Motif 1185 (n=50)

Position-wise Probabilities

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uniprot genes site source protein function
A0A096LP55 UQCRHL T11 ochoa Cytochrome b-c1 complex subunit 6-like, mitochondrial May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}.
A2RU30 TESPA1 T9 ochoa Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}.
B5ME19 EIF3CL S9 ochoa Eukaryotic translation initiation factor 3 subunit C-like protein Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}.
O43294 TGFB1I1 S9 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43776 NARS1 S9 ochoa Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}.
P02730 SLC4A1 Y8 psp Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}.
P07919 UQCRH T11 ochoa Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}.
P17480 UBTF T9 ochoa Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.
P18615 NELFE S9 ochoa Negative elongation factor E (NELF-E) (RNA-binding protein RD) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
P28347 TEAD1 S9 ochoa Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
P30153 PPP2R1A S9 ochoa Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:8694763}.
P31321 PRKAR1B S9 ochoa cAMP-dependent protein kinase type I-beta regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}.
P40855 PEX19 S9 ochoa Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}.
P47755 CAPZA2 S9 ochoa F-actin-capping protein subunit alpha-2 (CapZ alpha-2) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
P49810 PSEN2 S9 psp Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}.
P52907 CAPZA1 S9 ochoa|psp F-actin-capping protein subunit alpha-1 (CapZ alpha-1) F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}.
P54619 PRKAG1 S9 ochoa 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:21680840, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:21680840, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:21680840, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:21680840, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:21680840, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:21680840, PubMed:24563466). {ECO:0000269|PubMed:21680840, ECO:0000269|PubMed:24563466}.
P61457 PCBD1 S9 ochoa Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001). {ECO:0000250|UniProtKB:P61459, ECO:0000269|PubMed:24204001}.
P62316 SNRPD2 S9 ochoa Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}.
P63165 SUMO1 S9 ochoa Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.
P78362 SRPK2 S9 ochoa SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.
Q15311 RALBP1 T9 ochoa RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.
Q16667 CDKN3 T9 ochoa Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}.
Q4V339 ZNG1F S7 ochoa Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). {ECO:0000250|UniProtKB:Q8VEH6, ECO:0000269|PubMed:35584702}.
Q5JTY5 ZNG1C S7 ochoa Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q5RIA9 ZNG1E S7 ochoa Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q5SYC1 CLVS2 S9 ochoa Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2) Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}.
Q6ZW76 ANKS3 S9 ochoa Ankyrin repeat and SAM domain-containing protein 3 May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}.
Q86SQ7 SDCCAG8 T9 ochoa Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}.
Q8IYB3 SRRM1 T9 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IYE0 CCDC146 T8 ochoa Coiled-coil domain-containing protein 146 Essential for sperm flagellum biogenesis and male fertility. {ECO:0000250|UniProtKB:E9Q9F7}.
Q8N3U4 STAG2 T9 ochoa Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}.
Q969F1 GTF3C6 S9 ochoa General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}.
Q96DU7 ITPKC S9 ochoa Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}.
Q99613 EIF3C S9 ochoa Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
Q9BRT8 ZNG1A S7 ochoa Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6) Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1A to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
Q9H0S4 DDX47 S9 ochoa Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068). {ECO:0000250|UniProtKB:Q9VIF6, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}.
Q9H813 PACC1 S9 ochoa Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}.
Q9NVA2 SEPTIN11 S9 ochoa Septin-11 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.
Q9NWV8 BABAM1 S8 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9NWV8 BABAM1 T10 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9NXR1 NDE1 S9 ochoa Nuclear distribution protein nudE homolog 1 (NudE) Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}.
Q9NZT2 OGFR T9 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9P215 POGK S11 ochoa Pogo transposable element with KRAB domain None
Q9ULJ1 ODF2L S9 ochoa Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) (ODF2-like protein) Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. {ECO:0000269|PubMed:28775150}.
Q9Y2J2 EPB41L3 S9 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
P62906 RPL10A T9 Sugiyama Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
P61024 CKS1B S9 Sugiyama Cyclin-dependent kinases regulatory subunit 1 (CKS-1) Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
