Motif 1199 (n=59)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00458 | IFRD1 | S14 | ochoa | Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) | Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). {ECO:0000250}. |
| O00458 | IFRD1 | S15 | ochoa | Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) | Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). {ECO:0000250}. |
| O15372 | EIF3H | S14 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O15372 | EIF3H | S15 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43707 | ACTN4 | Y13 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O75182 | SIN3B | S11 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| O95197 | RTN3 | S14 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95197 | RTN3 | S15 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95197 | RTN3 | S16 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| P15927 | RPA2 | S11 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P15927 | RPA2 | S12 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P15927 | RPA2 | S13 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P33908 | MAN1A1 | S11 | ochoa | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). |
| P33908 | MAN1A1 | S12 | ochoa|psp | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). |
| P43007 | SLC1A4 | S13 | ochoa | Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) | Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}. |
| P45985 | MAP2K4 | S12 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P49840 | GSK3A | S14 | ochoa | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). {ECO:0000250|UniProtKB:P18265, ECO:0000250|UniProtKB:P49841, ECO:0000250|UniProtKB:Q2NL51, ECO:0000269|PubMed:10868943, ECO:0000269|PubMed:12761548, ECO:0000269|PubMed:17229088, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:30704899, ECO:0000303|PubMed:11749387, ECO:0000303|PubMed:17478001, ECO:0000303|PubMed:19366350}. |
| P78358 | CTAG1A | T12 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
| Q01167 | FOXK2 | S9 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01167 | FOXK2 | T13 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01860 | POU5F1 | S12 | psp | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
| Q12797 | ASPH | S13 | ochoa | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}. |
| Q12797 | ASPH | S14 | ochoa | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}. |
| Q12872 | SFSWAP | S15 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13263 | TRIM28 | S14 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13761 | RUNX3 | T14 | ochoa|psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q15005 | SPCS2 | S11 | ochoa | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}. |
| Q15005 | SPCS2 | S14 | ochoa | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}. |
| Q15056 | EIF4H | Y12 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15056 | EIF4H | S13 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15056 | EIF4H | S14 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q2M2I8 | AAK1 | S14 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q5GH72 | XKR7 | S13 | ochoa | XK-related protein 7 | None |
| Q5T0D9 | TPRG1L | T13 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q5T0D9 | TPRG1L | S14 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q66K64 | DCAF15 | S11 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q6PL24 | TMED8 | S14 | ochoa | Protein TMED8 | None |
| Q7LFL8 | CXXC5 | S14 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7LFL8 | CXXC5 | S15 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7LFL8 | CXXC5 | S16 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q8IZL8 | PELP1 | S13 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8NAF0 | ZNF579 | S12 | ochoa | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q96AE4 | FUBP1 | S11 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96AE4 | FUBP1 | S12 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96AE4 | FUBP1 | S14 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96FZ5 | CMTM7 | S14 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
| Q96S94 | CCNL2 | S13 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
| Q9H2U1 | DHX36 | S17 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H7Z6 | KAT8 | T14 | ochoa | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9NSY1 | BMP2K | S10 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NSY1 | BMP2K | S14 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NYV4 | CDK12 | S14 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P258 | RCC2 | S16 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9UEE5 | STK17A | S12 | ochoa | Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. |
