Motif 1195 (n=122)

Position-wise Probabilities
Download
uniprot genes site source protein function
A0A087WTJ2 GIMAP1-GIMAP5 Y14 ochoa GIMAP1-GIMAP5 readthrough None
A1L4K1 FSD2 T15 ochoa Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1) None
A2RRP1 NBAS T14 ochoa NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}.
O00767 SCD Y14 psp Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). {ECO:0000250|UniProtKB:P13516, ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:18765284}.
O43482 OIP5 T14 ochoa Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.
O43768 ENSA T14 ochoa Alpha-endosulfine (ARPP-19e) Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}.
O60306 AQR T14 ochoa RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
O60503 ADCY9 T15 ochoa Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.
O60664 PLIN3 T15 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O60711 LPXN T15 ochoa Leupaxin Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
O75582 RPS6KA5 T14 ochoa Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
O75694 NUP155 T14 ochoa Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
O76021 RSL1D1 T15 ochoa Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.
O94804 STK10 T14 ochoa Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
P01583 IL1A Y15 ochoa Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1) Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed:17507369, PubMed:2950091). Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 (PubMed:17507369). In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways (PubMed:14687581). Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage (PubMed:15679580). In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity (PubMed:26439902). {ECO:0000269|PubMed:14687581, ECO:0000269|PubMed:15679580, ECO:0000269|PubMed:17507369, ECO:0000269|PubMed:26439902, ECO:0000269|PubMed:2950091, ECO:0000269|PubMed:3258335}.
P06241 FYN T15 ochoa Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}.
P06454 PTMA T14 ochoa Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
P06493 CDK1 T14 ochoa|psp Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}.
P06493 CDK1 Y15 ochoa|psp Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}.
P08473 MME T15 psp Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991, PubMed:6349683). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675, PubMed:6349683). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:16254193, PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:2972276, ECO:0000269|PubMed:6208535, ECO:0000269|PubMed:6349683}.
P09234 SNRPC T14 ochoa U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.
P0CG47 UBB T14 ochoa Polyubiquitin-B [Cleaved into: Ubiquitin] [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.
P0CG48 UBC T14 ochoa Polyubiquitin-C [Cleaved into: Ubiquitin] [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}.
P10244 MYBL2 Y15 psp Myb-related protein B (B-Myb) (Myb-like protein 2) Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.
P11142 HSPA8 T14 ochoa Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.
P11142 HSPA8 Y15 ochoa Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.
P12883 MYH7 Y15 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P14923 JUP T14 ochoa Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.
P15259 PGAM2 T15 ochoa Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M) Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
P22460 KCNA5 T15 psp Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets. {ECO:0000250|UniProtKB:Q61762, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:17267549, ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:36917789, ECO:0000269|PubMed:8505626}.; FUNCTION: [Isoform 2]: Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation. {ECO:0000269|PubMed:11524461}.
P23588 EIF4B T14 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P24941 CDK2 T14 ochoa|psp Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}.
P24941 CDK2 Y15 ochoa|psp Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}.
P25788 PSMA3 T14 ochoa Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}.
P28066 PSMA5 T14 ochoa Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P35659 DEK T15 ochoa|psp Protein DEK Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.
P37268 FDFT1 Y14 ochoa Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1) Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. {ECO:0000269|PubMed:10896663, ECO:0000269|PubMed:24531458}.
P39687 ANP32A T15 ochoa Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.
P41226 UBA7 Y15 ochoa Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog) E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865). {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:19073728, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27545325, ECO:0000269|PubMed:27564865, ECO:0000269|PubMed:29056542, ECO:0000269|PubMed:29743376, ECO:0000269|PubMed:37722521}.
P43487 RANBP1 T15 ochoa Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}.
P46782 RPS5 T14 ochoa Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P49207 RPL34 T15 ochoa Large ribosomal subunit protein eL34 (60S ribosomal protein L34) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
P49279 SLC11A1 Y15 psp Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1) Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable). {ECO:0000269|PubMed:11237855, ECO:0000305|PubMed:16103355, ECO:0000305|PubMed:16395392}.
P49757 NUMB Y15 ochoa Protein numb homolog (h-Numb) (Protein S171) Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
P50402 EMD T14 ochoa Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P50851 LRBA T14 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P52298 NCBP2 Y14 ochoa Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17363367, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:26382858}.
P55072 VCP T14 ochoa Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.
P61978 HNRNPK T15 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P62979 RPS27A T14 ochoa Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}.
P62987 UBA52 T14 ochoa Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}.
P78563 ADARB1 T14 ochoa Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.
Q00526 CDK3 T14 ochoa|psp Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}.
Q00526 CDK3 Y15 ochoa|psp Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}.
Q00535 CDK5 T14 ochoa Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.
Q00535 CDK5 Y15 ochoa|psp Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.
Q01130 SRSF2 T14 ochoa Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Q03135 CAV1 Y14 ochoa|psp Caveolin-1 May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.
Q03135 CAV1 T15 ochoa Caveolin-1 May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.
Q13277 STX3 T14 psp Syntaxin-3 Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}.
Q13322 GRB10 Y15 ochoa Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.
Q13451 FKBP5 T15 ochoa Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}.
Q13576 IQGAP2 Y14 psp Ras GTPase-activating-like protein IQGAP2 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Q15019 SEPTIN2 T14 ochoa Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}.
Q15233 NONO T15 ochoa Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}.
Q16254 E2F4 T14 ochoa Transcription factor E2F4 (E2F-4) Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
Q5UIP0 RIF1 T15 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q68CQ4 UTP25 T15 ochoa U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}.
Q7Z3C6 ATG9A Y15 ochoa|psp Autophagy-related protein 9A (APG9-like 1) (mATG9) Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}.
Q86TU7 SETD3 T14 ochoa Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.
Q86YV0 RASAL3 T15 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q8IWA5 SLC44A2 T14 ochoa Choline transporter-like protein 2 (Solute carrier family 44 member 2) [Isoform 1]: Choline/H+ antiporter, mainly in mitochodria (PubMed:10677542, PubMed:20665236, PubMed:23651124, PubMed:33789160). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:33789160}.; FUNCTION: [Isoform 3]: Does not exhibit choline transporter activity. {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236}.
Q8IWJ2 GCC2 T14 ochoa GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.
Q8IY95 TMEM192 T15 ochoa Transmembrane protein 192 None
Q8IZV2 CMTM8 T14 ochoa CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8) None
Q8N4S9 MARVELD2 Y14 ochoa MARVEL domain-containing protein 2 (Tricellulin) Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}.
Q8NAV1 PRPF38A T15 ochoa Pre-mRNA-splicing factor 38A Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:26673105, ECO:0000269|PubMed:28781166}.
Q8NHG8 ZNRF2 T15 ochoa E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}.
Q8WTQ4 C16orf78 T14 ochoa Uncharacterized protein C16orf78 None
Q8WWP7 GIMAP1 Y14 ochoa GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1) May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). {ECO:0000250}.
Q8WXS3 BAALC Y15 ochoa Brain and acute leukemia cytoplasmic protein May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}.
Q92688 ANP32B T15 ochoa Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.
Q92997 DVL3 T15 ochoa|psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q969T4 UBE2E3 T15 ochoa Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}.
Q96BX8 MOB3A T15 psp MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) May regulate the activity of kinases. {ECO:0000250}.
Q96FC7 PHYHIPL T14 ochoa Phytanoyl-CoA hydroxylase-interacting protein-like May play a role in the development of the central system. {ECO:0000250}.
Q96LR5 UBE2E2 T14 ochoa Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:9371400}.
Q96LT9 RNPC3 T15 ochoa RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269|PubMed:16096647, ECO:0000269|PubMed:19447915, ECO:0000269|PubMed:24480542, ECO:0000269|PubMed:29255062}.
Q96QD9 FYTTD1 T14 ochoa UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}.
Q96S97 MYADM T14 ochoa Myeloid-associated differentiation marker (Protein SB135) None
Q96S97 MYADM T15 ochoa Myeloid-associated differentiation marker (Protein SB135) None
Q99962 SH3GL2 T14 psp Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}.
Q9H0H3 KLHL25 T15 ochoa Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}.
Q9H0U9 TSPYL1 T15 ochoa Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) None
Q9H6S3 EPS8L2 T14 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9H8V3 ECT2 T14 ochoa Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}.
Q9NQC7 CYLD Y15 ochoa|psp Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}.
Q9NR30 DDX21 T15 ochoa Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.
Q9UHR5 SAP30BP Y14 ochoa SAP30-binding protein (Transcriptional regulator protein HCNGP) Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}.
Q9ULM3 YEATS2 Y15 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9UPY5 SLC7A11 Y15 ochoa Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15151999, PubMed:34880232, PubMed:35245456, PubMed:35352032). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:11133847, PubMed:11417227). In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (PubMed:35245456). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (PubMed:34120018). In vitro can also transport L-aspartate (PubMed:11417227). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity). {ECO:0000250|UniProtKB:Q9WTR6, ECO:0000269|PubMed:11133847, ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:14722095, ECO:0000269|PubMed:15151999, ECO:0000269|PubMed:34120018, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35245456, ECO:0000269|PubMed:35352032}.
Q9UPZ9 CILK1 Y15 psp Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}.
Q9Y314 NOSIP Y14 ochoa Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.
Q9Y3L3 SH3BP1 T15 ochoa SH3 domain-binding protein 1 GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
Q9Y5S1 TRPV2 T14 ochoa Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}.
P62280 RPS11 T15 Sugiyama Small ribosomal subunit protein uS17 (40S ribosomal protein S11) Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P63173 RPL38 T14 Sugiyama Large ribosomal subunit protein eL38 (60S ribosomal protein L38) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
Q15427 SF3B4 T14 Sugiyama Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}.
P61513 RPL37A Y14 Sugiyama Large ribosomal subunit protein eL43 (60S ribosomal protein L37a) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P62942 FKBP1A T15 Sugiyama Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}.
P18077 RPL35A Y14 Sugiyama Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein) Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferation and viability of hematopoietic cells (PubMed:18535205). {ECO:0000269|PubMed:18535205, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P50914 RPL14 Y14 Sugiyama Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
Q13557 CAMK2D Y14 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
Q8IXH7 NELFCD Y14 SIGNOR Negative elongation factor C/D (NELF-C/D) (TH1-like protein) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
Q96B26 EXOSC8 Y14 Sugiyama Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}.
P55036 PSMD4 Y15 Sugiyama 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}.
P55010 EIF5 Y14 Sugiyama Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
Q9NPI1 BRD7 Y15 Sugiyama Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.
P61158 ACTR3 T14 Sugiyama Actin-related protein 3 (Actin-like protein 3) ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.
Q9HCX4 TRPC7 T15 SIGNOR Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250|UniProtKB:Q9WVC5}.
P61160 ACTR2 T15 Sugiyama Actin-related protein 2 (Actin-like protein 2) ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.
Q8NG66 NEK11 T15 Sugiyama Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.
