Motif 1189 (n=90)

Position-wise Probabilities

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uniprot genes site source protein function
A0A096LP55 UQCRHL T11 ochoa Cytochrome b-c1 complex subunit 6-like, mitochondrial May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}.
B2RUZ4 SMIM1 Y10 ochoa Small integral membrane protein 1 (Vel blood group antigen) Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}.
J3KQ70 INO80B-WBP1 T10 ochoa HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) None
O15440 ABCC5 Y10 ochoa ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). {ECO:0000250|UniProtKB:Q9R1X5, ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:10893247, ECO:0000269|PubMed:12435799, ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538, ECO:0000269|PubMed:15899835, ECO:0000269|PubMed:17229149, ECO:0000269|PubMed:24836561, ECO:0000269|PubMed:25964343, ECO:0000269|PubMed:26515061}.
O60869 EDF1 T10 ochoa Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.
O75170 PPP6R2 T10 ochoa|psp Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.
P00338 LDHA Y10 ochoa|psp L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}.
P02545 LMNA T10 ochoa|psp Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P07476 IVL T10 ochoa Involucrin Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
P07919 UQCRH T11 ochoa Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}.
P11413 G6PD T10 ochoa Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}.
P12956 XRCC6 T10 ochoa X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}.
P14618 PKM T10 ochoa Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P16402 H1-3 T10 ochoa Histone H1.3 (Histone H1c) (Histone H1s-2) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16989 YBX3 T10 ochoa Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.
P17029 ZKSCAN1 T10 ochoa Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) May be involved in transcriptional regulation.
P18850 ATF6 T10 ochoa Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.
P22736 NR4A1 T10 ochoa Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}.
P24844 MYL9 T10 psp Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}.
P28289 TMOD1 Y10 ochoa Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}.
P31949 S100A11 T10 psp Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}.
P34947 GRK5 T10 psp G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}.
P38435 GGCX T10 ochoa Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). {ECO:0000269|PubMed:17073445}.
P42566 EPS15 T10 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P50402 EMD T10 ochoa Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P51965 UBE2E1 T10 ochoa Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050). {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}.
P53567 CEBPG T10 ochoa CCAAT/enhancer-binding protein gamma (C/EBP gamma) Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}.
P61247 RPS3A T10 psp Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P62310 LSM3 T10 ochoa U6 snRNA-associated Sm-like protein LSm3 Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.
P62753 RPS6 T10 ochoa Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}.
P63165 SUMO1 T10 ochoa Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.
P63215 GNG3 T10 ochoa Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P63244 RACK1 T10 ochoa Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}.
Q08495 DMTN T10 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q12891 HYAL2 T10 ochoa Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210). {ECO:0000269|PubMed:28081210, ECO:0000269|PubMed:9712871}.
Q13541 EIF4EBP1 T10 ochoa Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}.
Q13568 IRF5 T10 psp Interferon regulatory factor 5 (IRF-5) Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.
Q14974 KPNB1 T10 ochoa Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}.
Q15651 HMGN3 T10 ochoa High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
Q16623 STX1A T10 ochoa Syntaxin-1A (Neuron-specific antigen HPC-1) Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}.
Q3T8J9 GON4L T10 ochoa GON-4-like protein (GON-4 homolog) Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.
Q5T0Z8 C6orf132 T10 ochoa Uncharacterized protein C6orf132 None
Q5T6S3 PHF19 T10 ochoa PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q6ZSS7 MFSD6 T10 ochoa Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) None
Q7Z7L9 ZSCAN2 T10 ochoa Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}.
Q7Z7L9 ZSCAN2 T11 ochoa Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}.
Q86VR2 RETREG3 T10 ochoa Reticulophagy regulator 3 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}.
Q86WQ0 NR2C2AP T10 ochoa Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein) May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}.
Q8IWZ3 ANKHD1 T10 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IY18 SMC5 T10 ochoa Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}.
Q8N0S6 CENPL T10 ochoa Centromere protein L (CENP-L) (Interphase centromere complex protein 33) Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}.
Q8TAP9 MPLKIP T10 ochoa M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
Q8WUM0 NUP133 T10 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WW01 TSEN15 T10 ochoa tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15) Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492). {ECO:0000269|PubMed:15109492, ECO:0000269|PubMed:27392077}.
Q92536 SLC7A6 T10 ochoa Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}.
Q92616 GCN1 T10 ochoa Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}.
Q96A32 MYL11 T10 ochoa Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}.
Q96ET8 TVP23C T10 ochoa Golgi apparatus membrane protein TVP23 homolog C None
Q96FZ5 CMTM7 T10 ochoa CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) None
Q96RD7 PANX1 Y10 psp Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). {ECO:0000250|UniProtKB:Q9JIP4, ECO:0000269|PubMed:15304325, ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926}.; FUNCTION: [Caspase-activated pannexin-1]: During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells. {ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926, ECO:0000269|PubMed:32494015}.
Q99618 CDCA3 T10 ochoa Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.
Q9BPY8 HOPX T10 ochoa Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1) Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}.
Q9BQ67 GRWD1 T10 ochoa Glutamate-rich WD repeat-containing protein 1 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.
Q9BTX7 TTPAL T10 ochoa Alpha-tocopherol transfer protein-like May act as a protein that binds a hydrophobic ligand. {ECO:0000305}.
Q9C086 INO80B T10 ochoa INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}.
Q9GZX9 TWSG1 T10 ochoa Twisted gastrulation protein homolog 1 May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.
Q9H0U9 TSPYL1 T10 ochoa Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) None
Q9H1K6 TLNRD1 T10 ochoa Talin rod domain-containing protein 1 (Mesoderm development candidate 1) Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. {ECO:0000269|PubMed:22179486}.
Q9H2H9 SLC38A1 T11 ochoa Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}.
Q9H813 PACC1 Y10 ochoa Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}.
Q9H8V3 ECT2 T10 ochoa Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}.
Q9HB90 RRAGC T10 ochoa Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}.
Q9NWV8 BABAM1 T10 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9NX76 CMTM6 T10 ochoa CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.
Q9NXH3 PPP1R14D T10 ochoa Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}.
Q9NYZ1 TVP23B T10 ochoa Golgi apparatus membrane protein TVP23 homolog B None
Q9P0K8 FOXJ2 T10 ochoa Forkhead box protein J2 (Fork head homologous X) [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}.
Q9UBF6 RNF7 T10 psp RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581). {ECO:0000250|UniProtKB:Q9WTZ1, ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:38574733}.; FUNCTION: [Isoform 2]: Inactive. {ECO:0000269|PubMed:11506706}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:23300442}.
Q9UKT5 FBXO4 T10 ochoa F-box only protein 4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10531035, PubMed:18598945, PubMed:20181953, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:18598945). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (By similarity). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). {ECO:0000250|UniProtKB:Q8CHQ0, ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:29142209}.
Q9Y2Z0 SUGT1 T10 ochoa Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Q9Y4P1 ATG4B T10 ochoa Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.
P08758 ANXA5 T10 Sugiyama Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Q16576 RBBP7 T10 Sugiyama Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
P25789 PSMA4 T10 Sugiyama Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
O43813 LANCL1 Y10 Sugiyama Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}.
P31483 TIA1 Y10 Sugiyama Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1) RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:11106748, PubMed:12486009, PubMed:17488725, PubMed:8576255). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}.
P51674 GPM6A T10 GPS6|SIGNOR|ELM|iPTMNet|EPSD Neuronal membrane glycoprotein M6-a (M6a) Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.
P21673 SAT1 T10 ELM|iPTMNet Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}.
P22612 PRKACG T10 Sugiyama cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
Q96D96 HVCN1 T10 SIGNOR Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16554753, PubMed:20037153, PubMed:20548053, PubMed:22020278, PubMed:27859356, PubMed:30478045, PubMed:37669933). Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation (PubMed:20144758, PubMed:30478045, PubMed:37669933). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:20037153, PubMed:30478045). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (PubMed:20548053). {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:20144758, ECO:0000269|PubMed:20548053, ECO:0000269|PubMed:22020278, ECO:0000269|PubMed:27859356, ECO:0000269|PubMed:30478045, ECO:0000269|PubMed:37669933}.
