Motif 1189 (n=90)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A096LP55 | UQCRHL | T11 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
B2RUZ4 | SMIM1 | Y10 | ochoa | Small integral membrane protein 1 (Vel blood group antigen) | Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}. |
J3KQ70 | INO80B-WBP1 | T10 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
O15440 | ABCC5 | Y10 | ochoa | ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). {ECO:0000250|UniProtKB:Q9R1X5, ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:10893247, ECO:0000269|PubMed:12435799, ECO:0000269|PubMed:12637526, ECO:0000269|PubMed:12695538, ECO:0000269|PubMed:15899835, ECO:0000269|PubMed:17229149, ECO:0000269|PubMed:24836561, ECO:0000269|PubMed:25964343, ECO:0000269|PubMed:26515061}. |
O60869 | EDF1 | T10 | ochoa | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}. |
O75170 | PPP6R2 | T10 | ochoa|psp | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
P00338 | LDHA | Y10 | ochoa|psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
P02545 | LMNA | T10 | ochoa|psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P07476 | IVL | T10 | ochoa | Involucrin | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
P07919 | UQCRH | T11 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
P11413 | G6PD | T10 | ochoa | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
P12956 | XRCC6 | T10 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
P14618 | PKM | T10 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
P16402 | H1-3 | T10 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P16989 | YBX3 | T10 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
P17029 | ZKSCAN1 | T10 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
P18850 | ATF6 | T10 | ochoa | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] | [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
P22736 | NR4A1 | T10 | ochoa | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
P24844 | MYL9 | T10 | psp | Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}. |
P28289 | TMOD1 | Y10 | ochoa | Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}. |
P31949 | S100A11 | T10 | psp | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
P34947 | GRK5 | T10 | psp | G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}. |
P38435 | GGCX | T10 | ochoa | Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). {ECO:0000269|PubMed:17073445}. |
P42566 | EPS15 | T10 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
P50402 | EMD | T10 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
P51965 | UBE2E1 | T10 | ochoa | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050). {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
P53567 | CEBPG | T10 | ochoa | CCAAT/enhancer-binding protein gamma (C/EBP gamma) | Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}. |
P61247 | RPS3A | T10 | psp | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
P62310 | LSM3 | T10 | ochoa | U6 snRNA-associated Sm-like protein LSm3 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
P62753 | RPS6 | T10 | ochoa | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
P63165 | SUMO1 | T10 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
P63215 | GNG3 | T10 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
P63244 | RACK1 | T10 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
Q08495 | DMTN | T10 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q12891 | HYAL2 | T10 | ochoa | Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) | Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210). {ECO:0000269|PubMed:28081210, ECO:0000269|PubMed:9712871}. |
Q13541 | EIF4EBP1 | T10 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
Q13568 | IRF5 | T10 | psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
Q14974 | KPNB1 | T10 | ochoa | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
Q15651 | HMGN3 | T10 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
Q16623 | STX1A | T10 | ochoa | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
Q3T8J9 | GON4L | T10 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
Q5T0Z8 | C6orf132 | T10 | ochoa | Uncharacterized protein C6orf132 | None |
Q5T6S3 | PHF19 | T10 | ochoa | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
Q6ZSS7 | MFSD6 | T10 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
Q7Z7L9 | ZSCAN2 | T10 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
Q7Z7L9 | ZSCAN2 | T11 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
Q86VR2 | RETREG3 | T10 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
Q86WQ0 | NR2C2AP | T10 | ochoa | Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein) | May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}. |
Q8IWZ3 | ANKHD1 | T10 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
Q8IY18 | SMC5 | T10 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
Q8N0S6 | CENPL | T10 | ochoa | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}. |
Q8TAP9 | MPLKIP | T10 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
Q8WUM0 | NUP133 | T10 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
Q8WW01 | TSEN15 | T10 | ochoa | tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492). {ECO:0000269|PubMed:15109492, ECO:0000269|PubMed:27392077}. |
Q92536 | SLC7A6 | T10 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
Q92616 | GCN1 | T10 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
Q96A32 | MYL11 | T10 | ochoa | Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) | Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}. |
Q96ET8 | TVP23C | T10 | ochoa | Golgi apparatus membrane protein TVP23 homolog C | None |
Q96FZ5 | CMTM7 | T10 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
Q96RD7 | PANX1 | Y10 | psp | Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] | Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). {ECO:0000250|UniProtKB:Q9JIP4, ECO:0000269|PubMed:15304325, ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926}.; FUNCTION: [Caspase-activated pannexin-1]: During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells. {ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926, ECO:0000269|PubMed:32494015}. |
Q99618 | CDCA3 | T10 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
Q9BPY8 | HOPX | T10 | ochoa | Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1) | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}. |
Q9BQ67 | GRWD1 | T10 | ochoa | Glutamate-rich WD repeat-containing protein 1 | Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}. |
Q9BTX7 | TTPAL | T10 | ochoa | Alpha-tocopherol transfer protein-like | May act as a protein that binds a hydrophobic ligand. {ECO:0000305}. |
Q9C086 | INO80B | T10 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
Q9GZX9 | TWSG1 | T10 | ochoa | Twisted gastrulation protein homolog 1 | May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}. |
Q9H0U9 | TSPYL1 | T10 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
Q9H1K6 | TLNRD1 | T10 | ochoa | Talin rod domain-containing protein 1 (Mesoderm development candidate 1) | Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. {ECO:0000269|PubMed:22179486}. |
Q9H2H9 | SLC38A1 | T11 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
Q9H813 | PACC1 | Y10 | ochoa | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) | Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}. |
Q9H8V3 | ECT2 | T10 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
Q9HB90 | RRAGC | T10 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
Q9NWV8 | BABAM1 | T10 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
Q9NX76 | CMTM6 | T10 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
Q9NXH3 | PPP1R14D | T10 | ochoa | Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) | Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}. |
Q9NYZ1 | TVP23B | T10 | ochoa | Golgi apparatus membrane protein TVP23 homolog B | None |
Q9P0K8 | FOXJ2 | T10 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
Q9UBF6 | RNF7 | T10 | psp | RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) | Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581). {ECO:0000250|UniProtKB:Q9WTZ1, ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:38574733}.; FUNCTION: [Isoform 2]: Inactive. {ECO:0000269|PubMed:11506706}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:23300442}. |
