Motif 1205 (n=44)

Position-wise Probabilities
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uniprot genes site source protein function
C9JAW5 None S8 ochoa HIG1 domain-containing protein None
O43299 AP5Z1 S8 ochoa AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.
O43929 ORC4 S8 ochoa Origin recognition complex subunit 4 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.
O60716 CTNND1 S8 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75563 SKAP2 S8 ochoa Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.
O75821 EIF3G S8 ochoa Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
O75909 CCNK S8 ochoa Cyclin-K Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}.
O95379 TNFAIP8 S8 ochoa Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.
O95786 RIGI S8 ochoa|psp Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:34935440, ECO:0000269|PubMed:35263596, ECO:0000269|PubMed:36793726, ECO:0000269|Ref.74, ECO:0000303|PubMed:21616437, ECO:0000303|PubMed:21884169}.
O96028 NSD2 S8 ochoa Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}.
P06454 PTMA T8 ochoa Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
P13807 GYS1 S8 ochoa|psp Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}.
P19388 POLR2E Y8 ochoa DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. {ECO:0000250|UniProtKB:P20434, ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000269|PubMed:9852112}.
P23381 WARS1 S8 ochoa Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.
P30519 HMOX2 S8 ochoa Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form] [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}.
P40121 CAPG S8 ochoa Macrophage-capping protein (Actin regulatory protein CAP-G) Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
P50151 GNG10 S8 ochoa Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.
P55010 EIF5 S8 ochoa Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
P78362 SRPK2 S8 ochoa SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.
Q13615 MTMR3 S8 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}.
Q14202 ZMYM3 S8 ochoa Zinc finger MYM-type protein 3 (Zinc finger protein 261) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q15020 SART3 S8 ochoa Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}.
Q5T0W9 FAM83B S8 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q86WR7 PROSER2 S8 ochoa Proline and serine-rich protein 2 None
Q8TAA9 VANGL1 S8 ochoa Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) None
Q8TBE0 BAHD1 S8 ochoa Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}.
Q92613 JADE3 S8 ochoa Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.
Q96CC6 RHBDF1 S8 ochoa Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}.
Q96CP6 GRAMD1A S8 ochoa Protein Aster-A (GRAM domain-containing protein 1A) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.
Q96MY1 NOL4L S8 ochoa Nucleolar protein 4-like None
Q9C004 SPRY4 S8 ochoa Protein sprouty homolog 4 (Spry-4) Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}.
Q9H3R0 KDM4C S8 ochoa Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
Q9H8E8 KAT14 S8 ochoa Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269|PubMed:19103755}.
Q9HCS7 XAB2 S8 ochoa Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). {ECO:0000269|PubMed:10944529, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:17981804, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Q9NUJ3 TCP11L1 S8 ochoa T-complex protein 11-like protein 1 None
Q9NWZ3 IRAK4 S8 psp Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}.
Q9NYA4 MTMR4 S8 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}.
Q9NZT2 OGFR S8 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9UMX3 BOK S8 ochoa Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9) [Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:15102863, PubMed:20673843, PubMed:27076518). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:15102863, PubMed:27076518). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). {ECO:0000250|UniProtKB:O35425, ECO:0000269|PubMed:15102863, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843, ECO:0000269|PubMed:24113155, ECO:0000269|PubMed:27076518}.; FUNCTION: [Isoform 2]: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. {ECO:0000269|PubMed:15775999}.
Q9Y241 HIGD1A S8 ochoa HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.
Q9Y287 ITM2B S8 ochoa Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
P61024 CKS1B Y8 Sugiyama Cyclin-dependent kinases regulatory subunit 1 (CKS-1) Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
P21108 PRPS1L1 S8 Sugiyama Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III) Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
