Motif 1198 (n=55)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
B2RPK0 | HMGB1P1 | S14 | ochoa | High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) | Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}. |
O43760 | SYNGR2 | S14 | ochoa | Synaptogyrin-2 (Cellugyrin) | May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}.; FUNCTION: (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}. |
O60508 | CDC40 | S14 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
O60547 | GMDS | S14 | ochoa | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}. |
O75122 | CLASP2 | S14 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
O75907 | DGAT1 | S14 | ochoa | Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) | Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q8MK44, ECO:0000250|UniProtKB:Q9Z2A7, ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:18768481, ECO:0000269|PubMed:28420705, ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0000269|PubMed:9756920}. |
O94811 | TPPP | T14 | ochoa|psp | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
O95238 | SPDEF | S14 | ochoa | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
O95295 | SNAPIN | T14 | ochoa | SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}. |
P08195 | SLC3A2 | S14 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
P09429 | HMGB1 | S14 | ochoa | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
P16989 | YBX3 | T14 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
P26583 | HMGB2 | S14 | ochoa | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}. |
P43243 | MATR3 | S14 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
P49006 | MARCKSL1 | T14 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
P52272 | HNRNPM | T14 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
P52926 | HMGA2 | S14 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
P60468 | SEC61B | S14 | ochoa | Protein transport protein Sec61 subunit beta | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
P60709 | ACTB | S14 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
P62995 | TRA2B | S14 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
P63261 | ACTG1 | S14 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
Q01196 | RUNX1 | T14 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
Q07666 | KHDRBS1 | S14 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
Q08495 | DMTN | S14 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q08499 | PDE4D | S14 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
Q13595 | TRA2A | S14 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
Q14061 | COX17 | S14 | ochoa | Cytochrome c oxidase copper chaperone | Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). {ECO:0000269|PubMed:19393246}. |
Q14444 | CAPRIN1 | S14 | ochoa | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
Q14562 | DHX8 | S14 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
Q15878 | CACNA1E | S14 | ochoa | Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3) | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. {ECO:0000269|PubMed:30343943, ECO:0000269|PubMed:7536609}.; FUNCTION: [Isoform 3]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. {ECO:0000269|PubMed:8071363}. |
Q63ZY3 | KANK2 | T14 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q6TDP4 | KLHL17 | S14 | ochoa | Kelch-like protein 17 (Actinfilin) | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}. |
Q6ZSY5 | PPP1R3F | S14 | ochoa|psp | Protein phosphatase 1 regulatory subunit 3F (R3F) | Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}. |
Q75QN2 | INTS8 | S14 | ochoa | Integrator complex subunit 8 (Int8) (Protein kaonashi-1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:28542170, ECO:0000269|PubMed:32966759, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:38570683}. |
Q8IY67 | RAVER1 | S14 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
Q96EB6 | SIRT1 | S14 | ochoa|psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
Q96MH2 | HEXIM2 | S14 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
Q96QD5 | DEPDC7 | S14 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
Q96T60 | PNKP | S14 | ochoa | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785}. |
Q99640 | PKMYT1 | T14 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
Q9GZR2 | REXO4 | S14 | ochoa | RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) | None |
Q9H1K1 | ISCU | S14 | ochoa|psp | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}. |
Q9H6Y2 | WDR55 | S14 | ochoa | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
Q9NP87 | POLM | S14 | ochoa | DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) | Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269|PubMed:12640116, ECO:0000269|PubMed:12888504, ECO:0000269|PubMed:17483519, ECO:0000269|PubMed:17915942}. |
Q9NS37 | CREBZF | S14 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
Q9UHY1 | NRBP1 | S14 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
Q9UK33 | ZNF580 | S14 | ochoa | Zinc finger protein 580 (LDL-induced EC protein) | Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}. |
Q9UKM7 | MAN1B1 | S14 | ochoa | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1) | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}. |
