Motif 12 (n=92)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0M3HER8 | GOLGA6L10 | S444 | ochoa | Golgin A6 family like 10 | None |
| A6NEF3 | GOLGA6L4 | S482 | ochoa | Golgin subfamily A member 6-like protein 4 | None |
| A6NEM1 | GOLGA6L9 | S340 | ochoa | Golgin subfamily A member 6-like protein 9 | None |
| A6NI86 | GOLGA6L10 | S430 | ochoa | Golgin subfamily A member 6-like protein 10 | None |
| A8K979 | ERI2 | S478 | ochoa | ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) | None |
| H0YKK7 | GOLGA6L19 | S458 | ochoa | Putative golgin subfamily A member 6-like protein 19 | None |
| O14979 | HNRNPDL | S241 | ochoa | Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
| O43493 | TGOLN2 | S306 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O75330 | HMMR | S20 | ochoa | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) | Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}. |
| O75534 | CSDE1 | S445 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O75683 | SURF6 | S74 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O94888 | UBXN7 | S350 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O95613 | PCNT | S2900 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95831 | AIFM1 | S100 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P0DPH7 | TUBA3C | S287 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S287 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12036 | NEFH | S526 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S532 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S540 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S546 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S560 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S566 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S614 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S620 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S668 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S710 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S801 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P18031 | PTPN1 | S386 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18583 | SON | S1697 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P27816 | MAP4 | S329 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28715 | ERCC5 | S324 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P46821 | MAP1B | S601 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S614 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P52292 | KPNA2 | S483 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P68363 | TUBA1B | S287 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S287 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00059 | TFAM | T122 | ochoa | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q00059 | TFAM | S177 | psp | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q05519 | SRSF11 | S449 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q05682 | CALD1 | S724 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q08050 | FOXM1 | S451 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12802 | AKAP13 | S983 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S727 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12955 | ANK3 | S4298 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13523 | PRP4K | S328 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14103 | HNRNPD | S190 | ochoa | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q14966 | ZNF638 | S885 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15468 | STIL | S1225 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q5T1V6 | DDX59 | S160 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5TCZ1 | SH3PXD2A | S547 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VT06 | CEP350 | S1024 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUA4 | ZNF318 | S1243 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q641Q2 | WASHC2A | S939 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6JBY9 | RCSD1 | S68 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6PEY2 | TUBA3E | S287 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6VY07 | PACS1 | S495 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZMS4 | ZNF852 | S145 | ochoa | Zinc finger protein 852 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6ZRV2 | FAM83H | S1147 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZUM4 | ARHGAP27 | S486 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | S287 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z333 | SETX | S911 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q8IVF2 | AHNAK2 | S593 | ochoa | Protein AHNAK2 | None |
| Q8IVL0 | NAV3 | S1190 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IYB3 | SRRM1 | S260 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N4S0 | CCDC82 | S219 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8NEY1 | NAV1 | T727 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NF91 | SYNE1 | S8386 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NF99 | ZNF397 | S182 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8TF46 | DIS3L | S989 | ochoa | DIS3-like exonuclease 1 (EC 3.1.13.1) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389). {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389, ECO:0000269|PubMed:37602378}. |
