Motif 1207 (n=42)

Position-wise Probabilities
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uniprot genes site source protein function
B2RUZ4 SMIM1 S6 ochoa Small integral membrane protein 1 (Vel blood group antigen) Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}.
O00161 SNAP23 S6 ochoa|psp Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
O43242 PSMD3 S6 psp 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.
O43791 SPOP S6 ochoa|psp Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}.
O76021 RSL1D1 S6 ochoa Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.
O94806 PRKD3 S6 ochoa Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
P04632 CAPNS1 S6 ochoa Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:O88456}.
P09651 HNRNPA1 S6 ochoa|psp Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}.
P17844 DDX5 S6 ochoa Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.
P19174 PLCG1 S6 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}.
P33991 MCM4 S6 ochoa DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
Q07869 PPARA S6 psp Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
Q13522 PPP1R1A S6 ochoa Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Q14451 GRB7 S6 ochoa Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.
Q15742 NAB2 S6 ochoa NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q15911 ZFHX3 S6 ochoa Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.
Q5BKX5 ACTMAP S6 ochoa Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}.
Q5I0X4 PEX39 S6 ochoa Peroxisomal biogenesis factor 39 May be a peroxin involved in the PTS2-mediated protein import pathway. {ECO:0000305|PubMed:37160800}.
Q6NSJ2 PHLDB3 S6 ochoa Pleckstrin homology-like domain family B member 3 None
Q6PCB5 RSBN1L S6 ochoa Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}.
Q7KZI7 MARK2 T6 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q86UP3 ZFHX4 S6 ochoa Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}.
Q86VM9 ZC3H18 S6 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q8N568 DCLK2 S6 ochoa Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
Q8WYQ5 DGCR8 S6 ochoa Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.
Q96AE4 FUBP1 T6 ochoa Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}.
Q96DG6 CMBL Y6 ochoa Carboxymethylenebutenolidase homolog (EC 3.1.-.-) Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}.
Q96ER3 SAAL1 S6 ochoa Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1) Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli. {ECO:0000269|PubMed:22127701}.
Q96NT5 SLC46A1 S6 ochoa Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:19762432, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:31792273, PubMed:32893190, PubMed:34619546). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:32893190). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:32893190, PubMed:34040256). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases (PubMed:18524888, PubMed:19762432, PubMed:22345511, PubMed:25608532, PubMed:28802835, PubMed:29326243, PubMed:34040256, PubMed:34619546). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (PubMed:19074442). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:17156779). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:32621820). Hence, participates in the trafficking of heme and increases intracellular iron content (PubMed:32621820). {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:17475902, ECO:0000269|PubMed:18524888, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:19389703, ECO:0000269|PubMed:19762432, ECO:0000269|PubMed:22345511, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:25608532, ECO:0000269|PubMed:28802835, ECO:0000269|PubMed:29326243, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:31494288, ECO:0000269|PubMed:31792273, ECO:0000269|PubMed:32621820, ECO:0000269|PubMed:32893190, ECO:0000269|PubMed:34040256, ECO:0000269|PubMed:34619546}.; FUNCTION: [Isoform 2]: Inactive isoform which is not able to mediate proton-coupled folate transport. {ECO:0000269|PubMed:17129779}.
Q9BQI3 EIF2AK1 S6 ochoa Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}.
Q9BSA9 TMEM175 T6 ochoa Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175) Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35333573, PubMed:35750034, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (PubMed:35750034). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:32267231). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32228865, PubMed:32267231, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021). {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:28723891, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32267231, ECO:0000269|PubMed:33505021, ECO:0000269|PubMed:35333573, ECO:0000269|PubMed:35750034, ECO:0000269|PubMed:37390818}.
Q9BXP2 SLC12A9 S6 ochoa Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (PubMed:10871601). May play a role in lysosomal ion flux and osmoregulation (PubMed:38334070). {ECO:0000269|PubMed:10871601, ECO:0000269|PubMed:38334070}.
Q9H6S0 YTHDC2 S6 ochoa 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}.
Q9H9E3 COG4 S6 ochoa Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}.
Q9NUE0 ZDHHC18 Y6 ochoa Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}.
Q9NUU6 OTULINL S6 ochoa Inactive ubiquitin thioesterase OTULINL Lacks deubiquitinase activity. {ECO:0000269|PubMed:31056421}.
Q9NYF5 FAM13B S6 ochoa Protein FAM13B (GAP-like protein N61) None
Q9P0U4 CXXC1 S6 ochoa CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.
Q9ULD5 ZNF777 S6 ochoa Zinc finger protein 777 May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.
Q9Y3Z3 SAMHD1 S6 ochoa Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}.
