Motif 1203 (n=106)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WTJ2 | GIMAP1-GIMAP5 | T8 | ochoa | GIMAP1-GIMAP5 readthrough | None |
| A6NKN8 | PCP4L1 | T8 | ochoa | Purkinje cell protein 4-like protein 1 (PCP4-like protein 1) | None |
| O15020 | SPTBN2 | T8 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15372 | EIF3H | T8 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O75530 | EED | T8 | ochoa | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}. |
| O76080 | ZFAND5 | T8 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94763 | URI1 | T8 | ochoa | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| O94887 | FARP2 | Y8 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95197 | RTN3 | T8 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| P02730 | SLC4A1 | Y8 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04080 | CSTB | T9 | ochoa | Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) | This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. |
| P04150 | NR3C1 | T8 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P05412 | JUN | T8 | psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P05783 | KRT18 | T8 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06454 | PTMA | T8 | ochoa | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. |
| P06730 | EIF4E | T8 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P09211 | GSTP1 | Y8 | ochoa|psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P09234 | SNRPC | Y8 | ochoa | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}. |
| P0C264 | SBK3 | T8 | ochoa | Uncharacterized serine/threonine-protein kinase SBK3 (EC 2.7.11.1) (SH3 domain-binding kinase family member 3) (Sugen kinase 110) | None |
| P13051 | UNG | Y8 | ochoa | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil residues arising as a result of misincorporation of dUMP residues by DNA polymerase during replication or due to spontaneous or enzymatic deamination of cytosine (PubMed:12958596, PubMed:15967827, PubMed:17101234, PubMed:22521144, PubMed:7671300, PubMed:8900285, PubMed:9016624, PubMed:9776759). Mediates error-free base excision repair (BER) of uracil at replication forks. According to the model, it is recruited by PCNA to S-phase replication forks to remove misincorporated uracil at U:A base mispairs in nascent DNA strands. Via trimeric RPA it is recruited to ssDNA stretches ahead of the polymerase to allow detection and excision of deaminated cytosines prior to replication. The resultant AP sites temporarily stall replication, allowing time to repair the lesion (PubMed:22521144). Mediates mutagenic uracil processing involved in antibody affinity maturation. Processes AICDA-induced U:G base mispairs at variable immunoglobulin (Ig) regions leading to the generation of transversion mutations (PubMed:12958596). Operates at switch sites of Ig constant regions where it mediates Ig isotype class switch recombination. Excises AICDA-induced uracil residues forming AP sites that are subsequently nicked by APEX1 endonuclease. The accumulation of staggered nicks in opposite strands results in double strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity) (PubMed:12958596). {ECO:0000250|UniProtKB:P97931, ECO:0000269|PubMed:12958596, ECO:0000269|PubMed:15967827, ECO:0000269|PubMed:17101234, ECO:0000269|PubMed:22521144, ECO:0000269|PubMed:7671300, ECO:0000269|PubMed:8900285, ECO:0000269|PubMed:9016624, ECO:0000269|PubMed:9776759}. |
| P16989 | YBX3 | T8 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P19388 | POLR2E | Y8 | ochoa | DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. {ECO:0000250|UniProtKB:P20434, ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000269|PubMed:9852112}. |
| P25490 | YY1 | Y8 | psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P26715 | KLRC1 | Y8 | psp | NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a) | Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:18083576, PubMed:37264229, PubMed:9430220, PubMed:9486650). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:12165520, PubMed:9485206). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:30860984, PubMed:9430220, PubMed:9485206, PubMed:9486650). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:30860984, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206, ECO:0000269|PubMed:9486650}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. Recognizes HLA-E in complex with human cytomegalovirus UL40-derived peptide (VMAPRTLIL) and inhibits NK cell cytotoxicity. {ECO:0000269|PubMed:10669413, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May recognize HLA-E in complex with HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32203188, PubMed:32859121). On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32203188, ECO:0000269|PubMed:32859121}. |
| P28066 | PSMA5 | Y8 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P37802 | TAGLN2 | Y8 | ochoa | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P45973 | CBX5 | T8 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P49321 | NASP | T8 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49356 | FNTB | T8 | ochoa | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}. |
| P49841 | GSK3B | T8 | ochoa | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P63010 | AP2B1 | T8 | ochoa | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P78347 | GTF2I | T8 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78358 | CTAG1A | T8 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
| P78508 | KCNJ10 | Y8 | psp | ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10) | May be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:8995301). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:8995301). The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:8995301). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). {ECO:0000250|UniProtKB:P49655, ECO:0000269|PubMed:8995301, ECO:0000305|PubMed:24561201}. |
| P84022 | SMAD3 | T8 | ochoa|psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| Q00341 | HDLBP | T8 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q04609 | FOLH1 | T8 | ochoa | Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Q10589 | BST2 | Y8 | ochoa | Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317) | IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:18200009, PubMed:18342597, PubMed:19036818, PubMed:19879838, PubMed:20019814, PubMed:20399176, PubMed:20419159, PubMed:20940320, PubMed:21529378, PubMed:22520941, PubMed:37922253). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:18200009, PubMed:18342597, PubMed:19179289, PubMed:19879838, PubMed:20399176, PubMed:20419159, PubMed:20686043, PubMed:20943977, PubMed:21529378, PubMed:21621240, PubMed:22520941, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328). {ECO:0000269|PubMed:18200009, ECO:0000269|PubMed:18342597, ECO:0000269|PubMed:19036818, ECO:0000269|PubMed:19179289, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:19879838, ECO:0000269|PubMed:20019814, ECO:0000269|PubMed:20399176, ECO:0000269|PubMed:20419159, ECO:0000269|PubMed:20686043, ECO:0000269|PubMed:20940320, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21529378, ECO:0000269|PubMed:21621240, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22520941, ECO:0000269|PubMed:23028328, ECO:0000269|PubMed:26172439, ECO:0000269|PubMed:26378163, ECO:0000269|PubMed:31199522, ECO:0000269|PubMed:37922253}. |
| Q12891 | HYAL2 | T8 | ochoa | Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) | Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210). {ECO:0000269|PubMed:28081210, ECO:0000269|PubMed:9712871}. |
| Q14694 | USP10 | Y8 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14749 | GNMT | T8 | psp | Glycine N-methyltransferase (EC 2.1.1.20) | Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. {ECO:0000269|PubMed:14651980, ECO:0000269|PubMed:14739680, ECO:0000269|PubMed:17660255, ECO:0000269|PubMed:8281755}. |
| Q14790 | CASP8 | Y8 | psp | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q15637 | SF1 | T8 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q15691 | MAPRE1 | T8 | ochoa | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q15742 | NAB2 | T8 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15796 | SMAD2 | T8 | ochoa|psp | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q7Z3C6 | ATG9A | Y8 | psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q86TI2 | DPP9 | T8 | ochoa | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:16475979, ECO:0000269|PubMed:19667070, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29382749, ECO:0000269|PubMed:29967349, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31525884, ECO:0000269|PubMed:32796818, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0000269|PubMed:36112693, ECO:0000269|PubMed:36357533}. |
| Q8IWA5 | SLC44A2 | Y8 | ochoa | Choline transporter-like protein 2 (Solute carrier family 44 member 2) | [Isoform 1]: Choline/H+ antiporter, mainly in mitochodria (PubMed:10677542, PubMed:20665236, PubMed:23651124, PubMed:33789160). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:33789160}.; FUNCTION: [Isoform 3]: Does not exhibit choline transporter activity. {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236}. |
| Q8IY67 | RAVER1 | T8 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IYE0 | CCDC146 | T8 | ochoa | Coiled-coil domain-containing protein 146 | Essential for sperm flagellum biogenesis and male fertility. {ECO:0000250|UniProtKB:E9Q9F7}. |
| Q8N3J5 | PPM1K | T8 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8N726 | CDKN2A | T8 | psp | Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) | Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. {ECO:0000250|UniProtKB:Q64364, ECO:0000269|PubMed:11314011, ECO:0000269|PubMed:11314038, ECO:0000269|PubMed:12660818, ECO:0000269|PubMed:14636574, ECO:0000269|PubMed:15361825, ECO:0000269|PubMed:15567177, ECO:0000269|PubMed:15876874, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:16713577, ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:9724636}.; FUNCTION: [Isoform smARF]: May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP. {ECO:0000269|PubMed:16713577}. |
