Motif 1184 (n=62)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP55 | UQCRHL | T11 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
| A0A096LP55 | UQCRHL | S13 | ochoa | Cytochrome b-c1 complex subunit 6-like, mitochondrial | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}. |
| A0A1W2PR48 | TLE7 | S9 | ochoa | Transducin-like enhancer protein 7 | None |
| B5ME19 | EIF3CL | S9 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| J3KQ70 | INO80B-WBP1 | T10 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
| O60841 | EIF5B | S9 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O95562 | SFT2D2 | S9 | ochoa | Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) | May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}. |
| P02730 | SLC4A1 | Y8 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04637 | TP53 | S9 | ochoa|psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P06454 | PTMA | S10 | ochoa | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. |
| P06730 | EIF4E | T9 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07919 | UQCRH | T11 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P07919 | UQCRH | S13 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P0CG47 | UBB | T9 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T9 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P10073 | ZSCAN22 | S9 | ochoa | Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) | May be involved in transcriptional regulation. |
| P12956 | XRCC6 | T10 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13807 | GYS1 | S10 | ochoa|psp | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P17028 | ZNF24 | S10 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17029 | ZKSCAN1 | T10 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P26639 | TARS1 | S10 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P28289 | TMOD1 | Y10 | ochoa | Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}. |
| P28347 | TEAD1 | S9 | ochoa | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| P40855 | PEX19 | S9 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| P45973 | CBX5 | T8 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P49810 | PSEN2 | S9 | psp | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
| P51798 | CLCN7 | S9 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P54619 | PRKAG1 | S9 | ochoa | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:21680840, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:21680840, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:21680840, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:21680840, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:21680840, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:21680840, PubMed:24563466). {ECO:0000269|PubMed:21680840, ECO:0000269|PubMed:24563466}. |
| P55209 | NAP1L1 | S10 | ochoa | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:26841755, ECO:0000269|PubMed:28369616}.; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. {ECO:0000269|PubMed:23691099}.; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. {ECO:0000269|PubMed:27599637}. |
| P62316 | SNRPD2 | S9 | ochoa | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}. |
| P62979 | RPS27A | T9 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T9 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P63165 | SUMO1 | S9 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| Q14974 | KPNB1 | T10 | ochoa | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
| Q15311 | RALBP1 | T9 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15776 | ZKSCAN8 | S9 | ochoa | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) | May be involved in transcriptional regulation. |
| Q16667 | CDKN3 | T9 | ochoa | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}. |
| Q16667 | CDKN3 | S10 | ochoa | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}. |
| Q58FF6 | HSP90AB4P | Y9 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q6T311 | ARL9 | S9 | ochoa | ADP-ribosylation factor-like protein 9 | None |
| Q8IU68 | TMC8 | S9 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q8IYE0 | CCDC146 | T8 | ochoa | Coiled-coil domain-containing protein 146 | Essential for sperm flagellum biogenesis and male fertility. {ECO:0000250|UniProtKB:E9Q9F7}. |
| Q8N3U4 | STAG2 | T9 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q969F1 | GTF3C6 | S9 | ochoa | General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. {ECO:0000269|PubMed:17409385}. |
| Q96AY2 | EME1 | S9 | ochoa | Structure-specific endonuclease subunit EME1 (Crossover junction endonuclease EME1) (Essential meiotic structure-specific endonuclease 1) (MMS4 homolog) (hMMS4) | Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME1 which is involved in the maintenance of genome stability. In the complex, EME1 is required for DNA cleavage, participating in DNA recognition and bending (PubMed:12686547, PubMed:12721304, PubMed:14617801, PubMed:17289582, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). MUS81-EME1 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24733841, PubMed:35290797). Active during prometaphase, MUS81-EME1 resolves mitotic recombination intermediates, including Holliday junctions, which form during homologous recombination (PubMed:14617801, PubMed:24813886). {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96ET8 | TVP23C | T10 | ochoa | Golgi apparatus membrane protein TVP23 homolog C | None |
| Q99613 | EIF3C | S9 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q9BPY8 | HOPX | T10 | ochoa | Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1) | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}. |
| Q9C086 | INO80B | T10 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
| Q9NWV8 | BABAM1 | S7 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NWV8 | BABAM1 | S8 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NWV8 | BABAM1 | T10 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NYZ1 | TVP23B | T10 | ochoa | Golgi apparatus membrane protein TVP23 homolog B | None |
| Q9NZT2 | OGFR | T9 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P1V8 | SAMD15 | S10 | ochoa | Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) | None |
| Q9P215 | POGK | S11 | ochoa | Pogo transposable element with KRAB domain | None |
| Q9P273 | TENM3 | Y9 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9UHR5 | SAP30BP | S9 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UQR0 | SCML2 | S9 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y2J2 | EPB41L3 | S9 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y4P1 | ATG4B | T10 | ochoa | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| P61024 | CKS1B | S9 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.011526e-09 | 8.995 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.395217e-09 | 8.855 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 2.083812e-08 | 7.681 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.162133e-08 | 7.935 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.956311e-08 | 7.709 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.739882e-09 | 8.011 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.093546e-08 | 7.679 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.211203e-08 | 7.493 |
| R-HSA-3229121 | Glycogen storage diseases | 3.131815e-08 | 7.504 |
| R-HSA-9694493 | Maturation of protein E | 3.544492e-08 | 7.450 |
| R-HSA-9683683 | Maturation of protein E | 3.544492e-08 | 7.450 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.899593e-08 | 7.409 |
| R-HSA-3322077 | Glycogen synthesis | 5.881325e-08 | 7.231 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 7.354564e-08 | 7.133 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 7.134104e-08 | 7.147 |