A0A2R8Y4L2 HNRNPA1L3 S6 Sugiyama Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) None
P28066 PSMA5 S6 Sugiyama Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
Download
reactome_id name p -log10_p
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.000389 3.410
R-HSA-9907900 Proteasome assembly 0.010237 1.990
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.005328 2.273
R-HSA-68949 Orc1 removal from chromatin 0.000742 3.130
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.010998 1.959
R-HSA-69002 DNA Replication Pre-Initiation 0.005376 2.270
R-HSA-9930044 Nuclear RNA decay 0.005898 2.229
R-HSA-69052 Switching of origins to a post-replicative state 0.001749 2.757
R-HSA-1236974 ER-Phagosome pathway 0.002993 2.524
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.008440 2.074
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.008440 2.074
R-HSA-68867 Assembly of the pre-replicative complex 0.003439 2.464
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.005610 2.251
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.006802 2.167
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.006802 2.167
R-HSA-9932298 Degradation of CRY and PER proteins 0.009140 2.039
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.009140 2.039
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.011389 1.944
R-HSA-4641258 Degradation of DVL 0.007438 2.129
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.008100 2.092
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.002662 2.575
R-HSA-9031628 NGF-stimulated transcription 0.011785 1.929
R-HSA-186763 Downstream signal transduction 0.005328 2.273
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.007117 2.148
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.007117 2.148
R-HSA-4641257 Degradation of AXIN 0.007438 2.129
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.007438 2.129
R-HSA-1236975 Antigen processing-Cross presentation 0.005254 2.279
R-HSA-69239 Synthesis of DNA 0.005134 2.290
R-HSA-180534 Vpu mediated degradation of CD4 0.006193 2.208
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.006494 2.187
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.006494 2.187
R-HSA-169911 Regulation of Apoptosis 0.006802 2.167
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.009140 2.039
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.009140 2.039
R-HSA-5658442 Regulation of RAS by GAPs 0.012595 1.900
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.008440 2.074
R-HSA-5362768 Hh mutants are degraded by ERAD 0.008787 2.056
R-HSA-202403 TCR signaling 0.005499 2.260
R-HSA-69206 G1/S Transition 0.008013 2.096
R-HSA-69242 S Phase 0.012674 1.897
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.008100 2.092
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.009865 2.006
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.010237 1.990
R-HSA-4608870 Asymmetric localization of PCP proteins 0.010614 1.974
R-HSA-8863678 Neurodegenerative Diseases 0.003549 2.450
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.003549 2.450
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.008487 2.071
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.004270 2.370
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.010614 1.974
R-HSA-69481 G2/M Checkpoints 0.008327 2.079
R-HSA-166520 Signaling by NTRKs 0.012674 1.897
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.006494 2.187
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.008440 2.074
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.008787 2.056
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.010614 1.974
R-HSA-5358351 Signaling by Hedgehog 0.010549 1.977
R-HSA-5632684 Hedgehog 'on' state 0.001629 2.788
R-HSA-9766229 Degradation of CDH1 0.012187 1.914
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.010614 1.974
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.010614 1.974
R-HSA-9909396 Circadian clock 0.000929 3.032
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.012271 1.911
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.006802 2.167
R-HSA-8853659 RET signaling 0.007117 2.148
R-HSA-69541 Stabilization of p53 0.008100 2.092
R-HSA-8878159 Transcriptional regulation by RUNX3 0.003925 2.406
R-HSA-9824272 Somitogenesis 0.010614 1.974
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.012187 1.914
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.012187 1.914
R-HSA-8953897 Cellular responses to stimuli 0.005990 2.223
R-HSA-9034793 Activated NTRK3 signals through PLCG1 0.014490 1.839
R-HSA-167021 PLC-gamma1 signalling 0.014490 1.839
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.013429 1.872
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.013855 1.858
