Motif 1190 (n=212)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PQS6 | RPS10-NUDT3 | Y12 | ochoa | Small ribosomal subunit protein eS10 (EC 3.6.1.52) (40S ribosomal protein S10) | Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000256|ARBA:ARBA00045797}. |
| A0A1W2PRX2 | None | Y13 | ochoa | Adenylosuccinate lyase | None |
| A6NKN8 | PCP4L1 | T12 | ochoa | Purkinje cell protein 4-like protein 1 (PCP4-like protein 1) | None |
| C9JAW5 | None | Y12 | ochoa | HIG1 domain-containing protein | None |
| K7ENP7 | None | T13 | ochoa | INO80 complex subunit C | None |
| O00148 | DDX39A | Y13 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O15211 | RGL2 | T12 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O43143 | DHX15 | Y13 | ochoa | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}. |
| O43707 | ACTN4 | Y13 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60437 | PPL | Y13 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60493 | SNX3 | T13 | ochoa | Sorting nexin-3 (Protein SDP3) | Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551). {ECO:0000250|UniProtKB:O70492, ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:18767904, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080, ECO:0000269|PubMed:24344282, ECO:0000305|PubMed:21725319}. |
| O60664 | PLIN3 | T12 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60841 | EIF5B | T13 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60927 | PPP1R11 | T13 | ochoa | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}. |
| O75179 | ANKRD17 | T12 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75907 | DGAT1 | T12 | ochoa | Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) | Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q8MK44, ECO:0000250|UniProtKB:Q9Z2A7, ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:18768481, ECO:0000269|PubMed:28420705, ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0000269|PubMed:9756920}. |
| O75909 | CCNK | T13 | ochoa | Cyclin-K | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}. |
| O95140 | MFN2 | T13 | ochoa | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:Q80U63, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:19889647, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26085578, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28114303, ECO:0000305}. |
| O95171 | SCEL | T12 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95562 | SFT2D2 | T13 | ochoa | Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) | May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}. |
| O95772 | STARD3NL | T13 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P05423 | POLR3D | T12 | ochoa | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}. |
| P05783 | KRT18 | Y13 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06241 | FYN | T12 | psp | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P06454 | PTMA | T13 | ochoa | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. |
| P0CG47 | UBB | T12 | ochoa|psp | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T12 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P11142 | HSPA8 | T13 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11245 | NAT2 | Y12 | psp | Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (N-hydroxyarylamine O-acetyltransferase) (EC 2.3.1.118) (Polymorphic arylamine N-acetyltransferase) (PNAT) | Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate several known carcinogens. {ECO:0000269|PubMed:12222688, ECO:0000269|PubMed:7915226}. |
| P12814 | ACTN1 | Y12 | ochoa|psp | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P14923 | JUP | T14 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15170 | GSPT1 | T13 | ochoa | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}. |
| P15923 | TCF3 | T12 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16885 | PLCG2 | Y13 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P16989 | YBX3 | T12 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P16989 | YBX3 | T13 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17980 | PSMC3 | T12 | ochoa | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P25098 | GRK2 | Y13 | psp | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}. |
| P30566 | ADSL | Y13 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P31350 | RRM2 | T12 | ochoa | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| P33981 | TTK | T12 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35580 | MYH10 | Y13 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35659 | DEK | T13 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P41743 | PRKCI | T13 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P43487 | RANBP1 | T13 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P46783 | RPS10 | Y12 | ochoa | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P49005 | POLD2 | T12 | ochoa | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| P50238 | CRIP1 | Y12 | ochoa | Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP) | Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. |
| P50402 | EMD | T13 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50748 | KNTC1 | T13 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P51580 | TPMT | Y13 | ochoa | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}. |
| P52926 | HMGA2 | T13 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| P52943 | CRIP2 | Y13 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P61956 | SUMO2 | T12 | ochoa | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}. |
| P62316 | SNRPD2 | T12 | ochoa | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}. |
| P62877 | RBX1 | T13 | ochoa | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:11961546, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:22748924, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:32355176, PubMed:33417871, PubMed:38326650, PubMed:39504960, PubMed:39667934, PubMed:38316879). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex mediates ubiquitination of Pol II subunit POLR2A at 'Lys-1268', a critical TC-NER checkpoint (PubMed:32355176, PubMed:34526721). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35982156). Core component of a Cul9-RING ubiquitin ligase complex composed of CUL9 and RBX1, which mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). {ECO:0000269|PubMed:10230407, ECO:0000269|PubMed:10579999, ECO:0000269|PubMed:11027288, ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:33417871, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:35982156, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:38605244, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| P62979 | RPS27A | T12 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T12 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P68400 | CSNK2A1 | T13 | psp | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| P68871 | HBB | T13 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P78358 | CTAG1A | T12 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
| Q00534 | CDK6 | Y13 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q01167 | FOXK2 | T13 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q03468 | ERCC6 | T12 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q05397 | PTK2 | T13 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06609 | RAD51 | T13 | ochoa|psp | DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:22325354, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:32640219). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:12205100, PubMed:18417535, PubMed:20231364, PubMed:20348101, PubMed:23509288, PubMed:23754376, PubMed:26681308, PubMed:28575658, PubMed:38459011). Recruited to resolve stalled replication forks during replication stress (PubMed:27797818, PubMed:31844045). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (PubMed:12442171, PubMed:24141787). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (PubMed:20413593). Also involved in interstrand cross-link repair (PubMed:26253028). {ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:38459011}. |
| Q13838 | DDX39B | Y13 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q15173 | PPP2R5B | T12 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}. |
| Q15361 | TTF1 | T12 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15822 | CHRNA2 | T12 | ochoa | Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2) | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:18723036). CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence (PubMed:24467848, PubMed:27493220). {ECO:0000269|PubMed:24467848, ECO:0000269|PubMed:27493220, ECO:0000303|PubMed:18723036}. |
| Q4VCS5 | AMOT | T12 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q4VCS5 | AMOT | T13 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5T0D9 | TPRG1L | T13 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q68D51 | DENND2C | T12 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6P1L5 | FAM117B | T12 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6PI98 | INO80C | T13 | ochoa | INO80 complex subunit C (IES6 homolog) (hIes6) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q6SPF0 | SAMD1 | T12 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q6TDP4 | KLHL17 | T12 | ochoa | Kelch-like protein 17 (Actinfilin) | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}. |
| Q75QN2 | INTS8 | T12 | ochoa | Integrator complex subunit 8 (Int8) (Protein kaonashi-1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:28542170, ECO:0000269|PubMed:32966759, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:38570683}. |
| Q7L8J4 | SH3BP5L | T13 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7L9L4 | MOB1B | T12 | psp | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q86YV0 | RASAL3 | T12 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8NFY9 | KBTBD8 | T13 | ochoa | Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}. |
| Q8WUM0 | NUP133 | T13 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVM7 | STAG1 | T13 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q92536 | SLC7A6 | T12 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
| Q92536 | SLC7A6 | Y13 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
| Q92600 | CNOT9 | T12 | ochoa | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}. |
| Q92600 | CNOT9 | T13 | ochoa | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}. |
| Q92619 | ARHGAP45 | T12 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q93015 | NAA80 | T13 | ochoa | N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) | N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307, ECO:0000269|PubMed:30028079}. |
| Q93052 | LPP | T12 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q93062 | RBPMS | T12 | ochoa | RNA-binding protein with multiple splicing (RBP-MS) (RBPMS) (Heart and RRM expressed sequence) (Hermes) | [Isoform A]: RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS) (PubMed:24860013, PubMed:26347403). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets (By similarity). Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (By similarity). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (PubMed:24860013, PubMed:26347403). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (By similarity). {ECO:0000250|UniProtKB:A0A8I6G705, ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:26347403}.; FUNCTION: [Isoform C]: Acts as a regulator of pre-mRNA alternative splicing (AS) (By similarity). Binds mRNA (PubMed:17099224). Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform A / RBPMSA (By similarity). Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins (PubMed:17099224). {ECO:0000250|UniProtKB:A0A8I6G705, ECO:0000269|PubMed:17099224}. |
| Q96B01 | RAD51AP1 | Y13 | ochoa | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}. |
| Q96CG3 | TIFA | T12 | psp | TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein) | Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28222186, PubMed:28877472, PubMed:30111836). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (PubMed:30111836). {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226, ECO:0000269|PubMed:26068852, ECO:0000269|PubMed:28222186, ECO:0000269|PubMed:28877472, ECO:0000269|PubMed:30111836}. |
| Q96CP6 | GRAMD1A | T12 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96EC8 | YIPF6 | T13 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
| Q96HB5 | CCDC120 | T12 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96MF7 | NSMCE2 | T12 | ochoa | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785). {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:31400850}. |
| Q96P20 | NLRP3 | Y13 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96S97 | MYADM | T12 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q96S97 | MYADM | T13 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q99536 | VAT1 | T12 | ochoa | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| Q9BQ67 | GRWD1 | T13 | ochoa | Glutamate-rich WD repeat-containing protein 1 | Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}. |
| Q9BXS9 | SLC26A6 | T12 | ochoa | Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1) | Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Also mediates intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger also provides a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Also mediates the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. {ECO:0000250|UniProtKB:Q8CIW6, ECO:0000269|PubMed:20501439, ECO:0000269|PubMed:27681177}.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. {ECO:0000269|PubMed:15990874}. |
| Q9BZF1 | OSBPL8 | T13 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C004 | SPRY4 | T12 | ochoa | Protein sprouty homolog 4 (Spry-4) | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}. |
| Q9GZP8 | IMUP | T12 | ochoa | Immortalization up-regulated protein (Hepatocyte growth factor activator inhibitor type 2-related small protein) (H2RSP) (HAI-2-related small protein) | None |