| Q8N8F7 | LSMEM1 | T8 | ochoa | Leucine-rich single-pass membrane protein 1 | None |
| Q8TDH9 | BLOC1S5 | T8 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:32565547). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:32565547}. |
| Q8WWP7 | GIMAP1 | T8 | ochoa | GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1) | May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). {ECO:0000250}. |
| Q92609 | TBC1D5 | T8 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92826 | HOXB13 | T8 | psp | Homeobox protein Hox-B13 | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000269|PubMed:28473536}. |
| Q96C19 | EFHD2 | T8 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96D46 | NMD3 | T8 | ochoa | 60S ribosomal export protein NMD3 (hNMD3) | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. |
| Q96EW2 | HSPBAP1 | T8 | ochoa | HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1) | May play a role in cellular stress response. {ECO:0000250}. |
| Q96IZ0 | PAWR | T8 | ochoa | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q96S44 | TP53RK | T8 | ochoa | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). {ECO:0000250|UniProtKB:P53323, ECO:0000250|UniProtKB:Q9UYB9, ECO:0000269|PubMed:11546806, ECO:0000305|PubMed:22912744, ECO:0000305|PubMed:27903914}. |
| Q96S97 | MYADM | T8 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q99471 | PFDN5 | T8 | ochoa | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269|PubMed:9630229}. |
| Q9BR01 | SULT4A1 | T8 | psp | Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) | Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269|PubMed:17425406}. |
| Q9BR77 | CCDC77 | T8 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BTV4 | TMEM43 | T8 | ochoa | Transmembrane protein 43 (Protein LUMA) | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020). {ECO:0000250|UniProtKB:Q9DBS1, ECO:0000269|PubMed:27991920, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34050020}. |
| Q9BWQ6 | YIPF2 | T8 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9BZX2 | UCK2 | T8 | ochoa | Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702, ECO:0000269|PubMed:11494055}. |
| Q9H3U1 | UNC45A | T8 | ochoa | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993, ECO:0000305}. |
| Q9H4I2 | ZHX3 | T8 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H813 | PACC1 | T8 | ochoa | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) | Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}. |
| Q9NXW9 | ALKBH4 | T8 | ochoa | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q9D8F1, ECO:0000269|PubMed:23673617}. |
| Q9NYD6 | HOXC10 | T8 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9P253 | VPS18 | Y8 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9UBI6 | GNG12 | T8 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q9UHY1 | NRBP1 | T8 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UK41 | VPS28 | T8 | ochoa | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}. |
| Q9Y2Z0 | SUGT1 | T8 | ochoa | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y365 | STARD10 | T8 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y4P1 | ATG4B | Y8 | ochoa | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q9Y6D9 | MAD1L1 | T8 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| P08758 | ANXA5 | T8 | Sugiyama | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P61254 | RPL26 | T8 | Sugiyama | Large ribosomal subunit protein uL24 (60S ribosomal protein L26) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}. |
| Q9UNX3 | RPL26L1 | T8 | Sugiyama | Ribosomal protein uL24-like (60S ribosomal protein L26-like 1) (Large ribosomal subunit protein uL24-like 1) | None |
| Q13148 | TARDBP | T8 | SIGNOR | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| P61024 | CKS1B | Y8 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| Q15369 | ELOC | Y8 | Sugiyama | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:7821821}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:21199876, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:30166453, PubMed:33268465, PubMed:38326650, PubMed:35512830). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:36805027, PubMed:38177675). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:10205047, ECO:0000269|PubMed:12004076, ECO:0000269|PubMed:12050673, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:21199876, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0000269|PubMed:38326650}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:18562529, PubMed:20532212, PubMed:22190037, PubMed:24225024, PubMed:24402281, PubMed:36754086). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699). {ECO:0000269|PubMed:18562529, ECO:0000269|PubMed:20532212, ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:24225024, ECO:0000269|PubMed:24402281, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37640699}. |
| P61925 | PKIA | Y8 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| Q6P2M8 | PNCK | T8 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}. |
| O14818 | PSMA7 | T8 | Sugiyama | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q96GD4 | AURKB | Y8 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| P62491 | RAB11A | Y8 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P62820 | RAB1A | Y8 | ochoa | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:26209634}. |
| Q15907 | RAB11B | Y8 | ochoa | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173}. |
| Q96R06 | SPAG5 | S8 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| A1L429 | GAGE12B; | Y9 | Sugiyama | G antigen 12B/C/D/E (GAGE-12B) (GAGE-12C) (GAGE-12D) (GAGE-12E) | None |
| A6NDE8 | GAGE12H | Y9 | Sugiyama | G antigen 12H (GAGE-12H) | None |
| A6NER3 | GAGE12J | Y9 | Sugiyama | G antigen 12J (GAGE-12J) | None |
| O76087 | GAGE7 | Y9 | Sugiyama | G antigen 7 (GAGE-7) (AL4) (Cancer/testis antigen 4.7) (CT4.7) (GAGE-12I) (GAGE-7B) (GAGE-8) | None |
| P0CL80 | GAGE12F | Y9 | Sugiyama | G antigen 12F (GAGE-12F) | None |
| P0DSO3 | GAGE4 | Y9 | Sugiyama | G antigen 4 (Cancer/testis antigen 4.4) (CT4.4) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:7544395}. |
| Q13069 | GAGE5 | Y9 | Sugiyama | G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5) | None |
| Q13070 | GAGE6 | Y9 | Sugiyama | G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6) | None |
| P31689 | DNAJA1 | Y8 | Sugiyama | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.635810e-10 | 9.786 |
| R-HSA-212436 | Generic Transcription Pathway | 2.310694e-06 | 5.636 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.468088e-06 | 5.350 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.337975e-05 | 4.874 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.635068e-05 | 4.579 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 2.864403e-04 | 3.543 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 2.864403e-04 | 3.543 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 2.864403e-04 | 3.543 |
| R-HSA-2559583 | Cellular Senescence | 2.324215e-04 | 3.634 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.670122e-04 | 3.573 |
| R-HSA-74160 | Gene expression (Transcription) | 2.209901e-04 | 3.656 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 5.065416e-04 | 3.295 |
| R-HSA-9675132 | Diseases of cellular response to stress | 5.065416e-04 | 3.295 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 6.650563e-04 | 3.177 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 1.127740e-03 | 2.948 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.526899e-03 | 2.816 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.526899e-03 | 2.816 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.791355e-03 | 2.747 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.983826e-03 | 2.702 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 2.497580e-03 | 2.602 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.494251e-03 | 2.603 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.762011e-03 | 2.559 |
| R-HSA-9958517 | SLC-mediated bile acid transport | 3.691861e-03 | 2.433 |
| R-HSA-2262752 | Cellular responses to stress | 4.331796e-03 | 2.363 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.641534e-03 | 2.333 |
| R-HSA-9646304 | Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects | 8.040779e-03 | 2.095 |
| R-HSA-9646303 | Evasion of Oncogene Induced Senescence Due to p14ARF Defects | 8.040779e-03 | 2.095 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.777589e-03 | 2.057 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.292425e-03 | 2.276 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 8.882477e-03 | 2.051 |
| R-HSA-9796292 | Formation of axial mesoderm | 8.544163e-03 | 2.068 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.637395e-03 | 2.249 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 7.562733e-03 | 2.121 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 7.562733e-03 | 2.121 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 6.367062e-03 | 2.196 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 7.608332e-03 | 2.119 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 6.752012e-03 | 2.171 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 9.350428e-03 | 2.029 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 9.350428e-03 | 2.029 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.202477e-03 | 2.086 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.660566e-03 | 2.116 |
| R-HSA-69541 | Stabilization of p53 | 6.367062e-03 | 2.196 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.052689e-03 | 2.218 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.367062e-03 | 2.196 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 7.562733e-03 | 2.121 |
| R-HSA-1483191 | Synthesis of PC | 1.032891e-02 | 1.986 |
| R-HSA-1502540 | Signaling by Activin | 1.056155e-02 | 1.976 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.136468e-02 | 1.944 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.136468e-02 | 1.944 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.276773e-02 | 1.894 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.245831e-02 | 1.905 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.267339e-02 | 1.897 |
