Motif 1193 (n=74)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PQS6 | RPS10-NUDT3 | Y12 | ochoa | Small ribosomal subunit protein eS10 (EC 3.6.1.52) (40S ribosomal protein S10) | Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000256|ARBA:ARBA00045797}. |
| A6NMY6 | ANXA2P2 | S12 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O00515 | LAD1 | S12 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O15020 | SPTBN2 | S12 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O43609 | SPRY1 | S12 | ochoa | Protein sprouty homolog 1 (Spry-1) | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}. |
| O60841 | EIF5B | S12 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O94768 | STK17B | S12 | ochoa|psp | Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) | Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}. |
| P07355 | ANXA2 | S12 | ochoa|psp | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P11245 | NAT2 | Y12 | psp | Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (N-hydroxyarylamine O-acetyltransferase) (EC 2.3.1.118) (Polymorphic arylamine N-acetyltransferase) (PNAT) | Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate several known carcinogens. {ECO:0000269|PubMed:12222688, ECO:0000269|PubMed:7915226}. |
| P12814 | ACTN1 | Y12 | ochoa|psp | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P29536 | LMOD1 | S12 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P33981 | TTK | T12 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35240 | NF2 | S12 | ochoa | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P38919 | EIF4A3 | S12 | ochoa | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P40938 | RFC3 | S12 | ochoa | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. {ECO:0000269|PubMed:9488738}. |
| P46783 | RPS10 | Y12 | ochoa | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P49207 | RPL34 | S12 | ochoa | Large ribosomal subunit protein eL34 (60S ribosomal protein L34) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P50443 | SLC26A2 | S12 | ochoa | Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}. |
| P53611 | RABGGTB | S12 | ochoa | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}. |
| P54252 | ATXN3 | S12 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P54709 | ATP1B3 | S12 | ochoa | Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298) | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. |
| P62277 | RPS13 | S12 | ochoa | Small ribosomal subunit protein uS15 (40S ribosomal protein S13) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P63313 | TMSB10 | S12 | ochoa | Thymosin beta-10 | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}. |
| P84098 | RPL19 | S12 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00536 | CDK16 | S12 | psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q03989 | ARID5A | S12 | ochoa | AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) | DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA (PubMed:32209697). Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250|UniProtKB:Q3U108, ECO:0000269|PubMed:15941852, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:8649988}. |
| Q07108 | CD69 | S12 | ochoa | Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69) | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481). {ECO:0000250|UniProtKB:P37217, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:26296369, ECO:0000269|PubMed:34841721, ECO:0000269|PubMed:35930205, ECO:0000269|PubMed:37039481}. |
| Q07869 | PPARA | S12 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q13286 | CLN3 | S12 | ochoa | Battenin (Batten disease protein) (Protein CLN3) | Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:15471887, PubMed:18317235, PubMed:18817525, PubMed:20850431, PubMed:22261744). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562). {ECO:0000250|UniProtKB:Q61124, ECO:0000269|PubMed:10924275, ECO:0000269|PubMed:15471887, ECO:0000269|PubMed:17482562, ECO:0000269|PubMed:18317235, ECO:0000269|PubMed:18817525, ECO:0000269|PubMed:20850431, ECO:0000269|PubMed:22261744, ECO:0000269|PubMed:23840424, ECO:0000269|PubMed:28390177}. |
| Q14149 | MORC3 | S12 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14511 | NEDD9 | Y12 | psp | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q15435 | PPP1R7 | S12 | ochoa | Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) | Regulatory subunit of protein phosphatase 1. {ECO:0000250}. |
| Q15699 | ALX1 | S12 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q16566 | CAMK4 | S12 | psp | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q53GI3 | ZNF394 | S12 | ochoa | Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14) | May be involved in transcriptional regulation. |
| Q5JSL3 | DOCK11 | S12 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q6ZV89 | SH2D5 | S12 | ochoa | SH2 domain-containing protein 5 | May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}. |
| Q7L1Q6 | BZW1 | S12 | ochoa | eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) | Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015). {ECO:0000269|PubMed:11524015, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| Q7L9L4 | MOB1B | T12 | psp | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7Z6J6 | FRMD5 | S12 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86TU7 | SETD3 | S12 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q8IY18 | SMC5 | S12 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8N3J5 | PPM1K | S12 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8NBF2 | NHLRC2 | S12 | ochoa | NHL repeat-containing protein 2 | Required for normal embryonic development. {ECO:0000250|UniProtKB:Q8BZW8}. |
| Q8NBU5 | ATAD1 | S12 | ochoa | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) | Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q9D5T0, ECO:0000269|PubMed:24843043}. |
| Q8NCA9 | ZNF784 | S12 | ochoa | Zinc finger protein 784 | May be involved in transcriptional regulation. |