Download
reactome_id name p -log10_p
R-HSA-9948299 Ribosome-associated quality control 3.552714e-15 14.449
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 1.665335e-14 13.778
R-HSA-422475 Axon guidance 1.276756e-14 13.894
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 4.163336e-14 13.381
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 4.762857e-14 13.322
R-HSA-8953854 Metabolism of RNA 6.838974e-14 13.165
R-HSA-9675108 Nervous system development 6.195044e-14 13.208
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.766676e-13 12.558
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 4.535261e-13 12.343
R-HSA-72613 Eukaryotic Translation Initiation 8.545387e-13 12.068
R-HSA-72737 Cap-dependent Translation Initiation 8.545387e-13 12.068
R-HSA-376176 Signaling by ROBO receptors 1.390998e-12 11.857
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.408029e-12 11.356
R-HSA-156902 Peptide chain elongation 4.845346e-12 11.315
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 7.042700e-12 11.152
R-HSA-927802 Nonsense-Mediated Decay (NMD) 6.774692e-12 11.169
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6.774692e-12 11.169
R-HSA-156842 Eukaryotic Translation Elongation 8.977707e-12 11.047
R-HSA-72689 Formation of a pool of free 40S subunits 1.437450e-11 10.842
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.402212e-11 10.853
R-HSA-72764 Eukaryotic Translation Termination 1.437450e-11 10.842
R-HSA-2408557 Selenocysteine synthesis 2.814038e-11 10.551
R-HSA-192823 Viral mRNA Translation 3.490486e-11 10.457
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 3.881562e-11 10.411
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.271594e-11 10.278
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.878908e-11 10.231
R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.008208e-10 9.300
R-HSA-72312 rRNA processing 8.834465e-10 9.054
R-HSA-2262752 Cellular responses to stress 1.297060e-09 8.887
R-HSA-8953897 Cellular responses to stimuli 1.267113e-09 8.897
R-HSA-72766 Translation 2.777652e-09 8.556
R-HSA-168255 Influenza Infection 2.758841e-09 8.559
R-HSA-9711097 Cellular response to starvation 6.267531e-09 8.203
R-HSA-2408522 Selenoamino acid metabolism 9.272985e-09 8.033
R-HSA-453279 Mitotic G1 phase and G1/S transition 2.721289e-08 7.565
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 4.496322e-08 7.347
R-HSA-9766229 Degradation of CDH1 4.859765e-08 7.313
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 5.743566e-08 7.241
R-HSA-9613829 Chaperone Mediated Autophagy 6.761471e-08 7.170
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 1.305803e-07 6.884
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.274796e-07 6.895
R-HSA-9764561 Regulation of CDH1 Function 1.311198e-07 6.882
R-HSA-5689877 Josephin domain DUBs 1.305803e-07 6.884
R-HSA-4641258 Degradation of DVL 1.486621e-07 6.828
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.287524e-07 6.641
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 2.633671e-07 6.579
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 2.633671e-07 6.579
R-HSA-69615 G1/S DNA Damage Checkpoints 2.543856e-07 6.595
R-HSA-5362768 Hh mutants are degraded by ERAD 2.655844e-07 6.576
R-HSA-5610780 Degradation of GLI1 by the proteasome 3.046194e-07 6.516
R-HSA-5387390 Hh mutants abrogate ligand secretion 3.973004e-07 6.401
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 4.518798e-07 6.345
R-HSA-9706377 FLT3 signaling by CBL mutants 5.221228e-07 6.282
R-HSA-69202 Cyclin E associated events during G1/S transition 5.129767e-07 6.290
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.126283e-07 6.290
R-HSA-69206 G1/S Transition 5.068583e-07 6.295
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5.126283e-07 6.290
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 5.126283e-07 6.290
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 5.493710e-07 6.260
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.639013e-07 6.249
R-HSA-453276 Regulation of mitotic cell cycle 5.639013e-07 6.249
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.190875e-07 6.208
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 6.417824e-07 6.193
R-HSA-9615710 Late endosomal microautophagy 7.709314e-07 6.113
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 8.351560e-07 6.078
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 8.351560e-07 6.078
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 8.351560e-07 6.078
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 8.351560e-07 6.078
R-HSA-69563 p53-Dependent G1 DNA Damage Response 8.288682e-07 6.082
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 8.288682e-07 6.082
R-HSA-9694493 Maturation of protein E 8.847309e-07 6.053
R-HSA-9683683 Maturation of protein E 8.847309e-07 6.053
R-HSA-5658442 Regulation of RAS by GAPs 9.294595e-07 6.032
R-HSA-5358346 Hedgehog ligand biogenesis 1.040092e-06 5.983
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 1.060827e-06 5.974
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 1.060827e-06 5.974
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 1.071826e-06 5.970
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.161556e-06 5.935
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 1.161556e-06 5.935
R-HSA-68949 Orc1 removal from chromatin 1.161556e-06 5.935
R-HSA-9692914 SARS-CoV-1-host interactions 1.125709e-06 5.949
R-HSA-1538133 G0 and Early G1 1.236088e-06 5.908
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.294684e-06 5.888
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1.358457e-06 5.867
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 1.440359e-06 5.842
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.599510e-06 5.796
R-HSA-180534 Vpu mediated degradation of CD4 1.657816e-06 5.780
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.773116e-06 5.751
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 1.908949e-06 5.719
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.908949e-06 5.719
R-HSA-8948747 Regulation of PTEN localization 2.131056e-06 5.671
R-HSA-9824446 Viral Infection Pathways 2.011331e-06 5.697
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 2.190292e-06 5.659
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 2.190292e-06 5.659
R-HSA-169911 Regulation of Apoptosis 2.190292e-06 5.659
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 2.593786e-06 5.586
R-HSA-937041 IKK complex recruitment mediated by RIP1 2.593786e-06 5.586
R-HSA-110320 Translesion Synthesis by POLH 2.593786e-06 5.586
R-HSA-180585 Vif-mediated degradation of APOBEC3G 2.504566e-06 5.601
R-HSA-912631 Regulation of signaling by CBL 2.593786e-06 5.586
R-HSA-9663891 Selective autophagy 2.556265e-06 5.592
R-HSA-6804757 Regulation of TP53 Degradation 2.504566e-06 5.601
R-HSA-5689896 Ovarian tumor domain proteases 2.854654e-06 5.544
R-HSA-4641257 Degradation of AXIN 2.854654e-06 5.544
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 2.854654e-06 5.544
R-HSA-3785653 Myoclonic epilepsy of Lafora 3.099121e-06 5.509
R-HSA-1253288 Downregulation of ERBB4 signaling 3.099121e-06 5.509
R-HSA-9637628 Modulation by Mtb of host immune system 3.099121e-06 5.509
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 3.099121e-06 5.509
R-HSA-6807004 Negative regulation of MET activity 3.159040e-06 5.500
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.179908e-06 5.498
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 3.674657e-06 5.435
R-HSA-69541 Stabilization of p53 3.674657e-06 5.435
R-HSA-6806003 Regulation of TP53 Expression and Degradation 3.674657e-06 5.435
R-HSA-162909 Host Interactions of HIV factors 3.981087e-06 5.400
R-HSA-8941858 Regulation of RUNX3 expression and activity 4.151200e-06 5.382
R-HSA-9604323 Negative regulation of NOTCH4 signaling 4.151200e-06 5.382
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 4.359797e-06 5.361
R-HSA-8876384 Listeria monocytogenes entry into host cells 4.577512e-06 5.339
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 4.676824e-06 5.330
R-HSA-9932298 Degradation of CRY and PER proteins 5.255299e-06 5.279
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 5.255299e-06 5.279
R-HSA-5610783 Degradation of GLI2 by the proteasome 5.255299e-06 5.279
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 4.676824e-06 5.330
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 4.676824e-06 5.330
R-HSA-9607240 FLT3 Signaling 4.676824e-06 5.330
R-HSA-9664873 Pexophagy 5.964704e-06 5.224
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 6.403308e-06 5.194
R-HSA-5610787 Hedgehog 'off' state 6.790596e-06 5.168
R-HSA-5632684 Hedgehog 'on' state 6.950396e-06 5.158
R-HSA-69231 Cyclin D associated events in G1 7.348438e-06 5.134
R-HSA-69236 G1 Phase 7.348438e-06 5.134
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 7.968977e-06 5.099
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 7.968977e-06 5.099
R-HSA-69052 Switching of origins to a post-replicative state 8.161525e-06 5.088
R-HSA-4608870 Asymmetric localization of PCP proteins 8.179917e-06 5.087
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 8.179917e-06 5.087
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 9.086052e-06 5.042
R-HSA-8852135 Protein ubiquitination 9.542892e-06 5.020
R-HSA-5358351 Signaling by Hedgehog 1.000504e-05 5.000
R-HSA-5663205 Infectious disease 9.006147e-06 5.045
R-HSA-9678108 SARS-CoV-1 Infection 8.908968e-06 5.050
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.007182e-05 4.997
R-HSA-1266738 Developmental Biology 1.010029e-05 4.996
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 1.033851e-05 4.986
R-HSA-209560 NF-kB is activated and signals survival 1.043112e-05 4.982
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 1.197453e-05 4.922
R-HSA-4086400 PCP/CE pathway 1.197457e-05 4.922
R-HSA-5619084 ABC transporter disorders 1.197457e-05 4.922
R-HSA-162906 HIV Infection 1.222102e-05 4.913
R-HSA-73893 DNA Damage Bypass 1.230328e-05 4.910
R-HSA-5656169 Termination of translesion DNA synthesis 1.584864e-05 4.800
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 1.341289e-05 4.872
