Motif 1196 (n=285)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP55 | UQCRHL | S13 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
| A0A1B0GTI1 | CCDC201 | S13 | ochoa | Coiled-coil domain-containing protein 201 | None |
| A0A1W2PRX2 | None | Y13 | ochoa | Adenylosuccinate lyase | None |
| A1IGU5 | ARHGEF37 | S13 | ochoa | Rho guanine nucleotide exchange factor 37 | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| A6NHR9 | SMCHD1 | S13 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| B5ME19 | EIF3CL | S13 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| C9JI98 | TMEM238 | S13 | ochoa | Transmembrane protein 238 | None |
| O00148 | DDX39A | Y13 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O00233 | PSMD9 | S13 | ochoa | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. {ECO:0000269|PubMed:19490896}. |
| O00750 | PIK3C2B | S13 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14579 | COPE | S13 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O14713 | ITGB1BP1 | S13 | ochoa | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O15085 | ARHGEF11 | S13 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15211 | RGL2 | S13 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O43143 | DHX15 | Y13 | ochoa | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}. |
| O43707 | ACTN4 | Y13 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60437 | PPL | Y13 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60573 | EIF4E2 | S13 | ochoa | Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3) | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (PubMed:28487484, PubMed:33581076). {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:33581076, ECO:0000269|PubMed:9582349}.; FUNCTION: Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:35878012). In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) with GIGYF2 enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| O60825 | PFKFB2 | S13 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O75607 | NPM3 | S13 | ochoa | Nucleoplasmin-3 | Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:20073534, PubMed:22362753). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447). {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:20073534, ECO:0000269|PubMed:22362753}. |
| O75683 | SURF6 | S13 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O75694 | NUP155 | S13 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O75822 | EIF3J | S13 | ochoa | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O75925 | PIAS1 | S13 | psp | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O94763 | URI1 | S13 | ochoa | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| O94782 | USP1 | S13 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94804 | STK10 | S13 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94855 | SEC24D | S13 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94864 | SUPT7L | S13 | ochoa | STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) | None |
| O95926 | SYF2 | S13 | ochoa | Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| P04183 | TK1 | S13 | ochoa|psp | Thymidine kinase, cytosolic (EC 2.7.1.21) | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}. |
| P05783 | KRT18 | Y13 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07919 | UQCRH | S13 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P07948 | LYN | S13 | ochoa|psp | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08133 | ANXA6 | S13 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P14136 | GFAP | S13 | ochoa|psp | Glial fibrillary acidic protein (GFAP) | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| P15559 | NQO1 | S13 | ochoa | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}. |
| P15927 | RPA2 | S13 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P16885 | PLCG2 | Y13 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P17029 | ZKSCAN1 | S13 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P17152 | TMEM11 | S13 | ochoa | Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI) | Plays a role in mitochondrial morphogenesis. {ECO:0000269|PubMed:21274005}. |
| P17252 | PRKCA | S13 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P17661 | DES | S13 | psp | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18031 | PTPN1 | S13 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18850 | ATF6 | S13 | ochoa | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] | [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
| P20042 | EIF2S2 | S13 | ochoa | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P20700 | LMNB1 | S13 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P20962 | PTMS | S13 | ochoa | Parathymosin | Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections. |
| P21796 | VDAC1 | S13 | psp | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P22314 | UBA1 | S13 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23634 | ATP2B4 | S13 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25098 | GRK2 | Y13 | psp | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}. |
| P25788 | PSMA3 | S13 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P25789 | PSMA4 | S13 | ochoa | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P27707 | DCK | S13 | ochoa | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P27815 | PDE4A | S13 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P29762 | CRABP1 | S13 | ochoa | Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I) | Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. |
| P30086 | PEBP1 | S13 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P30566 | ADSL | Y13 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P31645 | SLC6A4 | S13 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P35240 | NF2 | S13 | ochoa|psp | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35580 | MYH10 | Y13 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35900 | KRT20 | S13 | psp | Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT) | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:0000269|PubMed:16608857}. |
| P39023 | RPL3 | S13 | ochoa | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P42858 | HTT | S13 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43007 | SLC1A4 | S13 | ochoa | Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) | Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269|PubMed:14502423, ECO:0000269|PubMed:26041762, ECO:0000269|PubMed:8101838, ECO:0000269|PubMed:8340364}. |
| P45973 | CBX5 | S13 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P49736 | MCM2 | S13 | ochoa|psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49841 | GSK3B | S13 | ochoa | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P49910 | ZNF165 | S13 | ochoa | Zinc finger protein 165 (Cancer/testis antigen 53) (CT53) (LD65) (Zinc finger and SCAN domain-containing protein 7) | May be involved in transcriptional regulation. |
| P51580 | TPMT | Y13 | ochoa | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}. |
| P51608 | MECP2 | S13 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51965 | UBE2E1 | S13 | ochoa | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050). {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| P52298 | NCBP2 | S13 | ochoa | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17363367, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:26382858}. |
| P52943 | CRIP2 | Y13 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P53999 | SUB1 | S13 | ochoa | Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275, ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453, ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392, ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}. |
| P55072 | VCP | S13 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56693 | SOX10 | S13 | ochoa | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P57086 | SCAND1 | S13 | ochoa | SCAN domain-containing protein 1 | May regulate transcriptional activity. |
| P60468 | SEC61B | S13 | ochoa | Protein transport protein Sec61 subunit beta | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
| P62888 | RPL30 | S13 | ochoa | Large ribosomal subunit protein eL30 (60S ribosomal protein L30) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P78563 | ADARB1 | S13 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| P84098 | RPL19 | S13 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00534 | CDK6 | Y13 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q00613 | HSF1 | S13 | psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01543 | FLI1 | S13 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q01629 | IFITM2 | S13 | ochoa | Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}. |
| Q01780 | EXOSC10 | S13 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q01959 | SLC6A3 | S13 | psp | Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:1406597, ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:19478460, ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0000269|PubMed:8302271}. |
| Q04695 | KRT17 | S13 | psp | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}. |
| Q05329 | GAD2 | S13 | psp | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) | Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}. |
| Q07108 | CD69 | S13 | ochoa | Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69) | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481). {ECO:0000250|UniProtKB:P37217, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:26296369, ECO:0000269|PubMed:34841721, ECO:0000269|PubMed:35930205, ECO:0000269|PubMed:37039481}. |
| Q12797 | ASPH | S13 | ochoa | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}. |
| Q12852 | MAP3K12 | S13 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q13451 | FKBP5 | S13 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q13496 | MTM1 | S13 | ochoa | Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}. |
| Q13794 | PMAIP1 | S13 | ochoa|psp | Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa) | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}. |
| Q13838 | DDX39B | Y13 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14134 | TRIM29 | S13 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14135 | VGLL4 | S13 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14451 | GRB7 | S13 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14566 | MCM6 | S13 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q15021 | NCAPD2 | S13 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15040 | JOSD1 | S13 | ochoa | Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1) | Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}. |
| Q15056 | EIF4H | S13 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15173 | PPP2R5B | S13 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}. |
| Q15257 | PTPA | S13 | ochoa | Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B') | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320). {ECO:0000250|UniProtKB:Q28717, ECO:0000269|PubMed:16916641, ECO:0000269|PubMed:17333320, ECO:0000269|PubMed:36073231}. |
| Q15311 | RALBP1 | S13 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15417 | CNN3 | S13 | ochoa | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q15428 | SF3A2 | S13 | ochoa | Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310}. |
| Q15942 | ZYX | S13 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16543 | CDC37 | S13 | ochoa|psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16566 | CAMK4 | S13 | psp | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q16836 | HADH | S13 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q16851 | UGP2 | S13 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q2M2Z5 | KIZ | S13 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q4G0W2 | DUSP28 | S13 | ochoa | Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48) | Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083). {ECO:0000269|PubMed:24531476, ECO:0000269|PubMed:29121083}. |
| Q4VC44 | FLYWCH1 | S13 | ochoa | FLYWCH-type zinc finger-containing protein 1 | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}. |
| Q5GH72 | XKR7 | S13 | ochoa | XK-related protein 7 | None |
| Q5T6S3 | PHF19 | S13 | ochoa | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q5VT52 | RPRD2 | S13 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VYS4 | MEDAG | S13 | ochoa | Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4) | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}. |
| Q6P1R3 | MSANTD2 | S13 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6Q0C0 | TRAF7 | S13 | ochoa | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}. |
| Q6ZU65 | UBN2 | S13 | ochoa | Ubinuclein-2 | None |
| Q75N03 | CBLL1 | S13 | ochoa | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. |
| Q75QN2 | INTS8 | S13 | ochoa | Integrator complex subunit 8 (Int8) (Protein kaonashi-1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:28542170, ECO:0000269|PubMed:32966759, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:38570683}. |
| Q7L7V1 | DHX32 | S13 | ochoa | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) | None |
| Q7Z7C8 | TAF8 | S13 | ochoa | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}. |
| Q86U86 | PBRM1 | S13 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VM9 | ZC3H18 | S13 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IUE0 | TGIF2LY | S13 | ochoa | Homeobox protein TGIF2LY (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, Y-linked) (TGIF-like on the Y) | May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX. |
| Q8IUE1 | TGIF2LX | S13 | ochoa | Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X) | May have a transcription role in testis. |
| Q8IVP5 | FUNDC1 | S13 | ochoa|psp | FUN14 domain-containing protein 1 | Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:33972548). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels (PubMed:33972548). Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria (PubMed:22267086, PubMed:24671035, PubMed:24746696, PubMed:27653272). Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia (PubMed:27145933, PubMed:33978709). Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy (PubMed:36828120). {ECO:0000269|PubMed:22267086, ECO:0000269|PubMed:24671035, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27653272, ECO:0000269|PubMed:33972548, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:36828120}. |
| Q8IZL8 | PELP1 | S13 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N201 | INTS1 | S13 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N5U6 | RNF10 | S13 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8N884 | CGAS | S13 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NB78 | KDM1B | S13 | ochoa | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}. |
| Q8NB90 | AFG2A | S13 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NCA9 | ZNF784 | S13 | ochoa | Zinc finger protein 784 | May be involved in transcriptional regulation. |
| Q8NEZ2 | VPS37A | S13 | ochoa | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