| R-HSA-8948747 | Regulation of PTEN localization | 8.602995e-08 | 7.065 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.027207e-07 | 6.988 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.255881e-07 | 6.901 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.255881e-07 | 6.901 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.255881e-07 | 6.901 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.255881e-07 | 6.901 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.773498e-07 | 6.751 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.978832e-07 | 6.704 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.978832e-07 | 6.704 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.978832e-07 | 6.704 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.435607e-07 | 6.613 |
| R-HSA-5689877 | Josephin domain DUBs | 2.435607e-07 | 6.613 |
| R-HSA-9664873 | Pexophagy | 2.435607e-07 | 6.613 |
| R-HSA-73894 | DNA Repair | 2.507671e-07 | 6.601 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 3.266437e-07 | 6.486 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 3.266437e-07 | 6.486 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 4.291958e-07 | 6.367 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 5.539860e-07 | 6.257 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 5.539860e-07 | 6.257 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 5.539860e-07 | 6.257 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 4.291958e-07 | 6.367 |
| R-HSA-209560 | NF-kB is activated and signals survival | 4.291958e-07 | 6.367 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 5.539860e-07 | 6.257 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 5.539860e-07 | 6.257 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 5.539860e-07 | 6.257 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.524590e-07 | 6.258 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 5.539860e-07 | 6.257 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.889561e-07 | 6.410 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.895809e-07 | 6.229 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 7.039521e-07 | 6.152 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 6.650602e-07 | 6.177 |
| R-HSA-1980145 | Signaling by NOTCH2 | 6.650602e-07 | 6.177 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.770414e-07 | 6.169 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 8.821979e-07 | 6.054 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 8.821979e-07 | 6.054 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.388429e-07 | 6.076 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 8.821979e-07 | 6.054 |
| R-HSA-2559585 | Oncogene Induced Senescence | 7.479739e-07 | 6.126 |
| R-HSA-5693538 | Homology Directed Repair | 9.206722e-07 | 6.036 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 9.382101e-07 | 6.028 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.091991e-06 | 5.962 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.091991e-06 | 5.962 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.091991e-06 | 5.962 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.091991e-06 | 5.962 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.091991e-06 | 5.962 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 9.905324e-07 | 6.004 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.091991e-06 | 5.962 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.091991e-06 | 5.962 |
| R-HSA-69541 | Stabilization of p53 | 1.164723e-06 | 5.934 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.293068e-06 | 5.888 |
| R-HSA-8982491 | Glycogen metabolism | 1.293068e-06 | 5.888 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.336760e-06 | 5.874 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.336760e-06 | 5.874 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.336760e-06 | 5.874 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.620092e-06 | 5.790 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.620092e-06 | 5.790 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.620092e-06 | 5.790 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.620092e-06 | 5.790 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.583105e-06 | 5.800 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.787638e-06 | 5.748 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.922107e-06 | 5.716 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.945728e-06 | 5.711 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.111749e-06 | 5.675 |
| R-HSA-69236 | G1 Phase | 2.111749e-06 | 5.675 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.111749e-06 | 5.675 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.147560e-06 | 5.668 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.739647e-06 | 5.562 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.739647e-06 | 5.562 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.317564e-06 | 5.635 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.770356e-06 | 5.557 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.739647e-06 | 5.562 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.739647e-06 | 5.562 |
| R-HSA-1632852 | Macroautophagy | 2.994373e-06 | 5.524 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.751471e-06 | 5.426 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.292262e-06 | 5.483 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.292262e-06 | 5.483 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.751471e-06 | 5.426 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.216170e-06 | 5.493 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.751471e-06 | 5.426 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.751471e-06 | 5.426 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.751471e-06 | 5.426 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.751471e-06 | 5.426 |
| R-HSA-68882 | Mitotic Anaphase | 4.020864e-06 | 5.396 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.146550e-06 | 5.382 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.216709e-06 | 5.375 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.216709e-06 | 5.375 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.350035e-06 | 5.362 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.350035e-06 | 5.362 |
| R-HSA-175474 | Assembly Of The HIV Virion | 4.350035e-06 | 5.362 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 4.350035e-06 | 5.362 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 4.350035e-06 | 5.362 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.456935e-06 | 5.351 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 5.016483e-06 | 5.300 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.333568e-06 | 5.273 |
| R-HSA-9612973 | Autophagy | 5.602641e-06 | 5.252 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.087054e-06 | 5.092 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.010767e-06 | 5.154 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.489309e-06 | 5.188 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 6.572213e-06 | 5.182 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.697627e-06 | 5.114 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.697627e-06 | 5.114 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.697627e-06 | 5.114 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.697627e-06 | 5.114 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.697627e-06 | 5.114 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.355743e-06 | 5.133 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 8.458362e-06 | 5.073 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.845079e-06 | 5.053 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 9.466794e-06 | 5.024 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 9.538325e-06 | 5.021 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 9.538325e-06 | 5.021 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 9.538325e-06 | 5.021 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.071673e-05 | 4.970 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.071673e-05 | 4.970 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.129047e-05 | 4.947 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 1.199910e-05 | 4.921 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.199910e-05 | 4.921 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.199910e-05 | 4.921 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.199910e-05 | 4.921 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.199910e-05 | 4.921 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.268253e-05 | 4.897 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.268253e-05 | 4.897 |