R-HSA-69306 DNA Replication 0.013715 1.863
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.014286 1.845
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.013429 1.872
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.013855 1.858
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.014724 1.832
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.015167 1.819
R-HSA-1169091 Activation of NF-kappaB in B cells 0.013009 1.886
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.013009 1.886
R-HSA-8948751 Regulation of PTEN stability and activity 0.013855 1.858
R-HSA-5358346 Hedgehog ligand biogenesis 0.013009 1.886
R-HSA-1227986 Signaling by ERBB2 0.016997 1.770
R-HSA-9764561 Regulation of CDH1 Function 0.015616 1.806
R-HSA-351202 Metabolism of polyamines 0.016997 1.770
R-HSA-9026527 Activated NTRK2 signals through PLCG1 0.017363 1.760
R-HSA-1251932 PLCG1 events in ERBB2 signaling 0.017363 1.760
R-HSA-1306955 GRB7 events in ERBB2 signaling 0.017363 1.760
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.017468 1.758
R-HSA-9793380 Formation of paraxial mesoderm 0.017468 1.758
R-HSA-186797 Signaling by PDGF 0.017945 1.746
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.017945 1.746
R-HSA-9707616 Heme signaling 0.017945 1.746
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.017945 1.746
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.018357 1.736
R-HSA-69615 G1/S DNA Damage Checkpoints 0.018428 1.735
R-HSA-1234174 Cellular response to hypoxia 0.019409 1.712
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.023085 1.637
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.023012 1.638
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.027085 1.567
R-HSA-5689603 UCH proteinases 0.025185 1.599
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.022482 1.648
R-HSA-453276 Regulation of mitotic cell cycle 0.022482 1.648
R-HSA-5654738 Signaling by FGFR2 0.027439 1.562
R-HSA-389948 Co-inhibition by PD-1 0.026159 1.582
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.027439 1.562
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.029181 1.535
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.021956 1.658
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.029772 1.526
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.023012 1.638
R-HSA-69202 Cyclin E associated events during G1/S transition 0.021956 1.658
R-HSA-9013694 Signaling by NOTCH4 0.024089 1.618
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.021956 1.658
R-HSA-5619084 ABC transporter disorders 0.026302 1.580
R-HSA-4086400 PCP/CE pathway 0.026302 1.580
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.023012 1.638
R-HSA-2262752 Cellular responses to stress 0.030128 1.521
R-HSA-5687128 MAPK6/MAPK4 signaling 0.030367 1.518
R-HSA-9675108 Nervous system development 0.030666 1.513
R-HSA-381038 XBP1(S) activates chaperone genes 0.031571 1.501
R-HSA-212718 EGFR interacts with phospholipase C-gamma 0.031607 1.500
R-HSA-9645723 Diseases of programmed cell death 0.032794 1.484
R-HSA-202424 Downstream TCR signaling 0.034036 1.468
R-HSA-176974 Unwinding of DNA 0.034431 1.463
R-HSA-9840373 Cellular response to mitochondrial stress 0.034431 1.463
R-HSA-381070 IRE1alpha activates chaperones 0.035296 1.452
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.036870 1.433
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.037247 1.429
R-HSA-8953854 Metabolism of RNA 0.037402 1.427
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.038524 1.414
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.039182 1.407
R-HSA-210990 PECAM1 interactions 0.040055 1.397
R-HSA-190236 Signaling by FGFR 0.040513 1.392
R-HSA-5610787 Hedgehog 'off' state 0.041860 1.378
R-HSA-382556 ABC-family proteins mediated transport 0.041860 1.378
R-HSA-9020702 Interleukin-1 signaling 0.042540 1.371
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.051208 1.291
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.053977 1.268
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 0.059490 1.226
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.062235 1.206
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.070422 1.152
R-HSA-6803529 FGFR2 alternative splicing 0.078539 1.105
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.045648 1.341
R-HSA-9843745 Adipogenesis 0.068769 1.163
R-HSA-5655291 Signaling by FGFR4 in disease 0.051208 1.291
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.062235 1.206
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.062235 1.206
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.075841 1.120
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.083912 1.076
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.081230 1.090