Q9UKT5 | FBXO4 | T10 | ochoa | F-box only protein 4 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10531035, PubMed:18598945, PubMed:20181953, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:18598945). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (By similarity). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). {ECO:0000250|UniProtKB:Q8CHQ0, ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:29142209}. |
Q9Y2Z0 | SUGT1 | T10 | ochoa | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
Q9Y4P1 | ATG4B | T10 | ochoa | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
P08758 | ANXA5 | T10 | Sugiyama | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
Q16576 | RBBP7 | T10 | Sugiyama | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
P25789 | PSMA4 | T10 | Sugiyama | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
O43813 | LANCL1 | Y10 | Sugiyama | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}. |
P31483 | TIA1 | Y10 | Sugiyama | Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1) | RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:11106748, PubMed:12486009, PubMed:17488725, PubMed:8576255). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}. |
P51674 | GPM6A | T10 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | Neuronal membrane glycoprotein M6-a (M6a) | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}. |
P21673 | SAT1 | T10 | ELM|iPTMNet | Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) | Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}. |
P22612 | PRKACG | T10 | Sugiyama | cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. |
Q96D96 | HVCN1 | T10 | SIGNOR | Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) | Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16554753, PubMed:20037153, PubMed:20548053, PubMed:22020278, PubMed:27859356, PubMed:30478045, PubMed:37669933). Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation (PubMed:20144758, PubMed:30478045, PubMed:37669933). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:20037153, PubMed:30478045). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (PubMed:20548053). {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:20144758, ECO:0000269|PubMed:20548053, ECO:0000269|PubMed:22020278, ECO:0000269|PubMed:27859356, ECO:0000269|PubMed:30478045, ECO:0000269|PubMed:37669933}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-68882 | Mitotic Anaphase | 0.000023 | 4.645 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000023 | 4.630 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.000024 | 4.616 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.000031 | 4.514 |
R-HSA-8953897 | Cellular responses to stimuli | 0.000142 | 3.849 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.000250 | 3.602 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.000250 | 3.602 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.000463 | 3.334 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.000490 | 3.310 |
R-HSA-166208 | mTORC1-mediated signalling | 0.000816 | 3.088 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000854 | 3.069 |
R-HSA-2262752 | Cellular responses to stress | 0.000929 | 3.032 |
R-HSA-418990 | Adherens junctions interactions | 0.000887 | 3.052 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.001196 | 2.922 |
R-HSA-68886 | M Phase | 0.001166 | 2.933 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.001662 | 2.779 |
R-HSA-421270 | Cell-cell junction organization | 0.001856 | 2.731 |
R-HSA-1640170 | Cell Cycle | 0.002461 | 2.609 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.002759 | 2.559 |
R-HSA-446728 | Cell junction organization | 0.003139 | 2.503 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.003243 | 2.489 |
R-HSA-774815 | Nucleosome assembly | 0.004935 | 2.307 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.004935 | 2.307 |
R-HSA-165159 | MTOR signalling | 0.004201 | 2.377 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.004282 | 2.368 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.004468 | 2.350 |
R-HSA-75153 | Apoptotic execution phase | 0.005196 | 2.284 |
R-HSA-9711097 | Cellular response to starvation | 0.005638 | 2.249 |
R-HSA-9766229 | Degradation of CDH1 | 0.006027 | 2.220 |
R-HSA-70171 | Glycolysis | 0.005811 | 2.236 |
R-HSA-1500931 | Cell-Cell communication | 0.005981 | 2.223 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.006567 | 2.183 |
R-HSA-445355 | Smooth Muscle Contraction | 0.007253 | 2.139 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.008616 | 2.065 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.008979 | 2.047 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.009730 | 2.012 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.009730 | 2.012 |
R-HSA-70326 | Glucose metabolism | 0.010238 | 1.990 |
R-HSA-844456 | The NLRP3 inflammasome | 0.010560 | 1.976 |
R-HSA-68875 | Mitotic Prophase | 0.011048 | 1.957 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.011412 | 1.943 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.011573 | 1.937 |
R-HSA-9673240 | Defective gamma-carboxylation of F9 | 0.031480 | 1.502 |
R-HSA-164843 | 2-LTR circle formation | 0.079820 | 1.098 |
R-HSA-159740 | Gamma-carboxylation of protein precursors | 0.091527 | 1.038 |
R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.091527 | 1.038 |
R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.103086 | 0.987 |
R-HSA-8964315 | G beta:gamma signalling through BTK | 0.114499 | 0.941 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.120152 | 0.920 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.120152 | 0.920 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.125769 | 0.900 |
R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.125769 | 0.900 |
R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.136896 | 0.864 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.142408 | 0.846 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.147884 | 0.830 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.153325 | 0.814 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.047272 | 1.325 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.048840 | 1.311 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.056955 | 1.244 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.058631 | 1.232 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.058631 | 1.232 |
R-HSA-72649 | Translation initiation complex formation | 0.060324 | 1.220 |
R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.180021 | 0.745 |
R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.180021 | 0.745 |
R-HSA-1296059 | G protein gated Potassium channels | 0.180021 | 0.745 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.062033 | 1.207 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.063760 | 1.195 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.063760 | 1.195 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.070823 | 1.150 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.105370 | 0.977 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.121928 | 0.914 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.121928 | 0.914 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.134735 | 0.871 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.136899 | 0.864 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.145629 | 0.837 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.147830 | 0.830 |
R-HSA-192823 | Viral mRNA Translation | 0.165668 | 0.781 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.177003 | 0.752 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.179284 | 0.746 |
R-HSA-180746 | Nuclear import of Rev protein | 0.028737 | 1.542 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.050427 | 1.297 |
R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.125769 | 0.900 |
R-HSA-202040 | G-protein activation | 0.153325 | 0.814 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.188456 | 0.725 |
R-HSA-156902 | Peptide chain elongation | 0.128293 | 0.892 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.188456 | 0.725 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.038276 | 1.417 |
