Motif 1181 (n=102)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVT1 | UBA6 | S16 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| A8MQ03 | CYSRT1 | S16 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| C9JLW8 | MCRIP1 | T16 | ochoa | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}. |
| O14949 | UQCRQ | S16 | ochoa | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P08525}. |
| O60437 | PPL | T16 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O75381 | PEX14 | T16 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O94782 | USP1 | S16 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| P02686 | MBP | S16 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P07947 | YES1 | Y16 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P14317 | HCLS1 | T16 | ochoa|psp | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14649 | MYL6B | S16 | ochoa | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| P16383 | GCFC2 | S16 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P16949 | STMN1 | S16 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P19086 | GNAZ | S16 | psp | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| P26678 | PLN | S16 | ochoa|psp | Phospholamban (PLB) | Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity). {ECO:0000250|UniProtKB:P61012, ECO:0000250|UniProtKB:P61014, ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725, ECO:0000269|PubMed:28890335}. |
| P29350 | PTPN6 | T16 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P35610 | SOAT1 | S16 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P41091 | EIF2S3 | S16 | ochoa | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P51580 | TPMT | T16 | ochoa | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}. |
| P54707 | ATP12A | T16 | ochoa | Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) | The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:11341842, PubMed:7485470, PubMed:8853415, PubMed:9774385). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}. |
| P61011 | SRP54 | S16 | ochoa | Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977). {ECO:0000250|UniProtKB:P61010, ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. |
| P98175 | RBM10 | Y16 | psp | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q07960 | ARHGAP1 | T16 | ochoa | Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) | GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. |
| Q08378 | GOLGA3 | S16 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08495 | DMTN | S16 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q13287 | NMI | S16 | ochoa | N-myc-interactor (Nmi) (N-myc and STAT interactor) | Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250|UniProtKB:O35309, ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881, ECO:0000269|PubMed:9989503}. |
| Q13322 | GRB10 | Y16 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13576 | IQGAP2 | S16 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q14166 | TTLL12 | S16 | ochoa | Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12) | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). {ECO:0000269|PubMed:20162578, ECO:0000269|PubMed:23251473, ECO:0000269|PubMed:28011935}. |
| Q14914 | PTGR1 | Y16 | ochoa | Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74) | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}. |
| Q15173 | PPP2R5B | S16 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}. |
| Q15382 | RHEB | S16 | ochoa | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q15427 | SF3B4 | Y16 | ochoa | Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}. |
| Q2VIR3 | EIF2S3B | S16 | ochoa | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| Q5T4F4 | ZFYVE27 | S16 | ochoa | Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) | Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:17082457, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:21976701, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}. |
| Q5VYS4 | MEDAG | S16 | ochoa | Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4) | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}. |
| Q6P2H3 | CEP85 | T16 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6ZMT1 | STAC2 | T16 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
| Q6ZPD9 | DPY19L3 | S16 | ochoa | Protein C-mannosyl-transferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) | C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:26764097, PubMed:29405629). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (PubMed:26764097, PubMed:29405629). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (By similarity). {ECO:0000250|UniProtKB:Q71B07, ECO:0000269|PubMed:26764097, ECO:0000269|PubMed:29405629}.; FUNCTION: [Isoform 2]: Has no C-mannosyltransferase activity. {ECO:0000269|PubMed:29405629}. |
| Q6ZQN7 | SLCO4C1 | S16 | ochoa | Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}. |
| Q6ZWE6 | PLEKHM3 | T16 | ochoa | Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}. |
| Q7L4I2 | RSRC2 | T16 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7L9B9 | EEPD1 | S16 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q86U86 | PBRM1 | S16 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86WQ0 | NR2C2AP | S16 | ochoa | Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein) | May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}. |
| Q86XR7 | TICAM2 | S16 | psp | TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) | Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). {ECO:0000269|PubMed:16603631, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:22685567, ECO:0000269|PubMed:25385819, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:30883606}.; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
| Q8IY26 | PLPP6 | S16 | ochoa | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}. |
| Q8N5V2 | NGEF | S16 | ochoa|psp | Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}. |
| Q8NEU8 | APPL2 | S16 | ochoa | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:15016378, PubMed:24879834, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:24879834). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity) (PubMed:19433865). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}. |