Download
reactome_id name p -log10_p
R-HSA-68882 Mitotic Anaphase 0.000023 4.645
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.000023 4.630
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.000024 4.616
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.000031 4.514
R-HSA-8953897 Cellular responses to stimuli 0.000142 3.849
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.000250 3.602
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.000250 3.602
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.000463 3.334
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.000490 3.310
R-HSA-166208 mTORC1-mediated signalling 0.000816 3.088
R-HSA-2980766 Nuclear Envelope Breakdown 0.000854 3.069
R-HSA-2262752 Cellular responses to stress 0.000929 3.032
R-HSA-418990 Adherens junctions interactions 0.000887 3.052
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.001196 2.922
R-HSA-68886 M Phase 0.001166 2.933
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.001662 2.779
R-HSA-421270 Cell-cell junction organization 0.001856 2.731
R-HSA-1640170 Cell Cycle 0.002461 2.609
R-HSA-212300 PRC2 methylates histones and DNA 0.002759 2.559
R-HSA-446728 Cell junction organization 0.003139 2.503
R-HSA-140342 Apoptosis induced DNA fragmentation 0.003243 2.489
R-HSA-774815 Nucleosome assembly 0.004935 2.307
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.004935 2.307
R-HSA-165159 MTOR signalling 0.004201 2.377
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.004282 2.368
R-HSA-69278 Cell Cycle, Mitotic 0.004468 2.350
R-HSA-75153 Apoptotic execution phase 0.005196 2.284
R-HSA-9711097 Cellular response to starvation 0.005638 2.249
R-HSA-9766229 Degradation of CDH1 0.006027 2.220
R-HSA-70171 Glycolysis 0.005811 2.236
R-HSA-1500931 Cell-Cell communication 0.005981 2.223
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.006567 2.183
R-HSA-445355 Smooth Muscle Contraction 0.007253 2.139
R-HSA-9764561 Regulation of CDH1 Function 0.008616 2.065
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.008979 2.047
R-HSA-8943724 Regulation of PTEN gene transcription 0.009730 2.012
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.009730 2.012
R-HSA-70326 Glucose metabolism 0.010238 1.990
R-HSA-844456 The NLRP3 inflammasome 0.010560 1.976
R-HSA-68875 Mitotic Prophase 0.011048 1.957
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.011412 1.943
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.011573 1.937
R-HSA-9673240 Defective gamma-carboxylation of F9 0.031480 1.502
R-HSA-164843 2-LTR circle formation 0.079820 1.098
R-HSA-159740 Gamma-carboxylation of protein precursors 0.091527 1.038
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.091527 1.038
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.103086 0.987
R-HSA-8964315 G beta:gamma signalling through BTK 0.114499 0.941
R-HSA-176412 Phosphorylation of the APC/C 0.120152 0.920
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.120152 0.920
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.125769 0.900
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 0.125769 0.900
R-HSA-418217 G beta:gamma signalling through PLC beta 0.136896 0.864
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.142408 0.846
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.147884 0.830
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.153325 0.814
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.047272 1.325
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.048840 1.311
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.056955 1.244
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.058631 1.232
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.058631 1.232
R-HSA-72649 Translation initiation complex formation 0.060324 1.220
R-HSA-1296041 Activation of G protein gated Potassium channels 0.180021 0.745
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.180021 0.745
R-HSA-1296059 G protein gated Potassium channels 0.180021 0.745
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.062033 1.207
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.063760 1.195
R-HSA-72702 Ribosomal scanning and start codon recognition 0.063760 1.195
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.070823 1.150
R-HSA-383280 Nuclear Receptor transcription pathway 0.105370 0.977
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.121928 0.914
R-HSA-141424 Amplification of signal from the kinetochores 0.121928 0.914
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.134735 0.871
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.136899 0.864
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.145629 0.837
R-HSA-72689 Formation of a pool of free 40S subunits 0.147830 0.830
R-HSA-192823 Viral mRNA Translation 0.165668 0.781
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.177003 0.752
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.179284 0.746
R-HSA-180746 Nuclear import of Rev protein 0.028737 1.542
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.050427 1.297
R-HSA-8964616 G beta:gamma signalling through CDC42 0.125769 0.900
R-HSA-202040 G-protein activation 0.153325 0.814
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.188456 0.725
R-HSA-156902 Peptide chain elongation 0.128293 0.892
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.188456 0.725
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.038276 1.417
R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.153325 0.814
R-HSA-6803529 FGFR2 alternative splicing 0.164106 0.785
R-HSA-428930 Thromboxane signalling through TP receptor 0.174750 0.758
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.091446 1.039
R-HSA-453276 Regulation of mitotic cell cycle 0.091446 1.039
R-HSA-69618 Mitotic Spindle Checkpoint 0.034815 1.458
R-HSA-9634597 GPER1 signaling 0.050427 1.297
R-HSA-6798695 Neutrophil degranulation 0.034143 1.467
R-HSA-5626978 TNFR1-mediated ceramide production 0.037658 1.424
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.049896 1.302
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 0.103086 0.987
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.131350 0.882
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.185260 0.732
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.128992 0.889
R-HSA-2467813 Separation of Sister Chromatids 0.029886 1.525
R-HSA-72737 Cap-dependent Translation Initiation 0.051347 1.289
R-HSA-9636249 Inhibition of nitric oxide production 0.031480 1.502
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 0.049896 1.302
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.142408 0.846
R-HSA-72764 Eukaryotic Translation Termination 0.147830 0.830
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.041194 1.385
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.045723 1.340
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.153325 0.814
R-HSA-72613 Eukaryotic Translation Initiation 0.051347 1.289
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.067964 1.168
R-HSA-9865881 Complex III assembly 0.016097 1.793
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.103086 0.987