R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.153325 | 0.814 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.164106 | 0.785 |
R-HSA-428930 | Thromboxane signalling through TP receptor | 0.174750 | 0.758 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.091446 | 1.039 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.091446 | 1.039 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.034815 | 1.458 |
R-HSA-9634597 | GPER1 signaling | 0.050427 | 1.297 |
R-HSA-6798695 | Neutrophil degranulation | 0.034143 | 1.467 |
R-HSA-5626978 | TNFR1-mediated ceramide production | 0.037658 | 1.424 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.049896 | 1.302 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.103086 | 0.987 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.131350 | 0.882 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.185260 | 0.732 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.128992 | 0.889 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.029886 | 1.525 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.051347 | 1.289 |
R-HSA-9636249 | Inhibition of nitric oxide production | 0.031480 | 1.502 |
R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.049896 | 1.302 |
R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.142408 | 0.846 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.147830 | 0.830 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.041194 | 1.385 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.045723 | 1.340 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.153325 | 0.814 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.051347 | 1.289 |
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.067964 | 1.168 |
R-HSA-9865881 | Complex III assembly | 0.016097 | 1.793 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.103086 | 0.987 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.125769 | 0.900 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.035441 | 1.450 |
R-HSA-163615 | PKA activation | 0.136896 | 0.864 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.136896 | 0.864 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.136896 | 0.864 |
R-HSA-500657 | Presynaptic function of Kainate receptors | 0.136896 | 0.864 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.036848 | 1.434 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.036848 | 1.434 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.039725 | 1.401 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.169445 | 0.771 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.060324 | 1.220 |
R-HSA-418555 | G alpha (s) signalling events | 0.122822 | 0.911 |
R-HSA-9948299 | Ribosome-associated quality control | 0.077839 | 1.109 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.139070 | 0.857 |
R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.174750 | 0.758 |
R-HSA-8951664 | Neddylation | 0.069519 | 1.158 |
R-HSA-156711 | Polo-like kinase mediated events | 0.136896 | 0.864 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.039725 | 1.401 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.039725 | 1.401 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.045723 | 1.340 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.164106 | 0.785 |
R-HSA-3214815 | HDACs deacetylate histones | 0.062033 | 1.207 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.036848 | 1.434 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.036848 | 1.434 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.074447 | 1.128 |
R-HSA-422356 | Regulation of insulin secretion | 0.033266 | 1.478 |
R-HSA-352238 | Breakdown of the nuclear lamina | 0.019008 | 1.721 |
R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.067964 | 1.168 |
R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.067964 | 1.168 |
R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | 0.097324 | 1.012 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.027465 | 1.561 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.028737 | 1.542 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.125769 | 0.900 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.035441 | 1.450 |
R-HSA-9710421 | Defective pyroptosis | 0.042684 | 1.370 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.153325 | 0.814 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.047272 | 1.325 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.174750 | 0.758 |
R-HSA-5689901 | Metalloprotease DUBs | 0.185260 | 0.732 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.105370 | 0.977 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.179284 | 0.746 |
R-HSA-9609690 | HCMV Early Events | 0.159532 | 0.797 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.169445 | 0.771 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.095366 | 1.021 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.020338 | 1.692 |
R-HSA-351200 | Interconversion of polyamines | 0.103086 | 0.987 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.074447 | 1.128 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.091446 | 1.039 |
R-HSA-2408557 | Selenocysteine synthesis | 0.161172 | 0.793 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.099927 | 1.000 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.170187 | 0.769 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.170187 | 0.769 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.142408 | 0.846 |
R-HSA-5689603 | UCH proteinases | 0.101335 | 0.994 |
R-HSA-2142845 | Hyaluronan metabolism | 0.028737 | 1.542 |
R-HSA-112307 | Transmission across Electrical Synapses | 0.037658 | 1.424 |
R-HSA-112303 | Electric Transmission Across Gap Junctions | 0.037658 | 1.424 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.073911 | 1.131 |
R-HSA-9668250 | Defective factor IX causes hemophilia B | 0.079820 | 1.098 |
R-HSA-1300642 | Sperm Motility And Taxes | 0.079820 | 1.098 |
R-HSA-877312 | Regulation of IFNG signaling | 0.097324 | 1.012 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.120152 | 0.920 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.016524 | 1.782 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.185260 | 0.732 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.190465 | 0.720 |
R-HSA-163685 | Integration of energy metabolism | 0.075533 | 1.122 |
R-HSA-5610787 | Hedgehog 'off' state | 0.158933 | 0.799 |
R-HSA-445717 | Aquaporin-mediated transport | 0.072628 | 1.139 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.019252 | 1.716 |
R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.158733 | 0.799 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.028840 | 1.540 |
R-HSA-162592 | Integration of provirus | 0.091527 | 1.038 |
R-HSA-162909 | Host Interactions of HIV factors | 0.059260 | 1.227 |
R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.043796 | 1.359 |
R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 0.079820 | 1.098 |
R-HSA-5682910 | LGI-ADAM interactions | 0.085692 | 1.067 |
R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.085692 | 1.067 |
R-HSA-174362 | Transport and metabolism of PAPS | 0.114499 | 0.941 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.114499 | 0.941 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.190465 | 0.720 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.050397 | 1.298 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.124041 | 0.906 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.181571 | 0.741 |
R-HSA-111885 | Opioid Signalling | 0.167925 | 0.775 |
R-HSA-381042 | PERK regulates gene expression | 0.030033 | 1.522 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.047272 | 1.325 |
R-HSA-622312 | Inflammasomes | 0.020338 | 1.692 |
R-HSA-9637687 | Suppression of phagosomal maturation | 0.185260 | 0.732 |
R-HSA-351202 | Metabolism of polyamines | 0.070823 | 1.150 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.163417 | 0.787 |
R-HSA-397014 | Muscle contraction | 0.062282 | 1.206 |
R-HSA-168255 | Influenza Infection | 0.038800 | 1.411 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.131350 | 0.882 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.041194 | 1.385 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.060324 | 1.220 |