| Q8WVM7 | STAG1 | T16 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WXS3 | BAALC | Y16 | ochoa | Brain and acute leukemia cytoplasmic protein | May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}. |
| Q92629 | SGCD | S16 | ochoa | Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
| Q92674 | CENPI | T16 | ochoa | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}. |
| Q96AY4 | TTC28 | T16 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96BQ5 | CCDC127 | S16 | ochoa | Coiled-coil domain-containing protein 127 | None |
| Q96GD4 | AURKB | T16 | ochoa | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| Q96GX8 | C16orf74 | S16 | ochoa | Uncharacterized protein C16orf74 | None |
| Q96HU1 | SGSM3 | T16 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96QD9 | FYTTD1 | S16 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q99956 | DUSP9 | S16 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q99966 | CITED1 | S16 | ochoa | Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}. |
| Q9BSJ6 | PIMREG | S16 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BUR4 | WRAP53 | S16 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BWH2 | FUNDC2 | T16 | ochoa | FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6) | Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}. |
| Q9BWQ6 | YIPF2 | T16 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9H0G5 | NSRP1 | T16 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H2D1 | SLC25A32 | T16 | ochoa | Solute carrier family 25 member 32 (Mitochondrial FAD transporter) | Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis. {ECO:0000269|PubMed:16165386, ECO:0000269|PubMed:29666258, ECO:0000269|PubMed:35727412}. |
| Q9H2G4 | TSPYL2 | S16 | ochoa | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
| Q9H3Y8 | PPDPF | Y16 | ochoa|psp | Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor) | Probable regulator of exocrine pancreas development. {ECO:0000250}. |
| Q9H4L5 | OSBPL3 | S16 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H583 | HEATR1 | S16 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9HB90 | RRAGC | Y16 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9HC35 | EML4 | S16 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NRA2 | SLC17A5 | S16 | ochoa | Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) | Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity) (PubMed:21781115, PubMed:22778404, PubMed:23889254). {ECO:0000250|UniProtKB:Q5Q0U0, ECO:0000250|UniProtKB:Q8BN82, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404, ECO:0000269|PubMed:23889254}.; FUNCTION: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. {ECO:0000250|UniProtKB:Q9MZD1}. |
| Q9NWQ4 | GPATCH2L | S16 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NX09 | DDIT4 | S16 | ochoa | DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1) | Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753, ECO:0000269|PubMed:21460850}. |
| Q9UBN7 | HDAC6 | S16 | ochoa | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UDV6 | ZNF212 | T16 | ochoa | Zinc finger protein 212 (Zinc finger protein C2H2-150) | May be involved in transcriptional regulation. |
| Q9UJF2 | RASAL2 | S16 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKG1 | APPL1 | S16 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKK9 | NUDT5 | Y16 | ochoa | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
| Q9UN81 | L1RE1 | S16 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9Y3C1 | NOP16 | S16 | ochoa | Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3) | None |
| Q9Y3Q8 | TSC22D4 | T16 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y534 | CSDC2 | S16 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q9Y5B6 | PAXBP1 | S16 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| P50914 | RPL14 | S16 | Sugiyama | Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q14790 | CASP8 | S16 | Sugiyama | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| O14965 | AURKA | T16 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| Q13066 | GAGE2B | Y16 | Sugiyama | G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. |
| Q6NT46 | GAGE2A | Y16 | Sugiyama | G antigen 2A (GAGE-2A) | None |
| Q6QNY0 | BLOC1S3 | T16 | Sugiyama | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| P35611 | ADD1 | T16 | Sugiyama | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| Q13371 | PDCL | Y16 | Sugiyama | Phosducin-like protein (PHLP) | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}.; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. |
| Q15746 | MYLK | S16 | ELM | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q9NZZ3 | CHMP5 | S16 | Sugiyama | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| P48163 | ME1 | Y16 | Sugiyama | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| Q9NZL9 | MAT2B | S16 | Sugiyama | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| P17987 | TCP1 | T16 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q8TF76 | HASPIN | Y16 | Sugiyama | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8IWL2 | SFTPA1 | S16 | Sugiyama | Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4) | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). {ECO:0000250|UniProtKB:P35242}.; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169). {ECO:0000269|PubMed:17158455, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:21203928}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904). When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904). {ECO:0000269|PubMed:15845487, ECO:0000269|PubMed:25139904}. |
| Q9NR20 | DYRK4 | S16 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) | Possible non-essential role in spermiogenesis. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.000079 | 4.102 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.000110 | 3.958 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.000165 | 3.782 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.000339 | 3.470 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.001640 | 2.785 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.001640 | 2.785 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.001766 | 2.753 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.001261 | 2.899 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.001336 | 2.874 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.002538 | 2.596 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.003619 | 2.441 |