| R-HSA-9630791 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 | 1.601740e-02 | 1.795 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 1.601740e-02 | 1.795 |
| R-HSA-9632697 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 1.601740e-02 | 1.795 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.669681e-02 | 1.777 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.493873e-02 | 1.826 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.493873e-02 | 1.826 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.361027e-02 | 1.866 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.669681e-02 | 1.777 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.641687e-02 | 1.785 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.652854e-02 | 1.782 |
| R-HSA-162906 | HIV Infection | 1.552648e-02 | 1.809 |
| R-HSA-1266738 | Developmental Biology | 1.424507e-02 | 1.846 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.772074e-02 | 1.752 |
| R-HSA-1181150 | Signaling by NODAL | 1.772074e-02 | 1.752 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.164206e-02 | 1.665 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.164206e-02 | 1.665 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.176577e-02 | 1.662 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.810692e-02 | 1.742 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.188408e-02 | 1.660 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.952559e-02 | 1.709 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.045510e-02 | 1.689 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.988459e-02 | 1.701 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.028306e-02 | 1.693 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.045510e-02 | 1.689 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 2.393036e-02 | 1.621 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 2.393036e-02 | 1.621 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 2.393036e-02 | 1.621 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 2.393036e-02 | 1.621 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 2.393036e-02 | 1.621 |
| R-HSA-5688426 | Deubiquitination | 2.471691e-02 | 1.607 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.328257e-02 | 1.633 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.441719e-02 | 1.612 |
| R-HSA-9675108 | Nervous system development | 2.477431e-02 | 1.606 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.640945e-02 | 1.578 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.640945e-02 | 1.578 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.640945e-02 | 1.578 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.579893e-02 | 1.588 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.751692e-02 | 1.560 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.579893e-02 | 1.588 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.665046e-02 | 1.574 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.665046e-02 | 1.574 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.618105e-02 | 1.582 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.929460e-02 | 1.533 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.961786e-02 | 1.528 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.961786e-02 | 1.528 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.961786e-02 | 1.528 |
| R-HSA-1296067 | Potassium transport channels | 3.178018e-02 | 1.498 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 4.729236e-02 | 1.325 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 6.255790e-02 | 1.204 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 7.009940e-02 | 1.154 |
| R-HSA-3371378 | Regulation by c-FLIP | 8.500225e-02 | 1.071 |
| R-HSA-69416 | Dimerization of procaspase-8 | 8.500225e-02 | 1.071 |
| R-HSA-5218900 | CASP8 activity is inhibited | 9.236455e-02 | 1.034 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.069133e-01 | 0.971 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.069133e-01 | 0.971 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.069133e-01 | 0.971 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.141006e-01 | 0.943 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.212305e-01 | 0.916 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.212305e-01 | 0.916 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.212305e-01 | 0.916 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.212305e-01 | 0.916 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.212305e-01 | 0.916 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.212305e-01 | 0.916 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.127741e-02 | 1.505 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.127741e-02 | 1.505 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.353200e-01 | 0.869 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.422805e-01 | 0.847 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.422805e-01 | 0.847 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.422805e-01 | 0.847 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.491853e-01 | 0.826 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 4.386439e-02 | 1.358 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.695706e-01 | 0.771 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.695706e-01 | 0.771 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.588778e-02 | 1.253 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.762575e-01 | 0.754 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 6.228303e-02 | 1.206 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.024746e-01 | 0.694 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.088984e-01 | 0.680 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.088984e-01 | 0.680 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.088984e-01 | 0.680 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 8.521699e-02 | 1.069 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 8.763370e-02 | 1.057 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 8.763370e-02 | 1.057 |
| R-HSA-72649 | Translation initiation complex formation | 9.007083e-02 | 1.045 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.120139e-02 | 1.385 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.120139e-02 | 1.385 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 9.500444e-02 | 1.022 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.000141e-01 | 1.000 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.517944e-02 | 1.258 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.907068e-01 | 0.720 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.936175e-01 | 0.713 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.965339e-01 | 0.707 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.082526e-01 | 0.681 |
| R-HSA-167172 | Transcription of the HIV genome | 1.260781e-01 | 0.899 |
| R-HSA-167169 | HIV Transcription Elongation | 5.588778e-02 | 1.253 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.588778e-02 | 1.253 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.283035e-01 | 0.892 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.560350e-01 | 0.807 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.974293e-02 | 1.303 |
| R-HSA-202040 | G-protein activation | 1.894712e-01 | 0.722 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.069133e-01 | 0.971 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.381090e-02 | 1.269 |
| R-HSA-156902 | Peptide chain elongation | 1.849042e-01 | 0.733 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 9.500444e-02 | 1.022 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.424093e-01 | 0.846 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 6.255790e-02 | 1.204 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 1.894712e-01 | 0.722 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.826868e-02 | 1.417 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.828908e-01 | 0.738 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 4.729236e-02 | 1.325 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 7.758069e-02 | 1.110 |
| R-HSA-8849473 | PTK6 Expression | 7.758069e-02 | 1.110 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.401616e-01 | 0.853 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.369152e-01 | 0.864 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 7.758069e-02 | 1.110 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 9.236455e-02 | 1.034 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 1.762575e-01 | 0.754 |
| R-HSA-9907900 | Proteasome assembly | 6.667808e-02 | 1.176 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.826868e-02 | 1.417 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.159017e-02 | 1.210 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 6.255790e-02 | 1.204 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 9.966807e-02 | 1.001 |
| R-HSA-4839744 | Signaling by APC mutants | 1.069133e-01 | 0.971 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.141006e-01 | 0.943 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.141006e-01 | 0.943 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.212305e-01 | 0.916 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.283035e-01 | 0.892 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.646923e-02 | 1.438 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.491853e-01 | 0.826 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.695706e-01 | 0.771 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.762575e-01 | 0.754 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 7.117322e-02 | 1.148 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.959990e-01 | 0.708 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.024746e-01 | 0.694 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.088984e-01 | 0.680 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.994559e-01 | 0.700 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.341865e-01 | 0.872 |