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 1.341289e-05 4.872
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 1.341289e-05 4.872
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 1.491849e-05 4.826
R-HSA-937039 IRAK1 recruits IKK complex 1.341289e-05 4.872
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.341289e-05 4.872
R-HSA-8866427 VLDLR internalisation and degradation 1.341289e-05 4.872
R-HSA-1169091 Activation of NF-kappaB in B cells 1.491849e-05 4.826
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 1.380590e-05 4.860
R-HSA-209543 p75NTR recruits signalling complexes 1.341289e-05 4.872
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 1.599515e-05 4.796
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 1.638480e-05 4.786
R-HSA-174490 Membrane binding and targetting of GAG proteins 1.697911e-05 4.770
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 1.796529e-05 4.746
R-HSA-8948751 Regulation of PTEN stability and activity 1.796529e-05 4.746
R-HSA-9755511 KEAP1-NFE2L2 pathway 1.967368e-05 4.706
R-HSA-5687128 MAPK6/MAPK4 signaling 1.969309e-05 4.706
R-HSA-182971 EGFR downregulation 2.063600e-05 4.685
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 2.107219e-05 4.676
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 2.119762e-05 4.674
R-HSA-205043 NRIF signals cell death from the nucleus 2.119762e-05 4.674
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2.119762e-05 4.674
R-HSA-72702 Ribosomal scanning and start codon recognition 2.345854e-05 4.630
R-HSA-5656121 Translesion synthesis by POLI 3.187679e-05 4.497
R-HSA-110312 Translesion synthesis by REV1 2.613905e-05 4.583
R-HSA-1295596 Spry regulation of FGF signaling 2.613905e-05 4.583
R-HSA-9758274 Regulation of NF-kappa B signaling 3.187679e-05 4.497
R-HSA-193639 p75NTR signals via NF-kB 2.613905e-05 4.583
R-HSA-9708530 Regulation of BACH1 activity 3.187679e-05 4.497
R-HSA-9706369 Negative regulation of FLT3 3.187679e-05 4.497
R-HSA-9759194 Nuclear events mediated by NFE2L2 2.731834e-05 4.564
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 3.353299e-05 4.475
R-HSA-168638 NOD1/2 Signaling Pathway 3.353299e-05 4.475
R-HSA-5205647 Mitophagy 3.353299e-05 4.475
R-HSA-8939902 Regulation of RUNX2 expression and activity 3.555763e-05 4.449
R-HSA-5655862 Translesion synthesis by POLK 3.848678e-05 4.415
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 3.848678e-05 4.415
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 3.848678e-05 4.415
R-HSA-69481 G2/M Checkpoints 3.891139e-05 4.410
R-HSA-4641263 Regulation of FZD by ubiquitination 4.604745e-05 4.337
R-HSA-3229121 Glycogen storage diseases 4.604745e-05 4.337
R-HSA-68882 Mitotic Anaphase 4.649912e-05 4.333
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 4.674912e-05 4.330
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.815391e-05 4.317
R-HSA-1234174 Cellular response to hypoxia 4.847024e-05 4.315
R-HSA-6804760 Regulation of TP53 Activity through Methylation 5.463959e-05 4.262
R-HSA-69278 Cell Cycle, Mitotic 5.690983e-05 4.245
R-HSA-382556 ABC-family proteins mediated transport 5.971661e-05 4.224
R-HSA-9020702 Interleukin-1 signaling 6.313151e-05 4.200
R-HSA-9646399 Aggrephagy 6.367381e-05 4.196
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 6.825556e-05 4.166
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.452062e-05 4.128
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 8.744548e-05 4.058
R-HSA-69275 G2/M Transition 8.606153e-05 4.065
R-HSA-1640170 Cell Cycle 6.787675e-05 4.168
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 8.744548e-05 4.058
R-HSA-1632852 Macroautophagy 8.142190e-05 4.089
R-HSA-9636383 Prevention of phagosomal-lysosomal fusion 8.744548e-05 4.058
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 8.744548e-05 4.058
R-HSA-9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 8.744548e-05 4.058
R-HSA-195253 Degradation of beta-catenin by the destruction complex 6.962067e-05 4.157
R-HSA-3322077 Glycogen synthesis 7.525245e-05 4.123
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 8.497428e-05 4.071
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 8.744548e-05 4.058
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 8.744548e-05 4.058
R-HSA-162599 Late Phase of HIV Life Cycle 8.874870e-05 4.052
R-HSA-9013694 Signaling by NOTCH4 9.136211e-05 4.039
R-HSA-69239 Synthesis of DNA 9.178169e-05 4.037
R-HSA-453274 Mitotic G2-G2/M phases 9.256258e-05 4.034
R-HSA-8856828 Clathrin-mediated endocytosis 9.261220e-05 4.033
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 9.317040e-05 4.031
R-HSA-2672351 Stimuli-sensing channels 9.662373e-05 4.015
R-HSA-1169408 ISG15 antiviral mechanism 9.756196e-05 4.011
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.010143e-04 3.996
R-HSA-175474 Assembly Of The HIV Virion 1.010143e-04 3.996
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 1.010143e-04 3.996
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 1.010143e-04 3.996
R-HSA-69002 DNA Replication Pre-Initiation 1.016718e-04 3.993
R-HSA-5689603 UCH proteinases 1.040919e-04 3.983
R-HSA-5684996 MAPK1/MAPK3 signaling 1.107069e-04 3.956
R-HSA-69242 S Phase 1.140838e-04 3.943
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 1.160499e-04 3.935
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 1.160499e-04 3.935
R-HSA-5357905 Regulation of TNFR1 signaling 1.214417e-04 3.916
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 1.214417e-04 3.916
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.451279e-04 3.838
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.508931e-04 3.821
R-HSA-71291 Metabolism of amino acids and derivatives 1.509373e-04 3.821
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 1.558654e-04 3.807
R-HSA-9612973 Autophagy 1.569062e-04 3.804
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 1.601419e-04 3.795
R-HSA-162587 HIV Life Cycle 1.630843e-04 3.788
R-HSA-72172 mRNA Splicing 1.664253e-04 3.779
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 1.694615e-04 3.771
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1.697915e-04 3.770
R-HSA-69620 Cell Cycle Checkpoints 1.759670e-04 3.755
R-HSA-8878166 Transcriptional regulation by RUNX2 1.808595e-04 3.743
R-HSA-5633007 Regulation of TP53 Activity 1.828328e-04 3.738
R-HSA-5689901 Metalloprotease DUBs 1.927342e-04 3.715
R-HSA-9637687 Suppression of phagosomal maturation 1.927342e-04 3.715
R-HSA-1643713 Signaling by EGFR in Cancer 1.927342e-04 3.715
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 1.972934e-04 3.705
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.015252e-04 3.696
R-HSA-901032 ER Quality Control Compartment (ERQC) 2.165225e-04 3.664
R-HSA-72649 Translation initiation complex formation 2.292475e-04 3.640
R-HSA-1236974 ER-Phagosome pathway 2.377642e-04 3.624
R-HSA-5654732 Negative regulation of FGFR3 signaling 2.423550e-04 3.616
R-HSA-202424 Downstream TCR signaling 2.509203e-04 3.600
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 2.703326e-04 3.568
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 2.649951e-04 3.577
R-HSA-6782135 Dual incision in TC-NER 3.048256e-04 3.516
R-HSA-75893 TNF signaling 2.649951e-04 3.577
R-HSA-8863795 Downregulation of ERBB2 signaling 3.005569e-04 3.522
R-HSA-162588 Budding and maturation of HIV virion 3.331308e-04 3.477
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 3.048256e-04 3.516
R-HSA-177929 Signaling by EGFR 2.649951e-04 3.577
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 3.681581e-04 3.434
R-HSA-450294 MAP kinase activation 3.728824e-04 3.428
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 2.649951e-04 3.577
R-HSA-5654733 Negative regulation of FGFR4 signaling 2.703326e-04 3.568
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 3.028283e-04 3.519
R-HSA-9764265 Regulation of CDH1 Expression and Function 3.028283e-04 3.519
R-HSA-1227986 Signaling by ERBB2 3.490377e-04 3.457
R-HSA-9833109 Evasion by RSV of host interferon responses 3.331308e-04 3.477
R-HSA-5607764 CLEC7A (Dectin-1) signaling 3.780236e-04 3.422
R-HSA-5621481 C-type lectin receptors (CLRs) 2.825436e-04 3.549
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 3.423552e-04 3.466
R-HSA-9909396 Circadian clock 3.432509e-04 3.464
R-HSA-5683057 MAPK family signaling cascades 3.950341e-04 3.403
R-HSA-9705683 SARS-CoV-2-host interactions 3.493716e-04 3.457
R-HSA-68867 Assembly of the pre-replicative complex 3.093790e-04 3.510
R-HSA-9674555 Signaling by CSF3 (G-CSF) 2.703326e-04 3.568
R-HSA-170834 Signaling by TGF-beta Receptor Complex 3.969145e-04 3.401
R-HSA-8878159 Transcriptional regulation by RUNX3 3.969145e-04 3.401
R-HSA-5673001 RAF/MAP kinase cascade 4.038845e-04 3.394
R-HSA-5675482 Regulation of necroptotic cell death 4.057430e-04 3.392
R-HSA-5654726 Negative regulation of FGFR1 signaling 4.057430e-04 3.392
R-HSA-3858494 Beta-catenin independent WNT signaling 4.179266e-04 3.379
R-HSA-201681 TCF dependent signaling in response to WNT 4.229209e-04 3.374
R-HSA-8848021 Signaling by PTK6 4.242455e-04 3.372
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.242455e-04 3.372
R-HSA-5696394 DNA Damage Recognition in GG-NER 4.459909e-04 3.351
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.518438e-04 3.345
R-HSA-5696400 Dual Incision in GG-NER 4.890076e-04 3.311
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 4.890076e-04 3.311
R-HSA-5654727 Negative regulation of FGFR2 signaling 4.890076e-04 3.311
R-HSA-901042 Calnexin/calreticulin cycle 4.890076e-04 3.311
R-HSA-1980145 Signaling by NOTCH2 4.890076e-04 3.311
R-HSA-983712 Ion channel transport 5.118725e-04 3.291
R-HSA-2559585 Oncogene Induced Senescence 5.348996e-04 3.272
R-HSA-5218859 Regulated Necrosis 5.759704e-04 3.240
R-HSA-9682385 FLT3 signaling in disease 5.837737e-04 3.234
R-HSA-72163 mRNA Splicing - Major Pathway 5.970858e-04 3.224
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.021849e-04 3.220
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 6.342304e-04 3.198
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 6.357374e-04 3.197