Q9ULW5 | RAB26 | T14 | ochoa | Ras-related protein Rab-26 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane (PubMed:23105096). Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (PubMed:20038531). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity). {ECO:0000250|UniProtKB:P51156, ECO:0000250|UniProtKB:P61006, ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}. |
Q9UNI6 | DUSP12 | S14 | ochoa | Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}. |
Q9Y210 | TRPC6 | S14 | psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
Q9Y5L4 | TIMM13 | S14 | ochoa | Mitochondrial import inner membrane translocase subunit Tim13 | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
P62917 | RPL8 | S14 | Sugiyama | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
O15347 | HMGB3 | S14 | Sugiyama | High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}. |
Q13164 | MAPK7 | S14 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000119 | 3.923 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.000186 | 3.731 |
R-HSA-196025 | Formation of annular gap junctions | 0.000886 | 3.052 |
R-HSA-190873 | Gap junction degradation | 0.001052 | 2.978 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.001232 | 2.909 |
R-HSA-4793950 | Defective MAN1B1 causes MRT15 | 0.015529 | 1.809 |
R-HSA-198765 | Signalling to ERK5 | 0.015529 | 1.809 |
R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.019374 | 1.713 |
R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.027020 | 1.568 |
R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.027020 | 1.568 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.030821 | 1.511 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.034608 | 1.461 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.042137 | 1.375 |
R-HSA-390450 | Folding of actin by CCT/TriC | 0.049608 | 1.304 |
R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.053322 | 1.273 |
R-HSA-202670 | ERKs are inactivated | 0.057022 | 1.244 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.064379 | 1.191 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.093246 | 1.030 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.096792 | 1.014 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.100325 | 0.999 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.107349 | 0.969 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.141669 | 0.849 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.011525 | 1.938 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.058712 | 1.231 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.059745 | 1.224 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.063941 | 1.194 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.009818 | 2.008 |
R-HSA-192823 | Viral mRNA Translation | 0.073730 | 1.132 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.007116 | 2.148 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.038379 | 1.416 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.085129 | 1.070 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.033440 | 1.476 |
R-HSA-156902 | Peptide chain elongation | 0.055651 | 1.255 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.085129 | 1.070 |
R-HSA-9948299 | Ribosome-associated quality control | 0.123381 | 0.909 |
R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.042137 | 1.375 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.103843 | 0.984 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.093246 | 1.030 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.065005 | 1.187 |
R-HSA-72172 | mRNA Splicing | 0.011634 | 1.934 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.013056 | 1.884 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.015992 | 1.796 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.134910 | 0.870 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.080507 | 1.094 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.065005 | 1.187 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.015992 | 1.796 |
R-HSA-198753 | ERK/MAPK targets | 0.096792 | 1.014 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.019182 | 1.717 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.019182 | 1.717 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.019182 | 1.717 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.045879 | 1.338 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.051661 | 1.287 |
R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.023205 | 1.634 |
R-HSA-69478 | G2/M DNA replication checkpoint | 0.034608 | 1.461 |
R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.060707 | 1.217 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.007549 | 2.122 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.064379 | 1.191 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.064379 | 1.191 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.065005 | 1.187 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.029790 | 1.526 |
R-HSA-6802949 | Signaling by RAS mutants | 0.019182 | 1.717 |
R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.121236 | 0.916 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.060785 | 1.216 |
R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.027020 | 1.568 |
R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.049608 | 1.304 |
R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.093246 | 1.030 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.080507 | 1.094 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.131206 | 0.882 |
