Motif 1187 (n=305)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP55 | UQCRHL | T11 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
| A0A0B4J203 | None | S11 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A1IGU5 | ARHGEF37 | S11 | ochoa | Rho guanine nucleotide exchange factor 37 | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| A2RRP1 | NBAS | S11 | ochoa | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}. |
| A5YM69 | ARHGEF35 | S11 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| B1AHC4 | PRR5-ARHGAP8 | S11 | ochoa | PRR5-ARHGAP8 readthrough | None |
| B5ME19 | EIF3CL | S11 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| C9JAW5 | None | S11 | ochoa | HIG1 domain-containing protein | None |
| J3KQ70 | INO80B-WBP1 | S11 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
| M0R2N4 | None | T11 | ochoa | C3H1-type domain-containing protein | None |
| O00512 | BCL9 | S11 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14682 | ENC1 | S11 | ochoa | Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein) | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}. |
| O14713 | ITGB1BP1 | S11 | ochoa | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O14818 | PSMA7 | S11 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15372 | EIF3H | T11 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43310 | CTIF | S11 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43315 | AQP9 | S11 | psp | Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity). {ECO:0000250|UniProtKB:P56627, ECO:0000250|UniProtKB:Q9JJJ3, ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:26837049, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:35054513, ECO:0000269|PubMed:9514918}. |
| O43526 | KCNQ2 | Y11 | ochoa | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O43609 | SPRY1 | S11 | ochoa | Protein sprouty homolog 1 (Spry-1) | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}. |
| O43707 | ACTN4 | Y11 | psp | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43900 | PRICKLE3 | S11 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
| O60293 | ZFC3H1 | S11 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60508 | CDC40 | S11 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
| O60664 | PLIN3 | S11 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60759 | CYTIP | S11 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
| O60784 | TOM1 | S11 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O60927 | PPP1R11 | T11 | ochoa | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}. |
| O75061 | DNAJC6 | S11 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75182 | SIN3B | S11 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| O75391 | SPAG7 | S11 | ochoa | Sperm-associated antigen 7 | None |
| O75674 | TOM1L1 | Y11 | ochoa | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}. |
| O75821 | EIF3G | S11 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O75822 | EIF3J | S11 | ochoa | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O75909 | CCNK | S11 | ochoa | Cyclin-K | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}. |
| O94888 | UBXN7 | S11 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O95067 | CCNB2 | S11 | ochoa | G2/mitotic-specific cyclin-B2 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| O95863 | SNAI1 | S11 | psp | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| O96011 | PEX11B | S11 | ochoa | Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta) | Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). {ECO:0000269|PubMed:12618434, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670}. |
| O96018 | APBA3 | S11 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) | May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}. |
| O96028 | NSD2 | S11 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00492 | HPRT1 | S11 | ochoa | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| P04553 | PRM1 | S11 | psp | Sperm protamine P1 (Cysteine-rich protamine) | Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. |
| P05109 | S100A8 | S11 | ochoa | Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A) | S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69 (PubMed:26296369). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity. {ECO:0000269|PubMed:12626582, ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:15642721, ECO:0000269|PubMed:16258195, ECO:0000269|PubMed:19087201, ECO:0000269|PubMed:19122197, ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:21487906, ECO:0000269|PubMed:22363402, ECO:0000269|PubMed:22808130, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:26296369}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, may induce expansion of aberrant immature neutrophils in a TLR4-dependent manner. {ECO:0000305|PubMed:33388094}. |
| P05423 | POLR3D | S11 | ochoa | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}. |
| P05771 | PRKCB | S11 | ochoa | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P05783 | KRT18 | T11 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06730 | EIF4E | T11 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07148 | FABP1 | S11 | ochoa | Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP) | Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). {ECO:0000250|UniProtKB:P82289, ECO:0000269|PubMed:25732850}. |
| P07919 | UQCRH | T11 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P07948 | LYN | S11 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08473 | MME | T11 | psp | Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991, PubMed:6349683). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675, PubMed:6349683). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:16254193, PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:2972276, ECO:0000269|PubMed:6208535, ECO:0000269|PubMed:6349683}. |
| P09234 | SNRPC | T11 | ochoa | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}. |
| P10242 | MYB | S11 | psp | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P11233 | RALA | S11 | ochoa | Ras-related protein Ral-A (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:30500825}. |
| P13807 | GYS1 | S11 | ochoa|psp | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P15408 | FOSL2 | T11 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P15882 | CHN1 | Y11 | ochoa | N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
| P15927 | RPA2 | S11 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P16401 | H1-5 | T11 | ochoa|psp | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16989 | YBX3 | T11 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17252 | PRKCA | T11 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P17612 | PRKACA | S11 | psp | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P18754 | RCC1 | S11 | ochoa|psp | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| P20042 | EIF2S2 | T11 | ochoa | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P21333 | FLNA | S11 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22528 | SPRR1B | T11 | ochoa | Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB) | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage. |
| P23443 | RPS6KB1 | Y11 | ochoa | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P25787 | PSMA2 | T11 | ochoa | Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P27707 | DCK | S11 | ochoa|psp | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P27816 | MAP4 | T11 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28347 | TEAD1 | S11 | ochoa | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| P30520 | ADSS2 | S11 | ochoa | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000250|UniProtKB:P46664}. |
| P33908 | MAN1A1 | S11 | ochoa | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). |
| P33992 | MCM5 | Y11 | ochoa | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| P35321 | SPRR1A | T11 | ochoa | Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA) | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. |
| P35579 | MYH9 | Y11 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35611 | ADD1 | T11 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35612 | ADD2 | S11 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P35637 | FUS | T11 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P36578 | RPL4 | Y11 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P37802 | TAGLN2 | S11 | ochoa | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P38435 | GGCX | S11 | ochoa | Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). {ECO:0000269|PubMed:17073445}. |
| P40261 | NNMT | Y11 | ochoa | Nicotinamide N-methyltransferase (EC 2.1.1.1) | Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}. |
| P41743 | PRKCI | S11 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P42677 | RPS27 | S11 | ochoa | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P43243 | MATR3 | S11 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P45973 | CBX5 | S11 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P48029 | SLC6A8 | Y11 | ochoa | Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) | Creatine:sodium symporter which mediates the uptake of creatine (PubMed:17465020, PubMed:22644605, PubMed:25861866, PubMed:7945388, PubMed:7953292, PubMed:9882430). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q8VBW1, ECO:0000269|PubMed:17465020, ECO:0000269|PubMed:22644605, ECO:0000269|PubMed:25861866, ECO:0000269|PubMed:7945388, ECO:0000269|PubMed:7953292, ECO:0000269|PubMed:9882430}. |
| P48651 | PTDSS1 | S11 | ochoa | Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}. |
| P49368 | CCT3 | S11 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51532 | SMARCA4 | T11 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51798 | CLCN7 | S11 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P51965 | UBE2E1 | S11 | ochoa | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050). {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| P52298 | NCBP2 | S11 | ochoa | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17363367, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:26382858}. |
| P52945 | PDX1 | T11 | psp | Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| P53999 | SUB1 | S11 | ochoa | Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275, ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453, ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392, ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}. |
| P54274 | TERF1 | S11 | ochoa | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}. |
| P55055 | NR1H2 | T11 | ochoa | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}. |
| P57086 | SCAND1 | T11 | ochoa | SCAN domain-containing protein 1 | May regulate transcriptional activity. |
| P57740 | NUP107 | S11 | ochoa|psp | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
| P61224 | RAP1B | S11 | ochoa | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}. |
| P61244 | MAX | S11 | ochoa|psp | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P61587 | RND3 | S11 | psp | Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3) | Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. |
| P62136 | PPP1CA | S11 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62310 | LSM3 | T11 | ochoa | U6 snRNA-associated Sm-like protein LSm3 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| P62834 | RAP1A | S11 | ochoa|psp | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:25208567}. |
| P62906 | RPL10A | Y11 | ochoa | Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P78358 | CTAG1A | S11 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
| P81408 | ENTREP3 | S11 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
| P85299 | PRR5 | S11 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| P86452 | ZBED6 | S11 | ochoa | Zinc finger BED domain-containing protein 6 | Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}. |
| Q00341 | HDLBP | S11 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01081 | U2AF1 | T11 | ochoa | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
| Q01995 | TAGLN | S11 | ochoa | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q02535 | ID3 | Y11 | psp | DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}. |
| Q02790 | FKBP4 | S11 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02952 | AKAP12 | S11 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q08117 | TLE5 | S11 | ochoa | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}. |
| Q08495 | DMTN | S11 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q08AM6 | VAC14 | T11 | ochoa | Protein VAC14 homolog (Tax1-binding protein 2) | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}. |
| Q12774 | ARHGEF5 | S11 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12852 | MAP3K12 | S11 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12933 | TRAF2 | S11 | ochoa|psp | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity). {ECO:0000250|UniProtKB:P39429, ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:28489822}. |
| Q13496 | MTM1 | S11 | ochoa | Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}. |
| Q13573 | SNW1 | T11 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13671 | RIN1 | S11 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q13829 | TNFAIP1 | S11 | ochoa | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}. |
| Q14139 | UBE4A | S11 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
| Q14151 | SAFB2 | S11 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14247 | CTTN | S11 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14451 | GRB7 | S11 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14469 | HES1 | S11 | ochoa | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}. |
| Q15003 | NCAPH | T11 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15005 | SPCS2 | S11 | ochoa | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}. |
| Q15072 | ZNF146 | S11 | ochoa | Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) | None |
| Q15078 | CDK5R1 | Y11 | ochoa | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}. |
| Q15208 | STK38 | S11 | psp | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q15311 | RALBP1 | S11 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15424 | SAFB | S11 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15750 | TAB1 | S11 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647, ECO:0000269|PubMed:37832545}. |