| R-HSA-162587 | HIV Life Cycle | 1.688143e-01 | 0.773 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.353200e-01 | 0.869 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.491853e-01 | 0.826 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.628300e-01 | 0.788 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.024746e-01 | 0.694 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 1.560350e-01 | 0.807 |
| R-HSA-991365 | Activation of GABAB receptors | 6.228303e-02 | 1.206 |
| R-HSA-72766 | Translation | 7.318370e-02 | 1.136 |
| R-HSA-5689603 | UCH proteinases | 3.113178e-02 | 1.507 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.826868e-02 | 1.417 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.579331e-02 | 1.339 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.579331e-02 | 1.339 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.695706e-01 | 0.771 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.012441e-02 | 1.221 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.012441e-02 | 1.221 |
| R-HSA-977444 | GABA B receptor activation | 6.228303e-02 | 1.206 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.894712e-01 | 0.722 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 7.345699e-02 | 1.134 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 8.521699e-02 | 1.069 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.446777e-02 | 1.191 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.260781e-01 | 0.899 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.678186e-02 | 1.014 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 9.966807e-02 | 1.001 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.088984e-01 | 0.680 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.302826e-02 | 1.481 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.422805e-01 | 0.847 |
| R-HSA-4641258 | Degradation of DVL | 4.974293e-02 | 1.303 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.381090e-02 | 1.269 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.799247e-02 | 1.237 |
| R-HSA-9031628 | NGF-stimulated transcription | 7.576418e-02 | 1.121 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.891341e-02 | 1.162 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 3.178018e-02 | 1.498 |
| R-HSA-425381 | Bicarbonate transporters | 1.069133e-01 | 0.971 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 1.212305e-01 | 0.916 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.775303e-02 | 1.321 |
| R-HSA-4641257 | Degradation of AXIN | 4.974293e-02 | 1.303 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.024746e-01 | 0.694 |
| R-HSA-68949 | Orc1 removal from chromatin | 8.521699e-02 | 1.069 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 9.007083e-02 | 1.045 |
| R-HSA-977443 | GABA receptor activation | 1.050961e-01 | 0.978 |
| R-HSA-69236 | G1 Phase | 6.667808e-02 | 1.176 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.667808e-02 | 1.176 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.648216e-01 | 0.783 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 7.758069e-02 | 1.110 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 9.236455e-02 | 1.034 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.283035e-01 | 0.892 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.762575e-01 | 0.754 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.959990e-01 | 0.708 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.207413e-01 | 0.918 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.648978e-01 | 0.783 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.820128e-01 | 0.740 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.369152e-01 | 0.864 |
| R-HSA-195721 | Signaling by WNT | 1.159867e-01 | 0.936 |
| R-HSA-9758941 | Gastrulation | 4.714252e-02 | 1.327 |
| R-HSA-75157 | FasL/ CD95L signaling | 3.956735e-02 | 1.403 |
| R-HSA-8964011 | HDL clearance | 7.009940e-02 | 1.154 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.236455e-02 | 1.034 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.069133e-01 | 0.971 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.353200e-01 | 0.869 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.196690e-02 | 1.377 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.386439e-02 | 1.358 |
| R-HSA-169911 | Regulation of Apoptosis | 4.579331e-02 | 1.339 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 8.044679e-02 | 1.094 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 8.521699e-02 | 1.069 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.050961e-01 | 0.978 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.539523e-02 | 1.123 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.396563e-01 | 0.855 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.159017e-02 | 1.210 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.491853e-01 | 0.826 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.628300e-01 | 0.788 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.878023e-01 | 0.726 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.613154e-02 | 1.442 |
| R-HSA-75158 | TRAIL signaling | 6.255790e-02 | 1.204 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.212305e-01 | 0.916 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.381090e-02 | 1.269 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.588778e-02 | 1.253 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.799247e-02 | 1.237 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.799247e-02 | 1.237 |
| R-HSA-4086400 | PCP/CE pathway | 3.302826e-02 | 1.481 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 8.763370e-02 | 1.057 |
| R-HSA-68886 | M Phase | 1.089778e-01 | 0.963 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.120139e-02 | 1.385 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.076631e-01 | 0.968 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 9.252790e-02 | 1.034 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.000200e-01 | 1.000 |
| R-HSA-8964038 | LDL clearance | 2.024746e-01 | 0.694 |
| R-HSA-69242 | S Phase | 4.630061e-02 | 1.334 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.762575e-01 | 0.754 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.762575e-01 | 0.754 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.446777e-02 | 1.191 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.891341e-02 | 1.162 |
| R-HSA-391251 | Protein folding | 1.994559e-01 | 0.700 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.905276e-02 | 1.309 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 9.500444e-02 | 1.022 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.307856e-02 | 1.480 |
| R-HSA-1640170 | Cell Cycle | 3.448012e-02 | 1.462 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.099910e-01 | 0.959 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 7.758069e-02 | 1.110 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.695706e-01 | 0.771 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.762575e-01 | 0.754 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.891341e-02 | 1.162 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.959990e-01 | 0.708 |
| R-HSA-373755 | Semaphorin interactions | 1.128471e-01 | 0.948 |
| R-HSA-109581 | Apoptosis | 5.885873e-02 | 1.230 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.791283e-01 | 0.747 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.176242e-02 | 1.286 |
| R-HSA-5357801 | Programmed Cell Death | 1.100039e-01 | 0.959 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.212305e-01 | 0.916 |
| R-HSA-9664420 | Killing mechanisms | 1.491853e-01 | 0.826 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.491853e-01 | 0.826 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.560350e-01 | 0.807 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.799247e-02 | 1.237 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.894712e-01 | 0.722 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.891341e-02 | 1.162 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.643460e-02 | 1.248 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.310125e-01 | 0.883 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.154631e-01 | 0.938 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.028119e-02 | 1.220 |
| R-HSA-9824446 | Viral Infection Pathways | 4.439514e-02 | 1.353 |
| R-HSA-9766229 | Degradation of CDH1 | 7.809429e-02 | 1.107 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 8.282119e-02 | 1.082 |
| R-HSA-68882 | Mitotic Anaphase | 4.324597e-02 | 1.364 |
| R-HSA-422475 | Axon guidance | 4.058585e-02 | 1.392 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.389653e-02 | 1.358 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.274146e-01 | 0.895 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.827303e-01 | 0.738 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.387814e-02 | 1.131 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.475134e-02 | 1.459 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.552311e-01 | 0.809 |
| R-HSA-5663205 | Infectious disease | 1.478531e-01 | 0.830 |
| R-HSA-166520 | Signaling by NTRKs | 1.514163e-01 | 0.820 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.464234e-02 | 1.350 |
| R-HSA-8939211 | ESR-mediated signaling | 1.552129e-01 | 0.809 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 8.763370e-02 | 1.057 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.971929e-02 | 1.303 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.012881e-02 | 1.397 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.989956e-01 | 0.701 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.695706e-01 | 0.771 |
| R-HSA-8854214 | TBC/RABGAPs | 6.446777e-02 | 1.191 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.102469e-01 | 0.958 |
| R-HSA-6807070 | PTEN Regulation | 3.835035e-02 | 1.416 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.994559e-01 | 0.700 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.676665e-01 | 0.776 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 8.282119e-02 | 1.082 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.314705e-01 | 0.881 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.705200e-01 | 0.768 |