| Q8WUM0 | NUP133 | S131 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q93073 | SECISBP2L | S934 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q96T88 | UHRF1 | S661 | psp | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99614 | TTC1 | S89 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q9BY89 | KIAA1671 | S1695 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H2B2 | SYT4 | S69 | ochoa | Synaptotagmin-4 (Synaptotagmin IV) (SytIV) | Synaptotagmin family member which does not bind Ca(2+) (By similarity) (PubMed:23999003). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}. |
| Q9H8Y5 | ANKZF1 | S361 | ochoa | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
| Q9NR30 | DDX21 | S71 | ochoa|psp | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR48 | ASH1L | S1544 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NR48 | ASH1L | S1953 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NY65 | TUBA8 | S287 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9P0L1 | ZKSCAN7 | S369 | ochoa | Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64) | May be involved in transcriptional regulation. |
| Q9P2R6 | RERE | S642 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UBU7 | DBF4 | S359 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UK61 | TASOR | S927 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKM9 | RALY | S176 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UPA5 | BSN | S1098 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPQ0 | LIMCH1 | S303 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y478 | PRKAB1 | S40 | ochoa | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y6D6 | ARFGEF1 | S52 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| R4GMW8 | BIVM-ERCC5 | S778 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q9HAW4 | CLSPN | S265 | EPSD|PSP | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| P12036 | NEFH | S518 | SIGNOR|iPTMNet | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.645051e-11 | 10.784 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.994693e-11 | 10.399 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.429746e-11 | 10.265 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 9.651269e-11 | 10.015 |
| R-HSA-9646399 | Aggrephagy | 2.075544e-10 | 9.683 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.385734e-10 | 9.470 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 7.054755e-10 | 9.152 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.426714e-09 | 8.846 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.045020e-09 | 8.689 |
| R-HSA-9663891 | Selective autophagy | 2.846768e-09 | 8.546 |
| R-HSA-190861 | Gap junction assembly | 2.877749e-09 | 8.541 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.604320e-09 | 8.584 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.050898e-08 | 7.978 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 9.687729e-09 | 8.014 |
| R-HSA-190828 | Gap junction trafficking | 1.449955e-08 | 7.839 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.397856e-08 | 7.855 |
| R-HSA-437239 | Recycling pathway of L1 | 2.120079e-08 | 7.674 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.633428e-08 | 7.579 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.699347e-08 | 7.569 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.302537e-08 | 7.276 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.523568e-08 | 7.258 |
| R-HSA-983189 | Kinesins | 8.860686e-08 | 7.053 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.076251e-07 | 6.968 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.160529e-07 | 6.935 |
| R-HSA-69275 | G2/M Transition | 1.466120e-07 | 6.834 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.601925e-07 | 6.795 |
| R-HSA-1632852 | Macroautophagy | 1.772680e-07 | 6.751 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.865906e-07 | 6.729 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.415842e-07 | 6.617 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.924325e-07 | 6.534 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.585925e-07 | 6.445 |
| R-HSA-9612973 | Autophagy | 3.945412e-07 | 6.404 |
| R-HSA-373760 | L1CAM interactions | 4.996624e-07 | 6.301 |
| R-HSA-9833482 | PKR-mediated signaling | 4.948936e-07 | 6.305 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.615625e-07 | 6.179 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.796839e-07 | 6.056 |
| R-HSA-391251 | Protein folding | 1.310997e-06 | 5.882 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.794314e-06 | 5.746 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.882268e-06 | 5.725 |
| R-HSA-68877 | Mitotic Prometaphase | 1.985805e-06 | 5.702 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.900025e-06 | 5.538 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.105193e-06 | 5.387 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.911919e-06 | 5.228 |
| R-HSA-1640170 | Cell Cycle | 6.064375e-06 | 5.217 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.915463e-06 | 5.050 |
| R-HSA-5620924 | Intraflagellar transport | 1.323741e-05 | 4.878 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.461278e-05 | 4.835 |
| R-HSA-5617833 | Cilium Assembly | 1.594071e-05 | 4.797 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.895608e-05 | 4.722 |
| R-HSA-9609690 | HCMV Early Events | 1.948836e-05 | 4.710 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.220450e-05 | 4.654 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.367755e-05 | 4.626 |
| R-HSA-68882 | Mitotic Anaphase | 3.756853e-05 | 4.425 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.869638e-05 | 4.412 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.080271e-05 | 4.216 |