| Q15797 | SMAD1 | S11 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q15836 | VAMP3 | S11 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q3YEC7 | RABL6 | S11 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
| Q53ET0 | CRTC2 | S11 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q58EX7 | PLEKHG4 | S11 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5JSH3 | WDR44 | Y11 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5R372 | RABGAP1L | S11 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SZL2 | CEP85L | S11 | ochoa | Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15) | Plays an essential role in neuronal cell migration. {ECO:0000269|PubMed:32097630}. |
| Q658P3 | STEAP3 | S11 | ochoa | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}. |
| Q66K64 | DCAF15 | S11 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q6DN12 | MCTP2 | S11 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6NXE6 | ARMC6 | S11 | ochoa | Armadillo repeat-containing protein 6 | None |
| Q6P1K2 | PMF1 | S11 | ochoa | Polyamine-modulated factor 1 (PMF-1) | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000269|PubMed:10419538, ECO:0000269|PubMed:11256947, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q6UN15 | FIP1L1 | S11 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6ZU65 | UBN2 | S11 | ochoa | Ubinuclein-2 | None |
| Q71UM5 | RPS27L | S11 | ochoa | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | None |
| Q7KZF4 | SND1 | S11 | ochoa | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q7L7V1 | DHX32 | S11 | ochoa | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) | None |
| Q7Z2X7 | PAGE2 | S11 | ochoa | P antigen family member 2 (PAGE-2) (G antigen family C 2) (Prostate-associated gene 2 protein) | None |
| Q7Z434 | MAVS | Y11 | psp | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5U6 | WDR53 | S11 | ochoa | WD repeat-containing protein 53 | None |
| Q86US8 | SMG6 | S11 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UW7 | CADPS2 | S11 | ochoa | Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}. |
| Q86UX6 | STK32C | S11 | ochoa | Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) | None |
| Q86UX7 | FERMT3 | Y11 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86VP1 | TAX1BP1 | T11 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VZ4 | LRP11 | S11 | ochoa | Low-density lipoprotein receptor-related protein 11 (LRP-11) | None |
| Q86W47 | KCNMB4 | T11 | psp | Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Hbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4) | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}. |
| Q86WR7 | PROSER2 | S11 | ochoa | Proline and serine-rich protein 2 | None |
| Q8IVP5 | FUNDC1 | Y11 | ochoa | FUN14 domain-containing protein 1 | Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:33972548). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels (PubMed:33972548). Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria (PubMed:22267086, PubMed:24671035, PubMed:24746696, PubMed:27653272). Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia (PubMed:27145933, PubMed:33978709). Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy (PubMed:36828120). {ECO:0000269|PubMed:22267086, ECO:0000269|PubMed:24671035, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27653272, ECO:0000269|PubMed:33972548, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:36828120}. |
| Q8IWB7 | WDFY1 | S11 | ochoa | WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17) | Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). {ECO:0000269|PubMed:25736436}. |
| Q8IWJ2 | GCC2 | S11 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IWZ3 | ANKHD1 | S11 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IY95 | TMEM192 | S11 | ochoa | Transmembrane protein 192 | None |
| Q8N2H9 | PELI3 | S11 | ochoa | E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12874243). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 (PubMed:12874243). Can activate AP1/JUN and ELK1 (PubMed:12874243). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity). {ECO:0000250|UniProtKB:Q8BXR6, ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}. |
| Q8N302 | AGGF1 | S11 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N344 | MIER2 | S11 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N3R9 | PALS1 | T11 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N554 | ZNF276 | S11 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8NAV1 | PRPF38A | S11 | ochoa | Pre-mRNA-splicing factor 38A | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:26673105, ECO:0000269|PubMed:28781166}. |
| Q8NAX2 | KDF1 | S11 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
| Q8NCN4 | RNF169 | S11 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8ND76 | CCNY | S11 | ochoa | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NEL9 | DDHD1 | S11 | ochoa|psp | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NFW9 | MYRIP | T11 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8NFY9 | KBTBD8 | S11 | ochoa | Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}. |
| Q8TAA9 | VANGL1 | S11 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TAT6 | NPLOC4 | S11 | ochoa | Nuclear protein localization protein 4 homolog (Protein NPL4) | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}. |
| Q8TB36 | GDAP1 | S11 | ochoa | Ganglioside-induced differentiation-associated protein 1 (GDAP1) | Regulates the mitochondrial network by promoting mitochondrial fission. {ECO:0000269|PubMed:16172208}. |
| Q8TBP0 | TBC1D16 | S11 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TC26 | TMEM163 | S11 | ochoa | Transmembrane protein 163 | Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}. |
| Q8TEB1 | DCAF11 | S11 | ochoa | DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q8WU68 | U2AF1L4 | T11 | ochoa | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Q8WUN7 | UBTD2 | S11 | ochoa | Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72) | None |
| Q8WWH5 | TRUB1 | S11 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WYL5 | SSH1 | T11 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q96AE4 | FUBP1 | S11 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96BT3 | CENPT | T11 | ochoa|psp | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96C19 | EFHD2 | S11 | ochoa | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96C24 | SYTL4 | S11 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96C55 | ZNF524 | S11 | ochoa | Zinc finger protein 524 | May be involved in transcriptional regulation. |
| Q96CP6 | GRAMD1A | S11 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96D46 | NMD3 | S11 | ochoa | 60S ribosomal export protein NMD3 (hNMD3) | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. |
| Q96EV8 | DTNBP1 | S11 | ochoa | Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}. |
| Q96EZ8 | MCRS1 | S11 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96FZ5 | CMTM7 | T11 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
| Q96GM8 | TOE1 | S11 | ochoa | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q96KB5 | PBK | S11 | ochoa | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q96LR5 | UBE2E2 | S11 | ochoa | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:9371400}. |
| Q96MF7 | NSMCE2 | S11 | ochoa | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785). {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:31400850}. |
| Q96S97 | MYADM | T11 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q96SB8 | SMC6 | S11 | ochoa | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:26983541}. |
| Q99439 | CNN2 | S11 | ochoa | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99501 | GAS2L1 | S11 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99594 | TEAD3 | S11 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99613 | EIF3C | S11 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99717 | SMAD5 | T11 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q99767 | APBA2 | S11 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q99848 | EBNA1BP2 | S11 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q9BQF6 | SENP7 | S11 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BQG0 | MYBBP1A | S11 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BR01 | SULT4A1 | T11 | psp | Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) | Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269|PubMed:17425406}. |
| Q9BSB4 | ATG101 | S11 | psp | Autophagy-related protein 101 | Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. {ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:19597335}. |
| Q9BSJ6 | PIMREG | S11 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BTX7 | TTPAL | S11 | ochoa | Alpha-tocopherol transfer protein-like | May act as a protein that binds a hydrophobic ligand. {ECO:0000305}. |
| Q9BYG5 | PARD6B | S11 | ochoa | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
| Q9C005 | DPY30 | T11 | ochoa | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| Q9C086 | INO80B | S11 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
| Q9H089 | LSG1 | S11 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H0H3 | KLHL25 | S11 | ochoa | Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}. |
| Q9H0S4 | DDX47 | T11 | ochoa | Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) | Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068). {ECO:0000250|UniProtKB:Q9VIF6, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}. |
| Q9H0U9 | TSPYL1 | T11 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
| Q9H2H9 | SLC38A1 | T11 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2Y7 | ZNF106 | S11 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H3Q1 | CDC42EP4 | S11 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H3Z4 | DNAJC5 | T11 | ochoa | DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}. |
| Q9H4A3 | WNK1 | S11 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H714 | RUBCNL | S11 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9H8T0 | AKTIP | S11 | ochoa | AKT-interacting protein (Ft1) (Fused toes protein homolog) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9H8V3 | ECT2 | T11 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9C1 | VIPAS39 | Y11 | psp | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9H9E3 | COG4 | S11 | ochoa | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) | Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}. |
| Q9HA47 | UCK1 | S11 | ochoa | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
| Q9HC35 | EML4 | S11 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCD5 | NCOA5 | T11 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NQC1 | JADE2 | S11 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NQC3 | RTN4 | S11 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQT5 | EXOSC3 | S11 | ochoa | Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:21255825}. |
| Q9NR33 | POLE4 | T11 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
| Q9NRA8 | EIF4ENIF1 | S11 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NS39 | ADARB2 | S11 | ochoa | Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) | Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA. |
| Q9NS73 | MBIP | S11 | ochoa | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}. |
| Q9NWK9 | ZNHIT6 | S11 | ochoa | Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) | Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. {ECO:0000269|PubMed:17636026}. |
| Q9NX63 | CHCHD3 | T11 | psp | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NX76 | CMTM6 | T11 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9NXH3 | PPP1R14D | S11 | ochoa | Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) | Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}. |
| Q9P0K7 | RAI14 | S11 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0K8 | FOXJ2 | S11 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
| Q9P0V3 | SH3BP4 | S11 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P1Z2 | CALCOCO1 | S11 | ochoa | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Q9P215 | POGK | S11 | ochoa | Pogo transposable element with KRAB domain | None |
| Q9P253 | VPS18 | S11 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9UBS0 | RPS6KB2 | T11 | ochoa | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q9UEY8 | ADD3 | T11 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UH99 | SUN2 | Y11 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UHV9 | PFDN2 | S11 | ochoa | Prefoldin subunit 2 | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9UHY1 | NRBP1 | S11 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UJ55 | MAGEL2 | S11 | ochoa | MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) | Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity). {ECO:0000250|UniProtKB:Q9QZ04, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:23452853}. |
| Q9UJF2 | RASAL2 | S11 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK45 | LSM7 | S11 | ochoa | U6 snRNA-associated Sm-like protein LSm7 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| Q9UKS7 | IKZF2 | T11 | ochoa | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}. |
| Q9UM01 | SLC7A7 | S11 | ochoa | Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}. |
| Q9UNL2 | SSR3 | S11 | ochoa | Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. |
| Q9UQ80 | PA2G4 | T11 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y241 | HIGD1A | S11 | ochoa | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9Y2J2 | EPB41L3 | S11 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2Z0 | SUGT1 | S11 | ochoa | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y3B9 | RRP15 | S11 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y3C0 | WASHC3 | S11 | ochoa | WASH complex subunit 3 (Coiled-coil domain-containing protein 53) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093}. |
| Q9Y6J0 | CABIN1 | S11 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6M1 | IGF2BP2 | S11 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| U3KQ54 | PMF1-BGLAP | S11 | ochoa | HCG2044777 (PMF1-BGLAP readthrough) | None |