| R-HSA-5218859 | Regulated Necrosis | 1.310624e-05 | 4.883 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.339112e-05 | 4.873 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.483486e-05 | 4.829 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.483486e-05 | 4.829 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.489856e-05 | 4.827 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.489856e-05 | 4.827 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.489856e-05 | 4.827 |
| R-HSA-182971 | EGFR downregulation | 1.489856e-05 | 4.827 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 1.489856e-05 | 4.827 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.652731e-05 | 4.782 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.673634e-05 | 4.776 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.775562e-05 | 4.751 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.775562e-05 | 4.751 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.828339e-05 | 4.738 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.828339e-05 | 4.738 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.882262e-05 | 4.725 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.882262e-05 | 4.725 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.017293e-05 | 4.695 |
| R-HSA-69481 | G2/M Checkpoints | 2.077258e-05 | 4.683 |
| R-HSA-5689603 | UCH proteinases | 2.110610e-05 | 4.676 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.110610e-05 | 4.676 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.220216e-05 | 4.654 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.220216e-05 | 4.654 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.220216e-05 | 4.654 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.220216e-05 | 4.654 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.220216e-05 | 4.654 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.220216e-05 | 4.654 |
| R-HSA-5205647 | Mitophagy | 2.220216e-05 | 4.654 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.232577e-05 | 4.651 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.437742e-05 | 4.613 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.437742e-05 | 4.613 |
| R-HSA-4641258 | Degradation of DVL | 2.919197e-05 | 4.535 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.670518e-05 | 4.573 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.670518e-05 | 4.573 |
| R-HSA-4641257 | Degradation of AXIN | 2.919197e-05 | 4.535 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.919197e-05 | 4.535 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.466940e-05 | 4.460 |
| R-HSA-169911 | Regulation of Apoptosis | 2.437742e-05 | 4.613 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.184446e-05 | 4.497 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.776284e-05 | 4.557 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.919197e-05 | 4.535 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.919197e-05 | 4.535 |
| R-HSA-9648002 | RAS processing | 3.466940e-05 | 4.460 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.466940e-05 | 4.460 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.670518e-05 | 4.573 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.594652e-05 | 4.444 |
| R-HSA-9646399 | Aggrephagy | 3.767366e-05 | 4.424 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.767366e-05 | 4.424 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.767366e-05 | 4.424 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.086418e-05 | 4.389 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.086418e-05 | 4.389 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.086418e-05 | 4.389 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.086418e-05 | 4.389 |
| R-HSA-9607240 | FLT3 Signaling | 4.086418e-05 | 4.389 |
| R-HSA-9663891 | Selective autophagy | 4.168492e-05 | 4.380 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.424800e-05 | 4.354 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.424800e-05 | 4.354 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.424800e-05 | 4.354 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.424800e-05 | 4.354 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.424800e-05 | 4.354 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.783227e-05 | 4.320 |
| R-HSA-69242 | S Phase | 4.929999e-05 | 4.307 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.162421e-05 | 4.287 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.162421e-05 | 4.287 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.162421e-05 | 4.287 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.279915e-05 | 4.277 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.527306e-05 | 4.257 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.986044e-05 | 4.223 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.986044e-05 | 4.223 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.986044e-05 | 4.223 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.986044e-05 | 4.223 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.986044e-05 | 4.223 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.986044e-05 | 4.223 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.048903e-05 | 4.218 |
| R-HSA-72766 | Translation | 6.280640e-05 | 4.202 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.431962e-05 | 4.192 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.431962e-05 | 4.192 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.431962e-05 | 4.192 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.431962e-05 | 4.192 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.901624e-05 | 4.161 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.205576e-05 | 4.142 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.205576e-05 | 4.142 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.205576e-05 | 4.142 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.519714e-05 | 4.124 |
| R-HSA-109581 | Apoptosis | 7.681185e-05 | 4.115 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.844306e-05 | 4.105 |
| R-HSA-73893 | DNA Damage Bypass | 7.915247e-05 | 4.102 |
| R-HSA-9766229 | Degradation of CDH1 | 7.915247e-05 | 4.102 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 7.915247e-05 | 4.102 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 7.915247e-05 | 4.102 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.158167e-05 | 4.088 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.179589e-05 | 4.087 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 8.460761e-05 | 4.073 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.525805e-05 | 4.069 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.005786e-05 | 4.045 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 9.033124e-05 | 4.044 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 9.033124e-05 | 4.044 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 9.033124e-05 | 4.044 |
| R-HSA-6804754 | Regulation of TP53 Expression | 1.192955e-04 | 3.923 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 9.633133e-05 | 4.016 |
| R-HSA-72649 | Translation initiation complex formation | 1.091930e-04 | 3.962 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.232576e-04 | 3.909 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.232576e-04 | 3.909 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.385913e-04 | 3.858 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.385913e-04 | 3.858 |
| R-HSA-5688426 | Deubiquitination | 1.014657e-04 | 3.994 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9.633133e-05 | 4.016 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.026159e-04 | 3.989 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.026159e-04 | 3.989 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.127622e-04 | 3.948 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.160708e-04 | 3.935 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.232576e-04 | 3.909 |