R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.148375 | 0.829 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.148375 | 0.829 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.114319 | 0.942 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.114319 | 0.942 |
R-HSA-2408557 | Selenocysteine synthesis | 0.071515 | 1.146 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.095814 | 1.019 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.095814 | 1.019 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.099457 | 1.002 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.099457 | 1.002 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.038379 | 1.416 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.060707 | 1.217 |
R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.060707 | 1.217 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.110841 | 0.955 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.128100 | 0.892 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.074846 | 1.126 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.127279 | 0.895 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.060707 | 1.217 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.125976 | 0.900 |
R-HSA-9664417 | Leishmania phagocytosis | 0.125976 | 0.900 |
R-HSA-9664407 | Parasite infection | 0.125976 | 0.900 |
R-HSA-437239 | Recycling pathway of L1 | 0.019849 | 1.702 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.068036 | 1.167 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.071679 | 1.145 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.082525 | 1.083 |
R-HSA-190828 | Gap junction trafficking | 0.017876 | 1.748 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.145029 | 0.839 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.092210 | 1.035 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.027043 | 1.568 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.137814 | 0.861 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.009395 | 2.027 |
R-HSA-1236974 | ER-Phagosome pathway | 0.056665 | 1.247 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.068036 | 1.167 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.021213 | 1.673 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.092210 | 1.035 |
R-HSA-9659379 | Sensory processing of sound | 0.045883 | 1.338 |
R-HSA-6787639 | GDP-fucose biosynthesis | 0.082525 | 1.083 |
R-HSA-3295583 | TRP channels | 0.117784 | 0.929 |
R-HSA-75109 | Triglyceride biosynthesis | 0.121236 | 0.916 |
R-HSA-1268020 | Mitochondrial protein import | 0.030978 | 1.509 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.035978 | 1.444 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.147185 | 0.832 |
R-HSA-9711097 | Cellular response to starvation | 0.151242 | 0.820 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.040365 | 1.394 |
R-HSA-9609507 | Protein localization | 0.029664 | 1.528 |
R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 0.064379 | 1.191 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.026283 | 1.580 |
R-HSA-418360 | Platelet calcium homeostasis | 0.128100 | 0.892 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.089686 | 1.047 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.019849 | 1.702 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.145029 | 0.839 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.145029 | 0.839 |
R-HSA-8953854 | Metabolism of RNA | 0.049316 | 1.307 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.002592 | 2.586 |
R-HSA-9629569 | Protein hydroxylation | 0.093246 | 1.030 |
R-HSA-210991 | Basigin interactions | 0.096792 | 1.014 |
R-HSA-9865881 | Complex III assembly | 0.110841 | 0.955 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.143152 | 0.844 |
R-HSA-373760 | L1CAM interactions | 0.092210 | 1.035 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.008880 | 2.052 |
R-HSA-180024 | DARPP-32 events | 0.128100 | 0.892 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.080507 | 1.094 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.080507 | 1.094 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.068234 | 1.166 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.068234 | 1.166 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.068234 | 1.166 |
R-HSA-156711 | Polo-like kinase mediated events | 0.086112 | 1.065 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.081655 | 1.088 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.082808 | 1.082 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.082808 | 1.082 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.077094 | 1.113 |
R-HSA-9945266 | Differentiation of T cells | 0.075308 | 1.123 |
R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.075308 | 1.123 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.042175 | 1.375 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.086297 | 1.064 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.089831 | 1.047 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.141669 | 0.849 |
R-HSA-9694301 | Maturation of replicase proteins | 0.038379 | 1.416 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.039661 | 1.402 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.039661 | 1.402 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.063444 | 1.198 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.028361 | 1.547 |
R-HSA-376176 | Signaling by ROBO receptors | 0.056528 | 1.248 |
R-HSA-418990 | Adherens junctions interactions | 0.066713 | 1.176 |
R-HSA-446728 | Cell junction organization | 0.111531 | 0.953 |