| P25786 | PSMA1 | T11 | Sugiyama | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P21108 | PRPS1L1 | S11 | Sugiyama | Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| P60891 | PRPS1 | S11 | Sugiyama | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| O75083 | WDR1 | S11 | Sugiyama | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| P68431 | H3C1 | S11 | GPS6|SIGNOR|ELM|EPSD | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P83731 | RPL24 | Y11 | Sugiyama | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q9BZZ5 | API5 | Y11 | Sugiyama | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}. |
| P84243 | H3-3A | S11 | GPS6|SIGNOR | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q16695 | H3-4 | S11 | SIGNOR|iPTMNet|EPSD | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q71DI3 | H3C15 | S11 | GPS6 | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8N5M4 | TTC9C | Y11 | Sugiyama | Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) | None |
| P55769 | SNU13 | Y11 | Sugiyama | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O60941 | DTNB | T11 | EPSD|PSP | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| P09497 | CLTB | S11 | SIGNOR|iPTMNet | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| Q00688 | FKBP3 | T11 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| O94776 | MTA2 | Y11 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q13330 | MTA1 | Y11 | Sugiyama | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q9BTC8 | MTA3 | Y11 | Sugiyama | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| P37108 | SRP14 | T11 | Sugiyama | Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:11089964). {ECO:0000269|PubMed:11089964}. |
| Q13237 | PRKG2 | S11 | Sugiyama | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| P49792 | RANBP2 | Y11 | Sugiyama | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| Q14524 | SCN5A | S11 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q7Z7L9 | ZSCAN2 | T11 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.000013 | 4.897 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.000013 | 4.897 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.000028 | 4.560 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.000028 | 4.560 |
| R-HSA-72649 | Translation initiation complex formation | 0.000064 | 4.196 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.000068 | 4.170 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.000079 | 4.102 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.000098 | 4.011 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.000107 | 3.971 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.000120 | 3.923 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000159 | 3.797 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.000177 | 3.752 |
| R-HSA-1640170 | Cell Cycle | 0.000208 | 3.681 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.000325 | 3.488 |
| R-HSA-68886 | M Phase | 0.000446 | 3.350 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.000554 | 3.257 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000582 | 3.235 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000757 | 3.121 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.000781 | 3.107 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.000870 | 3.060 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000894 | 3.048 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.001049 | 2.979 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.001116 | 2.952 |
| R-HSA-69306 | DNA Replication | 0.001207 | 2.918 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.001515 | 2.820 |
| R-HSA-2262752 | Cellular responses to stress | 0.001435 | 2.843 |
| R-HSA-392517 | Rap1 signalling | 0.001814 | 2.741 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.001743 | 2.759 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.001764 | 2.754 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.001817 | 2.741 |
| R-HSA-432030 | Transport of glycerol from adipocytes to the liver by Aquaporins | 0.001918 | 2.717 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.001947 | 2.711 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.002030 | 2.693 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.002103 | 2.677 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.002289 | 2.640 |
| R-HSA-163560 | Triglyceride catabolism | 0.002386 | 2.622 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.002356 | 2.628 |
| R-HSA-68875 | Mitotic Prophase | 0.002476 | 2.606 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.002605 | 2.584 |
| R-HSA-8953854 | Metabolism of RNA | 0.002712 | 2.567 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002733 | 2.563 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.003177 | 2.498 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.003479 | 2.459 |
| R-HSA-195721 | Signaling by WNT | 0.003590 | 2.445 |
| R-HSA-72766 | Translation | 0.003755 | 2.425 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.003731 | 2.428 |
| R-HSA-1500620 | Meiosis | 0.003982 | 2.400 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.004142 | 2.383 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.004142 | 2.383 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.004142 | 2.383 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.004965 | 2.304 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.004947 | 2.306 |
| R-HSA-446728 | Cell junction organization | 0.004988 | 2.302 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.005347 | 2.272 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.005347 | 2.272 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.005276 | 2.278 |
| R-HSA-421270 | Cell-cell junction organization | 0.005666 | 2.247 |
| R-HSA-1500931 | Cell-Cell communication | 0.005867 | 2.232 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.006164 | 2.210 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.006266 | 2.203 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.006752 | 2.171 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.007020 | 2.154 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.007547 | 2.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.007627 | 2.118 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.008041 | 2.095 |
| R-HSA-72172 | mRNA Splicing | 0.008923 | 2.049 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008618 | 2.065 |
| R-HSA-912446 | Meiotic recombination | 0.008855 | 2.053 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.008507 | 2.070 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.008456 | 2.073 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.008456 | 2.073 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.008890 | 2.051 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.010394 | 1.983 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.009901 | 2.004 |
| R-HSA-72187 | mRNA 3'-end processing | 0.009471 | 2.024 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.010115 | 1.995 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.009118 | 2.040 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.009118 | 2.040 |
| R-HSA-4086400 | PCP/CE pathway | 0.010568 | 1.976 |
| R-HSA-162582 | Signal Transduction | 0.010389 | 1.983 |
| R-HSA-9675108 | Nervous system development | 0.009983 | 2.001 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.009498 | 2.022 |
| R-HSA-69206 | G1/S Transition | 0.010624 | 1.974 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.010779 | 1.967 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.010779 | 1.967 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.011493 | 1.940 |
| R-HSA-69481 | G2/M Checkpoints | 0.011487 | 1.940 |
| R-HSA-73887 | Death Receptor Signaling | 0.011826 | 1.927 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.011727 | 1.931 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.011966 | 1.922 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.012727 | 1.895 |
| R-HSA-4839726 | Chromatin organization | 0.013040 | 1.885 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.012727 | 1.895 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.013684 | 1.864 |
| R-HSA-68882 | Mitotic Anaphase | 0.012737 | 1.895 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.013103 | 1.883 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.012994 | 1.886 |
| R-HSA-8853659 | RET signaling | 0.013712 | 1.863 |
| R-HSA-69239 | Synthesis of DNA | 0.014176 | 1.848 |
| R-HSA-186712 | Regulation of beta-cell development | 0.014621 | 1.835 |
| R-HSA-8979227 | Triglyceride metabolism | 0.014621 | 1.835 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.014914 | 1.826 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.015484 | 1.810 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.015887 | 1.799 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.016380 | 1.786 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.016448 | 1.784 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.017223 | 1.764 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.017311 | 1.762 |
| R-HSA-156902 | Peptide chain elongation | 0.018017 | 1.744 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.018272 | 1.738 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.018346 | 1.736 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.018346 | 1.736 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.018346 | 1.736 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.019346 | 1.713 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.020549 | 1.687 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.019639 | 1.707 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.020822 | 1.681 |
| R-HSA-422475 | Axon guidance | 0.018567 | 1.731 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.020308 | 1.692 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.021633 | 1.665 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.022364 | 1.650 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.022389 | 1.650 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.023089 | 1.637 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.023089 | 1.637 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.023089 | 1.637 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.023627 | 1.627 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 0.027103 | 1.567 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.028564 | 1.544 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.025285 | 1.597 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.028564 | 1.544 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.027277 | 1.564 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.026312 | 1.580 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.025363 | 1.596 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.028569 | 1.544 |
| R-HSA-69242 | S Phase | 0.026231 | 1.581 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.028569 | 1.544 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.026410 | 1.578 |
| R-HSA-420029 | Tight junction interactions | 0.028701 | 1.542 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.028701 | 1.542 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.029899 | 1.524 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.030250 | 1.519 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.030250 | 1.519 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.031376 | 1.503 |
| R-HSA-192823 | Viral mRNA Translation | 0.035538 | 1.449 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.031866 | 1.497 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.033587 | 1.474 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.033061 | 1.481 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.032282 | 1.491 |
| R-HSA-5689603 | UCH proteinases | 0.034120 | 1.467 |
| R-HSA-9711097 | Cellular response to starvation | 0.035145 | 1.454 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.033061 | 1.481 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.031376 | 1.503 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.034585 | 1.461 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.031994 | 1.495 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.030699 | 1.513 |
| R-HSA-418990 | Adherens junctions interactions | 0.031661 | 1.499 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.035656 | 1.448 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.035895 | 1.445 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.041351 | 1.384 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.041351 | 1.384 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.041351 | 1.384 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.041351 | 1.384 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 0.041351 | 1.384 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.041351 | 1.384 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.041351 | 1.384 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.040648 | 1.391 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.040648 | 1.391 |
| R-HSA-5334118 | DNA methylation | 0.038878 | 1.410 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.039550 | 1.403 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.039550 | 1.403 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.041584 | 1.381 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.041584 | 1.381 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.040648 | 1.391 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.040298 | 1.395 |
| R-HSA-68877 | Mitotic Prometaphase | 0.038107 | 1.419 |
| R-HSA-180024 | DARPP-32 events | 0.038878 | 1.410 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.039550 | 1.403 |
| R-HSA-72312 | rRNA processing | 0.043674 | 1.360 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.037574 | 1.425 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.041672 | 1.380 |
| R-HSA-1474165 | Reproduction | 0.037125 | 1.430 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.040648 | 1.391 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.043677 | 1.360 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.044565 | 1.351 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.045109 | 1.346 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.045133 | 1.346 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.045623 | 1.341 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.045671 | 1.340 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.050809 | 1.294 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.050809 | 1.294 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.056195 | 1.250 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.045828 | 1.339 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.048037 | 1.318 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.050761 | 1.294 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.050761 | 1.294 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.055011 | 1.260 |