| Q9GZZ1 | NAA50 | T12 | ochoa | N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit) | N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:21900231, PubMed:22311970, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (PubMed:16507339, PubMed:27484799, PubMed:29754825, PubMed:32042062). Does not influence the acetyltransferase activity of NAA10 (PubMed:16507339, PubMed:27484799). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (PubMed:32042062). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821). {ECO:0000269|PubMed:16507339, ECO:0000269|PubMed:17502424, ECO:0000269|PubMed:19744929, ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:22311970, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27484799, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| Q9H1E3 | NUCKS1 | Y13 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H4A3 | WNK1 | T12 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H8S9 | MOB1A | T12 | psp | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9NP80 | PNPLA8 | Y12 | ochoa | Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) | Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428, PubMed:17213206, PubMed:18171998, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former (PubMed:15695510). Also has a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428). However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates (PubMed:15908428). Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers (PubMed:15695510, PubMed:15908428). Can also hydrolyze lysophosphatidylcholine (PubMed:15695510). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:28442572). {ECO:0000250|UniProtKB:Q8K1N1, ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:10833412, ECO:0000269|PubMed:15695510, ECO:0000269|PubMed:15908428, ECO:0000269|PubMed:17213206, ECO:0000269|PubMed:18171998, ECO:0000269|PubMed:28442572}. |
| Q9NRY5 | FAM114A2 | T13 | ochoa | Protein FAM114A2 | None |
| Q9NW08 | POLR3B | T12 | ochoa | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558766). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218}. |
| Q9NYL9 | TMOD3 | Y12 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZC7 | WWOX | T12 | ochoa | WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1) | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {ECO:0000250, ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}. |
| Q9P2K5 | MYEF2 | T13 | ochoa | Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) | Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}. |
| Q9UEY8 | ADD3 | T12 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | T12 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UJV9 | DDX41 | T13 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9ULH0 | KIDINS220 | Y12 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9Y241 | HIGD1A | Y12 | ochoa | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9Y2V2 | CARHSP1 | T13 | ochoa | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y3Q8 | TSC22D4 | T13 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y5Q3 | MAFB | T13 | ochoa | Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) | Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). {ECO:0000250|UniProtKB:P54841, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:27181683}. |
| Q9Y6J0 | CABIN1 | T12 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P51946 | CCNH | T12 | Sugiyama | Cyclin-H (MO15-associated protein) (p34) (p37) | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}. |
| P18621 | RPL17 | T12 | Sugiyama | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P05388 | RPLP0 | Y13 | Sugiyama | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| P19784 | CSNK2A2 | Y13 | Sugiyama | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q8NHW5 | RPLP0P6 | Y13 | Sugiyama | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| Q15024 | EXOSC7 | Y13 | Sugiyama | Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Q96B26 | EXOSC8 | Y13 | Sugiyama | Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| O15234 | CASC3 | T13 | Sugiyama | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P40818 | USP8 | Y12 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P84103 | SRSF3 | Y13 | Sugiyama | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| Q96ST3 | SIN3A | Y13 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q9H0R8 | GABARAPL1 | Y13 | Sugiyama | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) | Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. |
| O43813 | LANCL1 | Y13 | Sugiyama | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}. |
| Q01085 | TIAL1 | Y12 | Sugiyama | Nucleolysin TIAR (TIA-1-related protein) | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:10613902, PubMed:1326761, PubMed:17488725, PubMed:8576255). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:1326761, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:8576255}. |
| O60563 | CCNT1 | Y13 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O94776 | MTA2 | Y13 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| P56381 | ATP5F1E | Y12 | Sugiyama | ATP synthase F(1) complex subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon) | Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (PubMed:20026007). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:20026007, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| Q5VTU8 | ATP5F1EP2 | Y12 | Sugiyama | ATP synthase subunit epsilon-like protein, mitochondrial (ATP synthase F1 subunit epsilon pseudogene 2) | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250|UniProtKB:P56381}. |
| Q13330 | MTA1 | Y13 | Sugiyama | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q9BTC8 | MTA3 | Y13 | Sugiyama | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q13882 | PTK6 | Y13 | GPS6|EPSD | Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. {ECO:0000269|PubMed:20554524}.; FUNCTION: [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
| P41238 | APOBEC1 | T13 | Sugiyama | C->U-editing enzyme APOBEC-1 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic subunit 1) (APO1) (APOBEC-1) (Apolipoprotein B mRNA-editing enzyme 1) (EC 3.5.4.36) (HEPR) (mRNA(cytosine(6666)) deaminase 1) | Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). {ECO:0000250|UniProtKB:P51908, ECO:0000269|PubMed:11727199, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:30844405}. |
| P30622 | CLIP1 | T13 | PSP | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| Q9Y2N7 | HIF3A | T12 | SIGNOR | Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7) | Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000269|PubMed:11573933, ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. {ECO:0000269|PubMed:11573933}.; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805). {ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:17998805, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395}.; FUNCTION: [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}. |
| A2RRP1 | NBAS | T14 | ochoa | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}. |
| O43482 | OIP5 | T14 | ochoa | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| O43768 | ENSA | T14 | ochoa | Alpha-endosulfine (ARPP-19e) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| O60306 | AQR | T14 | ochoa | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| O75582 | RPS6KA5 | T14 | ochoa | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75694 | NUP155 | T14 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O94804 | STK10 | T14 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94811 | TPPP | T14 | ochoa|psp | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
| O95295 | SNAPIN | T14 | ochoa | SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}. |
| P06454 | PTMA | T14 | ochoa | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. |
| P06493 | CDK1 | T14 | ochoa|psp | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P09234 | SNRPC | T14 | ochoa | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}. |
| P0CG47 | UBB | T14 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T14 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P11142 | HSPA8 | T14 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P16989 | YBX3 | T14 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P23588 | EIF4B | T14 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P24941 | CDK2 | T14 | ochoa|psp | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P25788 | PSMA3 | T14 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P28066 | PSMA5 | T14 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P46782 | RPS5 | T14 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P49006 | MARCKSL1 | T14 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P50402 | EMD | T14 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50851 | LRBA | T14 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P52272 | HNRNPM | T14 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P55072 | VCP | T14 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P62979 | RPS27A | T14 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T14 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P78563 | ADARB1 | T14 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| Q00526 | CDK3 | T14 | ochoa|psp | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}. |
| Q00535 | CDK5 | T14 | ochoa | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q03114, ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}. |
| Q01130 | SRSF2 | T14 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q01196 | RUNX1 | T14 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q13277 | STX3 | T14 | psp | Syntaxin-3 | Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}. |
| Q13761 | RUNX3 | T14 | ochoa|psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q15019 | SEPTIN2 | T14 | ochoa | Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}. |
| Q16254 | E2F4 | T14 | ochoa | Transcription factor E2F4 (E2F-4) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Q63ZY3 | KANK2 | T14 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q86TU7 | SETD3 | T14 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q8IWA5 | SLC44A2 | T14 | ochoa | Choline transporter-like protein 2 (Solute carrier family 44 member 2) | [Isoform 1]: Choline/H+ antiporter, mainly in mitochodria (PubMed:10677542, PubMed:20665236, PubMed:23651124, PubMed:33789160). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:33789160}.; FUNCTION: [Isoform 3]: Does not exhibit choline transporter activity. {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236}. |
| Q8IWJ2 | GCC2 | T14 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IZV2 | CMTM8 | T14 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8) | None |
| Q8WTQ4 | C16orf78 | T14 | ochoa | Uncharacterized protein C16orf78 | None |
| Q96FC7 | PHYHIPL | T14 | ochoa | Phytanoyl-CoA hydroxylase-interacting protein-like | May play a role in the development of the central system. {ECO:0000250}. |
| Q96LR5 | UBE2E2 | T14 | ochoa | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:9371400}. |
| Q96QD9 | FYTTD1 | T14 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q96S97 | MYADM | T14 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q99640 | PKMYT1 | T14 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99962 | SH3GL2 | T14 | psp | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}. |
| Q9H6S3 | EPS8L2 | T14 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H7Z6 | KAT8 | T14 | ochoa | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9H8V3 | ECT2 | T14 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NUV9 | GIMAP4 | T14 | ochoa | GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) | During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. {ECO:0000250, ECO:0000250|UniProtKB:Q99JY3}. |
| Q9ULW5 | RAB26 | T14 | ochoa | Ras-related protein Rab-26 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane (PubMed:23105096). Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (PubMed:20038531). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity). {ECO:0000250|UniProtKB:P51156, ECO:0000250|UniProtKB:P61006, ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}. |
| Q9Y342 | PLLP | T12 | ochoa | Plasmolipin (Plasma membrane proteolipid) | Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (PubMed:34999972). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000269|PubMed:26002055, ECO:0000269|PubMed:34999972}. |
| Q9Y5S1 | TRPV2 | T14 | ochoa | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}. |
| P63173 | RPL38 | T14 | Sugiyama | Large ribosomal subunit protein eL38 (60S ribosomal protein L38) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q15427 | SF3B4 | T14 | Sugiyama | Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}. |
| P68431 | H3C1 | T12 | GPS6|EPSD | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P84243 | H3-3A | T12 | SIGNOR | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| P61158 | ACTR3 | T14 | Sugiyama | Actin-related protein 3 (Actin-like protein 3) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69278 | Cell Cycle, Mitotic | 7.333911e-11 | 10.135 |
| R-HSA-1234174 | Cellular response to hypoxia | 8.477562e-10 | 9.072 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.415703e-09 | 8.617 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.295882e-09 | 8.639 |
| R-HSA-1640170 | Cell Cycle | 9.951990e-10 | 9.002 |
| R-HSA-69206 | G1/S Transition | 2.137794e-09 | 8.670 |
| R-HSA-8953854 | Metabolism of RNA | 1.291602e-09 | 8.889 |
| R-HSA-2262752 | Cellular responses to stress | 2.036858e-09 | 8.691 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.824161e-09 | 8.739 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.789584e-09 | 8.421 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.183580e-09 | 8.087 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.078454e-08 | 7.967 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.851213e-08 | 7.733 |
| R-HSA-1500931 | Cell-Cell communication | 1.726870e-08 | 7.763 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.040182e-08 | 7.690 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.630370e-08 | 7.580 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.037798e-08 | 7.394 |
| R-HSA-422475 | Axon guidance | 3.951396e-08 | 7.403 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.972734e-08 | 7.303 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.019378e-08 | 7.299 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.072683e-08 | 7.217 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 7.338822e-08 | 7.134 |
| R-HSA-69231 | Cyclin D associated events in G1 | 7.338822e-08 | 7.134 |
| R-HSA-69236 | G1 Phase | 7.338822e-08 | 7.134 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.334964e-08 | 7.030 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.120541e-07 | 6.951 |
| R-HSA-69242 | S Phase | 1.373257e-07 | 6.862 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.306921e-07 | 6.884 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.288186e-07 | 6.890 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.288186e-07 | 6.890 |
| R-HSA-9675108 | Nervous system development | 1.390823e-07 | 6.857 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.430085e-07 | 6.845 |
