Motif 1198 (n=55)

Position-wise Probabilities

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uniprot genes site source protein function
B2RPK0 HMGB1P1 S14 ochoa High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}.
O43760 SYNGR2 S14 ochoa Synaptogyrin-2 (Cellugyrin) May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}.; FUNCTION: (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}.
O60508 CDC40 S14 ochoa Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}.
O60547 GMDS S14 ochoa GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}.
O75122 CLASP2 S14 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75907 DGAT1 S14 ochoa Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q8MK44, ECO:0000250|UniProtKB:Q9Z2A7, ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:18768481, ECO:0000269|PubMed:28420705, ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0000269|PubMed:9756920}.
O94811 TPPP T14 ochoa|psp Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}.
O95238 SPDEF S14 ochoa SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}.
O95295 SNAPIN T14 ochoa SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}.
P08195 SLC3A2 S14 ochoa Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}.
P09429 HMGB1 S14 ochoa High mobility group protein B1 (High mobility group protein 1) (HMG-1) Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}.
P16989 YBX3 T14 ochoa Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.
P26583 HMGB2 S14 ochoa High mobility group protein B2 (High mobility group protein 2) (HMG-2) Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}.
P43243 MATR3 S14 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P49006 MARCKSL1 T14 ochoa MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}.
P52272 HNRNPM T14 ochoa Heterogeneous nuclear ribonucleoprotein M (hnRNP M) Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
P52926 HMGA2 S14 ochoa High mobility group protein HMGI-C (High mobility group AT-hook protein 2) Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.
P60468 SEC61B S14 ochoa Protein transport protein Sec61 subunit beta Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.
P60709 ACTB S14 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62995 TRA2B S14 ochoa Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.
P63261 ACTG1 S14 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
Q01196 RUNX1 T14 ochoa Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.
Q07666 KHDRBS1 S14 ochoa KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.
Q08495 DMTN S14 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q08499 PDE4D S14 ochoa 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}.
Q13595 TRA2A S14 ochoa Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.
Q14061 COX17 S14 ochoa Cytochrome c oxidase copper chaperone Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). {ECO:0000269|PubMed:19393246}.
Q14444 CAPRIN1 S14 ochoa Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}.
Q14562 DHX8 S14 ochoa ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}.
Q15878 CACNA1E S14 ochoa Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3) Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. {ECO:0000269|PubMed:30343943, ECO:0000269|PubMed:7536609}.; FUNCTION: [Isoform 3]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. {ECO:0000269|PubMed:8071363}.
Q63ZY3 KANK2 T14 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q6TDP4 KLHL17 S14 ochoa Kelch-like protein 17 (Actinfilin) Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}.
Q6ZSY5 PPP1R3F S14 ochoa|psp Protein phosphatase 1 regulatory subunit 3F (R3F) Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}.
Q75QN2 INTS8 S14 ochoa Integrator complex subunit 8 (Int8) (Protein kaonashi-1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:28542170, ECO:0000269|PubMed:32966759, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:38570683}.
Q8IY67 RAVER1 S14 ochoa Ribonucleoprotein PTB-binding 1 (Protein raver-1) Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}.
Q96EB6 SIRT1 S14 ochoa|psp NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.
Q96MH2 HEXIM2 S14 ochoa Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.
Q96QD5 DEPDC7 S14 ochoa DEP domain-containing protein 7 (Protein TR2/D15) None
Q96T60 PNKP S14 ochoa Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785}.
Q99640 PKMYT1 T14 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q9GZR2 REXO4 S14 ochoa RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) None
Q9H1K1 ISCU S14 ochoa|psp Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}.
Q9H6Y2 WDR55 S14 ochoa WD repeat-containing protein 55 Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}.
Q9NP87 POLM S14 ochoa DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269|PubMed:12640116, ECO:0000269|PubMed:12888504, ECO:0000269|PubMed:17483519, ECO:0000269|PubMed:17915942}.
Q9NS37 CREBZF S14 ochoa CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}.
Q9UHY1 NRBP1 S14 ochoa Nuclear receptor-binding protein Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}.
Q9UK33 ZNF580 S14 ochoa Zinc finger protein 580 (LDL-induced EC protein) Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}.
Q9UKM7 MAN1B1 S14 ochoa Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1) Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}.
Q9ULW5 RAB26 T14 ochoa Ras-related protein Rab-26 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane (PubMed:23105096). Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (PubMed:20038531). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity). {ECO:0000250|UniProtKB:P51156, ECO:0000250|UniProtKB:P61006, ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}.
Q9UNI6 DUSP12 S14 ochoa Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.
Q9Y210 TRPC6 S14 psp Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}.
Q9Y5L4 TIMM13 S14 ochoa Mitochondrial import inner membrane translocase subunit Tim13 Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.
P62917 RPL8 S14 Sugiyama Large ribosomal subunit protein uL2 (60S ribosomal protein L8) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
O15347 HMGB3 S14 Sugiyama High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}.