| R-HSA-69206 | G1/S Transition | 1.049582e-01 | 0.979 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.749999e-02 | 1.011 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.747397e-01 | 0.758 |
| R-HSA-351202 | Metabolism of polyamines | 1.050961e-01 | 0.978 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.765234e-01 | 0.753 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.043879e-02 | 1.044 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.126588e-01 | 0.948 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.088984e-01 | 0.680 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.341865e-01 | 0.872 |
| R-HSA-9824272 | Somitogenesis | 6.891341e-02 | 1.162 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.885187e-02 | 1.311 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.291240e-02 | 1.201 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 9.500444e-02 | 1.022 |
| R-HSA-5619084 | ABC transporter disorders | 1.535339e-01 | 0.814 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.023832e-01 | 0.694 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.031163e-01 | 0.692 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.031163e-01 | 0.692 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.698555e-01 | 0.770 |
| R-HSA-9612973 | Autophagy | 5.327378e-02 | 1.273 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.004716e-01 | 0.698 |
| R-HSA-202424 | Downstream TCR signaling | 1.907068e-01 | 0.720 |
| R-HSA-1632852 | Macroautophagy | 1.364760e-01 | 0.865 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.489893e-02 | 1.071 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.369152e-01 | 0.864 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.076631e-01 | 0.968 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 1.535339e-01 | 0.814 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.440222e-01 | 0.842 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.072571e-01 | 0.683 |
| R-HSA-9679506 | SARS-CoV Infections | 1.853019e-01 | 0.732 |
| R-HSA-157118 | Signaling by NOTCH | 1.597702e-01 | 0.797 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.111941e-01 | 0.675 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.141399e-01 | 0.669 |
| R-HSA-1296071 | Potassium Channels | 2.141399e-01 | 0.669 |
| R-HSA-429947 | Deadenylation of mRNA | 2.152709e-01 | 0.667 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.152709e-01 | 0.667 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.152709e-01 | 0.667 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.152709e-01 | 0.667 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.152709e-01 | 0.667 |
| R-HSA-168255 | Influenza Infection | 2.155958e-01 | 0.666 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.170896e-01 | 0.663 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.200430e-01 | 0.657 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.200430e-01 | 0.657 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.200430e-01 | 0.657 |
| R-HSA-2160916 | Hyaluronan degradation | 2.215925e-01 | 0.654 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.215925e-01 | 0.654 |
| R-HSA-9839394 | TGFBR3 expression | 2.215925e-01 | 0.654 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.215925e-01 | 0.654 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.230092e-01 | 0.652 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.240055e-01 | 0.650 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.259599e-01 | 0.646 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.278635e-01 | 0.642 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.278635e-01 | 0.642 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.278635e-01 | 0.642 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.289230e-01 | 0.640 |
| R-HSA-69275 | G2/M Transition | 2.303555e-01 | 0.638 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.340844e-01 | 0.631 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.340844e-01 | 0.631 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.340844e-01 | 0.631 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.340844e-01 | 0.631 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.346077e-01 | 0.630 |
| R-HSA-192823 | Viral mRNA Translation | 2.348571e-01 | 0.629 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.378277e-01 | 0.624 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.402045e-01 | 0.619 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.402556e-01 | 0.619 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.402556e-01 | 0.619 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.402556e-01 | 0.619 |
| R-HSA-622312 | Inflammasomes | 2.402556e-01 | 0.619 |
| R-HSA-73614 | Pyrimidine salvage | 2.402556e-01 | 0.619 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.402556e-01 | 0.619 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.437748e-01 | 0.613 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.437748e-01 | 0.613 |
| R-HSA-68877 | Mitotic Prometaphase | 2.452990e-01 | 0.610 |
| R-HSA-72086 | mRNA Capping | 2.463774e-01 | 0.608 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.463774e-01 | 0.608 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.463774e-01 | 0.608 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.463774e-01 | 0.608 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.463774e-01 | 0.608 |
| R-HSA-420092 | Glucagon-type ligand receptors | 2.463774e-01 | 0.608 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.463774e-01 | 0.608 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.467509e-01 | 0.608 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.474469e-01 | 0.607 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.497283e-01 | 0.603 |
| R-HSA-69239 | Synthesis of DNA | 2.497283e-01 | 0.603 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.517517e-01 | 0.599 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.524229e-01 | 0.598 |
| R-HSA-2424491 | DAP12 signaling | 2.524503e-01 | 0.598 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.524503e-01 | 0.598 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.524503e-01 | 0.598 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.524503e-01 | 0.598 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.527070e-01 | 0.597 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.527070e-01 | 0.597 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.527070e-01 | 0.597 |
| R-HSA-8953854 | Metabolism of RNA | 2.554075e-01 | 0.593 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.556866e-01 | 0.592 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.556866e-01 | 0.592 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.584746e-01 | 0.588 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.584746e-01 | 0.588 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.584746e-01 | 0.588 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.584746e-01 | 0.588 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.584746e-01 | 0.588 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.586670e-01 | 0.587 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.586670e-01 | 0.587 |
| R-HSA-202403 | TCR signaling | 2.586670e-01 | 0.587 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 2.587544e-01 | 0.587 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.644507e-01 | 0.578 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.644507e-01 | 0.578 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.646292e-01 | 0.577 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.646292e-01 | 0.577 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.669025e-01 | 0.574 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 2.669025e-01 | 0.574 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.676106e-01 | 0.572 |
| R-HSA-397795 | G-protein beta:gamma signalling | 2.703790e-01 | 0.568 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.703790e-01 | 0.568 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.703790e-01 | 0.568 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.703790e-01 | 0.568 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.703790e-01 | 0.568 |
| R-HSA-72172 | mRNA Splicing | 2.712524e-01 | 0.567 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.762599e-01 | 0.559 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.762599e-01 | 0.559 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.762599e-01 | 0.559 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.762599e-01 | 0.559 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.765540e-01 | 0.558 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.795342e-01 | 0.554 |
| R-HSA-597592 | Post-translational protein modification | 2.803258e-01 | 0.552 |
| R-HSA-392518 | Signal amplification | 2.820938e-01 | 0.550 |
| R-HSA-2142845 | Hyaluronan metabolism | 2.820938e-01 | 0.550 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.820938e-01 | 0.550 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.820938e-01 | 0.550 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.820938e-01 | 0.550 |
| R-HSA-5205647 | Mitophagy | 2.820938e-01 | 0.550 |
| R-HSA-373760 | L1CAM interactions | 2.825136e-01 | 0.549 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 2.878810e-01 | 0.541 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.887262e-01 | 0.540 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.909175e-01 | 0.536 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.914454e-01 | 0.535 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.914454e-01 | 0.535 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.936219e-01 | 0.532 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.936219e-01 | 0.532 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.936219e-01 | 0.532 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.936219e-01 | 0.532 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 2.936219e-01 | 0.532 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.003639e-01 | 0.522 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.003639e-01 | 0.522 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.006204e-01 | 0.522 |