P13693 TPT1 S9 Sugiyama Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}.
Q9UKG9 CROT T9 Sugiyama Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269|PubMed:10486279}.
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reactome_id name p -log10_p
R-HSA-5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... 0.009457 2.024
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 0.028109 1.551
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 0.031184 1.506
R-HSA-2470946 Cohesin Loading onto Chromatin 0.031184 1.506
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.040352 1.394
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.043389 1.363
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.043389 1.363
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.043389 1.363
R-HSA-5339716 Signaling by GSK3beta mutants 0.046417 1.333
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.049435 1.306
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.049435 1.306
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.049435 1.306
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.049435 1.306
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.049435 1.306
R-HSA-196299 Beta-catenin phosphorylation cascade 0.058434 1.233
R-HSA-9603798 Class I peroxisomal membrane protein import 0.061415 1.212
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.001524 2.817
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.001524 2.817
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.073246 1.135
R-HSA-8854518 AURKA Activation by TPX2 0.001714 2.766
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.002213 2.655
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.082024 1.086
R-HSA-380287 Centrosome maturation 0.002371 2.625
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.003668 2.436
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.099335 1.003
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.099335 1.003
R-HSA-73728 RNA Polymerase I Promoter Opening 0.099335 1.003
R-HSA-167287 HIV elongation arrest and recovery 0.102189 0.991
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.102189 0.991
R-HSA-167290 Pausing and recovery of HIV elongation 0.102189 0.991
R-HSA-72689 Formation of a pool of free 40S subunits 0.004693 2.329
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.006601 2.180
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.007220 2.141
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.007220 2.141
R-HSA-141424 Amplification of signal from the kinetochores 0.035972 1.444
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.035972 1.444
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.040228 1.395
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.040955 1.388
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.043914 1.357
R-HSA-192823 Viral mRNA Translation 0.050850 1.294
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.054863 1.261
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.003883 2.411
R-HSA-389513 Co-inhibition by CTLA4 0.076181 1.118
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.084931 1.071
R-HSA-156902 Peptide chain elongation 0.038077 1.419
R-HSA-9948299 Ribosome-associated quality control 0.086712 1.062
R-HSA-73863 RNA Polymerase I Transcription Termination 0.099335 1.003
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.107870 0.967
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.022161 1.654
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.044666 1.350
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.006601 2.180
R-HSA-1295596 Spry regulation of FGF signaling 0.058434 1.233
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.107870 0.967
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.009093 2.041
R-HSA-72764 Eukaryotic Translation Termination 0.044666 1.350
R-HSA-72613 Eukaryotic Translation Initiation 0.008210 2.086
R-HSA-69618 Mitotic Spindle Checkpoint 0.048496 1.314
R-HSA-72737 Cap-dependent Translation Initiation 0.008210 2.086
R-HSA-9017802 Noncanonical activation of NOTCH3 0.025025 1.602
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.034250 1.465
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.040352 1.394
R-HSA-4839744 Signaling by APC mutants 0.043389 1.363
R-HSA-9865881 Complex III assembly 0.004165 2.380
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.046417 1.333
R-HSA-202670 ERKs are inactivated 0.046417 1.333
R-HSA-4839748 Signaling by AMER1 mutants 0.046417 1.333
R-HSA-4839735 Signaling by AXIN mutants 0.046417 1.333
R-HSA-163615 PKA activation 0.070302 1.153
R-HSA-164378 PKA activation in glucagon signalling 0.070302 1.153
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.102189 0.991
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.105034 0.979
R-HSA-4791275 Signaling by WNT in cancer 0.113516 0.945
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.121920 0.914
R-HSA-74158 RNA Polymerase III Transcription 0.127478 0.895
R-HSA-68877 Mitotic Prometaphase 0.004588 2.338
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.116326 0.934
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.127478 0.895
R-HSA-156842 Eukaryotic Translation Elongation 0.041688 1.380