| Q9UEE5 | STK17A | S13 | ochoa | Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. |
| Q9UHB9 | SRP68 | S16 | ochoa | Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| Q9ULI0 | ATAD2B | S14 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9Y4X0 | AMMECR1 | S14 | ochoa | Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein) | None |
| Q9Y4X0 | AMMECR1 | S15 | ochoa | Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.000323 | 3.491 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.011608 | 1.935 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.017363 | 1.760 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.023085 | 1.637 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.028774 | 1.541 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.028774 | 1.541 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.028774 | 1.541 |
| R-HSA-964827 | Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t... | 0.028774 | 1.541 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.045648 | 1.341 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.053977 | 1.268 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.056737 | 1.246 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.059490 | 1.226 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.059490 | 1.226 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.064972 | 1.187 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.075841 | 1.120 |
| R-HSA-72649 | Translation initiation complex formation | 0.014286 | 1.845 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.015167 | 1.819 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.097211 | 1.012 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.112920 | 0.947 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.128361 | 0.892 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.160920 | 0.793 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.163375 | 0.787 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.170697 | 0.768 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.097211 | 1.012 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.130909 | 0.883 |
| R-HSA-73893 | DNA Damage Bypass | 0.153514 | 0.814 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.083912 | 1.076 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.053977 | 1.268 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.047416 | 1.324 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.051208 | 1.291 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.062235 | 1.206 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.067701 | 1.169 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.091914 | 1.037 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.045648 | 1.341 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.175543 | 0.756 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.025934 | 1.586 |
| R-HSA-8849473 | PTK6 Expression | 0.028774 | 1.541 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.073135 | 1.136 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.107713 | 0.968 |
| R-HSA-373752 | Netrin-1 signaling | 0.141028 | 0.851 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.020228 | 1.694 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.028774 | 1.541 |
| R-HSA-964739 | N-glycan trimming and elongation in the cis-Golgi | 0.051208 | 1.291 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.022482 | 1.648 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.045648 | 1.341 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.016071 | 1.794 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.135983 | 0.867 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.002296 | 2.639 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.107713 | 0.968 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.055466 | 1.256 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.053977 | 1.268 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.091914 | 1.037 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.055466 | 1.256 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.034431 | 1.463 |
| R-HSA-912446 | Meiotic recombination | 0.158459 | 0.800 |
| R-HSA-376172 | DSCAM interactions | 0.011608 | 1.935 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.005053 | 2.296 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.027439 | 1.562 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.146044 | 0.836 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.048128 | 1.318 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.048128 | 1.318 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.089254 | 1.049 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.073135 | 1.136 |
