Motif 1185 (n=50)
Position-wise Probabilities
Download
uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A096LP55 | UQCRHL | T11 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
A2RU30 | TESPA1 | T9 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
B5ME19 | EIF3CL | S9 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
O43294 | TGFB1I1 | S9 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
O43776 | NARS1 | S9 | ochoa | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
P02730 | SLC4A1 | Y8 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
P07919 | UQCRH | T11 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
P17480 | UBTF | T9 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
P18615 | NELFE | S9 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
P28347 | TEAD1 | S9 | ochoa | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
P30153 | PPP2R1A | S9 | ochoa | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:8694763}. |
P31321 | PRKAR1B | S9 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
P40855 | PEX19 | S9 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
P47755 | CAPZA2 | S9 | ochoa | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
P49810 | PSEN2 | S9 | psp | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
P52907 | CAPZA1 | S9 | ochoa|psp | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
P54619 | PRKAG1 | S9 | ochoa | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:21680840, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:21680840, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:21680840, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:21680840, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:21680840, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:21680840, PubMed:24563466). {ECO:0000269|PubMed:21680840, ECO:0000269|PubMed:24563466}. |
P61457 | PCBD1 | S9 | ochoa | Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) | Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001). {ECO:0000250|UniProtKB:P61459, ECO:0000269|PubMed:24204001}. |
P62316 | SNRPD2 | S9 | ochoa | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}. |
P63165 | SUMO1 | S9 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
P78362 | SRPK2 | S9 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
Q15311 | RALBP1 | T9 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
Q16667 | CDKN3 | T9 | ochoa | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}. |
Q4V339 | ZNG1F | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). {ECO:0000250|UniProtKB:Q8VEH6, ECO:0000269|PubMed:35584702}. |
Q5JTY5 | ZNG1C | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q5RIA9 | ZNG1E | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q5SYC1 | CLVS2 | S9 | ochoa | Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2) | Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}. |
Q6ZW76 | ANKS3 | S9 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
Q86SQ7 | SDCCAG8 | T9 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
Q8IYB3 | SRRM1 | T9 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q8IYE0 | CCDC146 | T8 | ochoa | Coiled-coil domain-containing protein 146 | Essential for sperm flagellum biogenesis and male fertility. {ECO:0000250|UniProtKB:E9Q9F7}. |
Q8N3U4 | STAG2 | T9 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
Q969F1 | GTF3C6 | S9 | ochoa | General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}. |
Q96DU7 | ITPKC | S9 | ochoa | Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}. |
Q99613 | EIF3C | S9 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
Q9BRT8 | ZNG1A | S7 | ochoa | Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6) | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}. |
Q9H0S4 | DDX47 | S9 | ochoa | Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) | Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068). {ECO:0000250|UniProtKB:Q9VIF6, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}. |
Q9H813 | PACC1 | S9 | ochoa | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) | Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}. |
Q9NVA2 | SEPTIN11 | S9 | ochoa | Septin-11 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}. |
Q9NWV8 | BABAM1 | S8 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
Q9NWV8 | BABAM1 | T10 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
Q9NXR1 | NDE1 | S9 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
Q9NZT2 | OGFR | T9 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
Q9P215 | POGK | S11 | ochoa | Pogo transposable element with KRAB domain | None |
Q9ULJ1 | ODF2L | S9 | ochoa | Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) (ODF2-like protein) | Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. {ECO:0000269|PubMed:28775150}. |
Q9Y2J2 | EPB41L3 | S9 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
P62906 | RPL10A | T9 | Sugiyama | Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
P61024 | CKS1B | S9 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
P13693 | TPT1 | S9 | Sugiyama | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
Q9UKG9 | CROT | T9 | Sugiyama | Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:10486279}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.009457 | 2.024 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.028109 | 1.551 |