| R-HSA-418457 | cGMP effects | 0.056195 | 1.250 |
| R-HSA-9930044 | Nuclear RNA decay | 0.050641 | 1.295 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.050809 | 1.294 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.057097 | 1.243 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.056195 | 1.250 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.056195 | 1.250 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.056195 | 1.250 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.056536 | 1.248 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.057097 | 1.243 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.047555 | 1.323 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.050154 | 1.300 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.053822 | 1.269 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.057097 | 1.243 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.057097 | 1.243 |
| R-HSA-157118 | Signaling by NOTCH | 0.051775 | 1.286 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.050641 | 1.295 |
| R-HSA-1266738 | Developmental Biology | 0.053082 | 1.275 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.048037 | 1.318 |
| R-HSA-8963896 | HDL assembly | 0.056195 | 1.250 |
| R-HSA-6807070 | PTEN Regulation | 0.049690 | 1.304 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.048917 | 1.311 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.057451 | 1.241 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.058542 | 1.233 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.061383 | 1.212 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.061770 | 1.209 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.061770 | 1.209 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.067525 | 1.171 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.073448 | 1.134 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.073448 | 1.134 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.060464 | 1.219 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.063922 | 1.194 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.070503 | 1.152 |
| R-HSA-73886 | Chromosome Maintenance | 0.068772 | 1.163 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.073448 | 1.134 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.060464 | 1.219 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.073448 | 1.134 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.067469 | 1.171 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.067525 | 1.171 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.067469 | 1.171 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.067525 | 1.171 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.059949 | 1.222 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.068772 | 1.163 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.062503 | 1.204 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.073448 | 1.134 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.060464 | 1.219 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.060464 | 1.219 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.078633 | 1.104 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.071105 | 1.148 |
| R-HSA-4641258 | Degradation of DVL | 0.067469 | 1.171 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.074826 | 1.126 |
| R-HSA-111933 | Calmodulin induced events | 0.063922 | 1.194 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.067525 | 1.171 |
| R-HSA-111997 | CaM pathway | 0.063922 | 1.194 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.063922 | 1.194 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.063922 | 1.194 |
| R-HSA-4641257 | Degradation of AXIN | 0.067469 | 1.171 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.067469 | 1.171 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.074826 | 1.126 |
| R-HSA-169911 | Regulation of Apoptosis | 0.060464 | 1.219 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.062503 | 1.204 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.062674 | 1.203 |
| R-HSA-2559583 | Cellular Senescence | 0.062866 | 1.202 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.078633 | 1.104 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.062503 | 1.204 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.074619 | 1.127 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.074826 | 1.126 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.074840 | 1.126 |
| R-HSA-168255 | Influenza Infection | 0.061441 | 1.212 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.078633 | 1.104 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.062503 | 1.204 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.059949 | 1.222 |
| R-HSA-9758941 | Gastrulation | 0.066303 | 1.178 |
| R-HSA-69541 | Stabilization of p53 | 0.074826 | 1.126 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.079532 | 1.099 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.079532 | 1.099 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.079532 | 1.099 |
| R-HSA-157579 | Telomere Maintenance | 0.080800 | 1.093 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 0.080998 | 1.092 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 0.080998 | 1.092 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.082522 | 1.083 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.082522 | 1.083 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.082522 | 1.083 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.082522 | 1.083 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.082522 | 1.083 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.082522 | 1.083 |
| R-HSA-114608 | Platelet degranulation | 0.082843 | 1.082 |
| R-HSA-74160 | Gene expression (Transcription) | 0.083702 | 1.077 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.100204 | 0.999 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.100204 | 0.999 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.100204 | 0.999 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 0.100204 | 0.999 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.100204 | 0.999 |
| R-HSA-9673240 | Defective gamma-carboxylation of F9 | 0.100204 | 0.999 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.119009 | 0.924 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.119009 | 0.924 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.137423 | 0.862 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.173107 | 0.762 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.190393 | 0.720 |
| R-HSA-964827 | Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t... | 0.190393 | 0.720 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.190393 | 0.720 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.190393 | 0.720 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 0.190393 | 0.720 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.190393 | 0.720 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.207319 | 0.683 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.207319 | 0.683 |
| R-HSA-196025 | Formation of annular gap junctions | 0.207319 | 0.683 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.085766 | 1.067 |
| R-HSA-9613354 | Lipophagy | 0.223892 | 0.650 |
| R-HSA-190873 | Gap junction degradation | 0.223892 | 0.650 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.223892 | 0.650 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.223892 | 0.650 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.098651 | 1.006 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.240119 | 0.620 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.240119 | 0.620 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.112034 | 0.951 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.125855 | 0.900 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.132910 | 0.876 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.154573 | 0.811 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.154573 | 0.811 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.154573 | 0.811 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.154573 | 0.811 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.169366 | 0.771 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.176849 | 0.752 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.184384 | 0.734 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.184384 | 0.734 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.184384 | 0.734 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.199583 | 0.700 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.214923 | 0.668 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.214923 | 0.668 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.223092 | 0.652 |
| R-HSA-354192 | Integrin signaling | 0.199583 | 0.700 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.169366 | 0.771 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.118894 | 0.925 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.091085 | 1.041 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.240119 | 0.620 |
| R-HSA-73893 | DNA Damage Bypass | 0.120966 | 0.917 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.159234 | 0.798 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.132910 | 0.876 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.132910 | 0.876 |
| R-HSA-3214842 | HDMs demethylate histones | 0.140052 | 0.854 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.140052 | 0.854 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.140052 | 0.854 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.092142 | 1.036 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.087985 | 1.056 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.087985 | 1.056 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.120966 | 0.917 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.231206 | 0.636 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.231206 | 0.636 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.147275 | 0.832 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.085766 | 1.067 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.199583 | 0.700 |
| R-HSA-1221632 | Meiotic synapsis | 0.139814 | 0.854 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.238116 | 0.623 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.192180 | 0.716 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.191963 | 0.717 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.191963 | 0.717 |
| R-HSA-3214847 | HATs acetylate histones | 0.085725 | 1.067 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.249272 | 0.603 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.105284 | 0.978 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.174915 | 0.757 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.174915 | 0.757 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.174915 | 0.757 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.174915 | 0.757 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.183488 | 0.736 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.094670 | 1.024 |
| R-HSA-75893 | TNF signaling | 0.154554 | 0.811 |
| R-HSA-9907900 | Proteasome assembly | 0.098874 | 1.005 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.135838 | 0.867 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.184384 | 0.734 |
| R-HSA-201451 | Signaling by BMP | 0.154573 | 0.811 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.119009 | 0.924 |
| R-HSA-1483101 | Synthesis of PS | 0.155453 | 0.808 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.173107 | 0.762 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.190393 | 0.720 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.207319 | 0.683 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.207319 | 0.683 |
| R-HSA-163615 | PKA activation | 0.085766 | 1.067 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.085766 | 1.067 |
| R-HSA-170984 | ARMS-mediated activation | 0.223892 | 0.650 |
| R-HSA-176974 | Unwinding of DNA | 0.223892 | 0.650 |
| R-HSA-68952 | DNA replication initiation | 0.240119 | 0.620 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.240119 | 0.620 |
| R-HSA-9865881 | Complex III assembly | 0.132910 | 0.876 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.132910 | 0.876 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.184384 | 0.734 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.238116 | 0.623 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.166262 | 0.779 |
| R-HSA-8951664 | Neddylation | 0.141213 | 0.850 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.142011 | 0.848 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.140052 | 0.854 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.169366 | 0.771 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.169366 | 0.771 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.235692 | 0.628 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.235692 | 0.628 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.223892 | 0.650 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 0.240119 | 0.620 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.207238 | 0.684 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.132120 | 0.879 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.223892 | 0.650 |
| R-HSA-187687 | Signalling to ERKs | 0.222634 | 0.652 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.124815 | 0.904 |