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.102189 0.991
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.027991 1.553
R-HSA-2467813 Separation of Sister Chromatids 0.020094 1.697
R-HSA-9839383 TGFBR3 PTM regulation 0.034250 1.465
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.046417 1.333
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 0.052444 1.280
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.055444 1.256
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.003165 2.500
R-HSA-5689901 Metalloprotease DUBs 0.096472 1.016
R-HSA-113418 Formation of the Early Elongation Complex 0.102189 0.991
R-HSA-72766 Translation 0.054010 1.268
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.079107 1.102
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.082024 1.086
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.017189 1.765
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.099335 1.003
R-HSA-2408557 Selenocysteine synthesis 0.049276 1.307
R-HSA-72312 rRNA processing 0.045787 1.339
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.001219 2.914
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.037306 1.428
R-HSA-425381 Bicarbonate transporters 0.043389 1.363
R-HSA-877312 Regulation of IFNG signaling 0.049435 1.306
R-HSA-180024 DARPP-32 events 0.005612 2.251
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 0.061415 1.212
R-HSA-113510 E2F mediated regulation of DNA replication 0.073246 1.135
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.051644 1.287
R-HSA-69236 G1 Phase 0.011971 1.922
R-HSA-69231 Cyclin D associated events in G1 0.011971 1.922
R-HSA-68886 M Phase 0.008872 2.052
R-HSA-9613354 Lipophagy 0.037306 1.428
R-HSA-193692 Regulated proteolysis of p75NTR 0.037306 1.428
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 0.037306 1.428
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.056499 1.248
R-HSA-68882 Mitotic Anaphase 0.006667 2.176
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.006765 2.170
R-HSA-8953854 Metabolism of RNA 0.052564 1.279
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.124703 0.904
R-HSA-69275 G2/M Transition 0.027307 1.564
R-HSA-9609507 Protein localization 0.102286 0.990
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.049435 1.306
R-HSA-8964208 Phenylalanine metabolism 0.079107 1.102
R-HSA-163359 Glucagon signaling in metabolic regulation 0.119127 0.924
R-HSA-5673000 RAF activation 0.121920 0.914
R-HSA-6807878 COPI-mediated anterograde transport 0.045422 1.343
R-HSA-453274 Mitotic G2-G2/M phases 0.027991 1.553
R-HSA-5617833 Cilium Assembly 0.028685 1.542
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.079107 1.102
R-HSA-9659379 Sensory processing of sound 0.002706 2.568
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.019286 1.715
R-HSA-69242 S Phase 0.097337 1.012
R-HSA-9694631 Maturation of nucleoprotein 0.002698 2.569
R-HSA-205043 NRIF signals cell death from the nucleus 0.055444 1.256
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.073246 1.135
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.001848 2.733
R-HSA-198753 ERK/MAPK targets 0.079107 1.102
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.096472 1.016
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.104284 0.982
R-HSA-9711097 Cellular response to starvation 0.107303 0.969
R-HSA-69278 Cell Cycle, Mitotic 0.010367 1.984
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.084931 1.071
R-HSA-1640170 Cell Cycle 0.007839 2.106
R-HSA-438064 Post NMDA receptor activation events 0.037370 1.427
R-HSA-611105 Respiratory electron transport 0.129056 0.889
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.073246 1.135
R-HSA-5693606 DNA Double Strand Break Response 0.023783 1.624
R-HSA-432720 Lysosome Vesicle Biogenesis 0.127478 0.895
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.031905 1.496
R-HSA-9860931 Response of endothelial cells to shear stress 0.051644 1.287
R-HSA-9683610 Maturation of nucleoprotein 0.052444 1.280
R-HSA-432142 Platelet sensitization by LDL 0.070302 1.153
R-HSA-8856688 Golgi-to-ER retrograde transport 0.080149 1.096
R-HSA-1852241 Organelle biogenesis and maintenance 0.022616 1.646
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.096472 1.016
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.101290 0.994
R-HSA-388841 Regulation of T cell activation by CD28 family 0.057104 1.243
R-HSA-9855142 Cellular responses to mechanical stimuli 0.060663 1.217
R-HSA-69620 Cell Cycle Checkpoints 0.058102 1.236
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.023706 1.625
R-HSA-1369062 ABC transporters in lipid homeostasis 0.087830 1.056
R-HSA-389887 Beta-oxidation of pristanoyl-CoA 0.093600 1.029
R-HSA-1980145 Signaling by NOTCH2 0.121920 0.914
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.095378 1.021
R-HSA-111933 Calmodulin induced events 0.127478 0.895
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.116326 0.934
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.116326 0.934
R-HSA-111997 CaM pathway 0.127478 0.895
R-HSA-163685 Integration of energy metabolism 0.084820 1.072
R-HSA-69206 G1/S Transition 0.072855 1.138
R-HSA-5693532 DNA Double-Strand Break Repair 0.102286 0.990