R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.031184 | 1.506 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.031184 | 1.506 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.040352 | 1.394 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.043389 | 1.363 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.043389 | 1.363 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.043389 | 1.363 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.046417 | 1.333 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.049435 | 1.306 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.049435 | 1.306 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.049435 | 1.306 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.049435 | 1.306 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.049435 | 1.306 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.058434 | 1.233 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.061415 | 1.212 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.001524 | 2.817 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.001524 | 2.817 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.073246 | 1.135 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.001714 | 2.766 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.002213 | 2.655 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.082024 | 1.086 |
R-HSA-380287 | Centrosome maturation | 0.002371 | 2.625 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.003668 | 2.436 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.099335 | 1.003 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.099335 | 1.003 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.099335 | 1.003 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.102189 | 0.991 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.102189 | 0.991 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.102189 | 0.991 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.004693 | 2.329 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.006601 | 2.180 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.007220 | 2.141 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.007220 | 2.141 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.035972 | 1.444 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.035972 | 1.444 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.040228 | 1.395 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.040955 | 1.388 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.043914 | 1.357 |
R-HSA-192823 | Viral mRNA Translation | 0.050850 | 1.294 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.054863 | 1.261 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.003883 | 2.411 |
R-HSA-389513 | Co-inhibition by CTLA4 | 0.076181 | 1.118 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.084931 | 1.071 |
R-HSA-156902 | Peptide chain elongation | 0.038077 | 1.419 |
R-HSA-9948299 | Ribosome-associated quality control | 0.086712 | 1.062 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.099335 | 1.003 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.107870 | 0.967 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.022161 | 1.654 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.044666 | 1.350 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.006601 | 2.180 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.058434 | 1.233 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.107870 | 0.967 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.009093 | 2.041 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.044666 | 1.350 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.008210 | 2.086 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.048496 | 1.314 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.008210 | 2.086 |
R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.025025 | 1.602 |
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.034250 | 1.465 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.040352 | 1.394 |
R-HSA-4839744 | Signaling by APC mutants | 0.043389 | 1.363 |
R-HSA-9865881 | Complex III assembly | 0.004165 | 2.380 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.046417 | 1.333 |
R-HSA-202670 | ERKs are inactivated | 0.046417 | 1.333 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.046417 | 1.333 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.046417 | 1.333 |
R-HSA-163615 | PKA activation | 0.070302 | 1.153 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.070302 | 1.153 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.102189 | 0.991 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.105034 | 0.979 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.113516 | 0.945 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.121920 | 0.914 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.127478 | 0.895 |
R-HSA-68877 | Mitotic Prometaphase | 0.004588 | 2.338 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.116326 | 0.934 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.127478 | 0.895 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.041688 | 1.380 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.102189 | 0.991 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.027991 | 1.553 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.020094 | 1.697 |
R-HSA-9839383 | TGFBR3 PTM regulation | 0.034250 | 1.465 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.046417 | 1.333 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.052444 | 1.280 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.055444 | 1.256 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.003165 | 2.500 |
R-HSA-5689901 | Metalloprotease DUBs | 0.096472 | 1.016 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.102189 | 0.991 |
R-HSA-72766 | Translation | 0.054010 | 1.268 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.079107 | 1.102 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.082024 | 1.086 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.017189 | 1.765 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.099335 | 1.003 |