R-HSA-421270 | Cell-cell junction organization | 0.090144 | 1.045 |
R-HSA-1500931 | Cell-Cell communication | 0.144551 | 0.840 |
R-HSA-5620971 | Pyroptosis | 0.124674 | 0.904 |
R-HSA-422475 | Axon guidance | 0.006552 | 2.184 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.052327 | 1.281 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.017876 | 1.748 |
R-HSA-9675108 | Nervous system development | 0.009123 | 2.040 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.060785 | 1.216 |
R-HSA-75153 | Apoptotic execution phase | 0.019182 | 1.717 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.103843 | 0.984 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.091018 | 1.041 |
R-HSA-194138 | Signaling by VEGF | 0.104376 | 0.981 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.151709 | 0.819 |
R-HSA-8853659 | RET signaling | 0.155030 | 0.810 |
R-HSA-109581 | Apoptosis | 0.156686 | 0.805 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.158339 | 0.800 |
R-HSA-549127 | SLC-mediated transport of organic cations | 0.158339 | 0.800 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.159423 | 0.797 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.164917 | 0.783 |
R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.164917 | 0.783 |
R-HSA-5260271 | Diseases of Immune System | 0.168187 | 0.774 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.168187 | 0.774 |
R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.168187 | 0.774 |
R-HSA-71240 | Tryptophan catabolism | 0.168187 | 0.774 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.169069 | 0.772 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.171445 | 0.766 |
R-HSA-9694548 | Maturation of spike protein | 0.171445 | 0.766 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.174627 | 0.758 |
R-HSA-611105 | Respiratory electron transport | 0.180215 | 0.744 |
R-HSA-168255 | Influenza Infection | 0.181616 | 0.741 |
R-HSA-2559583 | Cellular Senescence | 0.183020 | 0.738 |
R-HSA-373752 | Netrin-1 signaling | 0.184350 | 0.734 |
R-HSA-73894 | DNA Repair | 0.186261 | 0.730 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.187545 | 0.727 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.193898 | 0.712 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.194302 | 0.712 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.197057 | 0.705 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.198556 | 0.702 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.200203 | 0.699 |
R-HSA-9864848 | Complex IV assembly | 0.206459 | 0.685 |
R-HSA-72187 | mRNA 3'-end processing | 0.209569 | 0.679 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.209569 | 0.679 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.212667 | 0.672 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.212667 | 0.672 |
R-HSA-5357801 | Programmed Cell Death | 0.219992 | 0.658 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.227979 | 0.642 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.231006 | 0.636 |
R-HSA-8979227 | Triglyceride metabolism | 0.231006 | 0.636 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.234021 | 0.631 |
R-HSA-8873719 | RAB geranylgeranylation | 0.234021 | 0.631 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.234021 | 0.631 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.235966 | 0.627 |
R-HSA-1266738 | Developmental Biology | 0.236315 | 0.627 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.237025 | 0.625 |
R-HSA-450294 | MAP kinase activation | 0.237025 | 0.625 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.240017 | 0.620 |
R-HSA-9707616 | Heme signaling | 0.240017 | 0.620 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.240017 | 0.620 |
R-HSA-8848021 | Signaling by PTK6 | 0.242997 | 0.614 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.242997 | 0.614 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.250309 | 0.602 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.254805 | 0.594 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.257728 | 0.589 |
R-HSA-5218859 | Regulated Necrosis | 0.257728 | 0.589 |
R-HSA-72766 | Translation | 0.257906 | 0.589 |
R-HSA-72312 | rRNA processing | 0.259007 | 0.587 |
R-HSA-448424 | Interleukin-17 signaling | 0.263541 | 0.579 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.263541 | 0.579 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.266431 | 0.574 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.266431 | 0.574 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.269309 | 0.570 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.269309 | 0.570 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.272177 | 0.565 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.277878 | 0.556 |
R-HSA-5689603 | UCH proteinases | 0.280713 | 0.552 |
R-HSA-9694635 | Translation of Structural Proteins | 0.283536 | 0.547 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.286349 | 0.543 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.291941 | 0.535 |
R-HSA-5654738 | Signaling by FGFR2 | 0.291941 | 0.535 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.296709 | 0.528 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.297490 | 0.527 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.297490 | 0.527 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.302997 | 0.519 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.302997 | 0.519 |