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.119127 0.924
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.050061 1.301
R-HSA-6804757 Regulation of TP53 Degradation 0.127478 0.895
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.105034 0.979
R-HSA-2408522 Selenoamino acid metabolism 0.113410 0.945
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.122736 0.911
R-HSA-199977 ER to Golgi Anterograde Transport 0.096356 1.016
R-HSA-111885 Opioid Signalling 0.051644 1.287
R-HSA-9833482 PKR-mediated signaling 0.031905 1.496
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.024373 1.613
R-HSA-9694635 Translation of Structural Proteins 0.029945 1.524
R-HSA-2132295 MHC class II antigen presentation 0.070179 1.154
R-HSA-168255 Influenza Infection 0.130117 0.886
R-HSA-5633007 Regulation of TP53 Activity 0.109328 0.961
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.041688 1.380
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.103284 0.986
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.022622 1.645
R-HSA-9020591 Interleukin-12 signaling 0.029303 1.533
R-HSA-9675108 Nervous system development 0.123343 0.909
R-HSA-9694516 SARS-CoV-2 Infection 0.111721 0.952
R-HSA-447115 Interleukin-12 family signaling 0.037370 1.427
R-HSA-8963691 Phenylalanine and tyrosine metabolism 0.130245 0.885
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.133003 0.876
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.135752 0.867
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.135752 0.867
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.138493 0.859
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.138493 0.859
R-HSA-167169 HIV Transcription Elongation 0.138493 0.859
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.138493 0.859
R-HSA-1251985 Nuclear signaling by ERBB4 0.138493 0.859
R-HSA-5675221 Negative regulation of MAPK pathway 0.143949 0.842
R-HSA-9683701 Translation of Structural Proteins 0.143949 0.842
R-HSA-72163 mRNA Splicing - Major Pathway 0.146269 0.835
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.146664 0.834
R-HSA-165159 MTOR signalling 0.146664 0.834
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.146664 0.834
R-HSA-111996 Ca-dependent events 0.146664 0.834
R-HSA-379716 Cytosolic tRNA aminoacylation 0.146664 0.834
R-HSA-5654743 Signaling by FGFR4 0.149371 0.826
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.152069 0.818
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.152069 0.818
R-HSA-389948 Co-inhibition by PD-1 0.152845 0.816
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.152845 0.816
R-HSA-9824446 Viral Infection Pathways 0.153643 0.813
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.154759 0.810
R-HSA-5654741 Signaling by FGFR3 0.154759 0.810
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.154759 0.810
R-HSA-1489509 DAG and IP3 signaling 0.154759 0.810
R-HSA-948021 Transport to the Golgi and subsequent modification 0.155050 0.810
R-HSA-376176 Signaling by ROBO receptors 0.156155 0.806
R-HSA-72165 mRNA Splicing - Minor Pathway 0.157441 0.803
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.157441 0.803
R-HSA-9839373 Signaling by TGFBR3 0.157441 0.803
R-HSA-72172 mRNA Splicing 0.158370 0.800
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.160114 0.796
R-HSA-199991 Membrane Trafficking 0.161293 0.792
R-HSA-8953897 Cellular responses to stimuli 0.161715 0.791
R-HSA-9634597 GPER1 signaling 0.162779 0.788
R-HSA-389356 Co-stimulation by CD28 0.162779 0.788
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.162779 0.788
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.167288 0.777
R-HSA-72187 mRNA 3'-end processing 0.173356 0.761
R-HSA-73772 RNA Polymerase I Promoter Escape 0.173356 0.761
R-HSA-112382 Formation of RNA Pol II elongation complex 0.173356 0.761
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.173356 0.761
R-HSA-6794361 Neurexins and neuroligins 0.173356 0.761
R-HSA-1221632 Meiotic synapsis 0.175980 0.755
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.175980 0.755
R-HSA-72649 Translation initiation complex formation 0.178596 0.748
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.178596 0.748
R-HSA-9012852 Signaling by NOTCH3 0.181203 0.742
R-HSA-72702 Ribosomal scanning and start codon recognition 0.183803 0.736
R-HSA-5654736 Signaling by FGFR1 0.183803 0.736
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.183803 0.736
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.188977 0.724
R-HSA-191859 snRNP Assembly 0.191552 0.718
R-HSA-194441 Metabolism of non-coding RNA 0.191552 0.718
R-HSA-9033241 Peroxisomal protein import 0.191552 0.718
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.194119 0.712
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.194119 0.712
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.194119 0.712
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.194119 0.712
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.194119 0.712
R-HSA-379724 tRNA Aminoacylation 0.194119 0.712
R-HSA-73856 RNA Polymerase II Transcription Termination 0.196678 0.706
R-HSA-445717 Aquaporin-mediated transport 0.196678 0.706
R-HSA-112043 PLC beta mediated events 0.196678 0.706
R-HSA-450294 MAP kinase activation 0.196678 0.706