| Q8NCN4 | RNF169 | S12 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8TC26 | TMEM163 | S12 | ochoa | Transmembrane protein 163 | Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}. |
| Q8TCG2 | PI4K2B | S12 | ochoa | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. |
| Q96A00 | PPP1R14A | S12 | psp | Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
| Q96EZ8 | MCRS1 | S12 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96FC7 | PHYHIPL | S12 | ochoa | Phytanoyl-CoA hydroxylase-interacting protein-like | May play a role in the development of the central system. {ECO:0000250}. |
| Q9BQF6 | SENP7 | S12 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BTA9 | WAC | S12 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9H0X9 | OSBPL5 | S12 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H492 | MAP1LC3A | S12 | psp | Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A) | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). {ECO:0000269|PubMed:20713600, ECO:0000269|PubMed:24290141, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. |
| Q9H8S9 | MOB1A | T12 | psp | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9NYL9 | TMOD3 | Y12 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NYN1 | RASL12 | S12 | ochoa | Ras-like protein family member 12 (EC 3.6.5.2) (Ras-like protein Ris) | None |
| Q9UBB4 | ATXN10 | S12 | ochoa|psp | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) | May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:P28658, ECO:0000250|UniProtKB:Q9ER24, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:25666058}. |
| Q9UBE0 | SAE1 | S12 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UBF2 | COPG2 | S12 | ochoa | Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| Q9UH99 | SUN2 | S12 | ochoa|psp | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UN42 | ATP1B4 | S12 | ochoa | Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m) | May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. {ECO:0000269|PubMed:17592128}. |
| Q9Y678 | COPG1 | S12 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| Q9Y6R1 | SLC4A4 | S12 | ochoa|psp | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| O60566 | BUB1B | S12 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9P287 | BCCIP | S12 | Sugiyama | BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333, ECO:0000269|PubMed:28394342}. |
| O43175 | PHGDH | S12 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O96013 | PAK4 | S12 | Sugiyama | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P68400 | CSNK2A1 | Y12 | Sugiyama | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q01085 | TIAL1 | Y12 | Sugiyama | Nucleolysin TIAR (TIA-1-related protein) | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:10613902, PubMed:1326761, PubMed:17488725, PubMed:8576255). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:1326761, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:8576255}. |
| P33552 | CKS2 | Y12 | Sugiyama | Cyclin-dependent kinases regulatory subunit 2 (CKS-2) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| P46109 | CRKL | S12 | Sugiyama | Crk-like protein | May mediate the transduction of intracellular signals. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.000042 | 4.373 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.000051 | 4.295 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.000051 | 4.295 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.000066 | 4.183 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.000066 | 4.183 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.000190 | 3.722 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.000199 | 3.702 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.000237 | 3.625 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.000248 | 3.606 |
| R-HSA-156902 | Peptide chain elongation | 0.000165 | 3.783 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.000248 | 3.606 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.000208 | 3.682 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.000170 | 3.771 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.000278 | 3.555 |
| R-HSA-192823 | Viral mRNA Translation | 0.000345 | 3.462 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.000318 | 3.497 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.000359 | 3.445 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.000419 | 3.378 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.000435 | 3.361 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.000744 | 3.129 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.001358 | 2.867 |
| R-HSA-5689877 | Josephin domain DUBs | 0.002174 | 2.663 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.002174 | 2.663 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.002188 | 2.660 |
| R-HSA-9711097 | Cellular response to starvation | 0.002355 | 2.628 |
| R-HSA-69091 | Polymerase switching | 0.003260 | 2.487 |
| R-HSA-69109 | Leading Strand Synthesis | 0.003260 | 2.487 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.003192 | 2.496 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.002719 | 2.566 |
| R-HSA-422475 | Axon guidance | 0.002798 | 2.553 |
| R-HSA-9675108 | Nervous system development | 0.004236 | 2.373 |
| R-HSA-168255 | Influenza Infection | 0.003884 | 2.411 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.004551 | 2.342 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.005026 | 2.299 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.004679 | 2.330 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.005522 | 2.258 |
| R-HSA-2028269 | Signaling by Hippo | 0.006040 | 2.219 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.006580 | 2.182 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.007140 | 2.146 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.008946 | 2.048 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.008324 | 2.080 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.009589 | 2.018 |