R-HSA-8953897 | Cellular responses to stimuli | 0.304680 | 0.516 |
R-HSA-416476 | G alpha (q) signalling events | 0.305386 | 0.515 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.308461 | 0.511 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.308461 | 0.511 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.311177 | 0.507 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.311177 | 0.507 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.313882 | 0.503 |
R-HSA-73884 | Base Excision Repair | 0.321937 | 0.492 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.324601 | 0.489 |
R-HSA-9658195 | Leishmania infection | 0.329866 | 0.482 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.329866 | 0.482 |
R-HSA-391251 | Protein folding | 0.329898 | 0.482 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.329898 | 0.482 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.337767 | 0.471 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.341313 | 0.467 |
R-HSA-422356 | Regulation of insulin secretion | 0.348118 | 0.458 |
R-HSA-190236 | Signaling by FGFR | 0.348118 | 0.458 |
R-HSA-3214847 | HATs acetylate histones | 0.350681 | 0.455 |
R-HSA-9614085 | FOXO-mediated transcription | 0.350681 | 0.455 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.351283 | 0.454 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.353234 | 0.452 |
R-HSA-9020702 | Interleukin-1 signaling | 0.355777 | 0.449 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.358310 | 0.446 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.358310 | 0.446 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.363347 | 0.440 |
R-HSA-111885 | Opioid Signalling | 0.363347 | 0.440 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.368345 | 0.434 |
R-HSA-418346 | Platelet homeostasis | 0.370829 | 0.431 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.370829 | 0.431 |
R-HSA-2672351 | Stimuli-sensing channels | 0.375770 | 0.425 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.378225 | 0.422 |
R-HSA-2262752 | Cellular responses to stress | 0.384198 | 0.415 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.387954 | 0.411 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.389243 | 0.410 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.390362 | 0.409 |
R-HSA-9679506 | SARS-CoV Infections | 0.392808 | 0.406 |
R-HSA-1474244 | Extracellular matrix organization | 0.400314 | 0.398 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.406963 | 0.390 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.411624 | 0.385 |
R-HSA-3371556 | Cellular response to heat stress | 0.411624 | 0.385 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.414027 | 0.383 |
R-HSA-5683057 | MAPK family signaling cascades | 0.422182 | 0.374 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.423119 | 0.374 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.423119 | 0.374 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.423119 | 0.374 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.424888 | 0.372 |
R-HSA-69481 | G2/M Checkpoints | 0.427655 | 0.369 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.429909 | 0.367 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.438841 | 0.358 |
R-HSA-9909396 | Circadian clock | 0.441053 | 0.356 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.451981 | 0.345 |
R-HSA-163685 | Integration of energy metabolism | 0.451981 | 0.345 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.458769 | 0.338 |
R-HSA-9824446 | Viral Infection Pathways | 0.469685 | 0.328 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.471170 | 0.327 |
R-HSA-166520 | Signaling by NTRKs | 0.479422 | 0.319 |
R-HSA-446652 | Interleukin-1 family signaling | 0.487589 | 0.312 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.489074 | 0.311 |
R-HSA-199991 | Membrane Trafficking | 0.489188 | 0.311 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.489612 | 0.310 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.491626 | 0.308 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.497622 | 0.303 |
R-HSA-5663205 | Infectious disease | 0.510452 | 0.292 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.511344 | 0.291 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.512374 | 0.290 |
R-HSA-5619102 | SLC transporter disorders | 0.517111 | 0.286 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.520113 | 0.284 |
R-HSA-74160 | Gene expression (Transcription) | 0.524164 | 0.281 |
R-HSA-418555 | G alpha (s) signalling events | 0.526574 | 0.279 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.534013 | 0.272 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.534013 | 0.272 |
R-HSA-3781865 | Diseases of glycosylation | 0.550333 | 0.259 |
R-HSA-69275 | G2/M Transition | 0.553883 | 0.257 |
R-HSA-382551 | Transport of small molecules | 0.556676 | 0.254 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.557405 | 0.254 |
R-HSA-983712 | Ion channel transport | 0.559155 | 0.252 |
R-HSA-6798695 | Neutrophil degranulation | 0.561469 | 0.251 |
R-HSA-68877 | Mitotic Prometaphase | 0.566090 | 0.247 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.582961 | 0.234 |
R-HSA-68882 | Mitotic Anaphase | 0.605501 | 0.218 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.607064 | 0.217 |
R-HSA-388396 | GPCR downstream signalling | 0.607130 | 0.217 |
R-HSA-109582 | Hemostasis | 0.615713 | 0.211 |