| R-HSA-9834899 | Specification of the neural plate border | 0.067701 | 1.169 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.028774 | 1.541 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.112920 | 0.947 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.062235 | 1.206 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.062235 | 1.206 |
| R-HSA-69190 | DNA strand elongation | 0.105099 | 0.978 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.128361 | 0.892 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.133449 | 0.875 |
| R-HSA-9945266 | Differentiation of T cells | 0.056737 | 1.246 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.056737 | 1.246 |
| R-HSA-5358508 | Mismatch Repair | 0.064972 | 1.187 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.133449 | 0.875 |
| R-HSA-9635465 | Suppression of apoptosis | 0.040055 | 1.397 |
| R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... | 0.059490 | 1.226 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.115512 | 0.937 |
| R-HSA-3371511 | HSF1 activation | 0.118096 | 0.928 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.163375 | 0.787 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.194706 | 0.711 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.130909 | 0.883 |
| R-HSA-1474165 | Reproduction | 0.008978 | 2.047 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.135983 | 0.867 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.143539 | 0.843 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.051208 | 1.291 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.064972 | 1.187 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.073135 | 1.136 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.125806 | 0.900 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.017744 | 1.751 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.177956 | 0.750 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.045648 | 1.341 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.048432 | 1.315 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.112920 | 0.947 |
| R-HSA-180786 | Extension of Telomeres | 0.177956 | 0.750 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.001937 | 2.713 |
| R-HSA-72766 | Translation | 0.042017 | 1.377 |
| R-HSA-9629569 | Protein hydroxylation | 0.070422 | 1.152 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.123243 | 0.909 |
| R-HSA-9758941 | Gastrulation | 0.085607 | 1.067 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.048845 | 1.311 |
| R-HSA-450294 | MAP kinase activation | 0.182761 | 0.738 |
| R-HSA-69306 | DNA Replication | 0.089113 | 1.050 |
| R-HSA-373753 | Nephrin family interactions | 0.070422 | 1.152 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.175543 | 0.756 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.091914 | 1.037 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.067701 | 1.169 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.110320 | 0.957 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.053977 | 1.268 |
| R-HSA-5578775 | Ion homeostasis | 0.170697 | 0.768 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.081230 | 1.090 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.062235 | 1.206 |
| R-HSA-69206 | G1/S Transition | 0.063172 | 1.199 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.125806 | 0.900 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.187538 | 0.727 |
| R-HSA-8848021 | Signaling by PTK6 | 0.187538 | 0.727 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.115512 | 0.937 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.138509 | 0.859 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.073694 | 1.133 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.083007 | 1.081 |
| R-HSA-9675135 | Diseases of DNA repair | 0.146044 | 0.836 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.133449 | 0.875 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.031571 | 1.501 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.035296 | 1.452 |
| R-HSA-8939211 | ESR-mediated signaling | 0.172672 | 0.763 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.160920 | 0.793 |
| R-HSA-2262752 | Cellular responses to stress | 0.184598 | 0.734 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.076198 | 1.118 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.197011 | 0.706 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.197011 | 0.706 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.199363 | 0.700 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.204045 | 0.690 |