R-HSA-2160916 | Hyaluronan degradation | 0.180021 | 0.745 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.195637 | 0.709 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.081867 | 1.087 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.179284 | 0.746 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.047598 | 1.322 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.097359 | 1.012 |
R-HSA-70268 | Pyruvate metabolism | 0.024103 | 1.618 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.033493 | 1.475 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.126163 | 0.899 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.043111 | 1.365 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.069034 | 1.161 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.117730 | 0.929 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.096085 | 1.017 |
R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.067964 | 1.168 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.079820 | 1.098 |
R-HSA-392517 | Rap1 signalling | 0.142408 | 0.846 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.147884 | 0.830 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.089505 | 1.048 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.038024 | 1.420 |
R-HSA-877300 | Interferon gamma signaling | 0.105146 | 0.978 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.177737 | 0.750 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.114499 | 0.941 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.120152 | 0.920 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.083757 | 1.077 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.018262 | 1.738 |
R-HSA-913531 | Interferon Signaling | 0.015338 | 1.814 |
R-HSA-9683610 | Maturation of nucleoprotein | 0.103086 | 0.987 |
R-HSA-8963896 | HDL assembly | 0.108811 | 0.963 |
R-HSA-1187000 | Fertilization | 0.180021 | 0.745 |
R-HSA-69239 | Synthesis of DNA | 0.177003 | 0.752 |
R-HSA-69306 | DNA Replication | 0.097359 | 1.012 |
R-HSA-69242 | S Phase | 0.091059 | 1.041 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.078129 | 1.107 |
R-HSA-6807070 | PTEN Regulation | 0.018262 | 1.738 |
R-HSA-391251 | Protein folding | 0.139070 | 0.857 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.124224 | 0.906 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.093400 | 1.030 |
R-HSA-73886 | Chromosome Maintenance | 0.056229 | 1.250 |
R-HSA-9629569 | Protein hydroxylation | 0.147884 | 0.830 |
R-HSA-210991 | Basigin interactions | 0.153325 | 0.814 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.089505 | 1.048 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.101335 | 0.994 |
R-HSA-2559583 | Cellular Senescence | 0.039402 | 1.404 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.165694 | 0.781 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.029156 | 1.535 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.082550 | 1.083 |
R-HSA-3928664 | Ephrin signaling | 0.136896 | 0.864 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.174750 | 0.758 |
R-HSA-162906 | HIV Infection | 0.074575 | 1.127 |
R-HSA-6807004 | Negative regulation of MET activity | 0.147884 | 0.830 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.172454 | 0.763 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.052206 | 1.282 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 0.153325 | 0.814 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.158733 | 0.799 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.180021 | 0.745 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.158933 | 0.799 |
R-HSA-1632852 | Macroautophagy | 0.081355 | 1.090 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.026216 | 1.581 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.142408 | 0.846 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.105370 | 0.977 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.025002 | 1.602 |
R-HSA-376176 | Signaling by ROBO receptors | 0.054737 | 1.262 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.190465 | 0.720 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.035441 | 1.450 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.085660 | 1.067 |
R-HSA-9612973 | Autophagy | 0.101222 | 0.995 |
R-HSA-449836 | Other interleukin signaling | 0.142408 | 0.846 |
R-HSA-264876 | Insulin processing | 0.190465 | 0.720 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.197692 | 0.704 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.069034 | 1.161 |
R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.125769 | 0.900 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.169445 | 0.771 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.083757 | 1.077 |
R-HSA-9645723 | Diseases of programmed cell death | 0.024751 | 1.606 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.142408 | 0.846 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.174750 | 0.758 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.154958 | 0.810 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.119824 | 0.921 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.163417 | 0.787 |
R-HSA-109581 | Apoptosis | 0.028867 | 1.540 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.038276 | 1.417 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.174750 | 0.758 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.174750 | 0.758 |
R-HSA-9671793 | Diseases of hemostasis | 0.142408 | 0.846 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.094817 | 1.023 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.190465 | 0.720 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.040527 | 1.392 |
R-HSA-5357801 | Programmed Cell Death | 0.056946 | 1.245 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.139070 | 0.857 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.056229 | 1.250 |
R-HSA-168256 | Immune System | 0.171096 | 0.767 |
R-HSA-168249 | Innate Immune System | 0.153749 | 0.813 |
R-HSA-422475 | Axon guidance | 0.155226 | 0.809 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.162654 | 0.789 |
R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.164106 | 0.785 |
R-HSA-9828806 | Maturation of hRSV A proteins | 0.190465 | 0.720 |
R-HSA-9675108 | Nervous system development | 0.189609 | 0.722 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.124041 | 0.906 |
R-HSA-9679506 | SARS-CoV Infections | 0.076745 | 1.115 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.036443 | 1.438 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.136899 | 0.864 |
R-HSA-180024 | DARPP-32 events | 0.200777 | 0.697 |
R-HSA-420092 | Glucagon-type ligand receptors | 0.200777 | 0.697 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.200777 | 0.697 |
R-HSA-5663205 | Infectious disease | 0.203264 | 0.692 |
R-HSA-112316 | Neuronal System | 0.204266 | 0.690 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.205884 | 0.686 |
R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.205884 | 0.686 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.205884 | 0.686 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.205884 | 0.686 |
R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.205884 | 0.686 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.208963 | 0.680 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.210958 | 0.676 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.210958 | 0.676 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.210958 | 0.676 |
R-HSA-182971 | EGFR downregulation | 0.210958 | 0.676 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.211456 | 0.675 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.212268 | 0.673 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.213982 | 0.670 |
R-HSA-1538133 | G0 and Early G1 | 0.216001 | 0.666 |
R-HSA-1296065 | Inwardly rectifying K+ channels | 0.216001 | 0.666 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.216001 | 0.666 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.216001 | 0.666 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.216001 | 0.666 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.221012 | 0.656 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.221012 | 0.656 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.221012 | 0.656 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.221012 | 0.656 |