| R-HSA-210990 | PECAM1 interactions | 0.004880 | 2.312 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.006467 | 2.189 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.006313 | 2.200 |
| R-HSA-5683826 | Surfactant metabolism | 0.006819 | 2.166 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 0.007301 | 2.137 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.007914 | 2.102 |
| R-HSA-2262752 | Cellular responses to stress | 0.009129 | 2.040 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.009678 | 2.014 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.014550 | 1.837 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.014550 | 1.837 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.014550 | 1.837 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.014550 | 1.837 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.014550 | 1.837 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.014768 | 1.831 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.012430 | 1.906 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.012619 | 1.899 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.014976 | 1.825 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.017830 | 1.749 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.018264 | 1.738 |
| R-HSA-5578995 | Defective TPMT causes TPMT deficiency | 0.021746 | 1.663 |
| R-HSA-5619035 | Defective SLC17A5 causes Salla disease (SD) and ISSD | 0.021746 | 1.663 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.028889 | 1.539 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.056951 | 1.244 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.070679 | 1.151 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.070679 | 1.151 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.077468 | 1.111 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.077468 | 1.111 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.084209 | 1.075 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.084209 | 1.075 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.090900 | 1.041 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.090900 | 1.041 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.097543 | 1.011 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.097543 | 1.011 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.097543 | 1.011 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.104138 | 0.982 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.104138 | 0.982 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.110685 | 0.956 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.110685 | 0.956 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.110685 | 0.956 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.110685 | 0.956 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.110685 | 0.956 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.130042 | 0.886 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.130042 | 0.886 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.035225 | 1.453 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.036836 | 1.434 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.161381 | 0.792 |
| R-HSA-72187 | mRNA 3'-end processing | 0.072197 | 1.141 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.197513 | 0.704 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.032337 | 1.490 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.032337 | 1.490 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.226441 | 0.645 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.020747 | 1.683 |
| R-HSA-72172 | mRNA Splicing | 0.025074 | 1.601 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.291717 | 0.535 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.217119 | 0.663 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.219800 | 0.658 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.034090 | 1.467 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.142715 | 0.846 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.237720 | 0.624 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.237720 | 0.624 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.097543 | 1.011 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.259792 | 0.585 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.056951 | 1.244 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.024778 | 1.606 |
| R-HSA-9857492 | Protein lipoylation | 0.130042 | 0.886 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.246744 | 0.608 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.246744 | 0.608 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.220739 | 0.656 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.043022 | 1.366 |
| R-HSA-6783984 | Glycine degradation | 0.142715 | 0.846 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.074278 | 1.129 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.219800 | 0.658 |
| R-HSA-391251 | Protein folding | 0.039639 | 1.402 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.185644 | 0.731 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.023256 | 1.633 |
| R-HSA-9865881 | Complex III assembly | 0.197513 | 0.704 |
| R-HSA-6798695 | Neutrophil degranulation | 0.273623 | 0.563 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.048764 | 1.312 |
| R-HSA-68877 | Mitotic Prometaphase | 0.020380 | 1.691 |
| R-HSA-165159 | MTOR signalling | 0.052524 | 1.280 |
| R-HSA-4839744 | Signaling by APC mutants | 0.097543 | 1.011 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.104138 | 0.982 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.104138 | 0.982 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.104138 | 0.982 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.136402 | 0.865 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.185644 | 0.731 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.191600 | 0.718 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.197513 | 0.704 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.074278 | 1.129 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.237720 | 0.624 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.243299 | 0.614 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.119446 | 0.923 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.265210 | 0.576 |