| R-HSA-448424 | Interleukin-17 signaling | 0.204045 | 0.690 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.204045 | 0.690 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.206376 | 0.685 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.208701 | 0.680 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.213329 | 0.671 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.215634 | 0.666 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.217932 | 0.662 |
| R-HSA-5689603 | UCH proteinases | 0.217932 | 0.662 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.220223 | 0.657 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.222508 | 0.653 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.222508 | 0.653 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.229323 | 0.640 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.233834 | 0.631 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.236079 | 0.627 |
| R-HSA-1500620 | Meiosis | 0.238319 | 0.623 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.238319 | 0.623 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.240551 | 0.619 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.240551 | 0.619 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.242778 | 0.615 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.242778 | 0.615 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.244830 | 0.611 |
| R-HSA-73884 | Base Excision Repair | 0.251620 | 0.599 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.252067 | 0.598 |
| R-HSA-1500931 | Cell-Cell communication | 0.257047 | 0.590 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.258185 | 0.588 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.266851 | 0.574 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.271147 | 0.567 |
| R-HSA-157579 | Telomere Maintenance | 0.271147 | 0.567 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.273285 | 0.563 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.273285 | 0.563 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.273285 | 0.563 |
| R-HSA-3214847 | HATs acetylate histones | 0.275418 | 0.560 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.277544 | 0.557 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.279664 | 0.553 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.281778 | 0.550 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.281778 | 0.550 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.281778 | 0.550 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.285988 | 0.544 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.290174 | 0.537 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.290174 | 0.537 |
| R-HSA-69239 | Synthesis of DNA | 0.294336 | 0.531 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.296408 | 0.528 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.296408 | 0.528 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.298474 | 0.525 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.298474 | 0.525 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.300534 | 0.522 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.300534 | 0.522 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.304637 | 0.516 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.306679 | 0.513 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.308013 | 0.511 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.308716 | 0.510 |
| R-HSA-199991 | Membrane Trafficking | 0.310185 | 0.508 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.312771 | 0.505 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.318811 | 0.496 |
| R-HSA-5693538 | Homology Directed Repair | 0.320812 | 0.494 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.320812 | 0.494 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.322808 | 0.491 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.322808 | 0.491 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.326783 | 0.486 |
| R-HSA-73886 | Chromosome Maintenance | 0.326783 | 0.486 |
| R-HSA-3371556 | Cellular response to heat stress | 0.326783 | 0.486 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.326783 | 0.486 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.328761 | 0.483 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.328761 | 0.483 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.338146 | 0.471 |
| R-HSA-69481 | G2/M Checkpoints | 0.340514 | 0.468 |
| R-HSA-114608 | Platelet degranulation | 0.340514 | 0.468 |
| R-HSA-5576891 | Cardiac conduction | 0.350155 | 0.456 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.353972 | 0.451 |
| R-HSA-1640170 | Cell Cycle | 0.358615 | 0.445 |
| R-HSA-74160 | Gene expression (Transcription) | 0.360593 | 0.443 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.363420 | 0.440 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.376419 | 0.424 |