| R-HSA-68949 | Orc1 removal from chromatin | 9.633133e-05 | 4.016 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.091930e-04 | 3.962 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.026159e-04 | 3.989 |
| R-HSA-9033241 | Peroxisomal protein import | 1.467549e-04 | 3.833 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.084770e-04 | 3.965 |
| R-HSA-75893 | TNF signaling | 1.232576e-04 | 3.909 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.217478e-04 | 3.915 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.217478e-04 | 3.915 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.002491e-04 | 3.999 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.127622e-04 | 3.948 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.641182e-04 | 3.785 |
| R-HSA-68886 | M Phase | 1.747070e-04 | 3.758 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.060561e-04 | 3.974 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.171889e-04 | 3.931 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.814050e-04 | 3.741 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.814050e-04 | 3.741 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.362446e-04 | 3.866 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.307617e-04 | 3.884 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.520291e-04 | 3.818 |
| R-HSA-1640170 | Cell Cycle | 1.133967e-04 | 3.945 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.232576e-04 | 3.909 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.575898e-04 | 3.802 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.171889e-04 | 3.931 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.552610e-04 | 3.809 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.733349e-04 | 3.761 |
| R-HSA-450294 | MAP kinase activation | 1.641182e-04 | 3.785 |
| R-HSA-177929 | Signaling by EGFR | 1.232576e-04 | 3.909 |
| R-HSA-913531 | Interferon Signaling | 1.776625e-04 | 3.750 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.232576e-04 | 3.909 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.127622e-04 | 3.948 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.084651e-04 | 3.965 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.084651e-04 | 3.965 |
| R-HSA-8848021 | Signaling by PTK6 | 1.829199e-04 | 3.738 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.829199e-04 | 3.738 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.928818e-04 | 3.715 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.942969e-04 | 3.712 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.009993e-04 | 3.697 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.009993e-04 | 3.697 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.032294e-04 | 3.692 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.149323e-04 | 3.668 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.214175e-04 | 3.655 |
| R-HSA-69206 | G1/S Transition | 2.295900e-04 | 3.639 |
| R-HSA-5357801 | Programmed Cell Death | 2.557183e-04 | 3.592 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.610625e-04 | 3.583 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.610625e-04 | 3.583 |
| R-HSA-448424 | Interleukin-17 signaling | 2.610625e-04 | 3.583 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.739106e-04 | 3.562 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.739106e-04 | 3.562 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.739106e-04 | 3.562 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.872070e-04 | 3.542 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.009608e-04 | 3.521 |
| R-HSA-8852135 | Protein ubiquitination | 3.298768e-04 | 3.482 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.298768e-04 | 3.482 |
| R-HSA-917937 | Iron uptake and transport | 3.298768e-04 | 3.482 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.546243e-04 | 3.450 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.651972e-04 | 3.437 |
| R-HSA-6807070 | PTEN Regulation | 3.760072e-04 | 3.425 |
| R-HSA-5619084 | ABC transporter disorders | 3.769107e-04 | 3.424 |
| R-HSA-4086400 | PCP/CE pathway | 3.769107e-04 | 3.424 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.108147e-04 | 3.386 |
| R-HSA-6806834 | Signaling by MET | 4.108147e-04 | 3.386 |
| R-HSA-162906 | HIV Infection | 4.187568e-04 | 3.378 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.277377e-04 | 3.369 |
| R-HSA-977225 | Amyloid fiber formation | 4.285592e-04 | 3.368 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.468445e-04 | 3.350 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.656801e-04 | 3.332 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.714418e-04 | 3.327 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.850753e-04 | 3.314 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.850753e-04 | 3.314 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.979191e-04 | 3.303 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.050397e-04 | 3.297 |
| R-HSA-157118 | Signaling by NOTCH | 5.477186e-04 | 3.261 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.542206e-04 | 3.256 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.542206e-04 | 3.256 |
| R-HSA-70268 | Pyruvate metabolism | 5.684431e-04 | 3.245 |
| R-HSA-9609507 | Protein localization | 5.690150e-04 | 3.245 |
| R-HSA-69306 | DNA Replication | 5.690150e-04 | 3.245 |
| R-HSA-73887 | Death Receptor Signaling | 5.841044e-04 | 3.234 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.969200e-04 | 3.224 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.137324e-04 | 3.212 |
| R-HSA-162587 | HIV Life Cycle | 6.311815e-04 | 3.200 |
| R-HSA-202424 | Downstream TCR signaling | 6.373119e-04 | 3.196 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.810521e-04 | 3.167 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.119051e-04 | 3.148 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.467556e-04 | 3.127 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.924824e-04 | 3.101 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.207165e-04 | 3.086 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.207165e-04 | 3.086 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.496541e-04 | 3.071 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.793049e-04 | 3.056 |
| R-HSA-190236 | Signaling by FGFR | 9.096786e-04 | 3.041 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.538270e-04 | 3.021 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.726337e-04 | 3.012 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.107646e-03 | 2.956 |
| R-HSA-2559583 | Cellular Senescence | 1.117313e-03 | 2.952 |
| R-HSA-9833110 | RSV-host interactions | 1.143351e-03 | 2.942 |
| R-HSA-69239 | Synthesis of DNA | 1.255310e-03 | 2.901 |
| R-HSA-69275 | G2/M Transition | 1.273271e-03 | 2.895 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.288493e-03 | 2.890 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.294276e-03 | 2.888 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.328671e-03 | 2.877 |
| R-HSA-983712 | Ion channel transport | 1.357031e-03 | 2.867 |
| R-HSA-202403 | TCR signaling | 1.374735e-03 | 2.862 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.415091e-03 | 2.849 |
| R-HSA-9679506 | SARS-CoV Infections | 1.794355e-03 | 2.746 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.802799e-03 | 2.744 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.880708e-03 | 2.726 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.907419e-03 | 2.720 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.984862e-03 | 2.702 |
| R-HSA-212436 | Generic Transcription Pathway | 2.650872e-03 | 2.577 |
| R-HSA-9909396 | Circadian clock | 2.761061e-03 | 2.559 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.875113e-03 | 2.541 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.893227e-03 | 2.539 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.108173e-03 | 2.507 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.255001e-03 | 2.487 |