| R-HSA-72312 | rRNA processing | 0.010443 | 1.981 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.010934 | 1.961 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.011636 | 1.934 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.012357 | 1.908 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.012282 | 1.911 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.012600 | 1.900 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 0.015529 | 1.809 |
| R-HSA-3560792 | Defective SLC26A2 causes chondrodysplasias | 0.015529 | 1.809 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.014635 | 1.835 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.014635 | 1.835 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.013721 | 1.863 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.018302 | 1.738 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.017930 | 1.746 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.019684 | 1.706 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.018755 | 1.727 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.019684 | 1.706 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.019684 | 1.706 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.017930 | 1.746 |
| R-HSA-5205647 | Mitophagy | 0.019684 | 1.706 |
| R-HSA-69190 | DNA strand elongation | 0.017079 | 1.768 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.019684 | 1.706 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.019684 | 1.706 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.018798 | 1.726 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.020587 | 1.686 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.023397 | 1.631 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.023397 | 1.631 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.023634 | 1.626 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.026356 | 1.579 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.025354 | 1.596 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.025354 | 1.596 |
| R-HSA-72766 | Translation | 0.030477 | 1.516 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.027374 | 1.563 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.026356 | 1.579 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.032697 | 1.485 |
| R-HSA-9675135 | Diseases of DNA repair | 0.032697 | 1.485 |
| R-HSA-397014 | Muscle contraction | 0.033519 | 1.475 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.035864 | 1.445 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.035864 | 1.445 |
| R-HSA-73893 | DNA Damage Bypass | 0.036070 | 1.443 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.045875 | 1.338 |
| R-HSA-8875656 | MET receptor recycling | 0.055784 | 1.253 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.065591 | 1.183 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.080113 | 1.096 |
| R-HSA-72649 | Translation initiation complex formation | 0.041974 | 1.377 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.044430 | 1.352 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.044430 | 1.352 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.055784 | 1.253 |
| R-HSA-156582 | Acetylation | 0.080113 | 1.096 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.065591 | 1.183 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.055784 | 1.253 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.055784 | 1.253 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.046939 | 1.328 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.040766 | 1.390 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.046939 | 1.328 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.060700 | 1.217 |
| R-HSA-425381 | Bicarbonate transporters | 0.070456 | 1.152 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.075297 | 1.123 |
| R-HSA-428540 | Activation of RAC1 | 0.075297 | 1.123 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.080113 | 1.096 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.080113 | 1.096 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.070189 | 1.154 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.079131 | 1.102 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.040883 | 1.388 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.070456 | 1.152 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.070456 | 1.152 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.080113 | 1.096 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.080113 | 1.096 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.080113 | 1.096 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.055622 | 1.255 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.041974 | 1.377 |
| R-HSA-180786 | Extension of Telomeres | 0.048213 | 1.317 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.058839 | 1.230 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.068733 | 1.163 |
| R-HSA-9909396 | Circadian clock | 0.042703 | 1.370 |
| R-HSA-392499 | Metabolism of proteins | 0.075289 | 1.123 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.077617 | 1.110 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.079131 | 1.102 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.070456 | 1.152 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.061037 | 1.214 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.066616 | 1.176 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.056111 | 1.251 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.071655 | 1.145 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.049546 | 1.305 |
| R-HSA-1266738 | Developmental Biology | 0.084050 | 1.075 |
| R-HSA-170968 | Frs2-mediated activation | 0.084904 | 1.071 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.089984 | 1.046 |
| R-HSA-9663891 | Selective autophagy | 0.091569 | 1.038 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.094412 | 1.025 |
| R-HSA-174362 | Transport and metabolism of PAPS | 0.094412 | 1.025 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.094412 | 1.025 |