| R-HSA-69242 | S Phase | 0.385546 | 0.414 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.385546 | 0.414 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.392752 | 0.406 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.394541 | 0.404 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.396325 | 0.402 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.401644 | 0.396 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.406918 | 0.390 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.413880 | 0.383 |
| R-HSA-392499 | Metabolism of proteins | 0.415907 | 0.381 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.416731 | 0.380 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.425870 | 0.371 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.430935 | 0.366 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.430935 | 0.366 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.434287 | 0.362 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.438278 | 0.358 |
| R-HSA-2559583 | Cellular Senescence | 0.442583 | 0.354 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.447504 | 0.349 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.455610 | 0.341 |
| R-HSA-983712 | Ion channel transport | 0.457218 | 0.340 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.460418 | 0.337 |
| R-HSA-68877 | Mitotic Prometaphase | 0.463600 | 0.334 |
| R-HSA-9609690 | HCMV Early Events | 0.468339 | 0.329 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.468339 | 0.329 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.474594 | 0.324 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.477694 | 0.321 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.479238 | 0.319 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.479238 | 0.319 |
| R-HSA-212436 | Generic Transcription Pathway | 0.490794 | 0.309 |
| R-HSA-397014 | Muscle contraction | 0.494429 | 0.306 |
| R-HSA-68882 | Mitotic Anaphase | 0.500383 | 0.301 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.501861 | 0.299 |
| R-HSA-418990 | Adherens junctions interactions | 0.503334 | 0.298 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.514970 | 0.288 |
| R-HSA-72312 | rRNA processing | 0.523521 | 0.281 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.526338 | 0.279 |
| R-HSA-4839726 | Chromatin organization | 0.546956 | 0.262 |
| R-HSA-9609646 | HCMV Infection | 0.548298 | 0.261 |
| R-HSA-421270 | Cell-cell junction organization | 0.549637 | 0.260 |
| R-HSA-5688426 | Deubiquitination | 0.554954 | 0.256 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.570470 | 0.244 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.571814 | 0.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.579382 | 0.237 |
| R-HSA-446728 | Cell junction organization | 0.584355 | 0.233 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.604856 | 0.218 |
| R-HSA-195721 | Signaling by WNT | 0.608370 | 0.216 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.656521 | 0.183 |
| R-HSA-9824446 | Viral Infection Pathways | 0.660484 | 0.180 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.663627 | 0.178 |
| R-HSA-73894 | DNA Repair | 0.674504 | 0.171 |
| R-HSA-1266738 | Developmental Biology | 0.695780 | 0.158 |
| R-HSA-68886 | M Phase | 0.696146 | 0.157 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.709495 | 0.149 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.730479 | 0.136 |
| R-HSA-597592 | Post-translational protein modification | 0.736406 | 0.133 |
| R-HSA-5663205 | Infectious disease | 0.750237 | 0.125 |
| R-HSA-112316 | Neuronal System | 0.765282 | 0.116 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.796290 | 0.099 |
| R-HSA-382551 | Transport of small molecules | 0.798906 | 0.098 |
| R-HSA-422475 | Axon guidance | 0.813947 | 0.089 |
| R-HSA-9679506 | SARS-CoV Infections | 0.819492 | 0.086 |
| R-HSA-9675108 | Nervous system development | 0.833670 | 0.079 |
| R-HSA-449147 | Signaling by Interleukins | 0.854029 | 0.069 |
| R-HSA-162582 | Signal Transduction | 0.902667 | 0.044 |
| R-HSA-109582 | Hemostasis | 0.910214 | 0.041 |
| R-HSA-168249 | Innate Immune System | 0.913483 | 0.039 |
| R-HSA-8953854 | Metabolism of RNA | 0.923255 | 0.035 |
| R-HSA-1643685 | Disease | 0.936690 | 0.028 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.963478 | 0.016 |
| R-HSA-556833 | Metabolism of lipids | 0.990192 | 0.004 |
| R-HSA-168256 | Immune System | 0.998595 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999996 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.714 | 0.199 | 1 | 0.548 |
KIS |
0.708 | 0.183 | 1 | 0.549 |
CDK18 |
0.708 | 0.207 | 1 | 0.558 |
HIPK2 |
0.707 | 0.189 | 1 | 0.510 |
HIPK4 |
0.705 | 0.179 | 1 | 0.481 |
CLK2 |
0.704 | 0.187 | -3 | 0.643 |
MTOR |
0.702 | 0.232 | 1 | 0.448 |