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.125769 0.900
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.035441 1.450
R-HSA-163615 PKA activation 0.136896 0.864
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.136896 0.864
R-HSA-164378 PKA activation in glucagon signalling 0.136896 0.864
R-HSA-500657 Presynaptic function of Kainate receptors 0.136896 0.864
R-HSA-177243 Interactions of Rev with host cellular proteins 0.036848 1.434
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.036848 1.434
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.039725 1.401
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.169445 0.771
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.060324 1.220
R-HSA-418555 G alpha (s) signalling events 0.122822 0.911
R-HSA-9948299 Ribosome-associated quality control 0.077839 1.109
R-HSA-156842 Eukaryotic Translation Elongation 0.139070 0.857
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.174750 0.758
R-HSA-8951664 Neddylation 0.069519 1.158
R-HSA-156711 Polo-like kinase mediated events 0.136896 0.864
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.039725 1.401
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.039725 1.401
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.045723 1.340
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.164106 0.785
R-HSA-3214815 HDACs deacetylate histones 0.062033 1.207
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.036848 1.434
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.036848 1.434
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.074447 1.128
R-HSA-422356 Regulation of insulin secretion 0.033266 1.478
R-HSA-352238 Breakdown of the nuclear lamina 0.019008 1.721
R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells 0.067964 1.168
R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 0.067964 1.168
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.097324 1.012
R-HSA-163359 Glucagon signaling in metabolic regulation 0.027465 1.561
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.028737 1.542
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.125769 0.900
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.035441 1.450
R-HSA-9710421 Defective pyroptosis 0.042684 1.370
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.153325 0.814
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.047272 1.325
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.174750 0.758
R-HSA-5689901 Metalloprotease DUBs 0.185260 0.732
R-HSA-416482 G alpha (12/13) signalling events 0.105370 0.977
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.179284 0.746
R-HSA-9609690 HCMV Early Events 0.159532 0.797
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.169445 0.771
R-HSA-69052 Switching of origins to a post-replicative state 0.095366 1.021
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.020338 1.692
R-HSA-351200 Interconversion of polyamines 0.103086 0.987
R-HSA-6784531 tRNA processing in the nucleus 0.074447 1.128
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.091446 1.039
R-HSA-2408557 Selenocysteine synthesis 0.161172 0.793
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.099927 1.000
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.170187 0.769
R-HSA-5619507 Activation of HOX genes during differentiation 0.170187 0.769
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.142408 0.846
R-HSA-5689603 UCH proteinases 0.101335 0.994
R-HSA-2142845 Hyaluronan metabolism 0.028737 1.542
R-HSA-112307 Transmission across Electrical Synapses 0.037658 1.424
R-HSA-112303 Electric Transmission Across Gap Junctions 0.037658 1.424
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.073911 1.131
R-HSA-9668250 Defective factor IX causes hemophilia B 0.079820 1.098
R-HSA-1300642 Sperm Motility And Taxes 0.079820 1.098
R-HSA-877312 Regulation of IFNG signaling 0.097324 1.012
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 0.120152 0.920
R-HSA-1169408 ISG15 antiviral mechanism 0.016524 1.782
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.185260 0.732
R-HSA-3928663 EPHA-mediated growth cone collapse 0.190465 0.720
R-HSA-163685 Integration of energy metabolism 0.075533 1.122
R-HSA-5610787 Hedgehog 'off' state 0.158933 0.799
R-HSA-445717 Aquaporin-mediated transport 0.072628 1.139
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.019252 1.716
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.158733 0.799
R-HSA-68867 Assembly of the pre-replicative complex 0.028840 1.540
R-HSA-162592 Integration of provirus 0.091527 1.038
R-HSA-162909 Host Interactions of HIV factors 0.059260 1.227
R-HSA-5250971 Toxicity of botulinum toxin type C (botC) 0.043796 1.359
R-HSA-6799990 Metal sequestration by antimicrobial proteins 0.079820 1.098
R-HSA-5682910 LGI-ADAM interactions 0.085692 1.067
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 0.085692 1.067
R-HSA-174362 Transport and metabolism of PAPS 0.114499 0.941
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.114499 0.941
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.190465 0.720
R-HSA-909733 Interferon alpha/beta signaling 0.050397 1.298
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.124041 0.906
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.181571 0.741
R-HSA-111885 Opioid Signalling 0.167925 0.775
R-HSA-381042 PERK regulates gene expression 0.030033 1.522
R-HSA-9861718 Regulation of pyruvate metabolism 0.047272 1.325
R-HSA-622312 Inflammasomes 0.020338 1.692
R-HSA-9637687 Suppression of phagosomal maturation 0.185260 0.732
R-HSA-351202 Metabolism of polyamines 0.070823 1.150
R-HSA-9842860 Regulation of endogenous retroelements 0.163417 0.787
R-HSA-397014 Muscle contraction 0.062282 1.206
R-HSA-168255 Influenza Infection 0.038800 1.411
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.131350 0.882
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.041194 1.385
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.060324 1.220
R-HSA-2160916 Hyaluronan degradation 0.180021 0.745
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.195637 0.709
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.081867 1.087
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.179284 0.746
R-HSA-9855142 Cellular responses to mechanical stimuli 0.047598 1.322
R-HSA-5693532 DNA Double-Strand Break Repair 0.097359 1.012
R-HSA-70268 Pyruvate metabolism 0.024103 1.618
R-HSA-69620 Cell Cycle Checkpoints 0.033493 1.475
R-HSA-390466 Chaperonin-mediated protein folding 0.126163 0.899
R-HSA-69002 DNA Replication Pre-Initiation 0.043111 1.365
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.069034 1.161
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.117730 0.929
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.096085 1.017
R-HSA-9010642 ROBO receptors bind AKAP5 0.067964 1.168
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.079820 1.098
R-HSA-392517 Rap1 signalling 0.142408 0.846
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.147884 0.830
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.089505 1.048