| Q8NFQ8 | TOR1AIP2 | S13 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8TAA3 | PSMA8 | S13 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q8TBC5 | ZSCAN18 | S13 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TCJ2 | STT3B | S13 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). STT3B is present in a small subset of OST complexes (OST-B) and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A (PubMed:19167329, PubMed:22607976, PubMed:31296534, PubMed:39509507). STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins (PubMed:19167329, PubMed:22607976, PubMed:39509507). Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:19167329, PubMed:22607976). Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976). {ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:31296534, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39509507}. |
| Q8TDD5 | MCOLN3 | S13 | ochoa | Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Also permeable to Mg(2+), Na(+) and K(+) (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151). {ECO:0000250|UniProtKB:Q8R4F0, ECO:0000269|PubMed:18369318, ECO:0000269|PubMed:19497048, ECO:0000269|PubMed:19522758, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:20378547, ECO:0000269|PubMed:21245134, ECO:0000269|PubMed:23469151, ECO:0000269|PubMed:29106414, ECO:0000305}. |
| Q8TE77 | SSH3 | S13 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8WUM4 | PDCD6IP | S13 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WVE0 | EEF1AKMT1 | S13 | ochoa | EEF1A lysine methyltransferase 1 (EC 2.1.1.-) (N(6)-adenine-specific DNA methyltransferase 2) (Protein-lysine N-methyltransferase N6AMT2) (eEF1A-KMT) | Protein N-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. {ECO:0000255|HAMAP-Rule:MF_03187, ECO:0000269|PubMed:26545399, ECO:0000269|PubMed:28663172}. |
| Q8WWH5 | TRUB1 | S13 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WXE1 | ATRIP | S13 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WYL5 | SSH1 | S13 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92536 | SLC7A6 | Y13 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
| Q92963 | RIT1 | S13 | ochoa | GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}. |
| Q93073 | SECISBP2L | S13 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q96B01 | RAD51AP1 | Y13 | ochoa | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}. |
| Q96B49 | TOMM6 | S13 | ochoa | Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog) | None |
| Q96C00 | ZBTB9 | S13 | ochoa | Zinc finger and BTB domain-containing protein 9 | May be involved in transcriptional regulation. |
| Q96CP2 | FLYWCH2 | S13 | ochoa | FLYWCH family member 2 | None |
| Q96D31 | ORAI1 | S13 | ochoa | Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) | Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable) (PubMed:16645049, PubMed:16733527, PubMed:16807233, PubMed:16921383, PubMed:19249086, PubMed:19706554, PubMed:23307288, PubMed:26956484, PubMed:28219928). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (PubMed:16582901, PubMed:17442569, PubMed:19182790, PubMed:20354224, PubMed:22641696, PubMed:26221052, PubMed:32415068, PubMed:33941685). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (PubMed:19622606, PubMed:32415068). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity) (PubMed:20887894). {ECO:0000250|UniProtKB:Q8BWG9, ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:20354224, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685, ECO:0000305|PubMed:16766533}.; FUNCTION: [Isoform alpha]: Pore-forming subunit of both CRAC and ARC channels. Couples Ca(2+) influx to NFAT-mediated transcriptional responses. {ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}.; FUNCTION: [Isoform beta]: Pore-forming subunit of CRAC channels exclusively. {ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}. |
| Q96FZ5 | CMTM7 | S13 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
| Q96GZ6 | SLC41A3 | S13 | ochoa | Solute carrier family 41 member 3 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane. {ECO:0000269|PubMed:27302215}. |
| Q96HU1 | SGSM3 | S13 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96LR5 | UBE2E2 | S13 | ochoa | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:9371400}. |
| Q96MH2 | HEXIM2 | S14 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96P20 | NLRP3 | Y13 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96PU5 | NEDD4L | S13 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96S94 | CCNL2 | S13 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
| Q99613 | EIF3C | S13 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99708 | RBBP8 | S13 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99986 | VRK1 | S13 | ochoa | Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) | Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (PubMed:14645249, PubMed:18617507, PubMed:19103756, PubMed:33076429). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (PubMed:31527692, PubMed:37179361). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (PubMed:21920476, PubMed:31090908, PubMed:31527692). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (PubMed:19103756). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336). Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425). Phosphorylates JUN (PubMed:31527692). {ECO:0000250|UniProtKB:Q80X41, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:21920476, ECO:0000269|PubMed:31090908, ECO:0000269|PubMed:31527692, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:37179361}. |
| Q9BQF6 | SENP7 | S13 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BRQ6 | CHCHD6 | S13 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BSF8 | BTBD10 | S13 | ochoa | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}. |
| Q9BTX7 | TTPAL | S13 | ochoa | Alpha-tocopherol transfer protein-like | May act as a protein that binds a hydrophobic ligand. {ECO:0000305}. |
| Q9BXB4 | OSBPL11 | S13 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9BZE0 | GLIS2 | S13 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9GZP8 | IMUP | S13 | ochoa | Immortalization up-regulated protein (Hepatocyte growth factor activator inhibitor type 2-related small protein) (H2RSP) (HAI-2-related small protein) | None |
| Q9H0C8 | ILKAP | S13 | ochoa | Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16) | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269|PubMed:14990992}. |
| Q9H0H3 | KLHL25 | S13 | ochoa | Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}. |
| Q9H1B7 | IRF2BPL | S13 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H1E3 | NUCKS1 | Y13 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2Y7 | ZNF106 | S13 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H6Q3 | SLA2 | S13 | ochoa | Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}. |
| Q9H992 | MARCHF7 | S13 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9H9P5 | UNKL | S13 | ochoa | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}. |
| Q9HB15 | KCNK12 | S13 | psp | Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2) | K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The homodimers are mainly retained in the endoplasmic reticulum compartment and may be targeted to the cell surface upon phosphorylation or other activation signals yet to be elucidated. {ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:25148687}. |
| Q9HC35 | EML4 | S13 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HC98 | NEK6 | S13 | ochoa | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}. |
| Q9NQC3 | RTN4 | S13 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQC7 | CYLD | S13 | ochoa | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NR30 | DDX21 | S13 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR48 | ASH1L | S13 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NUM4 | TMEM106B | S13 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NUV9 | GIMAP4 | S13 | ochoa | GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) | During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. {ECO:0000250, ECO:0000250|UniProtKB:Q99JY3}. |
| Q9NWZ5 | UCKL1 | S13 | ochoa | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}. |
| Q9NZV5 | SELENON | S13 | ochoa | Selenoprotein N (SelN) | [Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863, PubMed:19557870). {ECO:0000269|PubMed:18713863, ECO:0000269|PubMed:19557870, ECO:0000269|PubMed:25452428}.; FUNCTION: Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). {ECO:0000269|PubMed:21131290}. |
| Q9P1Y6 | PHRF1 | S13 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UEE5 | STK17A | S13 | ochoa | Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. |
| Q9UHB6 | LIMA1 | S13 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UIA0 | CYTH4 | S13 | ochoa | Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4) | Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269|PubMed:10652308}. |
| Q9UID3 | VPS51 | S13 | ochoa | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}. |
| Q9UK33 | ZNF580 | S13 | ochoa | Zinc finger protein 580 (LDL-induced EC protein) | Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}. |
| Q9UMX0 | UBQLN1 | S13 | ochoa | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}. |
| Q9UNH7 | SNX6 | S13 | ochoa | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
| Q9UPW6 | SATB2 | S13 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UQQ2 | SH2B3 | S13 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y210 | TRPC6 | S13 | psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2U8 | LEMD3 | S13 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y342 | PLLP | S13 | ochoa | Plasmolipin (Plasma membrane proteolipid) | Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (PubMed:34999972). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000269|PubMed:26002055, ECO:0000269|PubMed:34999972}. |
| Q9Y4W2 | LAS1L | S13 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5Z7 | HCFC2 | S13 | ochoa | Host cell factor 2 (HCF-2) (C2 factor) | None |
| Q9Y6G9 | DYNC1LI1 | S13 | ochoa | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
| Q9Y6Q9 | NCOA3 | S13 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P37837 | TALDO1 | S13 | Sugiyama | Transaldolase (EC 2.2.1.2) | Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q93092, ECO:0000269|PubMed:18687684, ECO:0000269|PubMed:8955144}. |
| Q14192 | FHL2 | S13 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| Q8TD19 | NEK9 | S13 | Sugiyama | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| P78417 | GSTO1 | S13 | Sugiyama | Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) | Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}. |
| P05388 | RPLP0 | Y13 | Sugiyama | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| P19784 | CSNK2A2 | Y13 | Sugiyama | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q8NHW5 | RPLP0P6 | Y13 | Sugiyama | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| Q15024 | EXOSC7 | Y13 | Sugiyama | Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Q96B26 | EXOSC8 | Y13 | Sugiyama | Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| P84103 | SRSF3 | Y13 | Sugiyama | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| Q96ST3 | SIN3A | Y13 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q9H0R8 | GABARAPL1 | Y13 | Sugiyama | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) | Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. |
| O43813 | LANCL1 | Y13 | Sugiyama | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}. |
| Q15746 | MYLK | S13 | ELM | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| P09497 | CLTB | S13 | SIGNOR|iPTMNet | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| O60563 | CCNT1 | Y13 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O94776 | MTA2 | Y13 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q13330 | MTA1 | Y13 | Sugiyama | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q9BTC8 | MTA3 | Y13 | Sugiyama | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q13422 | IKZF1 | S13 | SIGNOR | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q92797 | SYMPK | S13 | Sugiyama | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q13882 | PTK6 | Y13 | GPS6|EPSD | Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. {ECO:0000269|PubMed:20554524}.; FUNCTION: [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
| Q16654 | PDK4 | S13 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}. |
| Q6P2M8 | PNCK | S13 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}. |
| K7ENP7 | None | T13 | ochoa | INO80 complex subunit C | None |
| O60493 | SNX3 | T13 | ochoa | Sorting nexin-3 (Protein SDP3) | Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551). {ECO:0000250|UniProtKB:O70492, ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:18767904, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080, ECO:0000269|PubMed:24344282, ECO:0000305|PubMed:21725319}. |
| O60841 | EIF5B | T13 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60927 | PPP1R11 | T13 | ochoa | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}. |
| O75909 | CCNK | T13 | ochoa | Cyclin-K | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}. |
| O95140 | MFN2 | T13 | ochoa | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:Q80U63, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:19889647, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26085578, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28114303, ECO:0000305}. |
| O95562 | SFT2D2 | T13 | ochoa | Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) | May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}. |
| O95772 | STARD3NL | T13 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P06454 | PTMA | T13 | ochoa | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. |
| P11142 | HSPA8 | T13 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P15170 | GSPT1 | T13 | ochoa | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}. |