| R-HSA-73884 | Base Excision Repair | 0.094764 | 1.023 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.103822 | 0.984 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.126927 | 0.896 |
| R-HSA-429947 | Deadenylation of mRNA | 0.144987 | 0.839 |
| R-HSA-390522 | Striated Muscle Contraction | 0.188537 | 0.725 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.103822 | 0.984 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.107851 | 0.967 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.099129 | 1.004 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.158289 | 0.801 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.196980 | 0.706 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.180811 | 0.743 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.167043 | 0.777 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.117757 | 0.929 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.131477 | 0.881 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.184282 | 0.735 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.140634 | 0.852 |
| R-HSA-9843745 | Adipogenesis | 0.178946 | 0.747 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.184282 | 0.735 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.188537 | 0.725 |
| R-HSA-182971 | EGFR downregulation | 0.175707 | 0.755 |
| R-HSA-5693538 | Homology Directed Repair | 0.151394 | 0.820 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.103822 | 0.984 |
| R-HSA-169893 | Prolonged ERK activation events | 0.099129 | 1.004 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.177557 | 0.751 |
| R-HSA-8953854 | Metabolism of RNA | 0.159132 | 0.798 |
| R-HSA-977347 | Serine metabolism | 0.131477 | 0.881 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.149444 | 0.826 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.162677 | 0.789 |
| R-HSA-186763 | Downstream signal transduction | 0.175707 | 0.755 |
| R-HSA-69481 | G2/M Checkpoints | 0.169671 | 0.770 |
| R-HSA-157579 | Telomere Maintenance | 0.109520 | 0.961 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.109211 | 0.962 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.171386 | 0.766 |
| R-HSA-69239 | Synthesis of DNA | 0.128309 | 0.892 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.136004 | 0.866 |
| R-HSA-73886 | Chromosome Maintenance | 0.156835 | 0.805 |
| R-HSA-210991 | Basigin interactions | 0.126927 | 0.896 |
| R-HSA-187687 | Signalling to ERKs | 0.196980 | 0.706 |
| R-HSA-445144 | Signal transduction by L1 | 0.122354 | 0.912 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.153878 | 0.813 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.153878 | 0.813 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.192769 | 0.715 |
| R-HSA-114608 | Platelet degranulation | 0.169671 | 0.770 |
| R-HSA-5688426 | Deubiquitination | 0.173697 | 0.760 |
| R-HSA-373753 | Nephrin family interactions | 0.122354 | 0.912 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.149444 | 0.826 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.180006 | 0.745 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.182679 | 0.738 |
| R-HSA-3000170 | Syndecan interactions | 0.140507 | 0.852 |
| R-HSA-373760 | L1CAM interactions | 0.147788 | 0.830 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.149589 | 0.825 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.158289 | 0.801 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.196980 | 0.706 |
| R-HSA-190236 | Signaling by FGFR | 0.111196 | 0.954 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.126570 | 0.898 |
| R-HSA-1632852 | Macroautophagy | 0.199612 | 0.700 |
| R-HSA-111933 | Calmodulin induced events | 0.201169 | 0.696 |
| R-HSA-111997 | CaM pathway | 0.201169 | 0.696 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.201169 | 0.696 |
| R-HSA-446728 | Cell junction organization | 0.203874 | 0.691 |
| R-HSA-8875878 | MET promotes cell motility | 0.209482 | 0.679 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.213607 | 0.670 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.213607 | 0.670 |
| R-HSA-69242 | S Phase | 0.214819 | 0.668 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.221792 | 0.654 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.221792 | 0.654 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.221792 | 0.654 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.224379 | 0.649 |
| R-HSA-69306 | DNA Replication | 0.224379 | 0.649 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.225854 | 0.646 |
| R-HSA-1483257 | Phospholipid metabolism | 0.226921 | 0.644 |
| R-HSA-1989781 | PPARA activates gene expression | 0.228213 | 0.642 |
| R-HSA-111996 | Ca-dependent events | 0.229894 | 0.638 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.229894 | 0.638 |
| R-HSA-9612973 | Autophagy | 0.230132 | 0.638 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.232052 | 0.634 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.241890 | 0.616 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.241890 | 0.616 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.248406 | 0.605 |
| R-HSA-1483191 | Synthesis of PC | 0.249784 | 0.602 |
| R-HSA-5619102 | SLC transporter disorders | 0.251303 | 0.600 |
| R-HSA-1500931 | Cell-Cell communication | 0.256044 | 0.592 |
| R-HSA-597592 | Post-translational protein modification | 0.258211 | 0.588 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.262463 | 0.581 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.264811 | 0.577 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.264811 | 0.577 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.265330 | 0.576 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.268673 | 0.571 |
| R-HSA-72187 | mRNA 3'-end processing | 0.269167 | 0.570 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.269167 | 0.570 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.269167 | 0.570 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.272983 | 0.564 |