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.064972 1.187
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.073135 1.136
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.073135 1.136
R-HSA-9948299 Ribosome-associated quality control 0.075360 1.123
R-HSA-909733 Interferon alpha/beta signaling 0.054716 1.262
R-HSA-69620 Cell Cycle Checkpoints 0.047555 1.323
R-HSA-388841 Regulation of T cell activation by CD28 family 0.046722 1.330
R-HSA-210993 Tie2 Signaling 0.064972 1.187
R-HSA-9860931 Response of endothelial cells to shear stress 0.044605 1.351
R-HSA-2871837 FCERI mediated NF-kB activation 0.081287 1.090
R-HSA-9855142 Cellular responses to mechanical stimuli 0.052486 1.280
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.048432 1.315
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.062235 1.206
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.051208 1.291
R-HSA-8878166 Transcriptional regulation by RUNX2 0.057741 1.239
R-HSA-162909 Host Interactions of HIV factors 0.061602 1.210
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.067701 1.169
R-HSA-9711123 Cellular response to chemical stress 0.051831 1.285
R-HSA-3858494 Beta-catenin independent WNT signaling 0.073694 1.133
R-HSA-1474228 Degradation of the extracellular matrix 0.069582 1.158
R-HSA-6807070 PTEN Regulation 0.076198 1.118
R-HSA-422475 Axon guidance 0.082635 1.083
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.059275 1.227
R-HSA-381119 Unfolded Protein Response (UPR) 0.076198 1.118
R-HSA-9758941 Gastrulation 0.085607 1.067
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.086587 1.063
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.086587 1.063
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.087355 1.059
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.088233 1.054
R-HSA-446652 Interleukin-1 family signaling 0.088233 1.054
R-HSA-9006925 Intracellular signaling by second messengers 0.088894 1.051
R-HSA-1643713 Signaling by EGFR in Cancer 0.089254 1.049
R-HSA-1989781 PPARA activates gene expression 0.090882 1.042
R-HSA-5655332 Signaling by FGFR3 in disease 0.091914 1.037
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.091914 1.037
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.092662 1.033
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.093555 1.029
R-HSA-109581 Apoptosis 0.097155 1.013
R-HSA-5654708 Downstream signaling of activated FGFR3 0.097211 1.012
R-HSA-9006335 Signaling by Erythropoietin 0.097211 1.012
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.097211 1.012
R-HSA-2467813 Separation of Sister Chromatids 0.098970 1.004
R-HSA-68962 Activation of the pre-replicative complex 0.099848 1.001
R-HSA-2424491 DAP12 signaling 0.099848 1.001
R-HSA-5654716 Downstream signaling of activated FGFR4 0.099848 1.001
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.099848 1.001
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.099848 1.001
R-HSA-69190 DNA strand elongation 0.105099 0.978
R-HSA-5621481 C-type lectin receptors (CLRs) 0.106325 0.973
R-HSA-176187 Activation of ATR in response to replication stress 0.107713 0.968
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.107713 0.968
R-HSA-5689880 Ub-specific processing proteases 0.108187 0.966
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.108187 0.966
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.108187 0.966
R-HSA-9678108 SARS-CoV-1 Infection 0.110057 0.958
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.110320 0.957
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.112920 0.947
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.113767 0.944
R-HSA-913531 Interferon Signaling 0.113767 0.944
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.115512 0.937
R-HSA-5654696 Downstream signaling of activated FGFR2 0.115512 0.937
R-HSA-5654687 Downstream signaling of activated FGFR1 0.115512 0.937
R-HSA-201681 TCF dependent signaling in response to WNT 0.117625 0.929
R-HSA-69275 G2/M Transition 0.120497 0.919
R-HSA-196757 Metabolism of folate and pterines 0.120674 0.918
R-HSA-453274 Mitotic G2-G2/M phases 0.122422 0.912
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.125806 0.900
R-HSA-201556 Signaling by ALK 0.125806 0.900
R-HSA-72163 mRNA Splicing - Major Pathway 0.128241 0.892
R-HSA-202433 Generation of second messenger molecules 0.128361 0.892
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.130195 0.885
R-HSA-6811438 Intra-Golgi traffic 0.133449 0.875
R-HSA-5655302 Signaling by FGFR1 in disease 0.133449 0.875
R-HSA-376176 Signaling by ROBO receptors 0.137091 0.863
R-HSA-5654743 Signaling by FGFR4 0.138509 0.859
R-HSA-1433557 Signaling by SCF-KIT 0.138509 0.859