| P16989 | YBX3 | T13 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P35659 | DEK | T13 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P41743 | PRKCI | T13 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P43487 | RANBP1 | T13 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P50402 | EMD | T13 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50748 | KNTC1 | T13 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P52926 | HMGA2 | T13 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| P62877 | RBX1 | T13 | ochoa | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:11961546, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:22748924, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:32355176, PubMed:33417871, PubMed:38326650, PubMed:39504960, PubMed:39667934, PubMed:38316879). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex mediates ubiquitination of Pol II subunit POLR2A at 'Lys-1268', a critical TC-NER checkpoint (PubMed:32355176, PubMed:34526721). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35982156). Core component of a Cul9-RING ubiquitin ligase complex composed of CUL9 and RBX1, which mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). {ECO:0000269|PubMed:10230407, ECO:0000269|PubMed:10579999, ECO:0000269|PubMed:11027288, ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:33417871, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:35982156, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:38605244, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| P68400 | CSNK2A1 | T13 | psp | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| P68871 | HBB | T13 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Q01167 | FOXK2 | T13 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q05397 | PTK2 | T13 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06609 | RAD51 | T13 | ochoa|psp | DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:22325354, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:32640219). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:38459011). Recruited to resolve stalled replication forks during replication stress (PubMed:27797818, PubMed:31844045). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (PubMed:12442171, PubMed:24141787). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (PubMed:20413593). Also involved in interstrand cross-link repair (PubMed:26253028). {ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:38459011}. |
| Q4VCS5 | AMOT | T13 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5T0D9 | TPRG1L | T13 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q6PI98 | INO80C | T13 | ochoa | INO80 complex subunit C (IES6 homolog) (hIes6) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q7L8J4 | SH3BP5L | T13 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q8NFY9 | KBTBD8 | T13 | ochoa | Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}. |
| Q8WUM0 | NUP133 | T13 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVM7 | STAG1 | T13 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q92600 | CNOT9 | T13 | ochoa | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}. |
| Q93015 | NAA80 | T13 | ochoa | N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) | N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307, ECO:0000269|PubMed:30028079}. |
| Q96EC8 | YIPF6 | T13 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
| Q96S97 | MYADM | T13 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q9BQ67 | GRWD1 | T13 | ochoa | Glutamate-rich WD repeat-containing protein 1 | Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}. |
| Q9BZF1 | OSBPL8 | T13 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9NRY5 | FAM114A2 | T13 | ochoa | Protein FAM114A2 | None |
| Q9P2K5 | MYEF2 | T13 | ochoa | Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) | Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}. |
| Q9UJV9 | DDX41 | T13 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9Y2V2 | CARHSP1 | T13 | ochoa | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y3Q8 | TSC22D4 | T13 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y5Q3 | MAFB | T13 | ochoa | Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) | Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). {ECO:0000250|UniProtKB:P54841, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:27181683}. |
| O15234 | CASC3 | T13 | Sugiyama | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P41238 | APOBEC1 | T13 | Sugiyama | C->U-editing enzyme APOBEC-1 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic subunit 1) (APO1) (APOBEC-1) (Apolipoprotein B mRNA-editing enzyme 1) (EC 3.5.4.36) (HEPR) (mRNA(cytosine(6666)) deaminase 1) | Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). {ECO:0000250|UniProtKB:P51908, ECO:0000269|PubMed:11727199, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:30844405}. |
| P30622 | CLIP1 | T13 | PSP | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.456292e-07 | 6.610 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.704639e-07 | 6.568 |
| R-HSA-1640170 | Cell Cycle | 1.556166e-06 | 5.808 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.768802e-06 | 5.239 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 8.690841e-06 | 5.061 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.070831e-05 | 4.970 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.038277e-05 | 4.691 |
| R-HSA-9612973 | Autophagy | 2.076994e-05 | 4.683 |
| R-HSA-9663891 | Selective autophagy | 4.256967e-05 | 4.371 |
| R-HSA-68886 | M Phase | 1.224883e-04 | 3.912 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 1.676200e-04 | 3.776 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.639979e-04 | 3.785 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.914532e-04 | 3.718 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.365870e-04 | 3.626 |
| R-HSA-5205647 | Mitophagy | 2.388387e-04 | 3.622 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.507651e-04 | 3.601 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.683973e-04 | 3.571 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 4.461479e-04 | 3.351 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 3.738248e-04 | 3.427 |
| R-HSA-9697154 | Disorders of Nervous System Development | 3.738248e-04 | 3.427 |
| R-HSA-9005895 | Pervasive developmental disorders | 3.738248e-04 | 3.427 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.207092e-04 | 3.376 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.404510e-04 | 3.356 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.404510e-04 | 3.356 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.373395e-04 | 3.359 |
| R-HSA-74160 | Gene expression (Transcription) | 3.629162e-04 | 3.440 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.933810e-04 | 3.405 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.153132e-04 | 3.382 |
| R-HSA-68882 | Mitotic Anaphase | 4.776356e-04 | 3.321 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.976221e-04 | 3.303 |
| R-HSA-2262752 | Cellular responses to stress | 4.870799e-04 | 3.312 |
| R-HSA-1632852 | Macroautophagy | 5.284697e-04 | 3.277 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.490734e-04 | 3.188 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.306716e-04 | 3.200 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 8.247751e-04 | 3.084 |
| R-HSA-68962 | Activation of the pre-replicative complex | 9.952364e-04 | 3.002 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.002514e-03 | 2.999 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 8.568183e-04 | 3.067 |
| R-HSA-8953854 | Metabolism of RNA | 9.648813e-04 | 3.016 |
| R-HSA-69242 | S Phase | 7.880532e-04 | 3.103 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.530578e-04 | 3.021 |
| R-HSA-9675108 | Nervous system development | 8.678350e-04 | 3.062 |
| R-HSA-69206 | G1/S Transition | 7.729630e-04 | 3.112 |
| R-HSA-422475 | Axon guidance | 8.106766e-04 | 3.091 |
| R-HSA-447115 | Interleukin-12 family signaling | 9.790464e-04 | 3.009 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.023546e-03 | 2.990 |
| R-HSA-8849473 | PTK6 Expression | 1.242762e-03 | 2.906 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.412776e-03 | 2.850 |
| R-HSA-9930044 | Nuclear RNA decay | 1.412776e-03 | 2.850 |
| R-HSA-72187 | mRNA 3'-end processing | 1.696643e-03 | 2.770 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.636963e-03 | 2.786 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.696643e-03 | 2.770 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.422480e-03 | 2.847 |
| R-HSA-68877 | Mitotic Prometaphase | 1.752124e-03 | 2.756 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.636963e-03 | 2.786 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.754872e-03 | 2.756 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.426238e-03 | 2.846 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.754872e-03 | 2.756 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.174649e-03 | 2.663 |
| R-HSA-176974 | Unwinding of DNA | 2.083375e-03 | 2.681 |
| R-HSA-68875 | Mitotic Prophase | 2.113233e-03 | 2.675 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 2.609046e-03 | 2.584 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.609046e-03 | 2.584 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.540358e-03 | 2.595 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.544759e-03 | 2.594 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.615687e-03 | 2.582 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.153037e-03 | 2.501 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.368897e-03 | 2.473 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.436900e-03 | 2.464 |
| R-HSA-69239 | Synthesis of DNA | 3.650913e-03 | 2.438 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 3.888677e-03 | 2.410 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.925452e-03 | 2.406 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.028807e-03 | 2.395 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.028807e-03 | 2.395 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.288554e-03 | 2.368 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.651407e-03 | 2.332 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.651407e-03 | 2.332 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.436272e-03 | 2.265 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.412990e-03 | 2.267 |
| R-HSA-9675135 | Diseases of DNA repair | 5.609294e-03 | 2.251 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.692597e-03 | 2.245 |
| R-HSA-162906 | HIV Infection | 5.847349e-03 | 2.233 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.313487e-03 | 2.200 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.997658e-03 | 2.155 |
| R-HSA-1433559 | Regulation of KIT signaling | 6.422610e-03 | 2.192 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.598150e-03 | 2.181 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.795921e-03 | 2.168 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 7.030778e-03 | 2.153 |
| R-HSA-8876725 | Protein methylation | 7.440874e-03 | 2.128 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.583638e-03 | 2.120 |
| R-HSA-69190 | DNA strand elongation | 8.364191e-03 | 2.078 |
| R-HSA-8849472 | PTK6 Down-Regulation | 9.441224e-03 | 2.025 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 9.133890e-03 | 2.039 |
| R-HSA-69306 | DNA Replication | 9.899940e-03 | 2.004 |
| R-HSA-69481 | G2/M Checkpoints | 1.006545e-02 | 1.997 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.012991e-02 | 1.994 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.052363e-02 | 1.978 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 1.216616e-02 | 1.915 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.171518e-02 | 1.931 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.243062e-02 | 1.906 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.171518e-02 | 1.931 |
| R-HSA-381042 | PERK regulates gene expression | 1.171518e-02 | 1.931 |
| R-HSA-162587 | HIV Life Cycle | 1.136687e-02 | 1.944 |
| R-HSA-5688426 | Deubiquitination | 1.286181e-02 | 1.891 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.367177e-02 | 1.864 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.391384e-02 | 1.857 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.431765e-02 | 1.844 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.519183e-02 | 1.818 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.549332e-02 | 1.810 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.549332e-02 | 1.810 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.549332e-02 | 1.810 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.549332e-02 | 1.810 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.582446e-02 | 1.801 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.582446e-02 | 1.801 |
| R-HSA-72312 | rRNA processing | 1.678159e-02 | 1.775 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.697613e-02 | 1.770 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 1.850490e-02 | 1.733 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.943332e-02 | 1.711 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.943332e-02 | 1.711 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.054966e-02 | 1.687 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.073999e-02 | 1.683 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.105185e-02 | 1.677 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.485139e-02 | 1.605 |
| R-HSA-3371556 | Cellular response to heat stress | 2.320022e-02 | 1.635 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.378997e-02 | 1.624 |
| R-HSA-9907900 | Proteasome assembly | 2.351199e-02 | 1.629 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.209939e-02 | 1.656 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.381069e-02 | 1.623 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.209245e-02 | 1.656 |
| R-HSA-913531 | Interferon Signaling | 2.203543e-02 | 1.657 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.497822e-02 | 1.602 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.497822e-02 | 1.602 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.571815e-02 | 1.590 |
| R-HSA-75072 | mRNA Editing | 2.594197e-02 | 1.586 |
| R-HSA-201688 | WNT mediated activation of DVL | 2.594197e-02 | 1.586 |
| R-HSA-72766 | Translation | 2.609635e-02 | 1.583 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.701632e-02 | 1.568 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.886600e-02 | 1.540 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 3.004134e-02 | 1.522 |
| R-HSA-73893 | DNA Damage Bypass | 3.138629e-02 | 1.503 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.108137e-02 | 1.507 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.409444e-02 | 1.467 |
| R-HSA-5689603 | UCH proteinases | 3.129055e-02 | 1.505 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.340503e-02 | 1.476 |
| R-HSA-5689877 | Josephin domain DUBs | 3.004134e-02 | 1.522 |
| R-HSA-73614 | Pyrimidine salvage | 3.409444e-02 | 1.467 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.409444e-02 | 1.467 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 3.437882e-02 | 1.464 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 3.437882e-02 | 1.464 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 3.437882e-02 | 1.464 |
| R-HSA-4839744 | Signaling by APC mutants | 3.437882e-02 | 1.464 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.442381e-02 | 1.463 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 3.894306e-02 | 1.410 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 4.372305e-02 | 1.359 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 4.372305e-02 | 1.359 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 4.372305e-02 | 1.359 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 4.372305e-02 | 1.359 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 4.372305e-02 | 1.359 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.664663e-02 | 1.436 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.867505e-02 | 1.413 |