| R-HSA-1221632 | Meiotic synapsis | 0.272983 | 0.564 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.272983 | 0.564 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.280558 | 0.552 |
| R-HSA-9753281 | Paracetamol ADME | 0.280558 | 0.552 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.284316 | 0.546 |
| R-HSA-5578775 | Ion homeostasis | 0.284316 | 0.546 |
| R-HSA-177929 | Signaling by EGFR | 0.284316 | 0.546 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.284316 | 0.546 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.295473 | 0.529 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.295473 | 0.529 |
| R-HSA-2262752 | Cellular responses to stress | 0.298292 | 0.525 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.299154 | 0.524 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.302816 | 0.519 |
| R-HSA-112043 | PLC beta mediated events | 0.302816 | 0.519 |
| R-HSA-68877 | Mitotic Prometaphase | 0.303376 | 0.518 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.305299 | 0.515 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.306459 | 0.514 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.306459 | 0.514 |
| R-HSA-186797 | Signaling by PDGF | 0.306459 | 0.514 |
| R-HSA-9707616 | Heme signaling | 0.306459 | 0.514 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.306459 | 0.514 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.309140 | 0.510 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.310083 | 0.509 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.313689 | 0.504 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.316812 | 0.499 |
| R-HSA-73894 | DNA Repair | 0.318446 | 0.497 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.322554 | 0.491 |
| R-HSA-112040 | G-protein mediated events | 0.324394 | 0.489 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.324394 | 0.489 |
| R-HSA-72172 | mRNA Splicing | 0.326376 | 0.486 |
| R-HSA-1640170 | Cell Cycle | 0.331760 | 0.479 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.338411 | 0.471 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.338411 | 0.471 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.345312 | 0.462 |
| R-HSA-8852135 | Protein ubiquitination | 0.352141 | 0.453 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.352141 | 0.453 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.352141 | 0.453 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.352141 | 0.453 |
| R-HSA-418990 | Adherens junctions interactions | 0.352962 | 0.452 |
| R-HSA-5689603 | UCH proteinases | 0.355529 | 0.449 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.362253 | 0.441 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.365589 | 0.437 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.366899 | 0.435 |
| R-HSA-6806834 | Signaling by MET | 0.368908 | 0.433 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.371739 | 0.430 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.372670 | 0.429 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.375494 | 0.425 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.378762 | 0.422 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.382905 | 0.417 |
| R-HSA-1500620 | Meiosis | 0.385246 | 0.414 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.388463 | 0.411 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.388463 | 0.411 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.388463 | 0.411 |
| R-HSA-9824446 | Viral Infection Pathways | 0.391699 | 0.407 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.394848 | 0.404 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.394848 | 0.404 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.404947 | 0.393 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.406807 | 0.391 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.407419 | 0.390 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.407983 | 0.389 |
| R-HSA-4839726 | Chromatin organization | 0.410447 | 0.387 |
| R-HSA-109582 | Hemostasis | 0.410986 | 0.386 |
| R-HSA-391251 | Protein folding | 0.413608 | 0.383 |
| R-HSA-421270 | Cell-cell junction organization | 0.414076 | 0.383 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.422602 | 0.374 |
| R-HSA-162582 | Signal Transduction | 0.423188 | 0.373 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.428802 | 0.368 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.431794 | 0.365 |
| R-HSA-212436 | Generic Transcription Pathway | 0.437491 | 0.359 |
| R-HSA-3214847 | HATs acetylate histones | 0.437731 | 0.359 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.437731 | 0.359 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.440677 | 0.356 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.444469 | 0.352 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.446522 | 0.350 |
| R-HSA-1483255 | PI Metabolism | 0.446522 | 0.350 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.452307 | 0.345 |
| R-HSA-111885 | Opioid Signalling | 0.452307 | 0.345 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.454992 | 0.342 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.463675 | 0.334 |
| R-HSA-74160 | Gene expression (Transcription) | 0.467522 | 0.330 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.469306 | 0.329 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.483073 | 0.316 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.506970 | 0.295 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.512130 | 0.291 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.512130 | 0.291 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.527293 | 0.278 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.531742 | 0.274 |
| R-HSA-1474165 | Reproduction | 0.534699 | 0.272 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.536492 | 0.270 |
| R-HSA-5576891 | Cardiac conduction | 0.537142 | 0.270 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.553892 | 0.257 |
| R-HSA-6807070 | PTEN Regulation | 0.558567 | 0.253 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.563193 | 0.249 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.565816 | 0.247 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.576285 | 0.239 |