| R-HSA-9766229 | Degradation of CDH1 | 1.578480e-07 | 6.802 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.823780e-07 | 6.739 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.925904e-07 | 6.715 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.101571e-07 | 6.677 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.153846e-07 | 6.667 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.297124e-07 | 6.639 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.297124e-07 | 6.639 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.415423e-07 | 6.617 |
| R-HSA-74160 | Gene expression (Transcription) | 2.420164e-07 | 6.616 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.728068e-07 | 6.564 |
| R-HSA-4641258 | Degradation of DVL | 2.728068e-07 | 6.564 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.769216e-07 | 6.558 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.707827e-07 | 6.567 |
| R-HSA-68882 | Mitotic Anaphase | 3.202881e-07 | 6.494 |
| R-HSA-446728 | Cell junction organization | 3.081793e-07 | 6.511 |
| R-HSA-68886 | M Phase | 3.453644e-07 | 6.462 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.385181e-07 | 6.470 |
| R-HSA-418990 | Adherens junctions interactions | 3.576839e-07 | 6.447 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.800951e-07 | 6.420 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.114148e-07 | 6.386 |
| R-HSA-421270 | Cell-cell junction organization | 3.964021e-07 | 6.402 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.460784e-07 | 6.351 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.460784e-07 | 6.351 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.673460e-07 | 6.330 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.297516e-07 | 6.276 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.216240e-07 | 6.283 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 6.164415e-07 | 6.210 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 6.164415e-07 | 6.210 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.078497e-07 | 6.216 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.078497e-07 | 6.216 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 6.078497e-07 | 6.216 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 6.078497e-07 | 6.216 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.201463e-07 | 6.143 |
| R-HSA-9615710 | Late endosomal microautophagy | 8.227476e-07 | 6.085 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 8.173170e-07 | 6.088 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 8.572313e-07 | 6.067 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.047214e-07 | 6.043 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 9.622804e-07 | 6.017 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.085525e-06 | 5.964 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.085525e-06 | 5.964 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.085525e-06 | 5.964 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.096772e-06 | 5.960 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.185547e-06 | 5.926 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.245621e-06 | 5.905 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.389135e-06 | 5.857 |
| R-HSA-5689877 | Josephin domain DUBs | 1.389135e-06 | 5.857 |
| R-HSA-9663891 | Selective autophagy | 1.513001e-06 | 5.820 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.809764e-06 | 5.742 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.852025e-06 | 5.732 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.852025e-06 | 5.732 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.974729e-06 | 5.704 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.989389e-06 | 5.701 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.284142e-06 | 5.641 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.284142e-06 | 5.641 |
| R-HSA-5205647 | Mitophagy | 2.319724e-06 | 5.635 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.319724e-06 | 5.635 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.319724e-06 | 5.635 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.284142e-06 | 5.641 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.777084e-06 | 5.556 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.693243e-06 | 5.570 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.777084e-06 | 5.556 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.693243e-06 | 5.570 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.713670e-06 | 5.566 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.386499e-06 | 5.622 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.792382e-06 | 5.554 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.398244e-06 | 5.620 |
| R-HSA-169911 | Regulation of Apoptosis | 2.713670e-06 | 5.566 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.626551e-06 | 5.581 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.382732e-06 | 5.623 |
| R-HSA-6807070 | PTEN Regulation | 2.785485e-06 | 5.555 |
| R-HSA-162906 | HIV Infection | 2.866928e-06 | 5.543 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.033089e-06 | 5.518 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.037464e-06 | 5.517 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 3.498782e-06 | 5.456 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.395038e-06 | 5.469 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.418327e-06 | 5.466 |
| R-HSA-195721 | Signaling by WNT | 3.371604e-06 | 5.472 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.467036e-06 | 5.460 |
| R-HSA-4641257 | Degradation of AXIN | 3.670357e-06 | 5.435 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.670357e-06 | 5.435 |
| R-HSA-5689603 | UCH proteinases | 3.736132e-06 | 5.428 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 3.791293e-06 | 5.421 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 3.791293e-06 | 5.421 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.838953e-06 | 5.416 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.302660e-06 | 5.366 |
| R-HSA-69541 | Stabilization of p53 | 4.892999e-06 | 5.310 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.621107e-06 | 5.250 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.621107e-06 | 5.250 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 5.098228e-06 | 5.293 |
| R-HSA-9683683 | Maturation of protein E | 5.903502e-06 | 5.229 |
| R-HSA-9694493 | Maturation of protein E | 5.903502e-06 | 5.229 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.209995e-06 | 5.207 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.437139e-06 | 5.191 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.505592e-06 | 5.187 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 6.678262e-06 | 5.175 |
| R-HSA-69306 | DNA Replication | 6.979092e-06 | 5.156 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.398497e-06 | 5.131 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 8.652226e-06 | 5.063 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 8.652226e-06 | 5.063 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.693971e-06 | 5.114 |
| R-HSA-9612973 | Autophagy | 8.289541e-06 | 5.081 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 8.652226e-06 | 5.063 |
| R-HSA-193639 | p75NTR signals via NF-kB | 8.652226e-06 | 5.063 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.202527e-06 | 5.086 |
| R-HSA-69239 | Synthesis of DNA | 8.949336e-06 | 5.048 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 9.613339e-06 | 5.017 |
| R-HSA-9909396 | Circadian clock | 9.978067e-06 | 5.001 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.031945e-05 | 4.986 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.105529e-05 | 4.956 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.214183e-05 | 4.916 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.214183e-05 | 4.916 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.367671e-05 | 4.864 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.395014e-05 | 4.855 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.271291e-05 | 4.896 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.271291e-05 | 4.896 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.409956e-05 | 4.851 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.395014e-05 | 4.855 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.329172e-05 | 4.876 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.536871e-05 | 4.813 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.599226e-05 | 4.796 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.740438e-05 | 4.759 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.771917e-05 | 4.752 |
| R-HSA-1632852 | Macroautophagy | 1.813770e-05 | 4.741 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.862534e-05 | 4.730 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.896367e-05 | 4.722 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.896367e-05 | 4.722 |
| R-HSA-162582 | Signal Transduction | 1.914644e-05 | 4.718 |
| R-HSA-73893 | DNA Damage Bypass | 1.927397e-05 | 4.715 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.938749e-05 | 4.712 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 2.041773e-05 | 4.690 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 2.041773e-05 | 4.690 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 2.041773e-05 | 4.690 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.628647e-05 | 4.580 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.628647e-05 | 4.580 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.312189e-05 | 4.636 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.628647e-05 | 4.580 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.550064e-05 | 4.593 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.326232e-05 | 4.633 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.628647e-05 | 4.580 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.396421e-05 | 4.620 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.297424e-05 | 4.639 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.520427e-05 | 4.599 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 2.791437e-05 | 4.554 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 2.860189e-05 | 4.544 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.923143e-05 | 4.534 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.923143e-05 | 4.534 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.955719e-05 | 4.529 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.984283e-05 | 4.525 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.517534e-05 | 4.454 |
| R-HSA-5619084 | ABC transporter disorders | 3.517534e-05 | 4.454 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.552535e-05 | 4.449 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.800780e-05 | 4.420 |
| R-HSA-9664873 | Pexophagy | 3.896531e-05 | 4.409 |
| R-HSA-69481 | G2/M Checkpoints | 3.965857e-05 | 4.402 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.992577e-05 | 4.399 |
| R-HSA-69275 | G2/M Transition | 4.062057e-05 | 4.391 |
| R-HSA-5688426 | Deubiquitination | 4.229056e-05 | 4.374 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.312581e-05 | 4.365 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.578278e-05 | 4.339 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.824903e-05 | 4.317 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.454057e-05 | 4.351 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.578278e-05 | 4.339 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.824903e-05 | 4.317 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 5.183868e-05 | 4.285 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.286994e-05 | 4.277 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 5.429321e-05 | 4.265 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.501611e-05 | 4.260 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.822193e-05 | 4.235 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.833230e-05 | 4.234 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.004419e-05 | 4.222 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.051909e-05 | 4.218 |
| R-HSA-209560 | NF-kB is activated and signals survival | 6.756876e-05 | 4.170 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 6.939312e-05 | 4.159 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.006071e-05 | 4.155 |
| R-HSA-9824446 | Viral Infection Pathways | 7.439511e-05 | 4.128 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.603082e-05 | 4.119 |
| R-HSA-8848021 | Signaling by PTK6 | 7.603082e-05 | 4.119 |
| R-HSA-72766 | Translation | 7.916291e-05 | 4.101 |
| R-HSA-156902 | Peptide chain elongation | 8.082007e-05 | 4.092 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.138597e-05 | 4.089 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 8.651711e-05 | 4.063 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 8.651711e-05 | 4.063 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 8.651711e-05 | 4.063 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 8.651711e-05 | 4.063 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 8.651711e-05 | 4.063 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 8.662028e-05 | 4.062 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.667518e-05 | 4.062 |
| R-HSA-1266738 | Developmental Biology | 9.254377e-05 | 4.034 |
| R-HSA-72172 | mRNA Splicing | 9.335391e-05 | 4.030 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 9.950385e-05 | 4.002 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.011598e-04 | 3.995 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.052477e-04 | 3.978 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.064547e-04 | 3.973 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.166561e-04 | 3.933 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.090589e-04 | 3.962 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.339101e-04 | 3.873 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.355815e-04 | 3.868 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.138434e-04 | 3.944 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.355815e-04 | 3.868 |
| R-HSA-5693538 | Homology Directed Repair | 1.225927e-04 | 3.912 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.355815e-04 | 3.868 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.352302e-04 | 3.869 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.476708e-04 | 3.831 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.530528e-04 | 3.815 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.573095e-04 | 3.803 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.664839e-04 | 3.779 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.664839e-04 | 3.779 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.664839e-04 | 3.779 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.674605e-04 | 3.776 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.734793e-04 | 3.761 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.742198e-04 | 3.759 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.791454e-04 | 3.747 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.964964e-04 | 3.707 |