| R-HSA-72649 | Translation initiation complex formation | 4.063591e-02 | 1.391 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.838316e-02 | 1.416 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 4.039843e-02 | 1.394 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 3.894306e-02 | 1.410 |
| R-HSA-4839735 | Signaling by AXIN mutants | 3.894306e-02 | 1.410 |
| R-HSA-877312 | Regulation of IFNG signaling | 4.372305e-02 | 1.359 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.664663e-02 | 1.436 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.203620e-02 | 1.376 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 3.894306e-02 | 1.410 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 4.372305e-02 | 1.359 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.867505e-02 | 1.413 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.472429e-02 | 1.349 |
| R-HSA-6807070 | PTEN Regulation | 4.478270e-02 | 1.349 |
| R-HSA-72172 | mRNA Splicing | 4.479524e-02 | 1.349 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.487189e-02 | 1.348 |
| R-HSA-1500620 | Meiosis | 4.500962e-02 | 1.347 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.648692e-02 | 1.333 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.672382e-02 | 1.330 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.672382e-02 | 1.330 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.694550e-02 | 1.328 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 5.998326e-02 | 1.222 |
| R-HSA-5619081 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 5.998326e-02 | 1.222 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 5.998326e-02 | 1.222 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 5.998326e-02 | 1.222 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 5.998326e-02 | 1.222 |
| R-HSA-5578995 | Defective TPMT causes TPMT deficiency | 5.998326e-02 | 1.222 |
| R-HSA-5660724 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 5.998326e-02 | 1.222 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 5.998326e-02 | 1.222 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 7.916955e-02 | 1.101 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 7.916955e-02 | 1.101 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 7.916955e-02 | 1.101 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 7.916955e-02 | 1.101 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 7.916955e-02 | 1.101 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 7.916955e-02 | 1.101 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 7.916955e-02 | 1.101 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 7.916955e-02 | 1.101 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 7.916955e-02 | 1.101 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 7.916955e-02 | 1.101 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 7.916955e-02 | 1.101 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 5.925275e-02 | 1.227 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 7.049836e-02 | 1.152 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 7.049836e-02 | 1.152 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.780024e-02 | 1.321 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.082019e-02 | 1.294 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.713034e-02 | 1.243 |
| R-HSA-3371511 | HSF1 activation | 6.041808e-02 | 1.219 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 7.442194e-02 | 1.128 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.781571e-02 | 1.238 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.811493e-02 | 1.167 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 7.442194e-02 | 1.128 |
| R-HSA-156902 | Peptide chain elongation | 5.209673e-02 | 1.283 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.099369e-02 | 1.292 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 6.041808e-02 | 1.219 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 6.041808e-02 | 1.219 |
| R-HSA-8848021 | Signaling by PTK6 | 6.077397e-02 | 1.216 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.077397e-02 | 1.216 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 7.812889e-02 | 1.107 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.082019e-02 | 1.294 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.286300e-02 | 1.202 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 6.479263e-02 | 1.188 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 7.636089e-02 | 1.117 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.780024e-02 | 1.321 |
| R-HSA-4641258 | Degradation of DVL | 6.379251e-02 | 1.195 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 5.998326e-02 | 1.222 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 5.998326e-02 | 1.222 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 7.916955e-02 | 1.101 |
| R-HSA-75102 | C6 deamination of adenosine | 7.916955e-02 | 1.101 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 4.870814e-02 | 1.312 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 5.388803e-02 | 1.269 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 5.388803e-02 | 1.269 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 5.388803e-02 | 1.269 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 7.636089e-02 | 1.117 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.725225e-02 | 1.172 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 7.442194e-02 | 1.128 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.903456e-02 | 1.309 |
| R-HSA-9646399 | Aggrephagy | 7.442194e-02 | 1.128 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.182052e-02 | 1.209 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.828320e-02 | 1.166 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 7.442194e-02 | 1.128 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 7.049836e-02 | 1.152 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.780024e-02 | 1.321 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.393063e-02 | 1.268 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.835357e-02 | 1.106 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 7.442194e-02 | 1.128 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 7.442194e-02 | 1.128 |
| R-HSA-111933 | Calmodulin induced events | 6.041808e-02 | 1.219 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 5.998326e-02 | 1.222 |
| R-HSA-9675132 | Diseases of cellular response to stress | 7.916955e-02 | 1.101 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 7.916955e-02 | 1.101 |
| R-HSA-111997 | CaM pathway | 6.041808e-02 | 1.219 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 7.442194e-02 | 1.128 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.949871e-02 | 1.158 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 5.925275e-02 | 1.227 |
| R-HSA-9706369 | Negative regulation of FLT3 | 6.479263e-02 | 1.188 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.259193e-02 | 1.203 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.591395e-02 | 1.252 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.356585e-02 | 1.271 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.713034e-02 | 1.243 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 6.479263e-02 | 1.188 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 5.925275e-02 | 1.227 |
| R-HSA-212436 | Generic Transcription Pathway | 5.074391e-02 | 1.295 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.481148e-02 | 1.126 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.077397e-02 | 1.216 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.847637e-02 | 1.314 |
| R-HSA-1500931 | Cell-Cell communication | 4.828787e-02 | 1.316 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.082019e-02 | 1.294 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 7.079589e-02 | 1.150 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.947084e-02 | 1.100 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.977998e-02 | 1.098 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 8.191517e-02 | 1.087 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 8.191517e-02 | 1.087 |
| R-HSA-5632684 | Hedgehog 'on' state | 8.235080e-02 | 1.084 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 8.237151e-02 | 1.084 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.412693e-02 | 1.075 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 8.528163e-02 | 1.069 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 8.577919e-02 | 1.067 |
| R-HSA-111996 | Ca-dependent events | 8.577919e-02 | 1.067 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.642820e-02 | 1.063 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 1.163787e-01 | 0.934 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1.163787e-01 | 0.934 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 1.163787e-01 | 0.934 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 1.520887e-01 | 0.818 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 1.520887e-01 | 0.818 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.694003e-01 | 0.771 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.694003e-01 | 0.771 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.863596e-01 | 0.730 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.863596e-01 | 0.730 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.863596e-01 | 0.730 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.863596e-01 | 0.730 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 2.029736e-01 | 0.693 |
| R-HSA-196025 | Formation of annular gap junctions | 2.029736e-01 | 0.693 |
| R-HSA-9613354 | Lipophagy | 2.192494e-01 | 0.659 |
| R-HSA-190873 | Gap junction degradation | 2.192494e-01 | 0.659 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.192494e-01 | 0.659 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 9.480349e-02 | 1.023 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.351938e-01 | 0.629 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.279173e-01 | 0.893 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.488978e-01 | 0.827 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.488978e-01 | 0.827 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.560381e-01 | 0.807 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.560381e-01 | 0.807 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.632422e-01 | 0.787 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.019797e-01 | 0.991 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.019797e-01 | 0.991 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.705044e-01 | 0.768 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.062075e-01 | 0.974 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.778194e-01 | 0.750 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.778194e-01 | 0.750 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.925872e-01 | 0.715 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.283252e-01 | 0.892 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.283252e-01 | 0.892 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.329320e-01 | 0.876 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.329320e-01 | 0.876 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.329320e-01 | 0.876 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.075067e-01 | 0.683 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 2.075067e-01 | 0.683 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.423146e-01 | 0.847 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.470868e-01 | 0.832 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.666728e-01 | 0.778 |
| R-HSA-192823 | Viral mRNA Translation | 8.903678e-02 | 1.050 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.452378e-01 | 0.610 |
| R-HSA-167169 | HIV Transcription Elongation | 2.528262e-01 | 0.597 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.528262e-01 | 0.597 |
| R-HSA-3371568 | Attenuation phase | 2.528262e-01 | 0.597 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 2.029736e-01 | 0.693 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.292491e-01 | 0.640 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 1.344173e-01 | 0.872 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.604200e-01 | 0.584 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.242088e-01 | 0.906 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.233842e-01 | 0.651 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.283252e-01 | 0.892 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.000304e-01 | 0.699 |
| R-HSA-110320 | Translesion Synthesis by POLH | 8.852176e-02 | 1.053 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.237771e-01 | 0.907 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.238627e-01 | 0.650 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.238627e-01 | 0.650 |
| R-HSA-5693538 | Homology Directed Repair | 1.395120e-01 | 0.855 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 9.480349e-02 | 1.023 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.214826e-01 | 0.915 |
| R-HSA-912446 | Meiotic recombination | 1.237771e-01 | 0.907 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.694003e-01 | 0.771 |
| R-HSA-72200 | mRNA Editing: C to U Conversion | 1.863596e-01 | 0.730 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.705044e-01 | 0.768 |
| R-HSA-69236 | G1 Phase | 9.373392e-02 | 1.028 |
| R-HSA-69231 | Cyclin D associated events in G1 | 9.373392e-02 | 1.028 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.039040e-01 | 0.983 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.029736e-01 | 0.693 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.418268e-01 | 0.848 |
| R-HSA-9766229 | Degradation of CDH1 | 1.148641e-01 | 0.940 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 9.750278e-02 | 1.011 |
| R-HSA-167172 | Transcription of the HIV genome | 2.078641e-01 | 0.682 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 8.971932e-02 | 1.047 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.329320e-01 | 0.876 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.604200e-01 | 0.584 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.238627e-01 | 0.650 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 1.344173e-01 | 0.872 |
| R-HSA-888568 | GABA synthesis | 1.163787e-01 | 0.934 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 1.163787e-01 | 0.934 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 1.520887e-01 | 0.818 |
| R-HSA-75094 | Formation of the Editosome | 1.520887e-01 | 0.818 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 2.029736e-01 | 0.693 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.351938e-01 | 0.629 |
| R-HSA-9865881 | Complex III assembly | 1.279173e-01 | 0.893 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.488978e-01 | 0.827 |