Q13164 MAPK7 S14 Sugiyama Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
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reactome_id name p -log10_p
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 0.000119 3.923
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 0.000186 3.731
R-HSA-196025 Formation of annular gap junctions 0.000886 3.052
R-HSA-190873 Gap junction degradation 0.001052 2.978
R-HSA-140342 Apoptosis induced DNA fragmentation 0.001232 2.909
R-HSA-4793950 Defective MAN1B1 causes MRT15 0.015529 1.809
R-HSA-198765 Signalling to ERK5 0.015529 1.809
R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 0.019374 1.713
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 0.027020 1.568
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 0.027020 1.568
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.030821 1.511
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.034608 1.461
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.042137 1.375
R-HSA-390450 Folding of actin by CCT/TriC 0.049608 1.304
R-HSA-112308 Presynaptic depolarization and calcium channel opening 0.053322 1.273
R-HSA-202670 ERKs are inactivated 0.057022 1.244
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.064379 1.191
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.093246 1.030
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.096792 1.014
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.100325 0.999
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.107349 0.969
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.141669 0.849
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.011525 1.938
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.058712 1.231
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.059745 1.224
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.063941 1.194
R-HSA-72163 mRNA Splicing - Major Pathway 0.009818 2.008
R-HSA-192823 Viral mRNA Translation 0.073730 1.132
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.007116 2.148
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.038379 1.416
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.085129 1.070
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.033440 1.476
R-HSA-156902 Peptide chain elongation 0.055651 1.255
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.085129 1.070
R-HSA-9948299 Ribosome-associated quality control 0.123381 0.909
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocy... 0.042137 1.375
R-HSA-6803529 FGFR2 alternative splicing 0.103843 0.984
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.093246 1.030
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.065005 1.187
R-HSA-72172 mRNA Splicing 0.011634 1.934
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.013056 1.884
R-HSA-5674135 MAP2K and MAPK activation 0.015992 1.796
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.134910 0.870
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.080507 1.094
R-HSA-72764 Eukaryotic Translation Termination 0.065005 1.187
R-HSA-9656223 Signaling by RAF1 mutants 0.015992 1.796
R-HSA-198753 ERK/MAPK targets 0.096792 1.014
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.019182 1.717
R-HSA-9649948 Signaling downstream of RAS mutants 0.019182 1.717
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.019182 1.717
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 0.045879 1.338
R-HSA-6802957 Oncogenic MAPK signaling 0.051661 1.287
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.023205 1.634
R-HSA-69478 G2/M DNA replication checkpoint 0.034608 1.461
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.060707 1.217
R-HSA-445095 Interaction between L1 and Ankyrins 0.007549 2.122
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.064379 1.191
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.064379 1.191
R-HSA-72689 Formation of a pool of free 40S subunits 0.065005 1.187
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.029790 1.526
R-HSA-6802949 Signaling by RAS mutants 0.019182 1.717
R-HSA-901032 ER Quality Control Compartment (ERQC) 0.121236 0.916
R-HSA-156842 Eukaryotic Translation Elongation 0.060785 1.216
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 0.027020 1.568
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 0.049608 1.304
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.093246 1.030
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.080507 1.094
R-HSA-8856828 Clathrin-mediated endocytosis 0.131206 0.882
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.148375 0.829
R-HSA-901042 Calnexin/calreticulin cycle 0.148375 0.829
R-HSA-9932451 SWI/SNF chromatin remodelers 0.114319 0.942
R-HSA-9932444 ATP-dependent chromatin remodelers 0.114319 0.942
R-HSA-2408557 Selenocysteine synthesis 0.071515 1.146