| R-HSA-182971 | EGFR downregulation | 1.975510e-04 | 3.704 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 1.975510e-04 | 3.704 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.011980e-04 | 3.696 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.011980e-04 | 3.696 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.021748e-04 | 3.694 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.021748e-04 | 3.694 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.021748e-04 | 3.694 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.136115e-04 | 3.670 |
| R-HSA-162587 | HIV Life Cycle | 2.151795e-04 | 3.667 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.161205e-04 | 3.665 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.303711e-04 | 3.638 |
| R-HSA-72187 | mRNA 3'-end processing | 2.303711e-04 | 3.638 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.303711e-04 | 3.638 |
| R-HSA-192823 | Viral mRNA Translation | 2.403270e-04 | 3.619 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.430725e-04 | 3.614 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.430725e-04 | 3.614 |
| R-HSA-4086400 | PCP/CE pathway | 2.438226e-04 | 3.613 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.459882e-04 | 3.609 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.546767e-04 | 3.594 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.192717e-04 | 3.496 |
| R-HSA-73894 | DNA Repair | 3.589532e-04 | 3.445 |
| R-HSA-212436 | Generic Transcription Pathway | 3.452194e-04 | 3.462 |
| R-HSA-6806834 | Signaling by MET | 2.797472e-04 | 3.553 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.414972e-04 | 3.467 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.518579e-04 | 3.454 |
| R-HSA-3229121 | Glycogen storage diseases | 2.896028e-04 | 3.538 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.421992e-04 | 3.466 |
| R-HSA-157118 | Signaling by NOTCH | 3.602581e-04 | 3.443 |
| R-HSA-202403 | TCR signaling | 3.760146e-04 | 3.425 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.913432e-04 | 3.407 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.924454e-04 | 3.406 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.057984e-04 | 3.392 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.087596e-04 | 3.389 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.340854e-04 | 3.362 |
| R-HSA-3322077 | Glycogen synthesis | 4.673531e-04 | 3.330 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.797745e-04 | 3.319 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.802451e-04 | 3.319 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.923694e-04 | 3.308 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.284895e-04 | 3.277 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 5.408046e-04 | 3.267 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 5.408046e-04 | 3.267 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 5.408046e-04 | 3.267 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 5.408046e-04 | 3.267 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 5.408046e-04 | 3.267 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 5.408046e-04 | 3.267 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 5.408046e-04 | 3.267 |
| R-HSA-168255 | Influenza Infection | 5.607478e-04 | 3.251 |
| R-HSA-202424 | Downstream TCR signaling | 5.608052e-04 | 3.251 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.786473e-04 | 3.238 |
| R-HSA-2559583 | Cellular Senescence | 5.826686e-04 | 3.235 |
| R-HSA-9646399 | Aggrephagy | 5.835781e-04 | 3.234 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.988719e-04 | 3.223 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 6.221084e-04 | 3.206 |
| R-HSA-175474 | Assembly Of The HIV Virion | 6.221084e-04 | 3.206 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 6.221084e-04 | 3.206 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 6.221084e-04 | 3.206 |
| R-HSA-9607240 | FLT3 Signaling | 6.410890e-04 | 3.193 |
| R-HSA-8951664 | Neddylation | 6.894450e-04 | 3.162 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 7.027430e-04 | 3.153 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 7.117201e-04 | 3.148 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.245791e-04 | 3.140 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.582908e-04 | 3.120 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 7.687262e-04 | 3.114 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.801615e-04 | 3.108 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.848995e-04 | 3.105 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.899047e-04 | 3.102 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 8.392275e-04 | 3.076 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.680447e-04 | 3.061 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 9.034003e-04 | 3.044 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 9.639956e-04 | 3.016 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.645048e-04 | 3.016 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.042575e-03 | 2.982 |
| R-HSA-109581 | Apoptosis | 1.125690e-03 | 2.949 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.162419e-03 | 2.935 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.162419e-03 | 2.935 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.162419e-03 | 2.935 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.170272e-03 | 2.932 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.314048e-03 | 2.881 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 1.610169e-03 | 2.793 |
| R-HSA-8852135 | Protein ubiquitination | 1.238206e-03 | 2.907 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.744086e-03 | 2.758 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.660592e-03 | 2.780 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.314048e-03 | 2.881 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.578457e-03 | 2.802 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.462995e-03 | 2.835 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.686569e-03 | 2.773 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.766714e-03 | 2.753 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.756788e-03 | 2.755 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 1.300455e-03 | 2.886 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 1.367979e-03 | 2.864 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.449553e-03 | 2.839 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.610169e-03 | 2.793 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.300455e-03 | 2.886 |
| R-HSA-977225 | Amyloid fiber formation | 1.756788e-03 | 2.755 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.201656e-03 | 2.920 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.686569e-03 | 2.773 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.660592e-03 | 2.780 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.238206e-03 | 2.907 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.367979e-03 | 2.864 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.594105e-03 | 2.797 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.659678e-03 | 2.780 |
| R-HSA-9679506 | SARS-CoV Infections | 1.430421e-03 | 2.845 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.610169e-03 | 2.793 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.849786e-03 | 2.733 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.849786e-03 | 2.733 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.869519e-03 | 2.728 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.967772e-03 | 2.706 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.967772e-03 | 2.706 |
| R-HSA-72649 | Translation initiation complex formation | 1.969116e-03 | 2.706 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.969116e-03 | 2.706 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.117296e-03 | 2.674 |
| R-HSA-1538133 | G0 and Early G1 | 2.165658e-03 | 2.664 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.165658e-03 | 2.664 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.180699e-03 | 2.661 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.256666e-03 | 2.647 |
| R-HSA-177929 | Signaling by EGFR | 2.256666e-03 | 2.647 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.376860e-03 | 2.624 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.376860e-03 | 2.624 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.376860e-03 | 2.624 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.413787e-03 | 2.617 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.573642e-03 | 2.589 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.601819e-03 | 2.585 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.625773e-03 | 2.581 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.840970e-03 | 2.547 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.840970e-03 | 2.547 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.840970e-03 | 2.547 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.840970e-03 | 2.547 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.840970e-03 | 2.547 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.921734e-03 | 2.534 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 2.921734e-03 | 2.534 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 2.921734e-03 | 2.534 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 2.921734e-03 | 2.534 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 2.921734e-03 | 2.534 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 2.921734e-03 | 2.534 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.958924e-03 | 2.529 |
| R-HSA-5663205 | Infectious disease | 3.085350e-03 | 2.511 |
| R-HSA-68875 | Mitotic Prophase | 3.101888e-03 | 2.508 |
| R-HSA-450294 | MAP kinase activation | 3.107977e-03 | 2.508 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.229806e-03 | 2.491 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.250368e-03 | 2.488 |
| R-HSA-72312 | rRNA processing | 3.271442e-03 | 2.485 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.302635e-03 | 2.481 |
| R-HSA-68877 | Mitotic Prometaphase | 3.354125e-03 | 2.474 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.363566e-03 | 2.473 |
| R-HSA-9711097 | Cellular response to starvation | 3.727048e-03 | 2.429 |
| R-HSA-2028269 | Signaling by Hippo | 3.858476e-03 | 2.414 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.946710e-03 | 2.404 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.948024e-03 | 2.404 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.264481e-03 | 2.370 |
| R-HSA-9648002 | RAS processing | 4.264481e-03 | 2.370 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.264481e-03 | 2.370 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 4.503616e-03 | 2.346 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.510127e-03 | 2.346 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.541496e-03 | 2.343 |
| R-HSA-8982491 | Glycogen metabolism | 4.597627e-03 | 2.337 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.659095e-03 | 2.332 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.714701e-03 | 2.327 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.714701e-03 | 2.327 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.714701e-03 | 2.327 |
| R-HSA-190236 | Signaling by FGFR | 4.714701e-03 | 2.327 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.875054e-03 | 2.312 |
| R-HSA-5357801 | Programmed Cell Death | 4.911402e-03 | 2.309 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.923692e-03 | 2.308 |
| R-HSA-448424 | Interleukin-17 signaling | 5.188094e-03 | 2.285 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.315548e-03 | 2.274 |
| R-HSA-373753 | Nephrin family interactions | 5.490941e-03 | 2.260 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.591550e-03 | 2.252 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 5.828431e-03 | 2.234 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.059331e-03 | 2.218 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.072114e-03 | 2.217 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.104849e-03 | 2.214 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.104849e-03 | 2.214 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.371287e-03 | 2.196 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.427730e-03 | 2.192 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.968466e-03 | 2.157 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.968466e-03 | 2.157 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.028720e-03 | 2.153 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.122519e-03 | 2.147 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.122519e-03 | 2.147 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 7.309163e-03 | 2.136 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.404445e-03 | 2.131 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 7.429027e-03 | 2.129 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 7.429027e-03 | 2.129 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 7.429027e-03 | 2.129 |
| R-HSA-1483191 | Synthesis of PC | 7.909209e-03 | 2.102 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.938112e-03 | 2.100 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.461262e-03 | 2.073 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 8.941248e-03 | 2.049 |
| R-HSA-8849473 | PTK6 Expression | 8.941248e-03 | 2.049 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 8.941248e-03 | 2.049 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 9.702160e-03 | 2.013 |
| R-HSA-912446 | Meiotic recombination | 1.003263e-02 | 1.999 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.013390e-02 | 1.994 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.027647e-02 | 1.988 |
| R-HSA-449147 | Signaling by Interleukins | 1.028235e-02 | 1.988 |
| R-HSA-1500620 | Meiosis | 1.057864e-02 | 1.976 |
| R-HSA-9958517 | SLC-mediated bile acid transport | 1.072022e-02 | 1.970 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.072267e-02 | 1.970 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.101034e-02 | 1.958 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.103656e-02 | 1.957 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.103656e-02 | 1.957 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.122025e-02 | 1.950 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.122025e-02 | 1.950 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.183950e-02 | 1.927 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.183950e-02 | 1.927 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.249484e-02 | 1.903 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.249484e-02 | 1.903 |