| R-HSA-913531 | Interferon Signaling | 5.554010e-05 | 4.255 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.000173e-05 | 4.097 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.636759e-05 | 4.064 |
| R-HSA-9609646 | HCMV Infection | 9.544082e-05 | 4.020 |
| R-HSA-68886 | M Phase | 2.854354e-04 | 3.544 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.229771e-04 | 3.491 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.713203e-04 | 3.173 |
| R-HSA-199991 | Membrane Trafficking | 7.936287e-04 | 3.100 |
| R-HSA-112316 | Neuronal System | 1.128689e-03 | 2.947 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.431795e-03 | 2.844 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.407044e-03 | 2.619 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.239668e-03 | 2.373 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.468450e-03 | 2.189 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.468450e-03 | 2.189 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 9.250504e-03 | 2.034 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.250504e-03 | 2.034 |
| R-HSA-380287 | Centrosome maturation | 9.878390e-03 | 2.005 |
| R-HSA-422475 | Axon guidance | 1.016328e-02 | 1.993 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.226837e-02 | 1.911 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.234639e-02 | 1.908 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.263851e-02 | 1.898 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.300682e-02 | 1.886 |
| R-HSA-9675108 | Nervous system development | 1.443109e-02 | 1.841 |
| R-HSA-163282 | Mitochondrial transcription initiation | 1.571229e-02 | 1.804 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.578864e-02 | 1.802 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.130224e-02 | 1.672 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 2.089530e-02 | 1.680 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.833257e-02 | 1.737 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.198656e-02 | 1.658 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.490790e-02 | 1.604 |
| R-HSA-8941237 | Invadopodia formation | 2.605135e-02 | 1.584 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.661688e-02 | 1.575 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.693855e-02 | 1.570 |
| R-HSA-72172 | mRNA Splicing | 3.118767e-02 | 1.506 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.247324e-02 | 1.488 |
| R-HSA-8849472 | PTK6 Down-Regulation | 3.628307e-02 | 1.440 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.632618e-02 | 1.440 |
| R-HSA-8953854 | Metabolism of RNA | 3.671786e-02 | 1.435 |
| R-HSA-9824446 | Viral Infection Pathways | 3.900985e-02 | 1.409 |
| R-HSA-69481 | G2/M Checkpoints | 3.970904e-02 | 1.401 |
| R-HSA-72187 | mRNA 3'-end processing | 4.042655e-02 | 1.393 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.769364e-02 | 1.322 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 5.642890e-02 | 1.248 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 6.634517e-02 | 1.178 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.187687e-02 | 1.285 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.007583e-02 | 1.221 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 5.642890e-02 | 1.248 |
| R-HSA-9613354 | Lipophagy | 6.139997e-02 | 1.212 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.231888e-02 | 1.205 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 6.634517e-02 | 1.178 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.722419e-02 | 1.172 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.999674e-02 | 1.222 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.164240e-02 | 1.145 |
| R-HSA-597592 | Post-translational protein modification | 5.677756e-02 | 1.246 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 5.729543e-02 | 1.242 |
| R-HSA-109582 | Hemostasis | 6.239027e-02 | 1.205 |
| R-HSA-9020591 | Interleukin-12 signaling | 7.313577e-02 | 1.136 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 7.615844e-02 | 1.118 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.075090e-02 | 1.093 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.075090e-02 | 1.093 |
| R-HSA-877312 | Regulation of IFNG signaling | 8.102678e-02 | 1.091 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.703882e-02 | 1.060 |
| R-HSA-447115 | Interleukin-12 family signaling | 9.180163e-02 | 1.037 |
| R-HSA-2262752 | Cellular responses to stress | 9.721157e-02 | 1.012 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 9.830450e-02 | 1.007 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.600138e-01 | 0.796 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.688535e-01 | 0.772 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.732388e-01 | 0.761 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.776013e-01 | 0.751 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.776013e-01 | 0.751 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.862580e-01 | 0.730 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.862580e-01 | 0.730 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.905526e-01 | 0.720 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.948247e-01 | 0.710 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.990746e-01 | 0.701 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.948247e-01 | 0.710 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.144025e-01 | 0.942 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.732388e-01 | 0.761 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.732388e-01 | 0.761 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.555592e-01 | 0.808 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.144025e-01 | 0.942 |