CDK1 |
0.700 | 0.164 | 1 | 0.558 |
DYRK2 |
0.699 | 0.178 | 1 | 0.524 |
P38G |
0.697 | 0.175 | 1 | 0.526 |
JNK2 |
0.697 | 0.189 | 1 | 0.534 |
COT |
0.696 | 0.172 | 2 | 0.530 |
P38B |
0.695 | 0.177 | 1 | 0.583 |
CDK3 |
0.695 | 0.145 | 1 | 0.547 |
CDC7 |
0.695 | 0.136 | 1 | 0.447 |
MOS |
0.695 | 0.198 | 1 | 0.468 |
CDK19 |
0.694 | 0.158 | 1 | 0.524 |
CDK7 |
0.694 | 0.149 | 1 | 0.554 |
DYRK4 |
0.694 | 0.172 | 1 | 0.523 |
NDR2 |
0.693 | 0.139 | -3 | 0.724 |
CDK17 |
0.692 | 0.161 | 1 | 0.530 |
CDK13 |
0.692 | 0.145 | 1 | 0.547 |
ERK1 |
0.692 | 0.149 | 1 | 0.578 |
CDK8 |
0.691 | 0.148 | 1 | 0.524 |
ERK5 |
0.691 | 0.130 | 1 | 0.631 |
HIPK1 |
0.691 | 0.162 | 1 | 0.541 |
P38A |
0.690 | 0.179 | 1 | 0.602 |
CDK5 |
0.690 | 0.164 | 1 | 0.571 |
CDK12 |
0.690 | 0.150 | 1 | 0.530 |
PIM3 |
0.690 | 0.122 | -3 | 0.720 |
JNK3 |
0.689 | 0.163 | 1 | 0.540 |
GSK3A |
0.688 | 0.155 | 4 | 0.490 |
GRK1 |
0.688 | 0.141 | -2 | 0.630 |
P38D |
0.688 | 0.170 | 1 | 0.519 |
MAK |
0.688 | 0.193 | -2 | 0.690 |
AURC |
0.686 | 0.112 | -2 | 0.578 |
SRPK1 |
0.686 | 0.081 | -3 | 0.650 |
SKMLCK |
0.685 | 0.130 | -2 | 0.773 |
ICK |
0.683 | 0.115 | -3 | 0.716 |
GRK7 |
0.683 | 0.118 | 1 | 0.432 |
NLK |
0.683 | 0.102 | 1 | 0.541 |
CDKL5 |
0.683 | 0.087 | -3 | 0.674 |
CDK10 |
0.681 | 0.131 | 1 | 0.569 |
CHAK2 |
0.681 | 0.065 | -1 | 0.592 |
BMPR1B |
0.681 | 0.157 | 1 | 0.506 |
PRPK |
0.680 | 0.069 | -1 | 0.644 |
CDK9 |
0.680 | 0.120 | 1 | 0.552 |
DYRK1B |
0.680 | 0.132 | 1 | 0.547 |
CDK16 |
0.680 | 0.142 | 1 | 0.538 |
CDK14 |
0.680 | 0.150 | 1 | 0.566 |
IKKB |
0.679 | 0.021 | -2 | 0.617 |
IKKA |
0.679 | 0.073 | -2 | 0.618 |
PRP4 |
0.679 | 0.207 | -3 | 0.800 |
JNK1 |
0.678 | 0.139 | 1 | 0.535 |
MST4 |
0.678 | 0.085 | 2 | 0.589 |
PRKD1 |
0.677 | 0.086 | -3 | 0.720 |
CLK4 |
0.676 | 0.095 | -3 | 0.655 |
CDKL1 |
0.676 | 0.052 | -3 | 0.680 |
PIM1 |
0.676 | 0.078 | -3 | 0.678 |
NDR1 |
0.675 | 0.050 | -3 | 0.711 |
NEK6 |
0.675 | 0.047 | -2 | 0.707 |
RSK2 |
0.675 | 0.057 | -3 | 0.653 |
HIPK3 |
0.673 | 0.112 | 1 | 0.523 |
PKACB |
0.672 | 0.077 | -2 | 0.585 |
GSK3B |
0.672 | 0.097 | 4 | 0.488 |
DYRK1A |
0.672 | 0.101 | 1 | 0.525 |
DYRK3 |
0.672 | 0.116 | 1 | 0.513 |
PDHK4 |
0.672 | -0.060 | 1 | 0.412 |
ATR |
0.672 | -0.019 | 1 | 0.384 |
GRK5 |
0.671 | 0.010 | -3 | 0.736 |
MPSK1 |
0.671 | 0.231 | 1 | 0.527 |
GCN2 |
0.671 | -0.025 | 2 | 0.524 |
RAF1 |
0.670 | -0.047 | 1 | 0.383 |
PRKX |
0.670 | 0.078 | -3 | 0.590 |
PKACG |
0.670 | 0.033 | -2 | 0.633 |
MASTL |
0.669 | 0.010 | -2 | 0.679 |
PRKD2 |
0.669 | 0.040 | -3 | 0.662 |
CAMK1B |
0.668 | -0.013 | -3 | 0.720 |
CAMK2G |
0.668 | -0.044 | 2 | 0.509 |
CLK1 |
0.668 | 0.080 | -3 | 0.626 |
PASK |
0.668 | 0.118 | -3 | 0.747 |
CK1E |
0.668 | 0.110 | -3 | 0.597 |
ERK2 |
0.668 | 0.077 | 1 | 0.565 |
RSK4 |
0.667 | 0.059 | -3 | 0.630 |
MLK2 |
0.667 | 0.015 | 2 | 0.522 |
BMPR2 |
0.667 | -0.048 | -2 | 0.690 |
DAPK2 |
0.667 | 0.040 | -3 | 0.734 |
P90RSK |
0.667 | 0.025 | -3 | 0.663 |
TBK1 |
0.666 | -0.095 | 1 | 0.306 |
CDK2 |
0.666 | 0.063 | 1 | 0.564 |
PAK1 |
0.666 | 0.020 | -2 | 0.680 |
MOK |
0.666 | 0.135 | 1 | 0.574 |
WNK1 |
0.666 | -0.008 | -2 | 0.800 |
RSK3 |
0.665 | 0.029 | -3 | 0.652 |
CAMLCK |
0.665 | 0.010 | -2 | 0.718 |
DSTYK |
0.665 | -0.038 | 2 | 0.568 |
GAK |
0.665 | 0.286 | 1 | 0.604 |
IKKE |
0.665 | -0.101 | 1 | 0.289 |
RIPK3 |
0.665 | -0.045 | 3 | 0.450 |
GRK6 |
0.664 | 0.005 | 1 | 0.429 |
MST3 |
0.664 | 0.103 | 2 | 0.570 |
SRPK2 |
0.664 | 0.032 | -3 | 0.573 |
P70S6KB |
0.664 | 0.010 | -3 | 0.664 |
TGFBR1 |
0.663 | 0.065 | -2 | 0.571 |
CAMK2D |
0.663 | 0.006 | -3 | 0.712 |
AURA |
0.662 | 0.057 | -2 | 0.553 |
TLK2 |
0.662 | 0.036 | 1 | 0.291 |
MLK1 |
0.662 | -0.074 | 2 | 0.496 |
MSK1 |
0.662 | 0.038 | -3 | 0.645 |
DRAK1 |
0.662 | 0.090 | 1 | 0.477 |
NIK |
0.662 | -0.056 | -3 | 0.742 |
NEK7 |
0.661 | -0.067 | -3 | 0.721 |
LATS2 |
0.661 | 0.009 | -5 | 0.701 |
SRPK3 |
0.661 | 0.015 | -3 | 0.618 |
PDHK1 |
0.661 | -0.110 | 1 | 0.370 |
CAMK2A |
0.661 | 0.012 | 2 | 0.529 |
NUAK2 |
0.661 | -0.015 | -3 | 0.722 |
CAMK2B |
0.660 | 0.009 | 2 | 0.503 |
NEK9 |
0.660 | -0.040 | 2 | 0.534 |
BCKDK |
0.660 | -0.059 | -1 | 0.607 |
GRK2 |
0.660 | 0.072 | -2 | 0.577 |
ULK2 |
0.660 | -0.086 | 2 | 0.467 |
NIM1 |
0.660 | 0.015 | 3 | 0.448 |
FAM20C |
0.660 | -0.010 | 2 | 0.327 |
MARK4 |
0.659 | -0.003 | 4 | 0.542 |
GRK4 |
0.659 | -0.046 | -2 | 0.652 |
LATS1 |
0.659 | 0.038 | -3 | 0.731 |
CK2A2 |
0.659 | 0.053 | 1 | 0.446 |
CK1D |
0.659 | 0.100 | -3 | 0.552 |
PKCZ |
0.659 | -0.006 | 2 | 0.467 |
TAO3 |
0.659 | 0.089 | 1 | 0.375 |
MLK3 |
0.659 | -0.042 | 2 | 0.436 |
PKCB |
0.659 | 0.003 | 2 | 0.421 |
CK1A2 |
0.659 | 0.097 | -3 | 0.555 |
MNK2 |
0.659 | 0.023 | -2 | 0.702 |
AKT2 |
0.659 | 0.040 | -3 | 0.586 |
PKCA |
0.658 | 0.020 | 2 | 0.420 |
DLK |
0.658 | -0.063 | 1 | 0.393 |
PKN2 |