| R-HSA-3371556 | Cellular response to heat stress | 0.159485 | 0.797 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 0.190393 | 0.720 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.207319 | 0.683 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.207319 | 0.683 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.207319 | 0.683 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.207319 | 0.683 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.085766 | 1.067 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.240119 | 0.620 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.240119 | 0.620 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.140052 | 0.854 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.086492 | 1.063 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.090542 | 1.043 |
| R-HSA-9710421 | Defective pyroptosis | 0.094670 | 1.024 |
| R-HSA-69190 | DNA strand elongation | 0.191963 | 0.717 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.214923 | 0.668 |
| R-HSA-191859 | snRNP Assembly | 0.169755 | 0.770 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.169755 | 0.770 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.147275 | 0.832 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.100692 | 0.997 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.174915 | 0.757 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.128446 | 0.891 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.147275 | 0.832 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.217606 | 0.662 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.217881 | 0.662 |
| R-HSA-381042 | PERK regulates gene expression | 0.222634 | 0.652 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.107928 | 0.967 |
| R-HSA-9843745 | Adipogenesis | 0.201748 | 0.695 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.237878 | 0.624 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.173107 | 0.762 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.223892 | 0.650 |
| R-HSA-9668250 | Defective factor IX causes hemophilia B | 0.240119 | 0.620 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.154573 | 0.811 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.230366 | 0.638 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.088245 | 1.054 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.250893 | 0.601 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.112619 | 0.948 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.251207 | 0.600 |
| R-HSA-111996 | Ca-dependent events | 0.090542 | 1.043 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.199583 | 0.700 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.207238 | 0.684 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.238116 | 0.623 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.103152 | 0.987 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.103152 | 0.987 |
| R-HSA-73927 | Depurination | 0.245878 | 0.609 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.239704 | 0.620 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.157622 | 0.802 |
| R-HSA-8964011 | HDL clearance | 0.173107 | 0.762 |
| R-HSA-73614 | Pyrimidine salvage | 0.161938 | 0.791 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.191963 | 0.717 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.084937 | 1.071 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.199583 | 0.700 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.135012 | 0.870 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.207238 | 0.684 |
| R-HSA-112043 | PLC beta mediated events | 0.180118 | 0.744 |
| R-HSA-422356 | Regulation of insulin secretion | 0.200460 | 0.698 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.249272 | 0.603 |
| R-HSA-8956321 | Nucleotide salvage | 0.180118 | 0.744 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.084975 | 1.071 |
| R-HSA-111885 | Opioid Signalling | 0.226742 | 0.644 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.223892 | 0.650 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.240119 | 0.620 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.207238 | 0.684 |
| R-HSA-74217 | Purine salvage | 0.245878 | 0.609 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.149587 | 0.825 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.135012 | 0.870 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.084937 | 1.071 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.222447 | 0.653 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.127420 | 0.895 |
| R-HSA-112040 | G-protein mediated events | 0.212150 | 0.673 |
| R-HSA-162906 | HIV Infection | 0.155224 | 0.809 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.223892 | 0.650 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.240119 | 0.620 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.094670 | 1.024 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.098874 | 1.005 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.103152 | 0.987 |
| R-HSA-3371511 | HSF1 activation | 0.230366 | 0.638 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.244726 | 0.611 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.244726 | 0.611 |
| R-HSA-109582 | Hemostasis | 0.132590 | 0.877 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.231805 | 0.635 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.085766 | 1.067 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.191915 | 0.717 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.110655 | 0.956 |
| R-HSA-70171 | Glycolysis | 0.209118 | 0.680 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.153394 | 0.814 |
| R-HSA-5688426 | Deubiquitination | 0.131601 | 0.881 |
| R-HSA-166520 | Signaling by NTRKs | 0.142011 | 0.848 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.154573 | 0.811 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.103152 | 0.987 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.091085 | 1.041 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.230366 | 0.638 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.175260 | 0.756 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.154573 | 0.811 |
| R-HSA-73884 | Base Excision Repair | 0.158997 | 0.799 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.085526 | 1.068 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.223892 | 0.650 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.125855 | 0.900 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.103152 | 0.987 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.091085 | 1.041 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.240199 | 0.619 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.180118 | 0.744 |
| R-HSA-9909396 | Circadian clock | 0.096083 | 1.017 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.223892 | 0.650 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.240119 | 0.620 |
| R-HSA-9766229 | Degradation of CDH1 | 0.120966 | 0.917 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.119667 | 0.922 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.103152 | 0.987 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.103152 | 0.987 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.214923 | 0.668 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.128446 | 0.891 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.093765 | 1.028 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.084937 | 1.071 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.152824 | 0.816 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.214923 | 0.668 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.130268 | 0.885 |
| R-HSA-8875878 | MET promotes cell motility | 0.245878 | 0.609 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.225016 | 0.648 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.139814 | 0.854 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.139867 | 0.854 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.209118 | 0.680 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.223892 | 0.650 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.238116 | 0.623 |
| R-HSA-194138 | Signaling by VEGF | 0.176636 | 0.753 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.150511 | 0.822 |
| R-HSA-5357801 | Programmed Cell Death | 0.201122 | 0.697 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.130268 | 0.885 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.110746 | 0.956 |
| R-HSA-109581 | Apoptosis | 0.089784 | 1.047 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.159572 | 0.797 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.190649 | 0.720 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.094236 | 1.026 |
| R-HSA-351202 | Metabolism of polyamines | 0.174915 | 0.757 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.087715 | 1.057 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.234142 | 0.631 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.132910 | 0.876 |
| R-HSA-9824272 | Somitogenesis | 0.103152 | 0.987 |
| R-HSA-211000 | Gene Silencing by RNA | 0.109764 | 0.960 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.214923 | 0.668 |
| R-HSA-449147 | Signaling by Interleukins | 0.209747 | 0.678 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.120966 | 0.917 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.120966 | 0.917 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.171088 | 0.767 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.253650 | 0.596 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.253650 | 0.596 |
| R-HSA-71336 | Pentose phosphate pathway | 0.253650 | 0.596 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.253650 | 0.596 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.253650 | 0.596 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.253836 | 0.595 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.256008 | 0.592 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.256008 | 0.592 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.256008 | 0.592 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.256008 | 0.592 |
| R-HSA-210990 | PECAM1 interactions | 0.256008 | 0.592 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.256008 | 0.592 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.258417 | 0.588 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.258417 | 0.588 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.259081 | 0.587 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.261427 | 0.583 |
| R-HSA-3371568 | Attenuation phase | 0.261427 | 0.583 |
| R-HSA-5260271 | Diseases of Immune System | 0.261427 | 0.583 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.261427 | 0.583 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.261427 | 0.583 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.262157 | 0.581 |
| R-HSA-69275 | G2/M Transition | 0.267343 | 0.573 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.268469 | 0.571 |
| R-HSA-212436 | Generic Transcription Pathway | 0.268895 | 0.570 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.269206 | 0.570 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.269206 | 0.570 |
| R-HSA-159740 | Gamma-carboxylation of protein precursors | 0.271566 | 0.566 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.271566 | 0.566 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.272256 | 0.565 |
| R-HSA-5619084 | ABC transporter disorders | 0.273483 | 0.563 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.274451 | 0.562 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.276897 | 0.558 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.276983 | 0.558 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.276983 | 0.558 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.276983 | 0.558 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.276983 | 0.558 |
| R-HSA-9659379 | Sensory processing of sound | 0.279166 | 0.554 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.283035 | 0.548 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.284755 | 0.546 |
| R-HSA-165159 | MTOR signalling | 0.284755 | 0.546 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.284755 | 0.546 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.284755 | 0.546 |
| R-HSA-73928 | Depyrimidination | 0.284755 | 0.546 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.284860 | 0.545 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.284860 | 0.545 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.285196 | 0.545 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.286218 | 0.543 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.286800 | 0.542 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.286800 | 0.542 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.286800 | 0.542 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.286800 | 0.542 |
| R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | 0.286800 | 0.542 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.286800 | 0.542 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.286800 | 0.542 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.286800 | 0.542 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.286800 | 0.542 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.286800 | 0.542 |
| R-HSA-4641265 | Repression of WNT target genes | 0.286800 | 0.542 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.286800 | 0.542 |
| R-HSA-8983711 | OAS antiviral response | 0.286800 | 0.542 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.290564 | 0.537 |
| R-HSA-977225 | Amyloid fiber formation | 0.290564 | 0.537 |
| R-HSA-70326 | Glucose metabolism | 0.300282 | 0.522 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.301716 | 0.520 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.301716 | 0.520 |
| R-HSA-170968 | Frs2-mediated activation | 0.301716 | 0.520 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.301716 | 0.520 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.301716 | 0.520 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.301716 | 0.520 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.301716 | 0.520 |
| R-HSA-5693538 | Homology Directed Repair | 0.304988 | 0.516 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.308010 | 0.511 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.308010 | 0.511 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.308010 | 0.511 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.308010 | 0.511 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.309702 | 0.509 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.309702 | 0.509 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.311484 | 0.507 |