R-HSA-448424 Interleukin-17 signaling 6.468619e-04 3.189
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 6.468619e-04 3.189
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.863239e-04 3.163
R-HSA-1236975 Antigen processing-Cross presentation 6.863239e-04 3.163
R-HSA-5213460 RIPK1-mediated regulated necrosis 6.908985e-04 3.161
R-HSA-975155 MyD88 dependent cascade initiated on endosome 7.163033e-04 3.145
R-HSA-5688426 Deubiquitination 7.279210e-04 3.138
R-HSA-166166 MyD88-independent TLR4 cascade 7.472867e-04 3.127
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 7.472867e-04 3.127
R-HSA-202403 TCR signaling 7.472867e-04 3.127
R-HSA-9648002 RAS processing 7.493649e-04 3.125
R-HSA-8964043 Plasma lipoprotein clearance 7.493649e-04 3.125
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 7.652037e-04 3.116
R-HSA-446652 Interleukin-1 family signaling 7.739059e-04 3.111
R-HSA-69306 DNA Replication 8.006085e-04 3.097
R-HSA-5696395 Formation of Incision Complex in GG-NER 8.112450e-04 3.091
R-HSA-8982491 Glycogen metabolism 8.112450e-04 3.091
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 8.464886e-04 3.072
R-HSA-5357801 Programmed Cell Death 8.490036e-04 3.071
R-HSA-68886 M Phase 8.495804e-04 3.071
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 8.526171e-04 3.069
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.666946e-04 3.062
R-HSA-1980143 Signaling by NOTCH1 8.990144e-04 3.046
R-HSA-5675221 Negative regulation of MAPK pathway 9.456802e-04 3.024
R-HSA-9683701 Translation of Structural Proteins 9.456802e-04 3.024
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 9.555583e-04 3.020
R-HSA-9711123 Cellular response to chemical stress 1.003862e-03 2.998
R-HSA-109581 Apoptosis 1.075187e-03 2.969
R-HSA-5654743 Signaling by FGFR4 1.095073e-03 2.961
R-HSA-9637690 Response of Mtb to phagocytosis 1.095073e-03 2.961
R-HSA-5654738 Signaling by FGFR2 1.103609e-03 2.957
R-HSA-6806834 Signaling by MET 1.103609e-03 2.957
R-HSA-2467813 Separation of Sister Chromatids 1.145212e-03 2.941
R-HSA-5693607 Processing of DNA double-strand break ends 1.159742e-03 2.936
R-HSA-418990 Adherens junctions interactions 1.211772e-03 2.917
R-HSA-6783310 Fanconi Anemia Pathway 1.260292e-03 2.900
R-HSA-5654741 Signaling by FGFR3 1.260292e-03 2.900
R-HSA-8951664 Neddylation 1.310895e-03 2.882
R-HSA-9006925 Intracellular signaling by second messengers 1.336365e-03 2.874
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.340854e-03 2.873
R-HSA-72165 mRNA Splicing - Minor Pathway 1.349107e-03 2.870
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.349107e-03 2.870
R-HSA-9861718 Regulation of pyruvate metabolism 1.349107e-03 2.870
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 1.442204e-03 2.841
R-HSA-9909648 Regulation of PD-L1(CD274) expression 1.505837e-03 2.822
R-HSA-9694516 SARS-CoV-2 Infection 1.538021e-03 2.813
R-HSA-5689880 Ub-specific processing proteases 1.550819e-03 2.809
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.641674e-03 2.785
R-HSA-74160 Gene expression (Transcription) 1.770853e-03 2.752
R-HSA-2559583 Cellular Senescence 1.895783e-03 2.722
R-HSA-162582 Signal Transduction 2.025226e-03 2.694
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 2.222777e-03 2.653
R-HSA-9012852 Signaling by NOTCH3 2.353976e-03 2.628
R-HSA-5619115 Disorders of transmembrane transporters 2.468133e-03 2.608
R-HSA-5654736 Signaling by FGFR1 2.490411e-03 2.604
R-HSA-6807070 PTEN Regulation 2.572714e-03 2.590
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 2.630424e-03 2.580
R-HSA-421270 Cell-cell junction organization 2.701233e-03 2.568
R-HSA-975871 MyD88 cascade initiated on plasma membrane 2.785121e-03 2.555
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 2.785121e-03 2.555
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 2.785121e-03 2.555
R-HSA-190236 Signaling by FGFR 2.785121e-03 2.555
R-HSA-1500931 Cell-Cell communication 2.839585e-03 2.547
R-HSA-3295583 TRP channels 2.867262e-03 2.543
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 2.887491e-03 2.539
R-HSA-193704 p75 NTR receptor-mediated signalling 2.895315e-03 2.538
R-HSA-9033241 Peroxisomal protein import 2.932170e-03 2.533
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 2.932170e-03 2.533
R-HSA-913531 Interferon Signaling 2.950586e-03 2.530
R-HSA-388841 Regulation of T cell activation by CD28 family 3.016460e-03 2.521
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.090580e-03 2.510
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.090580e-03 2.510
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.090580e-03 2.510
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.090580e-03 2.510
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.090580e-03 2.510
R-HSA-2871837 FCERI mediated NF-kB activation 3.093756e-03 2.510
R-HSA-1280215 Cytokine Signaling in Immune system 3.113832e-03 2.507
R-HSA-168249 Innate Immune System 3.143026e-03 2.503
R-HSA-6798695 Neutrophil degranulation 3.209773e-03 2.494
R-HSA-389948 Co-inhibition by PD-1 3.215109e-03 2.493
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 3.461858e-03 2.461
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.482472e-03 2.458
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 3.494091e-03 2.457
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 3.600691e-03 2.444
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.717622e-03 2.430
R-HSA-1643685 Disease 3.719979e-03 2.429
R-HSA-5696398 Nucleotide Excision Repair 3.756845e-03 2.425
R-HSA-5693532 DNA Double-Strand Break Repair 4.018180e-03 2.396
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.033482e-03 2.394
R-HSA-9700206 Signaling by ALK in cancer 4.033482e-03 2.394
R-HSA-73887 Death Receptor Signaling 4.132258e-03 2.384
R-HSA-9958517 SLC-mediated bile acid transport 4.264734e-03 2.370
R-HSA-449147 Signaling by Interleukins 4.343848e-03 2.362
R-HSA-5693606 DNA Double Strand Break Response 4.365887e-03 2.360
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.365887e-03 2.360
R-HSA-168256 Immune System 4.643959e-03 2.333
R-HSA-446728 Cell junction organization 4.758455e-03 2.323
R-HSA-9006936 Signaling by TGFB family members 4.867770e-03 2.313
R-HSA-9613354 Lipophagy 5.046695e-03 2.297
R-HSA-2465910 MASTL Facilitates Mitotic Progression 5.046695e-03 2.297
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.116768e-03 2.291
R-HSA-399956 CRMPs in Sema3A signaling 1.097622e-02 1.960
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.708256e-03 2.243
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 8.197681e-03 2.086
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 8.833613e-03 2.054
R-HSA-9907900 Proteasome assembly 1.085211e-02 1.964
R-HSA-3371556 Cellular response to heat stress 6.793725e-03 2.168
R-HSA-168898 Toll-like Receptor Cascades 1.050256e-02 1.979
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 9.845951e-03 2.007
R-HSA-195721 Signaling by WNT 6.934269e-03 2.159
R-HSA-3928662 EPHB-mediated forward signaling 1.085211e-02 1.964
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.391862e-03 2.194
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.391862e-03 2.194
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 7.001152e-03 2.155
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 7.001152e-03 2.155
R-HSA-73894 DNA Repair 6.255727e-03 2.204
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 5.889398e-03 2.230
R-HSA-977225 Amyloid fiber formation 7.891311e-03 2.103
R-HSA-69205 G1/S-Specific Transcription 6.492095e-03 2.188
R-HSA-111933 Calmodulin induced events 6.492095e-03 2.188
R-HSA-111997 CaM pathway 6.492095e-03 2.188
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.085211e-02 1.964
R-HSA-111996 Ca-dependent events 9.768892e-03 2.010
R-HSA-3700989 Transcriptional Regulation by TP53 1.032924e-02 1.986
R-HSA-157118 Signaling by NOTCH 7.994062e-03 2.097
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 7.301380e-03 2.137
R-HSA-5693538 Homology Directed Repair 6.197332e-03 2.208
R-HSA-70268 Pyruvate metabolism 1.020032e-02 1.991
R-HSA-1236394 Signaling by ERBB4 5.955857e-03 2.225
R-HSA-917937 Iron uptake and transport 6.210512e-03 2.207
R-HSA-5663084 Diseases of carbohydrate metabolism 5.708256e-03 2.243
R-HSA-9694635 Translation of Structural Proteins 6.741330e-03 2.171
R-HSA-1489509 DAG and IP3 signaling 1.141874e-02 1.942
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 1.152992e-02 1.938
R-HSA-8876725 Protein methylation 1.216088e-02 1.915
R-HSA-9679506 SARS-CoV Infections 1.222656e-02 1.913
R-HSA-9772573 Late SARS-CoV-2 Infection Events 1.249588e-02 1.903
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 1.249588e-02 1.903
R-HSA-437239 Recycling pathway of L1 1.260244e-02 1.900
R-HSA-73857 RNA Polymerase II Transcription 1.304214e-02 1.885
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.340034e-02 1.873
R-HSA-382551 Transport of small molecules 1.389711e-02 1.857
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 1.468930e-02 1.833
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1.468930e-02 1.833
R-HSA-3371571 HSF1-dependent transactivation 1.517358e-02 1.819
R-HSA-72187 mRNA 3'-end processing 1.585915e-02 1.800
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 1.603108e-02 1.795
R-HSA-5602566 TICAM1 deficiency - HSE 1.723883e-02 1.763
R-HSA-77042 Formation of editosomes by ADAR proteins 1.723883e-02 1.763
R-HSA-9609507 Protein localization 1.734173e-02 1.761
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.742328e-02 1.759
R-HSA-2559580 Oxidative Stress Induced Senescence 1.751026e-02 1.757
R-HSA-111885 Opioid Signalling 1.853848e-02 1.732
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.886492e-02 1.724
R-HSA-9833110 RSV-host interactions 1.906637e-02 1.720
R-HSA-2980766 Nuclear Envelope Breakdown 1.954588e-02 1.709
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.954588e-02 1.709
R-HSA-1257604 PIP3 activates AKT signaling 2.079117e-02 1.682
R-HSA-8878171 Transcriptional regulation by RUNX1 2.114621e-02 1.675
R-HSA-210991 Basigin interactions 2.189279e-02 1.660
R-HSA-73856 RNA Polymerase II Transcription Termination 2.280733e-02 1.642