| R-HSA-166520 | Signaling by NTRKs | 0.581224 | 0.236 |
| R-HSA-9679506 | SARS-CoV Infections | 0.581950 | 0.235 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.585616 | 0.232 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.587795 | 0.231 |
| R-HSA-9609507 | Protein localization | 0.592118 | 0.228 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.594263 | 0.226 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.594263 | 0.226 |
| R-HSA-382551 | Transport of small molecules | 0.604976 | 0.218 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.606901 | 0.217 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.615109 | 0.211 |
| R-HSA-68886 | M Phase | 0.624542 | 0.204 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.632963 | 0.199 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.636818 | 0.196 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.638730 | 0.195 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.653676 | 0.185 |
| R-HSA-3781865 | Diseases of glycosylation | 0.655501 | 0.183 |
| R-HSA-449147 | Signaling by Interleukins | 0.659877 | 0.181 |
| R-HSA-983712 | Ion channel transport | 0.664483 | 0.178 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.671502 | 0.173 |
| R-HSA-5668914 | Diseases of metabolism | 0.681833 | 0.166 |
| R-HSA-199991 | Membrane Trafficking | 0.683129 | 0.165 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.683438 | 0.165 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.704478 | 0.152 |
| R-HSA-68882 | Mitotic Anaphase | 0.710669 | 0.148 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.712197 | 0.147 |
| R-HSA-9748784 | Drug ADME | 0.713717 | 0.146 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.725593 | 0.139 |
| R-HSA-112316 | Neuronal System | 0.727722 | 0.138 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.741131 | 0.130 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.743861 | 0.129 |
| R-HSA-1643685 | Disease | 0.747031 | 0.127 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.765948 | 0.116 |
| R-HSA-5663205 | Infectious disease | 0.802060 | 0.096 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.803588 | 0.095 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.809758 | 0.092 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.810767 | 0.091 |
| R-HSA-195721 | Signaling by WNT | 0.812770 | 0.090 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.813235 | 0.090 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.830890 | 0.080 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.836110 | 0.078 |
| R-HSA-8957322 | Metabolism of steroids | 0.836982 | 0.077 |
| R-HSA-1474244 | Extracellular matrix organization | 0.842953 | 0.074 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.855804 | 0.068 |
| R-HSA-913531 | Interferon Signaling | 0.881675 | 0.055 |
| R-HSA-418594 | G alpha (i) signalling events | 0.895945 | 0.048 |
| R-HSA-556833 | Metabolism of lipids | 0.904061 | 0.044 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.919577 | 0.036 |
| R-HSA-6798695 | Neutrophil degranulation | 0.920437 | 0.036 |
| R-HSA-211859 | Biological oxidations | 0.944244 | 0.025 |
| R-HSA-1430728 | Metabolism | 0.947802 | 0.023 |
| R-HSA-1280218 | Adaptive Immune System | 0.978041 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 0.985777 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.990992 | 0.004 |
| R-HSA-168256 | Immune System | 0.994148 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.994446 | 0.002 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.828 | 0.500 | -3 | 0.880 |
SRPK1 |
0.828 | 0.445 | -3 | 0.894 |
CLK3 |
0.826 | 0.344 | 1 | 0.757 |
AURC |
0.826 | 0.402 | -2 | 0.728 |
CLK1 |
0.826 | 0.488 | -3 | 0.873 |
CDKL5 |
0.825 | 0.436 | -3 | 0.892 |
CLK4 |
0.825 | 0.493 | -3 | 0.880 |
PRKD2 |
0.825 | 0.464 | -3 | 0.840 |
CDKL1 |
0.824 | 0.469 | -3 | 0.887 |
PIM1 |
0.824 | 0.485 | -3 | 0.868 |
SRPK2 |
0.822 | 0.453 | -3 | 0.864 |
P70S6KB |
0.821 | 0.468 | -3 | 0.863 |
RSK3 |
0.820 | 0.467 | -3 | 0.868 |
PIM3 |
0.820 | 0.407 | -3 | 0.854 |
P90RSK |
0.819 | 0.465 | -3 | 0.882 |
HIPK4 |
0.819 | 0.351 | 1 | 0.682 |
AKT2 |
0.819 | 0.516 | -3 | 0.859 |
CLK2 |
0.819 | 0.463 | -3 | 0.872 |
PKACB |
0.818 | 0.466 | -2 | 0.725 |
CAMK1B |
0.818 | 0.429 | -3 | 0.866 |
NDR1 |
0.817 | 0.386 | -3 | 0.836 |
AURB |
0.817 | 0.392 | -2 | 0.721 |
ICK |
0.816 | 0.405 | -3 | 0.886 |
PRKD1 |
0.816 | 0.354 | -3 | 0.841 |
PRKX |
0.815 | 0.474 | -3 | 0.804 |
PRKD3 |
0.814 | 0.452 | -3 | 0.862 |
PKACG |
0.814 | 0.404 | -2 | 0.743 |
NDR2 |
0.814 | 0.292 | -3 | 0.805 |
SRPK3 |
0.814 | 0.396 | -3 | 0.873 |
PKN3 |
0.813 | 0.354 | -3 | 0.844 |
MAPKAPK3 |
0.813 | 0.416 | -3 | 0.833 |
RSK4 |
0.813 | 0.464 | -3 | 0.856 |
PIM2 |
0.813 | 0.488 | -3 | 0.868 |
MSK1 |
0.812 | 0.465 | -3 | 0.861 |
CAMLCK |
0.812 | 0.433 | -2 | 0.831 |
SGK3 |
0.812 | 0.474 | -3 | 0.843 |
DAPK2 |
0.812 | 0.461 | -3 | 0.846 |
HIPK1 |
0.811 | 0.369 | 1 | 0.642 |
MYLK4 |
0.811 | 0.445 | -2 | 0.788 |
PKACA |
0.811 | 0.467 | -2 | 0.690 |
NLK |
0.811 | 0.206 | 1 | 0.760 |
CDC7 |
0.811 | 0.120 | 1 | 0.783 |
NUAK2 |
0.811 | 0.327 | -3 | 0.859 |
MSK2 |
0.811 | 0.446 | -3 | 0.868 |
AMPKA2 |
0.810 | 0.370 | -3 | 0.832 |
AKT1 |
0.810 | 0.502 | -3 | 0.851 |
AMPKA1 |
0.810 | 0.339 | -3 | 0.828 |
WNK1 |
0.810 | 0.268 | -2 | 0.809 |
MAPKAPK2 |
0.810 | 0.396 | -3 | 0.840 |
COT |
0.809 | 0.059 | 2 | 0.786 |
PAK6 |
0.809 | 0.335 | -2 | 0.738 |
PKG2 |
0.809 | 0.393 | -2 | 0.714 |
SKMLCK |
0.809 | 0.352 | -2 | 0.839 |
DYRK2 |
0.808 | 0.285 | 1 | 0.624 |
LATS2 |
0.807 | 0.251 | -5 | 0.719 |
AKT3 |
0.807 | 0.518 | -3 | 0.838 |
HIPK2 |
0.806 | 0.305 | 1 | 0.554 |
PKN2 |
0.806 | 0.307 | -3 | 0.837 |
PKCD |
0.806 | 0.296 | 2 | 0.677 |
MELK |
0.806 | 0.382 | -3 | 0.833 |
HIPK3 |
0.806 | 0.356 | 1 | 0.655 |
DYRK1A |
0.805 | 0.374 | 1 | 0.675 |
DYRK3 |
0.805 | 0.414 | 1 | 0.635 |
SGK1 |
0.804 | 0.520 | -3 | 0.827 |
NIK |
0.804 | 0.326 | -3 | 0.815 |
MOS |