| R-HSA-9711097 | Cellular response to starvation | 0.041149 | 1.386 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.155204 | 0.809 |
| R-HSA-9646399 | Aggrephagy | 0.291717 | 0.535 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.161381 | 0.792 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.243299 | 0.614 |
| R-HSA-73886 | Chromosome Maintenance | 0.077559 | 1.110 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.084209 | 1.075 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.074278 | 1.129 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.045542 | 1.342 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.206425 | 0.685 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.225171 | 0.647 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.225171 | 0.647 |
| R-HSA-74713 | IRS activation | 0.050012 | 1.301 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.173601 | 0.760 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.209211 | 0.679 |
| R-HSA-157579 | Telomere Maintenance | 0.187868 | 0.726 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.090900 | 1.041 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.029074 | 1.536 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.214996 | 0.668 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.034390 | 1.464 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.185644 | 0.731 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.028889 | 1.539 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.050012 | 1.301 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.084209 | 1.075 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.110685 | 0.956 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.214996 | 0.668 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.091588 | 1.038 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.226441 | 0.645 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.172165 | 0.764 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.070679 | 1.151 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.035982 | 1.444 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.123637 | 0.908 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.167513 | 0.776 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.185644 | 0.731 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.248836 | 0.604 |
| R-HSA-9612973 | Autophagy | 0.136279 | 0.866 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.248836 | 0.604 |
| R-HSA-8852135 | Protein ubiquitination | 0.124275 | 0.906 |
| R-HSA-68886 | M Phase | 0.174705 | 0.758 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.136402 | 0.865 |
| R-HSA-381042 | PERK regulates gene expression | 0.265210 | 0.576 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.281230 | 0.551 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.069359 | 1.159 |
| R-HSA-397014 | Muscle contraction | 0.242209 | 0.616 |
| R-HSA-75158 | TRAIL signaling | 0.056951 | 1.244 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.084209 | 1.075 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.123637 | 0.908 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.191600 | 0.718 |
| R-HSA-5673000 | RAF activation | 0.259792 | 0.585 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.057661 | 1.239 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.052524 | 1.280 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.064070 | 1.193 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.057661 | 1.239 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.036836 | 1.434 |
| R-HSA-156581 | Methylation | 0.056282 | 1.250 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.141531 | 0.849 |
| R-HSA-8953854 | Metabolism of RNA | 0.291409 | 0.535 |
| R-HSA-74749 | Signal attenuation | 0.090900 | 1.041 |
| R-HSA-3371511 | HSF1 activation | 0.270589 | 0.568 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.089364 | 1.049 |
| R-HSA-1640170 | Cell Cycle | 0.087859 | 1.056 |
| R-HSA-109581 | Apoptosis | 0.044049 | 1.356 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.084209 | 1.075 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.026179 | 1.582 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.155204 | 0.809 |
| R-HSA-1632852 | Macroautophagy | 0.110613 | 0.956 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.270589 | 0.568 |
| R-HSA-5357801 | Programmed Cell Death | 0.084306 | 1.074 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.050680 | 1.295 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.098357 | 1.007 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.154152 | 0.812 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.035225 | 1.453 |
| R-HSA-2142700 | Biosynthesis of Lipoxins (LX) | 0.155204 | 0.809 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.191600 | 0.718 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.032091 | 1.494 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.261378 | 0.583 |
| R-HSA-392499 | Metabolism of proteins | 0.239385 | 0.621 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.148087 | 0.829 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.040139 | 1.396 |
| R-HSA-68882 | Mitotic Anaphase | 0.096191 | 1.017 |
| R-HSA-9607240 | FLT3 Signaling | 0.296903 | 0.527 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.142715 | 0.846 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.097309 | 1.012 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.308919 | 0.510 |
| R-HSA-75153 | Apoptotic execution phase | 0.060132 | 1.221 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.185644 | 0.731 |
| R-HSA-2160916 | Hyaluronan degradation | 0.203383 | 0.692 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.114665 | 0.941 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.114665 | 0.941 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.029074 | 1.536 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.185644 | 0.731 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.191600 | 0.718 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.248836 | 0.604 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.114665 | 0.941 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.259792 | 0.585 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.131606 | 0.881 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.275929 | 0.559 |