P60891 PRPS1 S8 Sugiyama Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}.
Download
reactome_id name p -log10_p
R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 0.000612 3.213
R-HSA-1483255 PI Metabolism 0.000369 3.433
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.000951 3.022
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.002019 2.695
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.002202 2.657
R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.011854 1.926
R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.011854 1.926
R-HSA-5603037 IRAK4 deficiency (TLR5) 0.014796 1.830
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.023570 1.628
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.026478 1.577
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.032268 1.491
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.040890 1.388
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.043747 1.359
R-HSA-167287 HIV elongation arrest and recovery 0.004714 2.327
R-HSA-167290 Pausing and recovery of HIV elongation 0.004714 2.327
R-HSA-8964315 G beta:gamma signalling through BTK 0.055093 1.259
R-HSA-73780 RNA Polymerase III Chain Elongation 0.055093 1.259
R-HSA-418217 G beta:gamma signalling through PLC beta 0.066307 1.178
R-HSA-73980 RNA Polymerase III Transcription Termination 0.066307 1.178
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.008790 2.056
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.069090 1.161
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.011451 1.941
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.077391 1.111
R-HSA-6803529 FGFR2 alternative splicing 0.080141 1.096
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.082884 1.082
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.082884 1.082
R-HSA-112382 Formation of RNA Pol II elongation complex 0.013979 1.855
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.014421 1.841
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.088346 1.054
R-HSA-1296059 G protein gated Potassium channels 0.088346 1.054
R-HSA-1296041 Activation of G protein gated Potassium channels 0.088346 1.054
R-HSA-72702 Ribosomal scanning and start codon recognition 0.015785 1.802
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.015785 1.802
R-HSA-6782135 Dual incision in TC-NER 0.016724 1.777
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.093775 1.028
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.093775 1.028
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.096478 1.016
R-HSA-113418 Formation of the Early Elongation Complex 0.096478 1.016
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.025619 1.591
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.120451 0.919
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.136086 0.866
R-HSA-167161 HIV Transcription Initiation 0.136086 0.866
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.136086 0.866
R-HSA-73776 RNA Polymerase II Promoter Escape 0.141237 0.850
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.146358 0.835
R-HSA-72165 mRNA Splicing - Minor Pathway 0.148907 0.827
R-HSA-73772 RNA Polymerase I Promoter Escape 0.164047 0.785
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.166544 0.778
R-HSA-72163 mRNA Splicing - Major Pathway 0.132698 0.877
R-HSA-72172 mRNA Splicing 0.143851 0.842
R-HSA-167172 Transcription of the HIV genome 0.021764 1.662
R-HSA-167169 HIV Transcription Elongation 0.130905 0.883
R-HSA-72086 mRNA Capping 0.099173 1.004
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.130905 0.883
R-HSA-8964616 G beta:gamma signalling through CDC42 0.060716 1.217
R-HSA-202040 G-protein activation 0.074632 1.127
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.032817 1.484
R-HSA-9762292 Regulation of CDH11 function 0.038024 1.420
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.040890 1.388
R-HSA-397795 G-protein beta:gamma signalling 0.109874 0.959
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.128303 0.892
R-HSA-68962 Activation of the pre-replicative complex 0.101860 0.992
R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.074632 1.127
R-HSA-428930 Thromboxane signalling through TP receptor 0.085619 1.067
R-HSA-73863 RNA Polymerase I Transcription Termination 0.093775 1.028
R-HSA-74158 RNA Polymerase III Transcription 0.120451 0.919
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.025052 1.601
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.104539 0.981
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.091064 1.041
R-HSA-392518 Signal amplification 0.115178 0.939
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.060716 1.217