R-HSA-2408557 | Selenocysteine synthesis | 0.049276 | 1.307 |
R-HSA-72312 | rRNA processing | 0.045787 | 1.339 |
R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.001219 | 2.914 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.037306 | 1.428 |
R-HSA-425381 | Bicarbonate transporters | 0.043389 | 1.363 |
R-HSA-877312 | Regulation of IFNG signaling | 0.049435 | 1.306 |
R-HSA-180024 | DARPP-32 events | 0.005612 | 2.251 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.061415 | 1.212 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.073246 | 1.135 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.051644 | 1.287 |
R-HSA-69236 | G1 Phase | 0.011971 | 1.922 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.011971 | 1.922 |
R-HSA-68886 | M Phase | 0.008872 | 2.052 |
R-HSA-9613354 | Lipophagy | 0.037306 | 1.428 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 0.037306 | 1.428 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.037306 | 1.428 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.056499 | 1.248 |
R-HSA-68882 | Mitotic Anaphase | 0.006667 | 2.176 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.006765 | 2.170 |
R-HSA-8953854 | Metabolism of RNA | 0.052564 | 1.279 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.124703 | 0.904 |
R-HSA-69275 | G2/M Transition | 0.027307 | 1.564 |
R-HSA-9609507 | Protein localization | 0.102286 | 0.990 |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.049435 | 1.306 |
R-HSA-8964208 | Phenylalanine metabolism | 0.079107 | 1.102 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.119127 | 0.924 |
R-HSA-5673000 | RAF activation | 0.121920 | 0.914 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.045422 | 1.343 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.027991 | 1.553 |
R-HSA-5617833 | Cilium Assembly | 0.028685 | 1.542 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.079107 | 1.102 |
R-HSA-9659379 | Sensory processing of sound | 0.002706 | 2.568 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.019286 | 1.715 |
R-HSA-69242 | S Phase | 0.097337 | 1.012 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.002698 | 2.569 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 0.055444 | 1.256 |
R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.073246 | 1.135 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.001848 | 2.733 |
R-HSA-198753 | ERK/MAPK targets | 0.079107 | 1.102 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.096472 | 1.016 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.104284 | 0.982 |
R-HSA-9711097 | Cellular response to starvation | 0.107303 | 0.969 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.010367 | 1.984 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.084931 | 1.071 |
R-HSA-1640170 | Cell Cycle | 0.007839 | 2.106 |
R-HSA-438064 | Post NMDA receptor activation events | 0.037370 | 1.427 |
R-HSA-611105 | Respiratory electron transport | 0.129056 | 0.889 |
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.073246 | 1.135 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.023783 | 1.624 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.127478 | 0.895 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.031905 | 1.496 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.051644 | 1.287 |
R-HSA-9683610 | Maturation of nucleoprotein | 0.052444 | 1.280 |
R-HSA-432142 | Platelet sensitization by LDL | 0.070302 | 1.153 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.080149 | 1.096 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.022616 | 1.646 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.096472 | 1.016 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.101290 | 0.994 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.057104 | 1.243 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.060663 | 1.217 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.058102 | 1.236 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.023706 | 1.625 |
R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.087830 | 1.056 |
R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.093600 | 1.029 |
R-HSA-1980145 | Signaling by NOTCH2 | 0.121920 | 0.914 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.095378 | 1.021 |
R-HSA-111933 | Calmodulin induced events | 0.127478 | 0.895 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.116326 | 0.934 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.116326 | 0.934 |
R-HSA-111997 | CaM pathway | 0.127478 | 0.895 |
R-HSA-163685 | Integration of energy metabolism | 0.084820 | 1.072 |
R-HSA-69206 | G1/S Transition | 0.072855 | 1.138 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.102286 | 0.990 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.119127 | 0.924 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.050061 | 1.301 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.127478 | 0.895 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.105034 | 0.979 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.113410 | 0.945 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.122736 | 0.911 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.096356 | 1.016 |
R-HSA-111885 | Opioid Signalling | 0.051644 | 1.287 |
R-HSA-9833482 | PKR-mediated signaling | 0.031905 | 1.496 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.024373 | 1.613 |
R-HSA-9694635 | Translation of Structural Proteins | 0.029945 | 1.524 |
R-HSA-2132295 | MHC class II antigen presentation | 0.070179 | 1.154 |
R-HSA-168255 | Influenza Infection | 0.130117 | 0.886 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.109328 | 0.961 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.041688 | 1.380 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.103284 | 0.986 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.022622 | 1.645 |