R-HSA-112043 PLC beta mediated events 2.280733e-02 1.642
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 2.347715e-02 1.629
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 2.347715e-02 1.629
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 2.347715e-02 1.629
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.347715e-02 1.629
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 2.347715e-02 1.629
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 2.347715e-02 1.629
R-HSA-166208 mTORC1-mediated signalling 2.510725e-02 1.600
R-HSA-5602571 TRAF3 deficiency - HSE 2.574726e-02 1.589
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 2.678219e-02 1.572
R-HSA-909733 Interferon alpha/beta signaling 2.678338e-02 1.572
R-HSA-373760 L1CAM interactions 2.744387e-02 1.562
R-HSA-392499 Metabolism of proteins 2.801900e-02 1.553
R-HSA-112040 G-protein mediated events 2.822049e-02 1.549
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.850108e-02 1.545
R-HSA-68875 Mitotic Prophase 3.018290e-02 1.520
R-HSA-9620244 Long-term potentiation 3.026304e-02 1.519
R-HSA-9635486 Infection with Mycobacterium tuberculosis 3.089203e-02 1.510
R-HSA-212165 Epigenetic regulation of gene expression 3.101475e-02 1.508
R-HSA-212436 Generic Transcription Pathway 3.157155e-02 1.501
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 3.206721e-02 1.494
R-HSA-199991 Membrane Trafficking 3.231558e-02 1.491
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.391275e-02 1.470
R-HSA-9006115 Signaling by NTRK2 (TRKB) 3.391275e-02 1.470
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 3.418256e-02 1.466
R-HSA-75064 mRNA Editing: A to I Conversion 3.418256e-02 1.466
R-HSA-75102 C6 deamination of adenosine 3.418256e-02 1.466
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 3.579881e-02 1.446
R-HSA-113418 Formation of the Early Elongation Complex 3.579881e-02 1.446
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 3.772456e-02 1.423
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.207190e-02 1.376
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 4.254534e-02 1.371
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 4.373183e-02 1.359
R-HSA-1280218 Adaptive Immune System 4.516225e-02 1.345
R-HSA-159227 Transport of the SLBP independent Mature mRNA 4.580828e-02 1.339
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 4.580828e-02 1.339
R-HSA-9930044 Nuclear RNA decay 4.580828e-02 1.339
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 4.580828e-02 1.339
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 4.792044e-02 1.319
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 4.792044e-02 1.319
R-HSA-9658195 Leishmania infection 4.861349e-02 1.313
R-HSA-9824443 Parasitic Infection Pathways 4.861349e-02 1.313
R-HSA-9768919 NPAS4 regulates expression of target genes 5.006755e-02 1.300
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 5.083622e-02 1.294
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 5.083622e-02 1.294
R-HSA-9706374 FLT3 signaling through SRC family kinases 5.083622e-02 1.294
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 5.224885e-02 1.282
R-HSA-432720 Lysosome Vesicle Biogenesis 5.446361e-02 1.264
R-HSA-3371511 HSF1 activation 5.446361e-02 1.264
R-HSA-163560 Triglyceride catabolism 5.446361e-02 1.264
R-HSA-8986944 Transcriptional Regulation by MECP2 5.735476e-02 1.241
R-HSA-166520 Signaling by NTRKs 5.776248e-02 1.238
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 5.899054e-02 1.229
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 5.899054e-02 1.229
R-HSA-68911 G2 Phase 5.905582e-02 1.229
R-HSA-9032759 NTRK2 activates RAC1 5.905582e-02 1.229
R-HSA-203754 NOSIP mediated eNOS trafficking 5.905582e-02 1.229
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 5.905582e-02 1.229
R-HSA-74713 IRS activation 5.905582e-02 1.229
R-HSA-8866376 Reelin signalling pathway 5.905582e-02 1.229
R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 5.905582e-02 1.229
R-HSA-2682334 EPH-Ephrin signaling 6.012542e-02 1.221
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 6.130129e-02 1.213
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 6.130129e-02 1.213
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 6.130129e-02 1.213
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 6.364261e-02 1.196
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 6.364261e-02 1.196
R-HSA-167169 HIV Transcription Elongation 6.364261e-02 1.196
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 6.364261e-02 1.196
R-HSA-3371568 Attenuation phase 6.364261e-02 1.196
R-HSA-177243 Interactions of Rev with host cellular proteins 6.364261e-02 1.196
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 6.405193e-02 1.193
R-HSA-5218920 VEGFR2 mediated vascular permeability 6.601382e-02 1.180
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 6.720474e-02 1.173
R-HSA-8849470 PTK6 Regulates Cell Cycle 6.720474e-02 1.173
R-HSA-176417 Phosphorylation of Emi1 6.720474e-02 1.173
R-HSA-9764302 Regulation of CDH19 Expression and Function 6.720474e-02 1.173
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 6.841422e-02 1.165
R-HSA-165159 MTOR signalling 7.084315e-02 1.150
R-HSA-1433557 Signaling by SCF-KIT 7.329994e-02 1.135
R-HSA-69478 G2/M DNA replication checkpoint 7.528358e-02 1.123
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 7.528358e-02 1.123
R-HSA-199920 CREB phosphorylation 7.528358e-02 1.123
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 7.528358e-02 1.123
R-HSA-164944 Nef and signal transduction 7.528358e-02 1.123
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 7.528358e-02 1.123
R-HSA-373752 Netrin-1 signaling 7.578394e-02 1.120
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.644814e-02 1.117
R-HSA-9824272 Somitogenesis 7.829448e-02 1.106
R-HSA-203641 NOSTRIN mediated eNOS trafficking 8.329295e-02 1.079
R-HSA-2562578 TRIF-mediated programmed cell death 8.329295e-02 1.079
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 8.329295e-02 1.079
R-HSA-9032845 Activated NTRK2 signals through CDK5 8.329295e-02 1.079
R-HSA-5576890 Phase 3 - rapid repolarisation 8.329295e-02 1.079
R-HSA-447041 CHL1 interactions 8.329295e-02 1.079
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 8.339271e-02 1.079
R-HSA-1483191 Synthesis of PC 8.339271e-02 1.079
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 8.774453e-02 1.057
R-HSA-9032500 Activated NTRK2 signals through FYN 9.123344e-02 1.040
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 9.123344e-02 1.040
R-HSA-112382 Formation of RNA Pol II elongation complex 9.655940e-02 1.015
R-HSA-9634815 Transcriptional Regulation by NPAS4 9.655940e-02 1.015
R-HSA-201688 WNT mediated activation of DVL 9.910564e-02 1.004
R-HSA-2025928 Calcineurin activates NFAT 9.910564e-02 1.004
R-HSA-448706 Interleukin-1 processing 9.910564e-02 1.004
R-HSA-75072 mRNA Editing 9.910564e-02 1.004
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 9.910564e-02 1.004
R-HSA-75955 RNA Polymerase II Transcription Elongation 9.926016e-02 1.003
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 9.926016e-02 1.003
R-HSA-432722 Golgi Associated Vesicle Biogenesis 9.926016e-02 1.003
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.032308e-01 0.986
R-HSA-9762292 Regulation of CDH11 function 1.069101e-01 0.971
R-HSA-6803544 Ion influx/efflux at host-pathogen interface 1.069101e-01 0.971
R-HSA-110056 MAPK3 (ERK1) activation 1.069101e-01 0.971
R-HSA-74749 Signal attenuation 1.069101e-01 0.971
R-HSA-5653656 Vesicle-mediated transport 1.081630e-01 0.966
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 1.130361e-01 0.947
R-HSA-9706019 RHOBTB3 ATPase cycle 1.146475e-01 0.941
R-HSA-210990 PECAM1 interactions 1.146475e-01 0.941
R-HSA-429914 Deadenylation-dependent mRNA decay 1.158890e-01 0.936
R-HSA-191859 snRNP Assembly 1.158890e-01 0.936
R-HSA-194441 Metabolism of non-coding RNA 1.158890e-01 0.936
R-HSA-8979227 Triglyceride metabolism 1.158890e-01 0.936
R-HSA-351202 Metabolism of polyamines 1.187261e-01 0.925
R-HSA-9793380 Formation of paraxial mesoderm 1.215806e-01 0.915
R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.223183e-01 0.913
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 1.235033e-01 0.908
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 1.235033e-01 0.908
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 1.235033e-01 0.908
R-HSA-194138 Signaling by VEGF 1.235033e-01 0.908
R-HSA-375165 NCAM signaling for neurite out-growth 1.244519e-01 0.905
R-HSA-9616222 Transcriptional regulation of granulopoiesis 1.244519e-01 0.905
R-HSA-373755 Semaphorin interactions 1.273396e-01 0.895
R-HSA-187037 Signaling by NTRK1 (TRKA) 1.292678e-01 0.889
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.299231e-01 0.886
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1.299231e-01 0.886
R-HSA-418890 Role of second messengers in netrin-1 signaling 1.299231e-01 0.886
R-HSA-5576891 Cardiac conduction 1.370997e-01 0.863
R-HSA-170660 Adenylate cyclase activating pathway 1.374625e-01 0.862
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 1.374625e-01 0.862
R-HSA-389359 CD28 dependent Vav1 pathway 1.374625e-01 0.862
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 1.374625e-01 0.862
R-HSA-75892 Platelet Adhesion to exposed collagen 1.374625e-01 0.862
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.374625e-01 0.862
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.374625e-01 0.862
R-HSA-167172 Transcription of the HIV genome 1.420063e-01 0.848
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.420063e-01 0.848
R-HSA-177504 Retrograde neurotrophin signalling 1.449370e-01 0.839
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.449370e-01 0.839
R-HSA-1433559 Regulation of KIT signaling 1.449370e-01 0.839
R-HSA-5578768 Physiological factors 1.449370e-01 0.839
R-HSA-9828642 Respiratory syncytial virus genome transcription 1.449370e-01 0.839
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 1.509721e-01 0.821
R-HSA-170670 Adenylate cyclase inhibitory pathway 1.523472e-01 0.817