R-HSA-3700989 Transcriptional Regulation by TP53 0.199226 0.701
R-HSA-112316 Neuronal System 0.201665 0.695
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.201773 0.695
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.209355 0.679
R-HSA-112040 G-protein mediated events 0.211867 0.674
R-HSA-167172 Transcription of the HIV genome 0.214371 0.669
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.219355 0.659
R-HSA-69202 Cyclin E associated events during G1/S transition 0.219355 0.659
R-HSA-448424 Interleukin-17 signaling 0.219355 0.659
R-HSA-427413 NoRC negatively regulates rRNA expression 0.221836 0.654
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.221836 0.654
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.224309 0.649
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.224309 0.649
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.224309 0.649
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.226774 0.644
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.226774 0.644
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.226774 0.644
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.229231 0.640
R-HSA-69473 G2/M DNA damage checkpoint 0.229231 0.640
R-HSA-9013694 Signaling by NOTCH4 0.229231 0.640
R-HSA-1236394 Signaling by ERBB4 0.229231 0.640
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.234123 0.631
R-HSA-1980143 Signaling by NOTCH1 0.234123 0.631
R-HSA-73864 RNA Polymerase I Transcription 0.238984 0.622
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.238984 0.622
R-HSA-5654738 Signaling by FGFR2 0.243816 0.613
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.243816 0.613
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.243816 0.613
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.244546 0.612
R-HSA-5693607 Processing of DNA double-strand break ends 0.246220 0.609
R-HSA-1280218 Adaptive Immune System 0.247891 0.606
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.248617 0.604
R-HSA-109582 Hemostasis 0.250481 0.601
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.253388 0.596
R-HSA-390918 Peroxisomal lipid metabolism 0.253388 0.596
R-HSA-1500620 Meiosis 0.255763 0.592
R-HSA-6794362 Protein-protein interactions at synapses 0.255763 0.592
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.258130 0.588
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.260489 0.584
R-HSA-9663891 Selective autophagy 0.265187 0.576
R-HSA-422475 Axon guidance 0.266360 0.575
R-HSA-5653656 Vesicle-mediated transport 0.267317 0.573
R-HSA-9679506 SARS-CoV Infections 0.274983 0.561
R-HSA-2682334 EPH-Ephrin signaling 0.276802 0.558
R-HSA-8878159 Transcriptional regulation by RUNX3 0.290504 0.537
R-HSA-74160 Gene expression (Transcription) 0.291569 0.535
R-HSA-190236 Signaling by FGFR 0.292763 0.533
R-HSA-422356 Regulation of insulin secretion 0.292763 0.533
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.292763 0.533
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.292763 0.533
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.292763 0.533
R-HSA-193704 p75 NTR receptor-mediated signalling 0.295014 0.530
R-HSA-112315 Transmission across Chemical Synapses 0.296288 0.528
R-HSA-5663205 Infectious disease 0.296382 0.528
R-HSA-70171 Glycolysis 0.297259 0.527
R-HSA-382556 ABC-family proteins mediated transport 0.297259 0.527
R-HSA-5610787 Hedgehog 'off' state 0.297259 0.527
R-HSA-5696398 Nucleotide Excision Repair 0.310580 0.508
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.310580 0.508
R-HSA-418346 Platelet homeostasis 0.312776 0.505
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.317148 0.499
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.317382 0.498
R-HSA-9006925 Intracellular signaling by second messengers 0.318550 0.497
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.319323 0.496
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.321492 0.493
R-HSA-166166 MyD88-independent TLR4 cascade 0.321492 0.493
R-HSA-1483249 Inositol phosphate metabolism 0.325809 0.487
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.327957 0.484
R-HSA-71291 Metabolism of amino acids and derivatives 0.329856 0.482
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.330099 0.481
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.334363 0.476
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.334363 0.476
R-HSA-449147 Signaling by Interleukins 0.335980 0.474
R-HSA-73894 DNA Repair 0.339507 0.469
R-HSA-1592230 Mitochondrial biogenesis 0.340708 0.468
R-HSA-70326 Glucose metabolism 0.340708 0.468
R-HSA-5693538 Homology Directed Repair 0.342810 0.465
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.344905 0.462
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.344905 0.462
R-HSA-68875 Mitotic Prophase 0.346994 0.460
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.351152 0.455
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.351152 0.455
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.353221 0.452
R-HSA-392499 Metabolism of proteins 0.361196 0.442
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.361433 0.442
R-HSA-69481 G2/M Checkpoints 0.363470 0.440
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.365501 0.437