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.069090 1.161
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.130905 0.883
R-HSA-162599 Late Phase of HIV Life Cycle 0.082510 1.083
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.143801 0.842
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.060716 1.217
R-HSA-933541 TRAF6 mediated IRF7 activation 0.123076 0.910
R-HSA-68689 CDC6 association with the ORC:origin complex 0.023570 1.628
R-HSA-500657 Presynaptic function of Kainate receptors 0.066307 1.178
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.069090 1.161
R-HSA-3322077 Glycogen synthesis 0.071865 1.143
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.077391 1.111
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.080141 1.096
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.082884 1.082
R-HSA-933542 TRAF6 mediated NF-kB activation 0.085619 1.067
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.138666 0.858
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.101860 0.992
R-HSA-5696398 Nucleotide Excision Repair 0.047776 1.321
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.085619 1.067
R-HSA-1296065 Inwardly rectifying K+ channels 0.107211 0.970
R-HSA-3229121 Glycogen storage diseases 0.063516 1.197
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.080141 1.096
R-HSA-9634597 GPER1 signaling 0.153983 0.813
R-HSA-162587 HIV Life Cycle 0.096020 1.018
R-HSA-72737 Cap-dependent Translation Initiation 0.057576 1.240
R-HSA-72613 Eukaryotic Translation Initiation 0.057576 1.240
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.101860 0.992
R-HSA-991365 Activation of GABAB receptors 0.138666 0.858
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.063516 1.197
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.138666 0.858
R-HSA-977444 GABA B receptor activation 0.138666 0.858
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.148907 0.827
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.049978 1.301
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.077391 1.111
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.153983 0.813
R-HSA-8982491 Glycogen metabolism 0.130905 0.883
R-HSA-162906 HIV Infection 0.167771 0.775
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.099173 1.004
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.133500 0.875
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.109874 0.959
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.109874 0.959
R-HSA-113510 E2F mediated regulation of DNA replication 0.069090 1.161
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.130905 0.883
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.146358 0.835
R-HSA-68949 Orc1 removal from chromatin 0.164047 0.785
R-HSA-3214841 PKMTs methylate histone lysines 0.133500 0.875
R-HSA-176187 Activation of ATR in response to replication stress 0.109874 0.959
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.023570 1.628
R-HSA-391160 Signal regulatory protein family interactions 0.052269 1.282
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.146358 0.835
R-HSA-9766229 Degradation of CDH1 0.156510 0.805
R-HSA-69206 G1/S Transition 0.065549 1.183
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.018672 1.729
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.115178 0.939
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.133500 0.875
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.096478 1.016
R-HSA-9833109 Evasion by RSV of host interferon responses 0.104539 0.981
R-HSA-163359 Glucagon signaling in metabolic regulation 0.112530 0.949
R-HSA-69481 G2/M Checkpoints 0.067186 1.173
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.088346 1.054
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.091064 1.041
R-HSA-5260271 Diseases of Immune System 0.130905 0.883
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.130905 0.883
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.086051 1.065
R-HSA-3214847 HATs acetylate histones 0.042784 1.369
R-HSA-73894 DNA Repair 0.104093 0.983
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.088346 1.054
R-HSA-420092 Glucagon-type ligand receptors 0.099173 1.004
R-HSA-3214842 HDMs demethylate histones 0.088346 1.054
R-HSA-69231 Cyclin D associated events in G1 0.143801 0.842
R-HSA-69236 G1 Phase 0.143801 0.842
R-HSA-9864848 Complex IV assembly 0.161542 0.792
R-HSA-3247509 Chromatin modifying enzymes 0.006935 2.159
R-HSA-71336 Pentose phosphate pathway 0.008436 2.074
R-HSA-9707564 Cytoprotection by HMOX1 0.030338 1.518
R-HSA-69242 S Phase 0.087839 1.056
R-HSA-4839726 Chromatin organization 0.008446 2.073
