706 -0.040 2 0.735
GRK3GRK3 0.705 -0.096 -2 0.560
SLKSLK 0.704 -0.065 -2 0.626
MST2MST2 0.704 -0.154 1 0.356
YANK3YANK3 0.703 0.050 2 0.542
VRK1VRK1 0.702 -0.074 2 0.792
IRAK1IRAK1 0.702 -0.193 -1 0.566
NEK3NEK3 0.702 -0.047 1 0.395
OSR1OSR1 0.700 -0.045 2 0.757
PLK2PLK2 0.700 -0.049 -3 0.664
CK2A1CK2A1 0.697 -0.056 1 0.222
TAK1TAK1 0.697 -0.175 1 0.348
MYO3BMYO3B 0.696 -0.009 2 0.755
MST1MST1 0.695 -0.163 1 0.344
MEK2MEK2 0.694 -0.165 2 0.767
TAO1TAO1 0.694 -0.033 1 0.338
ASK1ASK1 0.693 -0.058 1 0.347
RIPK2RIPK2 0.689 -0.189 1 0.313
BIKEBIKE 0.689 -0.009 1 0.422
CK1ACK1A 0.688 -0.024 -3 0.324
MYO3AMYO3A 0.687 -0.066 1 0.358
TTKTTK 0.687 -0.097 -2 0.697
AAK1AAK1 0.686 0.035 1 0.407
PDHK3_TYRPDHK3_TYR 0.684 0.152 4 0.794
LIMK2_TYRLIMK2_TYR 0.683 0.190 -3 0.798
PKMYT1_TYRPKMYT1_TYR 0.681 0.197 3 0.792
MAP2K4_TYRMAP2K4_TYR 0.678 0.073 -1 0.698
TESK1_TYRTESK1_TYR 0.677 0.080 3 0.820
PDHK4_TYRPDHK4_TYR 0.676 0.055 2 0.830
MAP2K6_TYRMAP2K6_TYR 0.675 0.042 -1 0.711
ALPHAK3ALPHAK3 0.674 -0.128 -1 0.580
BMPR2_TYRBMPR2_TYR 0.672 0.026 -1 0.711
STLK3STLK3 0.672 -0.167 1 0.330
MAP2K7_TYRMAP2K7_TYR 0.672 -0.014 2 0.812
PDHK1_TYRPDHK1_TYR 0.672 -0.004 -1 0.699
CK1G3CK1G3 0.671 -0.014 -3 0.280
LIMK1_TYRLIMK1_TYR 0.669 0.046 2 0.800
YANK2YANK2 0.669 0.009 2 0.551
PINK1_TYRPINK1_TYR 0.668 -0.045 1 0.415
RETRET 0.663 -0.108 1 0.398
MST1RMST1R 0.663 -0.069 3 0.756
TNNI3K_TYRTNNI3K_TYR 0.663 0.018 1 0.463
EPHA6EPHA6 0.663 -0.045 -1 0.653
DDR1DDR1 0.662 -0.060 4 0.736
TNK1TNK1 0.661 0.035 3 0.714
TNK2TNK2 0.661 -0.015 3 0.703
EPHB4EPHB4 0.660 -0.075 -1 0.617
CSF1RCSF1R 0.660 -0.081 3 0.728
ROS1ROS1 0.660 -0.097 3 0.690
JAK2JAK2 0.659 -0.120 1 0.417
FGRFGR 0.657 -0.127 1 0.419
TYRO3TYRO3 0.657 -0.129 3 0.723
JAK3JAK3 0.656 -0.108 1 0.373
METMET 0.656 -0.055 3 0.726
DDR2DDR2 0.656 0.023 3 0.663
TYK2TYK2 0.656 -0.197 1 0.390
ABL2ABL2 0.655 -0.097 -1 0.584
BLKBLK 0.655 -0.049 -1 0.627
LCKLCK 0.655 -0.066 -1 0.614