| R-HSA-418346 | Platelet homeostasis | 0.214440 | 0.669 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.064070 | 1.193 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.254857 | 0.594 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.047065 | 1.327 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.259792 | 0.585 |
| R-HSA-162582 | Signal Transduction | 0.299865 | 0.523 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.259792 | 0.585 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.099741 | 1.001 |
| R-HSA-8964038 | LDL clearance | 0.185644 | 0.731 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.203383 | 0.692 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.203383 | 0.692 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.084966 | 1.071 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.219800 | 0.658 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.312238 | 0.506 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.023645 | 1.626 |
| R-HSA-8853659 | RET signaling | 0.270589 | 0.568 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.308989 | 0.510 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.222484 | 0.653 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.121855 | 0.914 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.078891 | 1.103 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.078891 | 1.103 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.254334 | 0.595 |
| R-HSA-6807070 | PTEN Regulation | 0.316984 | 0.499 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.233247 | 0.632 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.241341 | 0.617 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.147581 | 0.831 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.129151 | 0.889 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.129679 | 0.887 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.100644 | 0.997 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.286493 | 0.543 |
| R-HSA-1500931 | Cell-Cell communication | 0.233146 | 0.632 |
| R-HSA-201556 | Signaling by ALK | 0.286493 | 0.543 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.260270 | 0.585 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.126708 | 0.897 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.291717 | 0.535 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.156702 | 0.805 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.317275 | 0.499 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.317275 | 0.499 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.317275 | 0.499 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.317275 | 0.499 |
| R-HSA-774815 | Nucleosome assembly | 0.322276 | 0.492 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.322276 | 0.492 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.322276 | 0.492 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.322276 | 0.492 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.327241 | 0.485 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.327241 | 0.485 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.327241 | 0.485 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.327241 | 0.485 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.329454 | 0.482 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.332169 | 0.479 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.332169 | 0.479 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.332169 | 0.479 |
| R-HSA-449147 | Signaling by Interleukins | 0.336454 | 0.473 |
| R-HSA-9634597 | GPER1 signaling | 0.337062 | 0.472 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.337062 | 0.472 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.341919 | 0.466 |
| R-HSA-73893 | DNA Damage Bypass | 0.341919 | 0.466 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.341919 | 0.466 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.346741 | 0.460 |
| R-HSA-9748787 | Azathioprine ADME | 0.346741 | 0.460 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.351656 | 0.454 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.356280 | 0.448 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.356280 | 0.448 |
| R-HSA-73887 | Death Receptor Signaling | 0.359578 | 0.444 |
| R-HSA-1221632 | Meiotic synapsis | 0.360997 | 0.442 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.360997 | 0.442 |
| R-HSA-1989781 | PPARA activates gene expression | 0.362211 | 0.441 |
| R-HSA-72649 | Translation initiation complex formation | 0.365680 | 0.437 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.367465 | 0.435 |
| R-HSA-418597 | G alpha (z) signalling events | 0.370329 | 0.431 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.374945 | 0.426 |
| R-HSA-5578775 | Ion homeostasis | 0.374945 | 0.426 |
| R-HSA-75893 | TNF signaling | 0.374945 | 0.426 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.374945 | 0.426 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.374945 | 0.426 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.375316 | 0.426 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.376637 | 0.424 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.379527 | 0.421 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.384075 | 0.416 |
| R-HSA-9033241 | Peroxisomal protein import | 0.388591 | 0.411 |
| R-HSA-180786 | Extension of Telomeres | 0.388591 | 0.411 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.388591 | 0.411 |
| R-HSA-4085001 | Sialic acid metabolism | 0.388591 | 0.411 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.393073 | 0.406 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.393073 | 0.406 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.393073 | 0.406 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.393073 | 0.406 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.393073 | 0.406 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.393073 | 0.406 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.393073 | 0.406 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.395150 | 0.403 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.403750 | 0.394 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.406327 | 0.391 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.406955 | 0.390 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.408916 | 0.388 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.410680 | 0.386 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.410680 | 0.386 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.410680 | 0.386 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.411402 | 0.386 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.411402 | 0.386 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.419293 | 0.377 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.423552 | 0.373 |