R-HSA-9694631 Maturation of nucleoprotein 0.069090 1.161
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.080141 1.096
R-HSA-5689896 Ovarian tumor domain proteases 0.123076 0.910
R-HSA-72766 Translation 0.150285 0.823
R-HSA-8983711 OAS antiviral response 0.046596 1.332
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.088346 1.054
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.117819 0.929
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.133500 0.875
R-HSA-1839126 FGFR2 mutant receptor activation 0.120451 0.919
R-HSA-1483257 Phospholipid metabolism 0.014383 1.842
R-HSA-1640170 Cell Cycle 0.065114 1.186
R-HSA-1234174 Cellular response to hypoxia 0.020193 1.695
R-HSA-379716 Cytosolic tRNA aminoacylation 0.138666 0.858
R-HSA-189483 Heme degradation 0.112530 0.949
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.141237 0.850
R-HSA-611105 Respiratory electron transport 0.116872 0.932
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.123076 0.910
R-HSA-5655253 Signaling by FGFR2 in disease 0.159030 0.799
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.164047 0.785
R-HSA-3700989 Transcriptional Regulation by TP53 0.056525 1.248
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.041397 1.383
R-HSA-9006936 Signaling by TGFB family members 0.098794 1.005
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.168916 0.772
R-HSA-72649 Translation initiation complex formation 0.169034 0.772
R-HSA-418597 G alpha (z) signalling events 0.171517 0.766
R-HSA-177929 Signaling by EGFR 0.173993 0.759
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.173993 0.759
R-HSA-9764561 Regulation of CDH1 Function 0.176461 0.753
R-HSA-8939211 ESR-mediated signaling 0.178383 0.749
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.178923 0.747
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.181376 0.741
R-HSA-977443 GABA receptor activation 0.183823 0.736
R-HSA-379724 tRNA Aminoacylation 0.183823 0.736
R-HSA-168325 Viral Messenger RNA Synthesis 0.186263 0.730
R-HSA-445717 Aquaporin-mediated transport 0.186263 0.730
R-HSA-5693606 DNA Double Strand Break Response 0.200751 0.697
R-HSA-69620 Cell Cycle Checkpoints 0.200994 0.697
R-HSA-69202 Cyclin E associated events during G1/S transition 0.207900 0.682
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.207900 0.682
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.210270 0.677
R-HSA-427413 NoRC negatively regulates rRNA expression 0.210270 0.677
R-HSA-189445 Metabolism of porphyrins 0.210270 0.677
R-HSA-9711123 Cellular response to chemical stress 0.211885 0.674
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.212632 0.672
R-HSA-5578749 Transcriptional regulation by small RNAs 0.212632 0.672
R-HSA-4086398 Ca2+ pathway 0.214987 0.668
R-HSA-69052 Switching of origins to a post-replicative state 0.214987 0.668
R-HSA-5663084 Diseases of carbohydrate metabolism 0.214987 0.668
R-HSA-69473 G2/M DNA damage checkpoint 0.217335 0.663
R-HSA-1226099 Signaling by FGFR in disease 0.217335 0.663
R-HSA-1169408 ISG15 antiviral mechanism 0.219677 0.658
R-HSA-917937 Iron uptake and transport 0.219677 0.658
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.222011 0.654
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.223936 0.650
R-HSA-9694635 Translation of Structural Proteins 0.224339 0.649
R-HSA-73864 RNA Polymerase I Transcription 0.226660 0.645
R-HSA-416482 G alpha (12/13) signalling events 0.226660 0.645
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.231282 0.636
R-HSA-5654738 Signaling by FGFR2 0.231282 0.636
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.231282 0.636
R-HSA-5693607 Processing of DNA double-strand break ends 0.233582 0.632
R-HSA-977225 Amyloid fiber formation 0.233582 0.632
R-HSA-390466 Chaperonin-mediated protein folding 0.249499 0.603
R-HSA-69278 Cell Cycle, Mitotic 0.254677 0.594
R-HSA-373080 Class B/2 (Secretin family receptors) 0.256221 0.591
R-HSA-391251 Protein folding 0.262884 0.580
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.262884 0.580
R-HSA-1500931 Cell-Cell communication 0.264805 0.577
R-HSA-68867 Assembly of the pre-replicative complex 0.265092 0.577
R-HSA-8953897 Cellular responses to stimuli 0.266083 0.575
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.269488 0.569
R-HSA-72689 Formation of a pool of free 40S subunits 0.271677 0.566
R-HSA-212165 Epigenetic regulation of gene expression 0.272563 0.565
R-HSA-1296071 Potassium Channels 0.273859 0.562
R-HSA-157579 Telomere Maintenance 0.276035 0.559
R-HSA-422356 Regulation of insulin secretion 0.278204 0.556
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.278204 0.556
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.278204 0.556