| R-HSA-8949613 | Cristae formation | 1.488978e-01 | 0.827 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 9.782129e-02 | 1.010 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.778194e-01 | 0.750 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.851820e-01 | 0.732 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.375958e-01 | 0.861 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.300919e-01 | 0.638 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.400928e-01 | 0.620 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.351938e-01 | 0.629 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.078641e-01 | 0.682 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.921411e-01 | 0.716 |
| R-HSA-844456 | The NLRP3 inflammasome | 8.852176e-02 | 1.053 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 2.029736e-01 | 0.693 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 9.480349e-02 | 1.023 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 9.373392e-02 | 1.028 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.620199e-01 | 0.582 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.520887e-01 | 0.818 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 2.029736e-01 | 0.693 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.508136e-01 | 0.601 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.851820e-01 | 0.732 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.192895e-01 | 0.923 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.000304e-01 | 0.699 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.423146e-01 | 0.847 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 2.192494e-01 | 0.659 |
| R-HSA-354192 | Integrin signaling | 1.925872e-01 | 0.715 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 9.437394e-02 | 1.025 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.519105e-01 | 0.818 |
| R-HSA-8852135 | Protein ubiquitination | 2.455469e-01 | 0.610 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.767393e-01 | 0.753 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.613765e-01 | 0.792 |
| R-HSA-5578775 | Ion homeostasis | 1.470868e-01 | 0.832 |
| R-HSA-73894 | DNA Repair | 2.613695e-01 | 0.583 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.863596e-01 | 0.730 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 8.852176e-02 | 1.053 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 2.351938e-01 | 0.629 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 1.632422e-01 | 0.787 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.150119e-01 | 0.668 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.617053e-01 | 0.791 |
| R-HSA-191859 | snRNP Assembly | 1.617053e-01 | 0.791 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.705044e-01 | 0.768 |
| R-HSA-1474165 | Reproduction | 1.856776e-01 | 0.731 |
| R-HSA-622312 | Inflammasomes | 1.560381e-01 | 0.807 |
| R-HSA-1489509 | DAG and IP3 signaling | 9.782129e-02 | 1.010 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.075067e-01 | 0.683 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.452378e-01 | 0.610 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.978223e-01 | 0.704 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.225417e-01 | 0.653 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.207139e-01 | 0.918 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 9.782129e-02 | 1.010 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.237771e-01 | 0.907 |
| R-HSA-397014 | Muscle contraction | 2.056173e-01 | 0.687 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 8.852176e-02 | 1.053 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.705044e-01 | 0.768 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 1.344173e-01 | 0.872 |
| R-HSA-112311 | Neurotransmitter clearance | 1.705044e-01 | 0.768 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.225417e-01 | 0.653 |
| R-HSA-4641257 | Degradation of AXIN | 2.300919e-01 | 0.638 |
| R-HSA-112043 | PLC beta mediated events | 1.716848e-01 | 0.765 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.528262e-01 | 0.597 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.604200e-01 | 0.584 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.039221e-01 | 0.983 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.062429e-01 | 0.686 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.348313e-01 | 0.870 |
| R-HSA-195721 | Signaling by WNT | 1.253562e-01 | 0.902 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.459820e-01 | 0.836 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.143600e-01 | 0.942 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.075067e-01 | 0.683 |
| R-HSA-9711097 | Cellular response to starvation | 1.587939e-01 | 0.799 |
| R-HSA-4086400 | PCP/CE pathway | 1.039040e-01 | 0.983 |
| R-HSA-447041 | CHL1 interactions | 1.863596e-01 | 0.730 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.348313e-01 | 0.870 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.348313e-01 | 0.870 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.000304e-01 | 0.699 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.075067e-01 | 0.683 |
| R-HSA-169911 | Regulation of Apoptosis | 2.150119e-01 | 0.668 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.617053e-01 | 0.791 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.272223e-01 | 0.895 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.869692e-01 | 0.728 |
| R-HSA-112040 | G-protein mediated events | 2.025902e-01 | 0.693 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.320914e-01 | 0.634 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.978223e-01 | 0.704 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.320914e-01 | 0.634 |
| R-HSA-8956321 | Nucleotide salvage | 1.716848e-01 | 0.765 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.210913e-01 | 0.917 |
| R-HSA-5619084 | ABC transporter disorders | 2.620199e-01 | 0.582 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.192494e-01 | 0.659 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.452378e-01 | 0.610 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.400928e-01 | 0.620 |
| R-HSA-418346 | Platelet homeostasis | 2.277271e-01 | 0.643 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.292491e-01 | 0.640 |
| R-HSA-1266738 | Developmental Biology | 1.241802e-01 | 0.906 |
| R-HSA-111885 | Opioid Signalling | 2.147658e-01 | 0.668 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.185019e-01 | 0.661 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 2.192494e-01 | 0.659 |
| R-HSA-210990 | PECAM1 interactions | 2.508136e-01 | 0.601 |
| R-HSA-3295583 | TRP channels | 1.418268e-01 | 0.848 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.925872e-01 | 0.715 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 1.666728e-01 | 0.778 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.062734e-01 | 0.974 |
| R-HSA-9909396 | Circadian clock | 1.926878e-01 | 0.715 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.093827e-01 | 0.961 |
| R-HSA-162582 | Signal Transduction | 1.426935e-01 | 0.846 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.376585e-01 | 0.624 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.666728e-01 | 0.778 |
| R-HSA-4839726 | Chromatin organization | 1.946957e-01 | 0.711 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.393836e-01 | 0.856 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.474935e-01 | 0.831 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 2.192494e-01 | 0.659 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.105029e-01 | 0.957 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.074496e-01 | 0.683 |
| R-HSA-168255 | Influenza Infection | 1.181264e-01 | 0.928 |
| R-HSA-351202 | Metabolism of polyamines | 1.666728e-01 | 0.778 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.528262e-01 | 0.597 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.604200e-01 | 0.584 |
| R-HSA-9824446 | Viral Infection Pathways | 1.092994e-01 | 0.961 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.059912e-01 | 0.686 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.351938e-01 | 0.629 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.077301e-01 | 0.968 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.400928e-01 | 0.620 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.936524e-01 | 0.713 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.085041e-01 | 0.681 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.426259e-01 | 0.846 |
| R-HSA-373755 | Semaphorin interactions | 1.818347e-01 | 0.740 |
| R-HSA-2672351 | Stimuli-sensing channels | 2.364761e-01 | 0.626 |
| R-HSA-445144 | Signal transduction by L1 | 9.480349e-02 | 1.023 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.925872e-01 | 0.715 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.075067e-01 | 0.683 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.853980e-01 | 0.732 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.365756e-01 | 0.865 |
| R-HSA-446728 | Cell junction organization | 9.221991e-02 | 1.035 |
| R-HSA-8853659 | RET signaling | 2.225417e-01 | 0.653 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.488978e-01 | 0.827 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.074496e-01 | 0.683 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.074496e-01 | 0.683 |
| R-HSA-421270 | Cell-cell junction organization | 1.113874e-01 | 0.953 |
| R-HSA-5357801 | Programmed Cell Death | 9.699015e-02 | 1.013 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.000304e-01 | 0.699 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.225417e-01 | 0.653 |
| R-HSA-418990 | Adherens junctions interactions | 1.222615e-01 | 0.913 |
| R-HSA-109581 | Apoptosis | 1.704591e-01 | 0.768 |
| R-HSA-9607240 | FLT3 Signaling | 2.604200e-01 | 0.584 |
| R-HSA-69541 | Stabilization of p53 | 2.452378e-01 | 0.610 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.470868e-01 | 0.832 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.528262e-01 | 0.597 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.851820e-01 | 0.732 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 1.488978e-01 | 0.827 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.300919e-01 | 0.638 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.645820e-01 | 0.784 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.661152e-01 | 0.575 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.661152e-01 | 0.575 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.661152e-01 | 0.575 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.671884e-01 | 0.573 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 2.680160e-01 | 0.572 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.680160e-01 | 0.572 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.722636e-01 | 0.565 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.730793e-01 | 0.564 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.767259e-01 | 0.558 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.786278e-01 | 0.555 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.789055e-01 | 0.555 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.811053e-01 | 0.551 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.811053e-01 | 0.551 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2.811053e-01 | 0.551 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.811053e-01 | 0.551 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.811053e-01 | 0.551 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 2.811053e-01 | 0.551 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.811053e-01 | 0.551 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.811053e-01 | 0.551 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.811053e-01 | 0.551 |
| R-HSA-73887 | Death Receptor Signaling | 2.828343e-01 | 0.548 |
| R-HSA-1280218 | Adaptive Immune System | 2.829764e-01 | 0.548 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.832015e-01 | 0.548 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.907850e-01 | 0.536 |
| R-HSA-373752 | Netrin-1 signaling | 2.907850e-01 | 0.536 |
| R-HSA-156581 | Methylation | 2.907850e-01 | 0.536 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.957901e-01 | 0.529 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.957901e-01 | 0.529 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.957901e-01 | 0.529 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.957901e-01 | 0.529 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.957901e-01 | 0.529 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.957901e-01 | 0.529 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.957901e-01 | 0.529 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 2.983584e-01 | 0.525 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.983584e-01 | 0.525 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.983584e-01 | 0.525 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.983584e-01 | 0.525 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.983584e-01 | 0.525 |
| R-HSA-9824272 | Somitogenesis | 2.983584e-01 | 0.525 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.986522e-01 | 0.525 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.009155e-01 | 0.522 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.037670e-01 | 0.517 |
| R-HSA-109582 | Hemostasis | 3.056418e-01 | 0.515 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.059190e-01 | 0.514 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.059190e-01 | 0.514 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.059190e-01 | 0.514 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.059190e-01 | 0.514 |
| R-HSA-75153 | Apoptotic execution phase | 3.059190e-01 | 0.514 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.066154e-01 | 0.513 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.075516e-01 | 0.512 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 3.101758e-01 | 0.508 |
| R-HSA-69166 | Removal of the Flap Intermediate | 3.101758e-01 | 0.508 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.101758e-01 | 0.508 |
| R-HSA-1170546 | Prolactin receptor signaling | 3.101758e-01 | 0.508 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 3.101758e-01 | 0.508 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 3.101758e-01 | 0.508 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.101758e-01 | 0.508 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 3.101758e-01 | 0.508 |
| R-HSA-391160 | Signal regulatory protein family interactions | 3.101758e-01 | 0.508 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 3.101758e-01 | 0.508 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.134641e-01 | 0.504 |
| R-HSA-1483191 | Synthesis of PC | 3.134641e-01 | 0.504 |
| R-HSA-70268 | Pyruvate metabolism | 3.176921e-01 | 0.498 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.209913e-01 | 0.494 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.226309e-01 | 0.491 |
| R-HSA-6805567 | Keratinization | 3.241100e-01 | 0.489 |
| R-HSA-9027284 | Erythropoietin activates RAS | 3.242685e-01 | 0.489 |
| R-HSA-418885 | DCC mediated attractive signaling | 3.242685e-01 | 0.489 |
| R-HSA-110312 | Translesion synthesis by REV1 | 3.242685e-01 | 0.489 |
| R-HSA-9857492 | Protein lipoylation | 3.242685e-01 | 0.489 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 3.242685e-01 | 0.489 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 3.242685e-01 | 0.489 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.242685e-01 | 0.489 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 3.242685e-01 | 0.489 |