R-HSA-69206 | G1/S Transition | 0.225696 | 0.646 |
R-HSA-390522 | Striated Muscle Contraction | 0.225991 | 0.646 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.225991 | 0.646 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.225991 | 0.646 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.225991 | 0.646 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.225991 | 0.646 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 0.225991 | 0.646 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.225991 | 0.646 |
R-HSA-73894 | DNA Repair | 0.226245 | 0.645 |
R-HSA-69481 | G2/M Checkpoints | 0.230396 | 0.638 |
R-HSA-392518 | Signal amplification | 0.230938 | 0.637 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.230938 | 0.637 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.230938 | 0.637 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.230938 | 0.637 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.235854 | 0.627 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.235854 | 0.627 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.235854 | 0.627 |
R-HSA-169911 | Regulation of Apoptosis | 0.235854 | 0.627 |
R-HSA-1474165 | Reproduction | 0.239816 | 0.620 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.240739 | 0.618 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.240739 | 0.618 |
R-HSA-111933 | Calmodulin induced events | 0.240739 | 0.618 |
R-HSA-111997 | CaM pathway | 0.240739 | 0.618 |
R-HSA-163560 | Triglyceride catabolism | 0.240739 | 0.618 |
R-HSA-69205 | G1/S-Specific Transcription | 0.240739 | 0.618 |
R-HSA-8853659 | RET signaling | 0.240739 | 0.618 |
R-HSA-9843745 | Adipogenesis | 0.242174 | 0.616 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.245593 | 0.610 |
R-HSA-4641258 | Degradation of DVL | 0.245593 | 0.610 |
R-HSA-4641257 | Degradation of AXIN | 0.245593 | 0.610 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.245593 | 0.610 |
R-HSA-9609646 | HCMV Infection | 0.249301 | 0.603 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.250416 | 0.601 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.250416 | 0.601 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.255209 | 0.593 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.255209 | 0.593 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.255209 | 0.593 |
R-HSA-69541 | Stabilization of p53 | 0.255209 | 0.593 |
R-HSA-71336 | Pentose phosphate pathway | 0.255209 | 0.593 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.255209 | 0.593 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.256342 | 0.591 |
R-HSA-5688426 | Deubiquitination | 0.257861 | 0.589 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.259379 | 0.586 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.259578 | 0.586 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.259972 | 0.585 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.259972 | 0.585 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.259972 | 0.585 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.259972 | 0.585 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.259972 | 0.585 |
R-HSA-5358351 | Signaling by Hedgehog | 0.261070 | 0.583 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.264704 | 0.577 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.264704 | 0.577 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.264704 | 0.577 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.264704 | 0.577 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.269406 | 0.570 |
R-HSA-6811438 | Intra-Golgi traffic | 0.269406 | 0.570 |
R-HSA-9683701 | Translation of Structural Proteins | 0.269406 | 0.570 |
R-HSA-991365 | Activation of GABAB receptors | 0.274079 | 0.562 |
R-HSA-977444 | GABA B receptor activation | 0.274079 | 0.562 |
R-HSA-111996 | Ca-dependent events | 0.274079 | 0.562 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.278722 | 0.555 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 0.278722 | 0.555 |
R-HSA-9711123 | Cellular response to chemical stress | 0.280295 | 0.552 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.282348 | 0.549 |
R-HSA-9907900 | Proteasome assembly | 0.283335 | 0.548 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.283335 | 0.548 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.283335 | 0.548 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.283335 | 0.548 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.287919 | 0.541 |
R-HSA-1489509 | DAG and IP3 signaling | 0.287919 | 0.541 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.287919 | 0.541 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.287919 | 0.541 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.287919 | 0.541 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.287919 | 0.541 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.287919 | 0.541 |
R-HSA-9824272 | Somitogenesis | 0.287919 | 0.541 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.291795 | 0.535 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.292475 | 0.534 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.292475 | 0.534 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.292475 | 0.534 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.292475 | 0.534 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.297001 | 0.527 |
R-HSA-9609507 | Protein localization | 0.298870 | 0.525 |
R-HSA-73887 | Death Receptor Signaling | 0.301226 | 0.521 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.301499 | 0.521 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.302913 | 0.519 |
R-HSA-9658195 | Leishmania infection | 0.302913 | 0.519 |
R-HSA-212436 | Generic Transcription Pathway | 0.304465 | 0.516 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.305968 | 0.514 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.305968 | 0.514 |
R-HSA-162587 | HIV Life Cycle | 0.308287 | 0.511 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.310409 | 0.508 |
R-HSA-9748787 | Azathioprine ADME | 0.310409 | 0.508 |
R-HSA-382551 | Transport of small molecules | 0.311149 | 0.507 |
R-HSA-9824446 | Viral Infection Pathways | 0.313171 | 0.504 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.314822 | 0.502 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.314822 | 0.502 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.314822 | 0.502 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.315335 | 0.501 |
R-HSA-68949 | Orc1 removal from chromatin | 0.319206 | 0.496 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.319206 | 0.496 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.319206 | 0.496 |
R-HSA-6794361 | Neurexins and neuroligins | 0.319206 | 0.496 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.319206 | 0.496 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.319206 | 0.496 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.323563 | 0.490 |
R-HSA-1221632 | Meiotic synapsis | 0.323563 | 0.490 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.323563 | 0.490 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.324708 | 0.489 |
R-HSA-72766 | Translation | 0.325132 | 0.488 |
R-HSA-418597 | G alpha (z) signalling events | 0.332195 | 0.479 |
R-HSA-9753281 | Paracetamol ADME | 0.332195 | 0.479 |
R-HSA-193648 | NRAGE signals death through JNK | 0.336469 | 0.473 |
R-HSA-177929 | Signaling by EGFR | 0.336469 | 0.473 |
R-HSA-75893 | TNF signaling | 0.336469 | 0.473 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.341032 | 0.467 |
R-HSA-72306 | tRNA processing | 0.341032 | 0.467 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.343354 | 0.464 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.347992 | 0.458 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.347992 | 0.458 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.349132 | 0.457 |
R-HSA-191859 | snRNP Assembly | 0.349132 | 0.457 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.349132 | 0.457 |
R-HSA-8979227 | Triglyceride metabolism | 0.349132 | 0.457 |
R-HSA-977443 | GABA receptor activation | 0.353299 | 0.452 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.357440 | 0.447 |