R-HSA-168249 | Innate Immune System | 0.616753 | 0.210 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.624394 | 0.205 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.632727 | 0.199 |
R-HSA-5653656 | Vesicle-mediated transport | 0.635813 | 0.197 |
R-HSA-8939211 | ESR-mediated signaling | 0.637081 | 0.196 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.637081 | 0.196 |
R-HSA-157118 | Signaling by NOTCH | 0.641384 | 0.193 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.651231 | 0.186 |
R-HSA-4839726 | Chromatin organization | 0.653995 | 0.184 |
R-HSA-5688426 | Deubiquitination | 0.662159 | 0.179 |
R-HSA-162582 | Signal Transduction | 0.667106 | 0.176 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.673899 | 0.171 |
R-HSA-372790 | Signaling by GPCR | 0.674612 | 0.171 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.686780 | 0.163 |
R-HSA-1483257 | Phospholipid metabolism | 0.711942 | 0.148 |
R-HSA-449147 | Signaling by Interleukins | 0.724562 | 0.140 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.742419 | 0.129 |
R-HSA-212436 | Generic Transcription Pathway | 0.749064 | 0.125 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.780526 | 0.108 |
R-HSA-1640170 | Cell Cycle | 0.784659 | 0.105 |
R-HSA-68886 | M Phase | 0.797442 | 0.098 |
R-HSA-597592 | Post-translational protein modification | 0.799616 | 0.097 |
R-HSA-1643685 | Disease | 0.808348 | 0.092 |
R-HSA-418594 | G alpha (i) signalling events | 0.816791 | 0.088 |
R-HSA-5668914 | Diseases of metabolism | 0.830950 | 0.080 |
R-HSA-112316 | Neuronal System | 0.856694 | 0.067 |
R-HSA-392499 | Metabolism of proteins | 0.856926 | 0.067 |
R-HSA-1280218 | Adaptive Immune System | 0.927180 | 0.033 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.933759 | 0.030 |
R-HSA-9709957 | Sensory Perception | 0.962292 | 0.017 |
R-HSA-168256 | Immune System | 0.972485 | 0.012 |
R-HSA-1430728 | Metabolism | 0.995855 | 0.002 |
R-HSA-556833 | Metabolism of lipids | 0.997968 | 0.001 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.790 | 0.344 | 1 | 0.758 |
DYRK2 |
0.782 | 0.345 | 1 | 0.776 |
CLK2 |
0.782 | 0.350 | -3 | 0.669 |
HIPK4 |
0.782 | 0.343 | 1 | 0.775 |
HIPK2 |
0.781 | 0.345 | 1 | 0.731 |
SRPK1 |
0.780 | 0.277 | -3 | 0.702 |
HIPK1 |
0.779 | 0.352 | 1 | 0.782 |
MAK |
0.775 | 0.361 | -2 | 0.725 |
DYRK4 |
0.774 | 0.322 | 1 | 0.732 |
CDKL5 |
0.771 | 0.246 | -3 | 0.723 |
ICK |
0.769 | 0.274 | -3 | 0.745 |
MOS |
0.768 | 0.187 | 1 | 0.713 |
CDKL1 |
0.767 | 0.221 | -3 | 0.723 |
CLK4 |
0.767 | 0.278 | -3 | 0.678 |
KIS |
0.767 | 0.277 | 1 | 0.746 |
PIM3 |
0.766 | 0.199 | -3 | 0.730 |
DYRK3 |
0.766 | 0.319 | 1 | 0.780 |
CDK18 |
0.764 | 0.296 | 1 | 0.705 |
COT |
0.764 | 0.121 | 2 | 0.705 |
NLK |
0.764 | 0.218 | 1 | 0.762 |
JNK2 |
0.763 | 0.276 | 1 | 0.691 |
ERK5 |
0.763 | 0.207 | 1 | 0.812 |
PRKD1 |
0.763 | 0.245 | -3 | 0.730 |
DYRK1A |
0.762 | 0.285 | 1 | 0.747 |
RSK2 |
0.762 | 0.207 | -3 | 0.692 |
PIM1 |
0.762 | 0.209 | -3 | 0.680 |
SKMLCK |
0.762 | 0.219 | -2 | 0.826 |
CDK5 |
0.762 | 0.267 | 1 | 0.754 |
CLK1 |
0.761 | 0.269 | -3 | 0.647 |
P38B |
0.761 | 0.271 | 1 | 0.735 |
HIPK3 |
0.760 | 0.304 | 1 | 0.755 |
CDK3 |
0.760 | 0.258 | 1 | 0.681 |
CDK1 |
0.760 | 0.243 | 1 | 0.708 |
DYRK1B |
0.760 | 0.291 | 1 | 0.731 |
P38A |
0.760 | 0.270 | 1 | 0.774 |
SRPK2 |
0.759 | 0.213 | -3 | 0.638 |
MTOR |
0.759 | 0.219 | 1 | 0.635 |
JNK3 |
0.759 | 0.252 | 1 | 0.717 |
CDK7 |
0.758 | 0.245 | 1 | 0.740 |
SRPK3 |
0.758 | 0.189 | -3 | 0.673 |
AURC |
0.758 | 0.201 | -2 | 0.682 |
CAMK1B |
0.758 | 0.144 | -3 | 0.718 |
CDK8 |
0.757 | 0.230 | 1 | 0.731 |
CDC7 |
0.757 | 0.089 | 1 | 0.666 |
MOK |
0.757 | 0.328 | 1 | 0.819 |
P38G |
0.757 | 0.254 | 1 | 0.657 |
CDK19 |
0.757 | 0.245 | 1 | 0.713 |
CDK13 |
0.757 | 0.240 | 1 | 0.719 |
PRKD2 |
0.757 | 0.207 | -3 | 0.672 |
NDR2 |
0.757 | 0.177 | -3 | 0.714 |
P90RSK |
0.757 | 0.184 | -3 | 0.714 |
CDK12 |
0.756 | 0.255 | 1 | 0.696 |
CAMLCK |
0.755 | 0.166 | -2 | 0.786 |
PRPK |
0.755 | 0.026 | -1 | 0.688 |
PKACB |
0.754 | 0.221 | -2 | 0.690 |
P38D |
0.754 | 0.249 | 1 | 0.692 |
DAPK2 |
0.753 | 0.165 | -3 | 0.729 |
GSK3A |
0.753 | 0.230 | 4 | 0.567 |
CDK14 |
0.753 | 0.268 | 1 | 0.718 |
PRP4 |
0.753 | 0.278 | -3 | 0.781 |
RSK3 |
0.752 | 0.176 | -3 | 0.690 |
CDK10 |
0.752 | 0.263 | 1 | 0.716 |
ERK1 |
0.751 | 0.228 | 1 | 0.727 |
CDK17 |
0.751 | 0.245 | 1 | 0.657 |
ATR |
0.751 | 0.026 | 1 | 0.651 |
GRK1 |
0.751 | 0.096 | -2 | 0.735 |
RSK4 |
0.750 | 0.187 | -3 | 0.676 |
AKT2 |
0.750 | 0.196 | -3 | 0.624 |
PKACG |
0.749 | 0.164 | -2 | 0.729 |
MPSK1 |
0.748 | 0.274 | 1 | 0.731 |
NDR1 |
0.748 | 0.127 | -3 | 0.700 |
NUAK2 |
0.748 | 0.115 | -3 | 0.706 |
PKN3 |
0.747 | 0.077 | -3 | 0.710 |
CDK9 |
0.747 | 0.225 | 1 | 0.721 |
NIK |
0.747 | 0.069 | -3 | 0.710 |
LATS1 |
0.747 | 0.144 | -3 | 0.732 |
PRKX |
0.747 | 0.220 | -3 | 0.600 |
MAPKAPK2 |
0.747 | 0.141 | -3 | 0.643 |
CAMK2G |
0.746 | -0.001 | 2 | 0.748 |
CAMK2D |
0.746 | 0.109 | -3 | 0.696 |
MST4 |
0.746 | 0.117 | 2 | 0.704 |
BMPR2 |
0.746 | -0.098 | -2 | 0.754 |
BMPR1B |
0.746 | 0.081 | 1 | 0.644 |
WNK1 |
0.746 | 0.056 | -2 | 0.793 |
PKCD |
0.745 | 0.119 | 2 | 0.635 |
CHAK2 |
0.745 | 0.038 | -1 | 0.623 |
CAMK2A |
0.745 | 0.135 | 2 | 0.736 |
P70S6KB |
0.745 | 0.123 | -3 | 0.677 |
CDK16 |
0.744 | 0.242 | 1 | 0.675 |
GRK7 |
0.744 | 0.094 | 1 | 0.587 |
PAK1 |
0.744 | 0.132 | -2 | 0.748 |
PIM2 |
0.743 | 0.173 | -3 | 0.655 |
AMPKA1 |
0.743 | 0.102 | -3 | 0.703 |
MAPKAPK3 |
0.743 | 0.109 | -3 | 0.663 |
MSK1 |
0.743 | 0.169 | -3 | 0.668 |
CAMK2B |
0.742 | 0.113 | 2 | 0.730 |
MNK2 |
0.742 | 0.138 | -2 | 0.754 |
TSSK2 |