| R-HSA-9613354 | Lipophagy | 1.264170e-02 | 1.898 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.264170e-02 | 1.898 |
| R-HSA-75072 | mRNA Editing | 1.264170e-02 | 1.898 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.264170e-02 | 1.898 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.308217e-02 | 1.883 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.308217e-02 | 1.883 |
| R-HSA-75893 | TNF signaling | 1.316542e-02 | 1.881 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.316542e-02 | 1.881 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.385852e-02 | 1.858 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.385852e-02 | 1.858 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.457438e-02 | 1.836 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.470141e-02 | 1.833 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.470141e-02 | 1.833 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.531323e-02 | 1.815 |
| R-HSA-9033241 | Peroxisomal protein import | 1.531323e-02 | 1.815 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.531323e-02 | 1.815 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.689577e-02 | 1.772 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.808123e-02 | 1.743 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.009919e-02 | 1.697 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.099601e-02 | 1.678 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.166844e-02 | 1.664 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.190896e-02 | 1.659 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.207619e-02 | 1.656 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.768072e-02 | 1.558 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 4.123366e-02 | 1.385 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 4.123366e-02 | 1.385 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 4.123366e-02 | 1.385 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 4.123366e-02 | 1.385 |
| R-HSA-5578995 | Defective TPMT causes TPMT deficiency | 4.123366e-02 | 1.385 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.424004e-02 | 1.615 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.424004e-02 | 1.615 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.692978e-02 | 1.570 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 2.973391e-02 | 1.527 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.567069e-02 | 1.448 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 4.202187e-02 | 1.377 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 4.534429e-02 | 1.343 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.919435e-02 | 1.535 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.127700e-02 | 1.384 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.973391e-02 | 1.527 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.127700e-02 | 1.384 |
| R-HSA-9907900 | Proteasome assembly | 3.760352e-02 | 1.425 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 2.768072e-02 | 1.558 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 4.123366e-02 | 1.385 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 4.123366e-02 | 1.385 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.424004e-02 | 1.615 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 4.202187e-02 | 1.377 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.614451e-02 | 1.583 |
| R-HSA-3371556 | Cellular response to heat stress | 4.293538e-02 | 1.367 |
| R-HSA-844456 | The NLRP3 inflammasome | 4.534429e-02 | 1.343 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.919435e-02 | 1.535 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.395696e-02 | 1.469 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.709798e-02 | 1.567 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.760352e-02 | 1.425 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.709798e-02 | 1.567 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 2.919435e-02 | 1.535 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 2.919435e-02 | 1.535 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 4.534429e-02 | 1.343 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.644782e-02 | 1.438 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.764687e-02 | 1.558 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.567069e-02 | 1.448 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.973391e-02 | 1.527 |
| R-HSA-9945266 | Differentiation of T cells | 3.264875e-02 | 1.486 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 3.264875e-02 | 1.486 |
| R-HSA-168249 | Innate Immune System | 2.468763e-02 | 1.608 |
| R-HSA-8876725 | Protein methylation | 2.973391e-02 | 1.527 |
| R-HSA-73887 | Death Receptor Signaling | 3.567275e-02 | 1.448 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.264875e-02 | 1.486 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.895057e-02 | 1.538 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.973391e-02 | 1.527 |
| R-HSA-373760 | L1CAM interactions | 3.754906e-02 | 1.425 |
| R-HSA-5218859 | Regulated Necrosis | 2.303075e-02 | 1.638 |
| R-HSA-9833110 | RSV-host interactions | 2.476808e-02 | 1.606 |
| R-HSA-1643685 | Disease | 3.740570e-02 | 1.427 |
| R-HSA-9824272 | Somitogenesis | 3.941836e-02 | 1.404 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.764687e-02 | 1.558 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 3.855761e-02 | 1.414 |
| R-HSA-917937 | Iron uptake and transport | 3.041286e-02 | 1.517 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 2.817759e-02 | 1.550 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.275002e-02 | 1.485 |
| R-HSA-70268 | Pyruvate metabolism | 4.744050e-02 | 1.324 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 4.876018e-02 | 1.312 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.876018e-02 | 1.312 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.876018e-02 | 1.312 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.876018e-02 | 1.312 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.876018e-02 | 1.312 |
| R-HSA-445144 | Signal transduction by L1 | 4.876018e-02 | 1.312 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.333179e-02 | 1.273 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.333179e-02 | 1.273 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.355340e-02 | 1.271 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 5.459851e-02 | 1.263 |
| R-HSA-75102 | C6 deamination of adenosine | 5.459851e-02 | 1.263 |
| R-HSA-9675132 | Diseases of cellular response to stress | 5.459851e-02 | 1.263 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 5.459851e-02 | 1.263 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.548828e-02 | 1.256 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 5.585952e-02 | 1.253 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.585952e-02 | 1.253 |
| R-HSA-1474165 | Reproduction | 5.634673e-02 | 1.249 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.676288e-02 | 1.246 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.676288e-02 | 1.246 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.676288e-02 | 1.246 |
| R-HSA-6803529 | FGFR2 alternative splicing | 5.953674e-02 | 1.225 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 5.953674e-02 | 1.225 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 5.953674e-02 | 1.225 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.064832e-02 | 1.217 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.176685e-02 | 1.209 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.600440e-02 | 1.180 |
| R-HSA-429947 | Deadenylation of mRNA | 6.713118e-02 | 1.173 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 6.713118e-02 | 1.173 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 6.777787e-02 | 1.169 |
| R-HSA-191859 | snRNP Assembly | 6.927616e-02 | 1.159 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.927616e-02 | 1.159 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 7.104258e-02 | 1.148 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.171159e-02 | 1.144 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.171159e-02 | 1.144 |
| R-HSA-351202 | Metabolism of polyamines | 7.171159e-02 | 1.144 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.418509e-02 | 1.130 |
| R-HSA-983712 | Ion channel transport | 7.470178e-02 | 1.127 |
| R-HSA-1280218 | Adaptive Immune System | 7.484120e-02 | 1.126 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 7.502631e-02 | 1.125 |
| R-HSA-6798695 | Neutrophil degranulation | 7.605363e-02 | 1.119 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.620539e-02 | 1.118 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.669616e-02 | 1.115 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.669616e-02 | 1.115 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 7.907963e-02 | 1.102 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.907963e-02 | 1.102 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 7.907963e-02 | 1.102 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 7.907963e-02 | 1.102 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 7.907963e-02 | 1.102 |
| R-HSA-373755 | Semaphorin interactions | 7.924432e-02 | 1.101 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 8.077431e-02 | 1.093 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 8.077431e-02 | 1.093 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 8.077431e-02 | 1.093 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 8.077431e-02 | 1.093 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 8.077431e-02 | 1.093 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 8.077431e-02 | 1.093 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 8.077431e-02 | 1.093 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 8.077431e-02 | 1.093 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.202102e-02 | 1.086 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.202102e-02 | 1.086 |
| R-HSA-167287 | HIV elongation arrest and recovery | 8.319983e-02 | 1.080 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 8.319983e-02 | 1.080 |
| R-HSA-622312 | Inflammasomes | 8.319983e-02 | 1.080 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 8.319983e-02 | 1.080 |
| R-HSA-166520 | Signaling by NTRKs | 8.623124e-02 | 1.064 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 8.710637e-02 | 1.060 |
| R-HSA-392499 | Metabolism of proteins | 8.727607e-02 | 1.059 |
| R-HSA-5334118 | DNA methylation | 8.738429e-02 | 1.059 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 8.738429e-02 | 1.059 |
| R-HSA-211000 | Gene Silencing by RNA | 8.804940e-02 | 1.055 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.960235e-02 | 1.048 |
| R-HSA-199991 | Membrane Trafficking | 9.063299e-02 | 1.043 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.163043e-02 | 1.038 |
| R-HSA-2424491 | DAP12 signaling | 9.163043e-02 | 1.038 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 9.163043e-02 | 1.038 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 9.163043e-02 | 1.038 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.166110e-02 | 1.038 |
| R-HSA-167172 | Transcription of the HIV genome | 9.252393e-02 | 1.034 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 9.359035e-02 | 1.029 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 9.359035e-02 | 1.029 |
| R-HSA-8849472 | PTK6 Down-Regulation | 9.359035e-02 | 1.029 |
| R-HSA-68911 | G2 Phase | 9.359035e-02 | 1.029 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 9.359035e-02 | 1.029 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 9.359035e-02 | 1.029 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 9.359035e-02 | 1.029 |
| R-HSA-8866376 | Reelin signalling pathway | 9.359035e-02 | 1.029 |
| R-HSA-9609507 | Protein localization | 9.478575e-02 | 1.023 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.593574e-02 | 1.018 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.593574e-02 | 1.018 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.807756e-02 | 1.008 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.002978e-01 | 0.999 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.007262e-01 | 0.997 |
| R-HSA-109582 | Hemostasis | 1.037374e-01 | 0.984 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.047141e-01 | 0.980 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.047141e-01 | 0.980 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.047141e-01 | 0.980 |
| R-HSA-9930044 | Nuclear RNA decay | 1.047141e-01 | 0.980 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.047141e-01 | 0.980 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.047141e-01 | 0.980 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.062285e-01 | 0.974 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.062285e-01 | 0.974 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.062285e-01 | 0.974 |
| R-HSA-75094 | Formation of the Editosome | 1.062285e-01 | 0.974 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.062285e-01 | 0.974 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.062285e-01 | 0.974 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.062285e-01 | 0.974 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.091824e-01 | 0.962 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.091824e-01 | 0.962 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.091824e-01 | 0.962 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.095758e-01 | 0.960 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.096204e-01 | 0.960 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.137004e-01 | 0.944 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.137004e-01 | 0.944 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.137004e-01 | 0.944 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.137004e-01 | 0.944 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.137004e-01 | 0.944 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.137004e-01 | 0.944 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.137004e-01 | 0.944 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.182658e-01 | 0.927 |