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.095814 1.019
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.095814 1.019
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.099457 1.002
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.099457 1.002
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.038379 1.416
R-HSA-8951936 RUNX3 regulates p14-ARF 0.060707 1.217
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.060707 1.217
R-HSA-933542 TRAF6 mediated NF-kB activation 0.110841 0.955
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.128100 0.892
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.074846 1.126
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.127279 0.895
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.060707 1.217
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.125976 0.900
R-HSA-9664417 Leishmania phagocytosis 0.125976 0.900
R-HSA-9664407 Parasite infection 0.125976 0.900
R-HSA-437239 Recycling pathway of L1 0.019849 1.702
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.068036 1.167
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.071679 1.145
R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.082525 1.083
R-HSA-190828 Gap junction trafficking 0.017876 1.748
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.145029 0.839
R-HSA-72613 Eukaryotic Translation Initiation 0.092210 1.035
R-HSA-9764561 Regulation of CDH1 Function 0.027043 1.568
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.137814 0.861
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.009395 2.027
R-HSA-1236974 ER-Phagosome pathway 0.056665 1.247
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.068036 1.167
R-HSA-157858 Gap junction trafficking and regulation 0.021213 1.673
R-HSA-72737 Cap-dependent Translation Initiation 0.092210 1.035
R-HSA-9659379 Sensory processing of sound 0.045883 1.338
R-HSA-6787639 GDP-fucose biosynthesis 0.082525 1.083
R-HSA-3295583 TRP channels 0.117784 0.929
R-HSA-75109 Triglyceride biosynthesis 0.121236 0.916
R-HSA-1268020 Mitochondrial protein import 0.030978 1.509
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.035978 1.444
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.147185 0.832
R-HSA-9711097 Cellular response to starvation 0.151242 0.820
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.040365 1.394
R-HSA-9609507 Protein localization 0.029664 1.528
R-HSA-1482883 Acyl chain remodeling of DAG and TAG 0.064379 1.191
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.026283 1.580
R-HSA-418360 Platelet calcium homeostasis 0.128100 0.892
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.089686 1.047
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.019849 1.702
R-HSA-5223345 Miscellaneous transport and binding events 0.145029 0.839
R-HSA-114508 Effects of PIP2 hydrolysis 0.145029 0.839
R-HSA-8953854 Metabolism of RNA 0.049316 1.307
R-HSA-446353 Cell-extracellular matrix interactions 0.002592 2.586
R-HSA-9629569 Protein hydroxylation 0.093246 1.030
R-HSA-210991 Basigin interactions 0.096792 1.014
R-HSA-9865881 Complex III assembly 0.110841 0.955
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.143152 0.844
R-HSA-373760 L1CAM interactions 0.092210 1.035
R-HSA-8878159 Transcriptional regulation by RUNX3 0.008880 2.052
R-HSA-180024 DARPP-32 events 0.128100 0.892
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.080507 1.094
R-HSA-1236975 Antigen processing-Cross presentation 0.080507 1.094
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.068234 1.166
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.068234 1.166
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.068234 1.166
R-HSA-156711 Polo-like kinase mediated events 0.086112 1.065
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.081655 1.088
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.082808 1.082
R-HSA-166166 MyD88-independent TLR4 cascade 0.082808 1.082
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.077094 1.113
R-HSA-9945266 Differentiation of T cells 0.075308 1.123
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.075308 1.123
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.042175 1.375
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.086297 1.064
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.089831 1.047
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.141669 0.849
R-HSA-9694301 Maturation of replicase proteins 0.038379 1.416
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.039661 1.402
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.039661 1.402
R-HSA-9730414 MITF-M-regulated melanocyte development 0.063444 1.198
R-HSA-9856651 MITF-M-dependent gene expression 0.028361 1.547
R-HSA-376176 Signaling by ROBO receptors 0.056528 1.248
R-HSA-418990 Adherens junctions interactions 0.066713 1.176