R-HSA-112043 | PLC beta mediated events | 0.357440 | 0.447 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.357440 | 0.447 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.357440 | 0.447 |
R-HSA-611105 | Respiratory electron transport | 0.359539 | 0.444 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.361554 | 0.442 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.361554 | 0.442 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.365643 | 0.437 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.365643 | 0.437 |
R-HSA-373755 | Semaphorin interactions | 0.365643 | 0.437 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.373742 | 0.427 |
R-HSA-1234174 | Cellular response to hypoxia | 0.373742 | 0.427 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.376214 | 0.425 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.377444 | 0.423 |
R-HSA-69275 | G2/M Transition | 0.377859 | 0.423 |
R-HSA-112040 | G-protein mediated events | 0.381739 | 0.418 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.382406 | 0.417 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.382406 | 0.417 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.385700 | 0.414 |
R-HSA-597592 | Post-translational protein modification | 0.388583 | 0.411 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.393545 | 0.405 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.393545 | 0.405 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.393545 | 0.405 |
R-HSA-68877 | Mitotic Prometaphase | 0.393714 | 0.405 |
R-HSA-74160 | Gene expression (Transcription) | 0.394965 | 0.403 |
R-HSA-5632684 | Hedgehog 'on' state | 0.397431 | 0.401 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.397431 | 0.401 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.401292 | 0.397 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.401292 | 0.397 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.405128 | 0.392 |
R-HSA-4086398 | Ca2+ pathway | 0.405128 | 0.392 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.405128 | 0.392 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.408940 | 0.388 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.408940 | 0.388 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 0.408940 | 0.388 |
R-HSA-8852135 | Protein ubiquitination | 0.412728 | 0.384 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.416779 | 0.380 |
R-HSA-9694635 | Translation of Structural Proteins | 0.420232 | 0.377 |
R-HSA-5619084 | ABC transporter disorders | 0.423948 | 0.373 |
R-HSA-4086400 | PCP/CE pathway | 0.423948 | 0.373 |
R-HSA-9659379 | Sensory processing of sound | 0.427641 | 0.369 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.427641 | 0.369 |
R-HSA-5654738 | Signaling by FGFR2 | 0.431310 | 0.365 |
R-HSA-9833482 | PKR-mediated signaling | 0.431310 | 0.365 |
R-HSA-6806834 | Signaling by MET | 0.431310 | 0.365 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.434956 | 0.362 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.437968 | 0.359 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.438579 | 0.358 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.438579 | 0.358 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.442179 | 0.354 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.445755 | 0.351 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.449310 | 0.347 |
R-HSA-1500620 | Meiosis | 0.449310 | 0.347 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.449310 | 0.347 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.449421 | 0.347 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.452841 | 0.344 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.452841 | 0.344 |
R-HSA-438064 | Post NMDA receptor activation events | 0.459837 | 0.337 |
R-HSA-1643685 | Disease | 0.463767 | 0.334 |
R-HSA-1236974 | ER-Phagosome pathway | 0.466745 | 0.331 |
R-HSA-8953854 | Metabolism of RNA | 0.469054 | 0.329 |
R-HSA-112310 | Neurotransmitter release cycle | 0.470166 | 0.328 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.470166 | 0.328 |
R-HSA-202424 | Downstream TCR signaling | 0.470166 | 0.328 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.480298 | 0.318 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.480298 | 0.318 |
R-HSA-72312 | rRNA processing | 0.480448 | 0.318 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.484589 | 0.315 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.490825 | 0.309 |
R-HSA-392499 | Metabolism of proteins | 0.491833 | 0.308 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.493511 | 0.307 |
R-HSA-1296071 | Potassium Channels | 0.496761 | 0.304 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.496761 | 0.304 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.499991 | 0.301 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.502087 | 0.299 |
R-HSA-190236 | Signaling by FGFR | 0.503201 | 0.298 |
R-HSA-3214847 | HATs acetylate histones | 0.506390 | 0.296 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.506390 | 0.296 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.511011 | 0.292 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.512708 | 0.290 |
R-HSA-9020702 | Interleukin-1 signaling | 0.512708 | 0.290 |
R-HSA-4839726 | Chromatin organization | 0.514997 | 0.288 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.515836 | 0.287 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.515836 | 0.287 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.522034 | 0.282 |
R-HSA-1280218 | Adaptive Immune System | 0.528206 | 0.277 |
R-HSA-418346 | Platelet homeostasis | 0.531184 | 0.275 |
R-HSA-211000 | Gene Silencing by RNA | 0.534195 | 0.272 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.534195 | 0.272 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.534195 | 0.272 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.537187 | 0.270 |
R-HSA-9734767 | Developmental Cell Lineages | 0.542307 | 0.266 |
R-HSA-202403 | TCR signaling | 0.543115 | 0.265 |
R-HSA-416476 | G alpha (q) signalling events | 0.544217 | 0.264 |
R-HSA-6803157 | Antimicrobial peptides | 0.546050 | 0.263 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.548967 | 0.260 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.551865 | 0.258 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.554744 | 0.256 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.560449 | 0.251 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.563016 | 0.249 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.563274 | 0.249 |
R-HSA-9007101 | Rab regulation of trafficking | 0.568870 | 0.245 |
R-HSA-2980736 | Peptide hormone metabolism | 0.568870 | 0.245 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.571641 | 0.243 |
R-HSA-5693538 | Homology Directed Repair | 0.571641 | 0.243 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.572209 | 0.242 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.574395 | 0.241 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.579850 | 0.237 |
R-HSA-3371556 | Cellular response to heat stress | 0.579850 | 0.237 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.587599 | 0.231 |
R-HSA-6809371 | Formation of the cornified envelope | 0.587903 | 0.231 |
R-HSA-194138 | Signaling by VEGF | 0.593187 | 0.227 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.595803 | 0.225 |
R-HSA-114608 | Platelet degranulation | 0.598403 | 0.223 |
R-HSA-195721 | Signaling by WNT | 0.605870 | 0.218 |
R-HSA-9909396 | Circadian clock | 0.613658 | 0.212 |
R-HSA-1266738 | Developmental Biology | 0.615021 | 0.211 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.616144 | 0.210 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.628339 | 0.202 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.642468 | 0.192 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.642468 | 0.192 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.644770 | 0.191 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.647058 | 0.189 |
R-HSA-9758941 | Gastrulation | 0.658280 | 0.182 |
R-HSA-446652 | Interleukin-1 family signaling | 0.664843 | 0.177 |
R-HSA-9610379 | HCMV Late Events | 0.675504 | 0.170 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.677596 | 0.169 |