R-HSA-913531 Interferon Signaling 0.367158 0.435
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.369544 0.432
R-HSA-1474165 Reproduction 0.371555 0.430
R-HSA-9018519 Estrogen-dependent gene expression 0.385462 0.414
R-HSA-5358351 Signaling by Hedgehog 0.389380 0.410
R-HSA-418594 G alpha (i) signalling events 0.394384 0.404
R-HSA-1632852 Macroautophagy 0.395210 0.403
R-HSA-162599 Late Phase of HIV Life Cycle 0.399067 0.399
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.410493 0.387
R-HSA-166520 Signaling by NTRKs 0.410493 0.387
R-HSA-446203 Asparagine N-linked glycosylation 0.411147 0.386
R-HSA-1643685 Disease 0.417831 0.379
R-HSA-2262752 Cellular responses to stress 0.419693 0.377
R-HSA-73887 Death Receptor Signaling 0.421706 0.375
R-HSA-9612973 Autophagy 0.425397 0.371
R-HSA-162587 HIV Life Cycle 0.427234 0.369
R-HSA-877300 Interferon gamma signaling 0.430890 0.366
R-HSA-9006936 Signaling by TGFB family members 0.432710 0.364
R-HSA-5619102 SLC transporter disorders 0.445289 0.351
R-HSA-418555 G alpha (s) signalling events 0.454105 0.343
R-HSA-9664433 Leishmania parasite growth and survival 0.457594 0.340
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.457594 0.340
R-HSA-1280215 Cytokine Signaling in Immune system 0.459995 0.337
R-HSA-9678108 SARS-CoV-1 Infection 0.461060 0.336
R-HSA-73857 RNA Polymerase II Transcription 0.463457 0.334
R-HSA-201681 TCF dependent signaling in response to WNT 0.474709 0.324
R-HSA-168898 Toll-like Receptor Cascades 0.488019 0.312
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.509671 0.293
R-HSA-9730414 MITF-M-regulated melanocyte development 0.524471 0.280
R-HSA-162906 HIV Infection 0.545400 0.263
R-HSA-9705683 SARS-CoV-2-host interactions 0.546860 0.262
R-HSA-8939211 ESR-mediated signaling 0.559794 0.252
R-HSA-157118 Signaling by NOTCH 0.564024 0.249
R-HSA-212436 Generic Transcription Pathway 0.565253 0.248
R-HSA-5619115 Disorders of transmembrane transporters 0.573741 0.241
R-HSA-5688426 Deubiquitination 0.584585 0.233
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.601599 0.221
R-HSA-9658195 Leishmania infection 0.617995 0.209
R-HSA-9824443 Parasitic Infection Pathways 0.617995 0.209
R-HSA-382551 Transport of small molecules 0.622483 0.206
R-HSA-597592 Post-translational protein modification 0.625827 0.204
R-HSA-5673001 RAF/MAP kinase cascade 0.627735 0.202
R-HSA-1257604 PIP3 activates AKT signaling 0.634879 0.197
R-HSA-5684996 MAPK1/MAPK3 signaling 0.636057 0.197
R-HSA-195721 Signaling by WNT 0.638401 0.195
R-HSA-212165 Epigenetic regulation of gene expression 0.666481 0.176
R-HSA-5683057 MAPK family signaling cascades 0.691422 0.160
R-HSA-9006931 Signaling by Nuclear Receptors 0.707023 0.151
R-HSA-388396 GPCR downstream signalling 0.724118 0.140
R-HSA-425407 SLC-mediated transmembrane transport 0.738504 0.132
R-HSA-8978868 Fatty acid metabolism 0.746873 0.127
R-HSA-1266738 Developmental Biology 0.762801 0.118
R-HSA-9709957 Sensory Perception 0.771413 0.113
R-HSA-372790 Signaling by GPCR 0.774165 0.111
R-HSA-162582 Signal Transduction 0.774904 0.111
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.783524 0.106
R-HSA-168256 Immune System 0.804501 0.094
R-HSA-168249 Innate Immune System 0.812075 0.090
R-HSA-1430728 Metabolism 0.873466 0.059
R-HSA-556833 Metabolism of lipids 0.993383 0.003
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CK2A2CK2A2 0.775 0.541 1 0.761
CK2A1CK2A1 0.766 0.496 1 0.749
MOSMOS 0.758 0.277 1 0.728
BMPR1BBMPR1B 0.757 0.248 1 0.747
GRK7GRK7 0.752 0.321 1 0.601
GRK1GRK1 0.750 0.266 -2 0.814
ALK2ALK2 0.749 0.262 -2 0.804
FAM20CFAM20C 0.748 0.372 2 0.842
TGFBR1TGFBR1 0.746 0.191 -2 0.781
BMPR1ABMPR1A 0.746 0.228 1 0.763
CDC7CDC7 0.745 0.195 1 0.771
GRK6GRK6 0.745 0.290 1 0.659
CLK3CLK3 0.743 0.129 1 0.624
ACVR2BACVR2B 0.740 0.169 -2 0.791
CAMK2GCAMK2G 0.739 0.169 2 0.782
PRPKPRPK 0.737 0.032 -1 0.676
ACVR2AACVR2A 0.736 0.145 -2 0.782
CAMK2BCAMK2B 0.736 0.223 2 0.805
BMPR2BMPR2 0.733 -0.033 -2 0.856
COTCOT 0.733 0.055 2 0.719
ALK4ALK4 0.730 0.085 -2 0.806
CAMK2ACAMK2A 0.728 0.167 2 0.802
PLK3PLK3 0.728 0.163 2 0.729
CAMK1BCAMK1B 0.728 0.001 -3 0.748
JNK3JNK3 0.728 0.081 1 0.500
LATS1LATS1 0.728 0.135 -3 0.732
GRK5GRK5 0.727 0.090 -3 0.752
JNK2JNK2 0.727 0.080 1 0.474
SKMLCKSKMLCK 0.725 0.042 -2 0.859
PDHK4PDHK4 0.725 -0.057 1 0.592
DSTYKDSTYK 0.725 0.010 2 0.773
RAF1RAF1 0.724 -0.077 1 0.589
ATRATR 0.723 -0.033 1 0.509
ATMATM 0.723 0.050 1 0.471
PLK2PLK2 0.723 0.156 -3 0.802
DAPK2DAPK2 0.722 -0.015 -3 0.747
ERK5ERK5 0.722 -0.026 1 0.550
MARK4MARK4 0.721 0.038 4 0.726
IKKBIKKB 0.721 0.037 -2 0.734
PIM3PIM3 0.721 0.018 -3 0.714
CAMLCKCAMLCK 0.721 -0.016 -2 0.860
NLKNLK 0.720 -0.067 1 0.578
IKKAIKKA 0.720 0.113 -2 0.713
MEK1MEK1 0.720 -0.046 2 0.686
MTORMTOR 0.720 -0.046 1 0.545
CAMK2DCAMK2D 0.720 0.077 -3 0.710
GRK4GRK4 0.719 0.059 -2 0.831
JNK1JNK1 0.719 0.073 1 0.491
P38BP38B 0.718 0.053 1 0.478
CDKL1CDKL1 0.718 -0.042 -3 0.674
MAPKAPK2MAPKAPK2 0.718 0.098 -3 0.616
PASKPASK 0.717 0.066 -3 0.727
NIKNIK 0.717 -0.139 -3 0.768
CDK1CDK1 0.717 0.024 1 0.499
PDHK1PDHK1 0.716 -0.108 1 0.572
RSK2RSK2 0.716 0.042 -3 0.652
GRK2GRK2 0.716 0.040 -2 0.730
DLKDLK 0.715 -0.126 1 0.586
CLK2CLK2 0.715 0.092 -3 0.642
IKKEIKKE 0.714 -0.065 1 0.490
TSSK2TSSK2 0.714 0.020 -5 0.781
PLK1PLK1 0.714 0.030 -2 0.803