R-HSA-446728 Cell junction organization 0.111531 0.953
R-HSA-421270 Cell-cell junction organization 0.090144 1.045
R-HSA-1500931 Cell-Cell communication 0.144551 0.840
R-HSA-5620971 Pyroptosis 0.124674 0.904
R-HSA-422475 Axon guidance 0.006552 2.184
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.052327 1.281
R-HSA-3928662 EPHB-mediated forward signaling 0.017876 1.748
R-HSA-9675108 Nervous system development 0.009123 2.040
R-HSA-2682334 EPH-Ephrin signaling 0.060785 1.216
R-HSA-75153 Apoptotic execution phase 0.019182 1.717
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.103843 0.984
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.091018 1.041
R-HSA-194138 Signaling by VEGF 0.104376 0.981
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.151709 0.819
R-HSA-8853659 RET signaling 0.155030 0.810
R-HSA-109581 Apoptosis 0.156686 0.805
R-HSA-427359 SIRT1 negatively regulates rRNA expression 0.158339 0.800
R-HSA-549127 SLC-mediated transport of organic cations 0.158339 0.800
R-HSA-2408522 Selenoamino acid metabolism 0.159423 0.797
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.164917 0.783
R-HSA-3781860 Diseases associated with N-glycosylation of proteins 0.164917 0.783
R-HSA-5260271 Diseases of Immune System 0.168187 0.774
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.168187 0.774
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 0.168187 0.774
R-HSA-71240 Tryptophan catabolism 0.168187 0.774
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.169069 0.772
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.171445 0.766
R-HSA-9694548 Maturation of spike protein 0.171445 0.766
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.174627 0.758
R-HSA-611105 Respiratory electron transport 0.180215 0.744
R-HSA-168255 Influenza Infection 0.181616 0.741
R-HSA-2559583 Cellular Senescence 0.183020 0.738
R-HSA-373752 Netrin-1 signaling 0.184350 0.734
R-HSA-73894 DNA Repair 0.186261 0.730
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.187545 0.727
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.193898 0.712
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.194302 0.712
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.197057 0.705
R-HSA-168898 Toll-like Receptor Cascades 0.198556 0.702
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.200203 0.699
R-HSA-9864848 Complex IV assembly 0.206459 0.685
R-HSA-72187 mRNA 3'-end processing 0.209569 0.679
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.209569 0.679
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.212667 0.672
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.212667 0.672
R-HSA-5357801 Programmed Cell Death 0.219992 0.658
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.227979 0.642
R-HSA-352230 Amino acid transport across the plasma membrane 0.231006 0.636
R-HSA-8979227 Triglyceride metabolism 0.231006 0.636
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.234021 0.631
R-HSA-8873719 RAB geranylgeranylation 0.234021 0.631
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.234021 0.631
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.235966 0.627
R-HSA-1266738 Developmental Biology 0.236315 0.627
R-HSA-73856 RNA Polymerase II Transcription Termination 0.237025 0.625
R-HSA-450294 MAP kinase activation 0.237025 0.625
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.240017 0.620
R-HSA-9707616 Heme signaling 0.240017 0.620
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.240017 0.620
R-HSA-8848021 Signaling by PTK6 0.242997 0.614
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.242997 0.614
R-HSA-8878171 Transcriptional regulation by RUNX1 0.250309 0.602
R-HSA-9958863 SLC-mediated transport of amino acids 0.254805 0.594
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.257728 0.589
R-HSA-5218859 Regulated Necrosis 0.257728 0.589
R-HSA-72766 Translation 0.257906 0.589
R-HSA-72312 rRNA processing 0.259007 0.587
R-HSA-448424 Interleukin-17 signaling 0.263541 0.579
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.263541 0.579
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.266431 0.574
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.266431 0.574
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.269309 0.570
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.269309 0.570
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.272177 0.565
R-HSA-71403 Citric acid cycle (TCA cycle) 0.277878 0.556
R-HSA-5689603 UCH proteinases 0.280713 0.552
R-HSA-9694635 Translation of Structural Proteins 0.283536 0.547
R-HSA-383280 Nuclear Receptor transcription pathway 0.286349 0.543
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.291941 0.535
R-HSA-5654738 Signaling by FGFR2 0.291941 0.535
R-HSA-69620 Cell Cycle Checkpoints 0.296709 0.528