R-HSA-9020591 | Interleukin-12 signaling | 0.029303 | 1.533 |
R-HSA-9675108 | Nervous system development | 0.123343 | 0.909 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.111721 | 0.952 |
R-HSA-447115 | Interleukin-12 family signaling | 0.037370 | 1.427 |
R-HSA-8963691 | Phenylalanine and tyrosine metabolism | 0.130245 | 0.885 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.133003 | 0.876 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.135752 | 0.867 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.135752 | 0.867 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.138493 | 0.859 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.138493 | 0.859 |
R-HSA-167169 | HIV Transcription Elongation | 0.138493 | 0.859 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.138493 | 0.859 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.138493 | 0.859 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.143949 | 0.842 |
R-HSA-9683701 | Translation of Structural Proteins | 0.143949 | 0.842 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.146269 | 0.835 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.146664 | 0.834 |
R-HSA-165159 | MTOR signalling | 0.146664 | 0.834 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.146664 | 0.834 |
R-HSA-111996 | Ca-dependent events | 0.146664 | 0.834 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.146664 | 0.834 |
R-HSA-5654743 | Signaling by FGFR4 | 0.149371 | 0.826 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.152069 | 0.818 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.152069 | 0.818 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.152845 | 0.816 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.152845 | 0.816 |
R-HSA-9824446 | Viral Infection Pathways | 0.153643 | 0.813 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.154759 | 0.810 |
R-HSA-5654741 | Signaling by FGFR3 | 0.154759 | 0.810 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.154759 | 0.810 |
R-HSA-1489509 | DAG and IP3 signaling | 0.154759 | 0.810 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.155050 | 0.810 |
R-HSA-376176 | Signaling by ROBO receptors | 0.156155 | 0.806 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.157441 | 0.803 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.157441 | 0.803 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.157441 | 0.803 |
R-HSA-72172 | mRNA Splicing | 0.158370 | 0.800 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.160114 | 0.796 |
R-HSA-199991 | Membrane Trafficking | 0.161293 | 0.792 |
R-HSA-8953897 | Cellular responses to stimuli | 0.161715 | 0.791 |
R-HSA-9634597 | GPER1 signaling | 0.162779 | 0.788 |
R-HSA-389356 | Co-stimulation by CD28 | 0.162779 | 0.788 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.162779 | 0.788 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.167288 | 0.777 |
R-HSA-72187 | mRNA 3'-end processing | 0.173356 | 0.761 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.173356 | 0.761 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.173356 | 0.761 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.173356 | 0.761 |
R-HSA-6794361 | Neurexins and neuroligins | 0.173356 | 0.761 |
R-HSA-1221632 | Meiotic synapsis | 0.175980 | 0.755 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.175980 | 0.755 |
R-HSA-72649 | Translation initiation complex formation | 0.178596 | 0.748 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.178596 | 0.748 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.181203 | 0.742 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.183803 | 0.736 |
R-HSA-5654736 | Signaling by FGFR1 | 0.183803 | 0.736 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.183803 | 0.736 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.188977 | 0.724 |
R-HSA-191859 | snRNP Assembly | 0.191552 | 0.718 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.191552 | 0.718 |
R-HSA-9033241 | Peroxisomal protein import | 0.191552 | 0.718 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.194119 | 0.712 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.194119 | 0.712 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.194119 | 0.712 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.194119 | 0.712 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.194119 | 0.712 |
R-HSA-379724 | tRNA Aminoacylation | 0.194119 | 0.712 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.196678 | 0.706 |
R-HSA-445717 | Aquaporin-mediated transport | 0.196678 | 0.706 |
R-HSA-112043 | PLC beta mediated events | 0.196678 | 0.706 |
R-HSA-450294 | MAP kinase activation | 0.196678 | 0.706 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.199226 | 0.701 |
R-HSA-112316 | Neuronal System | 0.201665 | 0.695 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.201773 | 0.695 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.209355 | 0.679 |
R-HSA-112040 | G-protein mediated events | 0.211867 | 0.674 |
R-HSA-167172 | Transcription of the HIV genome | 0.214371 | 0.669 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.219355 | 0.659 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.219355 | 0.659 |
R-HSA-448424 | Interleukin-17 signaling | 0.219355 | 0.659 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.221836 | 0.654 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.221836 | 0.654 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.224309 | 0.649 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.224309 | 0.649 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.224309 | 0.649 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.226774 | 0.644 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.226774 | 0.644 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.226774 | 0.644 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.229231 | 0.640 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.229231 | 0.640 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.229231 | 0.640 |