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.278204 0.556
R-HSA-190236 Signaling by FGFR 0.278204 0.556
R-HSA-9020702 Interleukin-1 signaling 0.284674 0.546
R-HSA-9009391 Extra-nuclear estrogen signaling 0.284674 0.546
R-HSA-111885 Opioid Signalling 0.291087 0.536
R-HSA-9860931 Response of endothelial cells to shear stress 0.291087 0.536
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.292504 0.534
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.292894 0.533
R-HSA-5619507 Activation of HOX genes during differentiation 0.293213 0.533
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.293213 0.533
R-HSA-9833110 RSV-host interactions 0.293213 0.533
R-HSA-418346 Platelet homeostasis 0.297444 0.527
R-HSA-9692914 SARS-CoV-1-host interactions 0.297444 0.527
R-HSA-211000 Gene Silencing by RNA 0.299551 0.524
R-HSA-69239 Synthesis of DNA 0.299551 0.524
R-HSA-9694516 SARS-CoV-2 Infection 0.301353 0.521
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.301651 0.520
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.301651 0.520
R-HSA-69002 DNA Replication Pre-Initiation 0.303746 0.517
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.303746 0.517
R-HSA-1483249 Inositol phosphate metabolism 0.309991 0.509
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.312061 0.506
R-HSA-9855142 Cellular responses to mechanical stimuli 0.314125 0.503
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.314125 0.503
R-HSA-9006931 Signaling by Nuclear Receptors 0.316799 0.499
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.318234 0.497
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.318234 0.497
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.320279 0.494
R-HSA-5693538 Homology Directed Repair 0.326380 0.486
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.328401 0.484
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.328401 0.484
R-HSA-73886 Chromosome Maintenance 0.332426 0.478
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.334430 0.476
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.334430 0.476
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.336428 0.473
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.336428 0.473
R-HSA-194138 Signaling by VEGF 0.342387 0.465
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.352201 0.453
R-HSA-163685 Integration of energy metabolism 0.367607 0.435
R-HSA-3858494 Beta-catenin independent WNT signaling 0.367607 0.435
R-HSA-9018519 Estrogen-dependent gene expression 0.367607 0.435
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.369507 0.432
R-HSA-2262752 Cellular responses to stress 0.375159 0.426
R-HSA-1632852 Macroautophagy 0.377053 0.424
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.380793 0.419
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.391880 0.407
R-HSA-446652 Interleukin-1 family signaling 0.399163 0.399
R-HSA-5693532 DNA Double-Strand Break Repair 0.400970 0.397
R-HSA-69306 DNA Replication 0.400970 0.397
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.402773 0.395
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.402773 0.395
R-HSA-5663205 Infectious disease 0.402997 0.395
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.404569 0.393
R-HSA-9612973 Autophagy 0.406361 0.391
R-HSA-162582 Signal Transduction 0.425060 0.372
R-HSA-418555 G alpha (s) signalling events 0.434317 0.362
R-HSA-5689880 Ub-specific processing proteases 0.437720 0.359
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.437720 0.359
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.437720 0.359
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.437720 0.359
R-HSA-9664433 Leishmania parasite growth and survival 0.437720 0.359
R-HSA-9678108 SARS-CoV-1 Infection 0.441102 0.355
R-HSA-168255 Influenza Infection 0.447808 0.349
R-HSA-9824446 Viral Infection Pathways 0.449813 0.347
R-HSA-168898 Toll-like Receptor Cascades 0.467455 0.330
R-HSA-68877 Mitotic Prometaphase 0.470662 0.327
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.475438 0.323
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.501713 0.300
R-HSA-418990 Adherens junctions interactions 0.510675 0.292
R-HSA-9679506 SARS-CoV Infections 0.516027 0.287
R-HSA-9705683 SARS-CoV-2-host interactions 0.525262 0.280
R-HSA-421270 Cell-cell junction organization 0.557216 0.254
R-HSA-5688426 Deubiquitination 0.562555 0.250
R-HSA-416476 G alpha (q) signalling events 0.574336 0.241
R-HSA-168249 Innate Immune System 0.579963 0.237
R-HSA-1430728 Metabolism 0.585504 0.232
R-HSA-76002 Platelet activation, signaling and aggregation 0.587062 0.231
R-HSA-446728 Cell junction organization 0.592047 0.228