| R-HSA-418990 | Adherens junctions interactions | 3.018910e-01 | 0.520 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.033330e-01 | 0.518 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.049663e-01 | 0.516 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.049663e-01 | 0.516 |
| R-HSA-8951664 | Neddylation | 3.084862e-01 | 0.511 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.105705e-01 | 0.508 |
| R-HSA-9648002 | RAS processing | 3.105705e-01 | 0.508 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.105705e-01 | 0.508 |
| R-HSA-392499 | Metabolism of proteins | 3.143781e-01 | 0.503 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.161298e-01 | 0.500 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.161298e-01 | 0.500 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.161298e-01 | 0.500 |
| R-HSA-114608 | Platelet degranulation | 3.181435e-01 | 0.497 |
| R-HSA-69481 | G2/M Checkpoints | 3.181435e-01 | 0.497 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.216447e-01 | 0.493 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.216447e-01 | 0.493 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.216447e-01 | 0.493 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.216447e-01 | 0.493 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.271155e-01 | 0.485 |
| R-HSA-167161 | HIV Transcription Initiation | 3.271155e-01 | 0.485 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.271155e-01 | 0.485 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.271155e-01 | 0.485 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.325424e-01 | 0.478 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.325424e-01 | 0.478 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.325424e-01 | 0.478 |
| R-HSA-73928 | Depyrimidination | 3.325424e-01 | 0.478 |
| R-HSA-165159 | MTOR signalling | 3.325424e-01 | 0.478 |
| R-HSA-9909396 | Circadian clock | 3.358194e-01 | 0.474 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.379260e-01 | 0.471 |
| R-HSA-9710421 | Defective pyroptosis | 3.379260e-01 | 0.471 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.387532e-01 | 0.470 |
| R-HSA-6798695 | Neutrophil degranulation | 3.431890e-01 | 0.464 |
| R-HSA-2172127 | DAP12 interactions | 3.432664e-01 | 0.464 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.432664e-01 | 0.464 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.485641e-01 | 0.458 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.485641e-01 | 0.458 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.538194e-01 | 0.451 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.538194e-01 | 0.451 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.538194e-01 | 0.451 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.538194e-01 | 0.451 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.538194e-01 | 0.451 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.538194e-01 | 0.451 |
| R-HSA-75153 | Apoptotic execution phase | 3.538194e-01 | 0.451 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 3.538194e-01 | 0.451 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.538194e-01 | 0.451 |
| R-HSA-437239 | Recycling pathway of L1 | 3.590326e-01 | 0.445 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.590326e-01 | 0.445 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.590326e-01 | 0.445 |
| R-HSA-9634597 | GPER1 signaling | 3.642040e-01 | 0.439 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.656765e-01 | 0.437 |
| R-HSA-73894 | DNA Repair | 3.681152e-01 | 0.434 |
| R-HSA-73893 | DNA Damage Bypass | 3.693341e-01 | 0.433 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 3.693341e-01 | 0.433 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.736025e-01 | 0.428 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.744231e-01 | 0.427 |
| R-HSA-421270 | Cell-cell junction organization | 3.744344e-01 | 0.427 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.764980e-01 | 0.424 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 3.794713e-01 | 0.421 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 3.794713e-01 | 0.421 |
| R-HSA-2514856 | The phototransduction cascade | 3.794713e-01 | 0.421 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.844791e-01 | 0.415 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.844791e-01 | 0.415 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.844791e-01 | 0.415 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.850890e-01 | 0.414 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.879416e-01 | 0.411 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.936294e-01 | 0.405 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.943748e-01 | 0.404 |
| R-HSA-418597 | G alpha (z) signalling events | 3.992632e-01 | 0.399 |
| R-HSA-9753281 | Paracetamol ADME | 3.992632e-01 | 0.399 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.005584e-01 | 0.397 |
| R-HSA-69306 | DNA Replication | 4.021167e-01 | 0.396 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.041125e-01 | 0.393 |
| R-HSA-75893 | TNF signaling | 4.041125e-01 | 0.393 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.041125e-01 | 0.393 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.136948e-01 | 0.383 |
| R-HSA-9711097 | Cellular response to starvation | 4.161377e-01 | 0.381 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.161377e-01 | 0.381 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.184285e-01 | 0.378 |
| R-HSA-382551 | Transport of small molecules | 4.202570e-01 | 0.376 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.217007e-01 | 0.375 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.231243e-01 | 0.374 |
| R-HSA-156590 | Glutathione conjugation | 4.231243e-01 | 0.374 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.242453e-01 | 0.372 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.277824e-01 | 0.369 |
| R-HSA-450294 | MAP kinase activation | 4.277824e-01 | 0.369 |
| R-HSA-8956321 | Nucleotide salvage | 4.277824e-01 | 0.369 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.324032e-01 | 0.364 |
| R-HSA-446728 | Cell junction organization | 4.327831e-01 | 0.364 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.369869e-01 | 0.360 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.369869e-01 | 0.360 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.369869e-01 | 0.360 |
| R-HSA-8848021 | Signaling by PTK6 | 4.369869e-01 | 0.360 |
| R-HSA-9658195 | Leishmania infection | 4.391570e-01 | 0.357 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.391570e-01 | 0.357 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.412758e-01 | 0.355 |
| R-HSA-1643685 | Disease | 4.482815e-01 | 0.348 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.505190e-01 | 0.346 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.505190e-01 | 0.346 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.518026e-01 | 0.345 |
| R-HSA-199991 | Membrane Trafficking | 4.554766e-01 | 0.342 |
| R-HSA-5218859 | Regulated Necrosis | 4.593606e-01 | 0.338 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.680609e-01 | 0.330 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.680609e-01 | 0.330 |
| R-HSA-448424 | Interleukin-17 signaling | 4.680609e-01 | 0.330 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.680609e-01 | 0.330 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.680609e-01 | 0.330 |
| R-HSA-1483257 | Phospholipid metabolism | 4.685325e-01 | 0.329 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.723589e-01 | 0.326 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.723589e-01 | 0.326 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.723589e-01 | 0.326 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.766224e-01 | 0.322 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.808516e-01 | 0.318 |
| R-HSA-4086398 | Ca2+ pathway | 4.808516e-01 | 0.318 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.808516e-01 | 0.318 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.850470e-01 | 0.314 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.892088e-01 | 0.311 |
| R-HSA-380287 | Centrosome maturation | 4.892088e-01 | 0.311 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.892088e-01 | 0.311 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.933371e-01 | 0.307 |
| R-HSA-1280218 | Adaptive Immune System | 4.953735e-01 | 0.305 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.974323e-01 | 0.303 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.990957e-01 | 0.302 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.014947e-01 | 0.300 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.014947e-01 | 0.300 |
| R-HSA-5617833 | Cilium Assembly | 5.041901e-01 | 0.297 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 5.055245e-01 | 0.296 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.067248e-01 | 0.295 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.095220e-01 | 0.293 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.095220e-01 | 0.293 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.095220e-01 | 0.293 |
| R-HSA-1500931 | Cell-Cell communication | 5.112765e-01 | 0.291 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.174210e-01 | 0.286 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.251276e-01 | 0.280 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.251938e-01 | 0.280 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.251938e-01 | 0.280 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.270570e-01 | 0.278 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.290334e-01 | 0.277 |
| R-HSA-168249 | Innate Immune System | 5.327127e-01 | 0.274 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.328423e-01 | 0.273 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.340510e-01 | 0.272 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.366206e-01 | 0.270 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.440864e-01 | 0.264 |