| R-HSA-5334118 | DNA methylation | 1.688535e-01 | 0.772 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.905526e-01 | 0.720 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.948247e-01 | 0.710 |
| R-HSA-429947 | Deadenylation of mRNA | 1.465798e-01 | 0.834 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.097089e-01 | 0.960 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 1.375061e-01 | 0.862 |
| R-HSA-2142845 | Hyaluronan metabolism | 1.948247e-01 | 0.710 |
| R-HSA-2160916 | Hyaluronan degradation | 1.510813e-01 | 0.821 |
| R-HSA-77387 | Insulin receptor recycling | 1.644452e-01 | 0.784 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.420548e-01 | 0.848 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.653325e-01 | 0.782 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.905526e-01 | 0.720 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.237526e-01 | 0.907 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.420548e-01 | 0.848 |
| R-HSA-111933 | Calmodulin induced events | 2.033023e-01 | 0.692 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.433131e-01 | 0.844 |
| R-HSA-73894 | DNA Repair | 1.417616e-01 | 0.848 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.237164e-01 | 0.908 |
| R-HSA-111997 | CaM pathway | 2.033023e-01 | 0.692 |
| R-HSA-5693538 | Homology Directed Repair | 1.542442e-01 | 0.812 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.375061e-01 | 0.862 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.862580e-01 | 0.730 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.990746e-01 | 0.701 |
| R-HSA-354192 | Integrin signaling | 1.862580e-01 | 0.730 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.819410e-01 | 0.740 |
| R-HSA-8939211 | ESR-mediated signaling | 1.548711e-01 | 0.810 |
| R-HSA-1280218 | Adaptive Immune System | 2.009910e-01 | 0.697 |
| R-HSA-392499 | Metabolism of proteins | 2.053376e-01 | 0.688 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.070221e-01 | 0.684 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.075079e-01 | 0.683 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.089465e-01 | 0.680 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.116916e-01 | 0.674 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.158535e-01 | 0.666 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.199936e-01 | 0.658 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.199936e-01 | 0.658 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.199936e-01 | 0.658 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.199936e-01 | 0.658 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.241122e-01 | 0.650 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.241122e-01 | 0.650 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.241122e-01 | 0.650 |
| R-HSA-165159 | MTOR signalling | 2.322849e-01 | 0.634 |
| R-HSA-111996 | Ca-dependent events | 2.322849e-01 | 0.634 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.443847e-01 | 0.612 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.443847e-01 | 0.612 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.443847e-01 | 0.612 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.483760e-01 | 0.605 |
| R-HSA-75153 | Apoptotic execution phase | 2.483760e-01 | 0.605 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.523464e-01 | 0.598 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.562961e-01 | 0.591 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.562961e-01 | 0.591 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.716396e-01 | 0.566 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.718897e-01 | 0.566 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.718897e-01 | 0.566 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.757373e-01 | 0.560 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.757373e-01 | 0.560 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.757373e-01 | 0.560 |
| R-HSA-1221632 | Meiotic synapsis | 2.757373e-01 | 0.560 |
| R-HSA-168255 | Influenza Infection | 2.809427e-01 | 0.551 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.871601e-01 | 0.542 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.909279e-01 | 0.536 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.909279e-01 | 0.536 |
| R-HSA-5663205 | Infectious disease | 2.916321e-01 | 0.535 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.946761e-01 | 0.531 |
| R-HSA-191859 | snRNP Assembly | 2.984047e-01 | 0.525 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.984047e-01 | 0.525 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.984047e-01 | 0.525 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.984047e-01 | 0.525 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.058036e-01 | 0.515 |
| R-HSA-112043 | PLC beta mediated events | 3.058036e-01 | 0.515 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.094741e-01 | 0.509 |
| R-HSA-8848021 | Signaling by PTK6 | 3.131254e-01 | 0.504 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.131254e-01 | 0.504 |
| R-HSA-112040 | G-protein mediated events | 3.275408e-01 | 0.485 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.292477e-01 | 0.482 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.310976e-01 | 0.480 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.416571e-01 | 0.466 |