| R-HSA-74160 | Gene expression (Transcription) | 3.515732e-03 | 2.454 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.642658e-03 | 2.439 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.642658e-03 | 2.439 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.723790e-03 | 2.429 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.806142e-03 | 2.420 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 3.904792e-03 | 2.408 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 3.904792e-03 | 2.408 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.968961e-03 | 2.401 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.417513e-03 | 2.355 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.092058e-03 | 2.293 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.777537e-03 | 2.238 |
| R-HSA-9865881 | Complex III assembly | 6.285820e-03 | 2.202 |
| R-HSA-156902 | Peptide chain elongation | 6.631195e-03 | 2.178 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.641975e-03 | 2.178 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.886223e-03 | 2.162 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.886223e-03 | 2.162 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 7.116138e-03 | 2.148 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.205887e-03 | 2.142 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.403816e-03 | 2.131 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.604947e-03 | 2.119 |
| R-HSA-168255 | Influenza Infection | 7.654549e-03 | 2.116 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.868568e-03 | 2.104 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.197004e-03 | 2.086 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.441737e-03 | 2.074 |
| R-HSA-9675108 | Nervous system development | 9.122948e-03 | 2.040 |
| R-HSA-2408557 | Selenocysteine synthesis | 9.794940e-03 | 2.009 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.013297e-02 | 1.994 |
| R-HSA-192823 | Viral mRNA Translation | 1.027247e-02 | 1.988 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.038653e-02 | 1.984 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.051624e-02 | 1.978 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.089875e-02 | 1.963 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.128871e-02 | 1.947 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.142193e-02 | 1.942 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.152487e-02 | 1.938 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 1.166941e-02 | 1.933 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.286175e-02 | 1.891 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.286175e-02 | 1.891 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.372657e-02 | 1.862 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.419937e-02 | 1.848 |
| R-HSA-418990 | Adherens junctions interactions | 1.424167e-02 | 1.846 |
| R-HSA-8951664 | Neddylation | 1.484495e-02 | 1.828 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.538405e-02 | 1.813 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 1.552936e-02 | 1.809 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 1.552936e-02 | 1.809 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.588605e-02 | 1.799 |
| R-HSA-165159 | MTOR signalling | 1.660979e-02 | 1.780 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.832057e-02 | 1.737 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 1.937447e-02 | 1.713 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.052653e-02 | 1.688 |
| R-HSA-421270 | Cell-cell junction organization | 2.177831e-02 | 1.662 |
| R-HSA-9824439 | Bacterial Infection Pathways | 2.241439e-02 | 1.649 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 2.320479e-02 | 1.634 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 2.320479e-02 | 1.634 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 2.320479e-02 | 1.634 |
| R-HSA-422475 | Axon guidance | 2.321930e-02 | 1.634 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.614708e-02 | 1.583 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.646033e-02 | 1.577 |
| R-HSA-446728 | Cell junction organization | 2.947702e-02 | 1.531 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.055041e-02 | 1.515 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.073882e-02 | 1.512 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 3.082132e-02 | 1.511 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 3.082132e-02 | 1.511 |
| R-HSA-5668914 | Diseases of metabolism | 3.093842e-02 | 1.510 |
| R-HSA-9711097 | Cellular response to starvation | 3.190594e-02 | 1.496 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.302328e-02 | 1.481 |
| R-HSA-9824446 | Viral Infection Pathways | 3.402160e-02 | 1.468 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 3.460764e-02 | 1.461 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.471064e-02 | 1.460 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.540529e-02 | 1.451 |
| R-HSA-195721 | Signaling by WNT | 3.610383e-02 | 1.442 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.813969e-02 | 1.419 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 3.837940e-02 | 1.416 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 3.837940e-02 | 1.416 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.859214e-02 | 1.414 |
| R-HSA-449147 | Signaling by Interleukins | 4.042086e-02 | 1.393 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.126633e-02 | 1.384 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.213666e-02 | 1.375 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 4.213666e-02 | 1.375 |
| R-HSA-1500931 | Cell-Cell communication | 4.275157e-02 | 1.369 |
| R-HSA-392499 | Metabolism of proteins | 4.540164e-02 | 1.343 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 4.587947e-02 | 1.338 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 4.587947e-02 | 1.338 |
| R-HSA-9613354 | Lipophagy | 4.587947e-02 | 1.338 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.682833e-02 | 1.329 |
| R-HSA-9833482 | PKR-mediated signaling | 4.682833e-02 | 1.329 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.772181e-02 | 1.321 |
| R-HSA-8953854 | Metabolism of RNA | 4.931575e-02 | 1.307 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 4.960789e-02 | 1.304 |
| R-HSA-164843 | 2-LTR circle formation | 4.960789e-02 | 1.304 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 4.960789e-02 | 1.304 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 4.960789e-02 | 1.304 |
| R-HSA-425381 | Bicarbonate transporters | 5.332196e-02 | 1.273 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.572449e-02 | 1.254 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 5.702176e-02 | 1.244 |
| R-HSA-162592 | Integration of provirus | 5.702176e-02 | 1.244 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 6.070732e-02 | 1.217 |
| R-HSA-877312 | Regulation of IFNG signaling | 6.070732e-02 | 1.217 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 6.070732e-02 | 1.217 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 6.437870e-02 | 1.191 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.437870e-02 | 1.191 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 6.437870e-02 | 1.191 |
| R-HSA-9683610 | Maturation of nucleoprotein | 6.437870e-02 | 1.191 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 6.803596e-02 | 1.167 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 6.803596e-02 | 1.167 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 7.167915e-02 | 1.145 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.370201e-02 | 1.133 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 7.530832e-02 | 1.123 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 7.530832e-02 | 1.123 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 7.530832e-02 | 1.123 |
| R-HSA-72312 | rRNA processing | 7.626728e-02 | 1.118 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 7.892354e-02 | 1.103 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 8.968591e-02 | 1.047 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 8.968591e-02 | 1.047 |