R-HSA-418885 DCC mediated attractive signaling 1.523472e-01 0.817
R-HSA-399954 Sema3A PAK dependent Axon repulsion 1.523472e-01 0.817
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.523472e-01 0.817
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.523472e-01 0.817
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 1.523472e-01 0.817
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.523472e-01 0.817
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.523472e-01 0.817
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.539857e-01 0.813
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.539857e-01 0.813
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 1.539857e-01 0.813
R-HSA-9664407 Parasite infection 1.573556e-01 0.803
R-HSA-9664417 Leishmania phagocytosis 1.573556e-01 0.803
R-HSA-9664422 FCGR3A-mediated phagocytosis 1.573556e-01 0.803
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1.596936e-01 0.797
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.596936e-01 0.797
R-HSA-9664420 Killing mechanisms 1.596936e-01 0.797
R-HSA-176412 Phosphorylation of the APC/C 1.596936e-01 0.797
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.596936e-01 0.797
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1.596936e-01 0.797
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 1.596936e-01 0.797
R-HSA-9678110 Attachment and Entry 1.596936e-01 0.797
R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.600475e-01 0.796
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.669768e-01 0.777
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 1.692210e-01 0.772
R-HSA-6783783 Interleukin-10 signaling 1.722987e-01 0.764
R-HSA-9955298 SLC-mediated transport of organic anions 1.722987e-01 0.764
R-HSA-139853 Elevation of cytosolic Ca2+ levels 1.741974e-01 0.759
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.784816e-01 0.748
R-HSA-9833482 PKR-mediated signaling 1.784816e-01 0.748
R-HSA-3928664 Ephrin signaling 1.813558e-01 0.741
R-HSA-164378 PKA activation in glucagon signalling 1.813558e-01 0.741
R-HSA-156711 Polo-like kinase mediated events 1.813558e-01 0.741
R-HSA-163615 PKA activation 1.813558e-01 0.741
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.813558e-01 0.741
R-HSA-8851708 Signaling by FGFR2 IIIa TM 1.884525e-01 0.725
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.884525e-01 0.725
R-HSA-113510 E2F mediated regulation of DNA replication 1.884525e-01 0.725
R-HSA-449836 Other interleukin signaling 1.884525e-01 0.725
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 1.954882e-01 0.709
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 1.954882e-01 0.709
R-HSA-373753 Nephrin family interactions 1.954882e-01 0.709
R-HSA-389513 Co-inhibition by CTLA4 1.954882e-01 0.709
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.024634e-01 0.694
R-HSA-198753 ERK/MAPK targets 2.024634e-01 0.694
R-HSA-111931 PKA-mediated phosphorylation of CREB 2.024634e-01 0.694
R-HSA-438064 Post NMDA receptor activation events 2.035246e-01 0.691
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 2.093785e-01 0.679
R-HSA-9694614 Attachment and Entry 2.093785e-01 0.679
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.130187e-01 0.672
R-HSA-6803529 FGFR2 alternative splicing 2.162340e-01 0.665
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 2.162340e-01 0.665
R-HSA-9669938 Signaling by KIT in disease 2.162340e-01 0.665
R-HSA-112409 RAF-independent MAPK1/3 activation 2.162340e-01 0.665
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 2.230305e-01 0.652
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.297685e-01 0.639
R-HSA-429947 Deadenylation of mRNA 2.297685e-01 0.639
R-HSA-8863678 Neurodegenerative Diseases 2.297685e-01 0.639
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.297685e-01 0.639
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 2.347369e-01 0.629
R-HSA-9932451 SWI/SNF chromatin remodelers 2.364485e-01 0.626
R-HSA-9932444 ATP-dependent chromatin remodelers 2.364485e-01 0.626
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.364514e-01 0.626
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.430710e-01 0.614
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 2.430710e-01 0.614
R-HSA-9614085 FOXO-mediated transcription 2.481294e-01 0.605
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.496364e-01 0.603
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.496364e-01 0.603
R-HSA-3928663 EPHA-mediated growth cone collapse 2.496364e-01 0.603
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.496364e-01 0.603
R-HSA-389357 CD28 dependent PI3K/Akt signaling 2.496364e-01 0.603
R-HSA-70171 Glycolysis 2.513358e-01 0.600
R-HSA-167287 HIV elongation arrest and recovery 2.561453e-01 0.592
R-HSA-167290 Pausing and recovery of HIV elongation 2.561453e-01 0.592
R-HSA-5576892 Phase 0 - rapid depolarisation 2.561453e-01 0.592
R-HSA-171319 Telomere Extension By Telomerase 2.561453e-01 0.592
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 2.561453e-01 0.592
R-HSA-5620971 Pyroptosis 2.561453e-01 0.592
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 2.577519e-01 0.589
R-HSA-209968 Thyroxine biosynthesis 2.625982e-01 0.581
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.625982e-01 0.581
R-HSA-72086 mRNA Capping 2.625982e-01 0.581
R-HSA-9759475 Regulation of CDH11 Expression and Function 2.625982e-01 0.581
R-HSA-418360 Platelet calcium homeostasis 2.625982e-01 0.581
R-HSA-180024 DARPP-32 events 2.625982e-01 0.581
R-HSA-9860931 Response of endothelial cells to shear stress 2.641708e-01 0.578
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.689954e-01 0.570
R-HSA-2424491 DAP12 signaling 2.689954e-01 0.570
R-HSA-68962 Activation of the pre-replicative complex 2.689954e-01 0.570
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.689954e-01 0.570
R-HSA-888590 GABA synthesis, release, reuptake and degradation 2.689954e-01 0.570
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.753376e-01 0.560
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.753376e-01 0.560
R-HSA-399719 Trafficking of AMPA receptors 2.753376e-01 0.560
R-HSA-9675126 Diseases of mitotic cell cycle 2.816251e-01 0.550
R-HSA-9824439 Bacterial Infection Pathways 2.873833e-01 0.542
R-HSA-1855170 IPs transport between nucleus and cytosol 2.878584e-01 0.541
R-HSA-176187 Activation of ATR in response to replication stress 2.878584e-01 0.541
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.878584e-01 0.541
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 2.878584e-01 0.541
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 2.878584e-01 0.541
R-HSA-9022692 Regulation of MECP2 expression and activity 2.878584e-01 0.541
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 2.940380e-01 0.532
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.940380e-01 0.532
R-HSA-163359 Glucagon signaling in metabolic regulation 2.940380e-01 0.532
R-HSA-114508 Effects of PIP2 hydrolysis 2.940380e-01 0.532
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.971752e-01 0.527
R-HSA-9855142 Cellular responses to mechanical stimuli 2.994395e-01 0.524
R-HSA-180746 Nuclear import of Rev protein 3.001644e-01 0.523
R-HSA-203615 eNOS activation 3.001644e-01 0.523
R-HSA-5673000 RAF activation 3.001644e-01 0.523
R-HSA-381042 PERK regulates gene expression 3.062380e-01 0.514
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.062380e-01 0.514
R-HSA-114604 GPVI-mediated activation cascade 3.122593e-01 0.505
R-HSA-1839126 FGFR2 mutant receptor activation 3.122593e-01 0.505
R-HSA-8853659 RET signaling 3.122593e-01 0.505
R-HSA-70326 Glucose metabolism 3.153984e-01 0.501
R-HSA-1296072 Voltage gated Potassium channels 3.182287e-01 0.497
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.182287e-01 0.497
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.279579e-01 0.484
R-HSA-397014 Muscle contraction 3.279579e-01 0.484
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.281090e-01 0.484
R-HSA-73886 Chromosome Maintenance 3.281090e-01 0.484
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 3.300135e-01 0.481
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.300135e-01 0.481
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 3.300135e-01 0.481
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.358299e-01 0.474
R-HSA-5602358 Diseases associated with the TLR signaling cascade 3.358299e-01 0.474
R-HSA-5260271 Diseases of Immune System 3.358299e-01 0.474
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.415961e-01 0.466
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.415961e-01 0.466
R-HSA-3214841 PKMTs methylate histone lysines 3.415961e-01 0.466
R-HSA-446203 Asparagine N-linked glycosylation 3.417501e-01 0.466
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 3.470542e-01 0.460
R-HSA-9656223 Signaling by RAF1 mutants 3.473126e-01 0.459
R-HSA-112315 Transmission across Chemical Synapses 3.486951e-01 0.458
R-HSA-8957322 Metabolism of steroids 3.506638e-01 0.455
R-HSA-991365 Activation of GABAB receptors 3.529799e-01 0.452
R-HSA-977444 GABA B receptor activation 3.529799e-01 0.452
R-HSA-2172127 DAP12 interactions 3.641682e-01 0.439
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.696901e-01 0.432
R-HSA-774815 Nucleosome assembly 3.696901e-01 0.432
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.696901e-01 0.432
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 3.696901e-01 0.432
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 3.696901e-01 0.432
R-HSA-2299718 Condensation of Prophase Chromosomes 3.751644e-01 0.426
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.751644e-01 0.426
R-HSA-9649948 Signaling downstream of RAS mutants 3.751644e-01 0.426
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.751644e-01 0.426
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.751644e-01 0.426
R-HSA-6802949 Signaling by RAS mutants 3.751644e-01 0.426
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 3.751644e-01 0.426
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 3.751644e-01 0.426
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.805915e-01 0.420