TBK1TBK1 0.714 -0.088 1 0.479
CDK8CDK8 0.714 0.020 1 0.505
DYRK4DYRK4 0.713 0.071 1 0.469
KISKIS 0.712 0.062 1 0.498
PRKD1PRKD1 0.712 0.031 -3 0.699
DYRK2DYRK2 0.712 0.025 1 0.492
ICKICK 0.712 -0.037 -3 0.713
DNAPKDNAPK 0.711 0.046 1 0.380
PIM1PIM1 0.711 0.006 -3 0.665
P38AP38A 0.711 0.015 1 0.492
HIPK4HIPK4 0.711 -0.015 1 0.516
HUNKHUNK 0.710 -0.089 2 0.642
NDR2NDR2 0.710 0.026 -3 0.712
NUAK2NUAK2 0.709 -0.065 -3 0.717
P38GP38G 0.709 0.030 1 0.438
P38DP38D 0.709 0.056 1 0.410
YSK4YSK4 0.708 -0.109 1 0.531
GRK3GRK3 0.708 0.068 -2 0.699
BRAFBRAF 0.708 -0.037 -4 0.685
P90RSKP90RSK 0.708 -0.006 -3 0.659
PRP4PRP4 0.707 -0.005 -3 0.710
RSK4RSK4 0.707 0.052 -3 0.617
GSK3AGSK3A 0.707 0.042 4 0.350
MARK2MARK2 0.707 0.033 4 0.671
CDK3CDK3 0.706 0.022 1 0.451
PKN3PKN3 0.706 -0.072 -3 0.689
SRPK1SRPK1 0.706 -0.018 -3 0.637
TGFBR2TGFBR2 0.706 -0.099 -2 0.804
MSK1MSK1 0.705 0.053 -3 0.627
MST4MST4 0.705 -0.084 2 0.671
AMPKA1AMPKA1 0.705 -0.050 -3 0.725
VRK2VRK2 0.705 -0.300 1 0.566
MLK1MLK1 0.705 -0.172 2 0.651
MARK3MARK3 0.705 0.032 4 0.684
MASTLMASTL 0.704 -0.206 -2 0.782
CDK19CDK19 0.704 0.012 1 0.475
TLK2TLK2 0.704 -0.072 1 0.477
ERK1ERK1 0.703 0.007 1 0.456
CLK4CLK4 0.703 0.009 -3 0.662
MAPKAPK3MAPKAPK3 0.703 -0.016 -3 0.654
GCN2GCN2 0.703 -0.177 2 0.649
CHK1CHK1 0.703 -0.004 -3 0.699
LATS2LATS2 0.703 0.010 -5 0.605
CDK5CDK5 0.703 -0.015 1 0.505
CHAK2CHAK2 0.702 -0.166 -1 0.596
BCKDKBCKDK 0.702 -0.083 -1 0.598
MSK2MSK2 0.702 0.007 -3 0.629
CDKL5CDKL5 0.701 -0.067 -3 0.662
QSKQSK 0.701 -0.006 4 0.709
MEKK3MEKK3 0.701 -0.133 1 0.523
PKRPKR 0.701 -0.194 1 0.492
DRAK1DRAK1 0.701 -0.042 1 0.542
AURAAURA 0.700 0.050 -2 0.698
MYLK4MYLK4 0.700 -0.007 -2 0.805
CDK2CDK2 0.700 -0.043 1 0.543
GAKGAK 0.700 -0.057 1 0.527
MARK1MARK1 0.700 0.006 4 0.688
SMG1SMG1 0.700 -0.055 1 0.446
TSSK1TSSK1 0.700 -0.042 -3 0.736
PKCDPKCD 0.699 -0.081 2 0.637
TTBK2TTBK2 0.699 -0.100 2 0.550
CDK13CDK13 0.699 -0.018 1 0.482
ERK2ERK2 0.699 -0.025 1 0.479
ANKRD3ANKRD3 0.699 -0.275 1 0.517
RIPK3RIPK3 0.698 -0.213 3 0.366
HIPK2HIPK2 0.698 0.022 1 0.437
SRPK3SRPK3 0.698 -0.047 -3 0.606
CDK17CDK17 0.698 -0.002 1 0.434
GSK3BGSK3B 0.698 -0.014 4 0.334
HIPK1HIPK1 0.698 -0.011 1 0.494
BRSK1BRSK1 0.697 -0.022 -3 0.673
MLK3MLK3 0.697 -0.117 2 0.609
TLK1TLK1 0.697 -0.098 -2 0.811
ULK2ULK2 0.697 -0.235 2 0.612
AMPKA2AMPKA2 0.697 -0.059 -3 0.692
TAO3TAO3 0.697 -0.110 1 0.529
WNK1WNK1 0.697 -0.161 -2 0.847
P70S6KBP70S6KB 0.697 -0.070 -3 0.674
NEK6NEK6 0.697 -0.167 -2 0.828
CDK7CDK7 0.696 -0.029 1 0.507
ALPHAK3ALPHAK3 0.696 0.101 -1 0.610
RSK3RSK3 0.695 -0.045 -3 0.650
PRKD2PRKD2 0.695 -0.032 -3 0.647
NEK7NEK7 0.695 -0.239 -3 0.748
GCKGCK 0.695 -0.092 1 0.525
CDK18CDK18 0.695 -0.003 1 0.449
MST2MST2 0.695 -0.088 1 0.539
PKN2PKN2 0.695 -0.127 -3 0.717
MEKK2MEKK2 0.695 -0.190 2 0.626
MEK5MEK5 0.694 -0.287 2 0.659
CAMK4CAMK4 0.694 -0.090 -3 0.700
NDR1NDR1 0.694 -0.101 -3 0.713
PAK1PAK1 0.694 -0.027 -2 0.814
CDK12CDK12 0.693 -0.018 1 0.463
TAK1TAK1 0.693 -0.096 1 0.540
PKACBPKACB 0.693 0.038 -2 0.730
DYRK1BDYRK1B 0.693 0.011 1 0.466
CLK1CLK1 0.693 -0.018 -3 0.643
SMMLCKSMMLCK 0.693 -0.059 -3 0.692
CK1DCK1D 0.692 0.006 -3 0.479
MLK2MLK2 0.692 -0.257 2 0.643
SRPK2SRPK2 0.692 -0.030 -3 0.559
MLK4MLK4 0.692 -0.144 2 0.588
DAPK3DAPK3 0.691 -0.008 -3 0.688
RIPK1RIPK1 0.691 -0.262 1 0.445
MST3MST3 0.691 -0.140 2 0.658
EEF2KEEF2K 0.691 -0.096 3 0.473
ZAKZAK 0.690 -0.200 1 0.521
DYRK1ADYRK1A 0.690 -0.024 1 0.516
CDK16CDK16 0.690 0.001 1 0.442
DAPK1DAPK1 0.690 0.006 -3 0.669
PKACGPKACG 0.690 -0.036 -2 0.778
QIKQIK 0.689 -0.121 -3 0.711
AURCAURC 0.689 0.009 -2 0.722
NIM1NIM1 0.689 -0.112 3 0.437
PERKPERK 0.689 -0.198 -2 0.824
CK1ECK1E 0.689 -0.010 -3 0.527
CDK14CDK14 0.689 -0.022 1 0.464
SIKSIK 0.688 -0.046 -3 0.649
NEK9NEK9 0.688 -0.289 2 0.627
PRKXPRKX 0.688 0.057 -3 0.573
CAMKK1CAMKK1 0.687 -0.162 -2 0.747
HIPK3HIPK3 0.687 -0.044 1 0.473
MEKK1MEKK1 0.687 -0.251 1 0.492
WNK3WNK3 0.687 -0.291 1 0.489
ULK1ULK1 0.687 -0.210 -3 0.723
CAMK1DCAMK1D 0.687 -0.016 -3 0.582
TAO2TAO2 0.687 -0.174 2 0.675
PRKD3PRKD3 0.687 -0.066 -3 0.638
CDK9CDK9 0.686 -0.043 1 0.479
PAK2PAK2 0.686 -0.070 -2 0.807
ERK7ERK7 0.686 -0.043 2 0.411
DCAMKL1DCAMKL1 0.686 -0.091 -3 0.677
DYRK3DYRK3 0.685 -0.011 1 0.483
TNIKTNIK 0.685 -0.128 3 0.472
SBKSBK 0.685 0.015 -3 0.465
MPSK1MPSK1 0.684 -0.109 1 0.426
HPK1HPK1 0.684 -0.116 1 0.509
PAK3PAK3 0.684 -0.092 -2 0.803
MAP3K15MAP3K15 0.684 -0.185 1 0.495
LKB1LKB1 0.684 -0.174 -3 0.727
SSTKSSTK 0.683 -0.053 4 0.672
PIM2PIM2 0.683 -0.071 -3 0.625
DCAMKL2DCAMKL2 0.683 -0.098 -3 0.705
AURBAURB 0.683 -0.018 -2 0.719
NEK2NEK2 0.683 -0.194 2 0.605
SGK3SGK3 0.682 -0.050 -3 0.636
PINK1PINK1 0.682 -0.210 1 0.498
MINKMINK 0.682 -0.163 1 0.489
CK1A2CK1A2 0.682 -0.021 -3 0.476
MNK1MNK1 0.682 -0.066 -2 0.812
NEK11NEK11 0.682 -0.247 1 0.497
PKCAPKCA 0.681 -0.103 2 0.575
MAKMAK 0.681 0.007 -2 0.750
BRSK2BRSK2 0.681 -0.100 -3 0.696
PKCGPKCG 0.681 -0.114 2 0.599
MST1MST1 0.681 -0.155 1 0.505
AKT2AKT2 0.681 -0.051 -3 0.576
TTBK1TTBK1 0.681 -0.102 2 0.501
CAMKK2CAMKK2 0.681 -0.175 -2 0.741
HRIHRI 0.681 -0.266 -2 0.829
PLK4PLK4 0.680 -0.135 2 0.501
NUAK1NUAK1 0.680 -0.111 -3 0.669
HGKHGK 0.680 -0.175 3 0.452
NEK8NEK8 0.679 -0.266 2 0.639
ASK1ASK1 0.679 -0.119 1 0.506
KHS1KHS1 0.679 -0.117 1 0.485
NEK5NEK5 0.679 -0.298 1 0.455