R-HSA-72172 mRNA Splicing 0.139076 0.857
R-HSA-5357801 Programmed Cell Death 0.140071 0.854
R-HSA-2172127 DAP12 interactions 0.141028 0.851
R-HSA-373752 Netrin-1 signaling 0.141028 0.851
R-HSA-5654741 Signaling by FGFR3 0.143539 0.843
R-HSA-1489509 DAG and IP3 signaling 0.143539 0.843
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.148541 0.828
R-HSA-68882 Mitotic Anaphase 0.151120 0.821
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.152133 0.818
R-HSA-418990 Adherens junctions interactions 0.153148 0.815
R-HSA-5655253 Signaling by FGFR2 in disease 0.155990 0.807
R-HSA-8951664 Neddylation 0.156200 0.806
R-HSA-8878171 Transcriptional regulation by RUNX1 0.161314 0.792
R-HSA-162906 HIV Infection 0.162340 0.790
R-HSA-6798695 Neutrophil degranulation 0.163091 0.788
R-HSA-5654736 Signaling by FGFR1 0.170697 0.768
R-HSA-177929 Signaling by EGFR 0.170697 0.768
R-HSA-202733 Cell surface interactions at the vascular wall 0.172672 0.763
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.175543 0.756
R-HSA-157118 Signaling by NOTCH 0.175793 0.755
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.180362 0.744
R-HSA-5619115 Disorders of transmembrane transporters 0.183112 0.737
R-HSA-421270 Cell-cell junction organization 0.187316 0.727
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.187538 0.727
R-HSA-5688426 Deubiquitination 0.191534 0.718
R-HSA-1280218 Adaptive Immune System 0.198839 0.701
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.205557 0.687
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.208701 0.680
R-HSA-1266738 Developmental Biology 0.210357 0.677
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.211018 0.676
R-HSA-1226099 Signaling by FGFR in disease 0.213329 0.671
R-HSA-1280215 Cytokine Signaling in Immune system 0.213466 0.671
R-HSA-1169408 ISG15 antiviral mechanism 0.215634 0.666
R-HSA-917937 Iron uptake and transport 0.215634 0.666
R-HSA-446728 Cell junction organization 0.216021 0.666
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.217094 0.663
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.220314 0.657
R-HSA-383280 Nuclear Receptor transcription pathway 0.222508 0.653
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.224786 0.648
R-HSA-5673001 RAF/MAP kinase cascade 0.227844 0.642
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.229323 0.640
R-HSA-9707564 Cytoprotection by HMOX1 0.233834 0.631
R-HSA-1257604 PIP3 activates AKT signaling 0.234315 0.630
R-HSA-5684996 MAPK1/MAPK3 signaling 0.235395 0.628
R-HSA-195721 Signaling by WNT 0.237555 0.624
R-HSA-69278 Cell Cycle, Mitotic 0.244830 0.611
R-HSA-8986944 Transcriptional Regulation by MECP2 0.253815 0.595
R-HSA-1500931 Cell-Cell communication 0.257047 0.590
R-HSA-162582 Signal Transduction 0.267439 0.573
R-HSA-6807878 COPI-mediated anterograde transport 0.269002 0.570
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.269002 0.570
R-HSA-1474244 Extracellular matrix organization 0.273326 0.563
R-HSA-5683057 MAPK family signaling cascades 0.290688 0.537
R-HSA-9692914 SARS-CoV-1-host interactions 0.292258 0.534
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.294336 0.531
R-HSA-9700206 Signaling by ALK in cancer 0.294336 0.531
R-HSA-211000 Gene Silencing by RNA 0.294336 0.531
R-HSA-2871796 FCERI mediated MAPK activation 0.304637 0.516
R-HSA-1483249 Inositol phosphate metabolism 0.304637 0.516
R-HSA-212436 Generic Transcription Pathway 0.308829 0.510
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.314790 0.502
R-HSA-2029485 Role of phospholipids in phagocytosis 0.314790 0.502
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.314790 0.502
R-HSA-1592230 Mitochondrial biogenesis 0.318811 0.496
R-HSA-68886 M Phase 0.329567 0.482
R-HSA-6809371 Formation of the cornified envelope 0.332702 0.478
R-HSA-194138 Signaling by VEGF 0.336619 0.473
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.338570 0.470
R-HSA-8956319 Nucleotide catabolism 0.344387 0.463
R-HSA-1640170 Cell Cycle 0.358615 0.445
R-HSA-74160 Gene expression (Transcription) 0.360593 0.443
R-HSA-9018519 Estrogen-dependent gene expression 0.361541 0.442
R-HSA-72766 Translation 0.379484 0.421
R-HSA-199977 ER to Golgi Anterograde Transport 0.383731 0.416
R-HSA-73857 RNA Polymerase II Transcription 0.384892 0.415
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.396325 0.402
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.396325 0.402
R-HSA-9664433 Leishmania parasite growth and survival 0.430935 0.366
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.430935 0.366
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.432613 0.364
R-HSA-9824446 Viral Infection Pathways 0.433641 0.363
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.474594 0.324