FGFR2FGFR2 0.654 -0.060 3 0.731
KDRKDR 0.654 -0.066 3 0.700
YES1YES1 0.654 -0.111 -1 0.622
NEK10_TYRNEK10_TYR 0.653 -0.080 1 0.309
TXKTXK 0.652 -0.088 1 0.377
ABL1ABL1 0.652 -0.109 -1 0.566
FGFR1FGFR1 0.652 -0.059 3 0.695
EPHA4EPHA4 0.651 -0.056 2 0.789
HCKHCK 0.651 -0.125 -1 0.608
CK1G2CK1G2 0.651 -0.024 -3 0.362
ITKITK 0.650 -0.106 -1 0.572
PDGFRBPDGFRB 0.650 -0.151 3 0.733
JAK1JAK1 0.649 -0.097 1 0.361
INSRRINSRR 0.648 -0.146 3 0.678
KITKIT 0.648 -0.132 3 0.733
FERFER 0.647 -0.204 1 0.400
FGFR3FGFR3 0.645 -0.075 3 0.710
EPHB3EPHB3 0.645 -0.138 -1 0.595
FYNFYN 0.644 -0.076 -1 0.607
EPHB1EPHB1 0.644 -0.163 1 0.362
TEKTEK 0.644 -0.083 3 0.665
FLT1FLT1 0.644 -0.119 -1 0.631
SRMSSRMS 0.644 -0.178 1 0.364
MERTKMERTK 0.644 -0.133 3 0.721
EPHB2EPHB2 0.643 -0.139 -1 0.587
BMXBMX 0.643 -0.105 -1 0.513
FLT3FLT3 0.642 -0.184 3 0.738
EPHA7EPHA7 0.642 -0.088 2 0.787
PTK2PTK2 0.641 -0.003 -1 0.625
EPHA1EPHA1 0.641 -0.111 3 0.717
AXLAXL 0.641 -0.156 3 0.705
INSRINSR 0.640 -0.143 3 0.669
PDGFRAPDGFRA 0.639 -0.194 3 0.726
ERBB2ERBB2 0.639 -0.150 1 0.344
EPHA3EPHA3 0.638 -0.104 2 0.765
WEE1_TYRWEE1_TYR 0.638 -0.093 -1 0.539
PTK2BPTK2B 0.638 -0.082 -1 0.525
NTRK3NTRK3 0.638 -0.146 -1 0.570
EGFREGFR 0.637 -0.093 1 0.306
NTRK1NTRK1 0.637 -0.202 -1 0.604
PTK6PTK6 0.637 -0.184 -1 0.488
FRKFRK 0.637 -0.141 -1 0.615
FLT4FLT4 0.636 -0.149 3 0.696
SRCSRC 0.636 -0.116 -1 0.586
LTKLTK 0.636 -0.163 3 0.673
FGFR4FGFR4 0.635 -0.086 -1 0.544
EPHA8EPHA8 0.635 -0.089 -1 0.598
MATKMATK 0.635 -0.111 -1 0.522
ALKALK 0.634 -0.180 3 0.641
NTRK2NTRK2 0.634 -0.212 3 0.689
TECTEC 0.633 -0.176 -1 0.488
LYNLYN 0.633 -0.151 3 0.667
CSKCSK 0.633 -0.104 2 0.799
BTKBTK 0.632 -0.234 -1 0.526
ERBB4ERBB4 0.630 -0.071 1 0.300
SYKSYK 0.628 -0.088 -1 0.605
EPHA5EPHA5 0.628 -0.144 2 0.759
EPHA2EPHA2 0.627 -0.099 -1 0.568
IGF1RIGF1R 0.622 -0.149 3 0.611
ZAP70ZAP70 0.622 -0.060 -1 0.553
MUSKMUSK 0.620 -0.155 1 0.280
FESFES 0.602 -0.181 -1 0.468