| R-HSA-379401 | Dopamine clearance from the synaptic cleft | 3.242685e-01 | 0.489 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 3.242685e-01 | 0.489 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 3.242685e-01 | 0.489 |
| R-HSA-193639 | p75NTR signals via NF-kB | 3.242685e-01 | 0.489 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.284982e-01 | 0.483 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.284982e-01 | 0.483 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.287335e-01 | 0.483 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.288864e-01 | 0.483 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.380742e-01 | 0.471 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.380742e-01 | 0.471 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.380742e-01 | 0.471 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.380742e-01 | 0.471 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 3.380742e-01 | 0.471 |
| R-HSA-5635838 | Activation of SMO | 3.380742e-01 | 0.471 |
| R-HSA-9708530 | Regulation of BACH1 activity | 3.380742e-01 | 0.471 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 3.380742e-01 | 0.471 |
| R-HSA-9678110 | Attachment and Entry | 3.380742e-01 | 0.471 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.434419e-01 | 0.464 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.434419e-01 | 0.464 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.464907e-01 | 0.460 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.508743e-01 | 0.455 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.515986e-01 | 0.454 |
| R-HSA-6783984 | Glycine degradation | 3.515986e-01 | 0.454 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.515986e-01 | 0.454 |
| R-HSA-9927020 | Heme assimilation | 3.515986e-01 | 0.454 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 3.515986e-01 | 0.454 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.515986e-01 | 0.454 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 3.515986e-01 | 0.454 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.515986e-01 | 0.454 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.515986e-01 | 0.454 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.568379e-01 | 0.448 |
| R-HSA-1221632 | Meiotic synapsis | 3.582778e-01 | 0.446 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.582778e-01 | 0.446 |
| R-HSA-9843745 | Adipogenesis | 3.596848e-01 | 0.444 |
| R-HSA-5576891 | Cardiac conduction | 3.596848e-01 | 0.444 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.648475e-01 | 0.438 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.648475e-01 | 0.438 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.648475e-01 | 0.438 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.648475e-01 | 0.438 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.648475e-01 | 0.438 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.648475e-01 | 0.438 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.648475e-01 | 0.438 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.648475e-01 | 0.438 |
| R-HSA-2028269 | Signaling by Hippo | 3.648475e-01 | 0.438 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 3.648475e-01 | 0.438 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.778265e-01 | 0.423 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.778265e-01 | 0.423 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.778265e-01 | 0.423 |
| R-HSA-5358508 | Mismatch Repair | 3.778265e-01 | 0.423 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.778265e-01 | 0.423 |
| R-HSA-210993 | Tie2 Signaling | 3.778265e-01 | 0.423 |
| R-HSA-8951664 | Neddylation | 3.785137e-01 | 0.422 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.790911e-01 | 0.421 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.802960e-01 | 0.420 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.802960e-01 | 0.420 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.802960e-01 | 0.420 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.874885e-01 | 0.412 |
| R-HSA-5621480 | Dectin-2 family | 3.875655e-01 | 0.412 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.905411e-01 | 0.408 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.905411e-01 | 0.408 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 3.905411e-01 | 0.408 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.905411e-01 | 0.408 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.905411e-01 | 0.408 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.905411e-01 | 0.408 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.905411e-01 | 0.408 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.905411e-01 | 0.408 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.921105e-01 | 0.407 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.928153e-01 | 0.406 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.947973e-01 | 0.404 |
| R-HSA-70171 | Glycolysis | 4.011785e-01 | 0.397 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.019900e-01 | 0.396 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 4.029966e-01 | 0.395 |
| R-HSA-196108 | Pregnenolone biosynthesis | 4.029966e-01 | 0.395 |
| R-HSA-9629569 | Protein hydroxylation | 4.029966e-01 | 0.395 |
| R-HSA-6807004 | Negative regulation of MET activity | 4.029966e-01 | 0.395 |
| R-HSA-373753 | Nephrin family interactions | 4.029966e-01 | 0.395 |
| R-HSA-3322077 | Glycogen synthesis | 4.029966e-01 | 0.395 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.036580e-01 | 0.394 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.066674e-01 | 0.391 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 4.151983e-01 | 0.382 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.151983e-01 | 0.382 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.151983e-01 | 0.382 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 4.151983e-01 | 0.382 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.151983e-01 | 0.382 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 4.151983e-01 | 0.382 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 4.151983e-01 | 0.382 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 4.151983e-01 | 0.382 |
| R-HSA-210991 | Basigin interactions | 4.151983e-01 | 0.382 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.162525e-01 | 0.381 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.162525e-01 | 0.381 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.197175e-01 | 0.377 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.230416e-01 | 0.374 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.230416e-01 | 0.374 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.233196e-01 | 0.373 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.233196e-01 | 0.373 |
| R-HSA-1268020 | Mitochondrial protein import | 4.233196e-01 | 0.373 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.233196e-01 | 0.373 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.233196e-01 | 0.373 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.233196e-01 | 0.373 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.233196e-01 | 0.373 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.242926e-01 | 0.372 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.271513e-01 | 0.369 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 4.271513e-01 | 0.369 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.271513e-01 | 0.369 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.271513e-01 | 0.369 |
| R-HSA-175474 | Assembly Of The HIV Virion | 4.271513e-01 | 0.369 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.271513e-01 | 0.369 |
| R-HSA-9694614 | Attachment and Entry | 4.271513e-01 | 0.369 |
| R-HSA-983712 | Ion channel transport | 4.276789e-01 | 0.369 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.284661e-01 | 0.368 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.284661e-01 | 0.368 |
| R-HSA-6803529 | FGFR2 alternative splicing | 4.388608e-01 | 0.358 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.388608e-01 | 0.358 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.388608e-01 | 0.358 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.388608e-01 | 0.358 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 4.388608e-01 | 0.358 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 4.388608e-01 | 0.358 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.388608e-01 | 0.358 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.442504e-01 | 0.352 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.499761e-01 | 0.347 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.499761e-01 | 0.347 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.503316e-01 | 0.346 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.503316e-01 | 0.346 |
| R-HSA-3000170 | Syndecan interactions | 4.503316e-01 | 0.346 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.503316e-01 | 0.346 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.579682e-01 | 0.339 |
| R-HSA-202403 | TCR signaling | 4.606084e-01 | 0.337 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.615686e-01 | 0.336 |
| R-HSA-429947 | Deadenylation of mRNA | 4.615686e-01 | 0.336 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.615686e-01 | 0.336 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.615686e-01 | 0.336 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.615686e-01 | 0.336 |
| R-HSA-449147 | Signaling by Interleukins | 4.626619e-01 | 0.335 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.647535e-01 | 0.333 |
| R-HSA-5218859 | Regulated Necrosis | 4.647535e-01 | 0.333 |
| R-HSA-9609507 | Protein localization | 4.694741e-01 | 0.328 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.711519e-01 | 0.327 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.714885e-01 | 0.327 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.725766e-01 | 0.326 |
| R-HSA-420029 | Tight junction interactions | 4.725766e-01 | 0.326 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.725766e-01 | 0.326 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.725766e-01 | 0.326 |
| R-HSA-3214842 | HDMs demethylate histones | 4.725766e-01 | 0.326 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.726282e-01 | 0.325 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.739250e-01 | 0.324 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.781724e-01 | 0.320 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.781724e-01 | 0.320 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.816018e-01 | 0.317 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.833601e-01 | 0.316 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.833601e-01 | 0.316 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.833601e-01 | 0.316 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.833601e-01 | 0.316 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.833601e-01 | 0.316 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.848047e-01 | 0.314 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.871922e-01 | 0.312 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.913845e-01 | 0.309 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.939239e-01 | 0.306 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.939239e-01 | 0.306 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.939239e-01 | 0.306 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.939239e-01 | 0.306 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.939239e-01 | 0.306 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.939239e-01 | 0.306 |
| R-HSA-201451 | Signaling by BMP | 4.939239e-01 | 0.306 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.939239e-01 | 0.306 |
| R-HSA-877300 | Interferon gamma signaling | 4.959617e-01 | 0.305 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.979112e-01 | 0.303 |
| R-HSA-168256 | Immune System | 4.985493e-01 | 0.302 |
| R-HSA-597592 | Post-translational protein modification | 5.003300e-01 | 0.301 |
| R-HSA-373760 | L1CAM interactions | 5.022029e-01 | 0.299 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 5.042723e-01 | 0.297 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 5.042723e-01 | 0.297 |
| R-HSA-77387 | Insulin receptor recycling | 5.042723e-01 | 0.297 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 5.042723e-01 | 0.297 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.043844e-01 | 0.297 |
| R-HSA-70326 | Glucose metabolism | 5.072880e-01 | 0.295 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.072880e-01 | 0.295 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.108033e-01 | 0.292 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.108033e-01 | 0.292 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 5.144097e-01 | 0.289 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 5.144097e-01 | 0.289 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 5.144097e-01 | 0.289 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.144097e-01 | 0.289 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 5.144097e-01 | 0.289 |
| R-HSA-72086 | mRNA Capping | 5.144097e-01 | 0.289 |
| R-HSA-180024 | DARPP-32 events | 5.144097e-01 | 0.289 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 5.144097e-01 | 0.289 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.234769e-01 | 0.281 |
| R-HSA-2424491 | DAP12 signaling | 5.243404e-01 | 0.280 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.243404e-01 | 0.280 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.243404e-01 | 0.280 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.243404e-01 | 0.280 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 5.243404e-01 | 0.280 |
| R-HSA-9679506 | SARS-CoV Infections | 5.259437e-01 | 0.279 |
| R-HSA-392499 | Metabolism of proteins | 5.295739e-01 | 0.276 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.297306e-01 | 0.276 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.340686e-01 | 0.272 |
| R-HSA-5694530 | Cargo concentration in the ER | 5.340686e-01 | 0.272 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 5.340686e-01 | 0.272 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.340686e-01 | 0.272 |
| R-HSA-186763 | Downstream signal transduction | 5.340686e-01 | 0.272 |
| R-HSA-6806834 | Signaling by MET | 5.420700e-01 | 0.266 |
| R-HSA-9833482 | PKR-mediated signaling | 5.420700e-01 | 0.266 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.435985e-01 | 0.265 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.470776e-01 | 0.262 |
| R-HSA-5663205 | Infectious disease | 5.472724e-01 | 0.262 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.512904e-01 | 0.259 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.517873e-01 | 0.258 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.517873e-01 | 0.258 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.517873e-01 | 0.258 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.529340e-01 | 0.257 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.529340e-01 | 0.257 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.529340e-01 | 0.257 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.541835e-01 | 0.256 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.601549e-01 | 0.252 |