R-HSA-1236394 | Signaling by ERBB4 | 0.229231 | 0.640 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.234123 | 0.631 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.234123 | 0.631 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.238984 | 0.622 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.238984 | 0.622 |
R-HSA-5654738 | Signaling by FGFR2 | 0.243816 | 0.613 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.243816 | 0.613 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.243816 | 0.613 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.244546 | 0.612 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.246220 | 0.609 |
R-HSA-1280218 | Adaptive Immune System | 0.247891 | 0.606 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.248617 | 0.604 |
R-HSA-109582 | Hemostasis | 0.250481 | 0.601 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.253388 | 0.596 |
R-HSA-390918 | Peroxisomal lipid metabolism | 0.253388 | 0.596 |
R-HSA-1500620 | Meiosis | 0.255763 | 0.592 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.255763 | 0.592 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.258130 | 0.588 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.260489 | 0.584 |
R-HSA-9663891 | Selective autophagy | 0.265187 | 0.576 |
R-HSA-422475 | Axon guidance | 0.266360 | 0.575 |
R-HSA-5653656 | Vesicle-mediated transport | 0.267317 | 0.573 |
R-HSA-9679506 | SARS-CoV Infections | 0.274983 | 0.561 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.276802 | 0.558 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.290504 | 0.537 |
R-HSA-74160 | Gene expression (Transcription) | 0.291569 | 0.535 |
R-HSA-190236 | Signaling by FGFR | 0.292763 | 0.533 |
R-HSA-422356 | Regulation of insulin secretion | 0.292763 | 0.533 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.292763 | 0.533 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.292763 | 0.533 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.292763 | 0.533 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.295014 | 0.530 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.296288 | 0.528 |
R-HSA-5663205 | Infectious disease | 0.296382 | 0.528 |
R-HSA-70171 | Glycolysis | 0.297259 | 0.527 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.297259 | 0.527 |
R-HSA-5610787 | Hedgehog 'off' state | 0.297259 | 0.527 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.310580 | 0.508 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.310580 | 0.508 |
R-HSA-418346 | Platelet homeostasis | 0.312776 | 0.505 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.317148 | 0.499 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.317382 | 0.498 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.318550 | 0.497 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.319323 | 0.496 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.321492 | 0.493 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.321492 | 0.493 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.325809 | 0.487 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.327957 | 0.484 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.329856 | 0.482 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.330099 | 0.481 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.334363 | 0.476 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.334363 | 0.476 |
R-HSA-449147 | Signaling by Interleukins | 0.335980 | 0.474 |
R-HSA-73894 | DNA Repair | 0.339507 | 0.469 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.340708 | 0.468 |
R-HSA-70326 | Glucose metabolism | 0.340708 | 0.468 |
R-HSA-5693538 | Homology Directed Repair | 0.342810 | 0.465 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.344905 | 0.462 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.344905 | 0.462 |
R-HSA-68875 | Mitotic Prophase | 0.346994 | 0.460 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.351152 | 0.455 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.351152 | 0.455 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.353221 | 0.452 |
R-HSA-392499 | Metabolism of proteins | 0.361196 | 0.442 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.361433 | 0.442 |
R-HSA-69481 | G2/M Checkpoints | 0.363470 | 0.440 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.365501 | 0.437 |
R-HSA-913531 | Interferon Signaling | 0.367158 | 0.435 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.369544 | 0.432 |
R-HSA-1474165 | Reproduction | 0.371555 | 0.430 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.385462 | 0.414 |
R-HSA-5358351 | Signaling by Hedgehog | 0.389380 | 0.410 |
R-HSA-418594 | G alpha (i) signalling events | 0.394384 | 0.404 |
R-HSA-1632852 | Macroautophagy | 0.395210 | 0.403 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.399067 | 0.399 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.410493 | 0.387 |
R-HSA-166520 | Signaling by NTRKs | 0.410493 | 0.387 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.411147 | 0.386 |
R-HSA-1643685 | Disease | 0.417831 | 0.379 |
R-HSA-2262752 | Cellular responses to stress | 0.419693 | 0.377 |
R-HSA-73887 | Death Receptor Signaling | 0.421706 | 0.375 |
R-HSA-9612973 | Autophagy | 0.425397 | 0.371 |
R-HSA-162587 | HIV Life Cycle | 0.427234 | 0.369 |
R-HSA-877300 | Interferon gamma signaling | 0.430890 | 0.366 |
R-HSA-9006936 | Signaling by TGFB family members | 0.432710 | 0.364 |