R-HSA-1428517 Aerobic respiration and respiratory electron transport 3.841194e-01 0.416
R-HSA-389356 Co-stimulation by CD28 3.859717e-01 0.413
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.859717e-01 0.413
R-HSA-9634597 GPER1 signaling 3.859717e-01 0.413
R-HSA-70263 Gluconeogenesis 3.859717e-01 0.413
R-HSA-425410 Metal ion SLC transporters 3.859717e-01 0.413
R-HSA-9031628 NGF-stimulated transcription 3.859717e-01 0.413
R-HSA-202733 Cell surface interactions at the vascular wall 3.869868e-01 0.412
R-HSA-597592 Post-translational protein modification 3.892386e-01 0.410
R-HSA-5655253 Signaling by FGFR2 in disease 3.965935e-01 0.402
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.996789e-01 0.398
R-HSA-912446 Meiotic recombination 4.018358e-01 0.396
R-HSA-4839726 Chromatin organization 4.149456e-01 0.382
R-HSA-112316 Neuronal System 4.208923e-01 0.376
R-HSA-418597 G alpha (z) signalling events 4.223564e-01 0.374
R-HSA-9758941 Gastrulation 4.267502e-01 0.370
R-HSA-9006931 Signaling by Nuclear Receptors 4.271088e-01 0.369
R-HSA-209776 Metabolism of amine-derived hormones 4.273764e-01 0.369
R-HSA-193648 NRAGE signals death through JNK 4.273764e-01 0.369
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 4.273764e-01 0.369
R-HSA-5578775 Ion homeostasis 4.273764e-01 0.369
R-HSA-9856651 MITF-M-dependent gene expression 4.297196e-01 0.367
R-HSA-5621480 Dectin-2 family 4.323531e-01 0.364
R-HSA-9772572 Early SARS-CoV-2 Infection Events 4.372868e-01 0.359
R-HSA-180786 Extension of Telomeres 4.421780e-01 0.354
R-HSA-352230 Amino acid transport across the plasma membrane 4.421780e-01 0.354
R-HSA-1989781 PPARA activates gene expression 4.444446e-01 0.352
R-HSA-977443 GABA receptor activation 4.470269e-01 0.350
R-HSA-9734767 Developmental Cell Lineages 4.470458e-01 0.350
R-HSA-9610379 HCMV Late Events 4.502761e-01 0.347
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 4.502761e-01 0.347
R-HSA-168325 Viral Messenger RNA Synthesis 4.518340e-01 0.345
R-HSA-1442490 Collagen degradation 4.518340e-01 0.345
R-HSA-445717 Aquaporin-mediated transport 4.518340e-01 0.345
R-HSA-6784531 tRNA processing in the nucleus 4.565996e-01 0.340
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.565996e-01 0.340
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.613241e-01 0.336
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.613241e-01 0.336
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.613241e-01 0.336
R-HSA-74751 Insulin receptor signalling cascade 4.660077e-01 0.332
R-HSA-936837 Ion transport by P-type ATPases 4.660077e-01 0.332
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 4.706510e-01 0.327
R-HSA-8854518 AURKA Activation by TPX2 4.752541e-01 0.323
R-HSA-9958863 SLC-mediated transport of amino acids 4.798175e-01 0.319
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 4.843415e-01 0.315
R-HSA-75105 Fatty acyl-CoA biosynthesis 4.932727e-01 0.307
R-HSA-425407 SLC-mediated transmembrane transport 4.937704e-01 0.306
R-HSA-427413 NoRC negatively regulates rRNA expression 4.976805e-01 0.303
R-HSA-9664433 Leishmania parasite growth and survival 4.984081e-01 0.302
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 4.984081e-01 0.302
R-HSA-5578749 Transcriptional regulation by small RNAs 5.020502e-01 0.299
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 5.038941e-01 0.298
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.063822e-01 0.296
R-HSA-69473 G2/M DNA damage checkpoint 5.106768e-01 0.292
R-HSA-1222556 ROS and RNS production in phagocytes 5.106768e-01 0.292
R-HSA-1226099 Signaling by FGFR in disease 5.106768e-01 0.292
R-HSA-418594 G alpha (i) signalling events 5.122503e-01 0.291
R-HSA-380287 Centrosome maturation 5.149342e-01 0.288
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 5.274872e-01 0.278
R-HSA-416482 G alpha (12/13) signalling events 5.274872e-01 0.278
R-HSA-191273 Cholesterol biosynthesis 5.274872e-01 0.278
R-HSA-9659379 Sensory processing of sound 5.315994e-01 0.274
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 5.356761e-01 0.271
R-HSA-5617833 Cilium Assembly 5.437938e-01 0.265
R-HSA-5668914 Diseases of metabolism 5.482695e-01 0.261
R-HSA-68877 Mitotic Prometaphase 5.515044e-01 0.258
R-HSA-6802957 Oncogenic MAPK signaling 5.555372e-01 0.255
R-HSA-1500620 Meiosis 5.555372e-01 0.255
R-HSA-141424 Amplification of signal from the kinetochores 5.594070e-01 0.252
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 5.594070e-01 0.252
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 5.632433e-01 0.249
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.708168e-01 0.244
R-HSA-9645723 Diseases of programmed cell death 5.708168e-01 0.244
R-HSA-1483206 Glycerophospholipid biosynthesis 5.765454e-01 0.239
R-HSA-112310 Neurotransmitter release cycle 5.782598e-01 0.238
R-HSA-74752 Signaling by Insulin receptor 5.891848e-01 0.230
R-HSA-2029481 FCGR activation 5.927636e-01 0.227
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 5.927636e-01 0.227
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 5.963115e-01 0.225
R-HSA-9730414 MITF-M-regulated melanocyte development 6.029054e-01 0.220
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 6.067721e-01 0.217
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 6.067721e-01 0.217
R-HSA-1296071 Potassium Channels 6.067721e-01 0.217
R-HSA-157579 Telomere Maintenance 6.101988e-01 0.215
R-HSA-3214847 HATs acetylate histones 6.169635e-01 0.210
R-HSA-69618 Mitotic Spindle Checkpoint 6.203020e-01 0.207
R-HSA-9009391 Extra-nuclear estrogen signaling 6.236116e-01 0.205
R-HSA-418346 Platelet homeostasis 6.428763e-01 0.192
R-HSA-211000 Gene Silencing by RNA 6.459905e-01 0.190
R-HSA-3247509 Chromatin modifying enzymes 6.497748e-01 0.187
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 6.521383e-01 0.186
R-HSA-8939211 ESR-mediated signaling 6.561031e-01 0.183
R-HSA-6803157 Antimicrobial peptides 6.581800e-01 0.182
R-HSA-1483249 Inositol phosphate metabolism 6.611617e-01 0.180
R-HSA-2980736 Peptide hormone metabolism 6.813226e-01 0.167
R-HSA-9609646 HCMV Infection 6.824826e-01 0.166
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.841038e-01 0.165
R-HSA-388396 GPCR downstream signalling 6.942258e-01 0.158
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.976524e-01 0.156
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.976524e-01 0.156
R-HSA-2132295 MHC class II antigen presentation 6.976524e-01 0.156
R-HSA-6809371 Formation of the cornified envelope 7.002921e-01 0.155
R-HSA-109582 Hemostasis 7.056807e-01 0.151
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.181400e-01 0.144
R-HSA-1474165 Reproduction 7.206020e-01 0.142
R-HSA-1474228 Degradation of the extracellular matrix 7.254622e-01 0.139
R-HSA-8856688 Golgi-to-ER retrograde transport 7.254622e-01 0.139
R-HSA-76002 Platelet activation, signaling and aggregation 7.268513e-01 0.139
R-HSA-163685 Integration of energy metabolism 7.372485e-01 0.132
R-HSA-381119 Unfolded Protein Response (UPR) 7.440777e-01 0.128
R-HSA-1483257 Phospholipid metabolism 7.612968e-01 0.118
R-HSA-9679191 Potential therapeutics for SARS 7.696764e-01 0.114
R-HSA-372790 Signaling by GPCR 7.805222e-01 0.108
R-HSA-877300 Interferon gamma signaling 7.871917e-01 0.104
R-HSA-1852241 Organelle biogenesis and maintenance 7.973771e-01 0.098
R-HSA-1430728 Metabolism 7.991184e-01 0.097
R-HSA-5619102 SLC transporter disorders 8.016469e-01 0.096
R-HSA-72306 tRNA processing 8.085045e-01 0.092
R-HSA-418555 G alpha (s) signalling events 8.101818e-01 0.091
R-HSA-9609690 HCMV Early Events 8.476855e-01 0.072
R-HSA-6805567 Keratinization 8.617608e-01 0.065
R-HSA-416476 G alpha (q) signalling events 9.171843e-01 0.038
R-HSA-1474244 Extracellular matrix organization 9.542862e-01 0.020
R-HSA-556833 Metabolism of lipids 9.568472e-01 0.019
R-HSA-8978868 Fatty acid metabolism 9.769800e-01 0.010
R-HSA-9709957 Sensory Perception 9.999887e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.863 0.234 1 0.895
PKRPKR 0.846 0.054 1 0.821
VRK2VRK2 0.844 -0.149 1 0.877
PDHK3_TYRPDHK3_TYR 0.842 0.229 4 0.900
GCKGCK 0.841 0.038 1 0.796
ALK4ALK4 0.840 0.097 -2 0.850
BMPR2BMPR2 0.839 -0.038 -2 0.877
EEF2KEEF2K 0.839 0.042 3 0.840
TAK1TAK1 0.839 -0.087 1 0.810
MOSMOS 0.838 0.148 1 0.838
TTKTTK 0.837 0.033 -2 0.842
TNIKTNIK 0.837 0.027 3 0.847
MINKMINK 0.837 -0.009 1 0.785
ALPHAK3ALPHAK3 0.836 0.019 -1 0.775
BMPR2_TYRBMPR2_TYR 0.836 0.158 -1 0.890
ALK2ALK2 0.836 0.138 -2 0.835
TGFBR1TGFBR1 0.836 0.159 -2 0.834
MAP2K6_TYRMAP2K6_TYR 0.836 0.131 -1 0.874
NIKNIK 0.835 -0.024 -3 0.827
VRK1VRK1 0.835 -0.158 2 0.803
MEKK2MEKK2 0.835 -0.036 2 0.772
DAPK2DAPK2 0.835 0.004 -3 0.812
PDHK4_TYRPDHK4_TYR 0.835 0.116 2 0.881
PASKPASK 0.835 0.101 -3 0.812
LRRK2LRRK2 0.834 -0.133 2 0.832
PRPKPRPK 0.834 -0.002 -1 0.860
BMPR1BBMPR1B 0.834 0.199 1 0.762
TAO3TAO3 0.834 0.031 1 0.798
PDHK1_TYRPDHK1_TYR 0.833 0.089 -1 0.893
MAP2K4_TYRMAP2K4_TYR 0.833 0.043 -1 0.872
LATS1LATS1 0.833 0.120 -3 0.824
MEK1MEK1 0.833 -0.181 2 0.812
ASK1ASK1 0.832 -0.141 1 0.754
KHS2KHS2 0.832 0.070 1 0.785
CLK3CLK3 0.832 0.339 1 0.872
MST3MST3 0.832 0.052 2 0.818
KHS1KHS1 0.832 0.024 1 0.774
NLKNLK 0.831 0.120 1 0.875
BIKEBIKE 0.831 0.138 1 0.815
TAO2TAO2 0.831 -0.062 2 0.822
CDKL1CDKL1 0.831 0.126 -3 0.761
GRK7GRK7 0.831 0.191 1 0.818
JNK2JNK2 0.831 0.175 1 0.699
CAMLCKCAMLCK 0.831 -0.016 -2 0.812
PDK1PDK1 0.831 -0.074 1 0.792
EPHA6EPHA6 0.830 0.141 -1 0.870
P38AP38A 0.830 0.173 1 0.787
PKMYT1_TYRPKMYT1_TYR 0.830 0.034 3 0.837
CAMK1BCAMK1B 0.830 0.032 -3 0.817
MAP3K15MAP3K15 0.830 -0.081 1 0.765
MPSK1MPSK1 0.829 0.112 1 0.832
PRP4PRP4 0.829 0.151 -3 0.745
BRAFBRAF 0.829 -0.140 -4 0.797
FYNFYN 0.829 0.264 -1 0.860
DLKDLK 0.829 -0.125 1 0.829
YES1YES1 0.829 0.152 -1 0.856
NEK5NEK5 0.829 -0.100 1 0.831
HPK1HPK1 0.828 -0.004 1 0.775
TESK1_TYRTESK1_TYR 0.828 -0.068 3 0.860
JNK3JNK3 0.828 0.148 1 0.735
ANKRD3ANKRD3 0.828 -0.091 1 0.841
NEK1NEK1 0.828 -0.147 1 0.800
MAP2K7_TYRMAP2K7_TYR 0.828 -0.132 2 0.852
MST2MST2 0.828 -0.106 1 0.803
HGKHGK 0.828 -0.050 3 0.847
BLKBLK 0.827 0.241 -1 0.870
COTCOT 0.827 0.261 2 0.861
OSR1OSR1 0.827 -0.058 2 0.762
MEK5MEK5 0.827 -0.266 2 0.795
EPHB4EPHB4 0.826 0.096 -1 0.828