| R-HSA-390522 | Striated Muscle Contraction | 5.620791e-01 | 0.250 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.620791e-01 | 0.250 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 5.620791e-01 | 0.250 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.636026e-01 | 0.249 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.660692e-01 | 0.247 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.710377e-01 | 0.243 |
| R-HSA-5365859 | RA biosynthesis pathway | 5.710377e-01 | 0.243 |
| R-HSA-5673000 | RAF activation | 5.710377e-01 | 0.243 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.710377e-01 | 0.243 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.719261e-01 | 0.243 |
| R-HSA-187687 | Signalling to ERKs | 5.798136e-01 | 0.237 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.798136e-01 | 0.237 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.798136e-01 | 0.237 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.834674e-01 | 0.234 |
| R-HSA-2559583 | Cellular Senescence | 5.876635e-01 | 0.231 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.884104e-01 | 0.230 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 5.884104e-01 | 0.230 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.884104e-01 | 0.230 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.891516e-01 | 0.230 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.968319e-01 | 0.224 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.968319e-01 | 0.224 |
| R-HSA-8875878 | MET promotes cell motility | 6.050816e-01 | 0.218 |
| R-HSA-74217 | Purine salvage | 6.050816e-01 | 0.218 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.058582e-01 | 0.218 |
| R-HSA-202424 | Downstream TCR signaling | 6.058582e-01 | 0.218 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.116773e-01 | 0.213 |
| R-HSA-8939211 | ESR-mediated signaling | 6.119750e-01 | 0.213 |
| R-HSA-71336 | Pentose phosphate pathway | 6.131630e-01 | 0.212 |
| R-HSA-201556 | Signaling by ALK | 6.131630e-01 | 0.212 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.167076e-01 | 0.210 |
| R-HSA-202433 | Generation of second messenger molecules | 6.210795e-01 | 0.207 |
| R-HSA-8982491 | Glycogen metabolism | 6.210795e-01 | 0.207 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.220459e-01 | 0.206 |
| R-HSA-391251 | Protein folding | 6.220459e-01 | 0.206 |
| R-HSA-157118 | Signaling by NOTCH | 6.221263e-01 | 0.206 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 6.288345e-01 | 0.201 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 6.288345e-01 | 0.201 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.288345e-01 | 0.201 |
| R-HSA-9694548 | Maturation of spike protein | 6.288345e-01 | 0.201 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 6.288345e-01 | 0.201 |
| R-HSA-1483257 | Phospholipid metabolism | 6.323020e-01 | 0.199 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.364312e-01 | 0.196 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 6.364312e-01 | 0.196 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.364312e-01 | 0.196 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 6.364312e-01 | 0.196 |
| R-HSA-9683701 | Translation of Structural Proteins | 6.364312e-01 | 0.196 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.377168e-01 | 0.195 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.389152e-01 | 0.195 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.438729e-01 | 0.191 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.478785e-01 | 0.189 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.498822e-01 | 0.187 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.528743e-01 | 0.185 |
| R-HSA-2172127 | DAP12 interactions | 6.583038e-01 | 0.182 |
| R-HSA-190828 | Gap junction trafficking | 6.583038e-01 | 0.182 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.583038e-01 | 0.182 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.583038e-01 | 0.182 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.620012e-01 | 0.179 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.620085e-01 | 0.179 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.652991e-01 | 0.177 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.721516e-01 | 0.173 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.721516e-01 | 0.173 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.721516e-01 | 0.173 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.721516e-01 | 0.173 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.721516e-01 | 0.173 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.721516e-01 | 0.173 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.721516e-01 | 0.173 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.721516e-01 | 0.173 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.723336e-01 | 0.172 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 6.723336e-01 | 0.172 |
| R-HSA-1483255 | PI Metabolism | 6.770103e-01 | 0.169 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.788642e-01 | 0.168 |
| R-HSA-1643685 | Disease | 6.801766e-01 | 0.167 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.815388e-01 | 0.167 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.918811e-01 | 0.160 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.918811e-01 | 0.160 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 6.918811e-01 | 0.160 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.918811e-01 | 0.160 |
| R-HSA-1989781 | PPARA activates gene expression | 6.928495e-01 | 0.159 |
| R-HSA-9748787 | Azathioprine ADME | 6.981909e-01 | 0.156 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.981909e-01 | 0.156 |
| R-HSA-9610379 | HCMV Late Events | 7.002208e-01 | 0.155 |
| R-HSA-211000 | Gene Silencing by RNA | 7.041538e-01 | 0.152 |
| R-HSA-2514856 | The phototransduction cascade | 7.043719e-01 | 0.152 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 7.104267e-01 | 0.148 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 7.104267e-01 | 0.148 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 7.104267e-01 | 0.148 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.111492e-01 | 0.148 |
| R-HSA-8956320 | Nucleotide biosynthesis | 7.163579e-01 | 0.145 |
| R-HSA-156588 | Glucuronidation | 7.221679e-01 | 0.141 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.253025e-01 | 0.139 |
| R-HSA-199991 | Membrane Trafficking | 7.273371e-01 | 0.138 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 7.278592e-01 | 0.138 |
| R-HSA-418597 | G alpha (z) signalling events | 7.278592e-01 | 0.138 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.278592e-01 | 0.138 |
| R-HSA-75893 | TNF signaling | 7.334344e-01 | 0.135 |
| R-HSA-5619102 | SLC transporter disorders | 7.350691e-01 | 0.134 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.388956e-01 | 0.131 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.441403e-01 | 0.128 |
| R-HSA-9658195 | Leishmania infection | 7.441403e-01 | 0.128 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 7.442453e-01 | 0.128 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 7.442453e-01 | 0.128 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.451615e-01 | 0.128 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.451615e-01 | 0.128 |
| R-HSA-180786 | Extension of Telomeres | 7.494857e-01 | 0.125 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.526874e-01 | 0.123 |
| R-HSA-156590 | Glutathione conjugation | 7.546190e-01 | 0.122 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.546190e-01 | 0.122 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.546190e-01 | 0.122 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.546190e-01 | 0.122 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.546190e-01 | 0.122 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.546190e-01 | 0.122 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.636345e-01 | 0.117 |
| R-HSA-9707616 | Heme signaling | 7.645732e-01 | 0.117 |
| R-HSA-186797 | Signaling by PDGF | 7.645732e-01 | 0.117 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.741248e-01 | 0.111 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.741248e-01 | 0.111 |
| R-HSA-15869 | Metabolism of nucleotides | 7.741351e-01 | 0.111 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.743767e-01 | 0.111 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.743767e-01 | 0.111 |
| R-HSA-194138 | Signaling by VEGF | 7.845569e-01 | 0.105 |
| R-HSA-196071 | Metabolism of steroid hormones | 7.877325e-01 | 0.104 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.878598e-01 | 0.104 |
| R-HSA-69275 | G2/M Transition | 7.951056e-01 | 0.100 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.004371e-01 | 0.097 |
| R-HSA-204005 | COPII-mediated vesicle transport | 8.005227e-01 | 0.097 |
| R-HSA-9638482 | Metal ion assimilation from the host | 8.046130e-01 | 0.094 |
| R-HSA-9609646 | HCMV Infection | 8.081219e-01 | 0.093 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.097567e-01 | 0.092 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 8.125445e-01 | 0.090 |
| R-HSA-4086398 | Ca2+ pathway | 8.125445e-01 | 0.090 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.127154e-01 | 0.090 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.163890e-01 | 0.088 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.201549e-01 | 0.086 |
| R-HSA-9609690 | HCMV Early Events | 8.206156e-01 | 0.086 |
| R-HSA-1980143 | Signaling by NOTCH1 | 8.238438e-01 | 0.084 |
| R-HSA-163685 | Integration of energy metabolism | 8.241439e-01 | 0.084 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.274572e-01 | 0.082 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.344639e-01 | 0.079 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 8.344639e-01 | 0.079 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.345893e-01 | 0.079 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.349434e-01 | 0.078 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.349434e-01 | 0.078 |
| R-HSA-9664407 | Parasite infection | 8.349434e-01 | 0.078 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.358496e-01 | 0.078 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.375482e-01 | 0.077 |
| R-HSA-5654738 | Signaling by FGFR2 | 8.378601e-01 | 0.077 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.411869e-01 | 0.075 |
| R-HSA-9758941 | Gastrulation | 8.593705e-01 | 0.066 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.597658e-01 | 0.066 |
| R-HSA-438064 | Post NMDA receptor activation events | 8.626444e-01 | 0.064 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.654640e-01 | 0.063 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.660285e-01 | 0.062 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.666224e-01 | 0.062 |
| R-HSA-73884 | Base Excision Repair | 8.709313e-01 | 0.060 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.735813e-01 | 0.059 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.760635e-01 | 0.057 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.787197e-01 | 0.056 |
| R-HSA-2029481 | FCGR activation | 8.812102e-01 | 0.055 |
| R-HSA-382551 | Transport of small molecules | 8.825711e-01 | 0.054 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.836498e-01 | 0.054 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.860394e-01 | 0.053 |
| R-HSA-2168880 | Scavenging of heme from plasma | 8.883801e-01 | 0.051 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.906728e-01 | 0.050 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.906728e-01 | 0.050 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.906728e-01 | 0.050 |
| R-HSA-157579 | Telomere Maintenance | 8.929186e-01 | 0.049 |
| R-HSA-422356 | Regulation of insulin secretion | 8.951184e-01 | 0.048 |
| R-HSA-190236 | Signaling by FGFR | 8.951184e-01 | 0.048 |
| R-HSA-3214847 | HATs acetylate histones | 8.972732e-01 | 0.047 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.972732e-01 | 0.047 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.002025e-01 | 0.046 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.014511e-01 | 0.045 |
| R-HSA-72306 | tRNA processing | 9.018985e-01 | 0.045 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.030484e-01 | 0.044 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.034761e-01 | 0.044 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 9.034761e-01 | 0.044 |
| R-HSA-418555 | G alpha (s) signalling events | 9.035136e-01 | 0.044 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.066698e-01 | 0.043 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.066698e-01 | 0.043 |
| R-HSA-9833110 | RSV-host interactions | 9.093056e-01 | 0.041 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.123754e-01 | 0.040 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.129956e-01 | 0.040 |
| R-HSA-611105 | Respiratory electron transport | 9.141436e-01 | 0.039 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.247707e-01 | 0.034 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.307712e-01 | 0.031 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.321949e-01 | 0.030 |
| R-HSA-416476 | G alpha (q) signalling events | 9.329258e-01 | 0.030 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.349563e-01 | 0.029 |
| R-HSA-112316 | Neuronal System | 9.387537e-01 | 0.027 |
| R-HSA-73886 | Chromosome Maintenance | 9.388891e-01 | 0.027 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.413783e-01 | 0.026 |
| R-HSA-114608 | Platelet degranulation | 9.471680e-01 | 0.024 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.482556e-01 | 0.023 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.503644e-01 | 0.022 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.515840e-01 | 0.022 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.526895e-01 | 0.021 |
| R-HSA-2187338 | Visual phototransduction | 9.672679e-01 | 0.014 |
| R-HSA-166520 | Signaling by NTRKs | 9.679427e-01 | 0.014 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.679427e-01 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.688288e-01 | 0.014 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.692510e-01 | 0.014 |
| R-HSA-6798695 | Neutrophil degranulation | 9.696657e-01 | 0.013 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.717515e-01 | 0.012 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.736550e-01 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 9.772716e-01 | 0.010 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.871974e-01 | 0.006 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.900370e-01 | 0.004 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.911322e-01 | 0.004 |
| R-HSA-9748784 | Drug ADME | 9.928706e-01 | 0.003 |
| R-HSA-8957322 | Metabolism of steroids | 9.936502e-01 | 0.003 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.943370e-01 | 0.002 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.944544e-01 | 0.002 |