R-HSA-9658195 Leishmania infection 0.595748 0.225
R-HSA-9824443 Parasitic Infection Pathways 0.595748 0.225
R-HSA-1257604 PIP3 activates AKT signaling 0.612586 0.213
R-HSA-195721 Signaling by WNT 0.616104 0.210
R-HSA-1643685 Disease 0.634635 0.197
R-HSA-112315 Transmission across Chemical Synapses 0.644228 0.191
R-HSA-9006925 Intracellular signaling by second messengers 0.664243 0.178
R-HSA-556833 Metabolism of lipids 0.669844 0.174
R-HSA-212436 Generic Transcription Pathway 0.702272 0.153
R-HSA-68886 M Phase 0.703751 0.153
R-HSA-913531 Interferon Signaling 0.704655 0.152
R-HSA-9824439 Bacterial Infection Pathways 0.710911 0.148
R-HSA-74160 Gene expression (Transcription) 0.723164 0.141
R-HSA-418594 G alpha (i) signalling events 0.725567 0.139
R-HSA-8953854 Metabolism of RNA 0.731516 0.136
R-HSA-5668914 Diseases of metabolism 0.741880 0.130
R-HSA-392499 Metabolism of proteins 0.751062 0.124
R-HSA-6798695 Neutrophil degranulation 0.764584 0.117
R-HSA-73857 RNA Polymerase II Transcription 0.766211 0.116
R-HSA-112316 Neuronal System 0.772409 0.112
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.803071 0.095
R-HSA-382551 Transport of small molecules 0.808381 0.092
R-HSA-500792 GPCR ligand binding 0.843332 0.074
R-HSA-1280215 Cytokine Signaling in Immune system 0.846755 0.072
R-HSA-449147 Signaling by Interleukins 0.859885 0.066
R-HSA-388396 GPCR downstream signalling 0.911984 0.040
R-HSA-109582 Hemostasis 0.914702 0.039
R-HSA-372790 Signaling by GPCR 0.932201 0.030
R-HSA-168256 Immune System 0.976420 0.010
R-HSA-1266738 Developmental Biology 0.985270 0.006
R-HSA-597592 Post-translational protein modification 0.994952 0.002
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.777 0.233 1 0.698
COTCOT 0.772 0.120 2 0.594
SKMLCKSKMLCK 0.766 0.213 -2 0.822
GRK1GRK1 0.766 0.152 -2 0.756
CDC7CDC7 0.765 0.080 1 0.641
PIM3PIM3 0.765 0.136 -3 0.760
MOSMOS 0.765 0.119 1 0.681
BMPR1BBMPR1B 0.763 0.247 1 0.657
KISKIS 0.763 0.101 1 0.591
IKKBIKKB 0.761 0.050 -2 0.675
RAF1RAF1 0.761 0.111 1 0.671
FAM20CFAM20C 0.759 0.086 2 0.498
GRK6GRK6 0.758 0.131 1 0.649
TBK1TBK1 0.758 0.035 1 0.590
CAMK2GCAMK2G 0.758 0.028 2 0.620
HIPK4HIPK4 0.758 0.123 1 0.674
PRPKPRPK 0.757 -0.051 -1 0.784
CAMK1BCAMK1B 0.757 0.098 -3 0.791
NDR2NDR2 0.757 0.050 -3 0.733
IKKAIKKA 0.756 0.076 -2 0.647
ERK5ERK5 0.755 0.073 1 0.733
IKKEIKKE 0.754 0.024 1 0.589
BMPR1ABMPR1A 0.754 0.222 1 0.618
CDKL1CDKL1 0.754 0.111 -3 0.742
CAMLCKCAMLCK 0.752 0.134 -2 0.823
GRK5GRK5 0.752 -0.006 -3 0.756
TGFBR1TGFBR1 0.752 0.172 -2 0.780
ICKICK 0.751 0.149 -3 0.757
ALK4ALK4 0.751 0.162 -2 0.808
MTORMTOR 0.751 -0.022 1 0.629
CHAK2CHAK2 0.751 0.057 -1 0.827
RSK2RSK2 0.750 0.125 -3 0.728
GRK7GRK7 0.750 0.152 1 0.585
MARK4MARK4 0.750 0.036 4 0.812
CDKL5CDKL5 0.750 0.119 -3 0.733
PIM1PIM1 0.750 0.114 -3 0.743
CLK2CLK2 0.749 0.206 -3 0.735
DAPK2DAPK2 0.749 0.138 -3 0.773
DYRK2DYRK2 0.749 0.113 1 0.618
DSTYKDSTYK 0.749 -0.016 2 0.612
BMPR2BMPR2 0.749 -0.061 -2 0.797
SRPK1SRPK1 0.749 0.084 -3 0.726
ATRATR 0.748 -0.026 1 0.602
GRK4GRK4 0.748 0.003 -2 0.757
NLKNLK 0.748 0.003 1 0.692
PAK1PAK1 0.747 0.121 -2 0.795
CLK4CLK4 0.746 0.171 -3 0.743
MYLK4MYLK4 0.746 0.165 -2 0.771
HIPK2HIPK2 0.746 0.125 1 0.553
AURAAURA 0.746 0.184 -2 0.680
GCN2GCN2 0.746 -0.164 2 0.571
HUNKHUNK 0.746 -0.044 2 0.597
MSK1MSK1 0.746 0.173 -3 0.702
AURCAURC 0.745 0.162 -2 0.693
PKACGPKACG 0.745 0.103 -2 0.732
PDHK4PDHK4 0.745 -0.192 1 0.675
RIPK3RIPK3 0.744 -0.018 3 0.640
ACVR2BACVR2B 0.744 0.145 -2 0.750
NDR1NDR1 0.744 0.012 -3 0.744
DYRK4DYRK4 0.744 0.135 1 0.556
PRKXPRKX 0.744 0.188 -3 0.664
PKACBPKACB 0.744 0.171 -2 0.687
LATS2LATS2 0.743 0.034 -5 0.621
LATS1LATS1 0.743 0.132 -3 0.735
ALK2ALK2 0.743 0.144 -2 0.786
PLK1PLK1 0.743 0.052 -2 0.716
P90RSKP90RSK 0.743 0.072 -3 0.721
CAMK2BCAMK2B 0.742 0.069 2 0.596
PRKD1PRKD1 0.742 0.037 -3 0.714
ATMATM 0.742 -0.013 1 0.525
ACVR2AACVR2A 0.742 0.117 -2 0.747
PKN3PKN3 0.742 -0.006 -3 0.735
CAMK2ACAMK2A 0.742 0.089 2 0.609
WNK1WNK1 0.741 -0.023 -2 0.804
MSK2MSK2 0.741 0.108 -3 0.695
RSK4RSK4 0.741 0.134 -3 0.691
TGFBR2TGFBR2 0.741 -0.011 -2 0.773
NUAK2NUAK2 0.741 0.015 -3 0.775
AMPKA1AMPKA1 0.741 0.025 -3 0.761
NIKNIK 0.741 -0.040 -3 0.777
CDK8CDK8 0.741 0.034 1 0.569
GRK2GRK2 0.740 0.057 -2 0.661
SRPK2SRPK2 0.740 0.075 -3 0.664
P38BP38B 0.740 0.107 1 0.580
MLK1MLK1 0.740 -0.095 2 0.532
PAK2PAK2 0.740 0.096 -2 0.793
P70S6KBP70S6KB 0.740 0.058 -3 0.741
PDHK1PDHK1 0.740 -0.173 1 0.662
PLK3PLK3 0.740 0.035 2 0.614
TSSK2TSSK2 0.740 0.017 -5 0.637
PAK3PAK3 0.739 0.067 -2 0.783
PASKPASK 0.739 0.193 -3 0.756
QSKQSK 0.739 0.057 4 0.788
PRKD2PRKD2 0.738 0.068 -3 0.701
MASTLMASTL 0.738 -0.152 -2 0.755
WNK3WNK3 0.738 -0.116 1 0.638
RSK3RSK3 0.738 0.064 -3 0.720