R-HSA-5683057 | MAPK family signaling cascades | 0.683424 | 0.165 |
R-HSA-162582 | Signal Transduction | 0.685631 | 0.164 |
R-HSA-5619102 | SLC transporter disorders | 0.695830 | 0.157 |
R-HSA-5689880 | Ub-specific processing proteases | 0.709303 | 0.149 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.713043 | 0.147 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.727531 | 0.138 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.741294 | 0.130 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.746276 | 0.127 |
R-HSA-388396 | GPCR downstream signalling | 0.753856 | 0.123 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.755956 | 0.122 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.760658 | 0.119 |
R-HSA-418594 | G alpha (i) signalling events | 0.762221 | 0.118 |
R-HSA-109582 | Hemostasis | 0.762532 | 0.118 |
R-HSA-72172 | mRNA Splicing | 0.763743 | 0.117 |
R-HSA-6805567 | Keratinization | 0.766788 | 0.115 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.775744 | 0.110 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.777144 | 0.109 |
R-HSA-9748784 | Drug ADME | 0.784261 | 0.106 |
R-HSA-8939211 | ESR-mediated signaling | 0.809312 | 0.092 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.809312 | 0.092 |
R-HSA-157118 | Signaling by NOTCH | 0.812994 | 0.090 |
R-HSA-372790 | Signaling by GPCR | 0.818921 | 0.087 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.864078 | 0.063 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.870145 | 0.060 |
R-HSA-8957322 | Metabolism of steroids | 0.891844 | 0.050 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.916206 | 0.038 |
R-HSA-449147 | Signaling by Interleukins | 0.921809 | 0.035 |
R-HSA-199991 | Membrane Trafficking | 0.930905 | 0.031 |
R-HSA-1430728 | Metabolism | 0.941133 | 0.026 |
R-HSA-5653656 | Vesicle-mediated transport | 0.971513 | 0.013 |
R-HSA-500792 | GPCR ligand binding | 0.981269 | 0.008 |
R-HSA-556833 | Metabolism of lipids | 0.999538 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999770 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
GAK |
0.834 | 0.039 | 1 | 0.744 |
GCK |
0.824 | 0.043 | 1 | 0.742 |
VRK2 |
0.823 | -0.076 | 1 | 0.802 |
TAK1 |
0.822 | -0.045 | 1 | 0.745 |
BMPR1B |
0.822 | 0.306 | 1 | 0.836 |
PKR |
0.822 | 0.006 | 1 | 0.753 |
DAPK2 |
0.821 | 0.165 | -3 | 0.834 |
LATS1 |
0.820 | 0.195 | -3 | 0.816 |
PASK |
0.820 | 0.177 | -3 | 0.829 |
MOS |
0.820 | 0.244 | 1 | 0.830 |
JNK2 |
0.819 | 0.272 | 1 | 0.713 |
KHS2 |
0.819 | 0.082 | 1 | 0.722 |
CLK3 |
0.819 | 0.431 | 1 | 0.837 |
KHS1 |
0.818 | 0.049 | 1 | 0.703 |
ICK |
0.818 | 0.276 | -3 | 0.822 |
TNIK |
0.818 | 0.008 | 3 | 0.851 |
ALK4 |
0.817 | 0.129 | -2 | 0.821 |
EEF2K |
0.816 | 0.020 | 3 | 0.820 |
LRRK2 |
0.816 | -0.106 | 2 | 0.779 |
BRAF |
0.816 | -0.027 | -4 | 0.777 |
NIK |
0.816 | 0.050 | -3 | 0.833 |
CAMLCK |
0.816 | 0.130 | -2 | 0.823 |
MINK |
0.816 | -0.051 | 1 | 0.709 |
HIPK1 |
0.816 | 0.320 | 1 | 0.779 |
ALK2 |
0.815 | 0.192 | -2 | 0.806 |
MAK |
0.815 | 0.338 | -2 | 0.787 |
HPK1 |
0.815 | 0.027 | 1 | 0.723 |
DMPK1 |
0.815 | 0.173 | -3 | 0.802 |
PDK1 |
0.814 | -0.031 | 1 | 0.698 |
DAPK3 |
0.814 | 0.166 | -3 | 0.811 |
TAO3 |
0.814 | 0.031 | 1 | 0.718 |
MST3 |
0.814 | 0.050 | 2 | 0.775 |
CDKL1 |
0.813 | 0.208 | -3 | 0.801 |
JNK3 |
0.813 | 0.242 | 1 | 0.729 |
MAP3K15 |
0.813 | -0.062 | 1 | 0.685 |
P38A |
0.813 | 0.246 | 1 | 0.753 |
NLK |
0.812 | 0.221 | 1 | 0.831 |
VRK1 |
0.812 | -0.177 | 2 | 0.742 |
ASK1 |
0.812 | -0.141 | 1 | 0.670 |
BMPR2 |
0.812 | -0.093 | -2 | 0.830 |
TTK |
0.812 | -0.049 | -2 | 0.778 |
P38B |
0.811 | 0.263 | 1 | 0.708 |
MST2 |
0.811 | -0.094 | 1 | 0.744 |
PRP4 |
0.810 | 0.170 | -3 | 0.711 |
TAO2 |
0.810 | -0.073 | 2 | 0.775 |
MEK1 |
0.810 | -0.152 | 2 | 0.758 |
MPSK1 |
0.810 | 0.076 | 1 | 0.677 |
TGFBR1 |
0.810 | 0.173 | -2 | 0.802 |
SKMLCK |
0.810 | 0.212 | -2 | 0.847 |
NEK1 |
0.810 | -0.133 | 1 | 0.691 |
BMPR1A |
0.809 | 0.256 | 1 | 0.832 |
MEKK2 |
0.809 | -0.118 | 2 | 0.717 |
HGK |
0.809 | -0.053 | 3 | 0.844 |
ROCK2 |
0.809 | 0.147 | -3 | 0.800 |
ALPHAK3 |
0.809 | -0.030 | -1 | 0.686 |
GRK7 |
0.808 | 0.188 | 1 | 0.723 |
CAMK1B |
0.808 | 0.099 | -3 | 0.837 |
MST1 |
0.808 | -0.129 | 1 | 0.713 |
LKB1 |
0.808 | -0.100 | -3 | 0.762 |
OSR1 |
0.807 | -0.056 | 2 | 0.715 |
MEK5 |
0.807 | -0.223 | 2 | 0.746 |
NEK5 |
0.807 | -0.116 | 1 | 0.719 |
MEKK6 |
0.806 | -0.100 | 1 | 0.714 |
PRPK |
0.806 | -0.062 | -1 | 0.771 |
DAPK1 |
0.806 | 0.166 | -3 | 0.797 |
SMMLCK |
0.805 | 0.086 | -3 | 0.810 |
ATR |
0.805 | 0.036 | 1 | 0.750 |
ACVR2B |
0.805 | 0.154 | -2 | 0.767 |
CAMKK2 |
0.805 | -0.141 | -2 | 0.680 |
DLK |
0.805 | -0.090 | 1 | 0.770 |
ANKRD3 |
0.805 | -0.105 | 1 | 0.768 |
DYRK2 |
0.805 | 0.307 | 1 | 0.782 |
MYO3B |
0.803 | -0.065 | 2 | 0.766 |
ACVR2A |
0.803 | 0.122 | -2 | 0.753 |
MYO3A |
0.802 | -0.088 | 1 | 0.703 |
CLK4 |
0.802 | 0.299 | -3 | 0.792 |
NEK11 |
0.802 | -0.155 | 1 | 0.715 |
P38G |
0.802 | 0.246 | 1 | 0.658 |
MOK |
0.801 | 0.266 | 1 | 0.761 |
NEK8 |
0.801 | -0.140 | 2 | 0.747 |
PBK |
0.801 | -0.044 | 1 | 0.663 |
HIPK2 |
0.800 | 0.350 | 1 | 0.712 |
P38D |
0.800 | 0.257 | 1 | 0.664 |
CAMKK1 |
0.799 | -0.191 | -2 | 0.680 |
BIKE |
0.799 | -0.074 | 1 | 0.619 |
YSK1 |
0.799 | -0.101 | 2 | 0.742 |
MEKK1 |
0.799 | -0.175 | 1 | 0.729 |
NEK4 |
0.799 | -0.161 | 1 | 0.693 |
MEKK3 |
0.799 | -0.128 | 1 | 0.734 |
CDK1 |
0.798 | 0.259 | 1 | 0.728 |
HIPK3 |
0.798 | 0.265 | 1 | 0.763 |
CLK2 |
0.797 | 0.387 | -3 | 0.780 |
RAF1 |
0.796 | -0.002 | 1 | 0.773 |
ERK1 |
0.796 | 0.247 | 1 | 0.699 |
PIM1 |
0.796 | 0.177 | -3 | 0.801 |
COT |
0.796 | 0.168 | 2 | 0.782 |
HIPK4 |
0.796 | 0.313 | 1 | 0.802 |
DYRK1A |
0.796 | 0.272 | 1 | 0.778 |
ERK5 |
0.796 | 0.103 | 1 | 0.777 |
YSK4 |
0.795 | -0.134 | 1 | 0.692 |
PIM3 |
0.795 | 0.182 | -3 | 0.824 |
CDKL5 |
0.795 | 0.206 | -3 | 0.795 |
GRK6 |
0.794 | 0.070 | 1 | 0.807 |
LOK |
0.794 | -0.060 | -2 | 0.712 |
CDC7 |
0.794 | 0.214 | 1 | 0.842 |
JNK1 |
0.793 | 0.204 | 1 | 0.700 |
SRPK1 |
0.793 | 0.290 | -3 | 0.776 |
CDK5 |
0.793 | 0.233 | 1 | 0.759 |
ERK2 |
0.793 | 0.180 | 1 | 0.719 |
GRK5 |
0.793 | 0.013 | -3 | 0.770 |
CLK1 |
0.793 | 0.307 | -3 | 0.784 |
ZAK |
0.793 | -0.161 | 1 | 0.713 |
GRK1 |
0.792 | 0.250 | -2 | 0.781 |
CHAK2 |
0.792 | 0.047 | -1 | 0.780 |
AAK1 |
0.792 | -0.020 | 1 | 0.524 |
HASPIN |
0.792 | 0.074 | -1 | 0.685 |
STLK3 |
0.792 | -0.248 | 1 | 0.676 |
TLK2 |
0.791 | -0.024 | 1 | 0.722 |
CDK14 |
0.791 | 0.243 | 1 | 0.719 |
MEK2 |
0.791 | -0.297 | 2 | 0.731 |
DYRK3 |
0.791 | 0.266 | 1 | 0.785 |
CAMK2G |
0.790 | -0.006 | 2 | 0.762 |
MLK2 |
0.790 | -0.120 | 2 | 0.742 |
DYRK4 |
0.790 | 0.295 | 1 | 0.730 |
PKCD |
0.790 | 0.115 | 2 | 0.711 |
ROCK1 |
0.790 | 0.111 | -3 | 0.778 |
PKN3 |
0.790 | 0.061 | -3 | 0.807 |
DYRK1B |
0.789 | 0.251 | 1 | 0.739 |
PLK1 |
0.788 | -0.038 | -2 | 0.746 |
SLK |
0.788 | -0.050 | -2 | 0.670 |
DCAMKL1 |
0.788 | 0.084 | -3 | 0.811 |
WNK1 |
0.788 | 0.045 | -2 | 0.832 |
MRCKB |
0.787 | 0.133 | -3 | 0.770 |
SRPK3 |
0.787 | 0.212 | -3 | 0.743 |
MRCKA |
0.787 | 0.116 | -3 | 0.777 |
MLK1 |
0.787 | -0.070 | 2 | 0.744 |
MST4 |
0.786 | 0.094 | 2 | 0.809 |
PIM2 |
0.786 | 0.127 | -3 | 0.776 |
P70S6KB |
0.786 | 0.121 | -3 | 0.804 |
BUB1 |
0.786 | 0.064 | -5 | 0.716 |
GSK3A |
0.786 | 0.161 | 4 | 0.526 |
PERK |
0.786 | -0.156 | -2 | 0.774 |
TLK1 |
0.785 | -0.098 | -2 | 0.803 |
PDHK3_TYR |
0.785 | 0.310 | 4 | 0.905 |
CDK18 |
0.785 | 0.269 | 1 | 0.687 |
RSK2 |
0.784 | 0.210 | -3 | 0.797 |
SGK3 |
0.784 | 0.142 | -3 | 0.788 |
CRIK |
0.784 | 0.106 | -3 | 0.755 |
CDK17 |
0.784 | 0.237 | 1 | 0.657 |
TAO1 |
0.784 | -0.119 | 1 | 0.641 |
WNK4 |
0.783 | -0.095 | -2 | 0.820 |
PDHK4 |
0.783 | -0.223 | 1 | 0.773 |
GRK2 |
0.783 | 0.021 | -2 | 0.709 |
RIPK3 |
0.783 | -0.015 | 3 | 0.745 |
PKN2 |
0.783 | 0.066 | -3 | 0.826 |
CDK3 |
0.783 | 0.224 | 1 | 0.673 |
AKT2 |
0.782 | 0.168 | -3 | 0.742 |
DSTYK |
0.782 | 0.009 | 2 | 0.812 |
NEK9 |
0.781 | -0.175 | 2 | 0.756 |
MASTL |
0.781 | -0.252 | -2 | 0.753 |
NUAK2 |
0.781 | 0.068 | -3 | 0.837 |
MTOR |
0.781 | 0.027 | 1 | 0.733 |
RIPK1 |
0.781 | -0.147 | 1 | 0.714 |
MLK3 |
0.780 | 0.001 | 2 | 0.679 |
CDK16 |
0.780 | 0.235 | 1 | 0.661 |
DNAPK |
0.780 | 0.005 | 1 | 0.637 |
MYLK4 |
0.780 | 0.116 | -2 | 0.757 |
SGK1 |
0.780 | 0.162 | -3 | 0.677 |
TSSK2 |
0.780 | -0.027 | -5 | 0.786 |
NEK2 |
0.780 | -0.110 | 2 | 0.746 |
CDK4 |
0.780 | 0.200 | 1 | 0.692 |
DRAK1 |