| R-HSA-1266738 | Developmental Biology | 3.431063e-01 | 0.465 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.451401e-01 | 0.462 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.451401e-01 | 0.462 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.486050e-01 | 0.458 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.520517e-01 | 0.453 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.554804e-01 | 0.449 |
| R-HSA-74160 | Gene expression (Transcription) | 3.576095e-01 | 0.447 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.656594e-01 | 0.437 |
| R-HSA-9659379 | Sensory processing of sound | 3.690169e-01 | 0.433 |
| R-HSA-6806834 | Signaling by MET | 3.723569e-01 | 0.429 |
| R-HSA-162906 | HIV Infection | 3.753491e-01 | 0.426 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.772333e-01 | 0.423 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.855430e-01 | 0.414 |
| R-HSA-1500620 | Meiosis | 3.887965e-01 | 0.410 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.920330e-01 | 0.407 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.920330e-01 | 0.407 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.920330e-01 | 0.407 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.952526e-01 | 0.403 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.173225e-01 | 0.380 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.234807e-01 | 0.373 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.295745e-01 | 0.367 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.325975e-01 | 0.364 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.385961e-01 | 0.358 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.415719e-01 | 0.355 |
| R-HSA-162582 | Signal Transduction | 4.440554e-01 | 0.353 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.445321e-01 | 0.352 |
| R-HSA-70171 | Glycolysis | 4.445321e-01 | 0.352 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.504060e-01 | 0.346 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.504060e-01 | 0.346 |
| R-HSA-111885 | Opioid Signalling | 4.562185e-01 | 0.341 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.562185e-01 | 0.341 |
| R-HSA-9833110 | RSV-host interactions | 4.591019e-01 | 0.338 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.610584e-01 | 0.336 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.619702e-01 | 0.335 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.648235e-01 | 0.333 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.676618e-01 | 0.330 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.676618e-01 | 0.330 |
| R-HSA-211000 | Gene Silencing by RNA | 4.676618e-01 | 0.330 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.732939e-01 | 0.325 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.816318e-01 | 0.317 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.871178e-01 | 0.312 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.898393e-01 | 0.310 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.925465e-01 | 0.308 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.952394e-01 | 0.305 |
| R-HSA-70326 | Glucose metabolism | 5.005831e-01 | 0.301 |
| R-HSA-68875 | Mitotic Prophase | 5.084939e-01 | 0.294 |
| R-HSA-3371556 | Cellular response to heat stress | 5.111033e-01 | 0.291 |
| R-HSA-69206 | G1/S Transition | 5.239460e-01 | 0.281 |
| R-HSA-114608 | Platelet degranulation | 5.289892e-01 | 0.277 |
| R-HSA-1474165 | Reproduction | 5.389177e-01 | 0.268 |
| R-HSA-9843745 | Adipogenesis | 5.413674e-01 | 0.267 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.462281e-01 | 0.263 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.581585e-01 | 0.253 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.605071e-01 | 0.251 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.720663e-01 | 0.243 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.810969e-01 | 0.236 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.827248e-01 | 0.235 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.921207e-01 | 0.228 |
| R-HSA-69306 | DNA Replication | 5.964495e-01 | 0.224 |
| R-HSA-73887 | Death Receptor Signaling | 5.985968e-01 | 0.223 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.007329e-01 | 0.221 |
| R-HSA-9610379 | HCMV Late Events | 6.049713e-01 | 0.218 |
| R-HSA-162587 | HIV Life Cycle | 6.049713e-01 | 0.218 |
| R-HSA-877300 | Interferon gamma signaling | 6.091653e-01 | 0.215 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.112458e-01 | 0.214 |
| R-HSA-109581 | Apoptosis | 6.153740e-01 | 0.211 |
| R-HSA-5619102 | SLC transporter disorders | 6.255058e-01 | 0.204 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.334209e-01 | 0.198 |
| R-HSA-72306 | tRNA processing | 6.334209e-01 | 0.198 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.373163e-01 | 0.196 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.392486e-01 | 0.194 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.392486e-01 | 0.194 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.392486e-01 | 0.194 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.430827e-01 | 0.192 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.670414e-01 | 0.176 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 6.758269e-01 | 0.170 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.809878e-01 | 0.167 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.877429e-01 | 0.163 |
| R-HSA-5357801 | Programmed Cell Death | 6.976114e-01 | 0.156 |
| R-HSA-397014 | Muscle contraction | 7.087356e-01 | 0.150 |