R-HSA-9860931 Response of endothelial cells to shear stress 0.038024 1.420
R-HSA-877300 Interferon gamma signaling 0.105146 0.978
R-HSA-112315 Transmission across Chemical Synapses 0.177737 0.750
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.114499 0.941
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.120152 0.920
R-HSA-5693606 DNA Double Strand Break Response 0.083757 1.077
R-HSA-381119 Unfolded Protein Response (UPR) 0.018262 1.738
R-HSA-913531 Interferon Signaling 0.015338 1.814
R-HSA-9683610 Maturation of nucleoprotein 0.103086 0.987
R-HSA-8963896 HDL assembly 0.108811 0.963
R-HSA-1187000 Fertilization 0.180021 0.745
R-HSA-69239 Synthesis of DNA 0.177003 0.752
R-HSA-69306 DNA Replication 0.097359 1.012
R-HSA-69242 S Phase 0.091059 1.041
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.078129 1.107
R-HSA-6807070 PTEN Regulation 0.018262 1.738
R-HSA-391251 Protein folding 0.139070 0.857
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.124224 0.906
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.093400 1.030
R-HSA-73886 Chromosome Maintenance 0.056229 1.250
R-HSA-9629569 Protein hydroxylation 0.147884 0.830
R-HSA-210991 Basigin interactions 0.153325 0.814
R-HSA-69202 Cyclin E associated events during G1/S transition 0.089505 1.048
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.101335 0.994
R-HSA-2559583 Cellular Senescence 0.039402 1.404
R-HSA-389948 Co-inhibition by PD-1 0.165694 0.781
R-HSA-9006925 Intracellular signaling by second messengers 0.029156 1.535
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.082550 1.083
R-HSA-3928664 Ephrin signaling 0.136896 0.864
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.174750 0.758
R-HSA-162906 HIV Infection 0.074575 1.127
R-HSA-6807004 Negative regulation of MET activity 0.147884 0.830
R-HSA-5696398 Nucleotide Excision Repair 0.172454 0.763
R-HSA-1257604 PIP3 activates AKT signaling 0.052206 1.282
R-HSA-162594 Early Phase of HIV Life Cycle 0.153325 0.814
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.158733 0.799
R-HSA-400685 Sema4D in semaphorin signaling 0.180021 0.745
R-HSA-382556 ABC-family proteins mediated transport 0.158933 0.799
R-HSA-1632852 Macroautophagy 0.081355 1.090
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.026216 1.581
R-HSA-9694631 Maturation of nucleoprotein 0.142408 0.846
R-HSA-73864 RNA Polymerase I Transcription 0.105370 0.977
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.025002 1.602
R-HSA-376176 Signaling by ROBO receptors 0.054737 1.262
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.190465 0.720
R-HSA-8953750 Transcriptional Regulation by E2F6 0.035441 1.450
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.085660 1.067
R-HSA-9612973 Autophagy 0.101222 0.995
R-HSA-449836 Other interleukin signaling 0.142408 0.846
R-HSA-264876 Insulin processing 0.190465 0.720
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.197692 0.704
R-HSA-352230 Amino acid transport across the plasma membrane 0.069034 1.161
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 0.125769 0.900
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.169445 0.771
R-HSA-9958863 SLC-mediated transport of amino acids 0.083757 1.077
R-HSA-9645723 Diseases of programmed cell death 0.024751 1.606
R-HSA-1834941 STING mediated induction of host immune responses 0.142408 0.846
R-HSA-8963898 Plasma lipoprotein assembly 0.174750 0.758
R-HSA-1630316 Glycosaminoglycan metabolism 0.154958 0.810
R-HSA-5687128 MAPK6/MAPK4 signaling 0.119824 0.921
R-HSA-2559580 Oxidative Stress Induced Senescence 0.163417 0.787
R-HSA-109581 Apoptosis 0.028867 1.540
R-HSA-3214841 PKMTs methylate histone lysines 0.038276 1.417
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.174750 0.758
R-HSA-8863678 Neurodegenerative Diseases 0.174750 0.758
R-HSA-9671793 Diseases of hemostasis 0.142408 0.846
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.094817 1.023
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.190465 0.720
R-HSA-9692914 SARS-CoV-1-host interactions 0.040527 1.392
R-HSA-5357801 Programmed Cell Death 0.056946 1.245
R-HSA-2682334 EPH-Ephrin signaling 0.139070 0.857
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.056229 1.250
R-HSA-168256 Immune System 0.171096 0.767
R-HSA-168249 Innate Immune System 0.153749 0.813
R-HSA-422475 Axon guidance 0.155226 0.809
R-HSA-1280215 Cytokine Signaling in Immune system 0.162654 0.789
R-HSA-168799 Neurotoxicity of clostridium toxins 0.164106 0.785
R-HSA-9828806 Maturation of hRSV A proteins 0.190465 0.720
R-HSA-9675108 Nervous system development 0.189609 0.722
R-HSA-381038 XBP1(S) activates chaperone genes 0.124041 0.906
R-HSA-9679506 SARS-CoV Infections 0.076745 1.115
R-HSA-9678108 SARS-CoV-1 Infection 0.036443 1.438
R-HSA-381070 IRE1alpha activates chaperones 0.136899 0.864
R-HSA-180024 DARPP-32 events 0.200777 0.697
R-HSA-420092 Glucagon-type ligand receptors 0.200777 0.697
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.200777 0.697
R-HSA-5663205 Infectious disease 0.203264 0.692
R-HSA-112316 Neuronal System 0.204266 0.690
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.205884 0.686
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.205884 0.686
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.205884 0.686
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.205884 0.686
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.205884 0.686
R-HSA-8878171 Transcriptional regulation by RUNX1 0.208963 0.680
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.210958 0.676
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.210958 0.676
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.210958 0.676
R-HSA-182971 EGFR downregulation 0.210958 0.676
R-HSA-9694516 SARS-CoV-2 Infection 0.211456 0.675
R-HSA-9705683 SARS-CoV-2-host interactions 0.212268 0.673
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.213982 0.670
R-HSA-1538133 G0 and Early G1 0.216001 0.666
R-HSA-1296065 Inwardly rectifying K+ channels 0.216001 0.666
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.216001 0.666
R-HSA-9675126 Diseases of mitotic cell cycle 0.216001 0.666
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.216001 0.666
R-HSA-1855170 IPs transport between nucleus and cytosol 0.221012 0.656
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.221012 0.656
R-HSA-397795 G-protein beta:gamma signalling 0.221012 0.656
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.221012 0.656
R-HSA-69206 G1/S Transition 0.225696 0.646
R-HSA-390522 Striated Muscle Contraction 0.225991 0.646
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.225991 0.646
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.225991 0.646
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.225991 0.646
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.225991 0.646
R-HSA-180534 Vpu mediated degradation of CD4 0.225991 0.646
R-HSA-5223345 Miscellaneous transport and binding events 0.225991 0.646
R-HSA-73894 DNA Repair 0.226245 0.645
R-HSA-69481 G2/M Checkpoints 0.230396 0.638
R-HSA-392518 Signal amplification 0.230938 0.637