| R-HSA-381042 | PERK regulates gene expression | 1.182658e-01 | 0.927 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.186912e-01 | 0.926 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.186912e-01 | 0.926 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.186912e-01 | 0.926 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.186912e-01 | 0.926 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.186912e-01 | 0.926 |
| R-HSA-199920 | CREB phosphorylation | 1.186912e-01 | 0.926 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.186912e-01 | 0.926 |
| R-HSA-164944 | Nef and signal transduction | 1.186912e-01 | 0.926 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.228765e-01 | 0.911 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.228765e-01 | 0.911 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.228765e-01 | 0.911 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.228765e-01 | 0.911 |
| R-HSA-3371511 | HSF1 activation | 1.228765e-01 | 0.911 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.228765e-01 | 0.911 |
| R-HSA-73886 | Chromosome Maintenance | 1.235936e-01 | 0.908 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.235936e-01 | 0.908 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.275304e-01 | 0.894 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.275304e-01 | 0.894 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.284128e-01 | 0.891 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.309808e-01 | 0.883 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.309808e-01 | 0.883 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.309808e-01 | 0.883 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.309808e-01 | 0.883 |
| R-HSA-72200 | mRNA Editing: C to U Conversion | 1.309808e-01 | 0.883 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.309808e-01 | 0.883 |
| R-HSA-447041 | CHL1 interactions | 1.309808e-01 | 0.883 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.322252e-01 | 0.879 |
| R-HSA-168256 | Immune System | 1.348856e-01 | 0.870 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.369591e-01 | 0.863 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.369591e-01 | 0.863 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.369591e-01 | 0.863 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.417300e-01 | 0.849 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.417300e-01 | 0.849 |
| R-HSA-167169 | HIV Transcription Elongation | 1.417300e-01 | 0.849 |
| R-HSA-3371568 | Attenuation phase | 1.417300e-01 | 0.849 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.417300e-01 | 0.849 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.430999e-01 | 0.844 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.430999e-01 | 0.844 |
| R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors | 1.430999e-01 | 0.844 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 1.430999e-01 | 0.844 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.430999e-01 | 0.844 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.430999e-01 | 0.844 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.430999e-01 | 0.844 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.433288e-01 | 0.844 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.465359e-01 | 0.834 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.465359e-01 | 0.834 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.465359e-01 | 0.834 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.465359e-01 | 0.834 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.465359e-01 | 0.834 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.495122e-01 | 0.825 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.501580e-01 | 0.823 |
| R-HSA-170984 | ARMS-mediated activation | 1.550507e-01 | 0.810 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.550507e-01 | 0.810 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.550507e-01 | 0.810 |
| R-HSA-8939211 | ESR-mediated signaling | 1.552787e-01 | 0.809 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.562456e-01 | 0.806 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.567840e-01 | 0.805 |
| R-HSA-1483257 | Phospholipid metabolism | 1.569972e-01 | 0.804 |
| R-HSA-9710421 | Defective pyroptosis | 1.611457e-01 | 0.793 |
| R-HSA-2172127 | DAP12 interactions | 1.660735e-01 | 0.780 |
| R-HSA-373752 | Netrin-1 signaling | 1.660735e-01 | 0.780 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.660735e-01 | 0.780 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.668355e-01 | 0.778 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.668355e-01 | 0.778 |
| R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 1.668355e-01 | 0.778 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.668355e-01 | 0.778 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.668355e-01 | 0.778 |
| R-HSA-382551 | Transport of small molecules | 1.704062e-01 | 0.769 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.710274e-01 | 0.767 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.760057e-01 | 0.754 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.760057e-01 | 0.754 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.760057e-01 | 0.754 |
| R-HSA-9675135 | Diseases of DNA repair | 1.760057e-01 | 0.754 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.777919e-01 | 0.750 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.784567e-01 | 0.748 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.784567e-01 | 0.748 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.784567e-01 | 0.748 |
| R-HSA-4839744 | Signaling by APC mutants | 1.784567e-01 | 0.748 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.784567e-01 | 0.748 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.784567e-01 | 0.748 |
| R-HSA-210990 | PECAM1 interactions | 1.784567e-01 | 0.748 |
| R-HSA-4839726 | Chromatin organization | 1.792918e-01 | 0.746 |
| R-HSA-437239 | Recycling pathway of L1 | 1.810068e-01 | 0.742 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.810068e-01 | 0.742 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.860290e-01 | 0.730 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 1.899086e-01 | 0.721 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.899165e-01 | 0.721 |
| R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors | 1.899165e-01 | 0.721 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.899165e-01 | 0.721 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.899165e-01 | 0.721 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.899165e-01 | 0.721 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.906263e-01 | 0.720 |
| R-HSA-597592 | Post-translational protein modification | 1.944105e-01 | 0.711 |
| R-HSA-157579 | Telomere Maintenance | 1.947021e-01 | 0.711 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.012074e-01 | 0.696 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.012171e-01 | 0.696 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.012171e-01 | 0.696 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.012171e-01 | 0.696 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.012171e-01 | 0.696 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.012171e-01 | 0.696 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.012171e-01 | 0.696 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.012171e-01 | 0.696 |
| R-HSA-4641265 | Repression of WNT target genes | 2.012171e-01 | 0.696 |
| R-HSA-156582 | Acetylation | 2.012171e-01 | 0.696 |
| R-HSA-69091 | Polymerase switching | 2.012171e-01 | 0.696 |
| R-HSA-69109 | Leading Strand Synthesis | 2.012171e-01 | 0.696 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.012171e-01 | 0.696 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.012171e-01 | 0.696 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.012171e-01 | 0.696 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.012171e-01 | 0.696 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.062992e-01 | 0.686 |
| R-HSA-9758941 | Gastrulation | 2.089047e-01 | 0.680 |
| R-HSA-913531 | Interferon Signaling | 2.097744e-01 | 0.678 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.118086e-01 | 0.674 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 2.123608e-01 | 0.673 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.123608e-01 | 0.673 |
| R-HSA-181431 | Acetylcholine binding and downstream events | 2.123608e-01 | 0.673 |
| R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors | 2.123608e-01 | 0.673 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.123608e-01 | 0.673 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.123608e-01 | 0.673 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.123608e-01 | 0.673 |
| R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 2.123608e-01 | 0.673 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.199011e-01 | 0.658 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.233497e-01 | 0.651 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.233497e-01 | 0.651 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.233497e-01 | 0.651 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.233497e-01 | 0.651 |
| R-HSA-1170546 | Prolactin receptor signaling | 2.233497e-01 | 0.651 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.233497e-01 | 0.651 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.233497e-01 | 0.651 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.235359e-01 | 0.651 |
| R-HSA-5621480 | Dectin-2 family | 2.319382e-01 | 0.635 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.341859e-01 | 0.630 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.341859e-01 | 0.630 |
| R-HSA-9857492 | Protein lipoylation | 2.341859e-01 | 0.630 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.341859e-01 | 0.630 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.341859e-01 | 0.630 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.341859e-01 | 0.630 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.341859e-01 | 0.630 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.341859e-01 | 0.630 |
| R-HSA-180786 | Extension of Telomeres | 2.422538e-01 | 0.616 |
| R-HSA-8979227 | Triglyceride metabolism | 2.422538e-01 | 0.616 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 2.422538e-01 | 0.616 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.448716e-01 | 0.611 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.448716e-01 | 0.611 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.448716e-01 | 0.611 |
| R-HSA-5635838 | Activation of SMO | 2.448716e-01 | 0.611 |
| R-HSA-169893 | Prolonged ERK activation events | 2.448716e-01 | 0.611 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.448716e-01 | 0.611 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.448716e-01 | 0.611 |
| R-HSA-9678110 | Attachment and Entry | 2.448716e-01 | 0.611 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.460222e-01 | 0.609 |
| R-HSA-9658195 | Leishmania infection | 2.496447e-01 | 0.603 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.496447e-01 | 0.603 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.525892e-01 | 0.598 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.531814e-01 | 0.597 |
| R-HSA-6783984 | Glycine degradation | 2.554089e-01 | 0.593 |
| R-HSA-9927020 | Heme assimilation | 2.554089e-01 | 0.593 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.554089e-01 | 0.593 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.577615e-01 | 0.589 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.606789e-01 | 0.584 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.657997e-01 | 0.575 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.657997e-01 | 0.575 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.657997e-01 | 0.575 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.657997e-01 | 0.575 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.719779e-01 | 0.565 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.732841e-01 | 0.563 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.760462e-01 | 0.559 |
| R-HSA-3928664 | Ephrin signaling | 2.760462e-01 | 0.559 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.760462e-01 | 0.559 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.760462e-01 | 0.559 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.760462e-01 | 0.559 |
| R-HSA-5358508 | Mismatch Repair | 2.760462e-01 | 0.559 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 2.760462e-01 | 0.559 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 2.836270e-01 | 0.547 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.861503e-01 | 0.543 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.861503e-01 | 0.543 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.861503e-01 | 0.543 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.861503e-01 | 0.543 |
| R-HSA-9834899 | Specification of the neural plate border | 2.861503e-01 | 0.543 |
| R-HSA-449836 | Other interleukin signaling | 2.861503e-01 | 0.543 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.874324e-01 | 0.541 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.961141e-01 | 0.529 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.961141e-01 | 0.529 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.961141e-01 | 0.529 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.961141e-01 | 0.529 |
| R-HSA-196108 | Pregnenolone biosynthesis | 2.961141e-01 | 0.529 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.059393e-01 | 0.514 |
| R-HSA-198753 | ERK/MAPK targets | 3.059393e-01 | 0.514 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.059393e-01 | 0.514 |
| R-HSA-210991 | Basigin interactions | 3.059393e-01 | 0.514 |
| R-HSA-6809371 | Formation of the cornified envelope | 3.061427e-01 | 0.514 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.094109e-01 | 0.509 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.094109e-01 | 0.509 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.137675e-01 | 0.503 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.137675e-01 | 0.503 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.137675e-01 | 0.503 |
| R-HSA-194138 | Signaling by VEGF | 3.137675e-01 | 0.503 |
| R-HSA-9694614 | Attachment and Entry | 3.156280e-01 | 0.501 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.251820e-01 | 0.488 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.251820e-01 | 0.488 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 3.251820e-01 | 0.488 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.251820e-01 | 0.488 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.251820e-01 | 0.488 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.251820e-01 | 0.488 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.299065e-01 | 0.482 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.346033e-01 | 0.475 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.346033e-01 | 0.475 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.346033e-01 | 0.475 |