| R-HSA-162587 | HIV Life Cycle | 0.311484 | 0.507 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.313445 | 0.504 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.315582 | 0.501 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.315731 | 0.501 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.315731 | 0.501 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.315731 | 0.501 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.315731 | 0.501 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.315731 | 0.501 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.315731 | 0.501 |
| R-HSA-75153 | Apoptotic execution phase | 0.315731 | 0.501 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.316320 | 0.500 |
| R-HSA-964739 | N-glycan trimming and elongation in the cis-Golgi | 0.316320 | 0.500 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.316320 | 0.500 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.316320 | 0.500 |
| R-HSA-5578768 | Physiological factors | 0.316320 | 0.500 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.317933 | 0.498 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.319176 | 0.496 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.323433 | 0.490 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.323433 | 0.490 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.323799 | 0.490 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.323886 | 0.490 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.323886 | 0.490 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.330621 | 0.481 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.330621 | 0.481 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.330621 | 0.481 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.330621 | 0.481 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.330621 | 0.481 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.330621 | 0.481 |
| R-HSA-171007 | p38MAPK events | 0.330621 | 0.481 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.330621 | 0.481 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.330621 | 0.481 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.330621 | 0.481 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.330621 | 0.481 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.330621 | 0.481 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.331113 | 0.480 |
| R-HSA-9634597 | GPER1 signaling | 0.331113 | 0.480 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.331113 | 0.480 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.342860 | 0.465 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.342860 | 0.465 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.342860 | 0.465 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.344623 | 0.463 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.344623 | 0.463 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.344623 | 0.463 |
| R-HSA-169893 | Prolonged ERK activation events | 0.344623 | 0.463 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.344623 | 0.463 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.344623 | 0.463 |
| R-HSA-202424 | Downstream TCR signaling | 0.347822 | 0.459 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.353996 | 0.451 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.358332 | 0.446 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.358332 | 0.446 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.358332 | 0.446 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.358332 | 0.446 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.358332 | 0.446 |
| R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... | 0.358332 | 0.446 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.358332 | 0.446 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.361564 | 0.442 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.361564 | 0.442 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.364960 | 0.438 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.369099 | 0.433 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.369099 | 0.433 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.371756 | 0.430 |
| R-HSA-3229121 | Glycogen storage diseases | 0.371756 | 0.430 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.371756 | 0.430 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.371756 | 0.430 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.372033 | 0.429 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.376599 | 0.424 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.376599 | 0.424 |
| R-HSA-418597 | G alpha (z) signalling events | 0.384061 | 0.416 |
| R-HSA-9824446 | Viral Infection Pathways | 0.384506 | 0.415 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.384900 | 0.415 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.384900 | 0.415 |
| R-HSA-5358508 | Mismatch Repair | 0.384900 | 0.415 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.384900 | 0.415 |
| R-HSA-210993 | Tie2 Signaling | 0.384900 | 0.415 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.389688 | 0.409 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.391485 | 0.407 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.391485 | 0.407 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.391485 | 0.407 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.397770 | 0.400 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.397770 | 0.400 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.397770 | 0.400 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.397770 | 0.400 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.397770 | 0.400 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.397770 | 0.400 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.397770 | 0.400 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.397770 | 0.400 |
| R-HSA-9834899 | Specification of the neural plate border | 0.397770 | 0.400 |
| R-HSA-9671793 | Diseases of hemostasis | 0.397770 | 0.400 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.398986 | 0.399 |
| R-HSA-1280218 | Adaptive Immune System | 0.404463 | 0.393 |
| R-HSA-163685 | Integration of energy metabolism | 0.404496 | 0.393 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.404612 | 0.393 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.404612 | 0.393 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.404612 | 0.393 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.406211 | 0.391 |
| R-HSA-3322077 | Glycogen synthesis | 0.410371 | 0.387 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.410371 | 0.387 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.410371 | 0.387 |
| R-HSA-71288 | Creatine metabolism | 0.410371 | 0.387 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.410371 | 0.387 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.410371 | 0.387 |
| R-HSA-373753 | Nephrin family interactions | 0.410371 | 0.387 |
| R-HSA-180786 | Extension of Telomeres | 0.413509 | 0.384 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.413509 | 0.384 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.413509 | 0.384 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.418606 | 0.378 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.420763 | 0.376 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.422710 | 0.374 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.422710 | 0.374 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.422710 | 0.374 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.422710 | 0.374 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.422710 | 0.374 |
| R-HSA-167044 | Signalling to RAS | 0.422710 | 0.374 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.422710 | 0.374 |
| R-HSA-210991 | Basigin interactions | 0.422710 | 0.374 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.426956 | 0.370 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.427970 | 0.369 |
| R-HSA-6798695 | Neutrophil degranulation | 0.428701 | 0.368 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.434790 | 0.362 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.434790 | 0.362 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.434790 | 0.362 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.434790 | 0.362 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.434790 | 0.362 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.434790 | 0.362 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.434790 | 0.362 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.435131 | 0.361 |
| R-HSA-9707616 | Heme signaling | 0.435131 | 0.361 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.437296 | 0.359 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.438019 | 0.359 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.441943 | 0.355 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.442242 | 0.354 |
| R-HSA-373755 | Semaphorin interactions | 0.442242 | 0.354 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.446619 | 0.350 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.446619 | 0.350 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.446619 | 0.350 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.446619 | 0.350 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.446619 | 0.350 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.446619 | 0.350 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.446619 | 0.350 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.449304 | 0.347 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.455110 | 0.342 |
| R-HSA-112316 | Neuronal System | 0.458142 | 0.339 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.458201 | 0.339 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.458201 | 0.339 |
| R-HSA-3000170 | Syndecan interactions | 0.458201 | 0.339 |
| R-HSA-8939211 | ESR-mediated signaling | 0.459002 | 0.338 |
| R-HSA-429947 | Deadenylation of mRNA | 0.469541 | 0.328 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.469541 | 0.328 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.469541 | 0.328 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.469541 | 0.328 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.470183 | 0.328 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.470183 | 0.328 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.470183 | 0.328 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.474124 | 0.324 |
| R-HSA-202403 | TCR signaling | 0.476061 | 0.322 |
| R-HSA-167172 | Transcription of the HIV genome | 0.477037 | 0.321 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.478089 | 0.320 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.480645 | 0.318 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.480645 | 0.318 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.487705 | 0.312 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.490582 | 0.309 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.491517 | 0.308 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.495384 | 0.305 |
| R-HSA-1989781 | PPARA activates gene expression | 0.496680 | 0.304 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.497261 | 0.303 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.501407 | 0.300 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.502161 | 0.299 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.502161 | 0.299 |
| R-HSA-8949613 | Cristae formation | 0.502161 | 0.299 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.502161 | 0.299 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.502161 | 0.299 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.502161 | 0.299 |
| R-HSA-264876 | Insulin processing | 0.502161 | 0.299 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.503929 | 0.298 |
| R-HSA-9610379 | HCMV Late Events | 0.505588 | 0.296 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.510482 | 0.292 |
| R-HSA-4086398 | Ca2+ pathway | 0.510482 | 0.292 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.512584 | 0.290 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.512584 | 0.290 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.512584 | 0.290 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.512584 | 0.290 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.512584 | 0.290 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.512584 | 0.290 |
| R-HSA-622312 | Inflammasomes | 0.512584 | 0.290 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.512584 | 0.290 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.512584 | 0.290 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.517001 | 0.287 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.518818 | 0.285 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.518830 | 0.285 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.522789 | 0.282 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.522789 | 0.282 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.522789 | 0.282 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.522789 | 0.282 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.522789 | 0.282 |
| R-HSA-72086 | mRNA Capping | 0.522789 | 0.282 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.522789 | 0.282 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.523142 | 0.281 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.523142 | 0.281 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.523463 | 0.281 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.523463 | 0.281 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.523463 | 0.281 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.532781 | 0.273 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.532781 | 0.273 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.532781 | 0.273 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.532781 | 0.273 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.532781 | 0.273 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.532781 | 0.273 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.542496 | 0.266 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.542496 | 0.266 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.542565 | 0.266 |
| R-HSA-182971 | EGFR downregulation | 0.542565 | 0.266 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.542565 | 0.266 |
| R-HSA-186763 | Downstream signal transduction | 0.542565 | 0.266 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.543314 | 0.265 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.546479 | 0.262 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.548723 | 0.261 |