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.297490 0.527
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.297490 0.527
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.302997 0.519
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.302997 0.519
R-HSA-8953897 Cellular responses to stimuli 0.304680 0.516
R-HSA-416476 G alpha (q) signalling events 0.305386 0.515
R-HSA-141424 Amplification of signal from the kinetochores 0.308461 0.511
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.308461 0.511
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.311177 0.507
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.311177 0.507
R-HSA-390466 Chaperonin-mediated protein folding 0.313882 0.503
R-HSA-73884 Base Excision Repair 0.321937 0.492
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.324601 0.489
R-HSA-9658195 Leishmania infection 0.329866 0.482
R-HSA-9824443 Parasitic Infection Pathways 0.329866 0.482
R-HSA-391251 Protein folding 0.329898 0.482
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.329898 0.482
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.337767 0.471
R-HSA-5673001 RAF/MAP kinase cascade 0.341313 0.467
R-HSA-422356 Regulation of insulin secretion 0.348118 0.458
R-HSA-190236 Signaling by FGFR 0.348118 0.458
R-HSA-3214847 HATs acetylate histones 0.350681 0.455
R-HSA-9614085 FOXO-mediated transcription 0.350681 0.455
R-HSA-5684996 MAPK1/MAPK3 signaling 0.351283 0.454
R-HSA-69618 Mitotic Spindle Checkpoint 0.353234 0.452
R-HSA-9020702 Interleukin-1 signaling 0.355777 0.449
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.358310 0.446
R-HSA-9842860 Regulation of endogenous retroelements 0.358310 0.446
R-HSA-9860931 Response of endothelial cells to shear stress 0.363347 0.440
R-HSA-111885 Opioid Signalling 0.363347 0.440
R-HSA-5696398 Nucleotide Excision Repair 0.368345 0.434
R-HSA-418346 Platelet homeostasis 0.370829 0.431
R-HSA-9692914 SARS-CoV-1-host interactions 0.370829 0.431
R-HSA-2672351 Stimuli-sensing channels 0.375770 0.425
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.378225 0.422
R-HSA-2262752 Cellular responses to stress 0.384198 0.415
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.387954 0.411
R-HSA-212165 Epigenetic regulation of gene expression 0.389243 0.410
R-HSA-9855142 Cellular responses to mechanical stimuli 0.390362 0.409
R-HSA-9679506 SARS-CoV Infections 0.392808 0.406
R-HSA-1474244 Extracellular matrix organization 0.400314 0.398
R-HSA-8878166 Transcriptional regulation by RUNX2 0.406963 0.390
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.411624 0.385
R-HSA-3371556 Cellular response to heat stress 0.411624 0.385
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.414027 0.383
R-HSA-5683057 MAPK family signaling cascades 0.422182 0.374
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.423119 0.374
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.423119 0.374
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.423119 0.374
R-HSA-9694516 SARS-CoV-2 Infection 0.424888 0.372
R-HSA-69481 G2/M Checkpoints 0.427655 0.369
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.429909 0.367
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.438841 0.358
R-HSA-9909396 Circadian clock 0.441053 0.356
R-HSA-9018519 Estrogen-dependent gene expression 0.451981 0.345
R-HSA-163685 Integration of energy metabolism 0.451981 0.345
R-HSA-71291 Metabolism of amino acids and derivatives 0.458769 0.338
R-HSA-9824446 Viral Infection Pathways 0.469685 0.328
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.471170 0.327
R-HSA-166520 Signaling by NTRKs 0.479422 0.319
R-HSA-446652 Interleukin-1 family signaling 0.487589 0.312
R-HSA-425407 SLC-mediated transmembrane transport 0.489074 0.311
R-HSA-199991 Membrane Trafficking 0.489188 0.311
R-HSA-5693532 DNA Double-Strand Break Repair 0.489612 0.310
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.491626 0.308
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.497622 0.303
R-HSA-5663205 Infectious disease 0.510452 0.292
R-HSA-2467813 Separation of Sister Chromatids 0.511344 0.291
R-HSA-73857 RNA Polymerase II Transcription 0.512374 0.290
R-HSA-5619102 SLC transporter disorders 0.517111 0.286
R-HSA-446203 Asparagine N-linked glycosylation 0.520113 0.284
R-HSA-74160 Gene expression (Transcription) 0.524164 0.281
R-HSA-418555 G alpha (s) signalling events 0.526574 0.279
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.534013 0.272
R-HSA-9678108 SARS-CoV-1 Infection 0.534013 0.272
R-HSA-3781865 Diseases of glycosylation 0.550333 0.259
R-HSA-69275 G2/M Transition 0.553883 0.257
R-HSA-382551 Transport of small molecules 0.556676 0.254
R-HSA-453274 Mitotic G2-G2/M phases 0.557405 0.254
R-HSA-983712 Ion channel transport 0.559155 0.252
R-HSA-6798695 Neutrophil degranulation 0.561469 0.251