| R-HSA-3000170 | Syndecan interactions | 3.346033e-01 | 0.475 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.346033e-01 | 0.475 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 3.400937e-01 | 0.468 |
| R-HSA-9843745 | Adipogenesis | 3.404722e-01 | 0.468 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.438936e-01 | 0.464 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.438936e-01 | 0.464 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.438936e-01 | 0.464 |
| R-HSA-9833482 | PKR-mediated signaling | 3.502329e-01 | 0.456 |
| R-HSA-3214842 | HDMs demethylate histones | 3.530547e-01 | 0.452 |
| R-HSA-420029 | Tight junction interactions | 3.530547e-01 | 0.452 |
| R-HSA-9839394 | TGFBR3 expression | 3.530547e-01 | 0.452 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.530547e-01 | 0.452 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.530547e-01 | 0.452 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.530547e-01 | 0.452 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.530547e-01 | 0.452 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.620885e-01 | 0.441 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.620885e-01 | 0.441 |
| R-HSA-525793 | Myogenesis | 3.620885e-01 | 0.441 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.620885e-01 | 0.441 |
| R-HSA-3295583 | TRP channels | 3.620885e-01 | 0.441 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.620885e-01 | 0.441 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.709967e-01 | 0.431 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.709967e-01 | 0.431 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.709967e-01 | 0.431 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.709967e-01 | 0.431 |
| R-HSA-8949613 | Cristae formation | 3.709967e-01 | 0.431 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.709967e-01 | 0.431 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.709967e-01 | 0.431 |
| R-HSA-75109 | Triglyceride biosynthesis | 3.709967e-01 | 0.431 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.784744e-01 | 0.422 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.784744e-01 | 0.422 |
| R-HSA-9664407 | Parasite infection | 3.784744e-01 | 0.422 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.797810e-01 | 0.420 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.797810e-01 | 0.420 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.797810e-01 | 0.420 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.852717e-01 | 0.414 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.884432e-01 | 0.411 |
| R-HSA-72086 | mRNA Capping | 3.884432e-01 | 0.411 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.884432e-01 | 0.411 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.884432e-01 | 0.411 |
| R-HSA-180024 | DARPP-32 events | 3.884432e-01 | 0.411 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.902128e-01 | 0.409 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.902128e-01 | 0.409 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.960222e-01 | 0.402 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.969849e-01 | 0.401 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.969849e-01 | 0.401 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.049284e-01 | 0.393 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.134759e-01 | 0.384 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.137137e-01 | 0.383 |
| R-HSA-69190 | DNA strand elongation | 4.137137e-01 | 0.383 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.137137e-01 | 0.383 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.146445e-01 | 0.382 |
| R-HSA-391251 | Protein folding | 4.194731e-01 | 0.377 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.219040e-01 | 0.375 |
| R-HSA-354192 | Integrin signaling | 4.219040e-01 | 0.375 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.219040e-01 | 0.375 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.219040e-01 | 0.375 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.219040e-01 | 0.375 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.219040e-01 | 0.375 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.242814e-01 | 0.372 |
| R-HSA-390522 | Striated Muscle Contraction | 4.299804e-01 | 0.367 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.299804e-01 | 0.367 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.299804e-01 | 0.367 |
| R-HSA-5673000 | RAF activation | 4.379444e-01 | 0.359 |
| R-HSA-9610379 | HCMV Late Events | 4.455122e-01 | 0.351 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.457977e-01 | 0.351 |
| R-HSA-187687 | Signalling to ERKs | 4.457977e-01 | 0.351 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.457977e-01 | 0.351 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.457977e-01 | 0.351 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.503692e-01 | 0.346 |
| R-HSA-111933 | Calmodulin induced events | 4.535417e-01 | 0.343 |
| R-HSA-111997 | CaM pathway | 4.535417e-01 | 0.343 |
| R-HSA-163560 | Triglyceride catabolism | 4.535417e-01 | 0.343 |
| R-HSA-3214847 | HATs acetylate histones | 4.573440e-01 | 0.340 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 4.611779e-01 | 0.336 |
| R-HSA-70171 | Glycolysis | 4.619782e-01 | 0.335 |
| R-HSA-8875878 | MET promotes cell motility | 4.687080e-01 | 0.329 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.687080e-01 | 0.329 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.687080e-01 | 0.329 |
| R-HSA-201556 | Signaling by ALK | 4.761332e-01 | 0.322 |
| R-HSA-111885 | Opioid Signalling | 4.802818e-01 | 0.319 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.834551e-01 | 0.316 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.834551e-01 | 0.316 |
| R-HSA-5260271 | Diseases of Immune System | 4.834551e-01 | 0.316 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.834551e-01 | 0.316 |
| R-HSA-202433 | Generation of second messenger molecules | 4.834551e-01 | 0.316 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.834551e-01 | 0.316 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.906752e-01 | 0.309 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.906752e-01 | 0.309 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.906752e-01 | 0.309 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.977947e-01 | 0.303 |
| R-HSA-167161 | HIV Transcription Initiation | 4.977947e-01 | 0.303 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.977947e-01 | 0.303 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.977947e-01 | 0.303 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.977947e-01 | 0.303 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.026184e-01 | 0.299 |
| R-HSA-111996 | Ca-dependent events | 5.048152e-01 | 0.297 |
| R-HSA-165159 | MTOR signalling | 5.048152e-01 | 0.297 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 5.117380e-01 | 0.291 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.117380e-01 | 0.291 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.180677e-01 | 0.286 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.185644e-01 | 0.285 |
| R-HSA-5683826 | Surfactant metabolism | 5.185644e-01 | 0.285 |
| R-HSA-156581 | Methylation | 5.185644e-01 | 0.285 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 5.252958e-01 | 0.280 |
| R-HSA-774815 | Nucleosome assembly | 5.252958e-01 | 0.280 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.252958e-01 | 0.280 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.252958e-01 | 0.280 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.252958e-01 | 0.280 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.319334e-01 | 0.274 |
| R-HSA-75153 | Apoptotic execution phase | 5.319334e-01 | 0.274 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 5.345146e-01 | 0.272 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.384787e-01 | 0.269 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.449328e-01 | 0.264 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.449328e-01 | 0.264 |
| R-HSA-70326 | Glucose metabolism | 5.495331e-01 | 0.260 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.512971e-01 | 0.259 |
| R-HSA-9748787 | Azathioprine ADME | 5.575728e-01 | 0.254 |
| R-HSA-9864848 | Complex IV assembly | 5.637610e-01 | 0.249 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.737887e-01 | 0.241 |
| R-HSA-1221632 | Meiotic synapsis | 5.758802e-01 | 0.240 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.758802e-01 | 0.240 |
| R-HSA-9609690 | HCMV Early Events | 5.822317e-01 | 0.235 |
| R-HSA-9753281 | Paracetamol ADME | 5.876642e-01 | 0.231 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.894264e-01 | 0.230 |
| R-HSA-114608 | Platelet degranulation | 5.932690e-01 | 0.227 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.934334e-01 | 0.227 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.934334e-01 | 0.227 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.946996e-01 | 0.226 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.046361e-01 | 0.219 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.047317e-01 | 0.218 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.157174e-01 | 0.211 |
| R-HSA-6805567 | Keratinization | 6.159335e-01 | 0.210 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.194175e-01 | 0.208 |
| R-HSA-112043 | PLC beta mediated events | 6.210957e-01 | 0.207 |
| R-HSA-9707616 | Heme signaling | 6.263991e-01 | 0.203 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.316286e-01 | 0.200 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.316286e-01 | 0.200 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.418699e-01 | 0.193 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.468837e-01 | 0.189 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.511183e-01 | 0.186 |
| R-HSA-112040 | G-protein mediated events | 6.518277e-01 | 0.186 |
| R-HSA-196071 | Metabolism of steroid hormones | 6.518277e-01 | 0.186 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.567027e-01 | 0.183 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.567027e-01 | 0.183 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.601565e-01 | 0.180 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.709239e-01 | 0.173 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.755327e-01 | 0.170 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.800772e-01 | 0.167 |
| R-HSA-4086398 | Ca2+ pathway | 6.800772e-01 | 0.167 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.845584e-01 | 0.165 |
| R-HSA-380287 | Centrosome maturation | 6.889770e-01 | 0.162 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.889770e-01 | 0.162 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.018667e-01 | 0.154 |
| R-HSA-9659379 | Sensory processing of sound | 7.060440e-01 | 0.151 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.060440e-01 | 0.151 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.101629e-01 | 0.149 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.299117e-01 | 0.137 |
| R-HSA-9609646 | HCMV Infection | 7.318335e-01 | 0.136 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.336976e-01 | 0.134 |
| R-HSA-5619102 | SLC transporter disorders | 7.337045e-01 | 0.134 |
| R-HSA-72306 | tRNA processing | 7.444214e-01 | 0.128 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.447414e-01 | 0.128 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.468216e-01 | 0.127 |
| R-HSA-73884 | Base Excision Repair | 7.518493e-01 | 0.124 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.518493e-01 | 0.124 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.522159e-01 | 0.124 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.522159e-01 | 0.124 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.553291e-01 | 0.122 |
| R-HSA-5668914 | Diseases of metabolism | 7.554926e-01 | 0.122 |
| R-HSA-611105 | Respiratory electron transport | 7.647535e-01 | 0.116 |
| R-HSA-2029481 | FCGR activation | 7.654795e-01 | 0.116 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.687689e-01 | 0.114 |
| R-HSA-2168880 | Scavenging of heme from plasma | 7.752106e-01 | 0.111 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.783641e-01 | 0.109 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 7.783641e-01 | 0.109 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.875628e-01 | 0.104 |
| R-HSA-5617833 | Cilium Assembly | 7.926239e-01 | 0.101 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.934831e-01 | 0.100 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.969762e-01 | 0.099 |
| R-HSA-418346 | Platelet homeostasis | 8.102763e-01 | 0.091 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.257095e-01 | 0.083 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.352973e-01 | 0.078 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.376110e-01 | 0.077 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.376110e-01 | 0.077 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.421419e-01 | 0.075 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.421419e-01 | 0.075 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.443599e-01 | 0.073 |
| R-HSA-9748784 | Drug ADME | 8.482873e-01 | 0.071 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.549930e-01 | 0.068 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.575999e-01 | 0.067 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.616062e-01 | 0.065 |
| R-HSA-15869 | Metabolism of nucleotides | 8.756522e-01 | 0.058 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.759081e-01 | 0.058 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.770311e-01 | 0.057 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.797467e-01 | 0.056 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.065386e-01 | 0.043 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.082923e-01 | 0.042 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.153735e-01 | 0.038 |
| R-HSA-418555 | G alpha (s) signalling events | 9.316040e-01 | 0.031 |
| R-HSA-8957322 | Metabolism of steroids | 9.549352e-01 | 0.020 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.566032e-01 | 0.019 |
| R-HSA-397014 | Muscle contraction | 9.623613e-01 | 0.017 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.623613e-01 | 0.017 |
| R-HSA-112316 | Neuronal System | 9.689556e-01 | 0.014 |
| R-HSA-416476 | G alpha (q) signalling events | 9.820723e-01 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 9.837242e-01 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 9.931304e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.958810e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.962295e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.986749e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.991275e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996904e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.857 | 0.129 | 1 | 0.812 |