| R-HSA-9694631 | Maturation of nucleoprotein | 8.968591e-02 | 1.047 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 8.968591e-02 | 1.047 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.983069e-02 | 1.047 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.547891e-02 | 1.020 |
| R-HSA-382551 | Transport of small molecules | 9.578218e-02 | 1.019 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 9.679198e-02 | 1.014 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 9.679198e-02 | 1.014 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.823840e-02 | 1.008 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.003245e-01 | 0.999 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.003245e-01 | 0.999 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.006807e-01 | 0.997 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.021514e-01 | 0.991 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.038434e-01 | 0.984 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.038434e-01 | 0.984 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.038434e-01 | 0.984 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.038434e-01 | 0.984 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 1.073488e-01 | 0.969 |
| R-HSA-2262752 | Cellular responses to stress | 1.105210e-01 | 0.957 |
| R-HSA-429947 | Deadenylation of mRNA | 1.108407e-01 | 0.955 |
| R-HSA-597592 | Post-translational protein modification | 1.169644e-01 | 0.932 |
| R-HSA-199991 | Membrane Trafficking | 1.208007e-01 | 0.918 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.212360e-01 | 0.916 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.212360e-01 | 0.916 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 1.212360e-01 | 0.916 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.246744e-01 | 0.904 |
| R-HSA-5620971 | Pyroptosis | 1.246744e-01 | 0.904 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.315115e-01 | 0.881 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.315115e-01 | 0.881 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.315115e-01 | 0.881 |
| R-HSA-1266738 | Developmental Biology | 1.413968e-01 | 0.850 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.416689e-01 | 0.849 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.416689e-01 | 0.849 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.416689e-01 | 0.849 |
| R-HSA-390522 | Striated Muscle Contraction | 1.450286e-01 | 0.839 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.450286e-01 | 0.839 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.450286e-01 | 0.839 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.450286e-01 | 0.839 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.483754e-01 | 0.829 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.550303e-01 | 0.810 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.550303e-01 | 0.810 |
| R-HSA-3371511 | HSF1 activation | 1.550303e-01 | 0.810 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.616341e-01 | 0.791 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.649169e-01 | 0.783 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.649169e-01 | 0.783 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.649169e-01 | 0.783 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.649169e-01 | 0.783 |
| R-HSA-3371568 | Attenuation phase | 1.681870e-01 | 0.774 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.681870e-01 | 0.774 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.681870e-01 | 0.774 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.681870e-01 | 0.774 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.697105e-01 | 0.770 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.714446e-01 | 0.766 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.714446e-01 | 0.766 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.760215e-01 | 0.754 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.779220e-01 | 0.750 |
| R-HSA-611105 | Respiratory electron transport | 1.802151e-01 | 0.744 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.843497e-01 | 0.734 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.907278e-01 | 0.720 |
| R-HSA-75153 | Apoptotic execution phase | 1.907278e-01 | 0.720 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.907278e-01 | 0.720 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.938985e-01 | 0.712 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.999774e-01 | 0.699 |
| R-HSA-68877 | Mitotic Prometaphase | 2.013997e-01 | 0.696 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.064593e-01 | 0.685 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.095693e-01 | 0.679 |
| R-HSA-1221632 | Meiotic synapsis | 2.126673e-01 | 0.672 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.218897e-01 | 0.654 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.218897e-01 | 0.654 |
| R-HSA-5663205 | Infectious disease | 2.230218e-01 | 0.652 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.234477e-01 | 0.651 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.249402e-01 | 0.648 |
| R-HSA-191859 | snRNP Assembly | 2.310058e-01 | 0.636 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.310058e-01 | 0.636 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.310058e-01 | 0.636 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.340211e-01 | 0.631 |
| R-HSA-379724 | tRNA Aminoacylation | 2.340211e-01 | 0.631 |
| R-HSA-1280218 | Adaptive Immune System | 2.379459e-01 | 0.624 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.400168e-01 | 0.620 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.518700e-01 | 0.599 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.577282e-01 | 0.589 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.635412e-01 | 0.579 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.664309e-01 | 0.574 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.664309e-01 | 0.574 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.721768e-01 | 0.565 |
| R-HSA-168249 | Innate Immune System | 2.750125e-01 | 0.561 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.778785e-01 | 0.556 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.863486e-01 | 0.543 |
| R-HSA-9659379 | Sensory processing of sound | 2.891502e-01 | 0.539 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.891502e-01 | 0.539 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.919410e-01 | 0.535 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.974902e-01 | 0.527 |
| R-HSA-1500620 | Meiosis | 3.057339e-01 | 0.515 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.057339e-01 | 0.515 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.084606e-01 | 0.511 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.084606e-01 | 0.511 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.138824e-01 | 0.503 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.138824e-01 | 0.503 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.165776e-01 | 0.500 |
| R-HSA-1643685 | Disease | 3.197262e-01 | 0.495 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.246007e-01 | 0.489 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.269958e-01 | 0.485 |
| R-HSA-391251 | Protein folding | 3.298980e-01 | 0.482 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.298980e-01 | 0.482 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.532339e-01 | 0.452 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.583100e-01 | 0.446 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.583100e-01 | 0.446 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.583100e-01 | 0.446 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.757696e-01 | 0.425 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.782254e-01 | 0.422 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.879537e-01 | 0.411 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.892426e-01 | 0.410 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.022659e-01 | 0.395 |
| R-HSA-168256 | Immune System | 4.107972e-01 | 0.386 |