| R-HSA-418990 | Adherens junctions interactions | 7.179481e-01 | 0.144 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.198851e-01 | 0.143 |
| R-HSA-8951664 | Neddylation | 7.224457e-01 | 0.141 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.305736e-01 | 0.136 |
| R-HSA-168256 | Immune System | 7.335197e-01 | 0.135 |
| R-HSA-72312 | rRNA processing | 7.383389e-01 | 0.132 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.411303e-01 | 0.130 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.585710e-01 | 0.120 |
| R-HSA-4839726 | Chromatin organization | 7.611490e-01 | 0.119 |
| R-HSA-421270 | Cell-cell junction organization | 7.636998e-01 | 0.117 |
| R-HSA-5688426 | Deubiquitination | 7.687210e-01 | 0.114 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.699598e-01 | 0.114 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.843228e-01 | 0.106 |
| R-HSA-446728 | Cell junction organization | 7.956121e-01 | 0.099 |
| R-HSA-9679506 | SARS-CoV Infections | 8.121768e-01 | 0.090 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.132217e-01 | 0.090 |
| R-HSA-1500931 | Cell-Cell communication | 8.334313e-01 | 0.079 |
| R-HSA-1643685 | Disease | 8.448902e-01 | 0.073 |
| R-HSA-1474244 | Extracellular matrix organization | 8.463766e-01 | 0.072 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.552330e-01 | 0.068 |
| R-HSA-449147 | Signaling by Interleukins | 8.597803e-01 | 0.066 |
| R-HSA-418594 | G alpha (i) signalling events | 8.987105e-01 | 0.046 |
| R-HSA-72766 | Translation | 9.101088e-01 | 0.041 |
| R-HSA-388396 | GPCR downstream signalling | 9.267954e-01 | 0.033 |
| R-HSA-212436 | Generic Transcription Pathway | 9.268913e-01 | 0.033 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.437217e-01 | 0.025 |
| R-HSA-372790 | Signaling by GPCR | 9.497336e-01 | 0.022 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.670987e-01 | 0.015 |
| R-HSA-9709957 | Sensory Perception | 9.990063e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.801 | 0.687 | 1 | 0.882 |
CDK1 |
0.789 | 0.674 | 1 | 0.872 |
P38G |
0.781 | 0.658 | 1 | 0.894 |
CDK5 |
0.781 | 0.637 | 1 | 0.823 |
CLK3 |
0.779 | 0.466 | 1 | 0.638 |
KIS |
0.777 | 0.543 | 1 | 0.817 |
CDK18 |
0.776 | 0.605 | 1 | 0.862 |
CDK17 |
0.776 | 0.624 | 1 | 0.883 |
JNK2 |
0.775 | 0.659 | 1 | 0.868 |
CDK8 |
0.775 | 0.598 | 1 | 0.859 |
CDK19 |
0.772 | 0.584 | 1 | 0.879 |
CDK2 |
0.772 | 0.607 | 1 | 0.793 |
CDK7 |
0.769 | 0.579 | 1 | 0.845 |
HIPK2 |
0.769 | 0.548 | 1 | 0.847 |
JNK3 |
0.768 | 0.649 | 1 | 0.850 |
P38D |
0.767 | 0.621 | 1 | 0.871 |
CDK16 |
0.767 | 0.593 | 1 | 0.867 |
ERK1 |
0.764 | 0.603 | 1 | 0.843 |
CDK13 |
0.764 | 0.584 | 1 | 0.848 |
P38B |
0.762 | 0.595 | 1 | 0.839 |
CDK12 |
0.760 | 0.583 | 1 | 0.858 |
CLK1 |
0.760 | 0.373 | -3 | 0.562 |
NLK |
0.759 | 0.549 | 1 | 0.660 |
CDK9 |
0.758 | 0.574 | 1 | 0.845 |
DYRK2 |
0.758 | 0.520 | 1 | 0.805 |
ERK2 |
0.756 | 0.607 | 1 | 0.812 |
JNK1 |
0.755 | 0.584 | 1 | 0.871 |
P38A |
0.753 | 0.575 | 1 | 0.792 |
CDK6 |
0.753 | 0.590 | 1 | 0.839 |
CLK4 |
0.753 | 0.322 | -3 | 0.580 |
CLK2 |
0.752 | 0.317 | -3 | 0.580 |
CDK10 |
0.751 | 0.539 | 1 | 0.846 |
COT |
0.751 | 0.063 | 2 | 0.788 |
HIPK1 |
0.750 | 0.486 | 1 | 0.793 |
DYRK4 |
0.750 | 0.526 | 1 | 0.871 |
SRPK1 |
0.750 | 0.236 | -3 | 0.559 |
HIPK4 |
0.750 | 0.319 | 1 | 0.626 |
CDK14 |
0.749 | 0.559 | 1 | 0.837 |
CDK4 |
0.748 | 0.582 | 1 | 0.857 |
DYRK1B |
0.747 | 0.512 | 1 | 0.836 |
ERK5 |
0.743 | 0.266 | 1 | 0.573 |
MTOR |
0.743 | 0.170 | 1 | 0.475 |
SRPK2 |
0.742 | 0.185 | -3 | 0.495 |
DYRK1A |
0.740 | 0.413 | 1 | 0.767 |
HIPK3 |
0.734 | 0.450 | 1 | 0.745 |
PRP4 |
0.733 | 0.349 | -3 | 0.639 |
ICK |
0.733 | 0.228 | -3 | 0.626 |
DYRK3 |
0.732 | 0.373 | 1 | 0.762 |
CDC7 |
0.731 | -0.071 | 1 | 0.378 |
PIM3 |
0.731 | -0.021 | -3 | 0.646 |
CHAK2 |
0.729 | 0.086 | -1 | 0.830 |
MOS |
0.729 | -0.019 | 1 | 0.393 |
MST4 |
0.729 | 0.031 | 2 | 0.760 |
CDKL1 |
0.728 | 0.071 | -3 | 0.600 |
PRPK |
0.728 | -0.077 | -1 | 0.735 |
PRKD1 |
0.727 | -0.003 | -3 | 0.613 |
CAMK1B |
0.727 | -0.020 | -3 | 0.658 |
CDKL5 |
0.726 | 0.076 | -3 | 0.591 |
PKN3 |
0.726 | -0.020 | -3 | 0.623 |
NDR2 |
0.726 | -0.034 | -3 | 0.644 |
PRKD2 |
0.726 | 0.016 | -3 | 0.578 |
PKCD |
0.726 | 0.040 | 2 | 0.714 |
SKMLCK |
0.726 | -0.003 | -2 | 0.839 |
RSK2 |
0.726 | -0.007 | -3 | 0.589 |
IKKA |
0.726 | -0.021 | -2 | 0.677 |
NUAK2 |
0.726 | 0.020 | -3 | 0.641 |
PIM1 |
0.725 | 0.029 | -3 | 0.589 |
GRK7 |
0.725 | 0.081 | 1 | 0.360 |
AMPKA1 |
0.725 | 0.004 | -3 | 0.647 |
TBK1 |
0.724 | -0.115 | 1 | 0.274 |
TSSK1 |
0.724 | 0.032 | -3 | 0.673 |
MARK4 |
0.724 | -0.008 | 4 | 0.827 |
ULK2 |
0.724 | -0.114 | 2 | 0.724 |
MAPKAPK2 |
0.723 | -0.006 | -3 | 0.546 |
BMPR1B |
0.723 | 0.048 | 1 | 0.396 |
IKKB |
0.723 | -0.123 | -2 | 0.691 |
GCN2 |
0.723 | -0.125 | 2 | 0.718 |
MAK |
0.722 | 0.327 | -2 | 0.666 |
GRK1 |
0.722 | -0.010 | -2 | 0.678 |
DSTYK |
0.722 | -0.101 | 2 | 0.791 |
ATR |
0.722 | -0.060 | 1 | 0.350 |
BMPR2 |
0.721 | -0.108 | -2 | 0.815 |
MAPKAPK3 |
0.721 | -0.030 | -3 | 0.569 |
NIK |
0.720 | -0.024 | -3 | 0.677 |
SRPK3 |
0.720 | 0.124 | -3 | 0.530 |
MNK2 |
0.720 | 0.040 | -2 | 0.799 |
RAF1 |
0.720 | -0.184 | 1 | 0.329 |
TGFBR2 |
0.720 | -0.046 | -2 | 0.730 |
CAMK2G |
0.720 | -0.077 | 2 | 0.699 |
AMPKA2 |
0.719 | -0.004 | -3 | 0.621 |
TSSK2 |
0.719 | -0.004 | -5 | 0.684 |
WNK1 |
0.719 | -0.039 | -2 | 0.840 |
P90RSK |
0.719 | -0.032 | -3 | 0.590 |
PKN2 |
0.719 | -0.038 | -3 | 0.623 |
PKCB |
0.719 | 0.024 | 2 | 0.683 |
NDR1 |
0.719 | -0.050 | -3 | 0.636 |
LATS2 |
0.719 | -0.025 | -5 | 0.606 |