R-HSA-68877 Mitotic Prometaphase 0.566090 0.247
R-HSA-1483206 Glycerophospholipid biosynthesis 0.582961 0.234
R-HSA-68882 Mitotic Anaphase 0.605501 0.218
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.607064 0.217
R-HSA-388396 GPCR downstream signalling 0.607130 0.217
R-HSA-109582 Hemostasis 0.615713 0.211
R-HSA-168249 Innate Immune System 0.616753 0.210
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.624394 0.205
R-HSA-3247509 Chromatin modifying enzymes 0.632727 0.199
R-HSA-5653656 Vesicle-mediated transport 0.635813 0.197
R-HSA-8939211 ESR-mediated signaling 0.637081 0.196
R-HSA-202733 Cell surface interactions at the vascular wall 0.637081 0.196
R-HSA-157118 Signaling by NOTCH 0.641384 0.193
R-HSA-5619115 Disorders of transmembrane transporters 0.651231 0.186
R-HSA-4839726 Chromatin organization 0.653995 0.184
R-HSA-5688426 Deubiquitination 0.662159 0.179
R-HSA-162582 Signal Transduction 0.667106 0.176
R-HSA-69278 Cell Cycle, Mitotic 0.673899 0.171
R-HSA-372790 Signaling by GPCR 0.674612 0.171
R-HSA-76002 Platelet activation, signaling and aggregation 0.686780 0.163
R-HSA-1483257 Phospholipid metabolism 0.711942 0.148
R-HSA-449147 Signaling by Interleukins 0.724562 0.140
R-HSA-112315 Transmission across Chemical Synapses 0.742419 0.129
R-HSA-212436 Generic Transcription Pathway 0.749064 0.125
R-HSA-9006931 Signaling by Nuclear Receptors 0.780526 0.108
R-HSA-1640170 Cell Cycle 0.784659 0.105
R-HSA-68886 M Phase 0.797442 0.098
R-HSA-597592 Post-translational protein modification 0.799616 0.097
R-HSA-1643685 Disease 0.808348 0.092
R-HSA-418594 G alpha (i) signalling events 0.816791 0.088
R-HSA-5668914 Diseases of metabolism 0.830950 0.080
R-HSA-112316 Neuronal System 0.856694 0.067
R-HSA-392499 Metabolism of proteins 0.856926 0.067
R-HSA-1280218 Adaptive Immune System 0.927180 0.033
R-HSA-1280215 Cytokine Signaling in Immune system 0.933759 0.030
R-HSA-9709957 Sensory Perception 0.962292 0.017
R-HSA-168256 Immune System 0.972485 0.012
R-HSA-1430728 Metabolism 0.995855 0.002
R-HSA-556833 Metabolism of lipids 0.997968 0.001
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.790 0.344 1 0.758
DYRK2DYRK2 0.782 0.345 1 0.776
CLK2CLK2 0.782 0.350 -3 0.669
HIPK4HIPK4 0.782 0.343 1 0.775
HIPK2HIPK2 0.781 0.345 1 0.731
SRPK1SRPK1 0.780 0.277 -3 0.702
HIPK1HIPK1 0.779 0.352 1 0.782
MAKMAK 0.775 0.361 -2 0.725
DYRK4DYRK4 0.774 0.322 1 0.732
CDKL5CDKL5 0.771 0.246 -3 0.723
ICKICK 0.769 0.274 -3 0.745
MOSMOS 0.768 0.187 1 0.713
CDKL1CDKL1 0.767 0.221 -3 0.723
CLK4CLK4 0.767 0.278 -3 0.678
KISKIS 0.767 0.277 1 0.746
PIM3PIM3 0.766 0.199 -3 0.730
DYRK3DYRK3 0.766 0.319 1 0.780
CDK18CDK18 0.764 0.296 1 0.705
COTCOT 0.764 0.121 2 0.705
NLKNLK 0.764 0.218 1 0.762
JNK2JNK2 0.763 0.276 1 0.691
ERK5ERK5 0.763 0.207 1 0.812
PRKD1PRKD1 0.763 0.245 -3 0.730
DYRK1ADYRK1A 0.762 0.285 1 0.747
RSK2RSK2 0.762 0.207 -3 0.692
PIM1PIM1 0.762 0.209 -3 0.680
SKMLCKSKMLCK 0.762 0.219 -2 0.826
CDK5CDK5 0.762 0.267 1 0.754
CLK1CLK1 0.761 0.269 -3 0.647
P38BP38B 0.761 0.271 1 0.735
HIPK3HIPK3 0.760 0.304 1 0.755
CDK3CDK3 0.760 0.258 1 0.681
CDK1CDK1 0.760 0.243 1 0.708
DYRK1BDYRK1B 0.760 0.291 1 0.731
P38AP38A 0.760 0.270 1 0.774
SRPK2SRPK2 0.759 0.213 -3 0.638
MTORMTOR 0.759 0.219 1 0.635
JNK3JNK3 0.759 0.252 1 0.717
CDK7CDK7 0.758 0.245 1 0.740
SRPK3SRPK3 0.758 0.189 -3 0.673
AURCAURC 0.758 0.201 -2 0.682
CAMK1BCAMK1B 0.758 0.144 -3 0.718
CDK8CDK8 0.757 0.230 1 0.731
CDC7CDC7 0.757 0.089 1 0.666
MOKMOK 0.757 0.328 1 0.819
P38GP38G 0.757 0.254 1 0.657
CDK19CDK19 0.757 0.245 1 0.713
CDK13CDK13 0.757 0.240 1 0.719
PRKD2PRKD2 0.757 0.207 -3 0.672
NDR2NDR2 0.757 0.177 -3 0.714
P90RSKP90RSK 0.757 0.184 -3 0.714
CDK12CDK12 0.756 0.255 1 0.696
CAMLCKCAMLCK 0.755 0.166 -2 0.786
PRPKPRPK 0.755 0.026 -1 0.688
PKACBPKACB 0.754 0.221 -2 0.690
P38DP38D 0.754 0.249 1 0.692
DAPK2DAPK2 0.753 0.165 -3 0.729
GSK3AGSK3A 0.753 0.230 4 0.567
CDK14CDK14 0.753 0.268 1 0.718
PRP4PRP4 0.753 0.278 -3 0.781
RSK3RSK3 0.752 0.176 -3 0.690
CDK10CDK10 0.752 0.263 1 0.716
ERK1ERK1 0.751 0.228 1 0.727
CDK17CDK17 0.751 0.245 1 0.657
ATRATR 0.751 0.026 1 0.651
GRK1GRK1 0.751 0.096 -2 0.735
RSK4RSK4 0.750 0.187 -3 0.676
AKT2AKT2 0.750 0.196 -3 0.624
PKACGPKACG 0.749 0.164 -2 0.729
MPSK1MPSK1 0.748 0.274 1 0.731
NDR1NDR1 0.748 0.127 -3 0.700
NUAK2NUAK2 0.748 0.115 -3 0.706
PKN3PKN3 0.747 0.077 -3 0.710
CDK9CDK9 0.747 0.225 1 0.721
NIKNIK 0.747 0.069 -3 0.710
LATS1LATS1 0.747 0.144 -3 0.732
PRKXPRKX 0.747 0.220 -3 0.600
MAPKAPK2MAPKAPK2 0.747 0.141 -3 0.643
CAMK2GCAMK2G 0.746 -0.001 2 0.748
CAMK2DCAMK2D 0.746 0.109 -3 0.696
MST4MST4 0.746 0.117 2 0.704
BMPR2BMPR2 0.746 -0.098 -2 0.754
BMPR1BBMPR1B 0.746 0.081 1 0.644
WNK1WNK1 0.746 0.056 -2 0.793
PKCDPKCD 0.745 0.119 2 0.635
CHAK2CHAK2 0.745 0.038 -1 0.623
CAMK2ACAMK2A 0.745 0.135 2 0.736
P70S6KBP70S6KB 0.745 0.123 -3 0.677