R-HSA-5619102 | SLC transporter disorders | 0.445289 | 0.351 |
R-HSA-418555 | G alpha (s) signalling events | 0.454105 | 0.343 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.457594 | 0.340 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.457594 | 0.340 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.459995 | 0.337 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.461060 | 0.336 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.463457 | 0.334 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.474709 | 0.324 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.488019 | 0.312 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.509671 | 0.293 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.524471 | 0.280 |
R-HSA-162906 | HIV Infection | 0.545400 | 0.263 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.546860 | 0.262 |
R-HSA-8939211 | ESR-mediated signaling | 0.559794 | 0.252 |
R-HSA-157118 | Signaling by NOTCH | 0.564024 | 0.249 |
R-HSA-212436 | Generic Transcription Pathway | 0.565253 | 0.248 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.573741 | 0.241 |
R-HSA-5688426 | Deubiquitination | 0.584585 | 0.233 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.601599 | 0.221 |
R-HSA-9658195 | Leishmania infection | 0.617995 | 0.209 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.617995 | 0.209 |
R-HSA-382551 | Transport of small molecules | 0.622483 | 0.206 |
R-HSA-597592 | Post-translational protein modification | 0.625827 | 0.204 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.627735 | 0.202 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.634879 | 0.197 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.636057 | 0.197 |
R-HSA-195721 | Signaling by WNT | 0.638401 | 0.195 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.666481 | 0.176 |
R-HSA-5683057 | MAPK family signaling cascades | 0.691422 | 0.160 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.707023 | 0.151 |
R-HSA-388396 | GPCR downstream signalling | 0.724118 | 0.140 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.738504 | 0.132 |
R-HSA-8978868 | Fatty acid metabolism | 0.746873 | 0.127 |
R-HSA-1266738 | Developmental Biology | 0.762801 | 0.118 |
R-HSA-9709957 | Sensory Perception | 0.771413 | 0.113 |
R-HSA-372790 | Signaling by GPCR | 0.774165 | 0.111 |
R-HSA-162582 | Signal Transduction | 0.774904 | 0.111 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.783524 | 0.106 |
R-HSA-168256 | Immune System | 0.804501 | 0.094 |
R-HSA-168249 | Innate Immune System | 0.812075 | 0.090 |
R-HSA-1430728 | Metabolism | 0.873466 | 0.059 |
R-HSA-556833 | Metabolism of lipids | 0.993383 | 0.003 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CK2A2 |
0.775 | 0.541 | 1 | 0.761 |
CK2A1 |
0.766 | 0.496 | 1 | 0.749 |
MOS |
0.758 | 0.277 | 1 | 0.728 |
BMPR1B |
0.757 | 0.248 | 1 | 0.747 |
GRK7 |
0.752 | 0.321 | 1 | 0.601 |
GRK1 |
0.750 | 0.266 | -2 | 0.814 |
ALK2 |
0.749 | 0.262 | -2 | 0.804 |
FAM20C |
0.748 | 0.372 | 2 | 0.842 |
TGFBR1 |
0.746 | 0.191 | -2 | 0.781 |
BMPR1A |
0.746 | 0.228 | 1 | 0.763 |
CDC7 |
0.745 | 0.195 | 1 | 0.771 |
GRK6 |
0.745 | 0.290 | 1 | 0.659 |
CLK3 |
0.743 | 0.129 | 1 | 0.624 |
ACVR2B |
0.740 | 0.169 | -2 | 0.791 |
CAMK2G |
0.739 | 0.169 | 2 | 0.782 |
PRPK |
0.737 | 0.032 | -1 | 0.676 |
ACVR2A |
0.736 | 0.145 | -2 | 0.782 |
CAMK2B |
0.736 | 0.223 | 2 | 0.805 |
BMPR2 |
0.733 | -0.033 | -2 | 0.856 |
COT |
0.733 | 0.055 | 2 | 0.719 |
ALK4 |
0.730 | 0.085 | -2 | 0.806 |
CAMK2A |
0.728 | 0.167 | 2 | 0.802 |
PLK3 |
0.728 | 0.163 | 2 | 0.729 |
CAMK1B |
0.728 | 0.001 | -3 | 0.748 |
JNK3 |
0.728 | 0.081 | 1 | 0.500 |
LATS1 |
0.728 | 0.135 | -3 | 0.732 |
GRK5 |
0.727 | 0.090 | -3 | 0.752 |
JNK2 |
0.727 | 0.080 | 1 | 0.474 |
SKMLCK |
0.725 | 0.042 | -2 | 0.859 |
PDHK4 |
0.725 | -0.057 | 1 | 0.592 |
DSTYK |
0.725 | 0.010 | 2 | 0.773 |
RAF1 |
0.724 | -0.077 | 1 | 0.589 |
ATR |
0.723 | -0.033 | 1 | 0.509 |
ATM |
0.723 | 0.050 | 1 | 0.471 |
PLK2 |
0.723 | 0.156 | -3 | 0.802 |
DAPK2 |
0.722 | -0.015 | -3 | 0.747 |
ERK5 |
0.722 | -0.026 | 1 | 0.550 |
MARK4 |
0.721 | 0.038 | 4 | 0.726 |
IKKB |
0.721 | 0.037 | -2 | 0.734 |
PIM3 |
0.721 | 0.018 | -3 | 0.714 |
CAMLCK |
0.721 | -0.016 | -2 | 0.860 |
NLK |
0.720 | -0.067 | 1 | 0.578 |
IKKA |
0.720 | 0.113 | -2 | 0.713 |
MEK1 |
0.720 | -0.046 | 2 | 0.686 |
MTOR |
0.720 | -0.046 | 1 | 0.545 |
CAMK2D |
0.720 | 0.077 | -3 | 0.710 |
GRK4 |
0.719 | 0.059 | -2 | 0.831 |
JNK1 |
0.719 | 0.073 | 1 | 0.491 |
P38B |
0.718 | 0.053 | 1 | 0.478 |
CDKL1 |
0.718 | -0.042 | -3 | 0.674 |
MAPKAPK2 |
0.718 | 0.098 | -3 | 0.616 |
PASK |
0.717 | 0.066 | -3 | 0.727 |
NIK |
0.717 | -0.139 | -3 | 0.768 |
CDK1 |
0.717 | 0.024 | 1 | 0.499 |
PDHK1 |
0.716 | -0.108 | 1 | 0.572 |
RSK2 |
0.716 | 0.042 | -3 | 0.652 |
GRK2 |
0.716 | 0.040 | -2 | 0.730 |
DLK |
0.715 | -0.126 | 1 | 0.586 |
CLK2 |
0.715 | 0.092 | -3 | 0.642 |
IKKE |
0.714 | -0.065 | 1 | 0.490 |
TSSK2 |
0.714 | 0.020 | -5 | 0.781 |
PLK1 |
0.714 | 0.030 | -2 | 0.803 |
TBK1 |
0.714 | -0.088 | 1 | 0.479 |
CDK8 |
0.714 | 0.020 | 1 | 0.505 |
DYRK4 |
0.713 | 0.071 | 1 | 0.469 |
KIS |
0.712 | 0.062 | 1 | 0.498 |
PRKD1 |
0.712 | 0.031 | -3 | 0.699 |
DYRK2 |
0.712 | 0.025 | 1 | 0.492 |
ICK |
0.712 | -0.037 | -3 | 0.713 |
DNAPK |
0.711 | 0.046 | 1 | 0.380 |
PIM1 |
0.711 | 0.006 | -3 | 0.665 |
P38A |
0.711 | 0.015 | 1 | 0.492 |
HIPK4 |
0.711 | -0.015 | 1 | 0.516 |
HUNK |
0.710 | -0.089 | 2 | 0.642 |
NDR2 |
0.710 | 0.026 | -3 | 0.712 |
NUAK2 |
0.709 | -0.065 | -3 | 0.717 |
P38G |
0.709 | 0.030 | 1 | 0.438 |
P38D |
0.709 | 0.056 | 1 | 0.410 |
YSK4 |
0.708 | -0.109 | 1 | 0.531 |
GRK3 |
0.708 | 0.068 | -2 | 0.699 |
BRAF |
0.708 | -0.037 | -4 | 0.685 |
P90RSK |
0.708 | -0.006 | -3 | 0.659 |
PRP4 |
0.707 | -0.005 | -3 | 0.710 |
RSK4 |
0.707 | 0.052 | -3 | 0.617 |
GSK3A |