0.804 | 0.090 | 1 | 0.804 |
MST4 |
0.803 | 0.175 | 2 | 0.771 |
RAF1 |
0.803 | 0.096 | 1 | 0.768 |
CAMK2D |
0.803 | 0.251 | -3 | 0.827 |
PAK1 |
0.803 | 0.330 | -2 | 0.794 |
MNK2 |
0.802 | 0.298 | -2 | 0.798 |
CAMK4 |
0.802 | 0.327 | -3 | 0.826 |
PRPK |
0.802 | -0.040 | -1 | 0.728 |
TSSK1 |
0.801 | 0.269 | -3 | 0.823 |
P70S6K |
0.801 | 0.438 | -3 | 0.848 |
PAK3 |
0.800 | 0.309 | -2 | 0.784 |
ERK5 |
0.800 | 0.096 | 1 | 0.768 |
AURA |
0.800 | 0.325 | -2 | 0.716 |
MAK |
0.800 | 0.393 | -2 | 0.716 |
CAMK1G |
0.799 | 0.382 | -3 | 0.867 |
TGFBR2 |
0.799 | 0.108 | -2 | 0.758 |
DYRK1B |
0.798 | 0.289 | 1 | 0.609 |
ATR |
0.798 | 0.059 | 1 | 0.734 |
MNK1 |
0.798 | 0.294 | -2 | 0.801 |
NUAK1 |
0.798 | 0.283 | -3 | 0.839 |
MRCKB |
0.797 | 0.499 | -3 | 0.846 |
MTOR |
0.797 | -0.033 | 1 | 0.737 |
RIPK3 |
0.797 | 0.108 | 3 | 0.735 |
CAMK1D |
0.797 | 0.448 | -3 | 0.818 |
PHKG1 |
0.797 | 0.267 | -3 | 0.830 |
TBK1 |
0.797 | 0.010 | 1 | 0.699 |
SMMLCK |
0.796 | 0.424 | -3 | 0.872 |
DCAMKL1 |
0.796 | 0.384 | -3 | 0.829 |
TSSK2 |
0.795 | 0.198 | -5 | 0.767 |
CAMK2A |
0.795 | 0.265 | 2 | 0.743 |
BMPR2 |
0.795 | -0.073 | -2 | 0.799 |
PAK2 |
0.795 | 0.311 | -2 | 0.775 |
MARK4 |
0.795 | 0.116 | 4 | 0.814 |
MOK |
0.795 | 0.414 | 1 | 0.665 |
PDHK4 |
0.794 | -0.143 | 1 | 0.776 |
DAPK3 |
0.794 | 0.457 | -3 | 0.861 |
CAMK2B |
0.794 | 0.230 | 2 | 0.747 |
BRSK1 |
0.794 | 0.285 | -3 | 0.837 |
DYRK4 |
0.794 | 0.248 | 1 | 0.572 |
WNK3 |
0.794 | 0.095 | 1 | 0.725 |
SIK |
0.794 | 0.296 | -3 | 0.827 |
CHK2 |
0.793 | 0.463 | -3 | 0.839 |
CAMK2G |
0.793 | -0.015 | 2 | 0.749 |
QSK |
0.793 | 0.227 | 4 | 0.802 |
LATS1 |
0.793 | 0.242 | -3 | 0.800 |
GCN2 |
0.792 | -0.084 | 2 | 0.695 |
CAMK1A |
0.792 | 0.455 | -3 | 0.835 |
PKCA |
0.792 | 0.207 | 2 | 0.613 |
DSTYK |
0.792 | -0.075 | 2 | 0.793 |
MAPKAPK5 |
0.792 | 0.339 | -3 | 0.842 |
CDK7 |
0.792 | 0.094 | 1 | 0.630 |
MRCKA |
0.792 | 0.482 | -3 | 0.842 |
NIM1 |
0.792 | 0.160 | 3 | 0.753 |
PKCB |
0.792 | 0.217 | 2 | 0.629 |
ROCK2 |
0.791 | 0.482 | -3 | 0.841 |
PKCG |
0.791 | 0.207 | 2 | 0.617 |
IKKB |
0.791 | -0.027 | -2 | 0.639 |
SBK |
0.791 | 0.476 | -3 | 0.810 |
DMPK1 |
0.790 | 0.500 | -3 | 0.862 |
IKKE |
0.790 | -0.029 | 1 | 0.689 |
CDK10 |
0.790 | 0.212 | 1 | 0.609 |
PKN1 |
0.790 | 0.394 | -3 | 0.858 |
PAK5 |
0.790 | 0.324 | -2 | 0.677 |
DAPK1 |
0.790 | 0.445 | -3 | 0.869 |
QIK |
0.789 | 0.186 | -3 | 0.814 |
BRSK2 |
0.789 | 0.206 | -3 | 0.821 |
ULK2 |
0.789 | -0.121 | 2 | 0.670 |
PDHK1 |
0.788 | -0.124 | 1 | 0.756 |
NEK6 |
0.788 | -0.059 | -2 | 0.770 |
PKCH |
0.787 | 0.219 | 2 | 0.598 |
DCAMKL2 |
0.787 | 0.280 | -3 | 0.844 |
PHKG2 |
0.787 | 0.274 | -3 | 0.837 |
PAK4 |
0.787 | 0.315 | -2 | 0.699 |
PKR |
0.787 | 0.117 | 1 | 0.738 |
HUNK |
0.787 | -0.041 | 2 | 0.685 |
JNK2 |
0.787 | 0.101 | 1 | 0.591 |
CDK14 |
0.786 | 0.177 | 1 | 0.618 |
BMPR1B |
0.786 | 0.093 | 1 | 0.712 |
RIPK1 |
0.786 | 0.067 | 1 | 0.725 |
PKCT |
0.786 | 0.280 | 2 | 0.617 |
PKCZ |
0.786 | 0.175 | 2 | 0.664 |
CHAK2 |
0.786 | -0.005 | -1 | 0.742 |
P38A |
0.785 | 0.096 | 1 | 0.670 |
ALK4 |
0.785 | 0.073 | -2 | 0.788 |
CRIK |
0.785 | 0.483 | -3 | 0.857 |
CHK1 |
0.784 | 0.193 | -3 | 0.764 |
PKCE |
0.783 | 0.315 | 2 | 0.599 |
DNAPK |
0.783 | 0.070 | 1 | 0.677 |
CDK18 |
0.783 | 0.088 | 1 | 0.575 |
KIS |
0.783 | 0.054 | 1 | 0.646 |
ANKRD3 |
0.783 | -0.020 | 1 | 0.770 |
NEK7 |
0.782 | -0.134 | -3 | 0.690 |
IRE1 |
0.782 | 0.024 | 1 | 0.686 |
ROCK1 |
0.782 | 0.469 | -3 | 0.842 |
MARK3 |
0.782 | 0.137 | 4 | 0.753 |
MASTL |
0.782 | -0.091 | -2 | 0.708 |
PKCI |
0.781 | 0.239 | 2 | 0.625 |
CDK8 |
0.781 | 0.026 | 1 | 0.597 |
ATM |
0.781 | 0.016 | 1 | 0.682 |
PKG1 |
0.781 | 0.382 | -2 | 0.653 |
NEK9 |
0.781 | -0.091 | 2 | 0.724 |
WNK4 |
0.781 | 0.170 | -2 | 0.787 |
TGFBR1 |
0.781 | 0.056 | -2 | 0.765 |
GRK6 |
0.781 | -0.023 | 1 | 0.739 |
MLK1 |
0.780 | -0.119 | 2 | 0.695 |
GRK5 |
0.780 | -0.145 | -3 | 0.722 |
BCKDK |
0.778 | -0.117 | -1 | 0.646 |
CDK19 |
0.778 | 0.037 | 1 | 0.570 |
NEK2 |
0.778 | -0.010 | 2 | 0.698 |
MARK1 |
0.778 | 0.133 | 4 | 0.777 |
SNRK |
0.778 | 0.129 | 2 | 0.568 |
GRK1 |
0.778 | -0.013 | -2 | 0.703 |
P38B |
0.777 | 0.069 | 1 | 0.613 |
IRE2 |
0.777 | 0.014 | 2 | 0.644 |
JNK3 |
0.777 | 0.054 | 1 | 0.621 |
ERK1 |
0.777 | 0.059 | 1 | 0.609 |
SMG1 |
0.777 | 0.052 | 1 | 0.689 |
DRAK1 |
0.777 | 0.089 | 1 | 0.723 |
MARK2 |
0.777 | 0.105 | 4 | 0.715 |
CDK5 |
0.777 | 0.054 | 1 | 0.643 |
MLK2 |
0.776 | -0.110 | 2 | 0.714 |
SSTK |
0.776 | 0.165 | 4 | 0.799 |
ALK2 |
0.775 | 0.058 | -2 | 0.764 |
ULK1 |
0.775 | -0.176 | -3 | 0.676 |
PLK1 |
0.775 | -0.030 | -2 | 0.730 |
BUB1 |
0.775 | 0.214 | -5 | 0.745 |
DLK |
0.775 | -0.115 | 1 | 0.712 |
TTBK2 |
0.775 | -0.111 | 2 | 0.588 |
MEK1 |
0.775 | -0.068 | 2 | 0.721 |
CDK17 |
0.774 | 0.056 | 1 | 0.524 |
MPSK1 |
0.774 | 0.107 | 1 | 0.708 |
ERK2 |
0.774 | 0.045 | 1 | 0.639 |
CDK13 |
0.773 | 0.024 | 1 | 0.614 |
FAM20C |
0.773 | 0.059 | 2 | 0.609 |
CDK9 |
0.773 | 0.048 | 1 | 0.625 |
VRK2 |
0.772 | -0.100 | 1 | 0.760 |
ACVR2A |
0.772 | -0.000 | -2 | 0.737 |
PERK |
0.772 | -0.020 | -2 | 0.752 |
IRAK4 |
0.772 | 0.058 | 1 | 0.704 |
MST3 |
0.771 | 0.084 | 2 | 0.727 |
P38G |
0.771 | 0.054 | 1 | 0.517 |
CDK12 |
0.771 | 0.048 | 1 | 0.590 |
PDK1 |
0.771 | 0.220 | 1 | 0.767 |
CDK16 |
0.771 | 0.083 | 1 | 0.542 |
ACVR2B |
0.770 | -0.005 | -2 | 0.741 |
PASK |
0.770 | 0.187 | -3 | 0.840 |
CDK1 |
0.770 | 0.027 | 1 | 0.589 |
HRI |
0.770 | -0.055 | -2 | 0.764 |
GAK |
0.770 | 0.154 | 1 | 0.798 |
GRK7 |
0.769 | -0.001 | 1 | 0.685 |
BRAF |
0.769 | -0.035 | -4 | 0.756 |
MLK3 |
0.768 | -0.084 | 2 | 0.629 |
YSK4 |
0.768 | -0.116 | 1 | 0.692 |
IKKA |
0.767 | -0.127 | -2 | 0.626 |
PRP4 |
0.767 | -0.010 | -3 | 0.628 |
CHAK1 |
0.767 | -0.067 | 2 | 0.644 |
CDK3 |
0.766 | 0.060 | 1 | 0.545 |
BMPR1A |
0.766 | 0.049 | 1 | 0.689 |
GRK4 |
0.765 | -0.177 | -2 | 0.735 |
PBK |
0.765 | 0.197 | 1 | 0.754 |
NEK5 |
0.765 | -0.033 | 1 | 0.744 |
MEK5 |
0.765 | -0.101 | 2 | 0.707 |
PLK3 |
0.764 | -0.083 | 2 | 0.680 |
PLK4 |
0.764 | -0.043 | 2 | 0.532 |
CDK4 |
0.763 | 0.104 | 1 | 0.573 |
CDK2 |
0.763 | -0.010 | 1 | 0.650 |
LKB1 |
0.762 | 0.005 | -3 | 0.683 |