0.658 | -0.023 | -3 | 0.717 |
DNAPK |
0.658 | -0.017 | 1 | 0.266 |
ACVR2B |
0.657 | 0.062 | -2 | 0.561 |
CK2A1 |
0.657 | 0.065 | 1 | 0.437 |
CDK6 |
0.657 | 0.088 | 1 | 0.561 |
BMPR1A |
0.657 | 0.080 | 1 | 0.462 |
AURB |
0.657 | 0.034 | -2 | 0.573 |
PBK |
0.657 | 0.227 | 1 | 0.608 |
MAPKAPK2 |
0.657 | 0.015 | -3 | 0.622 |
MSK2 |
0.656 | -0.002 | -3 | 0.648 |
VRK2 |
0.656 | 0.056 | 1 | 0.445 |
PKR |
0.656 | 0.030 | 1 | 0.396 |
PKCD |
0.656 | -0.015 | 2 | 0.449 |
ALK4 |
0.656 | -0.001 | -2 | 0.606 |
SGK3 |
0.656 | 0.033 | -3 | 0.661 |
HUNK |
0.656 | -0.094 | 2 | 0.538 |
ERK7 |
0.656 | 0.025 | 2 | 0.306 |
SMG1 |
0.655 | -0.050 | 1 | 0.340 |
PKCG |
0.655 | -0.010 | 2 | 0.424 |
PKN3 |
0.654 | -0.054 | -3 | 0.706 |
GRK3 |
0.654 | 0.078 | -2 | 0.542 |
PAK3 |
0.654 | -0.037 | -2 | 0.670 |
CK1G1 |
0.654 | 0.066 | -3 | 0.566 |
RIPK1 |
0.654 | -0.097 | 1 | 0.377 |
PAK6 |
0.654 | 0.025 | -2 | 0.621 |
DCAMKL1 |
0.653 | 0.021 | -3 | 0.680 |
AMPKA1 |
0.653 | -0.054 | -3 | 0.734 |
LKB1 |
0.652 | 0.088 | -3 | 0.753 |
ACVR2A |
0.652 | 0.030 | -2 | 0.548 |
MEK1 |
0.652 | -0.029 | 2 | 0.548 |
CDK4 |
0.652 | 0.081 | 1 | 0.518 |
YSK4 |
0.651 | -0.054 | 1 | 0.337 |
TGFBR2 |
0.651 | -0.072 | -2 | 0.562 |
ANKRD3 |
0.651 | -0.114 | 1 | 0.410 |
MAPKAPK3 |
0.651 | -0.034 | -3 | 0.666 |
IRE1 |
0.649 | -0.097 | 1 | 0.381 |
PIM2 |
0.649 | 0.029 | -3 | 0.623 |
TTBK2 |
0.649 | -0.120 | 2 | 0.440 |
PAK2 |
0.649 | -0.044 | -2 | 0.663 |
ALK2 |
0.649 | -0.008 | -2 | 0.574 |
PKACA |
0.649 | 0.031 | -2 | 0.543 |
GCK |
0.649 | 0.086 | 1 | 0.393 |
MNK1 |
0.648 | -0.018 | -2 | 0.692 |
AMPKA2 |
0.648 | -0.053 | -3 | 0.700 |
NEK5 |
0.648 | 0.009 | 1 | 0.405 |
QSK |
0.648 | -0.013 | 4 | 0.507 |
CK1A |
0.648 | 0.119 | -3 | 0.482 |
MLK4 |
0.647 | -0.082 | 2 | 0.407 |
PKG2 |
0.647 | -0.003 | -2 | 0.581 |
PLK4 |
0.646 | -0.039 | 2 | 0.373 |
HPK1 |
0.646 | 0.062 | 1 | 0.380 |
ATM |
0.646 | -0.089 | 1 | 0.319 |
PHKG1 |
0.645 | -0.080 | -3 | 0.710 |
MYLK4 |
0.645 | -0.011 | -2 | 0.661 |
PLK1 |
0.645 | -0.076 | -2 | 0.588 |
ULK1 |
0.645 | -0.155 | -3 | 0.684 |
NEK2 |
0.645 | -0.085 | 2 | 0.526 |
MEKK3 |
0.645 | -0.044 | 1 | 0.380 |
TSSK1 |
0.645 | -0.053 | -3 | 0.753 |
NEK11 |
0.644 | -0.020 | 1 | 0.376 |
MEK5 |
0.644 | -0.096 | 2 | 0.526 |
MEKK2 |
0.644 | -0.031 | 2 | 0.492 |
PRKD3 |
0.643 | -0.037 | -3 | 0.631 |
PDK1 |
0.643 | 0.002 | 1 | 0.381 |
CHAK1 |
0.642 | -0.143 | 2 | 0.536 |
WNK3 |
0.641 | -0.234 | 1 | 0.352 |
PKCH |
0.641 | -0.074 | 2 | 0.402 |
WNK4 |
0.641 | -0.041 | -2 | 0.806 |
PINK1 |
0.641 | -0.084 | 1 | 0.507 |
DAPK1 |
0.641 | 0.044 | -3 | 0.675 |
PAK5 |
0.640 | -0.005 | -2 | 0.572 |
SGK1 |
0.640 | 0.038 | -3 | 0.524 |
MEKK1 |
0.640 | -0.071 | 1 | 0.351 |
MARK3 |
0.640 | -0.027 | 4 | 0.460 |
BRSK1 |
0.640 | -0.060 | -3 | 0.674 |
AKT1 |
0.639 | 0.003 | -3 | 0.607 |
ZAK |
0.639 | -0.093 | 1 | 0.328 |
MAP3K15 |
0.639 | 0.017 | 1 | 0.331 |
QIK |
0.639 | -0.091 | -3 | 0.701 |
PAK4 |
0.638 | -0.002 | -2 | 0.577 |
DAPK3 |
0.638 | 0.019 | -3 | 0.683 |
MEKK6 |
0.637 | 0.010 | 1 | 0.382 |
KHS2 |
0.637 | 0.037 | 1 | 0.361 |
TNIK |
0.637 | 0.019 | 3 | 0.526 |
TSSK2 |
0.636 | -0.120 | -5 | 0.749 |
PERK |
0.636 | -0.105 | -2 | 0.610 |
MELK |
0.636 | -0.103 | -3 | 0.677 |
CAMK4 |
0.636 | -0.134 | -3 | 0.691 |
PLK3 |
0.636 | -0.120 | 2 | 0.493 |
PKCE |
0.636 | -0.027 | 2 | 0.419 |
BRSK2 |
0.636 | -0.089 | -3 | 0.689 |
SIK |
0.636 | -0.048 | -3 | 0.634 |
AKT3 |
0.635 | 0.018 | -3 | 0.547 |
PKCT |
0.635 | -0.056 | 2 | 0.408 |
KHS1 |
0.635 | 0.023 | 1 | 0.340 |
PKCI |
0.634 | -0.055 | 2 | 0.431 |
CAMKK2 |
0.634 | -0.066 | -2 | 0.617 |
MINK |
0.633 | 0.004 | 1 | 0.350 |
ROCK2 |
0.633 | 0.038 | -3 | 0.677 |
MAPKAPK5 |
0.633 | -0.101 | -3 | 0.621 |
DCAMKL2 |
0.632 | -0.068 | -3 | 0.680 |
YANK3 |
0.632 | -0.018 | 2 | 0.249 |
TAO2 |
0.632 | -0.074 | 2 | 0.521 |
P70S6K |
0.632 | -0.043 | -3 | 0.588 |
MARK2 |
0.631 | -0.067 | 4 | 0.442 |
HGK |
0.631 | -0.039 | 3 | 0.520 |
MST2 |
0.631 | -0.026 | 1 | 0.372 |
BUB1 |
0.630 | 0.020 | -5 | 0.692 |
NUAK1 |
0.629 | -0.104 | -3 | 0.656 |
BRAF |
0.629 | -0.136 | -4 | 0.695 |
CAMK1G |
0.629 | -0.080 | -3 | 0.632 |
IRAK4 |
0.629 | -0.144 | 1 | 0.367 |
BIKE |
0.629 | 0.180 | 1 | 0.645 |
CAMKK1 |
0.629 | -0.109 | -2 | 0.608 |
NEK4 |
0.629 | -0.090 | 1 | 0.346 |
SMMLCK |
0.629 | -0.053 | -3 | 0.683 |
CHK1 |
0.628 | -0.098 | -3 | 0.695 |
VRK1 |
0.628 | 0.018 | 2 | 0.490 |
AAK1 |
0.628 | 0.219 | 1 | 0.655 |
NEK8 |
0.628 | -0.153 | 2 | 0.505 |
LRRK2 |
0.628 | -0.078 | 2 | 0.543 |
NEK1 |
0.627 | -0.035 | 1 | 0.370 |
OSR1 |
0.627 | 0.021 | 2 | 0.521 |
LOK |
0.627 | -0.077 | -2 | 0.639 |
TAK1 |
0.627 | -0.049 | 1 | 0.347 |
SLK |
0.626 | -0.085 | -2 | 0.598 |
TLK1 |
0.625 | -0.158 | -2 | 0.629 |
IRE2 |
0.625 | -0.191 | 2 | 0.393 |
PLK2 |
0.625 | -0.047 | -3 | 0.678 |
SNRK |
0.625 | -0.187 | 2 | 0.414 |