| R-HSA-9663891 | Selective autophagy | 5.440864e-01 | 0.264 |
| R-HSA-73884 | Base Excision Repair | 5.514328e-01 | 0.259 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.514328e-01 | 0.259 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.550619e-01 | 0.256 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.550619e-01 | 0.256 |
| R-HSA-112316 | Neuronal System | 5.591435e-01 | 0.252 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.622328e-01 | 0.250 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.622328e-01 | 0.250 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.727747e-01 | 0.242 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.796623e-01 | 0.237 |
| R-HSA-157579 | Telomere Maintenance | 5.830647e-01 | 0.234 |
| R-HSA-422356 | Regulation of insulin secretion | 5.864397e-01 | 0.232 |
| R-HSA-190236 | Signaling by FGFR | 5.864397e-01 | 0.232 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.922507e-01 | 0.227 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.964030e-01 | 0.224 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.996709e-01 | 0.222 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.996709e-01 | 0.222 |
| R-HSA-449147 | Signaling by Interleukins | 6.005938e-01 | 0.221 |
| R-HSA-72312 | rRNA processing | 6.053961e-01 | 0.218 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.061280e-01 | 0.217 |
| R-HSA-111885 | Opioid Signalling | 6.061280e-01 | 0.217 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.061280e-01 | 0.217 |
| R-HSA-9833110 | RSV-host interactions | 6.093178e-01 | 0.215 |
| R-HSA-418346 | Platelet homeostasis | 6.156205e-01 | 0.211 |
| R-HSA-211000 | Gene Silencing by RNA | 6.187340e-01 | 0.208 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.187340e-01 | 0.208 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.187340e-01 | 0.208 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 6.203281e-01 | 0.207 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.339297e-01 | 0.198 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.360524e-01 | 0.197 |
| R-HSA-913531 | Interferon Signaling | 6.360524e-01 | 0.197 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.368959e-01 | 0.196 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.398383e-01 | 0.194 |
| R-HSA-9609646 | HCMV Infection | 6.429159e-01 | 0.192 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.570023e-01 | 0.182 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 6.588442e-01 | 0.181 |
| R-HSA-68875 | Mitotic Prophase | 6.625413e-01 | 0.179 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.645386e-01 | 0.177 |
| R-HSA-3371556 | Cellular response to heat stress | 6.652774e-01 | 0.177 |
| R-HSA-73886 | Chromosome Maintenance | 6.652774e-01 | 0.177 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.733543e-01 | 0.172 |
| R-HSA-162582 | Signal Transduction | 6.754113e-01 | 0.170 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.989061e-01 | 0.156 |
| R-HSA-163685 | Integration of energy metabolism | 7.109278e-01 | 0.148 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.132744e-01 | 0.147 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.291795e-01 | 0.137 |
| R-HSA-2187338 | Visual phototransduction | 7.378717e-01 | 0.132 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.483487e-01 | 0.126 |
| R-HSA-73887 | Death Receptor Signaling | 7.524221e-01 | 0.124 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.524221e-01 | 0.124 |
| R-HSA-168256 | Immune System | 7.558731e-01 | 0.122 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.568688e-01 | 0.121 |
| R-HSA-9610379 | HCMV Late Events | 7.584100e-01 | 0.120 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.626358e-01 | 0.118 |
| R-HSA-5619102 | SLC transporter disorders | 7.773504e-01 | 0.109 |
| R-HSA-72306 | tRNA processing | 7.845071e-01 | 0.105 |
| R-HSA-418555 | G alpha (s) signalling events | 7.862604e-01 | 0.104 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.897245e-01 | 0.103 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.897245e-01 | 0.103 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.931328e-01 | 0.101 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.011464e-01 | 0.096 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.214432e-01 | 0.085 |
| R-HSA-9609690 | HCMV Early Events | 8.257724e-01 | 0.083 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.313831e-01 | 0.080 |
| R-HSA-6805567 | Keratinization | 8.407737e-01 | 0.075 |
| R-HSA-9748784 | Drug ADME | 8.556799e-01 | 0.068 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.670376e-01 | 0.062 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.681233e-01 | 0.061 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.734217e-01 | 0.059 |
| R-HSA-15869 | Metabolism of nucleotides | 8.754813e-01 | 0.058 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.755310e-01 | 0.058 |
| R-HSA-4839726 | Chromatin organization | 8.880819e-01 | 0.052 |
| R-HSA-109582 | Hemostasis | 8.941528e-01 | 0.049 |
| R-HSA-416476 | G alpha (q) signalling events | 9.010558e-01 | 0.045 |
| R-HSA-211859 | Biological oxidations | 9.363705e-01 | 0.029 |
| R-HSA-418594 | G alpha (i) signalling events | 9.698631e-01 | 0.013 |
| R-HSA-5668914 | Diseases of metabolism | 9.744720e-01 | 0.011 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.797723e-01 | 0.009 |
| R-HSA-500792 | GPCR ligand binding | 9.933971e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.986148e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.993168e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997101e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.998035e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999744e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.847 | 0.030 | 1 | 0.803 |
MOS |
0.843 | 0.299 | 1 | 0.889 |
ALK4 |
0.842 | 0.164 | -2 | 0.855 |
PDHK3_TYR |
0.839 | 0.271 | 4 | 0.901 |
TGFBR1 |
0.839 | 0.222 | -2 | 0.835 |
DAPK2 |
0.838 | 0.140 | -3 | 0.862 |
VRK2 |
0.837 | -0.190 | 1 | 0.835 |
ALK2 |
0.837 | 0.181 | -2 | 0.849 |
PASK |
0.837 | 0.183 | -3 | 0.859 |
EPHA6 |
0.836 | 0.226 | -1 | 0.842 |
BMPR1B |
0.835 | 0.246 | 1 | 0.823 |
PKR |
0.835 | -0.029 | 1 | 0.771 |
CAMLCK |
0.834 | 0.106 | -2 | 0.837 |
MAP2K6_TYR |
0.833 | 0.161 | -1 | 0.830 |
TAK1 |
0.833 | -0.098 | 1 | 0.747 |
BMPR2 |
0.833 | -0.092 | -2 | 0.878 |
MAP2K4_TYR |
0.832 | 0.118 | -1 | 0.822 |
BMPR2_TYR |
0.832 | 0.125 | -1 | 0.834 |
MEK1 |
0.831 | -0.137 | 2 | 0.830 |
NIK |
0.831 | 0.002 | -3 | 0.856 |
PDHK1_TYR |
0.831 | 0.125 | -1 | 0.854 |
PDHK4_TYR |
0.830 | 0.115 | 2 | 0.893 |
CDKL1 |
0.830 | 0.220 | -3 | 0.836 |
PRPK |
0.830 | -0.021 | -1 | 0.812 |
JNK2 |
0.830 | 0.250 | 1 | 0.740 |
BRAF |
0.830 | -0.070 | -4 | 0.793 |
CAMK1B |
0.830 | 0.126 | -3 | 0.863 |
ALPHAK3 |
0.830 | 0.004 | -1 | 0.751 |
ICK |
0.829 | 0.232 | -3 | 0.857 |
PRP4 |
0.828 | 0.188 | -3 | 0.748 |
NLK |
0.828 | 0.184 | 1 | 0.871 |
JNK3 |
0.828 | 0.229 | 1 | 0.778 |
ACVR2B |
0.828 | 0.147 | -2 | 0.824 |
GCK |
0.828 | -0.045 | 1 | 0.743 |
EPHB4 |
0.828 | 0.138 | -1 | 0.819 |
P38B |
0.827 | 0.249 | 1 | 0.766 |
DAPK3 |
0.827 | 0.153 | -3 | 0.824 |
LRRK2 |
0.827 | -0.152 | 2 | 0.829 |
LATS1 |
0.827 | 0.110 | -3 | 0.852 |
PDK1 |
0.827 | -0.047 | 1 | 0.749 |
GRK7 |
0.826 | 0.213 | 1 | 0.842 |
TTK |
0.826 | -0.002 | -2 | 0.826 |
MAP2K7_TYR |
0.826 | -0.079 | 2 | 0.881 |
EEF2K |
0.825 | -0.036 | 3 | 0.777 |
P38A |
0.825 | 0.225 | 1 | 0.797 |
EPHA4 |
0.825 | 0.122 | 2 | 0.840 |
TESK1_TYR |
0.825 | -0.011 | 3 | 0.850 |
BMPR1A |
0.825 | 0.195 | 1 | 0.807 |
MEK5 |
0.825 | -0.217 | 2 | 0.813 |
TXK |
0.824 | 0.176 | 1 | 0.853 |
HIPK1 |
0.824 | 0.315 | 1 | 0.803 |
ASK1 |
0.824 | -0.169 | 1 | 0.704 |
DLK |
0.824 | -0.129 | 1 | 0.801 |
PKMYT1_TYR |
0.824 | -0.015 | 3 | 0.833 |
VRK1 |
0.823 | -0.229 | 2 | 0.778 |
TAO2 |
0.823 | -0.095 | 2 | 0.806 |
CLK3 |
0.823 | 0.333 | 1 | 0.879 |
MEKK2 |
0.823 | -0.127 | 2 | 0.772 |
ATR |
0.823 | -0.005 | 1 | 0.783 |
ABL2 |
0.823 | 0.124 | -1 | 0.810 |
ACVR2A |
0.823 | 0.102 | -2 | 0.803 |
TAO3 |
0.823 | -0.049 | 1 | 0.752 |
SKMLCK |
0.822 | 0.137 | -2 | 0.849 |
DAPK1 |
0.822 | 0.163 | -3 | 0.813 |
SRMS |
0.822 | 0.112 | 1 | 0.856 |
FGFR2 |
0.822 | 0.094 | 3 | 0.816 |
DYRK2 |
0.821 | 0.312 | 1 | 0.800 |
PINK1_TYR |
0.821 | -0.069 | 1 | 0.823 |
BLK |
0.821 | 0.186 | -1 | 0.860 |
ANKRD3 |
0.821 | -0.137 | 1 | 0.790 |
TNIK |
0.821 | -0.077 | 3 | 0.814 |
GRK6 |
0.821 | 0.092 | 1 | 0.863 |
LKB1 |
0.820 | -0.116 | -3 | 0.776 |
SMMLCK |
0.820 | 0.079 | -3 | 0.830 |
YES1 |
0.820 | 0.065 | -1 | 0.839 |
RET |
0.820 | -0.016 | 1 | 0.765 |
HPK1 |
0.820 | -0.044 | 1 | 0.723 |
FER |
0.820 | 0.031 | 1 | 0.871 |
MST3 |
0.819 | -0.022 | 2 | 0.787 |
DMPK1 |
0.819 | 0.150 | -3 | 0.790 |
CAMKK2 |
0.819 | -0.150 | -2 | 0.760 |
MINK |
0.819 | -0.144 | 1 | 0.705 |
ABL1 |
0.819 | 0.089 | -1 | 0.800 |
MST2 |
0.818 | -0.171 | 1 | 0.750 |
OSR1 |
0.818 | -0.078 | 2 | 0.768 |
CAMKK1 |
0.818 | -0.176 | -2 | 0.765 |
CAMK2G |
0.818 | 0.058 | 2 | 0.858 |
FGR |
0.818 | 0.038 | 1 | 0.825 |
MAP3K15 |
0.818 | -0.165 | 1 | 0.708 |
CSF1R |
0.818 | 0.026 | 3 | 0.791 |
LCK |
0.818 | 0.129 | -1 | 0.850 |
MEKK3 |
0.818 | -0.118 | 1 | 0.749 |
MST1R |
0.817 | -0.015 | 3 | 0.814 |
P38G |
0.817 | 0.239 | 1 | 0.696 |
ERK5 |
0.817 | 0.119 | 1 | 0.843 |
MERTK |
0.817 | 0.085 | 3 | 0.788 |
MAK |
0.817 | 0.305 | -2 | 0.751 |
EPHB2 |
0.817 | 0.083 | -1 | 0.813 |
INSRR |
0.817 | 0.020 | 3 | 0.748 |
MET |
0.817 | 0.090 | 3 | 0.801 |
NEK5 |
0.816 | -0.201 | 1 | 0.744 |
LIMK2_TYR |
0.816 | -0.008 | -3 | 0.847 |
FYN |
0.816 | 0.137 | -1 | 0.830 |
EPHB3 |
0.816 | 0.055 | -1 | 0.809 |
KHS1 |
0.815 | -0.079 | 1 | 0.705 |
PBK |
0.815 | -0.018 | 1 | 0.716 |
HCK |
0.815 | 0.044 | -1 | 0.839 |
KHS2 |
0.815 | -0.027 | 1 | 0.721 |
EPHB1 |
0.815 | 0.031 | 1 | 0.835 |
MST1 |
0.815 | -0.210 | 1 | 0.726 |
MEKK6 |
0.815 | -0.142 | 1 | 0.725 |
NEK1 |
0.815 | -0.231 | 1 | 0.716 |
CDC7 |
0.815 | 0.149 | 1 | 0.862 |
NEK8 |
0.815 | -0.173 | 2 | 0.790 |
EPHA7 |
0.815 | 0.087 | 2 | 0.843 |
TYRO3 |
0.814 | -0.053 | 3 | 0.781 |
NEK11 |
0.814 | -0.198 | 1 | 0.738 |
PIM3 |
0.814 | 0.186 | -3 | 0.856 |