| R-HSA-199991 | Membrane Trafficking | 0.551289 | 0.259 |
| R-HSA-73894 | DNA Repair | 0.551997 | 0.258 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.552144 | 0.258 |
| R-HSA-1538133 | G0 and Early G1 | 0.552144 | 0.258 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.552144 | 0.258 |
| R-HSA-9833482 | PKR-mediated signaling | 0.554890 | 0.256 |
| R-HSA-6806834 | Signaling by MET | 0.554890 | 0.256 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.558116 | 0.253 |
| R-HSA-9679506 | SARS-CoV Infections | 0.559159 | 0.252 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.560882 | 0.251 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.560997 | 0.251 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.561523 | 0.251 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.561523 | 0.251 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.561523 | 0.251 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.561523 | 0.251 |
| R-HSA-9733709 | Cardiogenesis | 0.561523 | 0.251 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.561523 | 0.251 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.561523 | 0.251 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.570706 | 0.244 |
| R-HSA-189483 | Heme degradation | 0.570706 | 0.244 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.570706 | 0.244 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.572627 | 0.242 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.578208 | 0.238 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.578208 | 0.238 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.578957 | 0.237 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.579698 | 0.237 |
| R-HSA-5205647 | Mitophagy | 0.579698 | 0.237 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.579698 | 0.237 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.579698 | 0.237 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.579698 | 0.237 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.579698 | 0.237 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.579698 | 0.237 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.579698 | 0.237 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.586348 | 0.232 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.588501 | 0.230 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.588501 | 0.230 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.588501 | 0.230 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.596375 | 0.224 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.596375 | 0.224 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.596375 | 0.224 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.597121 | 0.224 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.597121 | 0.224 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.597121 | 0.224 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.597121 | 0.224 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.597121 | 0.224 |
| R-HSA-611105 | Respiratory electron transport | 0.598387 | 0.223 |
| R-HSA-5576891 | Cardiac conduction | 0.600747 | 0.221 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.602060 | 0.220 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.602060 | 0.220 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.605561 | 0.218 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.605561 | 0.218 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.605561 | 0.218 |
| R-HSA-9663891 | Selective autophagy | 0.607684 | 0.216 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.613825 | 0.212 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.613825 | 0.212 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.621915 | 0.206 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.621915 | 0.206 |
| R-HSA-9648002 | RAS processing | 0.621915 | 0.206 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.621915 | 0.206 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.629578 | 0.201 |
| R-HSA-167169 | HIV Transcription Elongation | 0.629837 | 0.201 |
| R-HSA-8982491 | Glycogen metabolism | 0.629837 | 0.201 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.629837 | 0.201 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.629837 | 0.201 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.631985 | 0.199 |
| R-HSA-391251 | Protein folding | 0.634901 | 0.197 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.637594 | 0.195 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.637594 | 0.195 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.637594 | 0.195 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.637594 | 0.195 |
| R-HSA-1632852 | Macroautophagy | 0.649061 | 0.188 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.652624 | 0.185 |
| R-HSA-392499 | Metabolism of proteins | 0.659339 | 0.181 |
| R-HSA-8854214 | TBC/RABGAPs | 0.659904 | 0.181 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.659904 | 0.181 |
| R-HSA-1296071 | Potassium Channels | 0.660620 | 0.180 |
| R-HSA-9609690 | HCMV Early Events | 0.666052 | 0.176 |
| R-HSA-190828 | Gap junction trafficking | 0.667032 | 0.176 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.667032 | 0.176 |
| R-HSA-156581 | Methylation | 0.667032 | 0.176 |
| R-HSA-69236 | G1 Phase | 0.667032 | 0.176 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.667032 | 0.176 |
| R-HSA-774815 | Nucleosome assembly | 0.674011 | 0.171 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.674011 | 0.171 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.674011 | 0.171 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.680844 | 0.167 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.680844 | 0.167 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.680844 | 0.167 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.680844 | 0.167 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.680844 | 0.167 |
| R-HSA-9675135 | Diseases of DNA repair | 0.680844 | 0.167 |
| R-HSA-1483255 | PI Metabolism | 0.689545 | 0.161 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.689545 | 0.161 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.696871 | 0.157 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.698727 | 0.156 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.699535 | 0.155 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.700499 | 0.155 |
| R-HSA-9609507 | Protein localization | 0.700624 | 0.155 |
| R-HSA-9748787 | Azathioprine ADME | 0.706779 | 0.151 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.706779 | 0.151 |
| R-HSA-9612973 | Autophagy | 0.711671 | 0.148 |
| R-HSA-418346 | Platelet homeostasis | 0.712076 | 0.147 |
| R-HSA-9864848 | Complex IV assembly | 0.712927 | 0.147 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.712927 | 0.147 |
| R-HSA-2514856 | The phototransduction cascade | 0.712927 | 0.147 |
| R-HSA-168249 | Innate Immune System | 0.715588 | 0.145 |
| R-HSA-382551 | Transport of small molecules | 0.717307 | 0.144 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.718947 | 0.143 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.718947 | 0.143 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.720699 | 0.142 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.722443 | 0.141 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.724841 | 0.140 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.724841 | 0.140 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.732010 | 0.135 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.737293 | 0.132 |
| R-HSA-5578775 | Ion homeostasis | 0.741793 | 0.130 |
| R-HSA-177929 | Signaling by EGFR | 0.741793 | 0.130 |
| R-HSA-5621480 | Dectin-2 family | 0.747209 | 0.127 |
| R-HSA-1483166 | Synthesis of PA | 0.747209 | 0.127 |
| R-HSA-1643685 | Disease | 0.747790 | 0.126 |
| R-HSA-5619102 | SLC transporter disorders | 0.749502 | 0.125 |
| R-HSA-913531 | Interferon Signaling | 0.750409 | 0.125 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.752512 | 0.123 |
| R-HSA-373760 | L1CAM interactions | 0.760606 | 0.119 |
| R-HSA-9658195 | Leishmania infection | 0.762321 | 0.118 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.762321 | 0.118 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.762787 | 0.118 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.764313 | 0.117 |
| R-HSA-1442490 | Collagen degradation | 0.767764 | 0.115 |
| R-HSA-450294 | MAP kinase activation | 0.767764 | 0.115 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.767970 | 0.115 |
| R-HSA-1268020 | Mitochondrial protein import | 0.772637 | 0.112 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.772637 | 0.112 |
| R-HSA-186797 | Signaling by PDGF | 0.772637 | 0.112 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.777408 | 0.109 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.777408 | 0.109 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.777408 | 0.109 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.782079 | 0.107 |
| R-HSA-15869 | Metabolism of nucleotides | 0.789601 | 0.103 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.791130 | 0.102 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.793531 | 0.100 |
| R-HSA-196807 | Nicotinate metabolism | 0.795514 | 0.099 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.799806 | 0.097 |
| R-HSA-5218859 | Regulated Necrosis | 0.799806 | 0.097 |
| R-HSA-448424 | Interleukin-17 signaling | 0.808123 | 0.093 |
| R-HSA-8978934 | Metabolism of cofactors | 0.812151 | 0.090 |
| R-HSA-189445 | Metabolism of porphyrins | 0.812151 | 0.090 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.812151 | 0.090 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.819956 | 0.086 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.819956 | 0.086 |
| R-HSA-9609646 | HCMV Infection | 0.822386 | 0.085 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.823737 | 0.084 |
| R-HSA-380287 | Centrosome maturation | 0.827438 | 0.082 |
| R-HSA-8852135 | Protein ubiquitination | 0.827438 | 0.082 |
| R-HSA-917937 | Iron uptake and transport | 0.827438 | 0.082 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.834610 | 0.079 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.837229 | 0.077 |
| R-HSA-5663205 | Infectious disease | 0.839905 | 0.076 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.841485 | 0.075 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.844571 | 0.073 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.844571 | 0.073 |
| R-HSA-9664407 | Parasite infection | 0.844571 | 0.073 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.844815 | 0.073 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.845555 | 0.073 |
| R-HSA-6805567 | Keratinization | 0.856645 | 0.067 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.863378 | 0.064 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.866249 | 0.062 |
| R-HSA-397014 | Muscle contraction | 0.868407 | 0.061 |
| R-HSA-70268 | Pyruvate metabolism | 0.869060 | 0.061 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.871812 | 0.060 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.876729 | 0.057 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.877144 | 0.057 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.877144 | 0.057 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.879408 | 0.056 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.879727 | 0.056 |
| R-HSA-2029481 | FCGR activation | 0.887154 | 0.052 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.887154 | 0.052 |
| R-HSA-168256 | Immune System | 0.889101 | 0.051 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.889527 | 0.051 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.896351 | 0.048 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.896351 | 0.048 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.896351 | 0.048 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.896351 | 0.048 |
| R-HSA-1483257 | Phospholipid metabolism | 0.900395 | 0.046 |
| R-HSA-190236 | Signaling by FGFR | 0.900665 | 0.045 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.908736 | 0.042 |
| R-HSA-72306 | tRNA processing | 0.909024 | 0.041 |
| R-HSA-418555 | G alpha (s) signalling events | 0.910565 | 0.041 |
| R-HSA-9833110 | RSV-host interactions | 0.914402 | 0.039 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.915043 | 0.039 |
| R-HSA-6803157 | Antimicrobial peptides | 0.926245 | 0.033 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.927797 | 0.033 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.933689 | 0.030 |
| R-HSA-983712 | Ion channel transport | 0.934445 | 0.029 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.935086 | 0.029 |
| R-HSA-5617833 | Cilium Assembly | 0.935577 | 0.029 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.947797 | 0.023 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.948709 | 0.023 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.956688 | 0.019 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.956688 | 0.019 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.965003 | 0.015 |
| R-HSA-597592 | Post-translational protein modification | 0.966213 | 0.015 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.969857 | 0.013 |
| R-HSA-2187338 | Visual phototransduction | 0.969857 | 0.013 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.973545 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 0.979286 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 0.980482 | 0.009 |
| R-HSA-388396 | GPCR downstream signalling | 0.987478 | 0.005 |
| R-HSA-9748784 | Drug ADME | 0.993671 | 0.003 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.995107 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.995723 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.997460 | 0.001 |
| R-HSA-416476 | G alpha (q) signalling events | 0.997642 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.998685 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.999193 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999268 | 0.000 |
| R-HSA-8957322 | Metabolism of steroids | 0.999352 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999891 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999973 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.896 | 0.408 | 1 | 0.893 |
MOS |
0.890 | 0.243 | 1 | 0.861 |