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.230938 0.637
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.230938 0.637
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.230938 0.637
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.235854 0.627
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.235854 0.627
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.235854 0.627
R-HSA-169911 Regulation of Apoptosis 0.235854 0.627
R-HSA-1474165 Reproduction 0.239816 0.620
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.240739 0.618
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.240739 0.618
R-HSA-111933 Calmodulin induced events 0.240739 0.618
R-HSA-111997 CaM pathway 0.240739 0.618
R-HSA-163560 Triglyceride catabolism 0.240739 0.618
R-HSA-69205 G1/S-Specific Transcription 0.240739 0.618
R-HSA-8853659 RET signaling 0.240739 0.618
R-HSA-9843745 Adipogenesis 0.242174 0.616
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.245593 0.610
R-HSA-4641258 Degradation of DVL 0.245593 0.610
R-HSA-4641257 Degradation of AXIN 0.245593 0.610
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.245593 0.610
R-HSA-9609646 HCMV Infection 0.249301 0.603
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.250416 0.601
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.250416 0.601
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.255209 0.593
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.255209 0.593
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.255209 0.593
R-HSA-69541 Stabilization of p53 0.255209 0.593
R-HSA-71336 Pentose phosphate pathway 0.255209 0.593
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.255209 0.593
R-HSA-3858494 Beta-catenin independent WNT signaling 0.256342 0.591
R-HSA-5688426 Deubiquitination 0.257861 0.589
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.259379 0.586
R-HSA-388841 Regulation of T cell activation by CD28 family 0.259578 0.586
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.259972 0.585
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.259972 0.585
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.259972 0.585
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.259972 0.585
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.259972 0.585
R-HSA-5358351 Signaling by Hedgehog 0.261070 0.583
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.264704 0.577
R-HSA-5362768 Hh mutants are degraded by ERAD 0.264704 0.577
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.264704 0.577
R-HSA-8853884 Transcriptional Regulation by VENTX 0.264704 0.577
R-HSA-9932298 Degradation of CRY and PER proteins 0.269406 0.570
R-HSA-6811438 Intra-Golgi traffic 0.269406 0.570
R-HSA-9683701 Translation of Structural Proteins 0.269406 0.570
R-HSA-991365 Activation of GABAB receptors 0.274079 0.562
R-HSA-977444 GABA B receptor activation 0.274079 0.562
R-HSA-111996 Ca-dependent events 0.274079 0.562
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.278722 0.555
R-HSA-9637690 Response of Mtb to phagocytosis 0.278722 0.555
R-HSA-9711123 Cellular response to chemical stress 0.280295 0.552
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.282348 0.549
R-HSA-9907900 Proteasome assembly 0.283335 0.548
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.283335 0.548
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.283335 0.548
R-HSA-3214858 RMTs methylate histone arginines 0.283335 0.548
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.287919 0.541
R-HSA-1489509 DAG and IP3 signaling 0.287919 0.541
R-HSA-4608870 Asymmetric localization of PCP proteins 0.287919 0.541
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.287919 0.541
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.287919 0.541
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.287919 0.541
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.287919 0.541
R-HSA-9824272 Somitogenesis 0.287919 0.541
R-HSA-9679191 Potential therapeutics for SARS 0.291795 0.535
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.292475 0.534
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.292475 0.534
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.292475 0.534
R-HSA-5357905 Regulation of TNFR1 signaling 0.292475 0.534
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.297001 0.527
R-HSA-9609507 Protein localization 0.298870 0.525
R-HSA-73887 Death Receptor Signaling 0.301226 0.521
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.301499 0.521
R-HSA-9824443 Parasitic Infection Pathways 0.302913 0.519
R-HSA-9658195 Leishmania infection 0.302913 0.519
R-HSA-212436 Generic Transcription Pathway 0.304465 0.516
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.305968 0.514
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.305968 0.514
R-HSA-162587 HIV Life Cycle 0.308287 0.511
R-HSA-5658442 Regulation of RAS by GAPs 0.310409 0.508
R-HSA-9748787 Azathioprine ADME 0.310409 0.508
R-HSA-382551 Transport of small molecules 0.311149 0.507
R-HSA-9824446 Viral Infection Pathways 0.313171 0.504
R-HSA-1169091 Activation of NF-kappaB in B cells 0.314822 0.502
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.314822 0.502
R-HSA-5358346 Hedgehog ligand biogenesis 0.314822 0.502
R-HSA-5633007 Regulation of TP53 Activity 0.315335 0.501
R-HSA-68949 Orc1 removal from chromatin 0.319206 0.496
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.319206 0.496
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.319206 0.496
R-HSA-6794361 Neurexins and neuroligins 0.319206 0.496
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.319206 0.496
R-HSA-5339562 Uptake and actions of bacterial toxins 0.319206 0.496
R-HSA-9639288 Amino acids regulate mTORC1 0.323563 0.490
R-HSA-1221632 Meiotic synapsis 0.323563 0.490
R-HSA-8948751 Regulation of PTEN stability and activity 0.323563 0.490
R-HSA-2408522 Selenoamino acid metabolism 0.324708 0.489
R-HSA-72766 Translation 0.325132 0.488
R-HSA-418597 G alpha (z) signalling events 0.332195 0.479
R-HSA-9753281 Paracetamol ADME 0.332195 0.479
R-HSA-193648 NRAGE signals death through JNK 0.336469 0.473
R-HSA-177929 Signaling by EGFR 0.336469 0.473
R-HSA-75893 TNF signaling 0.336469 0.473
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.341032 0.467
R-HSA-72306 tRNA processing 0.341032 0.467
R-HSA-5621481 C-type lectin receptors (CLRs) 0.343354 0.464
R-HSA-9664433 Leishmania parasite growth and survival 0.347992 0.458
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.347992 0.458
R-HSA-194441 Metabolism of non-coding RNA 0.349132 0.457
R-HSA-191859 snRNP Assembly 0.349132 0.457
R-HSA-429914 Deadenylation-dependent mRNA decay 0.349132 0.457
R-HSA-8979227 Triglyceride metabolism 0.349132 0.457
R-HSA-977443 GABA receptor activation 0.353299 0.452
R-HSA-168325 Viral Messenger RNA Synthesis 0.357440 0.447
R-HSA-112043 PLC beta mediated events 0.357440 0.447
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.357440 0.447
R-HSA-9793380 Formation of paraxial mesoderm 0.357440 0.447
R-HSA-611105 Respiratory electron transport 0.359539 0.444
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.361554 0.442