IKKE |
0.718 | -0.145 | 1 | 0.274 |
ERK7 |
0.718 | 0.197 | 2 | 0.487 |
RSK3 |
0.718 | -0.028 | -3 | 0.589 |
GRK6 |
0.717 | -0.034 | 1 | 0.370 |
LATS1 |
0.717 | 0.035 | -3 | 0.663 |
GRK5 |
0.717 | -0.100 | -3 | 0.665 |
TGFBR1 |
0.717 | 0.025 | -2 | 0.761 |
CAMLCK |
0.717 | -0.024 | -2 | 0.817 |
PDHK4 |
0.716 | -0.230 | 1 | 0.385 |
NUAK1 |
0.716 | 0.000 | -3 | 0.597 |
ULK1 |
0.716 | -0.110 | -3 | 0.611 |
NEK6 |
0.715 | -0.090 | -2 | 0.798 |
MLK1 |
0.715 | -0.082 | 2 | 0.745 |
PKACG |
0.715 | -0.017 | -2 | 0.735 |
AURC |
0.715 | 0.019 | -2 | 0.670 |
HUNK |
0.714 | -0.116 | 2 | 0.752 |
P70S6KB |
0.714 | -0.032 | -3 | 0.599 |
ALK4 |
0.714 | 0.017 | -2 | 0.777 |
DAPK2 |
0.714 | -0.052 | -3 | 0.657 |
NEK7 |
0.713 | -0.143 | -3 | 0.627 |
CAMK2D |
0.713 | -0.087 | -3 | 0.618 |
QSK |
0.713 | -0.009 | 4 | 0.809 |
MNK1 |
0.712 | 0.030 | -2 | 0.798 |
FAM20C |
0.712 | 0.031 | 2 | 0.576 |
PAK6 |
0.712 | 0.043 | -2 | 0.696 |
CAMK2A |
0.712 | -0.016 | 2 | 0.666 |
RSK4 |
0.712 | -0.006 | -3 | 0.570 |
MLK3 |
0.711 | -0.011 | 2 | 0.683 |
CAMK2B |
0.711 | -0.032 | 2 | 0.665 |
GSK3A |
0.711 | 0.143 | 4 | 0.361 |
PRKD3 |
0.711 | -0.013 | -3 | 0.547 |
DLK |
0.710 | -0.133 | 1 | 0.379 |
NIM1 |
0.710 | -0.073 | 3 | 0.554 |
PKCZ |
0.710 | 0.007 | 2 | 0.717 |
PKCA |
0.710 | -0.007 | 2 | 0.669 |
PDHK1 |
0.710 | -0.234 | 1 | 0.358 |
MARK3 |
0.710 | 0.009 | 4 | 0.783 |
MELK |
0.710 | -0.047 | -3 | 0.603 |
PKCG |
0.709 | -0.020 | 2 | 0.675 |
RIPK3 |
0.709 | -0.150 | 3 | 0.489 |
NEK9 |
0.709 | -0.137 | 2 | 0.769 |
BMPR1A |
0.709 | 0.039 | 1 | 0.389 |
MARK2 |
0.709 | -0.000 | 4 | 0.771 |
MOK |
0.709 | 0.282 | 1 | 0.685 |
PKCH |
0.708 | -0.016 | 2 | 0.675 |
SIK |
0.708 | -0.025 | -3 | 0.563 |
PKG2 |
0.708 | 0.004 | -2 | 0.687 |
MLK2 |
0.708 | -0.115 | 2 | 0.753 |
WNK3 |
0.708 | -0.166 | 1 | 0.302 |
CHAK1 |
0.708 | -0.018 | 2 | 0.708 |
PLK1 |
0.708 | -0.067 | -2 | 0.748 |
DCAMKL1 |
0.707 | -0.001 | -3 | 0.603 |
PKACB |
0.707 | 0.004 | -2 | 0.694 |
ATM |
0.707 | -0.059 | 1 | 0.301 |
PKR |
0.707 | -0.004 | 1 | 0.325 |
PHKG1 |
0.707 | -0.061 | -3 | 0.620 |
BCKDK |
0.707 | -0.161 | -1 | 0.700 |
SGK3 |
0.707 | -0.007 | -3 | 0.562 |
ACVR2B |
0.707 | -0.023 | -2 | 0.729 |
PLK3 |
0.707 | 0.020 | 2 | 0.661 |
PRKX |
0.706 | 0.028 | -3 | 0.519 |
ACVR2A |
0.706 | -0.021 | -2 | 0.718 |
IRE1 |
0.706 | -0.083 | 1 | 0.288 |
PAK1 |
0.705 | -0.043 | -2 | 0.760 |
AKT2 |
0.705 | 0.006 | -3 | 0.509 |
MLK4 |
0.705 | -0.036 | 2 | 0.665 |
ALK2 |
0.705 | -0.009 | -2 | 0.751 |
MASTL |
0.704 | -0.212 | -2 | 0.754 |
QIK |
0.704 | -0.079 | -3 | 0.616 |
VRK2 |
0.704 | -0.003 | 1 | 0.432 |
PAK3 |
0.704 | -0.065 | -2 | 0.768 |
MSK2 |
0.704 | -0.061 | -3 | 0.534 |
PINK1 |
0.704 | 0.099 | 1 | 0.476 |
SMG1 |
0.703 | -0.045 | 1 | 0.310 |
CAMK4 |
0.703 | -0.109 | -3 | 0.614 |
CHK1 |
0.703 | -0.038 | -3 | 0.662 |
CK2A2 |
0.703 | 0.047 | 1 | 0.343 |
ANKRD3 |
0.703 | -0.159 | 1 | 0.344 |
TTBK2 |
0.703 | -0.135 | 2 | 0.662 |
MEK1 |
0.703 | -0.098 | 2 | 0.755 |
GRK4 |
0.702 | -0.126 | -2 | 0.721 |
BRSK1 |
0.702 | -0.053 | -3 | 0.591 |
YSK4 |
0.702 | -0.117 | 1 | 0.308 |
MSK1 |
0.701 | -0.037 | -3 | 0.545 |
IRE2 |
0.701 | -0.080 | 2 | 0.717 |
PLK4 |
0.701 | -0.080 | 2 | 0.596 |
SSTK |
0.700 | -0.004 | 4 | 0.780 |
GRK2 |
0.700 | -0.041 | -2 | 0.628 |
MYLK4 |
0.699 | -0.041 | -2 | 0.769 |
NEK2 |
0.699 | -0.110 | 2 | 0.748 |
AURB |
0.699 | -0.017 | -2 | 0.664 |
TAO3 |
0.699 | 0.010 | 1 | 0.349 |
BRSK2 |
0.698 | -0.077 | -3 | 0.603 |
DCAMKL2 |
0.698 | -0.024 | -3 | 0.623 |
MARK1 |
0.698 | -0.045 | 4 | 0.789 |
MST3 |
0.698 | -0.014 | 2 | 0.755 |
TLK2 |
0.697 | -0.091 | 1 | 0.285 |
PKCT |
0.696 | -0.033 | 2 | 0.680 |
RIPK1 |
0.696 | -0.232 | 1 | 0.304 |
ZAK |
0.696 | -0.086 | 1 | 0.352 |
DRAK1 |
0.695 | -0.109 | 1 | 0.342 |
PIM2 |
0.695 | -0.033 | -3 | 0.556 |
PKCE |
0.694 | 0.025 | 2 | 0.670 |
AKT1 |
0.694 | -0.007 | -3 | 0.521 |
DNAPK |
0.694 | -0.077 | 1 | 0.268 |
AURA |
0.694 | -0.026 | -2 | 0.631 |
PKACA |
0.694 | -0.007 | -2 | 0.653 |
IRAK4 |
0.694 | -0.070 | 1 | 0.275 |
PLK2 |
0.694 | 0.119 | -3 | 0.833 |
CK1E |
0.693 | -0.049 | -3 | 0.403 |
CAMK1G |
0.693 | -0.061 | -3 | 0.554 |
PAK2 |
0.693 | -0.084 | -2 | 0.739 |
MPSK1 |
0.693 | 0.002 | 1 | 0.338 |
MAPKAPK5 |
0.693 | -0.102 | -3 | 0.501 |
CK2A1 |
0.692 | 0.026 | 1 | 0.337 |
PHKG2 |
0.692 | -0.067 | -3 | 0.602 |
PASK |
0.692 | -0.040 | -3 | 0.648 |
MEKK2 |
0.691 | -0.067 | 2 | 0.742 |
PKCI |
0.691 | -0.019 | 2 | 0.687 |
MEKK1 |
0.691 | -0.125 | 1 | 0.334 |
BRAF |
0.691 | -0.110 | -4 | 0.776 |
PAK5 |
0.691 | -0.010 | -2 | 0.632 |
GAK |
0.689 | 0.007 | 1 | 0.375 |
NEK5 |
0.689 | -0.106 | 1 | 0.298 |
CAMK1D |
0.689 | -0.039 | -3 | 0.504 |
MEKK3 |
0.689 | -0.137 | 1 | 0.345 |
GRK3 |
0.688 | -0.045 | -2 | 0.578 |
MEK5 |
0.688 | -0.166 | 2 | 0.744 |
PAK4 |
0.688 | -0.001 | -2 | 0.643 |
GSK3B |
0.687 | 0.000 | 4 | 0.351 |
TAO2 |
0.686 | -0.036 | 2 | 0.771 |
TNIK |
0.686 | 0.037 | 3 | 0.730 |
WNK4 |
0.686 | -0.123 | -2 | 0.815 |
PERK |
0.686 | -0.144 | -2 | 0.742 |
SBK |
0.685 | 0.046 | -3 | 0.412 |
SGK1 |
0.685 | 0.004 | -3 | 0.443 |
EEF2K |
0.685 | 0.009 | 3 | 0.724 |
AKT3 |
0.685 | -0.004 | -3 | 0.454 |
SMMLCK |
0.685 | -0.063 | -3 | 0.605 |
P70S6K |
0.685 | -0.077 | -3 | 0.509 |
CK1G1 |
0.684 | -0.080 | -3 | 0.396 |
HRI |
0.683 | -0.165 | -2 | 0.773 |
PKN1 |
0.683 | -0.051 | -3 | 0.522 |
SNRK |
0.683 | -0.187 | 2 | 0.615 |
MST2 |
0.683 | -0.058 | 1 | 0.322 |
TLK1 |
0.683 | -0.123 | -2 | 0.772 |
GCK |
0.683 | -0.050 | 1 | 0.331 |
PDK1 |
0.683 | -0.066 | 1 | 0.325 |
MAP3K15 |
0.682 | -0.069 | 1 | 0.336 |
HGK |
0.682 | -0.031 | 3 | 0.697 |
CK1D |