COT |
0.886 | 0.156 | 2 | 0.851 |
NLK |
0.885 | 0.300 | 1 | 0.893 |
CDC7 |
0.883 | 0.179 | 1 | 0.843 |
JNK2 |
0.883 | 0.400 | 1 | 0.793 |
PIM3 |
0.881 | 0.196 | -3 | 0.879 |
DYRK2 |
0.881 | 0.389 | 1 | 0.838 |
HIPK4 |
0.879 | 0.328 | 1 | 0.844 |
CDKL1 |
0.879 | 0.175 | -3 | 0.851 |
PRPK |
0.878 | -0.051 | -1 | 0.862 |
JNK3 |
0.878 | 0.371 | 1 | 0.815 |
GRK1 |
0.878 | 0.232 | -2 | 0.823 |
CAMK1B |
0.877 | 0.098 | -3 | 0.892 |
ICK |
0.877 | 0.246 | -3 | 0.880 |
SRPK1 |
0.877 | 0.266 | -3 | 0.813 |
SKMLCK |
0.876 | 0.173 | -2 | 0.902 |
ERK5 |
0.876 | 0.174 | 1 | 0.837 |
HIPK1 |
0.876 | 0.383 | 1 | 0.849 |
HIPK2 |
0.876 | 0.411 | 1 | 0.782 |
BMPR1B |
0.875 | 0.213 | 1 | 0.821 |
PIM1 |
0.874 | 0.200 | -3 | 0.837 |
MTOR |
0.874 | 0.098 | 1 | 0.784 |
CLK2 |
0.874 | 0.381 | -3 | 0.806 |
CAMLCK |
0.873 | 0.104 | -2 | 0.878 |
RSK2 |
0.873 | 0.202 | -3 | 0.823 |
P38B |
0.873 | 0.361 | 1 | 0.792 |
BMPR2 |
0.873 | -0.142 | -2 | 0.879 |
DAPK2 |
0.872 | 0.106 | -3 | 0.893 |
ATR |
0.872 | 0.000 | 1 | 0.771 |
CDK1 |
0.872 | 0.336 | 1 | 0.814 |
CDKL5 |
0.872 | 0.176 | -3 | 0.844 |
P38A |
0.872 | 0.339 | 1 | 0.834 |
CDK8 |
0.871 | 0.322 | 1 | 0.822 |
NIK |
0.871 | 0.003 | -3 | 0.899 |
RAF1 |
0.871 | -0.087 | 1 | 0.788 |
CAMK2G |
0.871 | -0.005 | 2 | 0.805 |
P38G |
0.871 | 0.359 | 1 | 0.745 |
CDK18 |
0.870 | 0.361 | 1 | 0.788 |
KIS |
0.870 | 0.359 | 1 | 0.834 |
GRK5 |
0.870 | 0.011 | -3 | 0.876 |
GRK6 |
0.869 | 0.109 | 1 | 0.820 |
GRK7 |
0.869 | 0.188 | 1 | 0.768 |
CLK4 |
0.869 | 0.283 | -3 | 0.818 |
DYRK4 |
0.868 | 0.386 | 1 | 0.799 |
PRKD1 |
0.868 | 0.175 | -3 | 0.866 |
NDR2 |
0.868 | 0.140 | -3 | 0.880 |
IKKB |
0.867 | -0.010 | -2 | 0.766 |
LATS1 |
0.867 | 0.144 | -3 | 0.878 |
PDHK4 |
0.867 | -0.213 | 1 | 0.807 |
CDK19 |
0.866 | 0.330 | 1 | 0.798 |
ERK1 |
0.866 | 0.330 | 1 | 0.784 |
CDK7 |
0.866 | 0.306 | 1 | 0.834 |
CDK5 |
0.866 | 0.309 | 1 | 0.846 |
P38D |
0.866 | 0.373 | 1 | 0.749 |
PKN3 |
0.866 | 0.042 | -3 | 0.861 |
TGFBR1 |
0.865 | 0.091 | -2 | 0.788 |
P90RSK |
0.865 | 0.145 | -3 | 0.824 |
WNK1 |
0.865 | 0.025 | -2 | 0.917 |
DSTYK |
0.864 | -0.054 | 2 | 0.873 |
ALK4 |
0.864 | 0.033 | -2 | 0.819 |
CDK13 |
0.863 | 0.299 | 1 | 0.813 |
CLK1 |
0.863 | 0.284 | -3 | 0.794 |
PRP4 |
0.863 | 0.242 | -3 | 0.809 |
CDK17 |
0.863 | 0.328 | 1 | 0.752 |
MST4 |
0.863 | 0.040 | 2 | 0.851 |
DYRK1B |
0.863 | 0.342 | 1 | 0.822 |
DYRK1A |
0.863 | 0.307 | 1 | 0.849 |
CAMK2D |
0.862 | 0.058 | -3 | 0.865 |
MAPKAPK2 |
0.862 | 0.167 | -3 | 0.778 |
SRPK3 |
0.862 | 0.172 | -3 | 0.784 |
CAMK2B |
0.862 | 0.136 | 2 | 0.788 |
P70S6KB |
0.862 | 0.097 | -3 | 0.835 |
CHAK2 |
0.862 | -0.026 | -1 | 0.826 |
HIPK3 |
0.861 | 0.320 | 1 | 0.827 |
ALK2 |
0.861 | 0.087 | -2 | 0.800 |
CDK14 |
0.861 | 0.334 | 1 | 0.821 |
NUAK2 |
0.861 | 0.050 | -3 | 0.877 |
TBK1 |
0.861 | -0.127 | 1 | 0.675 |
PKR |
0.861 | -0.017 | 1 | 0.778 |
PRKD2 |
0.860 | 0.155 | -3 | 0.820 |
NDR1 |
0.860 | 0.057 | -3 | 0.869 |
PDHK1 |
0.860 | -0.219 | 1 | 0.783 |
CDK3 |
0.860 | 0.304 | 1 | 0.769 |
DLK |
0.860 | -0.150 | 1 | 0.782 |
PKCD |
0.859 | 0.055 | 2 | 0.761 |
MAK |
0.859 | 0.349 | -2 | 0.786 |
MAPKAPK3 |
0.859 | 0.084 | -3 | 0.813 |
MARK4 |
0.859 | 0.008 | 4 | 0.785 |
RSK4 |
0.859 | 0.182 | -3 | 0.799 |
VRK2 |
0.859 | -0.104 | 1 | 0.834 |
MLK1 |
0.859 | -0.128 | 2 | 0.790 |
CAMK2A |
0.858 | 0.132 | 2 | 0.803 |
ACVR2B |
0.858 | 0.073 | -2 | 0.784 |
AURC |
0.858 | 0.167 | -2 | 0.705 |
IKKA |
0.858 | 0.037 | -2 | 0.752 |
CDK12 |
0.858 | 0.302 | 1 | 0.791 |
PKN2 |
0.858 | 0.019 | -3 | 0.871 |
RIPK3 |
0.858 | -0.101 | 3 | 0.712 |
SRPK2 |
0.858 | 0.203 | -3 | 0.737 |
IKKE |
0.858 | -0.127 | 1 | 0.670 |
MEK1 |
0.857 | -0.125 | 2 | 0.813 |
MASTL |
0.857 | -0.198 | -2 | 0.835 |
AMPKA1 |
0.857 | 0.012 | -3 | 0.886 |
DYRK3 |
0.857 | 0.309 | 1 | 0.839 |
RSK3 |
0.857 | 0.113 | -3 | 0.812 |
PASK |
0.857 | 0.143 | -3 | 0.895 |
CDK16 |
0.857 | 0.330 | 1 | 0.765 |
JNK1 |
0.856 | 0.310 | 1 | 0.793 |
ERK2 |
0.856 | 0.261 | 1 | 0.809 |
TSSK2 |
0.856 | 0.009 | -5 | 0.870 |
ACVR2A |
0.856 | 0.043 | -2 | 0.772 |
CDK10 |
0.856 | 0.331 | 1 | 0.812 |
GAK |
0.856 | 0.167 | 1 | 0.843 |
MLK2 |
0.855 | -0.124 | 2 | 0.796 |
BMPR1A |
0.855 | 0.137 | 1 | 0.805 |
TGFBR2 |
0.855 | -0.081 | -2 | 0.785 |
PKACG |
0.855 | 0.089 | -2 | 0.778 |
NEK6 |
0.855 | -0.072 | -2 | 0.859 |
CDK9 |
0.854 | 0.271 | 1 | 0.816 |
ANKRD3 |
0.854 | -0.204 | 1 | 0.790 |
GSK3A |
0.854 | 0.196 | 4 | 0.508 |
PKACB |
0.854 | 0.179 | -2 | 0.715 |
PAK1 |
0.854 | 0.066 | -2 | 0.823 |
TSSK1 |
0.854 | 0.041 | -3 | 0.904 |
ULK2 |
0.854 | -0.238 | 2 | 0.751 |
LATS2 |
0.853 | 0.036 | -5 | 0.766 |
MSK1 |
0.853 | 0.143 | -3 | 0.795 |
HUNK |
0.853 | -0.148 | 2 | 0.779 |
PIM2 |
0.853 | 0.137 | -3 | 0.794 |
MPSK1 |
0.852 | 0.141 | 1 | 0.769 |
GCN2 |
0.852 | -0.213 | 2 | 0.781 |
YSK4 |
0.852 | -0.124 | 1 | 0.713 |
AKT2 |
0.851 | 0.141 | -3 | 0.748 |
NEK7 |
0.851 | -0.206 | -3 | 0.843 |
CDK2 |
0.851 | 0.177 | 1 | 0.861 |
MST3 |
0.851 | 0.036 | 2 | 0.826 |
SGK3 |
0.850 | 0.112 | -3 | 0.808 |
MLK3 |
0.850 | -0.056 | 2 | 0.727 |
MYLK4 |
0.850 | 0.081 | -2 | 0.810 |
NEK9 |
0.850 | -0.206 | 2 | 0.814 |
GRK4 |
0.850 | -0.078 | -2 | 0.833 |
MSK2 |
0.850 | 0.081 | -3 | 0.797 |
ATM |
0.849 | -0.051 | 1 | 0.711 |
AMPKA2 |
0.849 | 0.018 | -3 | 0.858 |
FAM20C |
0.849 | 0.120 | 2 | 0.640 |
RIPK1 |
0.848 | -0.216 | 1 | 0.738 |
AURB |
0.848 | 0.100 | -2 | 0.701 |
PLK1 |
0.848 | -0.100 | -2 | 0.778 |
DNAPK |
0.848 | 0.005 | 1 | 0.635 |
GRK2 |
0.848 | 0.003 | -2 | 0.723 |
PRKX |
0.848 | 0.202 | -3 | 0.738 |
PKCA |
0.847 | 0.038 | 2 | 0.707 |
PRKD3 |
0.847 | 0.070 | -3 | 0.794 |
MOK |
0.847 | 0.291 | 1 | 0.825 |
TAO3 |
0.847 | -0.020 | 1 | 0.746 |
GSK3B |
0.846 | 0.101 | 4 | 0.499 |
TLK2 |
0.846 | -0.088 | 1 | 0.719 |
TTBK2 |
0.846 | -0.178 | 2 | 0.700 |
PKCB |
0.846 | 0.025 | 2 | 0.718 |
QSK |
0.846 | 0.035 | 4 | 0.757 |
PAK3 |
0.846 | -0.009 | -2 | 0.816 |
NIM1 |
0.845 | -0.057 | 3 | 0.754 |
BCKDK |
0.845 | -0.175 | -1 | 0.783 |
MEK5 |
0.845 | -0.249 | 2 | 0.794 |
WNK3 |
0.845 | -0.287 | 1 | 0.738 |
AURA |
0.845 | 0.101 | -2 | 0.676 |
SMMLCK |
0.845 | 0.036 | -3 | 0.854 |
CAMK4 |
0.844 | -0.074 | -3 | 0.850 |
PKCG |
0.844 | 0.004 | 2 | 0.718 |
BRAF |
0.844 | -0.157 | -4 | 0.826 |
SMG1 |
0.844 | -0.065 | 1 | 0.714 |
MEKK2 |
0.844 | -0.141 | 2 | 0.772 |
DAPK3 |
0.843 | 0.103 | -3 | 0.844 |
PAK2 |
0.843 | -0.013 | -2 | 0.808 |
DCAMKL1 |
0.843 | 0.030 | -3 | 0.829 |
NEK2 |
0.843 | -0.136 | 2 | 0.795 |
CHK1 |
0.843 | -0.027 | -3 | 0.836 |
MEKK3 |
0.843 | -0.166 | 1 | 0.748 |
PKG2 |
0.843 | 0.085 | -2 | 0.713 |
MNK2 |
0.843 | 0.033 | -2 | 0.824 |
GCK |
0.843 | 0.004 | 1 | 0.754 |
IRE1 |
0.842 | -0.144 | 1 | 0.719 |
DRAK1 |
0.842 | -0.034 | 1 | 0.747 |
MLK4 |
0.842 | -0.120 | 2 | 0.702 |
PKCZ |
0.842 | -0.029 | 2 | 0.757 |
ERK7 |
0.842 | 0.123 | 2 | 0.558 |
CK2A2 |
0.842 | 0.182 | 1 | 0.736 |
NEK5 |
0.841 | -0.148 | 1 | 0.751 |
MNK1 |
0.841 | 0.037 | -2 | 0.824 |
CDK6 |
0.841 | 0.263 | 1 | 0.801 |
MELK |
0.840 | -0.048 | -3 | 0.839 |
CDK4 |
0.840 | 0.272 | 1 | 0.784 |
MEKK1 |
0.840 | -0.212 | 1 | 0.745 |
MARK3 |
0.840 | 0.012 | 4 | 0.716 |
PAK6 |
0.840 | 0.106 | -2 | 0.752 |
QIK |
0.839 | -0.100 | -3 | 0.857 |
WNK4 |
0.839 | -0.100 | -2 | 0.912 |
PERK |
0.839 | -0.194 | -2 | 0.836 |
DAPK1 |
0.839 | 0.111 | -3 | 0.833 |
PLK3 |
0.839 | -0.109 | 2 | 0.757 |
ULK1 |
0.839 | -0.286 | -3 | 0.805 |
LKB1 |
0.838 | -0.059 | -3 | 0.843 |
PDK1 |
0.838 | -0.073 | 1 | 0.732 |
PKCH |
0.838 | -0.041 | 2 | 0.691 |
AKT1 |
0.838 | 0.115 | -3 | 0.762 |
ZAK |
0.838 | -0.206 | 1 | 0.716 |
CK1E |
0.838 | 0.072 | -3 | 0.623 |
MARK2 |
0.838 | -0.026 | 4 | 0.677 |
CAMKK2 |
0.838 | -0.112 | -2 | 0.785 |
CK1D |
0.837 | 0.086 | -3 | 0.573 |
HPK1 |
0.837 | -0.005 | 1 | 0.737 |
TNIK |
0.837 | -0.021 | 3 | 0.815 |
SIK |
0.837 | 0.012 | -3 | 0.800 |
TAO2 |
0.836 | -0.126 | 2 | 0.822 |
PINK1 |
0.836 | -0.128 | 1 | 0.833 |
CHAK1 |
0.836 | -0.212 | 2 | 0.756 |
TAK1 |
0.836 | -0.101 | 1 | 0.750 |
NEK11 |
0.836 | -0.185 | 1 | 0.736 |
CAMKK1 |
0.836 | -0.188 | -2 | 0.779 |
PKACA |
0.835 | 0.132 | -2 | 0.668 |
MST2 |
0.835 | -0.117 | 1 | 0.755 |
CAMK1G |
0.834 | -0.002 | -3 | 0.804 |
SGK1 |
0.834 | 0.142 | -3 | 0.673 |
MINK |
0.834 | -0.086 | 1 | 0.721 |
GRK3 |
0.834 | 0.018 | -2 | 0.684 |
ROCK2 |
0.834 | 0.105 | -3 | 0.828 |
CK2A1 |
0.833 | 0.168 | 1 | 0.715 |
LRRK2 |
0.833 | -0.133 | 2 | 0.822 |
IRE2 |
0.833 | -0.171 | 2 | 0.703 |
BRSK1 |
0.833 | -0.016 | -3 | 0.829 |
EEF2K |
0.833 | -0.088 | 3 | 0.779 |
HGK |
0.833 | -0.088 | 3 | 0.812 |
KHS1 |
0.832 | -0.003 | 1 | 0.716 |
KHS2 |
0.832 | 0.025 | 1 | 0.735 |
PHKG1 |
0.832 | -0.082 | -3 | 0.861 |
PBK |
0.832 | 0.082 | 1 | 0.769 |
CK1A2 |
0.832 | 0.066 | -3 | 0.576 |
MARK1 |
0.832 | -0.057 | 4 | 0.732 |
NUAK1 |
0.832 | -0.061 | -3 | 0.823 |
HRI |
0.831 | -0.298 | -2 | 0.843 |
TLK1 |
0.831 | -0.205 | -2 | 0.818 |
DCAMKL2 |
0.831 | -0.056 | -3 | 0.842 |
NEK8 |
0.831 | -0.229 | 2 | 0.786 |
DMPK1 |
0.830 | 0.133 | -3 | 0.808 |
CAMK1D |
0.830 | 0.048 | -3 | 0.732 |
MAP3K15 |
0.830 | -0.146 | 1 | 0.699 |
BUB1 |
0.830 | 0.100 | -5 | 0.830 |
P70S6K |
0.829 | 0.038 | -3 | 0.752 |
VRK1 |
0.829 | -0.170 | 2 | 0.790 |
MEKK6 |
0.829 | -0.154 | 1 | 0.723 |
SSTK |
0.829 | -0.040 | 4 | 0.743 |
IRAK4 |
0.828 | -0.201 | 1 | 0.714 |
NEK4 |
0.828 | -0.192 | 1 | 0.713 |
MAPKAPK5 |
0.828 | -0.062 | -3 | 0.758 |
MRCKB |
0.828 | 0.086 | -3 | 0.783 |
SBK |
0.827 | 0.143 | -3 | 0.633 |
PKCE |
0.827 | 0.039 | 2 | 0.702 |
NEK1 |
0.827 | -0.158 | 1 | 0.721 |
MRCKA |
0.827 | 0.070 | -3 | 0.792 |
PLK4 |
0.826 | -0.187 | 2 | 0.584 |
BRSK2 |
0.826 | -0.105 | -3 | 0.843 |
AKT3 |
0.826 | 0.128 | -3 | 0.693 |
PKCT |
0.826 | -0.038 | 2 | 0.699 |
LOK |
0.826 | -0.097 | -2 | 0.794 |
PKCI |
0.825 | -0.029 | 2 | 0.725 |
MST1 |
0.824 | -0.179 | 1 | 0.727 |
PDHK3_TYR |
0.824 | 0.353 | 4 | 0.872 |
BIKE |
0.822 | 0.086 | 1 | 0.755 |
CHK2 |
0.822 | 0.041 | -3 | 0.693 |
SLK |
0.821 | -0.110 | -2 | 0.744 |
YSK1 |
0.821 | -0.120 | 2 | 0.792 |
PLK2 |
0.821 | -0.045 | -3 | 0.770 |
SNRK |
0.820 | -0.245 | 2 | 0.630 |
PAK5 |
0.819 | 0.038 | -2 | 0.695 |
OSR1 |
0.818 | -0.101 | 2 | 0.778 |
CRIK |
0.818 | 0.103 | -3 | 0.761 |
MEK2 |
0.817 | -0.306 | 2 | 0.778 |
TTBK1 |
0.817 | -0.219 | 2 | 0.616 |
ROCK1 |
0.816 | 0.065 | -3 | 0.795 |
CAMK1A |
0.816 | 0.041 | -3 | 0.711 |
HASPIN |
0.815 | -0.016 | -1 | 0.686 |
PAK4 |
0.815 | 0.055 | -2 | 0.700 |
TTK |
0.815 | -0.117 | -2 | 0.806 |
ALPHAK3 |
0.815 | -0.069 | -1 | 0.775 |
CK1G1 |
0.814 | -0.004 | -3 | 0.606 |
PDHK4_TYR |
0.814 | 0.178 | 2 | 0.857 |
MYO3B |
0.814 | -0.074 | 2 | 0.808 |
IRAK1 |
0.814 | -0.376 | -1 | 0.741 |
PKN1 |
0.813 | -0.007 | -3 | 0.769 |
MAP2K4_TYR |
0.813 | 0.140 | -1 | 0.884 |
PHKG2 |
0.813 | -0.104 | -3 | 0.831 |
MAP2K6_TYR |
0.812 | 0.147 | -1 | 0.883 |
ASK1 |
0.811 | -0.205 | 1 | 0.691 |
AAK1 |
0.811 | 0.141 | 1 | 0.673 |
BMPR2_TYR |
0.810 | 0.115 | -1 | 0.889 |
TESK1_TYR |
0.809 | 0.001 | 3 | 0.860 |
PKMYT1_TYR |
0.809 | 0.068 | 3 | 0.832 |
STK33 |
0.808 | -0.207 | 2 | 0.600 |
MYO3A |
0.808 | -0.143 | 1 | 0.717 |
PDHK1_TYR |
0.808 | 0.066 | -1 | 0.894 |
YANK3 |
0.806 | -0.046 | 2 | 0.415 |
MAP2K7_TYR |
0.805 | -0.109 | 2 | 0.830 |
NEK3 |
0.805 | -0.227 | 1 | 0.680 |
LIMK2_TYR |
0.804 | 0.050 | -3 | 0.900 |
TAO1 |
0.803 | -0.164 | 1 | 0.658 |
RIPK2 |
0.802 | -0.361 | 1 | 0.671 |
PINK1_TYR |
0.799 | -0.188 | 1 | 0.796 |
TXK |
0.798 | 0.112 | 1 | 0.822 |
EPHA6 |
0.798 | 0.011 | -1 | 0.869 |
EPHB4 |
0.797 | -0.015 | -1 | 0.842 |
STLK3 |
0.795 | -0.277 | 1 | 0.683 |
PKG1 |
0.794 | 0.011 | -2 | 0.633 |
RET |
0.793 | -0.177 | 1 | 0.737 |
LIMK1_TYR |
0.792 | -0.199 | 2 | 0.821 |
YES1 |
0.791 | -0.039 | -1 | 0.859 |
FGR |
0.791 | -0.065 | 1 | 0.805 |
EPHA4 |
0.790 | -0.012 | 2 | 0.760 |
ABL2 |
0.790 | -0.045 | -1 | 0.799 |
CK1A |
0.790 | 0.049 | -3 | 0.486 |
LCK |
0.789 | 0.029 | -1 | 0.853 |
MST1R |
0.789 | -0.205 | 3 | 0.773 |
BLK |
0.788 | 0.052 | -1 | 0.860 |
SRMS |
0.787 | -0.055 | 1 | 0.819 |
TYK2 |
0.787 | -0.283 | 1 | 0.730 |
HCK |
0.787 | -0.064 | -1 | 0.850 |
JAK2 |
0.787 | -0.220 | 1 | 0.728 |
ROS1 |
0.786 | -0.209 | 3 | 0.722 |
ABL1 |
0.786 | -0.068 | -1 | 0.793 |
FER |
0.786 | -0.151 | 1 | 0.832 |
FYN |
0.786 | 0.061 | -1 | 0.845 |
TYRO3 |
0.786 | -0.232 | 3 | 0.754 |
ITK |
0.785 | -0.056 | -1 | 0.809 |
CSF1R |
0.785 | -0.179 | 3 | 0.753 |
DDR1 |
0.785 | -0.222 | 4 | 0.774 |
TNK2 |
0.784 | -0.094 | 3 | 0.720 |
EPHB1 |
0.784 | -0.095 | 1 | 0.803 |
EPHB3 |
0.783 | -0.080 | -1 | 0.825 |
EPHB2 |
0.783 | -0.056 | -1 | 0.824 |
INSRR |
0.783 | -0.147 | 3 | 0.704 |
JAK3 |
0.783 | -0.185 | 1 | 0.718 |
BMX |
0.779 | -0.062 | -1 | 0.733 |
MERTK |
0.779 | -0.109 | 3 | 0.745 |
FGFR2 |
0.778 | -0.204 | 3 | 0.760 |
KIT |
0.778 | -0.193 | 3 | 0.757 |
KDR |
0.778 | -0.164 | 3 | 0.717 |
NEK10_TYR |
0.777 | -0.164 | 1 | 0.612 |
TNNI3K_TYR |
0.777 | -0.105 | 1 | 0.740 |
EPHA7 |
0.776 | -0.076 | 2 | 0.755 |
MET |
0.776 | -0.139 | 3 | 0.748 |
JAK1 |
0.776 | -0.142 | 1 | 0.673 |
TEC |
0.775 | -0.116 | -1 | 0.747 |
PTK2 |
0.775 | 0.069 | -1 | 0.826 |
TEK |
0.774 | -0.211 | 3 | 0.689 |
TNK1 |
0.774 | -0.175 | 3 | 0.746 |
CK1G3 |
0.774 | -0.004 | -3 | 0.439 |
YANK2 |
0.774 | -0.091 | 2 | 0.428 |
FLT1 |
0.773 | -0.134 | -1 | 0.833 |
AXL |
0.773 | -0.206 | 3 | 0.739 |
EPHA3 |
0.773 | -0.141 | 2 | 0.727 |
PDGFRB |
0.773 | -0.308 | 3 | 0.760 |
SYK |
0.772 | 0.061 | -1 | 0.798 |
FGFR1 |
0.772 | -0.250 | 3 | 0.727 |
FLT3 |
0.771 | -0.284 | 3 | 0.751 |
LYN |
0.771 | -0.103 | 3 | 0.683 |
WEE1_TYR |
0.771 | -0.159 | -1 | 0.736 |
SRC |
0.771 | -0.054 | -1 | 0.833 |
PTK2B |
0.771 | -0.058 | -1 | 0.776 |
ERBB2 |
0.769 | -0.211 | 1 | 0.720 |
BTK |
0.769 | -0.262 | -1 | 0.767 |
EPHA5 |
0.769 | -0.080 | 2 | 0.736 |
FRK |
0.769 | -0.147 | -1 | 0.851 |
PTK6 |
0.768 | -0.257 | -1 | 0.719 |
FGFR3 |
0.768 | -0.202 | 3 | 0.730 |
EPHA8 |
0.768 | -0.087 | -1 | 0.816 |
LTK |
0.767 | -0.223 | 3 | 0.701 |
ALK |
0.767 | -0.241 | 3 | 0.668 |
EPHA1 |
0.767 | -0.180 | 3 | 0.721 |
NTRK1 |
0.767 | -0.280 | -1 | 0.804 |
DDR2 |
0.766 | -0.100 | 3 | 0.684 |
EGFR |
0.765 | -0.109 | 1 | 0.640 |
PDGFRA |
0.764 | -0.382 | 3 | 0.754 |
INSR |
0.762 | -0.252 | 3 | 0.682 |
NTRK3 |
0.762 | -0.215 | -1 | 0.754 |
FLT4 |
0.762 | -0.280 | 3 | 0.720 |
MATK |
0.761 | -0.183 | -1 | 0.715 |
CSK |
0.760 | -0.199 | 2 | 0.758 |
NTRK2 |
0.759 | -0.342 | 3 | 0.717 |
FGFR4 |
0.759 | -0.153 | -1 | 0.764 |
ERBB4 |
0.757 | -0.062 | 1 | 0.682 |
EPHA2 |
0.757 | -0.097 | -1 | 0.780 |
CK1G2 |
0.756 | -0.015 | -3 | 0.529 |
IGF1R |
0.749 | -0.218 | 3 | 0.626 |
ZAP70 |
0.747 | -0.023 | -1 | 0.712 |
MUSK |
0.744 | -0.244 | 1 | 0.628 |
FES |
0.738 | -0.193 | -1 | 0.705 |