TAO3 |
0.762 | -0.000 | 1 | 0.707 |
P38D |
0.762 | 0.045 | 1 | 0.549 |
HPK1 |
0.762 | 0.131 | 1 | 0.735 |
LOK |
0.762 | 0.133 | -2 | 0.686 |
ERK7 |
0.761 | 0.019 | 2 | 0.445 |
MEKK1 |
0.761 | -0.144 | 1 | 0.702 |
TAO2 |
0.761 | 0.021 | 2 | 0.744 |
NEK4 |
0.760 | 0.009 | 1 | 0.715 |
NEK8 |
0.760 | -0.009 | 2 | 0.697 |
TLK1 |
0.760 | -0.084 | -2 | 0.758 |
GRK2 |
0.760 | -0.079 | -2 | 0.637 |
PDHK3_TYR |
0.760 | 0.155 | 4 | 0.856 |
TNIK |
0.759 | 0.075 | 3 | 0.841 |
CK1E |
0.759 | -0.023 | -3 | 0.503 |
TLK2 |
0.759 | -0.125 | 1 | 0.660 |
MLK4 |
0.759 | -0.147 | 2 | 0.610 |
PINK1 |
0.759 | -0.136 | 1 | 0.730 |
NEK11 |
0.758 | -0.066 | 1 | 0.731 |
CAMKK2 |
0.758 | -0.047 | -2 | 0.652 |
GCK |
0.758 | 0.050 | 1 | 0.732 |
KHS2 |
0.758 | 0.142 | 1 | 0.735 |
CDK6 |
0.758 | 0.061 | 1 | 0.605 |
MEKK6 |
0.757 | 0.019 | 1 | 0.685 |
KHS1 |
0.756 | 0.115 | 1 | 0.724 |
LIMK2_TYR |
0.756 | 0.209 | -3 | 0.773 |
MEKK2 |
0.756 | -0.134 | 2 | 0.689 |
HASPIN |
0.756 | 0.118 | -1 | 0.626 |
NEK1 |
0.756 | 0.034 | 1 | 0.718 |
CK1D |
0.756 | -0.019 | -3 | 0.466 |
MEKK3 |
0.756 | -0.169 | 1 | 0.705 |
TTBK1 |
0.756 | -0.099 | 2 | 0.508 |
IRAK1 |
0.755 | -0.114 | -1 | 0.645 |
HGK |
0.755 | 0.015 | 3 | 0.826 |
TESK1_TYR |
0.754 | 0.094 | 3 | 0.859 |
ZAK |
0.754 | -0.173 | 1 | 0.663 |
CAMKK1 |
0.754 | -0.139 | -2 | 0.648 |
CK1A2 |
0.753 | -0.014 | -3 | 0.476 |
MINK |
0.753 | 0.002 | 1 | 0.720 |
BIKE |
0.753 | 0.165 | 1 | 0.726 |
LRRK2 |
0.753 | 0.016 | 2 | 0.733 |
MAP2K4_TYR |
0.753 | 0.088 | -1 | 0.732 |
JNK1 |
0.753 | 0.020 | 1 | 0.580 |
TAK1 |
0.752 | -0.000 | 1 | 0.722 |
MAP3K15 |
0.752 | -0.046 | 1 | 0.669 |
CK1G1 |
0.750 | -0.043 | -3 | 0.497 |
GSK3B |
0.749 | -0.029 | 4 | 0.366 |
PKMYT1_TYR |
0.749 | 0.027 | 3 | 0.834 |
SLK |
0.749 | 0.011 | -2 | 0.617 |
EEF2K |
0.747 | -0.057 | 3 | 0.790 |
VRK1 |
0.747 | -0.055 | 2 | 0.741 |
MAP2K7_TYR |
0.747 | -0.046 | 2 | 0.758 |
CK2A2 |
0.746 | 0.025 | 1 | 0.680 |
YSK1 |
0.746 | -0.008 | 2 | 0.699 |
MAP2K6_TYR |
0.745 | -0.039 | -1 | 0.713 |
PDHK4_TYR |
0.745 | -0.046 | 2 | 0.789 |
EPHA6 |
0.745 | 0.042 | -1 | 0.726 |
PINK1_TYR |
0.745 | 0.012 | 1 | 0.744 |
GSK3A |
0.745 | -0.026 | 4 | 0.372 |
MST2 |
0.745 | -0.134 | 1 | 0.727 |
NEK3 |
0.745 | -0.041 | 1 | 0.675 |
RET |
0.744 | 0.046 | 1 | 0.701 |
ABL2 |
0.744 | 0.083 | -1 | 0.713 |
MEK2 |
0.744 | -0.122 | 2 | 0.700 |
GRK3 |
0.744 | -0.083 | -2 | 0.603 |
LIMK1_TYR |
0.743 | -0.002 | 2 | 0.748 |
TNK2 |
0.743 | 0.127 | 3 | 0.757 |
AAK1 |
0.743 | 0.184 | 1 | 0.652 |
MST1R |
0.743 | 0.019 | 3 | 0.817 |
MST1 |
0.742 | -0.086 | 1 | 0.710 |
EPHB4 |
0.742 | 0.035 | -1 | 0.724 |
TYRO3 |
0.741 | 0.024 | 3 | 0.784 |
RIPK2 |
0.741 | -0.103 | 1 | 0.656 |
PDHK1_TYR |
0.741 | -0.106 | -1 | 0.728 |
DDR1 |
0.739 | 0.026 | 4 | 0.781 |
TXK |
0.739 | 0.089 | 1 | 0.745 |
TTK |
0.739 | 0.000 | -2 | 0.755 |
BMPR2_TYR |
0.739 | -0.103 | -1 | 0.704 |
STK33 |
0.739 | -0.091 | 2 | 0.489 |
ABL1 |
0.739 | 0.054 | -1 | 0.716 |
MYO3B |
0.737 | 0.019 | 2 | 0.720 |
TNK1 |
0.737 | 0.085 | 3 | 0.769 |
ROS1 |
0.737 | -0.023 | 3 | 0.759 |
NEK10_TYR |
0.736 | 0.051 | 1 | 0.624 |
CK2A1 |
0.736 | 0.012 | 1 | 0.660 |
TAO1 |
0.735 | 0.006 | 1 | 0.646 |
TYK2 |
0.735 | -0.117 | 1 | 0.705 |
YES1 |
0.734 | 0.016 | -1 | 0.746 |
LCK |
0.733 | 0.034 | -1 | 0.717 |
JAK2 |
0.733 | -0.108 | 1 | 0.701 |
BLK |
0.733 | 0.062 | -1 | 0.722 |
CSF1R |
0.733 | -0.077 | 3 | 0.793 |
AXL |
0.732 | 0.041 | 3 | 0.775 |
MERTK |
0.732 | 0.049 | 3 | 0.781 |
PLK2 |
0.731 | -0.121 | -3 | 0.609 |
TEC |
0.731 | 0.050 | -1 | 0.720 |
HCK |
0.730 | -0.021 | -1 | 0.722 |
INSRR |
0.730 | -0.053 | 3 | 0.738 |
EPHB3 |
0.730 | -0.017 | -1 | 0.712 |
FGR |
0.730 | -0.077 | 1 | 0.767 |
SRMS |
0.730 | -0.029 | 1 | 0.747 |
ASK1 |
0.730 | -0.094 | 1 | 0.659 |
EPHA1 |
0.730 | 0.067 | 3 | 0.775 |
JAK3 |
0.729 | -0.099 | 1 | 0.686 |
EPHA4 |
0.729 | -0.058 | 2 | 0.682 |
JAK1 |
0.729 | -0.020 | 1 | 0.670 |
LTK |
0.729 | 0.021 | 3 | 0.740 |
FER |
0.728 | -0.119 | 1 | 0.772 |
EPHB1 |
0.727 | -0.057 | 1 | 0.737 |
KDR |
0.727 | -0.035 | 3 | 0.764 |
EPHB2 |
0.727 | -0.040 | -1 | 0.706 |
FGFR2 |
0.726 | -0.086 | 3 | 0.784 |
YANK3 |
0.726 | -0.040 | 2 | 0.328 |
ITK |
0.726 | -0.044 | -1 | 0.706 |
MYO3A |
0.726 | -0.058 | 1 | 0.695 |
OSR1 |
0.726 | -0.127 | 2 | 0.683 |
BMX |
0.726 | -0.009 | -1 | 0.667 |
PTK2B |
0.725 | 0.042 | -1 | 0.727 |
TNNI3K_TYR |
0.725 | -0.046 | 1 | 0.681 |
TEK |
0.725 | -0.057 | 3 | 0.711 |
PDGFRB |
0.725 | -0.113 | 3 | 0.793 |
ALK |
0.724 | -0.035 | 3 | 0.711 |
FLT3 |
0.723 | -0.106 | 3 | 0.778 |
ALPHAK3 |
0.722 | -0.099 | -1 | 0.644 |
KIT |
0.722 | -0.131 | 3 | 0.783 |
WEE1_TYR |
0.722 | -0.055 | -1 | 0.662 |
DDR2 |
0.721 | 0.063 | 3 | 0.725 |
EPHA7 |
0.721 | -0.038 | 2 | 0.676 |
BTK |
0.721 | -0.067 | -1 | 0.710 |
FGFR1 |
0.721 | -0.127 | 3 | 0.761 |
PDGFRA |
0.720 | -0.120 | 3 | 0.792 |
FYN |
0.720 | -0.029 | -1 | 0.692 |
EPHA3 |
0.719 | -0.092 | 2 | 0.658 |
MET |
0.718 | -0.119 | 3 | 0.792 |
FRK |
0.716 | -0.064 | -1 | 0.750 |
PTK6 |
0.716 | -0.132 | -1 | 0.656 |
LYN |
0.715 | -0.074 | 3 | 0.697 |
EPHA5 |
0.714 | -0.059 | 2 | 0.673 |
NTRK1 |
0.713 | -0.180 | -1 | 0.676 |
FGFR3 |
0.712 | -0.133 | 3 | 0.762 |
FLT1 |
0.712 | -0.148 | -1 | 0.660 |
INSR |
0.711 | -0.144 | 3 | 0.717 |
NTRK2 |
0.710 | -0.175 | 3 | 0.752 |
FLT4 |
0.709 | -0.162 | 3 | 0.744 |
ERBB2 |
0.709 | -0.182 | 1 | 0.657 |
MATK |
0.708 | -0.130 | -1 | 0.636 |
EPHA8 |
0.707 | -0.110 | -1 | 0.681 |
SRC |
0.707 | -0.085 | -1 | 0.706 |
STLK3 |
0.706 | -0.220 | 1 | 0.631 |
CK1A |
0.705 | -0.081 | -3 | 0.389 |
NTRK3 |
0.705 | -0.168 | -1 | 0.635 |
CSK |
0.700 | -0.172 | 2 | 0.673 |
PTK2 |
0.700 | -0.087 | -1 | 0.616 |
EGFR |
0.699 | -0.152 | 1 | 0.562 |
EPHA2 |
0.698 | -0.111 | -1 | 0.645 |
MUSK |
0.698 | -0.131 | 1 | 0.565 |
FGFR4 |
0.697 | -0.155 | -1 | 0.646 |
CK1G3 |
0.696 | -0.060 | -3 | 0.351 |
SYK |
0.693 | -0.127 | -1 | 0.604 |
IGF1R |
0.693 | -0.166 | 3 | 0.648 |
FES |
0.688 | -0.126 | -1 | 0.644 |
ERBB4 |
0.687 | -0.136 | 1 | 0.585 |
YANK2 |
0.685 | -0.105 | 2 | 0.331 |
ZAP70 |
0.677 | -0.106 | -1 | 0.546 |
CK1G2 |
0.666 | -0.103 | -3 | 0.426 |