R-HSA-428157 Sphingolipid metabolism 0.476146 0.322
R-HSA-948021 Transport to the Golgi and subsequent modification 0.477694 0.321
R-HSA-6805567 Keratinization 0.485367 0.314
R-HSA-9679506 SARS-CoV Infections 0.504769 0.297
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.520687 0.283
R-HSA-15869 Metabolism of nucleotides 0.529139 0.276
R-HSA-8939211 ESR-mediated signaling 0.530534 0.275
R-HSA-597592 Post-translational protein modification 0.551344 0.259
R-HSA-71291 Metabolism of amino acids and derivatives 0.561299 0.251
R-HSA-168249 Innate Immune System 0.562962 0.250
R-HSA-382551 Transport of small molecules 0.566526 0.247
R-HSA-449147 Signaling by Interleukins 0.567301 0.246
R-HSA-5663205 Infectious disease 0.568845 0.245
R-HSA-211945 Phase I - Functionalization of compounds 0.584355 0.233
R-HSA-199991 Membrane Trafficking 0.586618 0.232
R-HSA-9658195 Leishmania infection 0.588047 0.231
R-HSA-9824443 Parasitic Infection Pathways 0.588047 0.231
R-HSA-1852241 Organelle biogenesis and maintenance 0.633218 0.198
R-HSA-212165 Epigenetic regulation of gene expression 0.636485 0.196
R-HSA-8957322 Metabolism of steroids 0.637567 0.195
R-HSA-9694516 SARS-CoV-2 Infection 0.663627 0.178
R-HSA-9006931 Signaling by Nuclear Receptors 0.677411 0.169
R-HSA-196854 Metabolism of vitamins and cofactors 0.678374 0.169
R-HSA-109582 Hemostasis 0.688155 0.162
R-HSA-5653656 Vesicle-mediated transport 0.703855 0.153
R-HSA-168256 Immune System 0.729017 0.137
R-HSA-446203 Asparagine N-linked glycosylation 0.730479 0.136
R-HSA-1643685 Disease 0.750714 0.125
R-HSA-211859 Biological oxidations 0.801153 0.096
R-HSA-1430728 Metabolism 0.801927 0.096
R-HSA-556833 Metabolism of lipids 0.829176 0.081
R-HSA-392499 Metabolism of proteins 0.856855 0.067
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.689 0.417 1 0.857
CDK18CDK18 0.685 0.443 1 0.863
HIPK2HIPK2 0.684 0.430 1 0.846
CLK3CLK3 0.683 0.289 1 0.714
CDK19CDK19 0.680 0.431 1 0.871
P38DP38D 0.679 0.456 1 0.884
CDK17CDK17 0.678 0.440 1 0.861
CDK1CDK1 0.678 0.418 1 0.864
CDK16CDK16 0.678 0.426 1 0.859
CDK3CDK3 0.677 0.385 1 0.873
P38GP38G 0.676 0.442 1 0.872
CDK8CDK8 0.675 0.418 1 0.866
DYRK2DYRK2 0.674 0.415 1 0.825
CDK5CDK5 0.674 0.404 1 0.847
HIPK1HIPK1 0.672 0.396 1 0.815
DYRK1BDYRK1B 0.670 0.399 1 0.837
SRPK1SRPK1 0.669 0.248 -3 0.748
DYRK4DYRK4 0.668 0.408 1 0.873
ERK1ERK1 0.667 0.425 1 0.865
CDK7CDK7 0.666 0.410 1 0.866
CDK12CDK12 0.666 0.422 1 0.865
CDK13CDK13 0.666 0.412 1 0.863
JNK2JNK2 0.666 0.432 1 0.871
HIPK4HIPK4 0.666 0.313 1 0.684
P38BP38B 0.666 0.430 1 0.868
CDK14CDK14 0.663 0.427 1 0.841
CDK10CDK10 0.663 0.397 1 0.846
P38AP38A 0.663 0.426 1 0.832
DYRK1ADYRK1A 0.661 0.364 1 0.808
CLK2CLK2 0.661 0.242 -3 0.765
SRPK2SRPK2 0.660 0.206 -3 0.691
JNK3JNK3 0.659 0.414 1 0.872
HIPK3HIPK3 0.658 0.389 1 0.786
CLK1CLK1 0.658 0.266 -3 0.728
CDK9CDK9 0.656 0.398 1 0.861
NLKNLK 0.656 0.344 1 0.722
COTCOT 0.652 -0.031 2 0.692
CDKL5CDKL5 0.652 0.167 -3 0.751
SRPK3SRPK3 0.652 0.194 -3 0.715
CDK6CDK6 0.651 0.392 1 0.849
ERK2ERK2 0.650 0.397 1 0.832
DYRK3DYRK3 0.650 0.308 1 0.788
PRP4PRP4 0.650 0.298 -3 0.726
CDKL1CDKL1 0.650 0.155 -3 0.757
ICKICK 0.650 0.245 -3 0.775
ERK5ERK5 0.649 0.217 1 0.677
CLK4CLK4 0.648 0.221 -3 0.754
CDK2CDK2 0.648 0.304 1 0.806
CDK4CDK4 0.648 0.404 1 0.860
MAKMAK 0.647 0.314 -2 0.719
MOSMOS 0.645 0.062 1 0.544
JNK1JNK1 0.644 0.368 1 0.872
NUAK2NUAK2 0.642 0.071 -3 0.777
CDC7CDC7 0.638 0.007 1 0.529
MTORMTOR 0.638 0.070 1 0.543
MOKMOK 0.637 0.288 1 0.741
PKN3PKN3 0.635 0.029 -3 0.756
PIM3PIM3 0.634 -0.009 -3 0.795
DSTYKDSTYK 0.633 -0.051 2 0.679
MAPKAPK2MAPKAPK2 0.633 0.065 -3 0.727
PIM1PIM1 0.633 0.038 -3 0.769
PRPKPRPK 0.633 -0.055 -1 0.575
BMPR1BBMPR1B 0.632 0.032 1 0.489
MAPKAPK3MAPKAPK3 0.632 0.056 -3 0.733
ERK7ERK7 0.631 0.152 2 0.472
ATRATR 0.631 -0.012 1 0.475
CAMK1BCAMK1B 0.631 0.028 -3 0.781
CHK1CHK1 0.631 0.130 -3 0.737
PRKD1PRKD1 0.630 0.030 -3 0.756
NIKNIK 0.630 0.029 -3 0.778
FAM20CFAM20C 0.629 0.042 2 0.545
LATS1LATS1 0.628 0.026 -3 0.785
BMPR2BMPR2 0.628 -0.070 -2 0.787
RAF1RAF1 0.628 -0.095 1 0.436
PRKD2PRKD2 0.628 0.045 -3 0.747
AMPKA1AMPKA1 0.627 0.052 -3 0.778
GRK7GRK7 0.627 0.014 1 0.455
AMPKA2AMPKA2 0.626 0.062 -3 0.765
PKCDPKCD 0.626 -0.008 2 0.621
NUAK1NUAK1 0.626 0.056 -3 0.745
MST4MST4 0.626 -0.021 2 0.652
TSSK2TSSK2 0.625 0.010 -5 0.170
NEK6NEK6 0.625 -0.034 -2 0.766
TGFBR2TGFBR2 0.625 -0.030 -2 0.741
CHAK2CHAK2 0.624 -0.016 -1 0.579
MLK1MLK1 0.624 -0.068 2 0.619
GCN2GCN2 0.624 -0.104 2 0.567
TBK1TBK1 0.624 -0.101 1 0.364
IKKBIKKB 0.624 -0.101 -2 0.647
DAPK2DAPK2 0.623 0.011 -3 0.772
PKN2PKN2 0.623 -0.027 -3 0.760
NDR2NDR2 0.623 -0.053 -3 0.779
ATMATM 0.622 -0.014 1 0.434
PDHK4PDHK4 0.621 -0.086 1 0.488
SKMLCKSKMLCK 0.621 -0.032 -2 0.707
PKCGPKCG 0.621 -0.012 2 0.594