| R-HSA-3371556 | Cellular response to heat stress | 4.116239e-01 | 0.385 |
| R-HSA-1474165 | Reproduction | 4.366212e-01 | 0.360 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.519813e-01 | 0.345 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.587695e-01 | 0.338 |
| R-HSA-877300 | Interferon gamma signaling | 5.015807e-01 | 0.300 |
| R-HSA-5619102 | SLC transporter disorders | 5.171107e-01 | 0.286 |
| R-HSA-6798695 | Neutrophil degranulation | 5.614690e-01 | 0.251 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.678072e-01 | 0.246 |
| R-HSA-112316 | Neuronal System | 5.739453e-01 | 0.241 |
| R-HSA-72172 | mRNA Splicing | 5.862572e-01 | 0.232 |
| R-HSA-397014 | Muscle contraction | 5.991864e-01 | 0.222 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.991864e-01 | 0.222 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.007744e-01 | 0.221 |
| R-HSA-8939211 | ESR-mediated signaling | 6.370807e-01 | 0.196 |
| R-HSA-162582 | Signal Transduction | 6.671062e-01 | 0.176 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.727496e-01 | 0.172 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.393119e-01 | 0.131 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.424192e-01 | 0.129 |
| R-HSA-8957322 | Metabolism of steroids | 7.434469e-01 | 0.129 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.805265e-01 | 0.108 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.092797e-01 | 0.092 |
| R-HSA-109582 | Hemostasis | 8.294506e-01 | 0.081 |
| R-HSA-1430728 | Metabolism | 9.737077e-01 | 0.012 |
| R-HSA-9709957 | Sensory Perception | 9.940513e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.979683e-01 | 0.001 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
BMPR1B |
0.804 | 0.387 | 1 | 0.774 |
MOS |
0.802 | 0.373 | 1 | 0.765 |
ALK2 |
0.798 | 0.383 | -2 | 0.854 |
BMPR1A |
0.796 | 0.378 | 1 | 0.780 |
CLK3 |
0.791 | 0.250 | 1 | 0.663 |
TGFBR1 |
0.791 | 0.273 | -2 | 0.843 |
GRK7 |
0.789 | 0.239 | 1 | 0.628 |
CDC7 |
0.788 | 0.292 | 1 | 0.786 |
ACVR2B |
0.788 | 0.292 | -2 | 0.823 |
GRK1 |
0.787 | 0.289 | -2 | 0.796 |
CK2A2 |
0.785 | 0.306 | 1 | 0.715 |
LATS1 |
0.785 | 0.210 | -3 | 0.800 |
ACVR2A |
0.783 | 0.243 | -2 | 0.816 |
ALK4 |
0.783 | 0.208 | -2 | 0.848 |
GRK6 |
0.783 | 0.219 | 1 | 0.684 |
CAMK2G |
0.781 | 0.140 | 2 | 0.731 |
CAMK2B |
0.780 | 0.240 | 2 | 0.715 |
COT |
0.778 | 0.126 | 2 | 0.712 |
BMPR2 |
0.778 | 0.026 | -2 | 0.821 |
PASK |
0.777 | 0.205 | -3 | 0.797 |
PRPK |
0.777 | -0.016 | -1 | 0.704 |
CAMK2A |
0.776 | 0.231 | 2 | 0.746 |
PIM3 |
0.776 | 0.160 | -3 | 0.798 |
CK2A1 |
0.775 | 0.273 | 1 | 0.693 |
CAMK1B |
0.775 | 0.048 | -3 | 0.828 |
PIM1 |
0.773 | 0.166 | -3 | 0.787 |
RAF1 |
0.773 | 0.003 | 1 | 0.656 |
GAK |
0.773 | 0.202 | 1 | 0.717 |
GRK5 |
0.771 | 0.088 | -3 | 0.780 |
SKMLCK |
0.770 | 0.056 | -2 | 0.714 |
CDKL1 |
0.769 | 0.036 | -3 | 0.757 |
DAPK2 |
0.769 | 0.009 | -3 | 0.814 |
NIK |
0.768 | -0.037 | -3 | 0.831 |
JNK2 |
0.766 | 0.065 | 1 | 0.523 |
ATR |
0.766 | -0.060 | 1 | 0.560 |
GRK2 |
0.766 | 0.086 | -2 | 0.747 |
DSTYK |
0.766 | 0.039 | 2 | 0.757 |
MEK1 |
0.766 | -0.053 | 2 | 0.665 |
CAMLCK |
0.766 | -0.025 | -2 | 0.706 |
NLK |
0.766 | -0.029 | 1 | 0.645 |
CAMK2D |
0.765 | 0.096 | -3 | 0.782 |
FAM20C |
0.765 | 0.187 | 2 | 0.603 |
ERK5 |
0.764 | -0.017 | 1 | 0.643 |
CLK2 |
0.764 | 0.180 | -3 | 0.759 |
ATM |
0.763 | 0.017 | 1 | 0.513 |
JNK3 |
0.763 | 0.049 | 1 | 0.539 |
DLK |
0.762 | -0.096 | 1 | 0.618 |
YSK4 |
0.762 | -0.041 | 1 | 0.592 |
GRK4 |
0.762 | 0.084 | -2 | 0.832 |
MTOR |
0.762 | -0.069 | 1 | 0.593 |
PDHK4 |
0.762 | -0.186 | 1 | 0.641 |
RSK2 |
0.762 | 0.111 | -3 | 0.758 |
IKKB |
0.761 | 0.013 | -2 | 0.669 |
KIS |
0.761 | 0.154 | 1 | 0.565 |
ICK |
0.760 | 0.009 | -3 | 0.781 |
PLK1 |
0.760 | 0.017 | -2 | 0.775 |
MAPKAPK2 |
0.760 | 0.136 | -3 | 0.732 |
PLK3 |
0.760 | 0.053 | 2 | 0.642 |
CLK4 |
0.760 | 0.089 | -3 | 0.781 |
TGFBR2 |
0.759 | 0.058 | -2 | 0.830 |
NUAK2 |
0.759 | 0.033 | -3 | 0.824 |
MST4 |
0.759 | 0.011 | 2 | 0.755 |
NDR2 |
0.758 | 0.120 | -3 | 0.804 |
ANKRD3 |
0.758 | -0.141 | 1 | 0.611 |
P38B |
0.757 | 0.042 | 1 | 0.530 |
LATS2 |
0.757 | 0.103 | -5 | 0.652 |
GSK3A |
0.757 | 0.119 | 4 | 0.540 |
CDK1 |
0.756 | 0.048 | 1 | 0.533 |
TBK1 |
0.756 | -0.107 | 1 | 0.545 |
BRAF |
0.756 | -0.031 | -4 | 0.734 |
IKKA |
0.755 | 0.064 | -2 | 0.681 |
GRK3 |
0.755 | 0.097 | -2 | 0.737 |
SRPK1 |
0.755 | 0.064 | -3 | 0.726 |
CDKL5 |
0.755 | 0.019 | -3 | 0.745 |
TLK1 |
0.755 | 0.005 | -2 | 0.844 |
PKR |
0.754 | -0.131 | 1 | 0.592 |
PLK2 |
0.754 | 0.098 | -3 | 0.734 |
PDHK1 |
0.754 | -0.206 | 1 | 0.624 |
P38A |
0.754 | 0.013 | 1 | 0.574 |
MEKK3 |
0.753 | -0.096 | 1 | 0.600 |
GCK |
0.753 | -0.008 | 1 | 0.603 |
CHK1 |
0.753 | 0.048 | -3 | 0.789 |
RSK4 |
0.753 | 0.111 | -3 | 0.738 |
HIPK4 |
0.753 | 0.039 | 1 | 0.567 |
PKN3 |
0.753 | -0.033 | -3 | 0.770 |
IKKE |
0.752 | -0.105 | 1 | 0.545 |
VRK2 |
0.752 | -0.321 | 1 | 0.641 |
P90RSK |
0.752 | 0.054 | -3 | 0.748 |
GSK3B |
0.752 | 0.082 | 4 | 0.531 |
JNK1 |
0.752 | 0.044 | 1 | 0.520 |
MST2 |
0.752 | -0.019 | 1 | 0.619 |
MASTL |
0.752 | -0.208 | -2 | 0.715 |
TLK2 |
0.752 | -0.052 | 1 | 0.518 |
DNAPK |
0.752 | -0.012 | 1 | 0.426 |
CLK1 |
0.752 | 0.090 | -3 | 0.765 |
P70S6KB |
0.751 | 0.022 | -3 | 0.788 |
DYRK2 |
0.751 | 0.034 | 1 | 0.550 |
TAO3 |
0.750 | -0.041 | 1 | 0.597 |
WNK1 |
0.750 | -0.073 | -2 | 0.718 |
MLK1 |
0.750 | -0.133 | 2 | 0.685 |
MARK4 |
0.750 | -0.051 | 4 | 0.762 |
MYLK4 |
0.750 | 0.021 | -2 | 0.615 |
CHAK2 |
0.750 | -0.074 | -1 | 0.706 |
TAK1 |
0.749 | -0.022 | 1 | 0.586 |
ALPHAK3 |
0.749 | 0.124 | -1 | 0.664 |
MAPKAPK3 |
0.749 | 0.033 | -3 | 0.753 |
PRKD1 |
0.749 | 0.045 | -3 | 0.759 |
CDK8 |
0.749 | 0.013 | 1 | 0.546 |
AMPKA1 |
0.749 | -0.031 | -3 | 0.822 |
PIM2 |
0.749 | 0.075 | -3 | 0.745 |
DYRK4 |
0.748 | 0.074 | 1 | 0.521 |
MSK1 |
0.748 | 0.058 | -3 | 0.727 |
RIPK3 |
0.748 | -0.137 | 3 | 0.590 |
HIPK1 |
0.748 | 0.039 | 1 | 0.566 |
MST3 |
0.748 | -0.053 | 2 | 0.715 |
P38G |
0.747 | 0.019 | 1 | 0.478 |
SRPK3 |
0.747 | 0.023 | -3 | 0.703 |
NDR1 |
0.747 | 0.005 | -3 | 0.809 |
P38D |
0.746 | 0.051 | 1 | 0.480 |
PKCD |
0.746 | -0.025 | 2 | 0.676 |
TSSK2 |
0.746 | -0.048 | -5 | 0.732 |
DAPK3 |
0.746 | 0.030 | -3 | 0.801 |
DRAK1 |
0.746 | -0.021 | 1 | 0.585 |
DAPK1 |
0.746 | 0.040 | -3 | 0.784 |
MST1 |
0.746 | -0.039 | 1 | 0.582 |
GCN2 |
0.745 | -0.109 | 2 | 0.633 |
SMMLCK |
0.745 | -0.039 | -3 | 0.784 |
CK1D |
0.745 | 0.091 | -3 | 0.559 |
HUNK |
0.745 | -0.158 | 2 | 0.601 |
CAMK4 |
0.744 | -0.039 | -3 | 0.817 |
HIPK2 |
0.744 | 0.064 | 1 | 0.498 |
MEK5 |
0.744 | -0.293 | 2 | 0.652 |
MEKK2 |
0.744 | -0.188 | 2 | 0.626 |
ERK1 |
0.743 | 0.007 | 1 | 0.523 |
CDK17 |
0.743 | 0.021 | 1 | 0.477 |
PKN2 |
0.743 | -0.060 | -3 | 0.813 |
NEK7 |
0.743 | -0.181 | -3 | 0.745 |
PRKD2 |
0.742 | 0.067 | -3 | 0.759 |
ERK2 |
0.742 | -0.024 | 1 | 0.529 |
DCAMKL1 |
0.742 | 0.015 | -3 | 0.795 |
HPK1 |
0.742 | -0.052 | 1 | 0.589 |
SRPK2 |
0.741 | 0.058 | -3 | 0.671 |
SMG1 |
0.741 | -0.068 | 1 | 0.499 |
PERK |
0.741 | -0.115 | -2 | 0.808 |
TSSK1 |
0.741 | -0.031 | -3 | 0.825 |
CDK3 |
0.741 | 0.033 | 1 | 0.500 |
MSK2 |
0.741 | 0.000 | -3 | 0.720 |
CDK2 |
0.741 | -0.023 | 1 | 0.581 |
PKACG |
0.740 | -0.004 | -2 | 0.610 |
CK1E |
0.740 | 0.074 | -3 | 0.604 |
TAO2 |
0.740 | -0.122 | 2 | 0.713 |
PRP4 |
0.740 | -0.057 | -3 | 0.630 |
CDK18 |
0.740 | 0.023 | 1 | 0.515 |
EEF2K |
0.739 | -0.069 | 3 | 0.621 |
NEK6 |
0.739 | -0.130 | -2 | 0.806 |
CDK19 |
0.739 | 0.014 | 1 | 0.524 |
AMPKA2 |
0.739 | -0.028 | -3 | 0.808 |
PKACB |
0.739 | 0.059 | -2 | 0.532 |
RIPK1 |
0.739 | -0.251 | 1 | 0.544 |
MLK2 |
0.738 | -0.244 | 2 | 0.652 |
PRKX |
0.738 | 0.126 | -3 | 0.728 |
MPSK1 |
0.738 | -0.038 | 1 | 0.616 |
TTBK2 |
0.738 | -0.152 | 2 | 0.497 |
SBK |
0.738 | 0.088 | -3 | 0.607 |
RSK3 |
0.738 | 0.007 | -3 | 0.740 |
MLK3 |
0.738 | -0.087 | 2 | 0.645 |
CDK5 |
0.737 | -0.012 | 1 | 0.575 |
CDK7 |
0.737 | -0.018 | 1 | 0.566 |
DCAMKL2 |
0.737 | -0.017 | -3 | 0.818 |
CDK14 |
0.737 | 0.007 | 1 | 0.545 |
DYRK1A |
0.737 | 0.010 | 1 | 0.572 |
NEK9 |
0.737 | -0.273 | 2 | 0.656 |
PBK |
0.736 | 0.050 | 1 | 0.683 |
CAMK1D |
0.736 | 0.037 | -3 | 0.711 |
CK1A2 |
0.736 | 0.056 | -3 | 0.565 |
HRI |
0.736 | -0.185 | -2 | 0.804 |
WNK3 |