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.361554 0.442
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.365643 0.437
R-HSA-69615 G1/S DNA Damage Checkpoints 0.365643 0.437
R-HSA-373755 Semaphorin interactions 0.365643 0.437
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.373742 0.427
R-HSA-1234174 Cellular response to hypoxia 0.373742 0.427
R-HSA-212165 Epigenetic regulation of gene expression 0.376214 0.425
R-HSA-3700989 Transcriptional Regulation by TP53 0.377444 0.423
R-HSA-69275 G2/M Transition 0.377859 0.423
R-HSA-112040 G-protein mediated events 0.381739 0.418
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.382406 0.417
R-HSA-453274 Mitotic G2-G2/M phases 0.382406 0.417
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.385700 0.414
R-HSA-597592 Post-translational protein modification 0.388583 0.411
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.393545 0.405
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.393545 0.405
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.393545 0.405
R-HSA-68877 Mitotic Prometaphase 0.393714 0.405
R-HSA-74160 Gene expression (Transcription) 0.394965 0.403
R-HSA-5632684 Hedgehog 'on' state 0.397431 0.401
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.397431 0.401
R-HSA-5578749 Transcriptional regulation by small RNAs 0.401292 0.397
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.401292 0.397
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.405128 0.392
R-HSA-4086398 Ca2+ pathway 0.405128 0.392
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.405128 0.392
R-HSA-69473 G2/M DNA damage checkpoint 0.408940 0.388
R-HSA-9013694 Signaling by NOTCH4 0.408940 0.388
R-HSA-1222556 ROS and RNS production in phagocytes 0.408940 0.388
R-HSA-8852135 Protein ubiquitination 0.412728 0.384
R-HSA-73857 RNA Polymerase II Transcription 0.416779 0.380
R-HSA-9694635 Translation of Structural Proteins 0.420232 0.377
R-HSA-5619084 ABC transporter disorders 0.423948 0.373
R-HSA-4086400 PCP/CE pathway 0.423948 0.373
R-HSA-9659379 Sensory processing of sound 0.427641 0.369
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.427641 0.369
R-HSA-5654738 Signaling by FGFR2 0.431310 0.365
R-HSA-9833482 PKR-mediated signaling 0.431310 0.365
R-HSA-6806834 Signaling by MET 0.431310 0.365
R-HSA-5693607 Processing of DNA double-strand break ends 0.434956 0.362
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.437968 0.359
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.438579 0.358
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.438579 0.358
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.442179 0.354
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.445755 0.351
R-HSA-6802957 Oncogenic MAPK signaling 0.449310 0.347
R-HSA-1500620 Meiosis 0.449310 0.347
R-HSA-6794362 Protein-protein interactions at synapses 0.449310 0.347
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.449421 0.347
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.452841 0.344
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.452841 0.344
R-HSA-438064 Post NMDA receptor activation events 0.459837 0.337
R-HSA-1643685 Disease 0.463767 0.334
R-HSA-1236974 ER-Phagosome pathway 0.466745 0.331
R-HSA-8953854 Metabolism of RNA 0.469054 0.329
R-HSA-112310 Neurotransmitter release cycle 0.470166 0.328
R-HSA-373080 Class B/2 (Secretin family receptors) 0.470166 0.328
R-HSA-202424 Downstream TCR signaling 0.470166 0.328
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.480298 0.318
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.480298 0.318
R-HSA-72312 rRNA processing 0.480448 0.318
R-HSA-3247509 Chromatin modifying enzymes 0.484589 0.315
R-HSA-9824439 Bacterial Infection Pathways 0.490825 0.309
R-HSA-392499 Metabolism of proteins 0.491833 0.308
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.493511 0.307
R-HSA-1296071 Potassium Channels 0.496761 0.304
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.496761 0.304
R-HSA-8878159 Transcriptional regulation by RUNX3 0.499991 0.301
R-HSA-425407 SLC-mediated transmembrane transport 0.502087 0.299
R-HSA-190236 Signaling by FGFR 0.503201 0.298
R-HSA-3214847 HATs acetylate histones 0.506390 0.296
R-HSA-193704 p75 NTR receptor-mediated signalling 0.506390 0.296
R-HSA-5619115 Disorders of transmembrane transporters 0.511011 0.292
R-HSA-9009391 Extra-nuclear estrogen signaling 0.512708 0.290
R-HSA-9020702 Interleukin-1 signaling 0.512708 0.290
R-HSA-4839726 Chromatin organization 0.514997 0.288
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.515836 0.287
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.515836 0.287
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.522034 0.282
R-HSA-1280218 Adaptive Immune System 0.528206 0.277
R-HSA-418346 Platelet homeostasis 0.531184 0.275
R-HSA-211000 Gene Silencing by RNA 0.534195 0.272
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.534195 0.272
R-HSA-9700206 Signaling by ALK in cancer 0.534195 0.272
R-HSA-1236975 Antigen processing-Cross presentation 0.537187 0.270
R-HSA-9734767 Developmental Cell Lineages 0.542307 0.266
R-HSA-202403 TCR signaling 0.543115 0.265
R-HSA-416476 G alpha (q) signalling events 0.544217 0.264
R-HSA-6803157 Antimicrobial peptides 0.546050 0.263
R-HSA-1483249 Inositol phosphate metabolism 0.548967 0.260
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.551865 0.258
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.554744 0.256
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.560449 0.251
R-HSA-76002 Platelet activation, signaling and aggregation 0.563016 0.249
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.563274 0.249
R-HSA-9007101 Rab regulation of trafficking 0.568870 0.245
R-HSA-2980736 Peptide hormone metabolism 0.568870 0.245
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.571641 0.243
R-HSA-5693538 Homology Directed Repair 0.571641 0.243
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.572209 0.242
R-HSA-8878166 Transcriptional regulation by RUNX2 0.574395 0.241
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.579850 0.237
R-HSA-3371556 Cellular response to heat stress 0.579850 0.237
R-HSA-71291 Metabolism of amino acids and derivatives 0.587599 0.231
R-HSA-6809371 Formation of the cornified envelope 0.587903 0.231
R-HSA-194138 Signaling by VEGF 0.593187 0.227
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.595803 0.225
R-HSA-114608 Platelet degranulation 0.598403 0.223
R-HSA-195721 Signaling by WNT 0.605870 0.218
R-HSA-9909396 Circadian clock 0.613658 0.212
R-HSA-1266738 Developmental Biology 0.615021 0.211
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.616144 0.210
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.628339 0.202
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.642468 0.192
R-HSA-162599 Late Phase of HIV Life Cycle 0.642468 0.192
R-HSA-8856828 Clathrin-mediated endocytosis 0.644770 0.191
R-HSA-2871837 FCERI mediated NF-kB activation 0.647058 0.189
R-HSA-9758941 Gastrulation 0.658280 0.182
R-HSA-446652 Interleukin-1 family signaling 0.664843 0.177
R-HSA-9610379 HCMV Late Events 0.675504 0.170