0.742 | 0.085 | -5 | 0.760 |
PRKD3 |
0.741 | 0.140 | -3 | 0.654 |
AURB |
0.741 | 0.143 | -2 | 0.670 |
SGK3 |
0.741 | 0.176 | -3 | 0.657 |
JNK1 |
0.741 | 0.208 | 1 | 0.684 |
PDHK4 |
0.740 | -0.136 | 1 | 0.648 |
GSK3B |
0.740 | 0.157 | 4 | 0.561 |
MARK4 |
0.740 | 0.087 | 4 | 0.677 |
AMPKA2 |
0.740 | 0.114 | -3 | 0.680 |
PKG2 |
0.739 | 0.148 | -2 | 0.684 |
PKN2 |
0.739 | 0.066 | -3 | 0.681 |
NEK6 |
0.739 | -0.015 | -2 | 0.753 |
MNK1 |
0.739 | 0.121 | -2 | 0.763 |
TSSK1 |
0.739 | 0.102 | -3 | 0.722 |
MSK2 |
0.739 | 0.133 | -3 | 0.683 |
RAF1 |
0.738 | -0.104 | 1 | 0.608 |
PKCB |
0.738 | 0.106 | 2 | 0.560 |
DCAMKL1 |
0.738 | 0.138 | -3 | 0.669 |
GRK5 |
0.738 | -0.086 | -3 | 0.686 |
TGFBR1 |
0.738 | 0.036 | -2 | 0.692 |
FAM20C |
0.737 | 0.105 | 2 | 0.608 |
LATS2 |
0.737 | 0.058 | -5 | 0.624 |
RIPK3 |
0.737 | -0.057 | 3 | 0.562 |
PKCA |
0.737 | 0.113 | 2 | 0.573 |
AURA |
0.737 | 0.129 | -2 | 0.649 |
VRK2 |
0.736 | 0.039 | 1 | 0.713 |
DSTYK |
0.736 | -0.092 | 2 | 0.721 |
MASTL |
0.736 | -0.050 | -2 | 0.694 |
CDK2 |
0.736 | 0.149 | 1 | 0.730 |
IKKB |
0.736 | -0.090 | -2 | 0.608 |
PKACA |
0.736 | 0.184 | -2 | 0.647 |
PKCG |
0.735 | 0.090 | 2 | 0.592 |
TGFBR2 |
0.735 | -0.045 | -2 | 0.706 |
PAK3 |
0.735 | 0.083 | -2 | 0.731 |
GCN2 |
0.735 | -0.109 | 2 | 0.650 |
PKR |
0.735 | 0.021 | 1 | 0.661 |
ERK2 |
0.735 | 0.162 | 1 | 0.725 |
ALK4 |
0.735 | -0.014 | -2 | 0.716 |
MLK2 |
0.734 | -0.036 | 2 | 0.640 |
MYLK4 |
0.734 | 0.107 | -2 | 0.747 |
SGK1 |
0.734 | 0.202 | -3 | 0.573 |
PASK |
0.734 | 0.102 | -3 | 0.746 |
ULK2 |
0.734 | -0.116 | 2 | 0.623 |
NIM1 |
0.733 | 0.116 | 3 | 0.594 |
PKCZ |
0.733 | 0.064 | 2 | 0.606 |
MLK1 |
0.733 | -0.122 | 2 | 0.635 |
GRK6 |
0.732 | -0.066 | 1 | 0.626 |
AKT1 |
0.732 | 0.164 | -3 | 0.626 |
TBK1 |
0.731 | -0.132 | 1 | 0.499 |
MLK3 |
0.731 | -0.037 | 2 | 0.592 |
DNAPK |
0.731 | 0.056 | 1 | 0.503 |
ALK2 |
0.731 | 0.002 | -2 | 0.707 |
IRE1 |
0.731 | -0.029 | 1 | 0.637 |
ERK7 |
0.731 | 0.086 | 2 | 0.431 |
AKT3 |
0.730 | 0.189 | -3 | 0.596 |
ATM |
0.730 | -0.028 | 1 | 0.587 |
PAK2 |
0.730 | 0.063 | -2 | 0.727 |
CDK6 |
0.729 | 0.197 | 1 | 0.714 |
CK1E |
0.729 | 0.032 | -3 | 0.467 |
BUB1 |
0.729 | 0.173 | -5 | 0.680 |
RIPK1 |
0.729 | -0.098 | 1 | 0.616 |
MST3 |
0.728 | 0.088 | 2 | 0.667 |
PDHK1 |
0.728 | -0.219 | 1 | 0.623 |
QSK |
0.728 | 0.095 | 4 | 0.645 |
NEK7 |
0.728 | -0.164 | -3 | 0.695 |
TLK2 |
0.728 | -0.030 | 1 | 0.592 |
NEK9 |
0.728 | -0.115 | 2 | 0.649 |
DAPK3 |
0.728 | 0.141 | -3 | 0.683 |
IKKE |
0.728 | -0.145 | 1 | 0.491 |
CDK4 |
0.727 | 0.202 | 1 | 0.691 |
SBK |
0.727 | 0.189 | -3 | 0.534 |
DAPK1 |
0.727 | 0.146 | -3 | 0.679 |
DLK |
0.727 | -0.189 | 1 | 0.613 |
SMG1 |
0.726 | -0.035 | 1 | 0.612 |
GAK |
0.726 | 0.134 | 1 | 0.753 |
HUNK |
0.726 | -0.118 | 2 | 0.636 |
PKCE |
0.726 | 0.123 | 2 | 0.576 |
ACVR2B |
0.725 | -0.027 | -2 | 0.684 |
ROCK2 |
0.725 | 0.174 | -3 | 0.668 |
PKCH |
0.725 | 0.040 | 2 | 0.552 |
ANKRD3 |
0.725 | -0.186 | 1 | 0.651 |
MEK1 |
0.725 | -0.116 | 2 | 0.683 |
SMMLCK |
0.724 | 0.086 | -3 | 0.688 |
IKKA |
0.724 | -0.071 | -2 | 0.604 |
CAMK4 |
0.724 | -0.016 | -3 | 0.657 |
CK1D |
0.724 | 0.032 | -3 | 0.419 |
LKB1 |
0.723 | 0.092 | -3 | 0.690 |
MELK |
0.723 | 0.023 | -3 | 0.665 |
PBK |
0.723 | 0.183 | 1 | 0.725 |
CAMK1G |
0.723 | 0.067 | -3 | 0.647 |
GRK4 |
0.723 | -0.119 | -2 | 0.742 |
ACVR2A |
0.723 | -0.051 | -2 | 0.667 |
PLK1 |
0.723 | -0.092 | -2 | 0.698 |
NEK2 |
0.722 | -0.060 | 2 | 0.635 |
IRE2 |
0.722 | -0.059 | 2 | 0.598 |
TTBK2 |
0.721 | -0.136 | 2 | 0.592 |
BMPR1A |
0.721 | 0.006 | 1 | 0.614 |
DCAMKL2 |
0.721 | 0.042 | -3 | 0.670 |
CHK1 |
0.721 | 0.008 | -3 | 0.663 |
NEK5 |
0.721 | -0.035 | 1 | 0.642 |
DMPK1 |
0.720 | 0.177 | -3 | 0.637 |
SSTK |
0.720 | 0.044 | 4 | 0.640 |
CAMK1D |
0.720 | 0.102 | -3 | 0.589 |
TAO3 |
0.720 | 0.031 | 1 | 0.579 |
PHKG1 |
0.720 | -0.010 | -3 | 0.687 |
WNK4 |
0.720 | -0.020 | -2 | 0.778 |
CK1A2 |
0.720 | 0.018 | -3 | 0.420 |
QIK |
0.720 | 0.013 | -3 | 0.681 |
YSK4 |
0.720 | -0.130 | 1 | 0.542 |
MRCKB |
0.719 | 0.142 | -3 | 0.623 |
MARK3 |
0.719 | 0.042 | 4 | 0.598 |
WNK3 |
0.718 | -0.229 | 1 | 0.600 |
PKCI |
0.718 | 0.059 | 2 | 0.584 |
MEKK2 |
0.718 | -0.061 | 2 | 0.625 |
BRSK1 |
0.718 | 0.029 | -3 | 0.669 |
SIK |
0.718 | 0.076 | -3 | 0.644 |
PINK1 |
0.718 | -0.062 | 1 | 0.755 |
GRK2 |
0.718 | -0.060 | -2 | 0.631 |
PDK1 |
0.718 | 0.030 | 1 | 0.594 |
NUAK1 |
0.717 | 0.017 | -3 | 0.653 |
PKCT |
0.717 | 0.068 | 2 | 0.559 |
DRAK1 |
0.717 | -0.047 | 1 | 0.561 |
PERK |
0.717 | -0.116 | -2 | 0.710 |
MEK5 |
0.717 | -0.149 | 2 | 0.649 |
TNIK |
0.717 | 0.082 | 3 | 0.749 |
PAK6 |
0.716 | 0.053 | -2 | 0.661 |
MLK4 |
0.716 | -0.128 | 2 | 0.560 |
ULK1 |
0.716 | -0.205 | -3 | 0.662 |
MRCKA |
0.716 | 0.126 | -3 | 0.630 |
TLK1 |
0.716 | -0.101 | -2 | 0.735 |
CHAK1 |
0.716 | -0.127 | 2 | 0.628 |
PLK3 |
0.716 | -0.093 | 2 | 0.684 |
P70S6K |
0.715 | 0.079 | -3 | 0.619 |
PLK4 |
0.715 | -0.041 | 2 | 0.511 |
BCKDK |
0.715 | -0.165 | -1 | 0.597 |
GCK |
0.714 | 0.035 | 1 | 0.569 |
CRIK |
0.714 | 0.163 | -3 | 0.638 |
MAPKAPK5 |
0.714 | 0.007 | -3 | 0.641 |
MEKK1 |
0.713 | -0.128 | 1 | 0.601 |
HPK1 |
0.713 | 0.050 | 1 | 0.546 |
MEKK3 |
0.713 | -0.141 | 1 | 0.587 |
MEKK6 |
0.712 | 0.030 | 1 | 0.606 |
MARK2 |
0.712 | 0.001 | 4 | 0.564 |
BRSK2 |
0.711 | -0.022 | -3 | 0.663 |
HGK |
0.711 | 0.020 | 3 | 0.730 |
BRAF |
0.711 | -0.138 | -4 | 0.720 |
IRAK4 |
0.711 | -0.086 | 1 | 0.626 |
GRK3 |
0.710 | -0.041 | -2 | 0.610 |
KHS2 |
0.710 | 0.077 | 1 | 0.555 |
MAP3K15 |
0.710 | 0.017 | 1 | 0.548 |
CK1G1 |
0.710 | -0.004 | -3 | 0.465 |