YSK1 |
0.625 | -0.023 | 2 | 0.524 |
MRCKB |
0.625 | -0.005 | -3 | 0.614 |
STK33 |
0.624 | -0.119 | 2 | 0.385 |
HRI |
0.623 | -0.210 | -2 | 0.644 |
MARK1 |
0.623 | -0.096 | 4 | 0.472 |
MRCKA |
0.623 | -0.016 | -3 | 0.628 |
MYO3B |
0.621 | 0.010 | 2 | 0.534 |
EEF2K |
0.621 | -0.093 | 3 | 0.464 |
HASPIN |
0.621 | -0.031 | -1 | 0.526 |
DMPK1 |
0.620 | 0.021 | -3 | 0.637 |
SBK |
0.620 | -0.001 | -3 | 0.479 |
CRIK |
0.618 | 0.005 | -3 | 0.599 |
PHKG2 |
0.617 | -0.135 | -3 | 0.665 |
TTBK1 |
0.617 | -0.183 | 2 | 0.372 |
CAMK1D |
0.616 | -0.073 | -3 | 0.575 |
NEK3 |
0.615 | -0.041 | 1 | 0.333 |
MEK2 |
0.615 | -0.131 | 2 | 0.524 |
MAP2K4_TYR |
0.615 | 0.274 | -1 | 0.660 |
MST1 |
0.614 | -0.131 | 1 | 0.345 |
PDHK3_TYR |
0.614 | 0.228 | 4 | 0.663 |
CHK2 |
0.613 | -0.051 | -3 | 0.541 |
MAP2K6_TYR |
0.613 | 0.217 | -1 | 0.661 |
PKN1 |
0.612 | -0.085 | -3 | 0.612 |
ASK1 |
0.611 | -0.073 | 1 | 0.321 |
IRAK1 |
0.611 | -0.246 | -1 | 0.551 |
ROCK1 |
0.611 | -0.017 | -3 | 0.636 |
PDHK4_TYR |
0.611 | 0.164 | 2 | 0.598 |
PKMYT1_TYR |
0.610 | 0.225 | 3 | 0.548 |
SSTK |
0.609 | -0.154 | 4 | 0.498 |
BMPR2_TYR |
0.609 | 0.187 | -1 | 0.700 |
TAO1 |
0.609 | -0.084 | 1 | 0.293 |
MYO3A |
0.606 | -0.074 | 1 | 0.325 |
PDHK1_TYR |
0.605 | 0.133 | -1 | 0.645 |
TXK |
0.605 | 0.162 | 1 | 0.500 |
LIMK2_TYR |
0.604 | 0.094 | -3 | 0.749 |
YANK2 |
0.603 | -0.031 | 2 | 0.241 |
TTK |
0.602 | -0.106 | -2 | 0.609 |
CK1G2 |
0.602 | 0.040 | -3 | 0.509 |
PKG1 |
0.601 | -0.060 | -2 | 0.491 |
TESK1_TYR |
0.600 | 0.013 | 3 | 0.547 |
MAP2K7_TYR |
0.600 | 0.012 | 2 | 0.564 |
CK1G3 |
0.599 | 0.021 | -3 | 0.441 |
FGR |
0.599 | 0.105 | 1 | 0.526 |
ALPHAK3 |
0.598 | -0.108 | -1 | 0.574 |
FYN |
0.598 | 0.144 | -1 | 0.613 |
CAMK1A |
0.597 | -0.085 | -3 | 0.545 |
RIPK2 |
0.597 | -0.260 | 1 | 0.295 |
BLK |
0.596 | 0.131 | -1 | 0.604 |
EPHB4 |
0.596 | 0.031 | -1 | 0.598 |
ABL2 |
0.596 | 0.055 | -1 | 0.545 |
ABL1 |
0.595 | 0.059 | -1 | 0.536 |
LCK |
0.594 | 0.119 | -1 | 0.609 |
ITK |
0.592 | 0.073 | -1 | 0.586 |
PTK2 |
0.592 | 0.132 | -1 | 0.647 |
YES1 |
0.592 | 0.034 | -1 | 0.580 |
STLK3 |
0.591 | -0.144 | 1 | 0.287 |
PINK1_TYR |
0.590 | -0.127 | 1 | 0.436 |
TNK2 |
0.588 | -0.007 | 3 | 0.438 |
EPHA6 |
0.588 | -0.006 | -1 | 0.632 |
HCK |
0.588 | 0.050 | -1 | 0.600 |
LIMK1_TYR |
0.588 | -0.072 | 2 | 0.532 |
BMX |
0.585 | 0.032 | -1 | 0.533 |
SRC |
0.584 | 0.068 | -1 | 0.581 |
RET |
0.584 | -0.132 | 1 | 0.353 |
EPHA4 |
0.583 | -0.022 | 2 | 0.513 |
SRMS |
0.583 | -0.003 | 1 | 0.445 |
MERTK |
0.583 | -0.016 | 3 | 0.461 |
MST1R |
0.582 | -0.117 | 3 | 0.490 |
EPHB2 |
0.582 | -0.017 | -1 | 0.575 |
FER |
0.582 | -0.069 | 1 | 0.466 |
EPHB3 |
0.581 | -0.022 | -1 | 0.579 |
TYRO3 |
0.581 | -0.114 | 3 | 0.469 |
CSF1R |
0.580 | -0.097 | 3 | 0.469 |
EPHB1 |
0.580 | -0.048 | 1 | 0.426 |
MET |
0.580 | -0.040 | 3 | 0.465 |
SYK |
0.580 | 0.084 | -1 | 0.600 |
NEK10_TYR |
0.579 | -0.081 | 1 | 0.287 |
JAK3 |
0.579 | -0.093 | 1 | 0.350 |
JAK2 |
0.578 | -0.145 | 1 | 0.348 |
PTK2B |
0.578 | -0.001 | -1 | 0.521 |
ROS1 |
0.578 | -0.133 | 3 | 0.454 |
ZAP70 |
0.577 | 0.055 | -1 | 0.572 |
INSRR |
0.577 | -0.097 | 3 | 0.414 |
DDR1 |
0.577 | -0.173 | 4 | 0.559 |
TNK1 |
0.576 | -0.093 | 3 | 0.485 |
KIT |
0.575 | -0.099 | 3 | 0.465 |
FLT1 |
0.574 | -0.063 | -1 | 0.603 |
KDR |
0.574 | -0.111 | 3 | 0.435 |
TYK2 |
0.574 | -0.199 | 1 | 0.346 |
LYN |
0.574 | -0.010 | 3 | 0.436 |
EPHA7 |
0.573 | -0.049 | 2 | 0.491 |
EPHA8 |
0.573 | -0.022 | -1 | 0.599 |
JAK1 |
0.572 | -0.087 | 1 | 0.305 |
WEE1_TYR |
0.572 | -0.084 | -1 | 0.564 |
EPHA3 |
0.572 | -0.079 | 2 | 0.480 |
FGFR2 |
0.572 | -0.165 | 3 | 0.465 |
PTK6 |
0.569 | -0.116 | -1 | 0.511 |
EPHA5 |
0.569 | -0.057 | 2 | 0.485 |
AXL |
0.568 | -0.133 | 3 | 0.443 |
TNNI3K_TYR |
0.567 | -0.097 | 1 | 0.368 |
NTRK3 |
0.567 | -0.087 | -1 | 0.527 |
TEC |
0.566 | -0.097 | -1 | 0.509 |
FGFR3 |
0.565 | -0.147 | 3 | 0.434 |
BTK |
0.565 | -0.146 | -1 | 0.538 |
NTRK1 |
0.565 | -0.143 | -1 | 0.564 |
EPHA1 |
0.565 | -0.109 | 3 | 0.443 |
ERBB4 |
0.564 | -0.019 | 1 | 0.334 |
LTK |
0.564 | -0.150 | 3 | 0.448 |
CSK |
0.564 | -0.095 | 2 | 0.496 |
EPHA2 |
0.564 | -0.030 | -1 | 0.574 |
ERBB2 |
0.564 | -0.126 | 1 | 0.340 |
DDR2 |
0.563 | -0.110 | 3 | 0.404 |
FGFR1 |
0.563 | -0.196 | 3 | 0.430 |
INSR |
0.562 | -0.133 | 3 | 0.419 |
MATK |
0.562 | -0.087 | -1 | 0.489 |
PDGFRB |
0.562 | -0.230 | 3 | 0.462 |
EGFR |
0.561 | -0.074 | 1 | 0.293 |
FGFR4 |
0.560 | -0.092 | -1 | 0.529 |
FRK |
0.560 | -0.109 | -1 | 0.580 |
TEK |
0.558 | -0.204 | 3 | 0.416 |
ALK |
0.557 | -0.197 | 3 | 0.403 |
FLT3 |
0.556 | -0.244 | 3 | 0.462 |
IGF1R |
0.555 | -0.109 | 3 | 0.379 |
FLT4 |
0.555 | -0.194 | 3 | 0.458 |
NTRK2 |
0.554 | -0.212 | 3 | 0.411 |
FES |
0.552 | -0.064 | -1 | 0.507 |
PDGFRA |
0.552 | -0.285 | 3 | 0.469 |
MUSK |
0.544 | -0.147 | 1 | 0.315 |