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.677596 0.169
R-HSA-5683057 MAPK family signaling cascades 0.683424 0.165
R-HSA-162582 Signal Transduction 0.685631 0.164
R-HSA-5619102 SLC transporter disorders 0.695830 0.157
R-HSA-5689880 Ub-specific processing proteases 0.709303 0.149
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.713043 0.147
R-HSA-201681 TCF dependent signaling in response to WNT 0.727531 0.138
R-HSA-168898 Toll-like Receptor Cascades 0.741294 0.130
R-HSA-72163 mRNA Splicing - Major Pathway 0.746276 0.127
R-HSA-388396 GPCR downstream signalling 0.753856 0.123
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.755956 0.122
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.760658 0.119
R-HSA-418594 G alpha (i) signalling events 0.762221 0.118
R-HSA-109582 Hemostasis 0.762532 0.118
R-HSA-72172 mRNA Splicing 0.763743 0.117
R-HSA-6805567 Keratinization 0.766788 0.115
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.775744 0.110
R-HSA-9730414 MITF-M-regulated melanocyte development 0.777144 0.109
R-HSA-9748784 Drug ADME 0.784261 0.106
R-HSA-8939211 ESR-mediated signaling 0.809312 0.092
R-HSA-202733 Cell surface interactions at the vascular wall 0.809312 0.092
R-HSA-157118 Signaling by NOTCH 0.812994 0.090
R-HSA-372790 Signaling by GPCR 0.818921 0.087
R-HSA-5673001 RAF/MAP kinase cascade 0.864078 0.063
R-HSA-5684996 MAPK1/MAPK3 signaling 0.870145 0.060
R-HSA-8957322 Metabolism of steroids 0.891844 0.050
R-HSA-9006931 Signaling by Nuclear Receptors 0.916206 0.038
R-HSA-449147 Signaling by Interleukins 0.921809 0.035
R-HSA-199991 Membrane Trafficking 0.930905 0.031
R-HSA-1430728 Metabolism 0.941133 0.026
R-HSA-5653656 Vesicle-mediated transport 0.971513 0.013
R-HSA-500792 GPCR ligand binding 0.981269 0.008
R-HSA-556833 Metabolism of lipids 0.999538 0.000
R-HSA-9709957 Sensory Perception 0.999770 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.834 0.039 1 0.744
GCKGCK 0.824 0.043 1 0.742
VRK2VRK2 0.823 -0.076 1 0.802
TAK1TAK1 0.822 -0.045 1 0.745
BMPR1BBMPR1B 0.822 0.306 1 0.836
PKRPKR 0.822 0.006 1 0.753
DAPK2DAPK2 0.821 0.165 -3 0.834
LATS1LATS1 0.820 0.195 -3 0.816
PASKPASK 0.820 0.177 -3 0.829
MOSMOS 0.820 0.244 1 0.830
JNK2JNK2 0.819 0.272 1 0.713
KHS2KHS2 0.819 0.082 1 0.722
CLK3CLK3 0.819 0.431 1 0.837
KHS1KHS1 0.818 0.049 1 0.703
ICKICK 0.818 0.276 -3 0.822
TNIKTNIK 0.818 0.008 3 0.851
ALK4ALK4 0.817 0.129 -2 0.821
EEF2KEEF2K 0.816 0.020 3 0.820
LRRK2LRRK2 0.816 -0.106 2 0.779
BRAFBRAF 0.816 -0.027 -4 0.777
NIKNIK 0.816 0.050 -3 0.833
CAMLCKCAMLCK 0.816 0.130 -2 0.823
MINKMINK 0.816 -0.051 1 0.709
HIPK1HIPK1 0.816 0.320 1 0.779
ALK2ALK2 0.815 0.192 -2 0.806
MAKMAK 0.815 0.338 -2 0.787
HPK1HPK1 0.815 0.027 1 0.723
DMPK1DMPK1 0.815 0.173 -3 0.802
PDK1PDK1 0.814 -0.031 1 0.698
DAPK3DAPK3 0.814 0.166 -3 0.811
TAO3TAO3 0.814 0.031 1 0.718
MST3MST3 0.814 0.050 2 0.775
CDKL1CDKL1 0.813 0.208 -3 0.801
JNK3JNK3 0.813 0.242 1 0.729
MAP3K15MAP3K15 0.813 -0.062 1 0.685
P38AP38A 0.813 0.246 1 0.753
NLKNLK 0.812 0.221 1 0.831
VRK1VRK1 0.812 -0.177 2 0.742
ASK1ASK1 0.812 -0.141 1 0.670
BMPR2BMPR2 0.812 -0.093 -2 0.830
TTKTTK 0.812 -0.049 -2 0.778
P38BP38B 0.811 0.263 1 0.708
MST2MST2 0.811 -0.094 1 0.744
PRP4PRP4 0.810 0.170 -3 0.711
TAO2TAO2 0.810 -0.073 2 0.775
MEK1MEK1 0.810 -0.152 2 0.758
MPSK1MPSK1 0.810 0.076 1 0.677
TGFBR1TGFBR1 0.810 0.173 -2 0.802
SKMLCKSKMLCK 0.810 0.212 -2 0.847
NEK1NEK1 0.810 -0.133 1 0.691
BMPR1ABMPR1A 0.809 0.256 1 0.832
MEKK2MEKK2 0.809 -0.118 2 0.717
HGKHGK 0.809 -0.053 3 0.844
ROCK2ROCK2 0.809 0.147 -3 0.800
ALPHAK3ALPHAK3 0.809 -0.030 -1 0.686
GRK7GRK7 0.808 0.188 1 0.723
CAMK1BCAMK1B 0.808 0.099 -3 0.837
MST1MST1 0.808 -0.129 1 0.713
LKB1LKB1 0.808 -0.100 -3 0.762
OSR1OSR1 0.807 -0.056 2 0.715
MEK5MEK5 0.807 -0.223 2 0.746
NEK5NEK5 0.807 -0.116 1 0.719
MEKK6MEKK6 0.806 -0.100 1 0.714
PRPKPRPK 0.806 -0.062 -1 0.771
DAPK1DAPK1 0.806 0.166 -3 0.797
SMMLCKSMMLCK 0.805 0.086 -3 0.810
ATRATR 0.805 0.036 1 0.750
ACVR2BACVR2B 0.805 0.154 -2 0.767
CAMKK2CAMKK2 0.805 -0.141 -2 0.680
DLKDLK 0.805 -0.090 1 0.770
ANKRD3ANKRD3 0.805 -0.105 1 0.768
DYRK2DYRK2 0.805 0.307 1 0.782
MYO3BMYO3B 0.803 -0.065 2 0.766
ACVR2AACVR2A 0.803 0.122 -2 0.753
MYO3AMYO3A 0.802 -0.088 1 0.703
CLK4CLK4 0.802 0.299 -3 0.792
NEK11NEK11 0.802 -0.155 1 0.715
P38GP38G 0.802 0.246 1 0.658
MOKMOK 0.801 0.266 1 0.761
NEK8NEK8 0.801 -0.140 2 0.747
PBKPBK 0.801 -0.044 1 0.663
HIPK2HIPK2 0.800 0.350 1 0.712
P38DP38D 0.800 0.257 1 0.664
CAMKK1CAMKK1 0.799 -0.191 -2 0.680
BIKEBIKE 0.799 -0.074 1 0.619
YSK1YSK1 0.799 -0.101 2 0.742
MEKK1MEKK1 0.799 -0.175 1 0.729
NEK4NEK4 0.799 -0.161 1 0.693
MEKK3MEKK3 0.799 -0.128 1 0.734
CDK1CDK1 0.798 0.259 1 0.728
HIPK3HIPK3 0.798 0.265 1 0.763
CLK2CLK2 0.797 0.387 -3 0.780
RAF1RAF1 0.796 -0.002 1 0.773
ERK1ERK1 0.796 0.247 1 0.699
PIM1PIM1 0.796 0.177 -3 0.801
COTCOT 0.796 0.168 2 0.782
HIPK4HIPK4 0.796 0.313 1 0.802
DYRK1ADYRK1A 0.796 0.272 1 0.778
ERK5ERK5 0.796 0.103 1 0.777
YSK4YSK4 0.795 -0.134 1 0.692
PIM3PIM3 0.795 0.182 -3 0.824
CDKL5CDKL5 0.795 0.206 -3 0.795
GRK6GRK6 0.794 0.070 1 0.807
LOKLOK 0.794 -0.060 -2 0.712
CDC7CDC7 0.794 0.214 1 0.842
JNK1JNK1 0.793 0.204 1 0.700
SRPK1SRPK1 0.793 0.290 -3 0.776
CDK5CDK5 0.793 0.233 1 0.759
ERK2ERK2 0.793 0.180 1 0.719
GRK5GRK5 0.793 0.013 -3 0.770
CLK1CLK1 0.793 0.307 -3 0.784
ZAKZAK 0.793 -0.161 1 0.713
GRK1GRK1 0.792 0.250 -2 0.781
CHAK2CHAK2 0.792 0.047 -1 0.780
AAK1AAK1 0.792 -0.020 1 0.524
HASPINHASPIN 0.792 0.074 -1 0.685
STLK3STLK3 0.792 -0.248 1 0.676
TLK2TLK2 0.791 -0.024 1 0.722
CDK14CDK14 0.791 0.243 1 0.719
MEK2MEK2 0.791 -0.297 2 0.731
DYRK3DYRK3 0.791 0.266 1 0.785
CAMK2GCAMK2G 0.790 -0.006 2 0.762
MLK2MLK2 0.790 -0.120 2 0.742
DYRK4DYRK4 0.790 0.295 1 0.730
PKCDPKCD 0.790 0.115 2 0.711
ROCK1ROCK1 0.790 0.111 -3 0.778
PKN3PKN3 0.790 0.061 -3 0.807
DYRK1BDYRK1B 0.789 0.251 1 0.739
PLK1PLK1 0.788 -0.038 -2 0.746
SLKSLK 0.788 -0.050 -2 0.670
DCAMKL1DCAMKL1 0.788 0.084 -3 0.811
WNK1WNK1 0.788 0.045 -2 0.832
MRCKBMRCKB 0.787 0.133 -3 0.770
SRPK3SRPK3 0.787 0.212 -3 0.743
MRCKAMRCKA 0.787 0.116 -3 0.777
MLK1MLK1 0.787 -0.070 2 0.744
MST4MST4 0.786 0.094 2 0.809
PIM2PIM2 0.786 0.127 -3 0.776
P70S6KBP70S6KB 0.786 0.121 -3 0.804
BUB1BUB1 0.786 0.064 -5 0.716
GSK3AGSK3A 0.786 0.161 4 0.526
PERKPERK 0.786 -0.156 -2 0.774
TLK1TLK1 0.785 -0.098 -2 0.803
PDHK3_TYRPDHK3_TYR 0.785 0.310 4 0.905
CDK18CDK18 0.785 0.269 1 0.687
RSK2RSK2 0.784 0.210 -3 0.797
SGK3SGK3 0.784 0.142 -3 0.788
CRIKCRIK 0.784 0.106 -3 0.755
CDK17CDK17 0.784 0.237 1 0.657
TAO1TAO1 0.784 -0.119 1 0.641
WNK4WNK4 0.783 -0.095 -2 0.820
PDHK4PDHK4 0.783 -0.223 1 0.773
GRK2GRK2 0.783 0.021 -2 0.709
RIPK3RIPK3 0.783 -0.015 3 0.745
PKN2PKN2 0.783 0.066 -3 0.826
CDK3CDK3 0.783 0.224 1 0.673
AKT2AKT2 0.782 0.168 -3 0.742
DSTYKDSTYK 0.782 0.009 2 0.812
NEK9NEK9 0.781 -0.175 2 0.756
MASTLMASTL 0.781 -0.252 -2 0.753
NUAK2NUAK2 0.781 0.068 -3 0.837
MTORMTOR 0.781 0.027 1 0.733
RIPK1RIPK1 0.781 -0.147 1 0.714
MLK3MLK3 0.780 0.001 2 0.679
CDK16CDK16 0.780 0.235 1 0.661
DNAPKDNAPK 0.780 0.005 1 0.637
MYLK4MYLK4 0.780 0.116 -2 0.757
SGK1SGK1 0.780 0.162 -3 0.677
TSSK2TSSK2 0.780 -0.027 -5 0.786
NEK2NEK2 0.780 -0.110 2 0.746