DLKDLK 0.738 -0.030 1 0.634
ANKRD3ANKRD3 0.738 -0.057 1 0.663
MARK3MARK3 0.737 0.068 4 0.767
TLK2TLK2 0.737 0.026 1 0.619
JNK3JNK3 0.737 0.075 1 0.562
ULK2ULK2 0.737 -0.215 2 0.545
DYRK1ADYRK1A 0.737 0.116 1 0.618
AURBAURB 0.737 0.141 -2 0.693
JNK2JNK2 0.737 0.085 1 0.543
BRSK1BRSK1 0.736 0.041 -3 0.723
CDK1CDK1 0.736 0.067 1 0.563
CK2A2CK2A2 0.736 0.136 1 0.572
MAPKAPK2MAPKAPK2 0.736 0.054 -3 0.678
HIPK1HIPK1 0.735 0.097 1 0.630
PAK6PAK6 0.735 0.121 -2 0.739
NIM1NIM1 0.735 -0.068 3 0.707
RIPK1RIPK1 0.735 -0.088 1 0.630
CLK1CLK1 0.735 0.130 -3 0.726
TSSK1TSSK1 0.735 0.028 -3 0.771
P38AP38A 0.735 0.079 1 0.636
CK1ECK1E 0.735 0.058 -3 0.580
BCKDKBCKDK 0.734 -0.128 -1 0.695
CDK7CDK7 0.734 0.024 1 0.585
ERK1ERK1 0.734 0.069 1 0.571
CAMK2DCAMK2D 0.734 -0.044 -3 0.733
CDK19CDK19 0.734 0.031 1 0.547
AMPKA2AMPKA2 0.734 0.020 -3 0.739
MARK2MARK2 0.733 0.043 4 0.737
PKN2PKN2 0.733 -0.018 -3 0.759
MLK3MLK3 0.733 -0.065 2 0.479
NEK6NEK6 0.732 -0.127 -2 0.750
PKCDPKCD 0.732 -0.010 2 0.511
MLK4MLK4 0.732 -0.045 2 0.478
NEK7NEK7 0.732 -0.184 -3 0.646
MEK1MEK1 0.732 -0.061 2 0.604
GRK3GRK3 0.731 0.051 -2 0.632
DYRK3DYRK3 0.731 0.133 1 0.628
MST4MST4 0.731 -0.073 2 0.543
SRPK3SRPK3 0.731 0.028 -3 0.701
CAMK4CAMK4 0.731 -0.011 -3 0.746
DYRK1BDYRK1B 0.731 0.081 1 0.591
P38GP38G 0.730 0.055 1 0.492
ERK2ERK2 0.730 0.038 1 0.595
P38DP38D 0.730 0.086 1 0.490
SIKSIK 0.730 0.022 -3 0.705
ULK1ULK1 0.730 -0.188 -3 0.639
PKACAPKACA 0.730 0.153 -2 0.641
MARK1MARK1 0.729 0.032 4 0.777
PIM2PIM2 0.729 0.078 -3 0.712
MAPKAPK3MAPKAPK3 0.729 -0.019 -3 0.697
CK2A1CK2A1 0.729 0.128 1 0.554
DRAK1DRAK1 0.729 0.047 1 0.587
CK1DCK1D 0.728 0.063 -3 0.538
TTBK2TTBK2 0.728 -0.155 2 0.504
PLK2PLK2 0.728 0.092 -3 0.694
IRE1IRE1 0.727 -0.118 1 0.648
HIPK3HIPK3 0.727 0.069 1 0.621
DNAPKDNAPK 0.727 -0.020 1 0.497
MLK2MLK2 0.726 -0.170 2 0.551
PKG2PKG2 0.726 0.091 -2 0.679
PRKD3PRKD3 0.726 0.031 -3 0.707
AKT2AKT2 0.726 0.104 -3 0.683
BRSK2BRSK2 0.726 -0.022 -3 0.730
QIKQIK 0.726 -0.061 -3 0.736
PINK1PINK1 0.725 -0.056 1 0.702
CK1A2CK1A2 0.725 0.057 -3 0.548
TLK1TLK1 0.725 -0.019 -2 0.745
CDK13CDK13 0.725 -0.014 1 0.563
VRK2VRK2 0.725 -0.167 1 0.685
CDK18CDK18 0.725 0.033 1 0.539
SNRKSNRK 0.725 -0.076 2 0.551
PLK4PLK4 0.725 -0.083 2 0.518
IRE2IRE2 0.725 -0.099 2 0.510
MELKMELK 0.724 -0.025 -3 0.725
SMG1SMG1 0.724 -0.071 1 0.558
YSK4YSK4 0.724 -0.081 1 0.603
MEKK3MEKK3 0.724 -0.046 1 0.631
PKRPKR 0.724 -0.095 1 0.684
JNK1JNK1 0.724 0.070 1 0.530
PRP4PRP4 0.723 -0.000 -3 0.636
MNK2MNK2 0.723 0.033 -2 0.763
GAKGAK 0.723 0.153 1 0.720
SGK3SGK3 0.723 0.063 -3 0.710
DAPK1DAPK1 0.723 0.167 -3 0.745
SMMLCKSMMLCK 0.723 0.089 -3 0.753
DAPK3DAPK3 0.723 0.144 -3 0.749
NUAK1NUAK1 0.723 -0.028 -3 0.725
GSK3AGSK3A 0.722 0.054 4 0.423
CAMK1GCAMK1G 0.722 0.026 -3 0.717
CDK17CDK17 0.721 0.023 1 0.496
MNK1MNK1 0.720 0.028 -2 0.763
CDK5CDK5 0.720 -0.005 1 0.604
MAKMAK 0.720 0.172 -2 0.783
CHAK1CHAK1 0.720 -0.133 2 0.559
CHK1CHK1 0.720 -0.044 -3 0.711
BRAFBRAF 0.720 -0.068 -4 0.722
DCAMKL1DCAMKL1 0.719 0.014 -3 0.728
CDK12CDK12 0.719 -0.010 1 0.541
PKCZPKCZ 0.719 -0.051 2 0.504
CK1G1CK1G1 0.718 0.005 -3 0.581
PKCGPKCG 0.718 -0.067 2 0.478
SSTKSSTK 0.718 -0.004 4 0.774
PAK4PAK4 0.718 0.098 -2 0.706
CDK14CDK14 0.717 0.042 1 0.575
NEK9NEK9 0.717 -0.285 2 0.539
GSK3BGSK3B 0.717 0.020 4 0.412
MEKK2MEKK2 0.717 -0.099 2 0.536
CAMK1DCAMK1D 0.716 0.060 -3 0.659
CDK3CDK3 0.716 0.031 1 0.513
CDK9CDK9 0.716 -0.031 1 0.570
PAK5PAK5 0.716 0.087 -2 0.699
PKCBPKCB 0.715 -0.074 2 0.452
CDK2CDK2 0.715 -0.030 1 0.612
DCAMKL2DCAMKL2 0.715 -0.004 -3 0.749
PKCHPKCH 0.715 -0.070 2 0.454
MPSK1MPSK1 0.715 0.023 1 0.687
MEK5MEK5 0.714 -0.198 2 0.573
PERKPERK 0.713 -0.174 -2 0.781
AKT1AKT1 0.713 0.093 -3 0.685
PHKG1PHKG1 0.712 -0.116 -3 0.742
WNK4WNK4 0.712 -0.124 -2 0.804
TAO3TAO3 0.712 -0.050 1 0.619
YANK3YANK3 0.712 0.040 2 0.354
P70S6KP70S6K 0.712 0.010 -3 0.670
PKCAPKCA 0.711 -0.080 2 0.454
CDK16CDK16 0.710 0.022 1 0.508
MAPKAPK5MAPKAPK5 0.710 -0.081 -3 0.654
MRCKAMRCKA 0.709 0.115 -3 0.707
MST3MST3 0.709 -0.070 2 0.556
SGK1SGK1 0.709 0.104 -3 0.620
NEK2NEK2 0.708 -0.199 2 0.538
HRIHRI 0.708 -0.216 -2 0.775
TTBK1TTBK1 0.708 -0.141 2 0.466
ZAKZAK 0.708 -0.189 1 0.573
MEKK1MEKK1 0.706 -0.227 1 0.620
GCKGCK 0.706 0.025 1 0.684
MRCKBMRCKB 0.706 0.101 -3 0.705
NEK8NEK8 0.706 -0.133 2 0.559
TAK1TAK1 0.706 0.012 1 0.650
CDK10CDK10 0.705 0.018 1 0.566
NEK5NEK5 0.705 -0.182 1 0.660
PDK1PDK1 0.705 -0.074 1 0.606
CHK2CHK2 0.704 0.058 -3 0.649
MOKMOK 0.704 0.094 1 0.670
ROCK2ROCK2 0.704 0.092 -3 0.728
IRAK4IRAK4 0.703 -0.163 1 0.636
ERK7ERK7 0.703 -0.041 2 0.338
AKT3AKT3 0.703 0.093 -3 0.629
SBKSBK 0.703 0.075 -3 0.593
CK1ACK1A 0.702 0.044 -3 0.473
LKB1LKB1 0.701 -0.112 -3 0.646