NEK11 |
0.710 | -0.091 | 1 | 0.561 |
CK2A2 |
0.710 | 0.018 | 1 | 0.573 |
ROCK1 |
0.709 | 0.140 | -3 | 0.632 |
TAO2 |
0.709 | -0.050 | 2 | 0.682 |
EEF2K |
0.709 | -0.026 | 3 | 0.691 |
KHS1 |
0.709 | 0.062 | 1 | 0.547 |
ZAK |
0.709 | -0.150 | 1 | 0.555 |
CAMKK2 |
0.709 | -0.072 | -2 | 0.618 |
HRI |
0.709 | -0.187 | -2 | 0.718 |
CAMK1A |
0.709 | 0.100 | -3 | 0.578 |
MINK |
0.708 | -0.001 | 1 | 0.560 |
LRRK2 |
0.708 | -0.033 | 2 | 0.685 |
CHK2 |
0.707 | 0.085 | -3 | 0.573 |
NEK1 |
0.707 | 0.001 | 1 | 0.599 |
NEK4 |
0.705 | -0.075 | 1 | 0.573 |
CAMKK1 |
0.705 | -0.156 | -2 | 0.619 |
BIKE |
0.705 | 0.135 | 1 | 0.717 |
PKN1 |
0.705 | 0.059 | -3 | 0.627 |
MARK1 |
0.705 | -0.023 | 4 | 0.611 |
VRK1 |
0.705 | -0.064 | 2 | 0.664 |
CK2A1 |
0.705 | 0.025 | 1 | 0.547 |
NEK8 |
0.704 | -0.172 | 2 | 0.646 |
SNRK |
0.704 | -0.121 | 2 | 0.550 |
MST2 |
0.703 | -0.093 | 1 | 0.579 |
LOK |
0.702 | -0.040 | -2 | 0.669 |
AAK1 |
0.702 | 0.187 | 1 | 0.671 |
HASPIN |
0.702 | 0.014 | -1 | 0.539 |
PAK4 |
0.701 | 0.057 | -2 | 0.634 |
PAK5 |
0.701 | 0.045 | -2 | 0.624 |
TAK1 |
0.699 | -0.148 | 1 | 0.599 |
PLK2 |
0.699 | -0.051 | -3 | 0.629 |
STK33 |
0.698 | -0.076 | 2 | 0.553 |
YANK3 |
0.697 | 0.007 | 2 | 0.425 |
MYO3B |
0.697 | 0.050 | 2 | 0.662 |
YSK1 |
0.696 | -0.020 | 2 | 0.628 |
PHKG2 |
0.695 | -0.055 | -3 | 0.638 |
TTBK1 |
0.693 | -0.163 | 2 | 0.545 |
PKG1 |
0.692 | 0.084 | -2 | 0.610 |
CK1A |
0.691 | 0.025 | -3 | 0.353 |
MST1 |
0.691 | -0.135 | 1 | 0.553 |
OSR1 |
0.691 | -0.072 | 2 | 0.624 |
SLK |
0.691 | -0.113 | -2 | 0.621 |
NEK3 |
0.689 | -0.073 | 1 | 0.568 |
TTK |
0.689 | -0.073 | -2 | 0.730 |
MEK2 |
0.688 | -0.195 | 2 | 0.635 |
ASK1 |
0.687 | -0.074 | 1 | 0.535 |
IRAK1 |
0.685 | -0.287 | -1 | 0.558 |
ALPHAK3 |
0.684 | -0.095 | -1 | 0.598 |
MYO3A |
0.681 | -0.055 | 1 | 0.560 |
TAO1 |
0.680 | -0.067 | 1 | 0.501 |
PDHK3_TYR |
0.674 | 0.284 | 4 | 0.779 |
RIPK2 |
0.674 | -0.283 | 1 | 0.508 |
MAP2K4_TYR |
0.666 | 0.208 | -1 | 0.719 |
PKMYT1_TYR |
0.665 | 0.234 | 3 | 0.676 |
LIMK2_TYR |
0.665 | 0.197 | -3 | 0.713 |
MAP2K6_TYR |
0.663 | 0.119 | -1 | 0.709 |
PDHK4_TYR |
0.663 | 0.095 | 2 | 0.750 |
TESK1_TYR |
0.662 | 0.077 | 3 | 0.717 |
CK1G3 |
0.661 | -0.048 | -3 | 0.318 |
YANK2 |
0.660 | -0.041 | 2 | 0.438 |
BMPR2_TYR |
0.657 | 0.039 | -1 | 0.705 |
STLK3 |
0.657 | -0.250 | 1 | 0.514 |
PDHK1_TYR |
0.656 | 0.001 | -1 | 0.708 |
MAP2K7_TYR |
0.656 | -0.015 | 2 | 0.718 |
EPHA6 |
0.654 | 0.020 | -1 | 0.638 |
CK1G2 |
0.651 | -0.033 | -3 | 0.388 |
EPHB4 |
0.650 | -0.010 | -1 | 0.607 |
PINK1_TYR |
0.649 | -0.103 | 1 | 0.661 |
LIMK1_TYR |
0.649 | -0.005 | 2 | 0.698 |
ABL2 |
0.648 | 0.019 | -1 | 0.612 |
TXK |
0.646 | 0.010 | 1 | 0.669 |
ABL1 |
0.645 | 0.005 | -1 | 0.606 |
TNK2 |
0.645 | 0.019 | 3 | 0.563 |
BLK |
0.645 | 0.037 | -1 | 0.656 |
FGR |
0.644 | -0.028 | 1 | 0.703 |
RET |
0.643 | -0.118 | 1 | 0.600 |
LCK |
0.643 | 0.007 | -1 | 0.643 |
DDR1 |
0.641 | -0.080 | 4 | 0.694 |
MST1R |
0.641 | -0.127 | 3 | 0.646 |
ROS1 |
0.641 | -0.094 | 3 | 0.621 |
YES1 |
0.640 | -0.061 | -1 | 0.656 |
TNNI3K_TYR |
0.640 | 0.021 | 1 | 0.657 |
EPHA4 |
0.639 | -0.042 | 2 | 0.708 |
TYRO3 |
0.639 | -0.140 | 3 | 0.639 |
HCK |
0.639 | -0.072 | -1 | 0.644 |
JAK2 |
0.639 | -0.120 | 1 | 0.597 |
TYK2 |
0.637 | -0.177 | 1 | 0.597 |
ITK |
0.636 | -0.068 | -1 | 0.603 |
TNK1 |
0.636 | -0.022 | 3 | 0.625 |
FYN |
0.635 | -0.019 | -1 | 0.630 |
SRMS |
0.634 | -0.098 | 1 | 0.656 |
JAK3 |
0.634 | -0.135 | 1 | 0.584 |
CSF1R |
0.634 | -0.144 | 3 | 0.611 |
FER |
0.634 | -0.157 | 1 | 0.692 |
EPHB3 |
0.633 | -0.088 | -1 | 0.588 |
INSRR |
0.633 | -0.137 | 3 | 0.563 |
BMX |
0.632 | -0.070 | -1 | 0.537 |
MERTK |
0.632 | -0.086 | 3 | 0.592 |
EPHB2 |
0.632 | -0.088 | -1 | 0.585 |
NEK10_TYR |
0.632 | -0.065 | 1 | 0.485 |
EPHB1 |
0.630 | -0.134 | 1 | 0.645 |
WEE1_TYR |
0.630 | -0.083 | -1 | 0.557 |
JAK1 |
0.630 | -0.057 | 1 | 0.525 |
KDR |
0.629 | -0.130 | 3 | 0.573 |
FGFR2 |
0.629 | -0.159 | 3 | 0.599 |
DDR2 |
0.629 | 0.002 | 3 | 0.536 |
MET |
0.627 | -0.113 | 3 | 0.609 |
PTK2 |
0.626 | -0.002 | -1 | 0.601 |
PTK2B |
0.625 | -0.056 | -1 | 0.557 |
EPHA7 |
0.625 | -0.091 | 2 | 0.688 |
KIT |
0.624 | -0.183 | 3 | 0.596 |
AXL |
0.624 | -0.152 | 3 | 0.588 |
EPHA3 |
0.624 | -0.120 | 2 | 0.679 |
TEK |
0.623 | -0.189 | 3 | 0.553 |
EPHA1 |
0.623 | -0.119 | 3 | 0.599 |
PDGFRB |
0.623 | -0.224 | 3 | 0.623 |
LTK |
0.622 | -0.144 | 3 | 0.556 |
FGFR1 |
0.621 | -0.194 | 3 | 0.575 |
FLT1 |
0.621 | -0.151 | -1 | 0.628 |
BTK |
0.621 | -0.214 | -1 | 0.577 |
SYK |
0.620 | -0.036 | -1 | 0.597 |
LYN |
0.620 | -0.125 | 3 | 0.532 |
SRC |
0.620 | -0.085 | -1 | 0.624 |
TEC |
0.619 | -0.167 | -1 | 0.539 |
FGFR3 |
0.619 | -0.175 | 3 | 0.566 |
FLT3 |
0.619 | -0.251 | 3 | 0.627 |
PTK6 |
0.619 | -0.208 | -1 | 0.523 |
EPHA5 |
0.618 | -0.109 | 2 | 0.684 |
EPHA8 |
0.618 | -0.098 | -1 | 0.586 |
MATK |
0.617 | -0.130 | -1 | 0.548 |
FRK |
0.617 | -0.159 | -1 | 0.653 |
ALK |
0.617 | -0.195 | 3 | 0.537 |
ERBB2 |
0.617 | -0.192 | 1 | 0.547 |
PDGFRA |
0.615 | -0.266 | 3 | 0.628 |
EGFR |
0.614 | -0.111 | 1 | 0.474 |
NTRK1 |
0.614 | -0.236 | -1 | 0.596 |
INSR |
0.612 | -0.199 | 3 | 0.557 |
NTRK3 |
0.611 | -0.171 | -1 | 0.555 |
CSK |
0.610 | -0.150 | 2 | 0.688 |
EPHA2 |
0.609 | -0.112 | -1 | 0.557 |
FLT4 |
0.607 | -0.247 | 3 | 0.554 |
FGFR4 |
0.606 | -0.144 | -1 | 0.568 |
ERBB4 |
0.605 | -0.090 | 1 | 0.507 |
ZAP70 |
0.604 | -0.047 | -1 | 0.529 |
NTRK2 |
0.603 | -0.301 | 3 | 0.548 |
IGF1R |
0.601 | -0.178 | 3 | 0.488 |
MUSK |
0.599 | -0.173 | 1 | 0.479 |
FES |
0.586 | -0.196 | -1 | 0.506 |