JNK2 |
0.842 | 0.319 | 1 | 0.736 |
PKR |
0.841 | -0.013 | 1 | 0.767 |
VRK2 |
0.840 | -0.163 | 1 | 0.821 |
GCK |
0.840 | 0.039 | 1 | 0.754 |
BMPR1B |
0.839 | 0.283 | 1 | 0.790 |
MOS |
0.838 | 0.215 | 1 | 0.828 |
TAK1 |
0.838 | -0.100 | 1 | 0.758 |
ALK4 |
0.837 | 0.123 | -2 | 0.867 |
JNK3 |
0.837 | 0.287 | 1 | 0.765 |
CLK3 |
0.836 | 0.430 | 1 | 0.869 |
PASK |
0.835 | 0.146 | -3 | 0.858 |
BMPR2 |
0.834 | -0.087 | -2 | 0.882 |
TNIK |
0.834 | -0.006 | 3 | 0.853 |
P38B |
0.834 | 0.305 | 1 | 0.744 |
PRP4 |
0.833 | 0.239 | -3 | 0.787 |
ALK2 |
0.833 | 0.162 | -2 | 0.851 |
MINK |
0.833 | -0.060 | 1 | 0.730 |
DAPK2 |
0.833 | 0.026 | -3 | 0.844 |
MPSK1 |
0.833 | 0.145 | 1 | 0.738 |
EEF2K |
0.833 | -0.018 | 3 | 0.826 |
NLK |
0.832 | 0.216 | 1 | 0.861 |
KHS2 |
0.832 | 0.055 | 1 | 0.743 |
LATS1 |
0.832 | 0.150 | -3 | 0.848 |
P38A |
0.832 | 0.278 | 1 | 0.784 |
TGFBR1 |
0.832 | 0.175 | -2 | 0.848 |
NIK |
0.832 | -0.047 | -3 | 0.852 |
BRAF |
0.831 | -0.103 | -4 | 0.826 |
KHS1 |
0.831 | 0.015 | 1 | 0.725 |
VRK1 |
0.831 | -0.199 | 2 | 0.783 |
GRK7 |
0.831 | 0.219 | 1 | 0.774 |
LRRK2 |
0.831 | -0.174 | 2 | 0.789 |
TAO3 |
0.831 | 0.003 | 1 | 0.747 |
CDKL1 |
0.831 | 0.164 | -3 | 0.797 |
TTK |
0.830 | -0.031 | -2 | 0.830 |
ALPHAK3 |
0.830 | -0.020 | -1 | 0.759 |
MEK1 |
0.830 | -0.184 | 2 | 0.797 |
PDK1 |
0.830 | -0.047 | 1 | 0.771 |
ICK |
0.830 | 0.209 | -3 | 0.830 |
PRPK |
0.830 | -0.032 | -1 | 0.839 |
MST3 |
0.830 | 0.027 | 2 | 0.791 |
CAMLCK |
0.829 | 0.011 | -2 | 0.818 |
PDHK3_TYR |
0.829 | 0.327 | 4 | 0.876 |
MEKK2 |
0.829 | -0.108 | 2 | 0.742 |
HPK1 |
0.828 | -0.008 | 1 | 0.745 |
MAP3K15 |
0.828 | -0.087 | 1 | 0.714 |
MST2 |
0.827 | -0.115 | 1 | 0.750 |
ASK1 |
0.827 | -0.180 | 1 | 0.711 |
CAMK1B |
0.826 | 0.037 | -3 | 0.843 |
HIPK1 |
0.826 | 0.297 | 1 | 0.790 |
TAO2 |
0.826 | -0.126 | 2 | 0.794 |
DLK |
0.825 | -0.121 | 1 | 0.786 |
BIKE |
0.825 | 0.025 | 1 | 0.710 |
P38G |
0.825 | 0.287 | 1 | 0.681 |
ACVR2B |
0.825 | 0.139 | -2 | 0.829 |
MAK |
0.825 | 0.323 | -2 | 0.789 |
MST1 |
0.825 | -0.151 | 1 | 0.730 |
HGK |
0.825 | -0.086 | 3 | 0.847 |
NEK5 |
0.824 | -0.146 | 1 | 0.748 |
MEK5 |
0.824 | -0.282 | 2 | 0.769 |
LKB1 |
0.824 | -0.111 | -3 | 0.792 |
NEK1 |
0.824 | -0.188 | 1 | 0.722 |
BMPR1A |
0.823 | 0.211 | 1 | 0.771 |
COT |
0.823 | 0.246 | 2 | 0.848 |
SKMLCK |
0.823 | 0.129 | -2 | 0.844 |
CDK1 |
0.822 | 0.306 | 1 | 0.756 |
ANKRD3 |
0.822 | -0.154 | 1 | 0.797 |
OSR1 |
0.822 | -0.102 | 2 | 0.741 |
ACVR2A |
0.821 | 0.111 | -2 | 0.815 |
PDHK4_TYR |
0.821 | 0.179 | 2 | 0.860 |
NEK11 |
0.821 | -0.144 | 1 | 0.757 |
MEKK3 |
0.821 | -0.102 | 1 | 0.746 |
P38D |
0.821 | 0.296 | 1 | 0.677 |
PBK |
0.820 | 0.012 | 1 | 0.721 |
ATR |
0.820 | -0.041 | 1 | 0.759 |
DMPK1 |
0.819 | 0.073 | -3 | 0.766 |
DAPK3 |
0.819 | 0.035 | -3 | 0.803 |
DYRK2 |
0.818 | 0.298 | 1 | 0.776 |
ERK5 |
0.818 | 0.132 | 1 | 0.812 |
MAP2K6_TYR |
0.818 | 0.117 | -1 | 0.861 |
BMPR2_TYR |
0.818 | 0.124 | -1 | 0.874 |
JNK1 |
0.818 | 0.239 | 1 | 0.739 |
MEKK6 |
0.818 | -0.179 | 1 | 0.712 |
AAK1 |
0.818 | 0.083 | 1 | 0.620 |
YSK4 |
0.817 | -0.134 | 1 | 0.719 |
PDHK1_TYR |
0.817 | 0.107 | -1 | 0.882 |
RAF1 |
0.816 | -0.058 | 1 | 0.789 |
MAP2K4_TYR |
0.816 | 0.047 | -1 | 0.857 |
TESK1_TYR |
0.816 | 0.000 | 3 | 0.864 |
GRK6 |
0.816 | 0.064 | 1 | 0.819 |
CAMKK2 |
0.816 | -0.237 | -2 | 0.714 |
MEKK1 |
0.816 | -0.227 | 1 | 0.743 |
CDK5 |
0.815 | 0.265 | 1 | 0.783 |
MYO3A |
0.815 | -0.145 | 1 | 0.712 |
CAMKK1 |
0.815 | -0.271 | -2 | 0.722 |
NEK8 |
0.814 | -0.236 | 2 | 0.754 |
CAMK2G |
0.814 | 0.011 | 2 | 0.814 |
ERK1 |
0.814 | 0.263 | 1 | 0.733 |
MYO3B |
0.814 | -0.128 | 2 | 0.765 |
ZAK |
0.813 | -0.173 | 1 | 0.732 |
PKMYT1_TYR |
0.813 | 0.014 | 3 | 0.827 |
EPHA6 |
0.813 | 0.110 | -1 | 0.864 |
NEK4 |
0.813 | -0.225 | 1 | 0.712 |
PIM1 |
0.813 | 0.145 | -3 | 0.796 |
ROCK2 |
0.812 | 0.041 | -3 | 0.784 |
ERK2 |
0.812 | 0.191 | 1 | 0.761 |
YSK1 |
0.812 | -0.163 | 2 | 0.747 |
SMMLCK |
0.812 | -0.046 | -3 | 0.797 |
PIM3 |
0.811 | 0.139 | -3 | 0.842 |
CDKL5 |
0.811 | 0.166 | -3 | 0.788 |
CDC7 |
0.811 | 0.119 | 1 | 0.809 |
GRK5 |
0.810 | -0.053 | -3 | 0.840 |
MLK2 |
0.810 | -0.147 | 2 | 0.764 |
CHAK2 |
0.810 | 0.009 | -1 | 0.818 |
MOK |
0.810 | 0.237 | 1 | 0.770 |
MAP2K7_TYR |
0.810 | -0.174 | 2 | 0.822 |
GRK1 |
0.809 | 0.219 | -2 | 0.798 |
DAPK1 |
0.809 | 0.036 | -3 | 0.791 |
PLK1 |
0.809 | -0.041 | -2 | 0.796 |
TLK2 |
0.809 | -0.061 | 1 | 0.707 |
HIPK4 |
0.808 | 0.271 | 1 | 0.801 |
PKN3 |
0.808 | 0.044 | -3 | 0.812 |
HIPK2 |
0.808 | 0.326 | 1 | 0.711 |
CDK3 |
0.808 | 0.288 | 1 | 0.706 |
MLK1 |
0.808 | -0.097 | 2 | 0.758 |
CLK4 |
0.807 | 0.199 | -3 | 0.778 |
TXK |
0.807 | 0.149 | 1 | 0.787 |
DYRK1A |
0.807 | 0.236 | 1 | 0.800 |
STLK3 |
0.807 | -0.297 | 1 | 0.688 |
SRPK1 |
0.807 | 0.236 | -3 | 0.766 |
CDK14 |
0.806 | 0.243 | 1 | 0.763 |
GRK2 |
0.806 | 0.042 | -2 | 0.761 |
DYRK1B |
0.806 | 0.258 | 1 | 0.754 |
HIPK3 |
0.806 | 0.222 | 1 | 0.770 |
MEK2 |
0.806 | -0.376 | 2 | 0.751 |
LIMK2_TYR |
0.806 | -0.008 | -3 | 0.846 |
MTOR |
0.806 | 0.073 | 1 | 0.785 |
EPHB4 |
0.805 | 0.030 | -1 | 0.827 |
DSTYK |
0.805 | -0.006 | 2 | 0.861 |
PINK1_TYR |
0.805 | -0.203 | 1 | 0.795 |
WNK1 |
0.805 | -0.003 | -2 | 0.862 |
CDK17 |
0.804 | 0.267 | 1 | 0.690 |
GSK3A |
0.804 | 0.126 | 4 | 0.443 |
CDK18 |
0.804 | 0.300 | 1 | 0.725 |
DYRK4 |
0.804 | 0.300 | 1 | 0.731 |
LOK |
0.804 | -0.147 | -2 | 0.707 |
CDK16 |
0.804 | 0.278 | 1 | 0.704 |
PERK |
0.804 | -0.207 | -2 | 0.839 |
TSSK2 |
0.804 | -0.004 | -5 | 0.846 |
CLK2 |
0.804 | 0.323 | -3 | 0.771 |
PDHK4 |
0.803 | -0.277 | 1 | 0.807 |
MST4 |
0.803 | 0.049 | 2 | 0.822 |
RIPK3 |
0.802 | -0.045 | 3 | 0.718 |
PKCD |
0.802 | 0.030 | 2 | 0.731 |
NUAK2 |
0.802 | 0.059 | -3 | 0.841 |
YES1 |
0.802 | 0.017 | -1 | 0.854 |
DCAMKL1 |
0.802 | 0.035 | -3 | 0.788 |
MASTL |
0.802 | -0.274 | -2 | 0.789 |
SRPK3 |
0.801 | 0.161 | -3 | 0.733 |
ABL2 |
0.801 | 0.012 | -1 | 0.791 |
EPHA4 |
0.801 | 0.033 | 2 | 0.775 |
RET |
0.801 | -0.133 | 1 | 0.745 |
AMPKA1 |
0.801 | 0.011 | -3 | 0.840 |
FGR |
0.801 | -0.026 | 1 | 0.789 |
BLK |
0.800 | 0.121 | -1 | 0.856 |
HASPIN |
0.800 | -0.004 | -1 | 0.663 |
LCK |
0.800 | 0.087 | -1 | 0.848 |
MLK3 |
0.800 | -0.030 | 2 | 0.686 |
NEK9 |
0.800 | -0.235 | 2 | 0.775 |
RIPK1 |
0.800 | -0.195 | 1 | 0.744 |
CSF1R |
0.800 | -0.051 | 3 | 0.759 |
TLK1 |
0.800 | -0.136 | -2 | 0.866 |
PKN2 |
0.800 | 0.021 | -3 | 0.819 |
CDK2 |
0.800 | 0.166 | 1 | 0.817 |
FYN |
0.799 | 0.128 | -1 | 0.840 |
P70S6KB |
0.799 | 0.043 | -3 | 0.785 |
PIM2 |
0.799 | 0.079 | -3 | 0.744 |
MST1R |
0.799 | -0.132 | 3 | 0.783 |
ERK7 |
0.799 | 0.047 | 2 | 0.490 |
HRI |
0.798 | -0.262 | -2 | 0.853 |
SRMS |
0.798 | 0.012 | 1 | 0.801 |
MLK4 |
0.798 | -0.082 | 2 | 0.663 |
SLK |
0.798 | -0.132 | -2 | 0.665 |
WNK4 |
0.797 | -0.158 | -2 | 0.857 |
DRAK1 |
0.797 | -0.030 | 1 | 0.766 |
CDK8 |
0.797 | 0.243 | 1 | 0.765 |
DYRK3 |
0.797 | 0.196 | 1 | 0.779 |
DNAPK |
0.797 | -0.004 | 1 | 0.641 |
HCK |
0.797 | -0.008 | -1 | 0.838 |
TGFBR2 |
0.797 | 0.001 | -2 | 0.822 |
BUB1 |
0.796 | 0.033 | -5 | 0.772 |
ABL1 |
0.796 | -0.021 | -1 | 0.787 |
TSSK1 |
0.796 | 0.038 | -3 | 0.860 |
RSK2 |
0.796 | 0.125 | -3 | 0.776 |
PDHK1 |
0.796 | -0.290 | 1 | 0.790 |
CDK6 |
0.796 | 0.193 | 1 | 0.739 |
TBK1 |
0.796 | -0.051 | 1 | 0.697 |
CAMK2B |
0.796 | 0.113 | 2 | 0.808 |
CLK1 |
0.796 | 0.217 | -3 | 0.749 |
CDK7 |
0.796 | 0.232 | 1 | 0.771 |
TAO1 |
0.796 | -0.172 | 1 | 0.665 |
FER |
0.796 | -0.101 | 1 | 0.812 |
GSK3B |
0.796 | 0.023 | 4 | 0.433 |
TYRO3 |
0.796 | -0.165 | 3 | 0.765 |
MARK4 |
0.796 | 0.013 | 4 | 0.831 |
CAMK2D |
0.795 | 0.017 | -3 | 0.806 |
ROS1 |
0.795 | -0.140 | 3 | 0.731 |
KIT |
0.795 | -0.063 | 3 | 0.766 |
PLK3 |
0.795 | -0.062 | 2 | 0.762 |
LIMK1_TYR |
0.795 | -0.252 | 2 | 0.800 |
INSRR |
0.795 | -0.063 | 3 | 0.712 |
JAK2 |
0.795 | -0.159 | 1 | 0.741 |
ITK |
0.794 | -0.018 | -1 | 0.790 |
JAK3 |
0.794 | -0.101 | 1 | 0.731 |
CDK13 |
0.794 | 0.207 | 1 | 0.753 |
TYK2 |
0.794 | -0.245 | 1 | 0.740 |
DCAMKL2 |
0.794 | -0.020 | -3 | 0.802 |
SGK3 |
0.793 | 0.061 | -3 | 0.753 |
EPHB2 |
0.793 | -0.002 | -1 | 0.813 |
IRAK4 |
0.793 | -0.179 | 1 | 0.711 |
MET |
0.793 | -0.033 | 3 | 0.761 |
AKT2 |
0.793 | 0.080 | -3 | 0.704 |
CRIK |
0.793 | 0.057 | -3 | 0.714 |
FGFR2 |
0.793 | -0.097 | 3 | 0.775 |
EPHB1 |
0.793 | -0.049 | 1 | 0.789 |
CDK4 |
0.793 | 0.189 | 1 | 0.724 |
ROCK1 |
0.793 | -0.003 | -3 | 0.745 |
CDK10 |
0.793 | 0.247 | 1 | 0.752 |
DDR1 |
0.793 | -0.191 | 4 | 0.786 |
KDR |
0.792 | -0.075 | 3 | 0.735 |
MRCKA |
0.792 | 0.014 | -3 | 0.744 |
MYLK4 |
0.792 | 0.004 | -2 | 0.727 |
ATM |
0.791 | -0.048 | 1 | 0.697 |
HUNK |
0.791 | -0.179 | 2 | 0.768 |
CDK12 |
0.791 | 0.209 | 1 | 0.732 |
EPHB3 |
0.791 | -0.049 | -1 | 0.813 |
NEK2 |
0.791 | -0.217 | 2 | 0.746 |
TNK2 |
0.791 | -0.059 | 3 | 0.741 |
PTK2 |
0.790 | 0.123 | -1 | 0.822 |
P90RSK |
0.790 | 0.075 | -3 | 0.779 |
IKKB |
0.790 | -0.014 | -2 | 0.745 |
NEK7 |
0.790 | -0.179 | -3 | 0.796 |
CAMK2A |
0.790 | 0.094 | 2 | 0.813 |
CHK1 |
0.790 | -0.082 | -3 | 0.790 |
BMX |
0.789 | -0.025 | -1 | 0.713 |
MRCKB |
0.789 | 0.011 | -3 | 0.732 |
PINK1 |
0.789 | -0.209 | 1 | 0.808 |
AMPKA2 |
0.788 | 0.010 | -3 | 0.812 |
IKKE |
0.788 | -0.089 | 1 | 0.693 |
CK1D |
0.788 | 0.144 | -3 | 0.606 |
PLK2 |
0.788 | -0.001 | -3 | 0.747 |
NEK6 |
0.788 | -0.066 | -2 | 0.868 |
ULK2 |
0.788 | -0.223 | 2 | 0.722 |
RSK4 |
0.788 | 0.131 | -3 | 0.764 |
SYK |
0.787 | 0.117 | -1 | 0.791 |
SGK1 |
0.787 | 0.086 | -3 | 0.626 |
EPHA7 |
0.787 | -0.020 | 2 | 0.761 |
FLT1 |
0.787 | -0.058 | -1 | 0.825 |
MERTK |
0.787 | -0.073 | 3 | 0.746 |
GRK4 |
0.787 | -0.062 | -2 | 0.848 |
IKKA |
0.787 | 0.049 | -2 | 0.754 |
FLT3 |
0.786 | -0.175 | 3 | 0.767 |
TTBK2 |
0.786 | -0.160 | 2 | 0.657 |
PAK1 |
0.786 | -0.026 | -2 | 0.745 |
KIS |
0.786 | 0.326 | 1 | 0.780 |
PKCA |
0.786 | -0.000 | 2 | 0.664 |
CHAK1 |
0.785 | -0.209 | 2 | 0.703 |
FGFR1 |
0.785 | -0.159 | 3 | 0.737 |
NDR1 |
0.785 | 0.013 | -3 | 0.824 |
FGFR3 |
0.785 | -0.091 | 3 | 0.747 |
TEK |
0.785 | -0.154 | 3 | 0.701 |
CDK19 |
0.784 | 0.248 | 1 | 0.736 |
IRE1 |
0.784 | -0.125 | 1 | 0.707 |
GRK3 |
0.784 | 0.052 | -2 | 0.728 |
PTK2B |
0.784 | 0.006 | -1 | 0.770 |
TEC |
0.784 | -0.076 | -1 | 0.726 |
JAK1 |
0.784 | -0.098 | 1 | 0.689 |
SRC |
0.784 | 0.005 | -1 | 0.836 |
SRPK2 |
0.783 | 0.190 | -3 | 0.687 |
PRKD1 |
0.783 | 0.105 | -3 | 0.804 |
FRK |
0.783 | -0.053 | -1 | 0.839 |
SMG1 |
0.783 | -0.130 | 1 | 0.698 |
EGFR |
0.783 | -0.021 | 1 | 0.668 |
EPHA3 |
0.783 | -0.107 | 2 | 0.739 |
CDK9 |
0.783 | 0.164 | 1 | 0.759 |
ERBB2 |
0.783 | -0.133 | 1 | 0.740 |
LYN |
0.783 | -0.046 | 3 | 0.683 |
PDGFRB |
0.782 | -0.244 | 3 | 0.777 |
WNK3 |
0.782 | -0.292 | 1 | 0.739 |
PKCZ |
0.782 | -0.069 | 2 | 0.711 |
AXL |
0.782 | -0.158 | 3 | 0.747 |
NDR2 |
0.782 | 0.109 | -3 | 0.842 |
PAK2 |
0.782 | -0.105 | -2 | 0.723 |
PKCB |
0.781 | -0.004 | 2 | 0.676 |
NEK3 |
0.781 | -0.280 | 1 | 0.683 |
EPHA8 |
0.781 | -0.017 | -1 | 0.815 |
NEK10_TYR |
0.781 | -0.175 | 1 | 0.633 |
IRE2 |
0.781 | -0.129 | 2 | 0.678 |
EPHA5 |
0.780 | -0.027 | 2 | 0.757 |
MAPKAPK3 |
0.780 | -0.005 | -3 | 0.756 |
TNNI3K_TYR |
0.780 | -0.125 | 1 | 0.735 |
CK1A2 |
0.780 | 0.120 | -3 | 0.608 |
WEE1_TYR |
0.779 | -0.152 | -1 | 0.713 |
MSK1 |
0.779 | 0.048 | -3 | 0.738 |
PKACG |
0.779 | 0.019 | -2 | 0.685 |
AKT1 |
0.779 | 0.047 | -3 | 0.718 |
RSK3 |
0.779 | 0.054 | -3 | 0.760 |
MARK2 |
0.779 | -0.013 | 4 | 0.741 |
PKCH |
0.779 | -0.079 | 2 | 0.649 |
CAMK4 |
0.779 | -0.123 | -3 | 0.804 |
TNK1 |
0.778 | -0.183 | 3 | 0.744 |
MELK |
0.778 | -0.062 | -3 | 0.786 |
AURB |
0.778 | -0.003 | -2 | 0.598 |
BTK |
0.778 | -0.230 | -1 | 0.745 |
PKCG |
0.778 | -0.022 | 2 | 0.678 |
CK1E |
0.778 | 0.139 | -3 | 0.653 |
QSK |
0.778 | 0.022 | 4 | 0.807 |
MATK |
0.778 | -0.119 | -1 | 0.721 |
SSTK |
0.777 | -0.030 | 4 | 0.791 |
ALK |
0.777 | -0.188 | 3 | 0.682 |
CHK2 |
0.777 | 0.000 | -3 | 0.645 |
LATS2 |
0.777 | 0.027 | -5 | 0.759 |
FGFR4 |
0.777 | -0.065 | -1 | 0.757 |
ERBB4 |
0.777 | 0.030 | 1 | 0.700 |
EPHA1 |
0.777 | -0.124 | 3 | 0.741 |
MARK3 |
0.776 | 0.026 | 4 | 0.771 |
LTK |
0.776 | -0.185 | 3 | 0.707 |
MAPKAPK2 |
0.776 | 0.096 | -3 | 0.729 |
PRKD3 |
0.776 | 0.014 | -3 | 0.738 |
CAMK1D |
0.776 | -0.010 | -3 | 0.685 |
CK2A2 |
0.776 | 0.116 | 1 | 0.695 |
PRKD2 |
0.776 | 0.095 | -3 | 0.770 |
NTRK1 |
0.776 | -0.235 | -1 | 0.784 |
CAMK1G |
0.776 | -0.032 | -3 | 0.751 |
INSR |
0.775 | -0.181 | 3 | 0.683 |
NIM1 |
0.775 | -0.091 | 3 | 0.750 |
QIK |
0.775 | -0.120 | -3 | 0.805 |
PAK3 |
0.775 | -0.096 | -2 | 0.734 |
PLK4 |
0.775 | -0.113 | 2 | 0.572 |
DDR2 |
0.774 | -0.076 | 3 | 0.709 |
AURC |
0.774 | 0.061 | -2 | 0.605 |
FAM20C |
0.774 | 0.189 | 2 | 0.690 |
PKACB |
0.774 | 0.081 | -2 | 0.616 |
PDGFRA |
0.774 | -0.311 | 3 | 0.775 |
AURA |
0.774 | -0.002 | -2 | 0.578 |
IRAK1 |
0.774 | -0.362 | -1 | 0.722 |
PTK6 |
0.774 | -0.276 | -1 | 0.708 |
PKG2 |
0.773 | 0.010 | -2 | 0.616 |
PKCE |
0.773 | -0.000 | 2 | 0.659 |
GCN2 |
0.773 | -0.207 | 2 | 0.748 |
FLT4 |
0.773 | -0.221 | 3 | 0.722 |
MARK1 |
0.772 | -0.051 | 4 | 0.785 |
CSK |
0.772 | -0.144 | 2 | 0.763 |
NTRK3 |
0.772 | -0.170 | -1 | 0.738 |
MNK1 |
0.772 | -0.008 | -2 | 0.746 |
YANK3 |
0.772 | -0.022 | 2 | 0.408 |
MSK2 |
0.771 | -0.010 | -3 | 0.740 |
EPHA2 |
0.771 | -0.027 | -1 | 0.773 |
ULK1 |
0.771 | -0.249 | -3 | 0.760 |
MNK2 |
0.769 | -0.021 | -2 | 0.739 |
NTRK2 |
0.768 | -0.289 | 3 | 0.724 |
CK2A1 |
0.768 | 0.100 | 1 | 0.675 |
SBK |
0.768 | 0.056 | -3 | 0.587 |
STK33 |
0.767 | -0.208 | 2 | 0.575 |
ZAP70 |
0.767 | 0.045 | -1 | 0.706 |
BCKDK |
0.767 | -0.211 | -1 | 0.763 |
PKCI |
0.766 | -0.090 | 2 | 0.675 |
NUAK1 |
0.765 | -0.042 | -3 | 0.778 |
PKCT |
0.764 | -0.084 | 2 | 0.659 |
SIK |
0.763 | -0.009 | -3 | 0.750 |
RIPK2 |
0.763 | -0.388 | 1 | 0.691 |
PHKG1 |
0.763 | -0.067 | -3 | 0.814 |
IGF1R |
0.762 | -0.156 | 3 | 0.623 |
AKT3 |
0.762 | 0.065 | -3 | 0.648 |
P70S6K |
0.762 | -0.015 | -3 | 0.691 |
PRKX |
0.760 | 0.119 | -3 | 0.712 |
CAMK1A |
0.759 | -0.023 | -3 | 0.659 |
YANK2 |
0.759 | -0.045 | 2 | 0.421 |
PKACA |
0.758 | 0.039 | -2 | 0.563 |
TTBK1 |
0.758 | -0.204 | 2 | 0.584 |
BRSK1 |
0.757 | -0.024 | -3 | 0.777 |
PAK6 |
0.753 | -0.003 | -2 | 0.645 |
MUSK |
0.753 | -0.207 | 1 | 0.648 |
FES |
0.753 | -0.134 | -1 | 0.697 |
BRSK2 |
0.752 | -0.099 | -3 | 0.789 |
PKN1 |
0.751 | -0.033 | -3 | 0.711 |
SNRK |
0.749 | -0.269 | 2 | 0.618 |
MAPKAPK5 |
0.748 | -0.132 | -3 | 0.687 |
CK1G1 |
0.743 | 0.060 | -3 | 0.641 |
PHKG2 |
0.742 | -0.096 | -3 | 0.784 |
PAK5 |
0.734 | -0.074 | -2 | 0.575 |
CK1G3 |
0.734 | 0.049 | -3 | 0.487 |
PAK4 |
0.725 | -0.063 | -2 | 0.585 |
CK1G2 |
0.719 | 0.049 | -3 | 0.569 |
CK1A |
0.717 | 0.082 | -3 | 0.529 |
PKG1 |
0.716 | -0.077 | -2 | 0.521 |