IRE2IRE2 0.621 -0.034 2 0.609
CAMLCKCAMLCK 0.620 0.003 -2 0.695
MLK3MLK3 0.620 -0.027 2 0.582
RSK2RSK2 0.620 0.006 -3 0.752
ULK2ULK2 0.620 -0.145 2 0.590
P90RSKP90RSK 0.620 0.008 -3 0.757
IKKEIKKE 0.620 -0.108 1 0.365
PKCBPKCB 0.619 -0.007 2 0.580
NDR1NDR1 0.619 -0.062 -3 0.776
MLK4MLK4 0.619 -0.039 2 0.557
LATS2LATS2 0.618 -0.054 -5 0.075
RSK3RSK3 0.618 0.000 -3 0.737
PHKG1PHKG1 0.618 -0.001 -3 0.769
TSSK1TSSK1 0.618 -0.002 -3 0.794
ACVR2BACVR2B 0.618 0.001 -2 0.754
P70S6KBP70S6KB 0.618 -0.016 -3 0.755
CAMK2GCAMK2G 0.618 -0.090 2 0.602
ALK4ALK4 0.618 -0.000 -2 0.751
PRKD3PRKD3 0.617 0.028 -3 0.713
RIPK3RIPK3 0.617 -0.074 3 0.583
CAMK2ACAMK2A 0.617 0.010 2 0.586
PDHK1PDHK1 0.617 -0.114 1 0.465
ANKRD3ANKRD3 0.617 -0.071 1 0.453
MARK4MARK4 0.616 -0.043 4 0.654
GRK1GRK1 0.616 -0.052 -2 0.670
CAMK2DCAMK2D 0.616 -0.020 -3 0.745
ACVR2AACVR2A 0.616 -0.008 -2 0.747
TGFBR1TGFBR1 0.616 0.003 -2 0.736
CAMK2BCAMK2B 0.616 -0.001 2 0.577
PKCAPKCA 0.616 -0.011 2 0.575
SBKSBK 0.616 0.124 -3 0.615
WNK1WNK1 0.615 -0.048 -2 0.728
BMPR1ABMPR1A 0.615 0.013 1 0.486
GRK5GRK5 0.615 -0.118 -3 0.724
IKKAIKKA 0.614 -0.081 -2 0.665
DLKDLK 0.614 -0.117 1 0.456
PINK1PINK1 0.614 0.090 1 0.559
MLK2MLK2 0.614 -0.092 2 0.619
AKT2AKT2 0.614 0.048 -3 0.694
PIM2PIM2 0.614 0.028 -3 0.723
NEK7NEK7 0.613 -0.135 -3 0.675
PKCZPKCZ 0.613 -0.030 2 0.612
IRE1IRE1 0.613 -0.053 1 0.375
GRK6GRK6 0.612 -0.083 1 0.468
PLK1PLK1 0.612 -0.064 -2 0.755
SIKSIK 0.612 0.012 -3 0.721
YSK4YSK4 0.612 -0.077 1 0.393
CAMK4CAMK4 0.611 -0.025 -3 0.745
MELKMELK 0.611 0.006 -3 0.750
QSKQSK 0.611 0.004 4 0.656
MNK1MNK1 0.611 -0.014 -2 0.650
NEK9NEK9 0.611 -0.110 2 0.615
TAO3TAO3 0.610 -0.017 1 0.430
RSK4RSK4 0.610 -0.002 -3 0.740
PKRPKR 0.610 -0.046 1 0.423
BCKDKBCKDK 0.610 -0.100 -1 0.571
PKCHPKCH 0.610 -0.029 2 0.562
ULK1ULK1 0.610 -0.136 -3 0.660
ALK2ALK2 0.610 -0.008 -2 0.724
HUNKHUNK 0.609 -0.125 2 0.582
DCAMKL1DCAMKL1 0.608 0.007 -3 0.759
MASTLMASTL 0.608 -0.148 -2 0.716
AURCAURC 0.608 -0.005 -2 0.466
BRSK1BRSK1 0.608 0.015 -3 0.744
BRAFBRAF 0.607 -0.044 -4 0.633
TTBK2TTBK2 0.607 -0.123 2 0.519
BUB1BUB1 0.606 0.075 -5 0.173
CAMK1GCAMK1G 0.605 0.014 -3 0.728
MAPKAPK5MAPKAPK5 0.605 0.015 -3 0.677
MEKK2MEKK2 0.605 -0.049 2 0.592
QIKQIK 0.605 -0.046 -3 0.726
CHAK1CHAK1 0.605 -0.086 2 0.617
MSK2MSK2 0.605 -0.013 -3 0.716
PAK1PAK1 0.605 -0.054 -2 0.633
CHK2CHK2 0.604 0.077 -3 0.652
DCAMKL2DCAMKL2 0.604 0.011 -3 0.763
ZAKZAK 0.604 -0.088 1 0.419
SGK3SGK3 0.604 -0.005 -3 0.718
MEK1MEK1 0.604 -0.110 2 0.610
NIM1NIM1 0.604 -0.084 3 0.612
MNK2MNK2 0.604 -0.035 -2 0.634
GSK3AGSK3A 0.604 0.058 4 0.236
PKACGPKACG 0.604 -0.048 -2 0.539
GRK4GRK4 0.603 -0.124 -2 0.718
VRK2VRK2 0.603 -0.092 1 0.530
PKCTPKCT 0.603 -0.026 2 0.566
MEKK1MEKK1 0.603 -0.084 1 0.423
PKACBPKACB 0.602 -0.000 -2 0.478
PASKPASK 0.602 -0.008 -3 0.773
MARK3MARK3 0.602 -0.023 4 0.597
MST3MST3 0.602 -0.039 2 0.643
TLK1TLK1 0.602 -0.054 -2 0.753
MYLK4MYLK4 0.601 -0.014 -2 0.592
AKT1AKT1 0.601 0.026 -3 0.703
MEKK3MEKK3 0.601 -0.103 1 0.418
CK2A2CK2A2 0.601 0.010 1 0.458
MARK2MARK2 0.601 -0.028 4 0.563
PAK3PAK3 0.601 -0.074 -2 0.633
PKCEPKCE 0.601 0.014 2 0.584
DRAK1DRAK1 0.601 -0.091 1 0.411
DNAPKDNAPK 0.601 -0.033 1 0.379
SMMLCKSMMLCK 0.601 0.003 -3 0.747
PLK3PLK3 0.600 -0.078 2 0.569
CAMK1DCAMK1D 0.600 0.037 -3 0.679
PRKXPRKX 0.600 0.017 -3 0.694
CK1ECK1E 0.600 -0.011 -3 0.506
CK1DCK1D 0.600 0.015 -3 0.462
NEK2NEK2 0.599 -0.090 2 0.616
NEK5NEK5 0.599 -0.071 1 0.404
PKCIPKCI 0.599 -0.009 2 0.593
EEF2KEEF2K 0.599 0.005 3 0.674
GRK2GRK2 0.599 -0.056 -2 0.594
WNK3WNK3 0.599 -0.188 1 0.401
HRIHRI 0.599 -0.070 -2 0.779
MEK5MEK5 0.599 -0.109 2 0.606
RIPK1RIPK1 0.599 -0.125 1 0.395
DAPK3DAPK3 0.599 0.010 -3 0.767
PLK4PLK4 0.599 -0.098 2 0.452
PKN1PKN1 0.598 0.020 -3 0.690
BRSK2BRSK2 0.598 -0.037 -3 0.743
TAO2TAO2 0.598 -0.026 2 0.657
PHKG2PHKG2 0.598 -0.022 -3 0.738
PERKPERK 0.598 -0.082 -2 0.760
MPSK1MPSK1 0.597 0.009 1 0.431
TNIKTNIK 0.597 0.003 3 0.721
TLK2TLK2 0.597 -0.094 1 0.376
GCKGCK 0.596 -0.023 1 0.392
MARK1MARK1 0.596 -0.032 4 0.620
MST2MST2 0.596 -0.058 1 0.408
SMG1SMG1 0.595 -0.067 1 0.431
SSTKSSTK 0.595 -0.066 4 0.636
IRAK4IRAK4 0.595 -0.090 1 0.376
MSK1MSK1 0.595 -0.014 -3 0.719
PAK2PAK2 0.594 -0.082 -2 0.620
AKT3AKT3 0.594 0.031 -3 0.656
SGK1SGK1 0.594 0.040 -3 0.639
AURBAURB 0.594 -0.031 -2 0.464
NEK8NEK8 0.594 -0.090 2 0.628
PKG2PKG2 0.594 -0.034 -2 0.468
CAMK1ACAMK1A 0.594 0.042 -3 0.667
CK1A2CK1A2 0.593 0.001 -3 0.467
PDK1PDK1 0.593 -0.040 1 0.440
SNRKSNRK 0.592 -0.106 2 0.497
PAK6PAK6 0.592 -0.031 -2 0.544
KHS2KHS2 0.592 0.014 1 0.382
HGKHGK 0.592 -0.026 3 0.709
WNK4WNK4 0.591 -0.082 -2 0.727
NEK11NEK11 0.591 -0.074 1 0.417
GAKGAK 0.591 -0.037 1 0.483
MINKMINK 0.591 -0.043 1 0.375
AURAAURA 0.591 -0.041 -2 0.450
HASPINHASPIN 0.591 0.059 -1 0.568