BIKE |
0.814 | -0.047 | 1 | 0.680 |
PLK1 |
0.814 | -0.007 | -2 | 0.808 |
CDKL5 |
0.814 | 0.228 | -3 | 0.832 |
PTK2B |
0.814 | 0.121 | -1 | 0.769 |
JAK3 |
0.814 | -0.004 | 1 | 0.753 |
MEKK1 |
0.814 | -0.190 | 1 | 0.736 |
DDR1 |
0.814 | -0.070 | 4 | 0.855 |
KIT |
0.814 | 0.008 | 3 | 0.795 |
RAF1 |
0.814 | -0.076 | 1 | 0.790 |
MPSK1 |
0.814 | -0.004 | 1 | 0.712 |
GRK5 |
0.814 | -0.030 | -3 | 0.798 |
FGFR3 |
0.814 | 0.064 | 3 | 0.790 |
KDR |
0.814 | 0.044 | 3 | 0.775 |
DYRK1A |
0.813 | 0.285 | 1 | 0.812 |
YSK4 |
0.813 | -0.152 | 1 | 0.716 |
GRK1 |
0.813 | 0.225 | -2 | 0.878 |
HGK |
0.813 | -0.143 | 3 | 0.817 |
COT |
0.813 | 0.106 | 2 | 0.817 |
EPHA8 |
0.812 | 0.126 | -1 | 0.815 |
TNK2 |
0.812 | 0.039 | 3 | 0.783 |
DYRK4 |
0.812 | 0.323 | 1 | 0.750 |
P38D |
0.812 | 0.239 | 1 | 0.680 |
ROCK2 |
0.812 | 0.110 | -3 | 0.803 |
ITK |
0.812 | 0.017 | -1 | 0.794 |
HIPK3 |
0.811 | 0.275 | 1 | 0.785 |
EPHA5 |
0.811 | 0.104 | 2 | 0.843 |
ROS1 |
0.811 | -0.072 | 3 | 0.750 |
PTK2 |
0.811 | 0.154 | -1 | 0.778 |
ERBB2 |
0.811 | 0.043 | 1 | 0.803 |
FLT1 |
0.811 | 0.048 | -1 | 0.823 |
EGFR |
0.811 | 0.115 | 1 | 0.748 |
SYK |
0.811 | 0.184 | -1 | 0.790 |
FGFR1 |
0.811 | -0.005 | 3 | 0.778 |
FRK |
0.810 | 0.094 | -1 | 0.848 |
EPHA3 |
0.810 | 0.016 | 2 | 0.838 |
MEK2 |
0.810 | -0.284 | 2 | 0.791 |
JNK1 |
0.810 | 0.191 | 1 | 0.760 |
GRK2 |
0.810 | 0.046 | -2 | 0.776 |
JAK2 |
0.809 | -0.134 | 1 | 0.750 |
PIM1 |
0.809 | 0.174 | -3 | 0.812 |
PERK |
0.809 | -0.110 | -2 | 0.842 |
ZAK |
0.809 | -0.189 | 1 | 0.724 |
TEK |
0.808 | -0.024 | 3 | 0.731 |
SRPK3 |
0.808 | 0.240 | -3 | 0.780 |
ERK2 |
0.808 | 0.162 | 1 | 0.774 |
TLK2 |
0.808 | -0.062 | 1 | 0.721 |
MOK |
0.808 | 0.272 | 1 | 0.795 |
LIMK1_TYR |
0.808 | -0.201 | 2 | 0.844 |
FLT3 |
0.808 | -0.032 | 3 | 0.785 |
CDK1 |
0.808 | 0.219 | 1 | 0.772 |
BMX |
0.808 | 0.012 | -1 | 0.730 |
MYO3A |
0.808 | -0.146 | 1 | 0.698 |
DYRK1B |
0.808 | 0.273 | 1 | 0.767 |
AXL |
0.808 | -0.012 | 3 | 0.788 |
HIPK4 |
0.808 | 0.274 | 1 | 0.815 |
TYK2 |
0.807 | -0.213 | 1 | 0.753 |
LTK |
0.807 | -0.005 | 3 | 0.753 |
MYO3B |
0.807 | -0.116 | 2 | 0.776 |
MASTL |
0.807 | -0.215 | -2 | 0.816 |
ERK1 |
0.807 | 0.213 | 1 | 0.741 |
HIPK2 |
0.807 | 0.327 | 1 | 0.726 |
CLK4 |
0.807 | 0.247 | -3 | 0.807 |
PIM2 |
0.807 | 0.180 | -3 | 0.788 |
EPHA1 |
0.806 | 0.047 | 3 | 0.786 |
PLK3 |
0.806 | 0.015 | 2 | 0.830 |
PDHK4 |
0.806 | -0.258 | 1 | 0.823 |
P70S6KB |
0.806 | 0.150 | -3 | 0.820 |
NEK4 |
0.806 | -0.237 | 1 | 0.695 |
STLK3 |
0.806 | -0.253 | 1 | 0.685 |
TEC |
0.806 | -0.001 | -1 | 0.725 |
PDGFRB |
0.806 | -0.087 | 3 | 0.797 |
MLK2 |
0.806 | -0.177 | 2 | 0.787 |
DYRK3 |
0.806 | 0.272 | 1 | 0.795 |
PKN3 |
0.805 | 0.059 | -3 | 0.836 |
YSK1 |
0.805 | -0.163 | 2 | 0.758 |
DSTYK |
0.805 | 0.020 | 2 | 0.844 |
TLK1 |
0.805 | -0.063 | -2 | 0.854 |
DRAK1 |
0.805 | 0.024 | 1 | 0.775 |
MLK1 |
0.804 | -0.114 | 2 | 0.769 |
ERBB4 |
0.804 | 0.148 | 1 | 0.783 |
SRPK1 |
0.804 | 0.266 | -3 | 0.811 |
ALK |
0.804 | -0.038 | 3 | 0.728 |
SRC |
0.804 | 0.052 | -1 | 0.826 |
DCAMKL1 |
0.804 | 0.077 | -3 | 0.813 |
EPHA2 |
0.804 | 0.095 | -1 | 0.780 |
MATK |
0.803 | 0.005 | -1 | 0.733 |
GSK3A |
0.803 | 0.152 | 4 | 0.531 |
CDK14 |
0.803 | 0.235 | 1 | 0.763 |
FGFR4 |
0.803 | 0.037 | -1 | 0.773 |
LOK |
0.803 | -0.097 | -2 | 0.780 |
FLT4 |
0.802 | -0.051 | 3 | 0.757 |
NTRK1 |
0.802 | -0.102 | -1 | 0.777 |
RSK2 |
0.802 | 0.214 | -3 | 0.821 |
CLK2 |
0.802 | 0.346 | -3 | 0.808 |
LYN |
0.802 | -0.003 | 3 | 0.718 |
CSK |
0.802 | -0.005 | 2 | 0.843 |
HUNK |
0.801 | -0.066 | 2 | 0.838 |
MTOR |
0.801 | -0.025 | 1 | 0.805 |
CHAK2 |
0.801 | -0.091 | -1 | 0.741 |
CDK5 |
0.801 | 0.177 | 1 | 0.794 |
WNK1 |
0.800 | -0.039 | -2 | 0.844 |
CRIK |
0.800 | 0.171 | -3 | 0.755 |
DNAPK |
0.800 | 0.011 | 1 | 0.648 |
ATM |
0.800 | 0.002 | 1 | 0.721 |
GSK3B |
0.800 | 0.083 | 4 | 0.524 |
MLK4 |
0.799 | -0.035 | 2 | 0.729 |
PDHK1 |
0.799 | -0.274 | 1 | 0.793 |
RIPK1 |
0.799 | -0.183 | 1 | 0.736 |
HRI |
0.799 | -0.215 | -2 | 0.841 |
TSSK2 |
0.799 | -0.044 | -5 | 0.747 |
DDR2 |
0.799 | 0.020 | 3 | 0.759 |
NTRK3 |
0.798 | -0.054 | -1 | 0.741 |
RIPK3 |
0.798 | -0.083 | 3 | 0.754 |
PLK2 |
0.798 | 0.079 | -3 | 0.771 |
AMPKA1 |
0.798 | 0.013 | -3 | 0.849 |
GRK4 |
0.798 | 0.012 | -2 | 0.871 |
MYLK4 |
0.798 | 0.089 | -2 | 0.762 |
PDGFRA |
0.798 | -0.149 | 3 | 0.796 |
BTK |
0.798 | -0.149 | -1 | 0.739 |
AKT2 |
0.797 | 0.177 | -3 | 0.751 |
AAK1 |
0.797 | -0.022 | 1 | 0.580 |
CDK17 |
0.797 | 0.221 | 1 | 0.705 |
NUAK2 |
0.797 | 0.051 | -3 | 0.851 |
WNK4 |
0.797 | -0.140 | -2 | 0.832 |
CAMK2B |
0.797 | 0.132 | 2 | 0.823 |
NEK9 |
0.797 | -0.241 | 2 | 0.789 |
ROCK1 |
0.797 | 0.094 | -3 | 0.775 |
PTK6 |
0.797 | -0.144 | -1 | 0.720 |
DCAMKL2 |
0.796 | 0.026 | -3 | 0.828 |
MRCKA |
0.796 | 0.093 | -3 | 0.773 |
P90RSK |
0.796 | 0.162 | -3 | 0.825 |
INSR |
0.796 | -0.105 | 3 | 0.718 |
TGFBR2 |
0.795 | -0.005 | -2 | 0.819 |
PINK1 |
0.795 | -0.112 | 1 | 0.796 |
RSK4 |
0.795 | 0.214 | -3 | 0.798 |
ERK7 |
0.795 | 0.077 | 2 | 0.529 |
JAK1 |
0.795 | -0.103 | 1 | 0.690 |
SGK3 |
0.795 | 0.119 | -3 | 0.786 |
SLK |
0.795 | -0.108 | -2 | 0.755 |
MLK3 |
0.795 | -0.064 | 2 | 0.712 |
CAMK2A |
0.794 | 0.155 | 2 | 0.846 |
CDK18 |
0.794 | 0.241 | 1 | 0.732 |
PAK1 |
0.794 | 0.064 | -2 | 0.772 |
CLK1 |
0.794 | 0.249 | -3 | 0.789 |
TBK1 |
0.794 | -0.112 | 1 | 0.678 |
CAMK2D |
0.794 | 0.017 | -3 | 0.830 |
WEE1_TYR |
0.794 | -0.100 | -1 | 0.689 |
PKCD |
0.794 | 0.005 | 2 | 0.756 |
PKN2 |
0.793 | 0.017 | -3 | 0.828 |
NTRK2 |
0.793 | -0.155 | 3 | 0.764 |
CDK2 |
0.793 | 0.103 | 1 | 0.854 |
MRCKB |
0.793 | 0.105 | -3 | 0.769 |
CDK16 |
0.793 | 0.232 | 1 | 0.719 |
ZAP70 |
0.793 | 0.144 | -1 | 0.704 |
TNK1 |
0.793 | -0.135 | 3 | 0.764 |
PAK2 |
0.793 | 0.004 | -2 | 0.762 |
CDK4 |
0.793 | 0.192 | 1 | 0.733 |
TAO1 |
0.792 | -0.145 | 1 | 0.653 |
TTBK2 |
0.792 | -0.082 | 2 | 0.733 |
MSK1 |
0.792 | 0.162 | -3 | 0.785 |
SGK1 |
0.792 | 0.180 | -3 | 0.680 |
TNNI3K_TYR |
0.792 | -0.085 | 1 | 0.738 |
NEK10_TYR |
0.791 | -0.162 | 1 | 0.616 |
MST4 |
0.791 | -0.034 | 2 | 0.790 |
MARK4 |
0.791 | -0.056 | 4 | 0.823 |
IKKB |
0.791 | -0.042 | -2 | 0.776 |
NEK2 |
0.790 | -0.187 | 2 | 0.772 |
CHK1 |
0.790 | -0.070 | -3 | 0.818 |
CK2A2 |
0.790 | 0.190 | 1 | 0.794 |
CDK13 |
0.790 | 0.164 | 1 | 0.760 |
CDK6 |
0.790 | 0.166 | 1 | 0.734 |
NEK7 |
0.790 | -0.177 | -3 | 0.775 |
ULK2 |
0.790 | -0.186 | 2 | 0.787 |
CDK8 |
0.790 | 0.179 | 1 | 0.763 |
CDK3 |
0.790 | 0.184 | 1 | 0.720 |
AURA |
0.790 | 0.092 | -2 | 0.620 |
IKKE |
0.790 | -0.115 | 1 | 0.673 |
CDK7 |
0.789 | 0.180 | 1 | 0.779 |
SMG1 |
0.789 | -0.088 | 1 | 0.721 |
NDR1 |
0.789 | 0.074 | -3 | 0.837 |
IGF1R |
0.789 | -0.064 | 3 | 0.665 |
GRK3 |
0.789 | 0.051 | -2 | 0.751 |
CDK12 |
0.788 | 0.173 | 1 | 0.738 |
RSK3 |
0.788 | 0.160 | -3 | 0.818 |
NEK6 |
0.788 | -0.068 | -2 | 0.845 |
CAMK4 |
0.787 | -0.026 | -3 | 0.813 |
NDR2 |
0.787 | 0.134 | -3 | 0.844 |
TSSK1 |
0.786 | -0.036 | -3 | 0.873 |
IRAK4 |
0.786 | -0.190 | 1 | 0.696 |
AMPKA2 |
0.786 | 0.025 | -3 | 0.829 |
WNK3 |
0.786 | -0.246 | 1 | 0.747 |
BUB1 |
0.786 | 0.017 | -5 | 0.699 |
CDK10 |
0.786 | 0.230 | 1 | 0.748 |
HASPIN |
0.786 | -0.062 | -1 | 0.601 |
SRPK2 |
0.785 | 0.245 | -3 | 0.744 |
PKACG |
0.785 | 0.090 | -2 | 0.744 |
PAK3 |
0.785 | 0.004 | -2 | 0.768 |
MSK2 |
0.785 | 0.119 | -3 | 0.783 |
MAPKAPK3 |
0.784 | 0.071 | -3 | 0.795 |
GCN2 |
0.784 | -0.087 | 2 | 0.826 |
FES |
0.784 | -0.021 | -1 | 0.699 |
CHAK1 |
0.784 | -0.207 | 2 | 0.765 |
IRE1 |
0.783 | -0.099 | 1 | 0.705 |
CK2A1 |
0.783 | 0.176 | 1 | 0.778 |
MUSK |
0.783 | -0.028 | 1 | 0.731 |
CAMK1D |
0.783 | 0.084 | -3 | 0.728 |
PRKD1 |
0.783 | 0.112 | -3 | 0.844 |
AURB |
0.783 | 0.059 | -2 | 0.646 |
CDK9 |
0.782 | 0.142 | 1 | 0.763 |
IKKA |
0.782 | -0.021 | -2 | 0.776 |
CHK2 |
0.782 | 0.098 | -3 | 0.698 |
IRE2 |
0.781 | -0.090 | 2 | 0.707 |
PKCA |
0.781 | 0.001 | 2 | 0.689 |
AKT1 |
0.781 | 0.127 | -3 | 0.757 |
LATS2 |
0.781 | 0.059 | -5 | 0.767 |
PKACB |
0.781 | 0.162 | -2 | 0.665 |
CAMK1G |
0.781 | 0.048 | -3 | 0.792 |
MAPKAPK2 |
0.780 | 0.171 | -3 | 0.768 |
PRKD3 |
0.780 | 0.093 | -3 | 0.792 |
NEK3 |
0.780 | -0.240 | 1 | 0.671 |
MELK |
0.780 | -0.014 | -3 | 0.816 |
NIM1 |
0.780 | -0.062 | 3 | 0.759 |
PLK4 |
0.780 | -0.103 | 2 | 0.713 |
KIS |
0.780 | 0.290 | 1 | 0.786 |
CDK19 |
0.779 | 0.192 | 1 | 0.731 |
PKCH |
0.778 | -0.038 | 2 | 0.684 |
PKCZ |
0.778 | -0.074 | 2 | 0.739 |
SBK |
0.778 | 0.162 | -3 | 0.651 |
IRAK1 |
0.777 | -0.298 | -1 | 0.688 |
PKG2 |
0.777 | 0.080 | -2 | 0.668 |
P70S6K |
0.777 | 0.120 | -3 | 0.747 |
CK1D |
0.777 | 0.017 | -3 | 0.446 |
PKCG |
0.776 | -0.013 | 2 | 0.705 |
MARK2 |
0.776 | -0.057 | 4 | 0.718 |
STK33 |
0.776 | -0.138 | 2 | 0.692 |
ULK1 |
0.776 | -0.205 | -3 | 0.746 |
PKCB |
0.775 | -0.009 | 2 | 0.685 |
PRKD2 |
0.775 | 0.137 | -3 | 0.807 |
AURC |
0.775 | 0.096 | -2 | 0.649 |
QIK |
0.774 | -0.119 | -3 | 0.819 |
QSK |
0.774 | -0.009 | 4 | 0.796 |
SSTK |
0.773 | -0.044 | 4 | 0.802 |
MNK1 |
0.773 | 0.009 | -2 | 0.786 |
MARK1 |
0.772 | -0.055 | 4 | 0.770 |
MARK3 |
0.772 | -0.019 | 4 | 0.748 |
YANK3 |
0.772 | -0.004 | 2 | 0.494 |
PKCE |
0.771 | 0.037 | 2 | 0.684 |
PKACA |
0.770 | 0.142 | -2 | 0.612 |
CK1A2 |
0.770 | -0.012 | -3 | 0.452 |
FAM20C |
0.769 | 0.075 | 2 | 0.625 |
BCKDK |
0.769 | -0.233 | -1 | 0.700 |
RIPK2 |
0.769 | -0.313 | 1 | 0.669 |
TTBK1 |
0.768 | -0.123 | 2 | 0.675 |
MNK2 |
0.768 | -0.018 | -2 | 0.766 |
SNRK |
0.768 | -0.091 | 2 | 0.745 |
BRSK1 |
0.767 | 0.050 | -3 | 0.813 |
CK1E |
0.767 | 0.007 | -3 | 0.505 |
AKT3 |
0.766 | 0.159 | -3 | 0.699 |
PKCI |
0.766 | -0.043 | 2 | 0.703 |
SIK |
0.766 | 0.017 | -3 | 0.783 |
CAMK1A |
0.765 | 0.066 | -3 | 0.711 |
PRKX |
0.765 | 0.197 | -3 | 0.729 |
PHKG1 |
0.765 | -0.021 | -3 | 0.828 |
PKCT |
0.764 | -0.036 | 2 | 0.693 |
MAPKAPK5 |
0.762 | 0.000 | -3 | 0.747 |
NUAK1 |
0.759 | -0.041 | -3 | 0.808 |
BRSK2 |
0.758 | -0.058 | -3 | 0.812 |
PAK6 |
0.758 | 0.021 | -2 | 0.682 |
YANK2 |
0.758 | -0.040 | 2 | 0.498 |
PKN1 |
0.753 | 0.037 | -3 | 0.761 |
PHKG2 |
0.748 | -0.025 | -3 | 0.808 |
PAK5 |
0.746 | -0.001 | -2 | 0.647 |
PAK4 |
0.739 | 0.006 | -2 | 0.645 |
CK1G1 |
0.731 | -0.081 | -3 | 0.495 |
PKG1 |
0.730 | 0.036 | -2 | 0.585 |
CK1G3 |
0.727 | -0.043 | -3 | 0.317 |
CK1G2 |
0.720 | 0.005 | -3 | 0.410 |
CK1A |
0.712 | -0.011 | -3 | 0.361 |