0.780 | 0.001 | 1 | 0.727 |
AMPKA1 |
0.779 | 0.009 | -3 | 0.837 |
CAMK2D |
0.779 | 0.058 | -3 | 0.812 |
CDK6 |
0.779 | 0.187 | 1 | 0.698 |
GSK3B |
0.779 | 0.084 | 4 | 0.519 |
RSK4 |
0.778 | 0.215 | -3 | 0.774 |
TGFBR2 |
0.778 | 0.034 | -2 | 0.778 |
MLK4 |
0.778 | -0.048 | 2 | 0.644 |
CAMK2B |
0.778 | 0.130 | 2 | 0.737 |
PDHK1 |
0.778 | -0.222 | 1 | 0.758 |
CDK10 |
0.778 | 0.255 | 1 | 0.711 |
ERK7 |
0.777 | 0.058 | 2 | 0.502 |
P90RSK |
0.777 | 0.155 | -3 | 0.788 |
CAMK2A |
0.777 | 0.151 | 2 | 0.759 |
DCAMKL2 |
0.776 | 0.004 | -3 | 0.821 |
CDK8 |
0.776 | 0.227 | 1 | 0.747 |
PDHK4_TYR |
0.776 | 0.142 | 2 | 0.817 |
HRI |
0.776 | -0.260 | -2 | 0.786 |
CDK13 |
0.776 | 0.200 | 1 | 0.722 |
CDK7 |
0.776 | 0.212 | 1 | 0.750 |
IRAK4 |
0.776 | -0.144 | 1 | 0.690 |
PKCA |
0.775 | 0.079 | 2 | 0.662 |
CDK12 |
0.775 | 0.208 | 1 | 0.704 |
MAP2K6_TYR |
0.775 | 0.124 | -1 | 0.795 |
PAK1 |
0.774 | 0.093 | -2 | 0.777 |
MAP2K4_TYR |
0.774 | 0.104 | -1 | 0.789 |
PINK1 |
0.774 | -0.126 | 1 | 0.759 |
CHK1 |
0.774 | -0.048 | -3 | 0.789 |
SRPK2 |
0.774 | 0.253 | -3 | 0.715 |
AURB |
0.773 | 0.138 | -2 | 0.666 |
CDK2 |
0.773 | 0.105 | 1 | 0.778 |
PDHK1_TYR |
0.773 | 0.101 | -1 | 0.817 |
ATM |
0.773 | -0.020 | 1 | 0.707 |
TSSK1 |
0.773 | 0.019 | -3 | 0.847 |
PKCZ |
0.772 | 0.021 | 2 | 0.702 |
PKCB |
0.772 | 0.080 | 2 | 0.668 |
TESK1_TYR |
0.772 | 0.021 | 3 | 0.863 |
MSK1 |
0.772 | 0.169 | -3 | 0.759 |
BMPR2_TYR |
0.772 | 0.076 | -1 | 0.801 |
NDR1 |
0.772 | 0.092 | -3 | 0.823 |
MARK4 |
0.772 | -0.036 | 4 | 0.790 |
PKMYT1_TYR |
0.771 | 0.051 | 3 | 0.841 |
NEK7 |
0.771 | -0.109 | -3 | 0.771 |
PKCH |
0.771 | 0.033 | 2 | 0.652 |
AKT1 |
0.771 | 0.146 | -3 | 0.757 |
CHAK1 |
0.770 | -0.129 | 2 | 0.716 |
PAK2 |
0.770 | 0.022 | -2 | 0.758 |
PKACB |
0.770 | 0.208 | -2 | 0.677 |
CHK2 |
0.770 | 0.081 | -3 | 0.705 |
AURA |
0.769 | 0.134 | -2 | 0.651 |
AURC |
0.769 | 0.202 | -2 | 0.673 |
TBK1 |
0.769 | -0.098 | 1 | 0.649 |
NEK6 |
0.769 | -0.024 | -2 | 0.801 |
PKCG |
0.769 | 0.075 | 2 | 0.670 |
PLK3 |
0.768 | -0.121 | 2 | 0.701 |
PKG2 |
0.768 | 0.141 | -2 | 0.673 |
ULK2 |
0.768 | -0.151 | 2 | 0.699 |
PKACG |
0.768 | 0.123 | -2 | 0.729 |
NEK3 |
0.768 | -0.214 | 1 | 0.665 |
SMG1 |
0.768 | -0.063 | 1 | 0.692 |
CDK9 |
0.767 | 0.165 | 1 | 0.727 |
EPHA6 |
0.767 | 0.096 | -1 | 0.785 |
AMPKA2 |
0.767 | 0.018 | -3 | 0.823 |
MAP2K7_TYR |
0.767 | -0.115 | 2 | 0.794 |
PKCE |
0.767 | 0.097 | 2 | 0.658 |
NDR2 |
0.767 | 0.179 | -3 | 0.823 |
LIMK2_TYR |
0.767 | 0.065 | -3 | 0.830 |
HUNK |
0.767 | -0.180 | 2 | 0.706 |
MAPKAPK3 |
0.767 | 0.065 | -3 | 0.784 |
CDK19 |
0.766 | 0.237 | 1 | 0.721 |
PRKD1 |
0.766 | 0.134 | -3 | 0.813 |
CAMK1D |
0.766 | 0.061 | -3 | 0.735 |
IRE1 |
0.766 | -0.080 | 1 | 0.691 |
GRK4 |
0.766 | -0.046 | -2 | 0.796 |
IKKB |
0.764 | -0.026 | -2 | 0.685 |
PRKD3 |
0.764 | 0.087 | -3 | 0.779 |
PAK3 |
0.764 | 0.036 | -2 | 0.763 |
MNK1 |
0.764 | 0.106 | -2 | 0.781 |
WNK3 |
0.764 | -0.221 | 1 | 0.715 |
RSK3 |
0.764 | 0.134 | -3 | 0.782 |
IRE2 |
0.763 | -0.079 | 2 | 0.671 |
LATS2 |
0.763 | 0.094 | -5 | 0.730 |
IKKE |
0.763 | -0.102 | 1 | 0.653 |
CAMK4 |
0.763 | -0.044 | -3 | 0.809 |
SBK |
0.763 | 0.130 | -3 | 0.654 |
MSK2 |
0.762 | 0.110 | -3 | 0.757 |
PRKD2 |
0.762 | 0.154 | -3 | 0.803 |
EPHB4 |
0.762 | 0.038 | -1 | 0.748 |
PINK1_TYR |
0.761 | -0.150 | 1 | 0.745 |
GRK3 |
0.761 | 0.031 | -2 | 0.682 |
TTBK2 |
0.761 | -0.167 | 2 | 0.617 |
TXK |
0.761 | 0.125 | 1 | 0.815 |
PKCI |
0.760 | 0.022 | 2 | 0.675 |
MELK |
0.760 | -0.021 | -3 | 0.810 |
IKKA |
0.760 | 0.040 | -2 | 0.686 |
MAPKAPK2 |
0.760 | 0.132 | -3 | 0.761 |
PLK2 |
0.759 | -0.065 | -3 | 0.656 |
CK1D |
0.759 | 0.047 | -3 | 0.462 |
MNK2 |
0.757 | 0.078 | -2 | 0.772 |
QSK |
0.757 | 0.005 | 4 | 0.762 |
CAMK1G |
0.757 | 0.006 | -3 | 0.778 |
PKACA |
0.757 | 0.171 | -2 | 0.630 |
NIM1 |
0.757 | -0.064 | 3 | 0.753 |
PKCT |
0.756 | 0.023 | 2 | 0.657 |
PRKX |
0.756 | 0.239 | -3 | 0.744 |
EPHA4 |
0.756 | 0.029 | 2 | 0.704 |
CK2A2 |
0.756 | 0.119 | 1 | 0.718 |
KIS |
0.755 | 0.256 | 1 | 0.753 |
QIK |
0.755 | -0.109 | -3 | 0.812 |
LIMK1_TYR |
0.755 | -0.168 | 2 | 0.782 |
RET |
0.755 | -0.151 | 1 | 0.711 |
BLK |
0.754 | 0.073 | -1 | 0.778 |
MARK2 |
0.754 | -0.064 | 4 | 0.677 |
AKT3 |
0.754 | 0.152 | -3 | 0.698 |
SSTK |
0.754 | -0.043 | 4 | 0.757 |
CK1A2 |
0.753 | 0.034 | -3 | 0.469 |
ABL2 |
0.752 | -0.032 | -1 | 0.714 |
STK33 |
0.752 | -0.160 | 2 | 0.540 |
ROS1 |
0.752 | -0.101 | 3 | 0.745 |
SRMS |
0.752 | 0.002 | 1 | 0.814 |
FGR |
0.752 | -0.093 | 1 | 0.754 |
MARK3 |
0.752 | -0.026 | 4 | 0.709 |
YES1 |
0.752 | -0.057 | -1 | 0.778 |
PLK4 |
0.752 | -0.138 | 2 | 0.562 |
TNK2 |
0.751 | -0.006 | 3 | 0.758 |
MST1R |
0.751 | -0.156 | 3 | 0.807 |
LCK |
0.751 | 0.023 | -1 | 0.765 |
P70S6K |
0.751 | 0.050 | -3 | 0.736 |
ULK1 |
0.751 | -0.194 | -3 | 0.718 |
GCN2 |
0.751 | -0.166 | 2 | 0.725 |
IRAK1 |
0.751 | -0.348 | -1 | 0.646 |
EPHB1 |
0.750 | -0.019 | 1 | 0.814 |
TYRO3 |
0.750 | -0.140 | 3 | 0.774 |
JAK2 |
0.750 | -0.150 | 1 | 0.710 |
FER |
0.750 | -0.103 | 1 | 0.816 |
EPHB2 |
0.750 | 0.008 | -1 | 0.730 |
CK1E |
0.750 | 0.048 | -3 | 0.509 |
RIPK2 |
0.749 | -0.298 | 1 | 0.660 |
INSRR |
0.749 | -0.076 | 3 | 0.724 |
MARK1 |
0.749 | -0.082 | 4 | 0.734 |
CAMK1A |
0.749 | 0.046 | -3 | 0.722 |
CK2A1 |
0.749 | 0.109 | 1 | 0.698 |
HCK |
0.749 | -0.054 | -1 | 0.754 |
PHKG1 |
0.749 | -0.015 | -3 | 0.818 |
CSF1R |
0.749 | -0.115 | 3 | 0.773 |
TYK2 |
0.748 | -0.236 | 1 | 0.705 |
ABL1 |
0.748 | -0.058 | -1 | 0.703 |
ITK |
0.748 | -0.027 | -1 | 0.698 |
FYN |
0.748 | 0.031 | -1 | 0.758 |
DDR1 |
0.748 | -0.174 | 4 | 0.809 |
PAK6 |
0.747 | 0.131 | -2 | 0.683 |
BCKDK |
0.747 | -0.186 | -1 | 0.686 |
JAK3 |
0.747 | -0.133 | 1 | 0.692 |
EPHB3 |
0.746 | -0.043 | -1 | 0.725 |
EPHA7 |
0.746 | 0.003 | 2 | 0.696 |
BMX |
0.746 | -0.020 | -1 | 0.637 |
SIK |
0.745 | 0.008 | -3 | 0.778 |
NUAK1 |
0.745 | -0.013 | -3 | 0.797 |
FAM20C |
0.745 | 0.109 | 2 | 0.597 |
YANK3 |
0.745 | -0.058 | 2 | 0.343 |
KDR |
0.745 | -0.096 | 3 | 0.753 |
MET |
0.743 | -0.083 | 3 | 0.778 |
TNNI3K_TYR |
0.742 | -0.060 | 1 | 0.745 |
JAK1 |
0.742 | -0.073 | 1 | 0.659 |
PTK2 |
0.742 | 0.063 | -1 | 0.741 |
MERTK |
0.742 | -0.066 | 3 | 0.766 |
SYK |
0.742 | 0.081 | -1 | 0.717 |
TEC |
0.742 | -0.050 | -1 | 0.637 |
KIT |
0.741 | -0.144 | 3 | 0.774 |
FGFR2 |
0.741 | -0.164 | 3 | 0.786 |
PKN1 |
0.741 | 0.030 | -3 | 0.757 |
TNK1 |
0.741 | -0.094 | 3 | 0.760 |
EPHA3 |
0.738 | -0.108 | 2 | 0.676 |
FLT1 |
0.738 | -0.105 | -1 | 0.750 |
PDGFRB |
0.738 | -0.206 | 3 | 0.786 |
DDR2 |
0.738 | -0.021 | 3 | 0.722 |
PTK2B |
0.737 | -0.020 | -1 | 0.680 |
TEK |
0.737 | -0.153 | 3 | 0.707 |
EPHA5 |
0.737 | -0.018 | 2 | 0.685 |
SNRK |
0.736 | -0.148 | 2 | 0.628 |
FRK |
0.736 | -0.077 | -1 | 0.764 |
NEK10_TYR |
0.736 | -0.166 | 1 | 0.560 |
WEE1_TYR |
0.736 | -0.118 | -1 | 0.636 |
BRSK1 |
0.736 | -0.012 | -3 | 0.799 |
FLT3 |
0.736 | -0.206 | 3 | 0.781 |
AXL |
0.735 | -0.156 | 3 | 0.761 |
EPHA8 |
0.735 | -0.048 | -1 | 0.722 |
MAPKAPK5 |
0.735 | -0.047 | -3 | 0.724 |
FGFR1 |
0.734 | -0.198 | 3 | 0.752 |
ALK |
0.734 | -0.158 | 3 | 0.698 |
LTK |
0.734 | -0.154 | 3 | 0.729 |
FGFR3 |
0.734 | -0.148 | 3 | 0.759 |
LYN |
0.733 | -0.098 | 3 | 0.712 |
TTBK1 |
0.733 | -0.213 | 2 | 0.543 |
EPHA1 |
0.733 | -0.101 | 3 | 0.762 |
ERBB2 |
0.732 | -0.185 | 1 | 0.687 |
SRC |
0.732 | -0.080 | -1 | 0.746 |
NTRK1 |
0.732 | -0.219 | -1 | 0.710 |
PAK5 |
0.732 | 0.075 | -2 | 0.646 |
BTK |
0.731 | -0.214 | -1 | 0.655 |
PTK6 |
0.731 | -0.226 | -1 | 0.605 |
BRSK2 |
0.731 | -0.092 | -3 | 0.807 |
MATK |
0.729 | -0.140 | -1 | 0.647 |
EGFR |
0.728 | -0.105 | 1 | 0.603 |
PDGFRA |
0.728 | -0.289 | 3 | 0.783 |
PHKG2 |
0.728 | -0.030 | -3 | 0.810 |
YANK2 |
0.728 | -0.102 | 2 | 0.354 |
INSR |
0.728 | -0.189 | 3 | 0.707 |
NTRK3 |
0.727 | -0.168 | -1 | 0.664 |
EPHA2 |
0.726 | -0.040 | -1 | 0.690 |
FLT4 |
0.726 | -0.227 | 3 | 0.742 |
ERBB4 |
0.725 | -0.044 | 1 | 0.651 |
NTRK2 |
0.724 | -0.254 | 3 | 0.743 |
CSK |
0.724 | -0.170 | 2 | 0.702 |
PAK4 |
0.724 | 0.085 | -2 | 0.657 |
FGFR4 |
0.722 | -0.135 | -1 | 0.676 |
CK1G1 |
0.716 | -0.009 | -3 | 0.497 |
PKG1 |
0.715 | 0.065 | -2 | 0.595 |
IGF1R |
0.715 | -0.174 | 3 | 0.646 |
ZAP70 |
0.714 | -0.032 | -1 | 0.635 |
CK1G3 |
0.709 | -0.014 | -3 | 0.345 |
FES |
0.708 | -0.133 | -1 | 0.603 |
MUSK |
0.707 | -0.215 | 1 | 0.571 |
CK1G2 |
0.696 | 0.007 | -3 | 0.425 |
CK1A |
0.694 | 0.024 | -3 | 0.383 |