ICKICK 0.826 0.109 -3 0.787
LCKLCK 0.826 0.220 -1 0.862
FGRFGR 0.826 0.105 1 0.883
MEKK3MEKK3 0.826 -0.067 1 0.799
ACVR2BACVR2B 0.825 0.096 -2 0.817
SKMLCKSKMLCK 0.825 0.102 -2 0.848
P38BP38B 0.825 0.163 1 0.726
MST1MST1 0.825 -0.146 1 0.786
PINK1_TYRPINK1_TYR 0.825 -0.115 1 0.850
TXKTXK 0.824 0.151 1 0.808
MEKK1MEKK1 0.824 -0.136 1 0.803
ATRATR 0.824 -0.025 1 0.818
ACVR2AACVR2A 0.824 0.079 -2 0.799
HCKHCK 0.823 0.135 -1 0.852
MEKK6MEKK6 0.823 -0.122 1 0.797
AAK1AAK1 0.823 0.193 1 0.731
DMPK1DMPK1 0.823 0.079 -3 0.750
DAPK3DAPK3 0.823 0.033 -3 0.783
ABL2ABL2 0.822 0.063 -1 0.812
BMPR1ABMPR1A 0.822 0.163 1 0.734
EPHA4EPHA4 0.822 0.077 2 0.816
YSK4YSK4 0.822 -0.080 1 0.771
NEK11NEK11 0.822 -0.152 1 0.785
RETRET 0.821 -0.067 1 0.816
CSF1RCSF1R 0.821 0.016 3 0.785
CAMK2GCAMK2G 0.821 0.043 2 0.846
GRK6GRK6 0.821 0.066 1 0.835
MST1RMST1R 0.820 -0.052 3 0.809
LKB1LKB1 0.820 -0.175 -3 0.745
LIMK2_TYRLIMK2_TYR 0.820 -0.055 -3 0.812
MYO3BMYO3B 0.820 -0.057 2 0.795
MYO3AMYO3A 0.820 -0.084 1 0.763
ERK5ERK5 0.820 0.105 1 0.862
SRMSSRMS 0.819 0.077 1 0.842
PBKPBK 0.819 0.072 1 0.832
NEK8NEK8 0.819 -0.183 2 0.798
FERFER 0.819 -0.003 1 0.870
SMMLCKSMMLCK 0.818 -0.027 -3 0.767
ZAKZAK 0.818 -0.129 1 0.771
PIM1PIM1 0.818 0.162 -3 0.776
PLK1PLK1 0.818 -0.009 -2 0.818
YSK1YSK1 0.818 -0.088 2 0.778
CAMKK1CAMKK1 0.817 -0.248 -2 0.732
INSRRINSRR 0.817 0.010 3 0.744
PIM3PIM3 0.817 0.164 -3 0.816
ABL1ABL1 0.817 0.027 -1 0.802
TYRO3TYRO3 0.817 -0.073 3 0.790
TYK2TYK2 0.817 -0.129 1 0.814
P38GP38G 0.816 0.156 1 0.638
KITKIT 0.816 0.003 3 0.795
ROS1ROS1 0.816 -0.062 3 0.758
EPHB2EPHB2 0.816 0.081 -1 0.809
NEK4NEK4 0.816 -0.185 1 0.785
ITKITK 0.816 0.051 -1 0.800
MLK1MLK1 0.816 -0.028 2 0.795
RAF1RAF1 0.816 -0.103 1 0.827
DSTYKDSTYK 0.816 0.103 2 0.888
HIPK1HIPK1 0.815 0.155 1 0.783
FGFR2FGFR2 0.815 -0.026 3 0.796
JAK2JAK2 0.815 -0.100 1 0.809
DDR1DDR1 0.815 -0.116 4 0.842
METMET 0.815 0.032 3 0.786
CDK1CDK1 0.815 0.188 1 0.716
SRCSRC 0.815 0.146 -1 0.846
TLK2TLK2 0.815 -0.040 1 0.779
DAPK1DAPK1 0.814 0.028 -3 0.763
EPHB1EPHB1 0.814 0.021 1 0.828
TNK2TNK2 0.814 0.035 3 0.780
EPHB3EPHB3 0.814 0.034 -1 0.813
WNK1WNK1 0.814 0.056 -2 0.869
ROCK2ROCK2 0.813 0.020 -3 0.772
P38DP38D 0.813 0.169 1 0.647
KDRKDR 0.813 -0.018 3 0.759
JAK3JAK3 0.813 -0.069 1 0.793
CAMKK2CAMKK2 0.813 -0.285 -2 0.717
MAKMAK 0.813 0.195 -2 0.741
LIMK1_TYRLIMK1_TYR 0.813 -0.219 2 0.829
PTK2PTK2 0.813 0.164 -1 0.818
BMXBMX 0.812 0.036 -1 0.744
PKN3PKN3 0.812 0.048 -3 0.781
MLK2MLK2 0.812 -0.153 2 0.786
CDKL5CDKL5 0.812 0.134 -3 0.751
PERKPERK 0.811 -0.146 -2 0.830
GRK5GRK5 0.811 -0.107 -3 0.797
JNK1JNK1 0.811 0.131 1 0.696
EPHA7EPHA7 0.811 0.052 2 0.807
FLT3FLT3 0.811 -0.053 3 0.794
STLK3STLK3 0.811 -0.278 1 0.741
NUAK2NUAK2 0.811 0.093 -3 0.815
MERTKMERTK 0.811 -0.001 3 0.765
FRKFRK 0.811 0.062 -1 0.855
LYNLYN 0.810 0.089 3 0.715
CDK5CDK5 0.810 0.160 1 0.771
MTORMTOR 0.810 0.047 1 0.833
WNK4WNK4 0.809 -0.068 -2 0.868
PLK3PLK3 0.809 0.029 2 0.804
MEK2MEK2 0.809 -0.344 2 0.764
GRK1GRK1 0.809 0.174 -2 0.778
SYKSYK 0.809 0.149 -1 0.811
PDHK4PDHK4 0.809 -0.252 1 0.855
EGFREGFR 0.809 0.066 1 0.735
CHAK2CHAK2 0.809 -0.056 -1 0.812
TLK1TLK1 0.809 -0.106 -2 0.859
DYRK2DYRK2 0.809 0.148 1 0.761
EPHA8EPHA8 0.808 0.090 -1 0.826
MASTLMASTL 0.808 -0.238 -2 0.807
HRIHRI 0.808 -0.183 -2 0.847
FLT1FLT1 0.808 -0.023 -1 0.829
ERK2ERK2 0.807 0.071 1 0.757
TECTEC 0.807 -0.011 -1 0.738
NEK9NEK9 0.807 -0.163 2 0.804
CLK4CLK4 0.807 0.139 -3 0.761
FGFR3FGFR3 0.807 -0.028 3 0.772
ERBB2ERBB2 0.807 -0.038 1 0.805
DCAMKL1DCAMKL1 0.807 0.032 -3 0.776
MLK3MLK3 0.807 0.027 2 0.732
MST4MST4 0.807 0.071 2 0.826
FGFR1FGFR1 0.807 -0.090 3 0.771
PDGFRBPDGFRB 0.807 -0.123 3 0.805
PKCDPKCD 0.807 0.052 2 0.769
ERK1ERK1 0.807 0.131 1 0.716
RIPK3RIPK3 0.806 -0.061 3 0.733
LOKLOK 0.806 -0.127 -2 0.718
PLK2PLK2 0.806 0.123 -3 0.800
RIPK1RIPK1 0.806 -0.166 1 0.797
EPHA3EPHA3 0.806 -0.030 2 0.784
JAK1JAK1 0.806 -0.035 1 0.753
MLK4MLK4 0.806 -0.005 2 0.714
PTK2BPTK2B 0.806 0.044 -1 0.774
GSK3AGSK3A 0.805 0.117 4 0.512
EPHA5EPHA5 0.805 0.055 2 0.801
DNAPKDNAPK 0.805 0.043 1 0.695
PKN2PKN2 0.805 0.043 -3 0.793
TEKTEK 0.805 -0.090 3 0.739
PIM2PIM2 0.805 0.095 -3 0.727
CDC7CDC7 0.805 -0.019 1 0.792
BTKBTK 0.805 -0.089 -1 0.756
GRK2GRK2 0.804 -0.023 -2 0.718
ERK7ERK7 0.804 0.107 2 0.577
SRPK1SRPK1 0.804 0.165 -3 0.732
AXLAXL 0.804 -0.096 3 0.768
HASPINHASPIN 0.803 0.021 -1 0.701
TSSK2TSSK2 0.803 -0.052 -5 0.861
PDHK1PDHK1 0.803 -0.245 1 0.836
LTKLTK 0.803 -0.064 3 0.756
ATMATM 0.803 0.011 1 0.749
CAMK2BCAMK2B 0.803 0.133 2 0.832
MATKMATK 0.803 -0.044 -1 0.740
FGFR4FGFR4 0.802 0.017 -1 0.764
CDK14CDK14 0.802 0.135 1 0.743
WEE1_TYRWEE1_TYR 0.802 -0.075 -1 0.738
NTRK1NTRK1 0.802 -0.128 -1 0.799
ALKALK 0.802 -0.078 3 0.738
EPHA1EPHA1 0.802 -0.025 3 0.771
DDR2DDR2 0.802 0.012 3 0.753
TAO1TAO1 0.802 -0.113 1 0.722
CLK2CLK2 0.801 0.254 -3 0.760
DCAMKL2DCAMKL2 0.801 -0.000 -3 0.790
DYRK1ADYRK1A 0.801 0.111 1 0.795
CDK3CDK3 0.801 0.197 1 0.665
SRPK3SRPK3 0.801 0.108 -3 0.701
CHK1CHK1 0.801 -0.018 -3 0.796
DRAK1DRAK1 0.801 -0.041 1 0.746
AMPKA1AMPKA1 0.801 -0.043 -3 0.815
HUNKHUNK 0.801 -0.123 2 0.800
CAMK2DCAMK2D 0.800 0.028 -3 0.772
ERBB4ERBB4 0.800 0.089 1 0.748
IRAK4IRAK4 0.800 -0.119 1 0.787
TBK1TBK1 0.800 -0.063 1 0.743
INSRINSR 0.800 -0.102 3 0.712
TGFBR2TGFBR2 0.800 -0.017 -2 0.814
GSK3BGSK3B 0.800 0.041 4 0.501
P70S6KBP70S6KB 0.800 0.005 -3 0.770
RSK2RSK2 0.800 0.099 -3 0.753
TNK1TNK1 0.799 -0.123 3 0.759
MOKMOK 0.799 0.119 1 0.790
CSKCSK 0.799 -0.036 2 0.804
SLKSLK 0.799 -0.120 -2 0.671
TNNI3K_TYRTNNI3K_TYR 0.799 -0.073 1 0.809
PTK6PTK6 0.799 -0.173 -1 0.714
HIPK3HIPK3 0.799 0.095 1 0.778
HIPK4HIPK4 0.798 0.109 1 0.816
NTRK3NTRK3 0.798 -0.078 -1 0.759
CDK2CDK2 0.798 0.108 1 0.800
EPHA2EPHA2 0.798 0.066 -1 0.785
NEK2NEK2 0.798 -0.152 2 0.783
NEK10_TYRNEK10_TYR 0.798 -0.168 1 0.690
DYRK4DYRK4 0.798 0.171 1 0.697
NEK7NEK7 0.798 -0.129 -3 0.741
PDGFRAPDGFRA 0.798 -0.204 3 0.807
CLK1CLK1 0.797 0.165 -3 0.734
SGK3SGK3 0.797 0.042 -3 0.738
FLT4FLT4 0.797 -0.141 3 0.748
TSSK1TSSK1 0.796 -0.004 -3 0.832
MARK4MARK4 0.796 -0.033 4 0.808
P90RSKP90RSK 0.796 0.065 -3 0.754
DYRK1BDYRK1B 0.796 0.117 1 0.730
CDK18CDK18 0.796 0.159 1 0.700
NTRK2NTRK2 0.796 -0.164 3 0.764
MYLK4MYLK4 0.795 -0.011 -2 0.727
ROCK1ROCK1 0.795 -0.018 -3 0.738
CAMK2ACAMK2A 0.795 0.093 2 0.842
NEK6NEK6 0.795 -0.030 -2 0.878
MRCKAMRCKA 0.795 -0.008 -3 0.738
TTBK2TTBK2 0.795 -0.124 2 0.703
HIPK2HIPK2 0.795 0.169 1 0.682
CDK17CDK17 0.794 0.128 1 0.649
ULK2ULK2 0.794 -0.177 2 0.762
CDK16CDK16 0.794 0.150 1 0.674
PINK1PINK1 0.794 -0.178 1 0.851
AKT2AKT2 0.794 0.054 -3 0.685
IKKBIKKB 0.793 -0.037 -2 0.733
CRIKCRIK 0.793 0.013 -3 0.689
IKKEIKKE 0.793 -0.090 1 0.728
DYRK3DYRK3 0.792 0.095 1 0.772
GRK4GRK4 0.792 -0.070 -2 0.830
CDK8CDK8 0.792 0.110 1 0.747
IRE1IRE1 0.792 -0.070 1 0.779
CDK13CDK13 0.792 0.098 1 0.729
MRCKBMRCKB 0.792 -0.006 -3 0.720
WNK3WNK3 0.792 -0.232 1 0.810
CDK6CDK6 0.791 0.102 1 0.721
PAK1PAK1 0.791 -0.032 -2 0.743
SMG1SMG1 0.791 -0.095 1 0.770
PKCAPKCA 0.790 0.031 2 0.711
CHAK1CHAK1 0.790 -0.181 2 0.742
CDK12CDK12 0.789 0.101 1 0.703
FAM20CFAM20C 0.789 0.250 2 0.724
SGK1SGK1 0.789 0.053 -3 0.617
IGF1RIGF1R 0.789 -0.082 3 0.657
IKKAIKKA 0.788 0.023 -2 0.741
IRE2IRE2 0.788 -0.079 2 0.727
PKCZPKCZ 0.788 -0.029 2 0.757
AMPKA2AMPKA2 0.788 -0.041 -3 0.793
NEK3NEK3 0.788 -0.217 1 0.758
RSK4RSK4 0.788 0.086 -3 0.738
ZAP70ZAP70 0.788 0.075 -1 0.738
PKCHPKCH 0.788 -0.026 2 0.703
NDR1NDR1 0.788 -0.010 -3 0.805
CDK4CDK4 0.787 0.080 1 0.695
MAPKAPK3MAPKAPK3 0.787 -0.001 -3 0.739
BUB1BUB1 0.787 -0.046 -5 0.791
PAK2PAK2 0.787 -0.114 -2 0.723
CK1DCK1D 0.787 0.055 -3 0.507
PKCBPKCB 0.786 0.029 2 0.716
GCN2GCN2 0.786 -0.104 2 0.796
RSK3RSK3 0.786 0.046 -3 0.744
GRK3GRK3 0.785 0.003 -2 0.682
CHK2CHK2 0.785 0.013 -3 0.635
CAMK4CAMK4 0.785 -0.117 -3 0.785
PKCGPKCG 0.785 0.011 2 0.729
CDK7CDK7 0.784 0.075 1 0.748
MSK1MSK1 0.784 0.032 -3 0.719
CDK10CDK10 0.784 0.135 1 0.725
IRAK1IRAK1 0.784 -0.275 -1 0.726
NDR2NDR2 0.783 0.068 -3 0.813
MAPKAPK2MAPKAPK2 0.783 0.099 -3 0.716
PRKD1PRKD1 0.783 0.047 -3 0.762
MELKMELK 0.783 -0.070 -3 0.770
MUSKMUSK 0.783 -0.083 1 0.730
CAMK1DCAMK1D 0.782 -0.014 -3 0.685
PKACGPKACG 0.781 -0.020 -2 0.689
PLK4PLK4 0.781 -0.101 2 0.616
CAMK1GCAMK1G 0.781 -0.034 -3 0.727
SRPK2SRPK2 0.781 0.122 -3 0.664
PAK3PAK3 0.781 -0.100 -2 0.737
LATS2LATS2 0.781 0.012 -5 0.752
AKT1AKT1 0.780 0.026 -3 0.701
NIM1NIM1 0.780 -0.081 3 0.749
CK1A2CK1A2 0.780 0.042 -3 0.512
CDK19CDK19 0.780 0.116 1 0.714
CDK9CDK9 0.780 0.050 1 0.738
PKCEPKCE 0.779 0.027 2 0.714
AURAAURA 0.779 -0.011 -2 0.570
PRKD3PRKD3 0.779 -0.006 -3 0.714
MARK2MARK2 0.779 -0.058 4 0.709
FESFES 0.779 -0.054 -1 0.715
QIKQIK 0.778 -0.131 -3 0.773
AURBAURB 0.778 -0.030 -2 0.594
KISKIS 0.778 0.190 1 0.762
MNK1MNK1 0.778 -0.008 -2 0.752
MSK2MSK2 0.777 -0.019 -3 0.711
CK1ECK1E 0.776 0.047 -3 0.562
YANK3YANK3 0.776 -0.012 2 0.454
NUAK1NUAK1 0.776 0.003 -3 0.770
BCKDKBCKDK 0.776 -0.167 -1 0.767
PRKD2PRKD2 0.776 0.047 -3 0.743
ULK1ULK1 0.775 -0.241 -3 0.712
QSKQSK 0.775 -0.038 4 0.775
STK33STK33 0.775 -0.178 2 0.633
MNK2MNK2 0.775 -0.022 -2 0.750
PKACBPKACB 0.775 0.046 -2 0.622
MARK3MARK3 0.774 -0.035 4 0.738
SBKSBK 0.773 0.042 -3 0.577
CK2A2CK2A2 0.773 0.070 1 0.638
PKCIPKCI 0.773 -0.044 2 0.729
PKG2PKG2 0.773 -0.029 -2 0.610
MARK1MARK1 0.772 -0.093 4 0.756
PKCTPKCT 0.772 -0.043 2 0.704
RIPK2RIPK2 0.772 -0.330 1 0.724
AURCAURC 0.770 0.012 -2 0.596
SSTKSSTK 0.769 -0.121 4 0.771
PHKG1PHKG1 0.768 -0.049 -3 0.793
TTBK1TTBK1 0.766 -0.174 2 0.635
SIKSIK 0.765 -0.044 -3 0.736
P70S6KP70S6K 0.765 -0.044 -3 0.676
CK2A1CK2A1 0.765 0.054 1 0.612
YANK2YANK2 0.764 -0.039 2 0.469
CAMK1ACAMK1A 0.763 -0.031 -3 0.646
MAPKAPK5MAPKAPK5 0.763 -0.082 -3 0.666
AKT3AKT3 0.762 0.030 -3 0.628
PKACAPKACA 0.762 0.015 -2 0.559
PRKXPRKX 0.760 0.085 -3 0.707
PKN1PKN1 0.759 -0.009 -3 0.693
PAK6PAK6 0.758 -0.016 -2 0.640
BRSK1BRSK1 0.756 -0.071 -3 0.763
SNRKSNRK 0.756 -0.251 2 0.665
BRSK2BRSK2 0.753 -0.138 -3 0.772
PHKG2PHKG2 0.752 -0.045 -3 0.768
CK1G1CK1G1 0.747 0.001 -3 0.567
PAK5PAK5 0.739 -0.089 -2 0.582
CK1G3CK1G3 0.738 -0.001 -3 0.393
PAK4PAK4 0.731 -0.077 -2 0.588
CK1G2CK1G2 0.727 0.032 -3 0.482
PKG1PKG1 0.720 -0.095 -2 0.511
CK1ACK1A 0.717 0.005 -3 0.434