0.682 | -0.053 | -3 | 0.343 |
CAMK1A |
0.681 | -0.028 | -3 | 0.476 |
LKB1 |
0.680 | -0.085 | -3 | 0.620 |
MEKK6 |
0.680 | -0.092 | 1 | 0.338 |
MINK |
0.680 | -0.052 | 1 | 0.297 |
CK1A2 |
0.680 | -0.061 | -3 | 0.343 |
CHK2 |
0.679 | -0.041 | -3 | 0.463 |
NEK11 |
0.679 | -0.144 | 1 | 0.341 |
DAPK3 |
0.679 | -0.049 | -3 | 0.602 |
MRCKA |
0.678 | -0.004 | -3 | 0.558 |
LOK |
0.678 | -0.040 | -2 | 0.739 |
ROCK2 |
0.678 | -0.007 | -3 | 0.591 |
MRCKB |
0.677 | -0.012 | -3 | 0.542 |
NEK8 |
0.677 | -0.149 | 2 | 0.745 |
KHS1 |
0.677 | -0.036 | 1 | 0.295 |
LRRK2 |
0.677 | -0.031 | 2 | 0.762 |
KHS2 |
0.676 | -0.012 | 1 | 0.313 |
SLK |
0.675 | -0.024 | -2 | 0.664 |
VRK1 |
0.675 | -0.116 | 2 | 0.791 |
BUB1 |
0.675 | -0.012 | -5 | 0.630 |
HPK1 |
0.674 | -0.086 | 1 | 0.319 |
MST1 |
0.674 | -0.068 | 1 | 0.300 |
DAPK1 |
0.673 | -0.053 | -3 | 0.580 |
CAMKK1 |
0.673 | -0.201 | -2 | 0.703 |
TTBK1 |
0.673 | -0.160 | 2 | 0.580 |
IRAK1 |
0.672 | -0.216 | -1 | 0.655 |
NEK4 |
0.671 | -0.172 | 1 | 0.275 |
OSR1 |
0.671 | -0.011 | 2 | 0.716 |
NEK1 |
0.671 | -0.138 | 1 | 0.278 |
YSK1 |
0.670 | -0.088 | 2 | 0.739 |
PBK |
0.669 | -0.059 | 1 | 0.320 |
CAMKK2 |
0.669 | -0.186 | -2 | 0.703 |
TAK1 |
0.668 | -0.174 | 1 | 0.303 |
PKG1 |
0.668 | -0.038 | -2 | 0.620 |
HASPIN |
0.668 | -0.010 | -1 | 0.590 |
DMPK1 |
0.667 | -0.003 | -3 | 0.572 |
STK33 |
0.666 | -0.114 | 2 | 0.540 |
BIKE |
0.665 | -0.016 | 1 | 0.327 |
MEK2 |
0.664 | -0.175 | 2 | 0.747 |
ROCK1 |
0.664 | -0.026 | -3 | 0.559 |
TTK |
0.664 | -0.032 | -2 | 0.749 |
AAK1 |
0.661 | 0.019 | 1 | 0.300 |
TAO1 |
0.660 | -0.058 | 1 | 0.292 |
ASK1 |
0.659 | -0.095 | 1 | 0.336 |
MYO3A |
0.659 | -0.035 | 1 | 0.296 |
PDHK3_TYR |
0.659 | 0.080 | 4 | 0.810 |
NEK3 |
0.657 | -0.158 | 1 | 0.303 |
RIPK2 |
0.657 | -0.244 | 1 | 0.299 |
CRIK |
0.657 | -0.043 | -3 | 0.516 |
MYO3B |
0.657 | -0.059 | 2 | 0.756 |
LIMK2_TYR |
0.651 | 0.073 | -3 | 0.685 |
CK1A |
0.650 | -0.078 | -3 | 0.273 |
TESK1_TYR |
0.650 | -0.015 | 3 | 0.680 |
PKMYT1_TYR |
0.647 | 0.006 | 3 | 0.609 |
PDHK4_TYR |
0.646 | -0.035 | 2 | 0.746 |
ALPHAK3 |
0.646 | -0.081 | -1 | 0.658 |
STLK3 |
0.646 | -0.133 | 1 | 0.308 |
BMPR2_TYR |
0.646 | -0.006 | -1 | 0.737 |
MAP2K7_TYR |
0.644 | -0.106 | 2 | 0.760 |
MAP2K6_TYR |
0.644 | -0.044 | -1 | 0.752 |
MAP2K4_TYR |
0.644 | -0.097 | -1 | 0.746 |
PDHK1_TYR |
0.641 | -0.078 | -1 | 0.763 |
PINK1_TYR |
0.641 | -0.115 | 1 | 0.376 |
LIMK1_TYR |
0.639 | -0.037 | 2 | 0.777 |
TXK |
0.638 | -0.002 | 1 | 0.391 |
YANK3 |
0.638 | -0.097 | 2 | 0.334 |
EPHA6 |
0.638 | -0.059 | -1 | 0.746 |
TYRO3 |
0.636 | -0.085 | 3 | 0.562 |
RET |
0.636 | -0.120 | 1 | 0.331 |
YES1 |
0.636 | -0.024 | -1 | 0.748 |
CSF1R |
0.635 | -0.060 | 3 | 0.523 |
EPHB4 |
0.635 | -0.091 | -1 | 0.747 |
ROS1 |
0.634 | -0.115 | 3 | 0.531 |
TNNI3K_TYR |
0.633 | -0.024 | 1 | 0.373 |
DDR1 |
0.633 | -0.118 | 4 | 0.727 |
JAK2 |
0.630 | -0.152 | 1 | 0.341 |
TYK2 |
0.630 | -0.203 | 1 | 0.311 |
ITK |
0.629 | -0.078 | -1 | 0.695 |
MST1R |
0.627 | -0.162 | 3 | 0.539 |
ABL2 |
0.627 | -0.090 | -1 | 0.683 |
JAK3 |
0.627 | -0.135 | 1 | 0.344 |
FER |
0.625 | -0.147 | 1 | 0.364 |
FGFR2 |
0.625 | -0.082 | 3 | 0.526 |
INSRR |
0.624 | -0.130 | 3 | 0.493 |
LCK |
0.624 | -0.063 | -1 | 0.713 |
HCK |
0.624 | -0.110 | -1 | 0.717 |
BLK |
0.623 | -0.050 | -1 | 0.720 |
NEK10_TYR |
0.623 | -0.130 | 1 | 0.254 |
EPHB1 |
0.623 | -0.142 | 1 | 0.366 |
TNK1 |
0.623 | -0.095 | 3 | 0.528 |
FGFR1 |
0.623 | -0.087 | 3 | 0.499 |
EPHB2 |
0.623 | -0.102 | -1 | 0.724 |
ABL1 |
0.623 | -0.106 | -1 | 0.677 |
FGR |
0.623 | -0.171 | 1 | 0.342 |
TEK |
0.622 | -0.061 | 3 | 0.490 |
EPHA4 |
0.622 | -0.105 | 2 | 0.651 |
CK1G3 |
0.622 | -0.098 | -3 | 0.230 |
PDGFRB |
0.622 | -0.169 | 3 | 0.544 |
SRMS |
0.621 | -0.132 | 1 | 0.357 |
JAK1 |
0.621 | -0.131 | 1 | 0.306 |
KIT |
0.621 | -0.124 | 3 | 0.521 |
MERTK |
0.620 | -0.108 | 3 | 0.500 |
DDR2 |
0.620 | -0.063 | 3 | 0.475 |
EPHB3 |
0.620 | -0.151 | -1 | 0.735 |
FYN |
0.620 | -0.035 | -1 | 0.691 |
AXL |
0.620 | -0.144 | 3 | 0.504 |
TNK2 |
0.620 | -0.150 | 3 | 0.486 |
KDR |
0.619 | -0.118 | 3 | 0.487 |
BMX |
0.619 | -0.086 | -1 | 0.632 |
TEC |
0.618 | -0.086 | -1 | 0.656 |
MET |
0.617 | -0.116 | 3 | 0.508 |
WEE1_TYR |
0.617 | -0.081 | -1 | 0.646 |
FLT3 |
0.617 | -0.147 | 3 | 0.541 |
BTK |
0.616 | -0.123 | -1 | 0.676 |
FGFR3 |
0.616 | -0.082 | 3 | 0.500 |
EGFR |
0.614 | -0.070 | 1 | 0.309 |
ALK |
0.613 | -0.150 | 3 | 0.448 |
PDGFRA |
0.613 | -0.200 | 3 | 0.548 |
EPHA7 |
0.612 | -0.127 | 2 | 0.662 |
INSR |
0.612 | -0.146 | 3 | 0.474 |
PTK6 |
0.612 | -0.145 | -1 | 0.624 |
SRC |
0.611 | -0.072 | -1 | 0.694 |
PTK2B |
0.611 | -0.104 | -1 | 0.677 |
NTRK1 |
0.610 | -0.194 | -1 | 0.698 |
FRK |
0.610 | -0.106 | -1 | 0.721 |
MATK |
0.609 | -0.077 | -1 | 0.612 |
LTK |
0.609 | -0.157 | 3 | 0.464 |
FLT1 |
0.609 | -0.149 | -1 | 0.696 |
ERBB2 |
0.609 | -0.155 | 1 | 0.333 |
YANK2 |
0.609 | -0.108 | 2 | 0.349 |
NTRK2 |
0.609 | -0.189 | 3 | 0.471 |
NTRK3 |
0.608 | -0.147 | -1 | 0.656 |
EPHA1 |
0.607 | -0.160 | 3 | 0.478 |
PTK2 |
0.607 | -0.050 | -1 | 0.679 |
LYN |
0.607 | -0.107 | 3 | 0.446 |
EPHA8 |
0.606 | -0.101 | -1 | 0.704 |
EPHA3 |
0.606 | -0.168 | 2 | 0.632 |
CSK |
0.606 | -0.089 | 2 | 0.673 |
FLT4 |
0.605 | -0.178 | 3 | 0.483 |
FGFR4 |
0.603 | -0.091 | -1 | 0.648 |
SYK |
0.603 | -0.073 | -1 | 0.644 |
EPHA5 |
0.603 | -0.137 | 2 | 0.637 |
CK1G2 |
0.602 | -0.106 | -3 | 0.317 |
MUSK |
0.599 | -0.141 | 1 | 0.266 |
IGF1R |
0.598 | -0.125 | 3 | 0.414 |
ERBB4 |
0.597 | -0.090 | 1 | 0.327 |
EPHA2 |
0.594 | -0.133 | -1 | 0.670 |
FES |
0.585 | -0.131 | -1 | 0.606 |
ZAP70 |
0.584 | -0.090 | -1 | 0.583 |