MAP3K15MAP3K15 0.591 -0.054 1 0.414
LKB1LKB1 0.590 -0.040 -3 0.689
KHS1KHS1 0.590 -0.010 1 0.375
TTKTTK 0.590 0.019 -2 0.769
DAPK1DAPK1 0.589 -0.003 -3 0.750
CK2A1CK2A1 0.589 -0.007 1 0.443
P70S6KP70S6K 0.589 -0.032 -3 0.678
LRRK2LRRK2 0.588 -0.008 2 0.643
OSR1OSR1 0.588 -0.033 2 0.589
GRK3GRK3 0.588 -0.057 -2 0.551
PKACAPKACA 0.587 -0.003 -2 0.422
MEKK6MEKK6 0.587 -0.073 1 0.420
HPK1HPK1 0.587 -0.034 1 0.384
MST1MST1 0.586 -0.075 1 0.379
ALPHAK3ALPHAK3 0.584 0.008 -1 0.530
PLK2PLK2 0.583 -0.050 -3 0.637
SLKSLK 0.583 -0.043 -2 0.630
NEK4NEK4 0.583 -0.091 1 0.363
CAMKK1CAMKK1 0.583 -0.124 -2 0.645
CK1G1CK1G1 0.583 -0.049 -3 0.523
PBKPBK 0.582 -0.017 1 0.434
PAK5PAK5 0.582 -0.035 -2 0.508
LOKLOK 0.582 -0.049 -2 0.656
ROCK2ROCK2 0.582 -0.021 -3 0.748
NEK1NEK1 0.581 -0.061 1 0.376
IRAK1IRAK1 0.580 -0.135 -1 0.446
YSK1YSK1 0.580 -0.052 2 0.602
GSK3BGSK3B 0.580 -0.034 4 0.225
DMPK1DMPK1 0.580 0.014 -3 0.742
CAMKK2CAMKK2 0.579 -0.107 -2 0.642
MRCKBMRCKB 0.579 -0.014 -3 0.711
NEK3NEK3 0.576 -0.035 1 0.396
TTBK1TTBK1 0.576 -0.135 2 0.477
TAO1TAO1 0.576 -0.028 1 0.366
PAK4PAK4 0.575 -0.044 -2 0.510
TAK1TAK1 0.574 -0.126 1 0.407
AAK1AAK1 0.574 0.036 1 0.381
BIKEBIKE 0.573 -0.001 1 0.423
MRCKAMRCKA 0.573 -0.039 -3 0.723
MYO3BMYO3B 0.572 -0.015 2 0.643
CRIKCRIK 0.572 0.004 -3 0.699
VRK1VRK1 0.571 -0.165 2 0.659
MYO3AMYO3A 0.570 -0.038 1 0.358
ASK1ASK1 0.570 -0.077 1 0.418
YANK3YANK3 0.570 -0.031 2 0.333
PDHK3_TYRPDHK3_TYR 0.569 0.038 4 0.714
ROCK1ROCK1 0.568 -0.027 -3 0.726
STK33STK33 0.567 -0.116 2 0.471
TESK1_TYRTESK1_TYR 0.567 0.021 3 0.697
RIPK2RIPK2 0.567 -0.145 1 0.384
MAP2K4_TYRMAP2K4_TYR 0.566 0.032 -1 0.606
PDHK4_TYRPDHK4_TYR 0.565 0.008 2 0.668
PKMYT1_TYRPKMYT1_TYR 0.565 0.061 3 0.669
EPHA6EPHA6 0.565 0.002 -1 0.625
LIMK2_TYRLIMK2_TYR 0.565 0.052 -3 0.765
PDHK1_TYRPDHK1_TYR 0.564 0.005 -1 0.630
EPHB4EPHB4 0.564 0.003 -1 0.583
MAP2K6_TYRMAP2K6_TYR 0.564 0.002 -1 0.623
CK1ACK1A 0.563 -0.024 -3 0.400
BMPR2_TYRBMPR2_TYR 0.563 0.015 -1 0.634
BLKBLK 0.563 0.018 -1 0.533
MEK2MEK2 0.563 -0.174 2 0.575
JAK3JAK3 0.562 -0.004 1 0.447
PINK1_TYRPINK1_TYR 0.562 -0.038 1 0.486
CSF1RCSF1R 0.562 -0.002 3 0.675
LCKLCK 0.562 0.015 -1 0.515
ABL2ABL2 0.562 0.005 -1 0.495
ROS1ROS1 0.560 -0.027 3 0.655
INSRRINSRR 0.560 -0.022 3 0.616
MST1RMST1R 0.560 -0.009 3 0.698
RETRET 0.558 -0.053 1 0.436
JAK2JAK2 0.558 -0.010 1 0.452
LIMK1_TYRLIMK1_TYR 0.557 -0.017 2 0.653
MAP2K7_TYRMAP2K7_TYR 0.556 -0.105 2 0.639
TYRO3TYRO3 0.556 -0.064 3 0.678
TXKTXK 0.556 -0.030 1 0.502
PKG1PKG1 0.555 -0.038 -2 0.387
METMET 0.555 -0.025 3 0.677
JAK1JAK1 0.555 0.014 1 0.396
TNNI3K_TYRTNNI3K_TYR 0.555 -0.003 1 0.459
KDRKDR 0.555 -0.016 3 0.637
STLK3STLK3 0.554 -0.113 1 0.380
EPHA4EPHA4 0.553 -0.007 2 0.586
KITKIT 0.553 -0.040 3 0.664
TYK2TYK2 0.553 -0.083 1 0.427
FGRFGR 0.553 -0.053 1 0.454
FGFR2FGFR2 0.552 -0.018 3 0.637
EPHB3EPHB3 0.552 -0.036 -1 0.565
ABL1ABL1 0.552 -0.019 -1 0.472
FGFR1FGFR1 0.552 -0.003 3 0.641
EPHB2EPHB2 0.552 -0.029 -1 0.561
ITKITK 0.551 -0.060 -1 0.454
HCKHCK 0.551 -0.031 -1 0.500
FLT3FLT3 0.551 -0.062 3 0.678
TNK2TNK2 0.550 -0.034 3 0.635
EPHB1EPHB1 0.549 -0.059 1 0.491
PDGFRBPDGFRB 0.549 -0.079 3 0.678
FERFER 0.549 -0.064 1 0.504
TEKTEK 0.548 -0.022 3 0.612
YES1YES1 0.548 -0.073 -1 0.505
INSRINSR 0.547 -0.049 3 0.606
FLT1FLT1 0.546 -0.042 -1 0.617
FGFR3FGFR3 0.545 -0.029 3 0.621
FYNFYN 0.544 -0.028 -1 0.511
BMXBMX 0.544 -0.055 -1 0.404
PTK2PTK2 0.544 0.015 -1 0.600
TNK1TNK1 0.544 -0.034 3 0.648
PDGFRAPDGFRA 0.544 -0.064 3 0.678
FRKFRK 0.544 -0.028 -1 0.529
ALKALK 0.543 -0.067 3 0.611
EPHA7EPHA7 0.543 -0.041 2 0.592
DDR1DDR1 0.543 -0.117 4 0.608
EPHA8EPHA8 0.543 -0.013 -1 0.568
NTRK3NTRK3 0.543 -0.046 -1 0.533
LYNLYN 0.543 -0.039 3 0.588
NEK10_TYRNEK10_TYR 0.543 -0.050 1 0.364
SYKSYK 0.543 0.000 -1 0.599
EGFREGFR 0.543 -0.032 1 0.385
EPHA5EPHA5 0.542 -0.025 2 0.571
YANK2YANK2 0.542 -0.047 2 0.348
CK1G3CK1G3 0.542 -0.038 -3 0.365
SRMSSRMS 0.541 -0.090 1 0.486
MERTKMERTK 0.540 -0.077 3 0.644
MATKMATK 0.539 -0.054 -1 0.462
TECTEC 0.539 -0.076 -1 0.379
FLT4FLT4 0.538 -0.064 3 0.581
AXLAXL 0.538 -0.092 3 0.658
NTRK1NTRK1 0.538 -0.097 -1 0.556
EPHA1EPHA1 0.538 -0.068 3 0.680
EPHA3EPHA3 0.538 -0.070 2 0.560
NTRK2NTRK2 0.537 -0.089 3 0.632
PTK2BPTK2B 0.537 -0.044 -1 0.422
FGFR4FGFR4 0.537 -0.033 -1 0.513
ERBB4ERBB4 0.537 -0.021 1 0.405
ERBB2ERBB2 0.536 -0.076 1 0.417
ZAP70ZAP70 0.536 -0.003 -1 0.506
DDR2DDR2 0.535 -0.040 3 0.606
LTKLTK 0.535 -0.105 3 0.608
CK1G2CK1G2 0.535 -0.039 -3 0.444
IGF1RIGF1R 0.535 -0.057 3 0.549
EPHA2EPHA2 0.535 -0.029 -1 0.553
WEE1_TYRWEE1_TYR 0.534 -0.061 -1 0.451
SRCSRC 0.532 -0.076 -1 0.488
MUSKMUSK 0.531 -0.054 1 0.355
BTKBTK 0.530 -0.126 -1 0.396
CSKCSK 0.527 -0.078 2 0.584
PTK6PTK6 0.525 -0.140 -1 0.388
FESFES 0.506 -0.086 -1 0.377