CAMKK1CAMKK1 0.701 -0.173 -2 0.652
NEK11NEK11 0.701 -0.156 1 0.619
DMPK1DMPK1 0.701 0.130 -3 0.737
MST2MST2 0.700 -0.065 1 0.657
PKCTPKCT 0.700 -0.073 2 0.456
SLKSLK 0.700 -0.020 -2 0.670
PHKG2PHKG2 0.700 -0.087 -3 0.752
PDHK3_TYRPDHK3_TYR 0.699 0.133 4 0.826
CAMKK2CAMKK2 0.699 -0.143 -2 0.663
STK33STK33 0.699 -0.107 2 0.482
MAP2K6_TYRMAP2K6_TYR 0.699 0.166 -1 0.796
HPK1HPK1 0.699 -0.006 1 0.670
IRAK1IRAK1 0.698 -0.240 -1 0.674
CAMK1ACAMK1A 0.698 0.039 -3 0.649
PKCIPKCI 0.698 -0.062 2 0.468
PKCEPKCE 0.697 -0.021 2 0.462
TAO2TAO2 0.697 -0.171 2 0.565
PBKPBK 0.696 0.023 1 0.682
LRRK2LRRK2 0.696 -0.150 2 0.591
PDHK1_TYRPDHK1_TYR 0.695 0.126 -1 0.817
PDHK4_TYRPDHK4_TYR 0.695 0.118 2 0.669
CDK4CDK4 0.695 -0.011 1 0.532
MINKMINK 0.694 -0.089 1 0.660
PKG1PKG1 0.694 0.069 -2 0.620
TNIKTNIK 0.694 -0.091 3 0.673
MST1MST1 0.693 -0.079 1 0.645
TTKTTK 0.693 -0.011 -2 0.750
BMPR2_TYRBMPR2_TYR 0.693 0.101 -1 0.794
PKN1PKN1 0.692 -0.026 -3 0.692
CDK6CDK6 0.692 -0.026 1 0.553
MAP3K15MAP3K15 0.692 -0.166 1 0.564
ALPHAK3ALPHAK3 0.692 0.034 -1 0.747
VRK1VRK1 0.691 -0.169 2 0.571
ROCK1ROCK1 0.691 0.083 -3 0.711
EEF2KEEF2K 0.690 -0.144 3 0.644
MAP2K4_TYRMAP2K4_TYR 0.690 0.019 -1 0.784
HGKHGK 0.690 -0.143 3 0.673
MEKK6MEKK6 0.689 -0.183 1 0.633
KHS1KHS1 0.689 -0.045 1 0.660
NEK4NEK4 0.689 -0.203 1 0.646
KHS2KHS2 0.689 -0.021 1 0.677
LOKLOK 0.688 -0.106 -2 0.709
MAP2K7_TYRMAP2K7_TYR 0.688 -0.099 2 0.645
EPHA6EPHA6 0.688 0.054 -1 0.808
CRIKCRIK 0.688 0.061 -3 0.672
BUB1BUB1 0.688 -0.016 -5 0.542
TESK1_TYRTESK1_TYR 0.687 -0.095 3 0.758
MEK2MEK2 0.686 -0.219 2 0.564
RIPK2RIPK2 0.686 -0.225 1 0.533
EPHA4EPHA4 0.685 0.051 2 0.635
EPHB4EPHB4 0.684 0.031 -1 0.787
PKMYT1_TYRPKMYT1_TYR 0.683 -0.130 3 0.738
CK1G3CK1G3 0.683 0.042 -3 0.439
INSRRINSRR 0.683 0.025 3 0.670
NEK1NEK1 0.682 -0.227 1 0.635
PINK1_TYRPINK1_TYR 0.682 -0.144 1 0.645
FERFER 0.681 -0.002 1 0.674
TXKTXK 0.681 0.094 1 0.668
DDR1DDR1 0.680 -0.050 4 0.795
HASPINHASPIN 0.679 -0.053 -1 0.630
YANK2YANK2 0.679 0.011 2 0.352
FGFR2FGFR2 0.678 -0.034 3 0.720
YES1YES1 0.678 0.006 -1 0.745
ABL2ABL2 0.678 0.003 -1 0.764
OSR1OSR1 0.678 -0.130 2 0.520
BIKEBIKE 0.677 0.019 1 0.650
SRMSSRMS 0.677 0.018 1 0.657
LIMK2_TYRLIMK2_TYR 0.676 -0.102 -3 0.740
EPHB2EPHB2 0.676 0.020 -1 0.776
RETRET 0.676 -0.117 1 0.605
EPHB1EPHB1 0.675 -0.002 1 0.639
CSF1RCSF1R 0.675 -0.065 3 0.672
KITKIT 0.675 -0.029 3 0.684
PTK2PTK2 0.674 0.104 -1 0.732
MST1RMST1R 0.674 -0.134 3 0.692
CK1G2CK1G2 0.674 0.050 -3 0.512
YSK1YSK1 0.674 -0.217 2 0.509
FGRFGR 0.674 -0.031 1 0.702
FGFR3FGFR3 0.674 -0.013 3 0.704
FYNFYN 0.673 0.078 -1 0.719
TYRO3TYRO3 0.673 -0.128 3 0.676
MYO3AMYO3A 0.673 -0.119 1 0.651
EPHB3EPHB3 0.672 -0.029 -1 0.771
ASK1ASK1 0.672 -0.189 1 0.541
METMET 0.672 -0.026 3 0.688
ROS1ROS1 0.672 -0.116 3 0.656
TNK2TNK2 0.672 -0.043 3 0.668
ABL1ABL1 0.671 -0.034 -1 0.749
MERTKMERTK 0.671 -0.030 3 0.689
BLKBLK 0.670 0.043 -1 0.743
ITKITK 0.670 -0.009 -1 0.728
KDRKDR 0.669 -0.069 3 0.667
BMXBMX 0.669 0.022 -1 0.693
MYO3BMYO3B 0.669 -0.140 2 0.552
EPHA3EPHA3 0.669 -0.040 2 0.618
JAK3JAK3 0.669 -0.106 1 0.561
EPHA7EPHA7 0.669 -0.015 2 0.621
PTK2BPTK2B 0.668 0.017 -1 0.694
LTKLTK 0.668 -0.054 3 0.662
DDR2DDR2 0.668 0.019 3 0.664
EPHA5EPHA5 0.668 0.012 2 0.633
FLT1FLT1 0.668 -0.026 -1 0.806
LCKLCK 0.668 -0.002 -1 0.752
LIMK1_TYRLIMK1_TYR 0.668 -0.268 2 0.608
TYK2TYK2 0.668 -0.237 1 0.610
HCKHCK 0.667 -0.061 -1 0.741
FGFR1FGFR1 0.667 -0.115 3 0.686
JAK2JAK2 0.667 -0.192 1 0.602
ALKALK 0.666 -0.073 3 0.642
PDGFRBPDGFRB 0.666 -0.156 3 0.690
ERBB2ERBB2 0.665 -0.083 1 0.563
TEKTEK 0.665 -0.115 3 0.653
FLT3FLT3 0.665 -0.124 3 0.671
FGFR4FGFR4 0.665 0.002 -1 0.751
PTK6PTK6 0.664 -0.100 -1 0.685
NTRK1NTRK1 0.664 -0.093 -1 0.775
SYKSYK 0.664 0.067 -1 0.750
TECTEC 0.664 -0.043 -1 0.668
EPHA8EPHA8 0.663 -0.013 -1 0.756
AXLAXL 0.663 -0.119 3 0.687
MATKMATK 0.663 -0.036 -1 0.734
INSRINSR 0.662 -0.078 3 0.638
SRCSRC 0.662 -0.000 -1 0.708
CSKCSK 0.661 -0.039 2 0.624
TAO1TAO1 0.661 -0.193 1 0.554
EGFREGFR 0.660 -0.030 1 0.466
FLT4FLT4 0.660 -0.104 3 0.660
IGF1RIGF1R 0.660 -0.016 3 0.612
TNK1TNK1 0.659 -0.123 3 0.672
STLK3STLK3 0.659 -0.207 1 0.551
EPHA2EPHA2 0.659 0.006 -1 0.755
FRKFRK 0.659 -0.062 -1 0.769
LYNLYN 0.658 -0.047 3 0.619
BTKBTK 0.658 -0.141 -1 0.703
NTRK3NTRK3 0.658 -0.079 -1 0.744
ERBB4ERBB4 0.657 -0.004 1 0.513
AAK1AAK1 0.656 0.037 1 0.590
NEK3NEK3 0.656 -0.330 1 0.581
WEE1_TYRWEE1_TYR 0.656 -0.114 -1 0.719
NTRK2NTRK2 0.655 -0.155 3 0.662
EPHA1EPHA1 0.655 -0.124 3 0.663
PDGFRAPDGFRA 0.653 -0.241 3 0.673
NEK10_TYRNEK10_TYR 0.652 -0.174 1 0.494
ZAP70ZAP70 0.649 0.029 -1 0.684
JAK1JAK1 0.649 -0.172 1 0.559
TNNI3K_TYRTNNI3K_TYR 0.647 -0.206 1 0.649
FESFES 0.646 -0.036 -1 0.670
MUSKMUSK 0.632 -0.176 1 0.469