PDK1PDK1 0.679 -0.182 1 0.471
MNK2MNK2 0.678 -0.076 -2 0.803
PKACAPKACA 0.678 0.019 -2 0.680
PKG2PKG2 0.677 -0.034 -2 0.726
PKCBPKCB 0.677 -0.125 2 0.582
KHS2KHS2 0.677 -0.106 1 0.496
PKCHPKCH 0.676 -0.142 2 0.565
CAMK1GCAMK1G 0.676 -0.106 -3 0.635
MEK2MEK2 0.676 -0.211 2 0.620
LRRK2LRRK2 0.676 -0.252 2 0.669
CDK10CDK10 0.676 -0.032 1 0.447
BUB1BUB1 0.676 -0.023 -5 0.757
MEKK6MEKK6 0.675 -0.250 1 0.504
VRK1VRK1 0.675 -0.276 2 0.635
PAK6PAK6 0.674 -0.021 -2 0.740
CDK6CDK6 0.674 -0.048 1 0.440
MAPKAPK5MAPKAPK5 0.674 -0.123 -3 0.587
MELKMELK 0.673 -0.177 -3 0.679
CDK4CDK4 0.672 -0.045 1 0.456
CHAK1CHAK1 0.672 -0.301 2 0.577
IRE1IRE1 0.672 -0.288 1 0.415
IRE2IRE2 0.671 -0.242 2 0.572
WNK4WNK4 0.671 -0.253 -2 0.831
SNRKSNRK 0.671 -0.219 2 0.557
YANK3YANK3 0.670 -0.039 2 0.399
NEK4NEK4 0.670 -0.278 1 0.440
SLKSLK 0.669 -0.151 -2 0.711
OSR1OSR1 0.669 -0.161 2 0.604
NEK1NEK1 0.668 -0.268 1 0.439
CK1G1CK1G1 0.668 -0.052 -3 0.541
PKCZPKCZ 0.668 -0.194 2 0.593
MRCKAMRCKA 0.668 -0.060 -3 0.640
SGK1SGK1 0.667 -0.025 -3 0.501
RIPK2RIPK2 0.667 -0.234 1 0.472
DMPK1DMPK1 0.667 -0.037 -3 0.647
AKT1AKT1 0.667 -0.058 -3 0.590
ROCK2ROCK2 0.666 -0.074 -3 0.671
TTKTTK 0.666 -0.143 -2 0.827
CAMK1ACAMK1A 0.666 -0.054 -3 0.556
BIKEBIKE 0.666 -0.089 1 0.400
MOKMOK 0.665 -0.059 1 0.463
YSK1YSK1 0.665 -0.209 2 0.607
PBKPBK 0.664 -0.145 1 0.438
MRCKBMRCKB 0.664 -0.067 -3 0.619
PHKG1PHKG1 0.664 -0.211 -3 0.710
CHK2CHK2 0.663 -0.093 -3 0.536
LOKLOK 0.663 -0.216 -2 0.757
PDHK3_TYRPDHK3_TYR 0.662 0.286 4 0.731
IRAK1IRAK1 0.662 -0.301 -1 0.519
PKCTPKCT 0.661 -0.151 2 0.566
P70S6KP70S6K 0.661 -0.118 -3 0.581
PKCEPKCE 0.661 -0.107 2 0.576
IRAK4IRAK4 0.660 -0.321 1 0.411
PKCIPKCI 0.656 -0.164 2 0.565
MYO3AMYO3A 0.656 -0.193 1 0.445
STLK3STLK3 0.655 -0.184 1 0.496
MAP2K6_TYRMAP2K6_TYR 0.655 0.188 -1 0.682
PDHK4_TYRPDHK4_TYR 0.655 0.188 2 0.786
AAK1AAK1 0.655 -0.056 1 0.311
TAO1TAO1 0.654 -0.197 1 0.449
PHKG2PHKG2 0.653 -0.180 -3 0.684
PDHK1_TYRPDHK1_TYR 0.652 0.143 -1 0.684
EPHA4EPHA4 0.652 0.140 2 0.750
PAK5PAK5 0.652 -0.060 -2 0.699
HASPINHASPIN 0.652 -0.140 -1 0.484
TXKTXK 0.652 0.111 1 0.708
MYO3BMYO3B 0.651 -0.213 2 0.632
AKT3AKT3 0.651 -0.057 -3 0.520
MAP2K4_TYRMAP2K4_TYR 0.651 0.131 -1 0.702
CRIKCRIK 0.650 -0.084 -3 0.577
STK33STK33 0.650 -0.218 2 0.527
BMPR2_TYRBMPR2_TYR 0.649 0.089 -1 0.700
ROCK1ROCK1 0.649 -0.092 -3 0.638
PKN1PKN1 0.649 -0.133 -3 0.604
SRMSSRMS 0.646 0.109 1 0.685
CK1ACK1A 0.646 -0.024 -3 0.409
PAK4PAK4 0.646 -0.055 -2 0.704
EPHA6EPHA6 0.645 0.055 -1 0.674
MAP2K7_TYRMAP2K7_TYR 0.644 0.030 2 0.737
TESK1_TYRTESK1_TYR 0.643 -0.054 3 0.522
NEK3NEK3 0.643 -0.314 1 0.430
SYKSYK 0.642 0.133 -1 0.633
FERFER 0.642 0.049 1 0.675
FYNFYN 0.641 0.071 -1 0.669
CK1G3CK1G3 0.641 -0.032 -3 0.368
EPHB2EPHB2 0.640 0.073 -1 0.641
YANK2YANK2 0.640 -0.067 2 0.419
PTK2PTK2 0.639 0.095 -1 0.670
EPHB4EPHB4 0.639 0.020 -1 0.660
PKMYT1_TYRPKMYT1_TYR 0.637 -0.097 3 0.486
EPHA5EPHA5 0.637 0.098 2 0.753
EPHB1EPHB1 0.635 0.015 1 0.665
YES1YES1 0.634 -0.020 -1 0.674
INSRRINSRR 0.634 -0.027 3 0.372
EPHB3EPHB3 0.634 0.017 -1 0.633
HCKHCK 0.633 -0.042 -1 0.662
EPHA7EPHA7 0.633 0.034 2 0.723
EGFREGFR 0.632 0.040 1 0.512
BMXBMX 0.632 0.001 -1 0.596
PINK1_TYRPINK1_TYR 0.632 -0.167 1 0.575
PKG1PKG1 0.631 -0.075 -2 0.659
EPHA3EPHA3 0.631 0.002 2 0.717
MERTKMERTK 0.631 -0.020 3 0.409
CK1G2CK1G2 0.630 -0.038 -3 0.458
LCKLCK 0.630 -0.038 -1 0.662
PTK2BPTK2B 0.630 -0.000 -1 0.598
ITKITK 0.629 -0.044 -1 0.623
BLKBLK 0.629 -0.009 -1 0.656
FGFR2FGFR2 0.628 -0.071 3 0.412
EPHA8EPHA8 0.628 0.009 -1 0.618
TECTEC 0.627 -0.035 -1 0.596
FGRFGR 0.627 -0.101 1 0.558
CSF1RCSF1R 0.627 -0.137 3 0.400
LYNLYN 0.626 -0.030 3 0.355
EPHA2EPHA2 0.626 0.034 -1 0.622
RETRET 0.625 -0.170 1 0.511
TYRO3TYRO3 0.625 -0.168 3 0.400
FGFR3FGFR3 0.625 -0.053 3 0.393
MST1RMST1R 0.625 -0.212 3 0.416
LIMK2_TYRLIMK2_TYR 0.625 -0.163 -3 0.770
SRCSRC 0.624 -0.021 -1 0.659
ABL2ABL2 0.624 -0.096 -1 0.616
KITKIT 0.624 -0.115 3 0.401
JAK3JAK3 0.624 -0.135 1 0.528
JAK2JAK2 0.623 -0.196 1 0.514
ERBB4ERBB4 0.623 0.014 1 0.564
TYK2TYK2 0.622 -0.223 1 0.506
NTRK1NTRK1 0.622 -0.089 -1 0.643
FGFR4FGFR4 0.622 -0.012 -1 0.606
DDR1DDR1 0.622 -0.136 4 0.633
ERBB2ERBB2 0.622 -0.087 1 0.553
FRKFRK 0.621 -0.065 -1 0.646
TEKTEK 0.621 -0.118 3 0.351
ABL1ABL1 0.621 -0.120 -1 0.613
LIMK1_TYRLIMK1_TYR 0.621 -0.236 2 0.688
ROS1ROS1 0.620 -0.209 3 0.368
BTKBTK 0.620 -0.111 -1 0.600
FGFR1FGFR1 0.620 -0.133 3 0.385
FLT1FLT1 0.619 -0.078 -1 0.651
LTKLTK 0.617 -0.107 3 0.371
FLT3FLT3 0.617 -0.173 3 0.393
CSKCSK 0.617 -0.057 2 0.715
EPHA1EPHA1 0.616 -0.099 3 0.367
NTRK3NTRK3 0.616 -0.090 -1 0.605
METMET 0.616 -0.124 3 0.393
INSRINSR 0.615 -0.108 3 0.357
AXLAXL 0.615 -0.142 3 0.383
ALKALK 0.615 -0.137 3 0.341
PTK6PTK6 0.613 -0.126 -1 0.562
IGF1RIGF1R 0.613 -0.058 3 0.323
NEK10_TYRNEK10_TYR 0.612 -0.139 1 0.449
KDRKDR 0.612 -0.179 3 0.370
JAK1JAK1 0.611 -0.168 1 0.470
TNK2TNK2 0.610 -0.180 3 0.360
FLT4FLT4 0.609 -0.162 3 0.387
PDGFRBPDGFRB 0.609 -0.238 3 0.396
NTRK2NTRK2 0.608 -0.180 3 0.370
FESFES 0.608 -0.050 -1 0.575
MATKMATK 0.608 -0.102 -1 0.537
ZAP70ZAP70 0.605 -0.012 -1 0.571
WEE1_TYRWEE1_TYR 0.603 -0.166 -1 0.579
PDGFRAPDGFRA 0.602 -0.285 3 0.393
DDR2DDR2 0.600 -0.094 3 0.346
TNNI3K_TYRTNNI3K_TYR 0.598 -0.194 1 0.490
TNK1TNK1 0.597 -0.241 3 0.402
MUSKMUSK 0.589 -0.178 1 0.465