0.707 | 0.042 | 4 | 0.350 |
MARK2 |
0.707 | 0.033 | 4 | 0.671 |
CDK3 |
0.706 | 0.022 | 1 | 0.451 |
PKN3 |
0.706 | -0.072 | -3 | 0.689 |
SRPK1 |
0.706 | -0.018 | -3 | 0.637 |
TGFBR2 |
0.706 | -0.099 | -2 | 0.804 |
MSK1 |
0.705 | 0.053 | -3 | 0.627 |
MST4 |
0.705 | -0.084 | 2 | 0.671 |
AMPKA1 |
0.705 | -0.050 | -3 | 0.725 |
VRK2 |
0.705 | -0.300 | 1 | 0.566 |
MLK1 |
0.705 | -0.172 | 2 | 0.651 |
MARK3 |
0.705 | 0.032 | 4 | 0.684 |
MASTL |
0.704 | -0.206 | -2 | 0.782 |
CDK19 |
0.704 | 0.012 | 1 | 0.475 |
TLK2 |
0.704 | -0.072 | 1 | 0.477 |
ERK1 |
0.703 | 0.007 | 1 | 0.456 |
CLK4 |
0.703 | 0.009 | -3 | 0.662 |
MAPKAPK3 |
0.703 | -0.016 | -3 | 0.654 |
GCN2 |
0.703 | -0.177 | 2 | 0.649 |
CHK1 |
0.703 | -0.004 | -3 | 0.699 |
LATS2 |
0.703 | 0.010 | -5 | 0.605 |
CDK5 |
0.703 | -0.015 | 1 | 0.505 |
CHAK2 |
0.702 | -0.166 | -1 | 0.596 |
BCKDK |
0.702 | -0.083 | -1 | 0.598 |
MSK2 |
0.702 | 0.007 | -3 | 0.629 |
CDKL5 |
0.701 | -0.067 | -3 | 0.662 |
QSK |
0.701 | -0.006 | 4 | 0.709 |
MEKK3 |
0.701 | -0.133 | 1 | 0.523 |
PKR |
0.701 | -0.194 | 1 | 0.492 |
DRAK1 |
0.701 | -0.042 | 1 | 0.542 |
AURA |
0.700 | 0.050 | -2 | 0.698 |
MYLK4 |
0.700 | -0.007 | -2 | 0.805 |
CDK2 |
0.700 | -0.043 | 1 | 0.543 |
GAK |
0.700 | -0.057 | 1 | 0.527 |
MARK1 |
0.700 | 0.006 | 4 | 0.688 |
SMG1 |
0.700 | -0.055 | 1 | 0.446 |
TSSK1 |
0.700 | -0.042 | -3 | 0.736 |
PKCD |
0.699 | -0.081 | 2 | 0.637 |
TTBK2 |
0.699 | -0.100 | 2 | 0.550 |
CDK13 |
0.699 | -0.018 | 1 | 0.482 |
ERK2 |
0.699 | -0.025 | 1 | 0.479 |
ANKRD3 |
0.699 | -0.275 | 1 | 0.517 |
RIPK3 |
0.698 | -0.213 | 3 | 0.366 |
HIPK2 |
0.698 | 0.022 | 1 | 0.437 |
SRPK3 |
0.698 | -0.047 | -3 | 0.606 |
CDK17 |
0.698 | -0.002 | 1 | 0.434 |
GSK3B |
0.698 | -0.014 | 4 | 0.334 |
HIPK1 |
0.698 | -0.011 | 1 | 0.494 |
BRSK1 |
0.697 | -0.022 | -3 | 0.673 |
MLK3 |
0.697 | -0.117 | 2 | 0.609 |
TLK1 |
0.697 | -0.098 | -2 | 0.811 |
ULK2 |
0.697 | -0.235 | 2 | 0.612 |
AMPKA2 |
0.697 | -0.059 | -3 | 0.692 |
TAO3 |
0.697 | -0.110 | 1 | 0.529 |
WNK1 |
0.697 | -0.161 | -2 | 0.847 |
P70S6KB |
0.697 | -0.070 | -3 | 0.674 |
NEK6 |
0.697 | -0.167 | -2 | 0.828 |
CDK7 |
0.696 | -0.029 | 1 | 0.507 |
ALPHAK3 |
0.696 | 0.101 | -1 | 0.610 |
RSK3 |
0.695 | -0.045 | -3 | 0.650 |
PRKD2 |
0.695 | -0.032 | -3 | 0.647 |
NEK7 |
0.695 | -0.239 | -3 | 0.748 |
GCK |
0.695 | -0.092 | 1 | 0.525 |
CDK18 |
0.695 | -0.003 | 1 | 0.449 |
MST2 |
0.695 | -0.088 | 1 | 0.539 |
PKN2 |
0.695 | -0.127 | -3 | 0.717 |
MEKK2 |
0.695 | -0.190 | 2 | 0.626 |
MEK5 |
0.694 | -0.287 | 2 | 0.659 |
CAMK4 |
0.694 | -0.090 | -3 | 0.700 |
NDR1 |
0.694 | -0.101 | -3 | 0.713 |
PAK1 |
0.694 | -0.027 | -2 | 0.814 |
CDK12 |
0.693 | -0.018 | 1 | 0.463 |
TAK1 |
0.693 | -0.096 | 1 | 0.540 |
PKACB |
0.693 | 0.038 | -2 | 0.730 |
DYRK1B |
0.693 | 0.011 | 1 | 0.466 |
CLK1 |
0.693 | -0.018 | -3 | 0.643 |
SMMLCK |
0.693 | -0.059 | -3 | 0.692 |
CK1D |
0.692 | 0.006 | -3 | 0.479 |
MLK2 |
0.692 | -0.257 | 2 | 0.643 |
SRPK2 |
0.692 | -0.030 | -3 | 0.559 |
MLK4 |
0.692 | -0.144 | 2 | 0.588 |
DAPK3 |
0.691 | -0.008 | -3 | 0.688 |
RIPK1 |
0.691 | -0.262 | 1 | 0.445 |
MST3 |
0.691 | -0.140 | 2 | 0.658 |
EEF2K |
0.691 | -0.096 | 3 | 0.473 |
ZAK |
0.690 | -0.200 | 1 | 0.521 |
DYRK1A |
0.690 | -0.024 | 1 | 0.516 |
CDK16 |
0.690 | 0.001 | 1 | 0.442 |
DAPK1 |
0.690 | 0.006 | -3 | 0.669 |
PKACG |
0.690 | -0.036 | -2 | 0.778 |
QIK |
0.689 | -0.121 | -3 | 0.711 |
AURC |
0.689 | 0.009 | -2 | 0.722 |
NIM1 |
0.689 | -0.112 | 3 | 0.437 |
PERK |
0.689 | -0.198 | -2 | 0.824 |
CK1E |
0.689 | -0.010 | -3 | 0.527 |
CDK14 |
0.689 | -0.022 | 1 | 0.464 |
SIK |
0.688 | -0.046 | -3 | 0.649 |
NEK9 |
0.688 | -0.289 | 2 | 0.627 |
PRKX |
0.688 | 0.057 | -3 | 0.573 |
CAMKK1 |
0.687 | -0.162 | -2 | 0.747 |
HIPK3 |
0.687 | -0.044 | 1 | 0.473 |
MEKK1 |
0.687 | -0.251 | 1 | 0.492 |
WNK3 |
0.687 | -0.291 | 1 | 0.489 |
ULK1 |
0.687 | -0.210 | -3 | 0.723 |
CAMK1D |
0.687 | -0.016 | -3 | 0.582 |
TAO2 |
0.687 | -0.174 | 2 | 0.675 |
PRKD3 |
0.687 | -0.066 | -3 | 0.638 |
CDK9 |
0.686 | -0.043 | 1 | 0.479 |
PAK2 |
0.686 | -0.070 | -2 | 0.807 |
ERK7 |
0.686 | -0.043 | 2 | 0.411 |
DCAMKL1 |
0.686 | -0.091 | -3 | 0.677 |
DYRK3 |
0.685 | -0.011 | 1 | 0.483 |
TNIK |
0.685 | -0.128 | 3 | 0.472 |
SBK |
0.685 | 0.015 | -3 | 0.465 |
MPSK1 |
0.684 | -0.109 | 1 | 0.426 |
HPK1 |
0.684 | -0.116 | 1 | 0.509 |
PAK3 |
0.684 | -0.092 | -2 | 0.803 |
MAP3K15 |
0.684 | -0.185 | 1 | 0.495 |
LKB1 |
0.684 | -0.174 | -3 | 0.727 |
SSTK |
0.683 | -0.053 | 4 | 0.672 |
PIM2 |
0.683 | -0.071 | -3 | 0.625 |
DCAMKL2 |
0.683 | -0.098 | -3 | 0.705 |
AURB |
0.683 | -0.018 | -2 | 0.719 |
NEK2 |
0.683 | -0.194 | 2 | 0.605 |
SGK3 |
0.682 | -0.050 | -3 | 0.636 |
PINK1 |
0.682 | -0.210 | 1 | 0.498 |
MINK |
0.682 | -0.163 | 1 | 0.489 |
CK1A2 |
0.682 | -0.021 | -3 | 0.476 |
MNK1 |
0.682 | -0.066 | -2 | 0.812 |
NEK11 |
0.682 | -0.247 | 1 | 0.497 |
PKCA |
0.681 | -0.103 | 2 | 0.575 |
MAK |
0.681 | 0.007 | -2 | 0.750 |
BRSK2 |
0.681 | -0.100 | -3 | 0.696 |
PKCG |
0.681 | -0.114 | 2 | 0.599 |
MST1 |
0.681 | -0.155 | 1 | 0.505 |
AKT2 |
0.681 | -0.051 | -3 | 0.576 |
TTBK1 |
0.681 | -0.102 | 2 | 0.501 |
CAMKK2 |
0.681 | -0.175 | -2 | 0.741 |
HRI |
0.681 | -0.266 | -2 | 0.829 |
PLK4 |
0.680 | -0.135 | 2 | 0.501 |
NUAK1 |
0.680 | -0.111 | -3 | 0.669 |
HGK |
0.680 | -0.175 | 3 | 0.452 |
NEK8 |
0.679 | -0.266 | 2 | 0.639 |
ASK1 |
0.679 | -0.119 | 1 | 0.506 |
KHS1 |
0.679 | -0.117 | 1 | 0.485 |
NEK5 |
0.679 | -0.298 | 1 | 0.455 |
PDK1 |
0.679 | -0.182 | 1 | 0.471 |
MNK2 |
0.678 | -0.076 | -2 | 0.803 |
PKACA |
0.678 | 0.019 | -2 | 0.680 |
PKG2 |
0.677 | -0.034 | -2 | 0.726 |
PKCB |
0.677 | -0.125 | 2 | 0.582 |
KHS2 |
0.677 | -0.106 | 1 | 0.496 |
PKCH |
0.676 | -0.142 | 2 | 0.565 |
CAMK1G |
0.676 | -0.106 | -3 | 0.635 |
MEK2 |
0.676 | -0.211 | 2 | 0.620 |
LRRK2 |
0.676 | -0.252 | 2 | 0.669 |
CDK10 |