CDK16CDK16 0.744 0.242 1 0.675
GRK7GRK7 0.744 0.094 1 0.587
PAK1PAK1 0.744 0.132 -2 0.748
PIM2PIM2 0.743 0.173 -3 0.655
AMPKA1AMPKA1 0.743 0.102 -3 0.703
MAPKAPK3MAPKAPK3 0.743 0.109 -3 0.663
MSK1MSK1 0.743 0.169 -3 0.668
CAMK2BCAMK2B 0.742 0.113 2 0.730
MNK2MNK2 0.742 0.138 -2 0.754
TSSK2TSSK2 0.742 0.085 -5 0.760
PRKD3PRKD3 0.741 0.140 -3 0.654
AURBAURB 0.741 0.143 -2 0.670
SGK3SGK3 0.741 0.176 -3 0.657
JNK1JNK1 0.741 0.208 1 0.684
PDHK4PDHK4 0.740 -0.136 1 0.648
GSK3BGSK3B 0.740 0.157 4 0.561
MARK4MARK4 0.740 0.087 4 0.677
AMPKA2AMPKA2 0.740 0.114 -3 0.680
PKG2PKG2 0.739 0.148 -2 0.684
PKN2PKN2 0.739 0.066 -3 0.681
NEK6NEK6 0.739 -0.015 -2 0.753
MNK1MNK1 0.739 0.121 -2 0.763
TSSK1TSSK1 0.739 0.102 -3 0.722
MSK2MSK2 0.739 0.133 -3 0.683
RAF1RAF1 0.738 -0.104 1 0.608
PKCBPKCB 0.738 0.106 2 0.560
DCAMKL1DCAMKL1 0.738 0.138 -3 0.669
GRK5GRK5 0.738 -0.086 -3 0.686
TGFBR1TGFBR1 0.738 0.036 -2 0.692
FAM20CFAM20C 0.737 0.105 2 0.608
LATS2LATS2 0.737 0.058 -5 0.624
RIPK3RIPK3 0.737 -0.057 3 0.562
PKCAPKCA 0.737 0.113 2 0.573
AURAAURA 0.737 0.129 -2 0.649
VRK2VRK2 0.736 0.039 1 0.713
DSTYKDSTYK 0.736 -0.092 2 0.721
MASTLMASTL 0.736 -0.050 -2 0.694
CDK2CDK2 0.736 0.149 1 0.730
IKKBIKKB 0.736 -0.090 -2 0.608
PKACAPKACA 0.736 0.184 -2 0.647
PKCGPKCG 0.735 0.090 2 0.592
TGFBR2TGFBR2 0.735 -0.045 -2 0.706
PAK3PAK3 0.735 0.083 -2 0.731
GCN2GCN2 0.735 -0.109 2 0.650
PKRPKR 0.735 0.021 1 0.661
ERK2ERK2 0.735 0.162 1 0.725
ALK4ALK4 0.735 -0.014 -2 0.716
MLK2MLK2 0.734 -0.036 2 0.640
MYLK4MYLK4 0.734 0.107 -2 0.747
SGK1SGK1 0.734 0.202 -3 0.573
PASKPASK 0.734 0.102 -3 0.746
ULK2ULK2 0.734 -0.116 2 0.623
NIM1NIM1 0.733 0.116 3 0.594
PKCZPKCZ 0.733 0.064 2 0.606
MLK1MLK1 0.733 -0.122 2 0.635
GRK6GRK6 0.732 -0.066 1 0.626
AKT1AKT1 0.732 0.164 -3 0.626
TBK1TBK1 0.731 -0.132 1 0.499
MLK3MLK3 0.731 -0.037 2 0.592
DNAPKDNAPK 0.731 0.056 1 0.503
ALK2ALK2 0.731 0.002 -2 0.707
IRE1IRE1 0.731 -0.029 1 0.637
ERK7ERK7 0.731 0.086 2 0.431
AKT3AKT3 0.730 0.189 -3 0.596
ATMATM 0.730 -0.028 1 0.587
PAK2PAK2 0.730 0.063 -2 0.727
CDK6CDK6 0.729 0.197 1 0.714
CK1ECK1E 0.729 0.032 -3 0.467
BUB1BUB1 0.729 0.173 -5 0.680
RIPK1RIPK1 0.729 -0.098 1 0.616
MST3MST3 0.728 0.088 2 0.667
PDHK1PDHK1 0.728 -0.219 1 0.623
QSKQSK 0.728 0.095 4 0.645
NEK7NEK7 0.728 -0.164 -3 0.695
TLK2TLK2 0.728 -0.030 1 0.592
NEK9NEK9 0.728 -0.115 2 0.649
DAPK3DAPK3 0.728 0.141 -3 0.683
IKKEIKKE 0.728 -0.145 1 0.491
CDK4CDK4 0.727 0.202 1 0.691
SBKSBK 0.727 0.189 -3 0.534
DAPK1DAPK1 0.727 0.146 -3 0.679
DLKDLK 0.727 -0.189 1 0.613
SMG1SMG1 0.726 -0.035 1 0.612
GAKGAK 0.726 0.134 1 0.753
HUNKHUNK 0.726 -0.118 2 0.636
PKCEPKCE 0.726 0.123 2 0.576
ACVR2BACVR2B 0.725 -0.027 -2 0.684
ROCK2ROCK2 0.725 0.174 -3 0.668
PKCHPKCH 0.725 0.040 2 0.552
ANKRD3ANKRD3 0.725 -0.186 1 0.651
MEK1MEK1 0.725 -0.116 2 0.683
SMMLCKSMMLCK 0.724 0.086 -3 0.688
IKKAIKKA 0.724 -0.071 -2 0.604
CAMK4CAMK4 0.724 -0.016 -3 0.657
CK1DCK1D 0.724 0.032 -3 0.419
LKB1LKB1 0.723 0.092 -3 0.690
MELKMELK 0.723 0.023 -3 0.665
PBKPBK 0.723 0.183 1 0.725
CAMK1GCAMK1G 0.723 0.067 -3 0.647
GRK4GRK4 0.723 -0.119 -2 0.742
ACVR2AACVR2A 0.723 -0.051 -2 0.667
PLK1PLK1 0.723 -0.092 -2 0.698
NEK2NEK2 0.722 -0.060 2 0.635
IRE2IRE2 0.722 -0.059 2 0.598
TTBK2TTBK2 0.721 -0.136 2 0.592
BMPR1ABMPR1A 0.721 0.006 1 0.614
DCAMKL2DCAMKL2 0.721 0.042 -3 0.670
CHK1CHK1 0.721 0.008 -3 0.663
NEK5NEK5 0.721 -0.035 1 0.642
DMPK1DMPK1 0.720 0.177 -3 0.637
SSTKSSTK 0.720 0.044 4 0.640
CAMK1DCAMK1D 0.720 0.102 -3 0.589
TAO3TAO3 0.720 0.031 1 0.579
PHKG1PHKG1 0.720 -0.010 -3 0.687
WNK4WNK4 0.720 -0.020 -2 0.778
CK1A2CK1A2 0.720 0.018 -3 0.420
QIKQIK 0.720 0.013 -3 0.681
YSK4YSK4 0.720 -0.130 1 0.542
MRCKBMRCKB 0.719 0.142 -3 0.623
MARK3MARK3 0.719 0.042 4 0.598
WNK3WNK3 0.718 -0.229 1 0.600
PKCIPKCI 0.718 0.059 2 0.584
MEKK2MEKK2 0.718 -0.061 2 0.625
BRSK1BRSK1 0.718 0.029 -3 0.669
SIKSIK 0.718 0.076 -3 0.644
PINK1PINK1 0.718 -0.062 1 0.755
GRK2GRK2 0.718 -0.060 -2 0.631
PDK1PDK1 0.718 0.030 1 0.594
NUAK1NUAK1 0.717 0.017 -3 0.653
PKCTPKCT 0.717 0.068 2 0.559
DRAK1DRAK1 0.717 -0.047 1 0.561
PERKPERK 0.717 -0.116 -2 0.710
MEK5MEK5 0.717 -0.149 2 0.649
TNIKTNIK 0.717 0.082 3 0.749
PAK6PAK6 0.716 0.053 -2 0.661
MLK4MLK4 0.716 -0.128 2 0.560
ULK1ULK1 0.716 -0.205 -3 0.662
MRCKAMRCKA 0.716 0.126 -3 0.630
TLK1TLK1 0.716 -0.101 -2 0.735
CHAK1CHAK1 0.716 -0.127 2 0.628
PLK3PLK3 0.716 -0.093 2 0.684
P70S6KP70S6K 0.715 0.079 -3 0.619
PLK4PLK4 0.715 -0.041 2 0.511
BCKDKBCKDK 0.715 -0.165 -1 0.597
GCKGCK 0.714 0.035 1 0.569
CRIKCRIK 0.714 0.163 -3 0.638
MAPKAPK5MAPKAPK5 0.714 0.007 -3 0.641
MEKK1MEKK1 0.713 -0.128 1 0.601
HPK1HPK1 0.713 0.050 1 0.546
MEKK3MEKK3 0.713 -0.141 1 0.587
MEKK6MEKK6 0.712 0.030 1 0.606
MARK2MARK2 0.712 0.001 4 0.564
BRSK2BRSK2 0.711 -0.022 -3 0.663
HGKHGK 0.711 0.020 3 0.730
BRAFBRAF 0.711 -0.138 -4 0.720
IRAK4IRAK4 0.711 -0.086 1 0.626