0.736 | -0.269 | 1 | 0.563 |
AURA |
0.735 | -0.021 | -2 | 0.499 |
ULK2 |
0.735 | -0.292 | 2 | 0.600 |
DMPK1 |
0.735 | 0.060 | -3 | 0.782 |
NEK11 |
0.735 | -0.230 | 1 | 0.564 |
DYRK1B |
0.735 | 0.013 | 1 | 0.546 |
NEK5 |
0.735 | -0.230 | 1 | 0.569 |
MEKK1 |
0.735 | -0.261 | 1 | 0.575 |
AURC |
0.735 | 0.014 | -2 | 0.519 |
BCKDK |
0.735 | -0.172 | -1 | 0.598 |
ZAK |
0.735 | -0.228 | 1 | 0.556 |
NEK8 |
0.734 | -0.206 | 2 | 0.671 |
MLK4 |
0.734 | -0.131 | 2 | 0.591 |
MARK2 |
0.734 | -0.051 | 4 | 0.688 |
HIPK3 |
0.734 | -0.012 | 1 | 0.562 |
MARK3 |
0.734 | -0.031 | 4 | 0.698 |
MINK |
0.733 | -0.170 | 1 | 0.573 |
CDK13 |
0.733 | -0.037 | 1 | 0.540 |
PAK1 |
0.733 | -0.069 | -2 | 0.618 |
CDK16 |
0.733 | 0.026 | 1 | 0.490 |
PRKD3 |
0.733 | -0.008 | -3 | 0.743 |
TNIK |
0.733 | -0.123 | 3 | 0.650 |
SGK3 |
0.732 | -0.024 | -3 | 0.743 |
CAMKK2 |
0.732 | -0.198 | -2 | 0.619 |
MRCKA |
0.732 | 0.029 | -3 | 0.766 |
CDK10 |
0.732 | 0.031 | 1 | 0.532 |
LRRK2 |
0.731 | -0.221 | 2 | 0.690 |
QSK |
0.731 | -0.051 | 4 | 0.730 |
BIKE |
0.731 | 0.084 | 1 | 0.669 |
AURB |
0.731 | -0.034 | -2 | 0.513 |
KHS1 |
0.731 | -0.088 | 1 | 0.566 |
SLK |
0.731 | -0.055 | -2 | 0.638 |
KHS2 |
0.731 | -0.063 | 1 | 0.574 |
MAK |
0.731 | 0.046 | -2 | 0.592 |
ROCK2 |
0.730 | 0.011 | -3 | 0.785 |
PDK1 |
0.730 | -0.190 | 1 | 0.549 |
TTK |
0.730 | -0.031 | -2 | 0.816 |
AKT2 |
0.729 | -0.001 | -3 | 0.707 |
MARK1 |
0.729 | -0.058 | 4 | 0.711 |
MAP3K15 |
0.729 | -0.229 | 1 | 0.548 |
NUAK1 |
0.729 | -0.042 | -3 | 0.792 |
CAMKK1 |
0.729 | -0.241 | -2 | 0.637 |
LKB1 |
0.729 | -0.202 | -3 | 0.724 |
HGK |
0.729 | -0.178 | 3 | 0.643 |
CAMK1G |
0.729 | -0.047 | -3 | 0.759 |
ERK7 |
0.729 | -0.020 | 2 | 0.470 |
PAK2 |
0.729 | -0.119 | -2 | 0.608 |
DYRK3 |
0.728 | -0.007 | 1 | 0.558 |
PKCA |
0.727 | -0.072 | 2 | 0.631 |
BRSK1 |
0.727 | -0.017 | -3 | 0.777 |
QIK |
0.727 | -0.141 | -3 | 0.796 |
PKCB |
0.727 | -0.057 | 2 | 0.631 |
PKCG |
0.727 | -0.067 | 2 | 0.638 |
SIK |
0.727 | -0.037 | -3 | 0.774 |
ULK1 |
0.727 | -0.256 | -3 | 0.714 |
CDK12 |
0.726 | -0.045 | 1 | 0.515 |
NEK2 |
0.726 | -0.248 | 2 | 0.645 |
PKACA |
0.725 | 0.033 | -2 | 0.480 |
WNK4 |
0.725 | -0.230 | -2 | 0.715 |
CDK9 |
0.725 | -0.049 | 1 | 0.545 |
MELK |
0.725 | -0.094 | -3 | 0.792 |
PINK1 |
0.725 | -0.223 | 1 | 0.605 |
PKCH |
0.724 | -0.101 | 2 | 0.606 |
PAK3 |
0.723 | -0.133 | -2 | 0.606 |
MNK1 |
0.723 | -0.038 | -2 | 0.640 |
VRK1 |
0.723 | -0.297 | 2 | 0.656 |
MRCKB |
0.723 | -0.003 | -3 | 0.752 |
NEK4 |
0.722 | -0.261 | 1 | 0.549 |
PKG2 |
0.722 | -0.030 | -2 | 0.534 |
OSR1 |
0.722 | -0.128 | 2 | 0.619 |
MAPKAPK5 |
0.722 | -0.081 | -3 | 0.679 |
PLK4 |
0.722 | -0.186 | 2 | 0.451 |
NIM1 |
0.722 | -0.190 | 3 | 0.617 |
NEK1 |
0.721 | -0.255 | 1 | 0.550 |
CHK2 |
0.721 | -0.006 | -3 | 0.671 |
SGK1 |
0.721 | 0.017 | -3 | 0.634 |
MEKK6 |
0.721 | -0.280 | 1 | 0.573 |
IRE2 |
0.721 | -0.192 | 2 | 0.617 |
LOK |
0.721 | -0.136 | -2 | 0.645 |
AAK1 |
0.720 | 0.121 | 1 | 0.612 |
P70S6K |
0.720 | -0.030 | -3 | 0.704 |
IRE1 |
0.720 | -0.250 | 1 | 0.530 |
ASK1 |
0.720 | -0.211 | 1 | 0.547 |
PHKG1 |
0.719 | -0.106 | -3 | 0.810 |
PKCZ |
0.719 | -0.150 | 2 | 0.623 |
MOK |
0.718 | -0.003 | 1 | 0.562 |
MEK2 |
0.718 | -0.303 | 2 | 0.612 |
CHAK1 |
0.718 | -0.270 | 2 | 0.580 |
BUB1 |
0.718 | -0.034 | -5 | 0.656 |
YSK1 |
0.717 | -0.205 | 2 | 0.659 |
TTBK1 |
0.716 | -0.163 | 2 | 0.439 |
CRIK |
0.716 | 0.005 | -3 | 0.699 |
BRSK2 |
0.716 | -0.094 | -3 | 0.794 |
CAMK1A |
0.716 | -0.006 | -3 | 0.687 |
SSTK |
0.716 | -0.085 | 4 | 0.713 |
AKT1 |
0.715 | -0.029 | -3 | 0.723 |
CDK6 |
0.714 | -0.043 | 1 | 0.532 |
PDHK3_TYR |
0.714 | 0.301 | 4 | 0.825 |
MNK2 |
0.713 | -0.110 | -2 | 0.620 |
PKCE |
0.713 | -0.046 | 2 | 0.628 |
YANK3 |
0.712 | -0.047 | 2 | 0.309 |
RIPK2 |
0.712 | -0.256 | 1 | 0.538 |
ROCK1 |
0.712 | -0.028 | -3 | 0.766 |
CK1G1 |
0.712 | -0.001 | -3 | 0.597 |
IRAK4 |
0.711 | -0.289 | 1 | 0.530 |
SNRK |
0.710 | -0.214 | 2 | 0.536 |
MAP2K6_TYR |
0.710 | 0.238 | -1 | 0.725 |
CDK4 |
0.709 | -0.051 | 1 | 0.503 |
PKCI |
0.709 | -0.122 | 2 | 0.617 |
PAK6 |
0.708 | -0.059 | -2 | 0.512 |
MYO3A |
0.708 | -0.189 | 1 | 0.537 |
HASPIN |
0.707 | -0.111 | -1 | 0.548 |
PDHK4_TYR |
0.707 | 0.191 | 2 | 0.760 |
PDHK1_TYR |
0.707 | 0.168 | -1 | 0.733 |
MAP2K4_TYR |
0.706 | 0.186 | -1 | 0.727 |
TAO1 |
0.705 | -0.172 | 1 | 0.522 |
PKCT |
0.704 | -0.141 | 2 | 0.606 |
STLK3 |
0.704 | -0.245 | 1 | 0.542 |
IRAK1 |
0.704 | -0.361 | -1 | 0.552 |
BMPR2_TYR |
0.703 | 0.094 | -1 | 0.737 |
PHKG2 |
0.702 | -0.096 | -3 | 0.812 |
MYO3B |
0.702 | -0.222 | 2 | 0.686 |
EPHA4 |
0.701 | 0.175 | 2 | 0.670 |
AKT3 |
0.701 | -0.015 | -3 | 0.645 |
PKN1 |
0.698 | -0.081 | -3 | 0.724 |
TESK1_TYR |
0.697 | -0.016 | 3 | 0.723 |
STK33 |
0.696 | -0.239 | 2 | 0.459 |
EPHA6 |
0.696 | 0.105 | -1 | 0.720 |
MAP2K7_TYR |
0.695 | -0.093 | 2 | 0.714 |
CK1A |
0.694 | 0.046 | -3 | 0.488 |
PAK5 |
0.693 | -0.102 | -2 | 0.485 |
TXK |
0.693 | 0.141 | 1 | 0.740 |
PKMYT1_TYR |
0.692 | -0.078 | 3 | 0.704 |
NEK3 |
0.692 | -0.341 | 1 | 0.525 |
PTK2 |
0.692 | 0.140 | -1 | 0.716 |
CK1G2 |
0.691 | 0.053 | -3 | 0.528 |
SRMS |
0.691 | 0.111 | 1 | 0.722 |
EPHB4 |
0.690 | 0.067 | -1 | 0.696 |
SYK |
0.690 | 0.183 | -1 | 0.686 |
CK1G3 |
0.689 | 0.018 | -3 | 0.447 |
YANK2 |
0.688 | -0.067 | 2 | 0.324 |
PAK4 |
0.688 | -0.100 | -2 | 0.490 |
EPHB2 |
0.688 | 0.120 | -1 | 0.674 |
PINK1_TYR |
0.688 | -0.152 | 1 | 0.629 |
FYN |
0.687 | 0.105 | -1 | 0.675 |
FER |
0.685 | 0.033 | 1 | 0.722 |
EPHA5 |
0.684 | 0.132 | 2 | 0.654 |
INSRR |
0.684 | -0.000 | 3 | 0.582 |
FGR |
0.683 | -0.011 | 1 | 0.672 |
YES1 |
0.683 | 0.005 | -1 | 0.684 |
EPHB1 |
0.683 | 0.041 | 1 | 0.705 |
EPHB3 |
0.682 | 0.059 | -1 | 0.667 |
EPHA3 |
0.680 | 0.012 | 2 | 0.634 |
LIMK2_TYR |
0.680 | -0.122 | -3 | 0.803 |
EPHA7 |
0.678 | 0.041 | 2 | 0.646 |
BLK |
0.678 | 0.061 | -1 | 0.678 |
HCK |
0.677 | -0.031 | -1 | 0.676 |
LCK |
0.677 | 0.023 | -1 | 0.679 |
PKG1 |
0.676 | -0.082 | -2 | 0.458 |
DDR1 |
0.676 | -0.161 | 4 | 0.738 |
FGFR2 |
0.676 | -0.097 | 3 | 0.664 |
FLT1 |
0.675 | -0.024 | -1 | 0.708 |
PTK2B |
0.675 | 0.014 | -1 | 0.589 |
BMX |
0.674 | -0.002 | -1 | 0.607 |
LIMK1_TYR |
0.674 | -0.245 | 2 | 0.692 |
EPHA8 |
0.674 | 0.021 | -1 | 0.652 |
MST1R |
0.673 | -0.217 | 3 | 0.644 |
RET |
0.673 | -0.228 | 1 | 0.565 |
FGFR3 |
0.673 | -0.060 | 3 | 0.644 |
EPHA2 |
0.672 | 0.059 | -1 | 0.660 |
TNK2 |
0.672 | -0.090 | 3 | 0.609 |
MERTK |
0.671 | -0.047 | 3 | 0.636 |
JAK3 |
0.671 | -0.146 | 1 | 0.559 |
ITK |
0.671 | -0.050 | -1 | 0.638 |
SRC |
0.670 | -0.004 | -1 | 0.655 |
NTRK1 |
0.670 | -0.112 | -1 | 0.668 |
EGFR |
0.670 | -0.029 | 1 | 0.494 |
CSF1R |
0.669 | -0.180 | 3 | 0.623 |
TYRO3 |
0.669 | -0.192 | 3 | 0.598 |
KIT |
0.669 | -0.132 | 3 | 0.635 |
ABL2 |
0.668 | -0.092 | -1 | 0.639 |
TEC |
0.668 | -0.036 | -1 | 0.592 |
ERBB2 |
0.668 | -0.116 | 1 | 0.565 |
ERBB4 |
0.668 | 0.010 | 1 | 0.544 |
MET |
0.668 | -0.092 | 3 | 0.631 |
JAK2 |
0.667 | -0.265 | 1 | 0.561 |
TYK2 |
0.667 | -0.321 | 1 | 0.567 |
ABL1 |
0.667 | -0.104 | -1 | 0.627 |
ROS1 |
0.666 | -0.220 | 3 | 0.559 |
LYN |
0.666 | -0.037 | 3 | 0.547 |
KDR |
0.665 | -0.146 | 3 | 0.603 |
FGFR4 |
0.664 | -0.055 | -1 | 0.637 |
TEK |
0.664 | -0.133 | 3 | 0.559 |
LTK |
0.663 | -0.120 | 3 | 0.596 |
FGFR1 |
0.663 | -0.188 | 3 | 0.607 |
NTRK3 |
0.662 | -0.109 | -1 | 0.627 |
FRK |
0.662 | -0.071 | -1 | 0.678 |
BTK |
0.662 | -0.145 | -1 | 0.608 |
AXL |
0.661 | -0.165 | 3 | 0.617 |
EPHA1 |
0.660 | -0.101 | 3 | 0.604 |
NEK10_TYR |
0.660 | -0.197 | 1 | 0.485 |
PTK6 |
0.660 | -0.164 | -1 | 0.561 |
FLT3 |
0.660 | -0.214 | 3 | 0.596 |
CSK |
0.659 | -0.117 | 2 | 0.642 |
FLT4 |
0.659 | -0.172 | 3 | 0.618 |
ALK |
0.658 | -0.154 | 3 | 0.544 |
INSR |
0.657 | -0.150 | 3 | 0.555 |
IGF1R |
0.656 | -0.083 | 3 | 0.513 |
NTRK2 |
0.656 | -0.201 | 3 | 0.586 |
PDGFRB |
0.656 | -0.279 | 3 | 0.614 |
JAK1 |
0.655 | -0.211 | 1 | 0.528 |
ZAP70 |
0.655 | 0.021 | -1 | 0.609 |
WEE1_TYR |
0.655 | -0.178 | -1 | 0.600 |
DDR2 |
0.655 | -0.097 | 3 | 0.585 |
MATK |
0.654 | -0.122 | -1 | 0.572 |
TNK1 |
0.649 | -0.259 | 3 | 0.600 |
FES |
0.648 | -0.068 | -1 | 0.569 |
PDGFRA |
0.646 | -0.344 | 3 | 0.605 |
TNNI3K_TYR |
0.644 | -0.251 | 1 | 0.558 |
MUSK |
0.634 | -0.205 | 1 | 0.496 |