0.676 | -0.032 | 1 | 0.447 |
BUB1 |
0.676 | -0.023 | -5 | 0.757 |
MEKK6 |
0.675 | -0.250 | 1 | 0.504 |
VRK1 |
0.675 | -0.276 | 2 | 0.635 |
PAK6 |
0.674 | -0.021 | -2 | 0.740 |
CDK6 |
0.674 | -0.048 | 1 | 0.440 |
MAPKAPK5 |
0.674 | -0.123 | -3 | 0.587 |
MELK |
0.673 | -0.177 | -3 | 0.679 |
CDK4 |
0.672 | -0.045 | 1 | 0.456 |
CHAK1 |
0.672 | -0.301 | 2 | 0.577 |
IRE1 |
0.672 | -0.288 | 1 | 0.415 |
IRE2 |
0.671 | -0.242 | 2 | 0.572 |
WNK4 |
0.671 | -0.253 | -2 | 0.831 |
SNRK |
0.671 | -0.219 | 2 | 0.557 |
YANK3 |
0.670 | -0.039 | 2 | 0.399 |
NEK4 |
0.670 | -0.278 | 1 | 0.440 |
SLK |
0.669 | -0.151 | -2 | 0.711 |
OSR1 |
0.669 | -0.161 | 2 | 0.604 |
NEK1 |
0.668 | -0.268 | 1 | 0.439 |
CK1G1 |
0.668 | -0.052 | -3 | 0.541 |
PKCZ |
0.668 | -0.194 | 2 | 0.593 |
MRCKA |
0.668 | -0.060 | -3 | 0.640 |
SGK1 |
0.667 | -0.025 | -3 | 0.501 |
RIPK2 |
0.667 | -0.234 | 1 | 0.472 |
DMPK1 |
0.667 | -0.037 | -3 | 0.647 |
AKT1 |
0.667 | -0.058 | -3 | 0.590 |
ROCK2 |
0.666 | -0.074 | -3 | 0.671 |
TTK |
0.666 | -0.143 | -2 | 0.827 |
CAMK1A |
0.666 | -0.054 | -3 | 0.556 |
BIKE |
0.666 | -0.089 | 1 | 0.400 |
MOK |
0.665 | -0.059 | 1 | 0.463 |
YSK1 |
0.665 | -0.209 | 2 | 0.607 |
PBK |
0.664 | -0.145 | 1 | 0.438 |
MRCKB |
0.664 | -0.067 | -3 | 0.619 |
PHKG1 |
0.664 | -0.211 | -3 | 0.710 |
CHK2 |
0.663 | -0.093 | -3 | 0.536 |
LOK |
0.663 | -0.216 | -2 | 0.757 |
PDHK3_TYR |
0.662 | 0.286 | 4 | 0.731 |
IRAK1 |
0.662 | -0.301 | -1 | 0.519 |
PKCT |
0.661 | -0.151 | 2 | 0.566 |
P70S6K |
0.661 | -0.118 | -3 | 0.581 |
PKCE |
0.661 | -0.107 | 2 | 0.576 |
IRAK4 |
0.660 | -0.321 | 1 | 0.411 |
PKCI |
0.656 | -0.164 | 2 | 0.565 |
MYO3A |
0.656 | -0.193 | 1 | 0.445 |
STLK3 |
0.655 | -0.184 | 1 | 0.496 |
MAP2K6_TYR |
0.655 | 0.188 | -1 | 0.682 |
PDHK4_TYR |
0.655 | 0.188 | 2 | 0.786 |
AAK1 |
0.655 | -0.056 | 1 | 0.311 |
TAO1 |
0.654 | -0.197 | 1 | 0.449 |
PHKG2 |
0.653 | -0.180 | -3 | 0.684 |
PDHK1_TYR |
0.652 | 0.143 | -1 | 0.684 |
EPHA4 |
0.652 | 0.140 | 2 | 0.750 |
PAK5 |
0.652 | -0.060 | -2 | 0.699 |
HASPIN |
0.652 | -0.140 | -1 | 0.484 |
TXK |
0.652 | 0.111 | 1 | 0.708 |
MYO3B |
0.651 | -0.213 | 2 | 0.632 |
AKT3 |
0.651 | -0.057 | -3 | 0.520 |
MAP2K4_TYR |
0.651 | 0.131 | -1 | 0.702 |
CRIK |
0.650 | -0.084 | -3 | 0.577 |
STK33 |
0.650 | -0.218 | 2 | 0.527 |
BMPR2_TYR |
0.649 | 0.089 | -1 | 0.700 |
ROCK1 |
0.649 | -0.092 | -3 | 0.638 |
PKN1 |
0.649 | -0.133 | -3 | 0.604 |
SRMS |
0.646 | 0.109 | 1 | 0.685 |
CK1A |
0.646 | -0.024 | -3 | 0.409 |
PAK4 |
0.646 | -0.055 | -2 | 0.704 |
EPHA6 |
0.645 | 0.055 | -1 | 0.674 |
MAP2K7_TYR |
0.644 | 0.030 | 2 | 0.737 |
TESK1_TYR |
0.643 | -0.054 | 3 | 0.522 |
NEK3 |
0.643 | -0.314 | 1 | 0.430 |
SYK |
0.642 | 0.133 | -1 | 0.633 |
FER |
0.642 | 0.049 | 1 | 0.675 |
FYN |
0.641 | 0.071 | -1 | 0.669 |
CK1G3 |
0.641 | -0.032 | -3 | 0.368 |
EPHB2 |
0.640 | 0.073 | -1 | 0.641 |
YANK2 |
0.640 | -0.067 | 2 | 0.419 |
PTK2 |
0.639 | 0.095 | -1 | 0.670 |
EPHB4 |
0.639 | 0.020 | -1 | 0.660 |
PKMYT1_TYR |
0.637 | -0.097 | 3 | 0.486 |
EPHA5 |
0.637 | 0.098 | 2 | 0.753 |
EPHB1 |
0.635 | 0.015 | 1 | 0.665 |
YES1 |
0.634 | -0.020 | -1 | 0.674 |
INSRR |
0.634 | -0.027 | 3 | 0.372 |
EPHB3 |
0.634 | 0.017 | -1 | 0.633 |
HCK |
0.633 | -0.042 | -1 | 0.662 |
EPHA7 |
0.633 | 0.034 | 2 | 0.723 |
EGFR |
0.632 | 0.040 | 1 | 0.512 |
BMX |
0.632 | 0.001 | -1 | 0.596 |
PINK1_TYR |
0.632 | -0.167 | 1 | 0.575 |
PKG1 |
0.631 | -0.075 | -2 | 0.659 |
EPHA3 |
0.631 | 0.002 | 2 | 0.717 |
MERTK |
0.631 | -0.020 | 3 | 0.409 |
CK1G2 |
0.630 | -0.038 | -3 | 0.458 |
LCK |
0.630 | -0.038 | -1 | 0.662 |
PTK2B |
0.630 | -0.000 | -1 | 0.598 |
ITK |
0.629 | -0.044 | -1 | 0.623 |
BLK |
0.629 | -0.009 | -1 | 0.656 |
FGFR2 |
0.628 | -0.071 | 3 | 0.412 |
EPHA8 |
0.628 | 0.009 | -1 | 0.618 |
TEC |
0.627 | -0.035 | -1 | 0.596 |
FGR |
0.627 | -0.101 | 1 | 0.558 |
CSF1R |
0.627 | -0.137 | 3 | 0.400 |
LYN |
0.626 | -0.030 | 3 | 0.355 |
EPHA2 |
0.626 | 0.034 | -1 | 0.622 |
RET |
0.625 | -0.170 | 1 | 0.511 |
TYRO3 |
0.625 | -0.168 | 3 | 0.400 |
FGFR3 |
0.625 | -0.053 | 3 | 0.393 |
MST1R |
0.625 | -0.212 | 3 | 0.416 |
LIMK2_TYR |
0.625 | -0.163 | -3 | 0.770 |
SRC |
0.624 | -0.021 | -1 | 0.659 |
ABL2 |
0.624 | -0.096 | -1 | 0.616 |
KIT |
0.624 | -0.115 | 3 | 0.401 |
JAK3 |
0.624 | -0.135 | 1 | 0.528 |
JAK2 |
0.623 | -0.196 | 1 | 0.514 |
ERBB4 |
0.623 | 0.014 | 1 | 0.564 |
TYK2 |
0.622 | -0.223 | 1 | 0.506 |
NTRK1 |
0.622 | -0.089 | -1 | 0.643 |
FGFR4 |
0.622 | -0.012 | -1 | 0.606 |
DDR1 |
0.622 | -0.136 | 4 | 0.633 |
ERBB2 |
0.622 | -0.087 | 1 | 0.553 |
FRK |
0.621 | -0.065 | -1 | 0.646 |
TEK |
0.621 | -0.118 | 3 | 0.351 |
ABL1 |
0.621 | -0.120 | -1 | 0.613 |
LIMK1_TYR |
0.621 | -0.236 | 2 | 0.688 |
ROS1 |
0.620 | -0.209 | 3 | 0.368 |
BTK |
0.620 | -0.111 | -1 | 0.600 |
FGFR1 |
0.620 | -0.133 | 3 | 0.385 |
FLT1 |
0.619 | -0.078 | -1 | 0.651 |
LTK |
0.617 | -0.107 | 3 | 0.371 |
FLT3 |
0.617 | -0.173 | 3 | 0.393 |
CSK |
0.617 | -0.057 | 2 | 0.715 |
EPHA1 |
0.616 | -0.099 | 3 | 0.367 |
NTRK3 |
0.616 | -0.090 | -1 | 0.605 |
MET |
0.616 | -0.124 | 3 | 0.393 |
INSR |
0.615 | -0.108 | 3 | 0.357 |
AXL |
0.615 | -0.142 | 3 | 0.383 |
ALK |
0.615 | -0.137 | 3 | 0.341 |
PTK6 |
0.613 | -0.126 | -1 | 0.562 |
IGF1R |
0.613 | -0.058 | 3 | 0.323 |
NEK10_TYR |
0.612 | -0.139 | 1 | 0.449 |
KDR |
0.612 | -0.179 | 3 | 0.370 |
JAK1 |
0.611 | -0.168 | 1 | 0.470 |
TNK2 |
0.610 | -0.180 | 3 | 0.360 |
FLT4 |
0.609 | -0.162 | 3 | 0.387 |
PDGFRB |
0.609 | -0.238 | 3 | 0.396 |
NTRK2 |
0.608 | -0.180 | 3 | 0.370 |
FES |
0.608 | -0.050 | -1 | 0.575 |
MATK |
0.608 | -0.102 | -1 | 0.537 |
ZAP70 |
0.605 | -0.012 | -1 | 0.571 |
WEE1_TYR |
0.603 | -0.166 | -1 | 0.579 |
PDGFRA |
0.602 | -0.285 | 3 | 0.393 |
DDR2 |
0.600 | -0.094 | 3 | 0.346 |
TNNI3K_TYR |
0.598 | -0.194 | 1 | 0.490 |
TNK1 |
0.597 | -0.241 | 3 | 0.402 |
MUSK |
0.589 | -0.178 | 1 | 0.465 |