GRK3GRK3 0.710 -0.041 -2 0.610
KHS2KHS2 0.710 0.077 1 0.555
MAP3K15MAP3K15 0.710 0.017 1 0.548
CK1G1CK1G1 0.710 -0.004 -3 0.465
NEK11NEK11 0.710 -0.091 1 0.561
CK2A2CK2A2 0.710 0.018 1 0.573
ROCK1ROCK1 0.709 0.140 -3 0.632
TAO2TAO2 0.709 -0.050 2 0.682
EEF2KEEF2K 0.709 -0.026 3 0.691
KHS1KHS1 0.709 0.062 1 0.547
ZAKZAK 0.709 -0.150 1 0.555
CAMKK2CAMKK2 0.709 -0.072 -2 0.618
HRIHRI 0.709 -0.187 -2 0.718
CAMK1ACAMK1A 0.709 0.100 -3 0.578
MINKMINK 0.708 -0.001 1 0.560
LRRK2LRRK2 0.708 -0.033 2 0.685
CHK2CHK2 0.707 0.085 -3 0.573
NEK1NEK1 0.707 0.001 1 0.599
NEK4NEK4 0.705 -0.075 1 0.573
CAMKK1CAMKK1 0.705 -0.156 -2 0.619
BIKEBIKE 0.705 0.135 1 0.717
PKN1PKN1 0.705 0.059 -3 0.627
MARK1MARK1 0.705 -0.023 4 0.611
VRK1VRK1 0.705 -0.064 2 0.664
CK2A1CK2A1 0.705 0.025 1 0.547
NEK8NEK8 0.704 -0.172 2 0.646
SNRKSNRK 0.704 -0.121 2 0.550
MST2MST2 0.703 -0.093 1 0.579
LOKLOK 0.702 -0.040 -2 0.669
AAK1AAK1 0.702 0.187 1 0.671
HASPINHASPIN 0.702 0.014 -1 0.539
PAK4PAK4 0.701 0.057 -2 0.634
PAK5PAK5 0.701 0.045 -2 0.624
TAK1TAK1 0.699 -0.148 1 0.599
PLK2PLK2 0.699 -0.051 -3 0.629
STK33STK33 0.698 -0.076 2 0.553
YANK3YANK3 0.697 0.007 2 0.425
MYO3BMYO3B 0.697 0.050 2 0.662
YSK1YSK1 0.696 -0.020 2 0.628
PHKG2PHKG2 0.695 -0.055 -3 0.638
TTBK1TTBK1 0.693 -0.163 2 0.545
PKG1PKG1 0.692 0.084 -2 0.610
CK1ACK1A 0.691 0.025 -3 0.353
MST1MST1 0.691 -0.135 1 0.553
OSR1OSR1 0.691 -0.072 2 0.624
SLKSLK 0.691 -0.113 -2 0.621
NEK3NEK3 0.689 -0.073 1 0.568
TTKTTK 0.689 -0.073 -2 0.730
MEK2MEK2 0.688 -0.195 2 0.635
ASK1ASK1 0.687 -0.074 1 0.535
IRAK1IRAK1 0.685 -0.287 -1 0.558
ALPHAK3ALPHAK3 0.684 -0.095 -1 0.598
MYO3AMYO3A 0.681 -0.055 1 0.560
TAO1TAO1 0.680 -0.067 1 0.501
PDHK3_TYRPDHK3_TYR 0.674 0.284 4 0.779
RIPK2RIPK2 0.674 -0.283 1 0.508
MAP2K4_TYRMAP2K4_TYR 0.666 0.208 -1 0.719
PKMYT1_TYRPKMYT1_TYR 0.665 0.234 3 0.676
LIMK2_TYRLIMK2_TYR 0.665 0.197 -3 0.713
MAP2K6_TYRMAP2K6_TYR 0.663 0.119 -1 0.709
PDHK4_TYRPDHK4_TYR 0.663 0.095 2 0.750
TESK1_TYRTESK1_TYR 0.662 0.077 3 0.717
CK1G3CK1G3 0.661 -0.048 -3 0.318
YANK2YANK2 0.660 -0.041 2 0.438
BMPR2_TYRBMPR2_TYR 0.657 0.039 -1 0.705
STLK3STLK3 0.657 -0.250 1 0.514
PDHK1_TYRPDHK1_TYR 0.656 0.001 -1 0.708
MAP2K7_TYRMAP2K7_TYR 0.656 -0.015 2 0.718
EPHA6EPHA6 0.654 0.020 -1 0.638
CK1G2CK1G2 0.651 -0.033 -3 0.388
EPHB4EPHB4 0.650 -0.010 -1 0.607
PINK1_TYRPINK1_TYR 0.649 -0.103 1 0.661
LIMK1_TYRLIMK1_TYR 0.649 -0.005 2 0.698
ABL2ABL2 0.648 0.019 -1 0.612
TXKTXK 0.646 0.010 1 0.669
ABL1ABL1 0.645 0.005 -1 0.606
TNK2TNK2 0.645 0.019 3 0.563
BLKBLK 0.645 0.037 -1 0.656
FGRFGR 0.644 -0.028 1 0.703
RETRET 0.643 -0.118 1 0.600
LCKLCK 0.643 0.007 -1 0.643
DDR1DDR1 0.641 -0.080 4 0.694
MST1RMST1R 0.641 -0.127 3 0.646
ROS1ROS1 0.641 -0.094 3 0.621
YES1YES1 0.640 -0.061 -1 0.656
TNNI3K_TYRTNNI3K_TYR 0.640 0.021 1 0.657
EPHA4EPHA4 0.639 -0.042 2 0.708
TYRO3TYRO3 0.639 -0.140 3 0.639
HCKHCK 0.639 -0.072 -1 0.644
JAK2JAK2 0.639 -0.120 1 0.597
TYK2TYK2 0.637 -0.177 1 0.597
ITKITK 0.636 -0.068 -1 0.603
TNK1TNK1 0.636 -0.022 3 0.625
FYNFYN 0.635 -0.019 -1 0.630
SRMSSRMS 0.634 -0.098 1 0.656
JAK3JAK3 0.634 -0.135 1 0.584
CSF1RCSF1R 0.634 -0.144 3 0.611
FERFER 0.634 -0.157 1 0.692
EPHB3EPHB3 0.633 -0.088 -1 0.588
INSRRINSRR 0.633 -0.137 3 0.563
BMXBMX 0.632 -0.070 -1 0.537
MERTKMERTK 0.632 -0.086 3 0.592
EPHB2EPHB2 0.632 -0.088 -1 0.585
NEK10_TYRNEK10_TYR 0.632 -0.065 1 0.485
EPHB1EPHB1 0.630 -0.134 1 0.645
WEE1_TYRWEE1_TYR 0.630 -0.083 -1 0.557
JAK1JAK1 0.630 -0.057 1 0.525
KDRKDR 0.629 -0.130 3 0.573
FGFR2FGFR2 0.629 -0.159 3 0.599
DDR2DDR2 0.629 0.002 3 0.536
METMET 0.627 -0.113 3 0.609
PTK2PTK2 0.626 -0.002 -1 0.601
PTK2BPTK2B 0.625 -0.056 -1 0.557
EPHA7EPHA7 0.625 -0.091 2 0.688
KITKIT 0.624 -0.183 3 0.596
AXLAXL 0.624 -0.152 3 0.588
EPHA3EPHA3 0.624 -0.120 2 0.679
TEKTEK 0.623 -0.189 3 0.553
EPHA1EPHA1 0.623 -0.119 3 0.599
PDGFRBPDGFRB 0.623 -0.224 3 0.623
LTKLTK 0.622 -0.144 3 0.556
FGFR1FGFR1 0.621 -0.194 3 0.575
FLT1FLT1 0.621 -0.151 -1 0.628
BTKBTK 0.621 -0.214 -1 0.577
SYKSYK 0.620 -0.036 -1 0.597
LYNLYN 0.620 -0.125 3 0.532
SRCSRC 0.620 -0.085 -1 0.624
TECTEC 0.619 -0.167 -1 0.539
FGFR3FGFR3 0.619 -0.175 3 0.566
FLT3FLT3 0.619 -0.251 3 0.627
PTK6PTK6 0.619 -0.208 -1 0.523
EPHA5EPHA5 0.618 -0.109 2 0.684
EPHA8EPHA8 0.618 -0.098 -1 0.586
MATKMATK 0.617 -0.130 -1 0.548
FRKFRK 0.617 -0.159 -1 0.653
ALKALK 0.617 -0.195 3 0.537
ERBB2ERBB2 0.617 -0.192 1 0.547
PDGFRAPDGFRA 0.615 -0.266 3 0.628
EGFREGFR 0.614 -0.111 1 0.474
NTRK1NTRK1 0.614 -0.236 -1 0.596
INSRINSR 0.612 -0.199 3 0.557
NTRK3NTRK3 0.611 -0.171 -1 0.555
CSKCSK 0.610 -0.150 2 0.688
EPHA2EPHA2 0.609 -0.112 -1 0.557
FLT4FLT4 0.607 -0.247 3 0.554
FGFR4FGFR4 0.606 -0.144 -1 0.568
ERBB4ERBB4 0.605 -0.090 1 0.507
ZAP70ZAP70 0.604 -0.047 -1 0.529
NTRK2NTRK2 0.603 -0.301 3 0.548
IGF1RIGF1R 0.601 -0.178 3 0.488
MUSKMUSK 0.599 -0.173 1 0.479
FESFES 0.586 -0.196 -1 0.506