CDK4CDK4 0.780 0.200 1 0.692
DRAK1DRAK1 0.780 0.001 1 0.727
AMPKA1AMPKA1 0.779 0.009 -3 0.837
CAMK2DCAMK2D 0.779 0.058 -3 0.812
CDK6CDK6 0.779 0.187 1 0.698
GSK3BGSK3B 0.779 0.084 4 0.519
RSK4RSK4 0.778 0.215 -3 0.774
TGFBR2TGFBR2 0.778 0.034 -2 0.778
MLK4MLK4 0.778 -0.048 2 0.644
CAMK2BCAMK2B 0.778 0.130 2 0.737
PDHK1PDHK1 0.778 -0.222 1 0.758
CDK10CDK10 0.778 0.255 1 0.711
ERK7ERK7 0.777 0.058 2 0.502
P90RSKP90RSK 0.777 0.155 -3 0.788
CAMK2ACAMK2A 0.777 0.151 2 0.759
DCAMKL2DCAMKL2 0.776 0.004 -3 0.821
CDK8CDK8 0.776 0.227 1 0.747
PDHK4_TYRPDHK4_TYR 0.776 0.142 2 0.817
HRIHRI 0.776 -0.260 -2 0.786
CDK13CDK13 0.776 0.200 1 0.722
CDK7CDK7 0.776 0.212 1 0.750
IRAK4IRAK4 0.776 -0.144 1 0.690
PKCAPKCA 0.775 0.079 2 0.662
CDK12CDK12 0.775 0.208 1 0.704
MAP2K6_TYRMAP2K6_TYR 0.775 0.124 -1 0.795
PAK1PAK1 0.774 0.093 -2 0.777
MAP2K4_TYRMAP2K4_TYR 0.774 0.104 -1 0.789
PINK1PINK1 0.774 -0.126 1 0.759
CHK1CHK1 0.774 -0.048 -3 0.789
SRPK2SRPK2 0.774 0.253 -3 0.715
AURBAURB 0.773 0.138 -2 0.666
CDK2CDK2 0.773 0.105 1 0.778
PDHK1_TYRPDHK1_TYR 0.773 0.101 -1 0.817
ATMATM 0.773 -0.020 1 0.707
TSSK1TSSK1 0.773 0.019 -3 0.847
PKCZPKCZ 0.772 0.021 2 0.702
PKCBPKCB 0.772 0.080 2 0.668
TESK1_TYRTESK1_TYR 0.772 0.021 3 0.863
MSK1MSK1 0.772 0.169 -3 0.759
BMPR2_TYRBMPR2_TYR 0.772 0.076 -1 0.801
NDR1NDR1 0.772 0.092 -3 0.823
MARK4MARK4 0.772 -0.036 4 0.790
PKMYT1_TYRPKMYT1_TYR 0.771 0.051 3 0.841
NEK7NEK7 0.771 -0.109 -3 0.771
PKCHPKCH 0.771 0.033 2 0.652
AKT1AKT1 0.771 0.146 -3 0.757
CHAK1CHAK1 0.770 -0.129 2 0.716
PAK2PAK2 0.770 0.022 -2 0.758
PKACBPKACB 0.770 0.208 -2 0.677
CHK2CHK2 0.770 0.081 -3 0.705
AURAAURA 0.769 0.134 -2 0.651
AURCAURC 0.769 0.202 -2 0.673
TBK1TBK1 0.769 -0.098 1 0.649
NEK6NEK6 0.769 -0.024 -2 0.801
PKCGPKCG 0.769 0.075 2 0.670
PLK3PLK3 0.768 -0.121 2 0.701
PKG2PKG2 0.768 0.141 -2 0.673
ULK2ULK2 0.768 -0.151 2 0.699
PKACGPKACG 0.768 0.123 -2 0.729
NEK3NEK3 0.768 -0.214 1 0.665
SMG1SMG1 0.768 -0.063 1 0.692
CDK9CDK9 0.767 0.165 1 0.727
EPHA6EPHA6 0.767 0.096 -1 0.785
AMPKA2AMPKA2 0.767 0.018 -3 0.823
MAP2K7_TYRMAP2K7_TYR 0.767 -0.115 2 0.794
PKCEPKCE 0.767 0.097 2 0.658
NDR2NDR2 0.767 0.179 -3 0.823
LIMK2_TYRLIMK2_TYR 0.767 0.065 -3 0.830
HUNKHUNK 0.767 -0.180 2 0.706
MAPKAPK3MAPKAPK3 0.767 0.065 -3 0.784
CDK19CDK19 0.766 0.237 1 0.721
PRKD1PRKD1 0.766 0.134 -3 0.813
CAMK1DCAMK1D 0.766 0.061 -3 0.735
IRE1IRE1 0.766 -0.080 1 0.691
GRK4GRK4 0.766 -0.046 -2 0.796
IKKBIKKB 0.764 -0.026 -2 0.685
PRKD3PRKD3 0.764 0.087 -3 0.779
PAK3PAK3 0.764 0.036 -2 0.763
MNK1MNK1 0.764 0.106 -2 0.781
WNK3WNK3 0.764 -0.221 1 0.715
RSK3RSK3 0.764 0.134 -3 0.782
IRE2IRE2 0.763 -0.079 2 0.671
LATS2LATS2 0.763 0.094 -5 0.730
IKKEIKKE 0.763 -0.102 1 0.653
CAMK4CAMK4 0.763 -0.044 -3 0.809
SBKSBK 0.763 0.130 -3 0.654
MSK2MSK2 0.762 0.110 -3 0.757
PRKD2PRKD2 0.762 0.154 -3 0.803
EPHB4EPHB4 0.762 0.038 -1 0.748
PINK1_TYRPINK1_TYR 0.761 -0.150 1 0.745
GRK3GRK3 0.761 0.031 -2 0.682
TTBK2TTBK2 0.761 -0.167 2 0.617
TXKTXK 0.761 0.125 1 0.815
PKCIPKCI 0.760 0.022 2 0.675
MELKMELK 0.760 -0.021 -3 0.810
IKKAIKKA 0.760 0.040 -2 0.686
MAPKAPK2MAPKAPK2 0.760 0.132 -3 0.761
PLK2PLK2 0.759 -0.065 -3 0.656
CK1DCK1D 0.759 0.047 -3 0.462
MNK2MNK2 0.757 0.078 -2 0.772
QSKQSK 0.757 0.005 4 0.762
CAMK1GCAMK1G 0.757 0.006 -3 0.778
PKACAPKACA 0.757 0.171 -2 0.630
NIM1NIM1 0.757 -0.064 3 0.753
PKCTPKCT 0.756 0.023 2 0.657
PRKXPRKX 0.756 0.239 -3 0.744
EPHA4EPHA4 0.756 0.029 2 0.704
CK2A2CK2A2 0.756 0.119 1 0.718
KISKIS 0.755 0.256 1 0.753
QIKQIK 0.755 -0.109 -3 0.812
LIMK1_TYRLIMK1_TYR 0.755 -0.168 2 0.782
RETRET 0.755 -0.151 1 0.711
BLKBLK 0.754 0.073 -1 0.778
MARK2MARK2 0.754 -0.064 4 0.677
AKT3AKT3 0.754 0.152 -3 0.698
SSTKSSTK 0.754 -0.043 4 0.757
CK1A2CK1A2 0.753 0.034 -3 0.469
ABL2ABL2 0.752 -0.032 -1 0.714
STK33STK33 0.752 -0.160 2 0.540
ROS1ROS1 0.752 -0.101 3 0.745
SRMSSRMS 0.752 0.002 1 0.814
FGRFGR 0.752 -0.093 1 0.754
MARK3MARK3 0.752 -0.026 4 0.709
YES1YES1 0.752 -0.057 -1 0.778
PLK4PLK4 0.752 -0.138 2 0.562
TNK2TNK2 0.751 -0.006 3 0.758
MST1RMST1R 0.751 -0.156 3 0.807
LCKLCK 0.751 0.023 -1 0.765
P70S6KP70S6K 0.751 0.050 -3 0.736
ULK1ULK1 0.751 -0.194 -3 0.718
GCN2GCN2 0.751 -0.166 2 0.725
IRAK1IRAK1 0.751 -0.348 -1 0.646
EPHB1EPHB1 0.750 -0.019 1 0.814
TYRO3TYRO3 0.750 -0.140 3 0.774
JAK2JAK2 0.750 -0.150 1 0.710
FERFER 0.750 -0.103 1 0.816
EPHB2EPHB2 0.750 0.008 -1 0.730
CK1ECK1E 0.750 0.048 -3 0.509
RIPK2RIPK2 0.749 -0.298 1 0.660
INSRRINSRR 0.749 -0.076 3 0.724
MARK1MARK1 0.749 -0.082 4 0.734
CAMK1ACAMK1A 0.749 0.046 -3 0.722
CK2A1CK2A1 0.749 0.109 1 0.698
HCKHCK 0.749 -0.054 -1 0.754
PHKG1PHKG1 0.749 -0.015 -3 0.818
CSF1RCSF1R 0.749 -0.115 3 0.773
TYK2TYK2 0.748 -0.236 1 0.705
ABL1ABL1 0.748 -0.058 -1 0.703
ITKITK 0.748 -0.027 -1 0.698
FYNFYN 0.748 0.031 -1 0.758
DDR1DDR1 0.748 -0.174 4 0.809
PAK6PAK6 0.747 0.131 -2 0.683
BCKDKBCKDK 0.747 -0.186 -1 0.686
JAK3JAK3 0.747 -0.133 1 0.692
EPHB3EPHB3 0.746 -0.043 -1 0.725
EPHA7EPHA7 0.746 0.003 2 0.696
BMXBMX 0.746 -0.020 -1 0.637
SIKSIK 0.745 0.008 -3 0.778
NUAK1NUAK1 0.745 -0.013 -3 0.797
FAM20CFAM20C 0.745 0.109 2 0.597
YANK3YANK3 0.745 -0.058 2 0.343
KDRKDR 0.745 -0.096 3 0.753
METMET 0.743 -0.083 3 0.778
TNNI3K_TYRTNNI3K_TYR 0.742 -0.060 1 0.745
JAK1JAK1 0.742 -0.073 1 0.659
PTK2PTK2 0.742 0.063 -1 0.741
MERTKMERTK 0.742 -0.066 3 0.766
SYKSYK 0.742 0.081 -1 0.717
TECTEC 0.742 -0.050 -1 0.637
KITKIT 0.741 -0.144 3 0.774
FGFR2FGFR2 0.741 -0.164 3 0.786
PKN1PKN1 0.741 0.030 -3 0.757
TNK1TNK1 0.741 -0.094 3 0.760
EPHA3EPHA3 0.738 -0.108 2 0.676
FLT1FLT1 0.738 -0.105 -1 0.750
PDGFRBPDGFRB 0.738 -0.206 3 0.786
DDR2DDR2 0.738 -0.021 3 0.722
PTK2BPTK2B 0.737 -0.020 -1 0.680
TEKTEK 0.737 -0.153 3 0.707
EPHA5EPHA5 0.737 -0.018 2 0.685
SNRKSNRK 0.736 -0.148 2 0.628
FRKFRK 0.736 -0.077 -1 0.764
NEK10_TYRNEK10_TYR 0.736 -0.166 1 0.560
WEE1_TYRWEE1_TYR 0.736 -0.118 -1 0.636
BRSK1BRSK1 0.736 -0.012 -3 0.799
FLT3FLT3 0.736 -0.206 3 0.781
AXLAXL 0.735 -0.156 3 0.761
EPHA8EPHA8 0.735 -0.048 -1 0.722
MAPKAPK5MAPKAPK5 0.735 -0.047 -3 0.724
FGFR1FGFR1 0.734 -0.198 3 0.752
ALKALK 0.734 -0.158 3 0.698
LTKLTK 0.734 -0.154 3 0.729
FGFR3FGFR3 0.734 -0.148 3 0.759
LYNLYN 0.733 -0.098 3 0.712
TTBK1TTBK1 0.733 -0.213 2 0.543
EPHA1EPHA1 0.733 -0.101 3 0.762
ERBB2ERBB2 0.732 -0.185 1 0.687
SRCSRC 0.732 -0.080 -1 0.746
NTRK1NTRK1 0.732 -0.219 -1 0.710
PAK5PAK5 0.732 0.075 -2 0.646
BTKBTK 0.731 -0.214 -1 0.655
PTK6PTK6 0.731 -0.226 -1 0.605
BRSK2BRSK2 0.731 -0.092 -3 0.807
MATKMATK 0.729 -0.140 -1 0.647
EGFREGFR 0.728 -0.105 1 0.603
PDGFRAPDGFRA 0.728 -0.289 3 0.783
PHKG2PHKG2 0.728 -0.030 -3 0.810
YANK2YANK2 0.728 -0.102 2 0.354
INSRINSR 0.728 -0.189 3 0.707
NTRK3NTRK3 0.727 -0.168 -1 0.664
EPHA2EPHA2 0.726 -0.040 -1 0.690
FLT4FLT4 0.726 -0.227 3 0.742
ERBB4ERBB4 0.725 -0.044 1 0.651
NTRK2NTRK2 0.724 -0.254 3 0.743
CSKCSK 0.724 -0.170 2 0.702
PAK4PAK4 0.724 0.085 -2 0.657
FGFR4FGFR4 0.722 -0.135 -1 0.676
CK1G1CK1G1 0.716 -0.009 -3 0.497
PKG1PKG1 0.715 0.065 -2 0.595
IGF1RIGF1R 0.715 -0.174 3 0.646
ZAP70ZAP70 0.714 -0.032 -1 0.635
CK1G3CK1G3 0.709 -0.014 -3 0.345
FESFES 0.708 -0.133 -1 0.603
MUSKMUSK 0.707 -0.215 1 0.571
CK1G2CK1G2 0.696 0.007 -3 0.425
CK1ACK1A 0.694 0.024 -3 0.383