| R-HSA-168249 | Innate Immune System | 9.955695e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.974036e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.986858e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.991026e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.991154e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.992333e-01 | 0.000 |
| R-HSA-1474244 | Extracellular matrix organization | 9.993356e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.996689e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999546e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.896 | 0.410 | 1 | 0.867 |
COT |
0.886 | 0.211 | 2 | 0.853 |
MOS |
0.886 | 0.274 | 1 | 0.854 |
CDC7 |
0.878 | 0.156 | 1 | 0.837 |
NLK |
0.877 | 0.233 | 1 | 0.867 |
PIM3 |
0.876 | 0.165 | -3 | 0.864 |
HIPK4 |
0.875 | 0.302 | 1 | 0.814 |
PRPK |
0.874 | -0.031 | -1 | 0.842 |
ERK5 |
0.874 | 0.211 | 1 | 0.868 |
JNK2 |
0.874 | 0.337 | 1 | 0.750 |
CDKL1 |
0.874 | 0.153 | -3 | 0.824 |
GRK1 |
0.873 | 0.249 | -2 | 0.819 |
BMPR1B |
0.873 | 0.239 | 1 | 0.813 |
MTOR |
0.873 | 0.109 | 1 | 0.793 |
SRPK1 |
0.873 | 0.238 | -3 | 0.783 |
DYRK2 |
0.872 | 0.324 | 1 | 0.796 |
ICK |
0.871 | 0.223 | -3 | 0.859 |
SKMLCK |
0.871 | 0.166 | -2 | 0.905 |
JNK3 |
0.870 | 0.307 | 1 | 0.776 |
CAMK1B |
0.869 | 0.052 | -3 | 0.869 |
BMPR2 |
0.869 | -0.075 | -2 | 0.887 |
CDKL5 |
0.869 | 0.185 | -3 | 0.814 |
KIS |
0.869 | 0.328 | 1 | 0.799 |
CLK2 |
0.868 | 0.337 | -3 | 0.779 |
P38B |
0.868 | 0.326 | 1 | 0.774 |
CDK1 |
0.868 | 0.295 | 1 | 0.764 |
HIPK2 |
0.867 | 0.349 | 1 | 0.733 |
GRK7 |
0.867 | 0.194 | 1 | 0.756 |
CAMK2G |
0.867 | 0.021 | 2 | 0.827 |
ATR |
0.867 | -0.007 | 1 | 0.766 |
RAF1 |
0.866 | -0.076 | 1 | 0.788 |
CAMLCK |
0.866 | 0.083 | -2 | 0.882 |
PIM1 |
0.866 | 0.149 | -3 | 0.809 |
P38A |
0.865 | 0.298 | 1 | 0.816 |
HIPK1 |
0.865 | 0.311 | 1 | 0.807 |
NDR2 |
0.865 | 0.126 | -3 | 0.869 |
DAPK2 |
0.865 | 0.075 | -3 | 0.875 |
DSTYK |
0.865 | -0.001 | 2 | 0.881 |
NIK |
0.864 | -0.027 | -3 | 0.884 |
TGFBR1 |
0.863 | 0.121 | -2 | 0.808 |
P38G |
0.863 | 0.296 | 1 | 0.697 |
GRK5 |
0.863 | -0.014 | -3 | 0.873 |
RSK2 |
0.863 | 0.144 | -3 | 0.792 |
GRK6 |
0.863 | 0.079 | 1 | 0.805 |
CDK5 |
0.863 | 0.278 | 1 | 0.799 |
CDK8 |
0.863 | 0.260 | 1 | 0.774 |
LATS1 |
0.863 | 0.144 | -3 | 0.883 |
IKKB |
0.862 | -0.024 | -2 | 0.758 |
CDK18 |
0.861 | 0.304 | 1 | 0.738 |
PRKD1 |
0.861 | 0.147 | -3 | 0.837 |
CLK4 |
0.861 | 0.232 | -3 | 0.790 |
PDHK4 |
0.860 | -0.238 | 1 | 0.807 |
PKN3 |
0.860 | 0.019 | -3 | 0.844 |
ERK1 |
0.860 | 0.279 | 1 | 0.762 |
DYRK4 |
0.860 | 0.324 | 1 | 0.753 |
MST4 |
0.858 | 0.042 | 2 | 0.840 |
ALK4 |
0.858 | 0.035 | -2 | 0.836 |
SRPK3 |
0.858 | 0.160 | -3 | 0.757 |
ALK2 |
0.858 | 0.113 | -2 | 0.817 |
CDK7 |
0.858 | 0.243 | 1 | 0.790 |
SRPK2 |
0.858 | 0.191 | -3 | 0.704 |
CHAK2 |
0.858 | -0.015 | -1 | 0.802 |
TBK1 |
0.858 | -0.101 | 1 | 0.680 |
CAMK2B |
0.857 | 0.131 | 2 | 0.816 |
CDK19 |
0.857 | 0.266 | 1 | 0.747 |
NUAK2 |
0.857 | 0.032 | -3 | 0.857 |
PRP4 |
0.857 | 0.210 | -3 | 0.798 |
CAMK2D |
0.857 | 0.047 | -3 | 0.839 |
CDK3 |
0.856 | 0.269 | 1 | 0.717 |
P90RSK |
0.856 | 0.090 | -3 | 0.800 |
CAMK2A |
0.856 | 0.137 | 2 | 0.831 |
WNK1 |
0.856 | -0.023 | -2 | 0.906 |
DLK |
0.856 | -0.122 | 1 | 0.779 |
IKKA |
0.856 | 0.046 | -2 | 0.752 |
P38D |
0.856 | 0.304 | 1 | 0.704 |
NEK6 |
0.856 | -0.031 | -2 | 0.866 |
NDR1 |
0.855 | 0.031 | -3 | 0.851 |
MLK1 |
0.855 | -0.102 | 2 | 0.788 |
CLK1 |
0.855 | 0.229 | -3 | 0.759 |
CDK13 |
0.855 | 0.232 | 1 | 0.768 |
IKKE |
0.855 | -0.100 | 1 | 0.677 |
ACVR2B |
0.855 | 0.091 | -2 | 0.802 |
MARK4 |
0.855 | 0.018 | 4 | 0.826 |
PKCD |
0.854 | 0.046 | 2 | 0.763 |
CDK17 |
0.854 | 0.268 | 1 | 0.698 |
PKR |
0.854 | -0.027 | 1 | 0.765 |
MAK |
0.854 | 0.335 | -2 | 0.817 |
PDHK1 |
0.854 | -0.251 | 1 | 0.785 |
P70S6KB |
0.853 | 0.057 | -3 | 0.807 |
GCN2 |
0.853 | -0.156 | 2 | 0.776 |
TGFBR2 |
0.853 | -0.055 | -2 | 0.801 |
PKN2 |
0.853 | 0.008 | -3 | 0.846 |
AURC |
0.853 | 0.155 | -2 | 0.702 |
MLK2 |
0.853 | -0.084 | 2 | 0.795 |
AMPKA1 |
0.852 | 0.003 | -3 | 0.862 |
ULK2 |
0.852 | -0.196 | 2 | 0.747 |
DYRK1B |
0.852 | 0.273 | 1 | 0.764 |
PRKD2 |
0.852 | 0.110 | -3 | 0.784 |
DYRK1A |
0.852 | 0.240 | 1 | 0.814 |
BMPR1A |
0.852 | 0.153 | 1 | 0.793 |
RSK4 |
0.852 | 0.149 | -3 | 0.777 |
RIPK3 |
0.852 | -0.107 | 3 | 0.681 |
MAPKAPK2 |
0.852 | 0.108 | -3 | 0.746 |
FAM20C |
0.852 | 0.174 | 2 | 0.677 |
VRK2 |
0.851 | -0.135 | 1 | 0.823 |
RSK3 |
0.851 | 0.083 | -3 | 0.783 |
ACVR2A |
0.851 | 0.051 | -2 | 0.789 |
MEK1 |
0.851 | -0.131 | 2 | 0.820 |
HIPK3 |
0.850 | 0.250 | 1 | 0.793 |
MASTL |
0.850 | -0.233 | -2 | 0.826 |
NEK7 |
0.850 | -0.177 | -3 | 0.851 |
PASK |
0.850 | 0.119 | -3 | 0.884 |
CDK12 |
0.850 | 0.235 | 1 | 0.746 |
MAPKAPK3 |
0.849 | 0.031 | -3 | 0.783 |
TSSK2 |
0.849 | -0.006 | -5 | 0.854 |
HUNK |
0.849 | -0.136 | 2 | 0.782 |
GRK4 |
0.849 | -0.045 | -2 | 0.852 |
ANKRD3 |
0.849 | -0.202 | 1 | 0.789 |
YSK4 |
0.849 | -0.097 | 1 | 0.721 |
LATS2 |
0.849 | 0.020 | -5 | 0.752 |
MLK3 |
0.849 | -0.018 | 2 | 0.724 |
PKACG |
0.849 | 0.064 | -2 | 0.773 |
ERK2 |
0.849 | 0.202 | 1 | 0.782 |
ATM |
0.848 | -0.029 | 1 | 0.703 |
NEK9 |
0.848 | -0.179 | 2 | 0.803 |
CDK14 |
0.848 | 0.253 | 1 | 0.767 |
GSK3A |
0.847 | 0.160 | 4 | 0.489 |
JNK1 |
0.847 | 0.247 | 1 | 0.744 |
CDK16 |
0.847 | 0.269 | 1 | 0.710 |
MPSK1 |
0.846 | 0.145 | 1 | 0.744 |
PAK1 |
0.846 | 0.049 | -2 | 0.827 |
TSSK1 |
0.846 | 0.012 | -3 | 0.882 |
DYRK3 |
0.846 | 0.241 | 1 | 0.797 |
PKACB |
0.846 | 0.150 | -2 | 0.711 |
GAK |
0.846 | 0.104 | 1 | 0.820 |
MSK1 |
0.846 | 0.116 | -3 | 0.765 |
AMPKA2 |
0.846 | 0.011 | -3 | 0.832 |
CDK10 |
0.845 | 0.266 | 1 | 0.757 |
PLK1 |
0.845 | -0.084 | -2 | 0.796 |
DNAPK |
0.845 | 0.026 | 1 | 0.648 |
PKCA |
0.844 | 0.043 | 2 | 0.703 |
CDK2 |
0.844 | 0.133 | 1 | 0.812 |
CDK9 |
0.844 | 0.194 | 1 | 0.775 |
MST3 |
0.844 | 0.027 | 2 | 0.817 |
BCKDK |
0.844 | -0.152 | -1 | 0.778 |
GRK2 |
0.844 | 0.012 | -2 | 0.748 |
AKT2 |
0.843 | 0.106 | -3 | 0.711 |
MSK2 |
0.843 | 0.050 | -3 | 0.766 |
RIPK1 |
0.843 | -0.220 | 1 | 0.736 |
PIM2 |
0.842 | 0.087 | -3 | 0.760 |
BRAF |
0.842 | -0.098 | -4 | 0.863 |
TAO3 |
0.842 | -0.004 | 1 | 0.746 |
PKCB |
0.842 | 0.017 | 2 | 0.714 |
MYLK4 |
0.842 | 0.056 | -2 | 0.812 |
TLK2 |
0.841 | -0.085 | 1 | 0.700 |
SGK3 |
0.841 | 0.075 | -3 | 0.775 |
AURA |
0.840 | 0.100 | -2 | 0.683 |
AURB |
0.840 | 0.082 | -2 | 0.700 |
PKCG |
0.840 | 0.005 | 2 | 0.714 |
QSK |
0.840 | 0.027 | 4 | 0.803 |
NIM1 |
0.840 | -0.075 | 3 | 0.740 |
TTBK2 |
0.840 | -0.182 | 2 | 0.671 |
ULK1 |
0.840 | -0.236 | -3 | 0.819 |
PAK3 |
0.839 | -0.013 | -2 | 0.817 |
PRKD3 |
0.839 | 0.033 | -3 | 0.757 |
PRKX |
0.839 | 0.163 | -3 | 0.710 |
CK2A2 |
0.839 | 0.171 | 1 | 0.733 |
MEKK2 |
0.839 | -0.116 | 2 | 0.773 |
MLK4 |
0.839 | -0.098 | 2 | 0.690 |
GCK |
0.839 | 0.039 | 1 | 0.748 |
WNK3 |
0.839 | -0.308 | 1 | 0.739 |
MEK5 |
0.838 | -0.256 | 2 | 0.795 |
MEKK3 |
0.838 | -0.147 | 1 | 0.747 |
NEK5 |
0.838 | -0.125 | 1 | 0.750 |
DRAK1 |
0.838 | -0.039 | 1 | 0.748 |
SMG1 |
0.838 | -0.068 | 1 | 0.709 |
MNK2 |
0.838 | 0.031 | -2 | 0.823 |
GSK3B |
0.837 | 0.063 | 4 | 0.480 |
MOK |
0.837 | 0.247 | 1 | 0.808 |
DCAMKL1 |
0.837 | -0.000 | -3 | 0.801 |
PLK3 |
0.837 | -0.090 | 2 | 0.764 |
CAMK4 |
0.837 | -0.102 | -3 | 0.825 |
IRE1 |
0.837 | -0.148 | 1 | 0.712 |
NEK2 |
0.836 | -0.153 | 2 | 0.779 |
CK1E |
0.836 | 0.102 | -3 | 0.636 |
PKG2 |
0.836 | 0.071 | -2 | 0.708 |
PKCZ |
0.836 | -0.053 | 2 | 0.744 |
ERK7 |
0.835 | 0.072 | 2 | 0.512 |
MEKK1 |
0.835 | -0.200 | 1 | 0.736 |
ZAK |
0.835 | -0.179 | 1 | 0.725 |
CHK1 |
0.835 | -0.062 | -3 | 0.820 |
MARK3 |
0.835 | 0.020 | 4 | 0.763 |
PAK2 |
0.834 | -0.032 | -2 | 0.809 |
DAPK3 |
0.834 | 0.073 | -3 | 0.819 |
MNK1 |
0.834 | 0.016 | -2 | 0.828 |
MELK |
0.834 | -0.072 | -3 | 0.809 |
PKCH |
0.834 | -0.049 | 2 | 0.692 |
LKB1 |
0.834 | -0.048 | -3 | 0.840 |
CK1D |
0.834 | 0.107 | -3 | 0.587 |
PERK |
0.833 | -0.189 | -2 | 0.838 |
SMMLCK |
0.833 | -0.010 | -3 | 0.826 |
TNIK |
0.833 | 0.021 | 3 | 0.835 |
MARK2 |
0.833 | -0.016 | 4 | 0.732 |
QIK |
0.833 | -0.120 | -3 | 0.833 |
CDK6 |
0.832 | 0.207 | 1 | 0.750 |
CHAK1 |
0.831 | -0.208 | 2 | 0.740 |
BRSK1 |
0.831 | -0.013 | -3 | 0.802 |
SIK |
0.831 | -0.006 | -3 | 0.771 |
HPK1 |
0.831 | 0.005 | 1 | 0.736 |
TAK1 |
0.831 | -0.070 | 1 | 0.750 |
NEK11 |
0.831 | -0.170 | 1 | 0.742 |
EEF2K |
0.831 | -0.038 | 3 | 0.798 |
TAO2 |
0.830 | -0.116 | 2 | 0.823 |
PDK1 |
0.830 | -0.080 | 1 | 0.745 |
IRE2 |
0.830 | -0.150 | 2 | 0.705 |
MST2 |
0.830 | -0.089 | 1 | 0.749 |
GRK3 |
0.830 | 0.027 | -2 | 0.710 |
PAK6 |
0.830 | 0.077 | -2 | 0.741 |
CDK4 |
0.830 | 0.213 | 1 | 0.734 |
PHKG1 |
0.829 | -0.085 | -3 | 0.836 |
TLK1 |
0.829 | -0.152 | -2 | 0.843 |
PINK1 |
0.829 | -0.163 | 1 | 0.802 |
MINK |
0.829 | -0.057 | 1 | 0.725 |
CK2A1 |
0.829 | 0.145 | 1 | 0.713 |
CAMKK1 |
0.828 | -0.194 | -2 | 0.751 |
HRI |
0.828 | -0.264 | -2 | 0.852 |
NUAK1 |
0.828 | -0.077 | -3 | 0.800 |
DAPK1 |
0.828 | 0.071 | -3 | 0.805 |
CAMKK2 |
0.828 | -0.150 | -2 | 0.754 |
AKT1 |
0.828 | 0.079 | -3 | 0.727 |
PKACA |
0.828 | 0.106 | -2 | 0.662 |
KHS1 |
0.828 | 0.029 | 1 | 0.718 |
MAP3K15 |
0.828 | -0.089 | 1 | 0.714 |
WNK4 |
0.828 | -0.170 | -2 | 0.896 |
HGK |
0.828 | -0.062 | 3 | 0.829 |
CK1A2 |
0.827 | 0.084 | -3 | 0.587 |
KHS2 |
0.827 | 0.047 | 1 | 0.734 |
NEK8 |
0.827 | -0.216 | 2 | 0.782 |
CAMK1G |
0.826 | -0.048 | -3 | 0.773 |
MARK1 |
0.826 | -0.055 | 4 | 0.776 |
PDHK3_TYR |
0.825 | 0.367 | 4 | 0.886 |
LRRK2 |
0.825 | -0.164 | 2 | 0.814 |
PBK |
0.825 | 0.045 | 1 | 0.751 |
PLK4 |
0.825 | -0.155 | 2 | 0.587 |
MEKK6 |
0.825 | -0.129 | 1 | 0.739 |
DCAMKL2 |
0.824 | -0.076 | -3 | 0.815 |
ROCK2 |
0.824 | 0.075 | -3 | 0.802 |
SGK1 |
0.823 | 0.100 | -3 | 0.634 |
BRSK2 |
0.823 | -0.099 | -3 | 0.814 |
VRK1 |
0.823 | -0.162 | 2 | 0.799 |
IRAK4 |
0.823 | -0.201 | 1 | 0.712 |
SSTK |
0.823 | -0.038 | 4 | 0.782 |
NEK1 |
0.822 | -0.145 | 1 | 0.722 |
NEK4 |
0.821 | -0.202 | 1 | 0.711 |
PKCT |
0.821 | -0.046 | 2 | 0.699 |
PKCE |
0.821 | 0.023 | 2 | 0.699 |
CAMK1D |
0.820 | 0.000 | -3 | 0.694 |
MAPKAPK5 |
0.820 | -0.108 | -3 | 0.726 |
MST1 |
0.820 | -0.149 | 1 | 0.725 |
BUB1 |
0.819 | 0.081 | -5 | 0.789 |
DMPK1 |
0.819 | 0.096 | -3 | 0.773 |
P70S6K |
0.819 | -0.009 | -3 | 0.716 |
PLK2 |
0.818 | -0.040 | -3 | 0.780 |
MRCKB |
0.818 | 0.055 | -3 | 0.748 |
AKT3 |
0.818 | 0.096 | -3 | 0.653 |
LOK |
0.817 | -0.113 | -2 | 0.773 |
PKCI |
0.817 | -0.059 | 2 | 0.710 |
SNRK |
0.816 | -0.239 | 2 | 0.638 |
PDHK4_TYR |
0.816 | 0.179 | 2 | 0.869 |
MRCKA |
0.816 | 0.030 | -3 | 0.763 |
OSR1 |
0.815 | -0.067 | 2 | 0.767 |
MAP2K4_TYR |
0.815 | 0.148 | -1 | 0.866 |
SBK |
0.815 | 0.084 | -3 | 0.588 |
CK1G1 |
0.815 | 0.025 | -3 | 0.634 |
MAP2K6_TYR |
0.815 | 0.153 | -1 | 0.867 |
YSK1 |
0.814 | -0.129 | 2 | 0.779 |
SLK |
0.813 | -0.132 | -2 | 0.720 |
TESK1_TYR |
0.812 | 0.035 | 3 | 0.853 |
BMPR2_TYR |
0.812 | 0.119 | -1 | 0.878 |
PDHK1_TYR |
0.811 | 0.111 | -1 | 0.886 |
TTK |
0.811 | -0.090 | -2 | 0.826 |
MEK2 |
0.811 | -0.306 | 2 | 0.778 |
CHK2 |
0.811 | -0.008 | -3 | 0.650 |
BIKE |
0.811 | 0.031 | 1 | 0.721 |
PAK5 |
0.810 | 0.015 | -2 | 0.682 |
PKMYT1_TYR |
0.809 | 0.027 | 3 | 0.815 |
TTBK1 |
0.808 | -0.238 | 2 | 0.593 |
ASK1 |
0.808 | -0.155 | 1 | 0.706 |
ALPHAK3 |
0.807 | -0.050 | -1 | 0.760 |
PHKG2 |
0.807 | -0.118 | -3 | 0.800 |
HASPIN |
0.807 | -0.020 | -1 | 0.664 |
CRIK |
0.807 | 0.063 | -3 | 0.725 |
IRAK1 |
0.806 | -0.383 | -1 | 0.717 |
EPHA6 |
0.806 | 0.105 | -1 | 0.867 |
MAP2K7_TYR |
0.806 | -0.125 | 2 | 0.842 |
MYO3B |
0.806 | -0.081 | 2 | 0.795 |
PAK4 |
0.806 | 0.032 | -2 | 0.694 |
ROCK1 |
0.806 | 0.034 | -3 | 0.762 |
PKN1 |
0.805 | -0.039 | -3 | 0.730 |
LIMK2_TYR |
0.805 | 0.042 | -3 | 0.885 |
CAMK1A |
0.805 | -0.006 | -3 | 0.668 |
TXK |
0.803 | 0.152 | 1 | 0.818 |
EPHB4 |
0.803 | 0.068 | -1 | 0.839 |
STK33 |
0.801 | -0.221 | 2 | 0.588 |
MYO3A |
0.801 | -0.133 | 1 | 0.703 |
PINK1_TYR |
0.800 | -0.192 | 1 | 0.795 |
NEK3 |
0.799 | -0.238 | 1 | 0.692 |
AAK1 |
0.799 | 0.086 | 1 | 0.638 |
YANK3 |
0.799 | -0.057 | 2 | 0.392 |
ABL2 |
0.798 | 0.038 | -1 | 0.796 |
RET |
0.797 | -0.129 | 1 | 0.743 |
TAO1 |
0.797 | -0.159 | 1 | 0.664 |
FGR |
0.796 | -0.014 | 1 | 0.807 |
RIPK2 |
0.796 | -0.369 | 1 | 0.679 |
EPHA4 |
0.794 | 0.024 | 2 | 0.773 |
LCK |
0.794 | 0.074 | -1 | 0.842 |
YES1 |
0.794 | -0.025 | -1 | 0.841 |
LIMK1_TYR |
0.794 | -0.192 | 2 | 0.826 |
BLK |
0.793 | 0.096 | -1 | 0.849 |
ABL1 |
0.793 | 0.011 | -1 | 0.788 |
MST1R |
0.792 | -0.165 | 3 | 0.754 |
TYRO3 |
0.791 | -0.158 | 3 | 0.743 |
CSF1R |
0.791 | -0.116 | 3 | 0.729 |
ROS1 |
0.791 | -0.149 | 3 | 0.707 |
HCK |
0.790 | -0.025 | -1 | 0.835 |
SRMS |
0.790 | -0.017 | 1 | 0.814 |
JAK3 |
0.790 | -0.107 | 1 | 0.734 |
FER |
0.790 | -0.107 | 1 | 0.830 |
STLK3 |
0.790 | -0.263 | 1 | 0.681 |
JAK2 |
0.789 | -0.180 | 1 | 0.741 |
EPHB2 |
0.789 | 0.008 | -1 | 0.826 |
ITK |
0.789 | -0.021 | -1 | 0.791 |
FYN |
0.789 | 0.081 | -1 | 0.829 |
DDR1 |
0.788 | -0.189 | 4 | 0.787 |
INSRR |
0.788 | -0.102 | 3 | 0.680 |
TYK2 |
0.788 | -0.273 | 1 | 0.736 |
EPHB3 |
0.788 | -0.027 | -1 | 0.824 |
TNK2 |
0.788 | -0.052 | 3 | 0.699 |
EPHB1 |
0.787 | -0.054 | 1 | 0.808 |
CK1A |
0.786 | 0.056 | -3 | 0.504 |
PKG1 |
0.786 | -0.012 | -2 | 0.620 |
BMX |
0.784 | -0.019 | -1 | 0.723 |
FGFR2 |
0.783 | -0.158 | 3 | 0.735 |
MERTK |
0.783 | -0.069 | 3 | 0.715 |
KIT |
0.783 | -0.147 | 3 | 0.731 |
MET |
0.781 | -0.093 | 3 | 0.726 |
KDR |
0.781 | -0.141 | 3 | 0.686 |
NEK10_TYR |
0.780 | -0.149 | 1 | 0.634 |
EPHA7 |
0.780 | -0.037 | 2 | 0.762 |
TNNI3K_TYR |
0.780 | -0.081 | 1 | 0.746 |
JAK1 |
0.779 | -0.115 | 1 | 0.688 |
FLT1 |
0.779 | -0.092 | -1 | 0.836 |
PTK2 |
0.779 | 0.083 | -1 | 0.817 |
TEC |
0.778 | -0.098 | -1 | 0.727 |
FLT3 |
0.777 | -0.229 | 3 | 0.739 |
EPHA3 |
0.777 | -0.112 | 2 | 0.738 |
SYK |
0.777 | 0.085 | -1 | 0.802 |
TNK1 |
0.776 | -0.160 | 3 | 0.730 |
PDGFRB |
0.776 | -0.271 | 3 | 0.742 |
TEK |
0.776 | -0.201 | 3 | 0.668 |
FGFR1 |
0.776 | -0.217 | 3 | 0.700 |
AXL |
0.776 | -0.187 | 3 | 0.710 |
PTK2B |
0.775 | -0.032 | -1 | 0.763 |
EPHA5 |
0.774 | -0.039 | 2 | 0.756 |
LYN |
0.774 | -0.082 | 3 | 0.654 |
FGFR3 |
0.774 | -0.160 | 3 | 0.701 |
BTK |
0.773 | -0.218 | -1 | 0.750 |
WEE1_TYR |
0.773 | -0.154 | -1 | 0.724 |
FRK |
0.773 | -0.104 | -1 | 0.847 |
SRC |
0.772 | -0.049 | -1 | 0.818 |
ERBB2 |
0.772 | -0.193 | 1 | 0.717 |
EPHA1 |
0.772 | -0.130 | 3 | 0.698 |
EPHA8 |
0.771 | -0.062 | -1 | 0.817 |
LTK |
0.771 | -0.187 | 3 | 0.670 |
EGFR |
0.771 | -0.082 | 1 | 0.634 |
DDR2 |
0.770 | -0.069 | 3 | 0.660 |
NTRK1 |
0.770 | -0.257 | -1 | 0.802 |
ALK |
0.770 | -0.223 | 3 | 0.645 |
CK1G3 |
0.770 | 0.008 | -3 | 0.460 |
INSR |
0.768 | -0.205 | 3 | 0.660 |
PTK6 |
0.768 | -0.276 | -1 | 0.704 |
NTRK3 |
0.767 | -0.182 | -1 | 0.759 |
MATK |
0.767 | -0.150 | -1 | 0.723 |
YANK2 |
0.766 | -0.094 | 2 | 0.411 |
PDGFRA |
0.766 | -0.356 | 3 | 0.739 |
FGFR4 |
0.764 | -0.124 | -1 | 0.765 |
FLT4 |
0.764 | -0.268 | 3 | 0.683 |
CSK |
0.764 | -0.173 | 2 | 0.762 |
NTRK2 |
0.763 | -0.309 | 3 | 0.683 |
EPHA2 |
0.762 | -0.065 | -1 | 0.788 |
ERBB4 |
0.760 | -0.047 | 1 | 0.660 |
ZAP70 |
0.755 | -0.000 | -1 | 0.711 |
CK1G2 |
0.754 | 0.002 | -3 | 0.552 |
IGF1R |
0.754 | -0.188 | 3 | 0.598 |
MUSK |
0.748 | -0.224 | 1 | 0.623 |
FES |
0.741 | -0.179 | -1 | 0.696 |