| R-HSA-5218859 | Regulated Necrosis | 0.427781 | 0.369 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.436146 | 0.360 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.436146 | 0.360 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.444389 | 0.352 |
| R-HSA-74259 | Purine catabolism | 0.444389 | 0.352 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.448466 | 0.348 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.448914 | 0.348 |
| R-HSA-983712 | Ion channel transport | 0.451368 | 0.345 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.452513 | 0.344 |
| R-HSA-382551 | Transport of small molecules | 0.453781 | 0.343 |
| R-HSA-5617833 | Cilium Assembly | 0.453816 | 0.343 |
| R-HSA-9675108 | Nervous system development | 0.453917 | 0.343 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.456531 | 0.341 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.460519 | 0.337 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.468410 | 0.329 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.468410 | 0.329 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.468410 | 0.329 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.472312 | 0.326 |
| R-HSA-9833482 | PKR-mediated signaling | 0.476185 | 0.322 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.480031 | 0.319 |
| R-HSA-212436 | Generic Transcription Pathway | 0.486523 | 0.313 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.491400 | 0.309 |
| R-HSA-1500620 | Meiosis | 0.495135 | 0.305 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.495135 | 0.305 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.496551 | 0.304 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.497754 | 0.303 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.505706 | 0.296 |
| R-HSA-70268 | Pyruvate metabolism | 0.506176 | 0.296 |
| R-HSA-156902 | Peptide chain elongation | 0.509803 | 0.293 |
| R-HSA-9663891 | Selective autophagy | 0.509803 | 0.293 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.509803 | 0.293 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.520527 | 0.284 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.520527 | 0.284 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.524049 | 0.281 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.527546 | 0.278 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.527546 | 0.278 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.527546 | 0.278 |
| R-HSA-2029481 | FCGR activation | 0.531018 | 0.275 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.531018 | 0.275 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.534464 | 0.272 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.537885 | 0.269 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.537885 | 0.269 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.541281 | 0.267 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.541281 | 0.267 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.541281 | 0.267 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.544652 | 0.264 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.547999 | 0.261 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.551322 | 0.259 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.551322 | 0.259 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.551322 | 0.259 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.551322 | 0.259 |
| R-HSA-72312 | rRNA processing | 0.552833 | 0.257 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.554620 | 0.256 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.554620 | 0.256 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.555421 | 0.255 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.557894 | 0.253 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.561144 | 0.251 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.561144 | 0.251 |
| R-HSA-8939211 | ESR-mediated signaling | 0.563508 | 0.249 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.563508 | 0.249 |
| R-HSA-192823 | Viral mRNA Translation | 0.567574 | 0.246 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.567727 | 0.246 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.577043 | 0.239 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.580154 | 0.236 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.592371 | 0.227 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.598347 | 0.223 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.598347 | 0.223 |
| R-HSA-422475 | Axon guidance | 0.598676 | 0.223 |
| R-HSA-5688426 | Deubiquitination | 0.600428 | 0.222 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.604236 | 0.219 |
| R-HSA-74160 | Gene expression (Transcription) | 0.606436 | 0.217 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.607148 | 0.217 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.612909 | 0.213 |
| R-HSA-5693538 | Homology Directed Repair | 0.621394 | 0.207 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.624181 | 0.205 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.624181 | 0.205 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.625618 | 0.204 |
| R-HSA-3371556 | Cellular response to heat stress | 0.629694 | 0.201 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.635127 | 0.197 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.636827 | 0.196 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.637814 | 0.195 |
| R-HSA-5668914 | Diseases of metabolism | 0.640782 | 0.193 |
| R-HSA-72766 | Translation | 0.643773 | 0.191 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.645758 | 0.190 |
| R-HSA-114608 | Platelet degranulation | 0.648367 | 0.188 |
| R-HSA-69481 | G2/M Checkpoints | 0.648367 | 0.188 |
| R-HSA-9658195 | Leishmania infection | 0.649574 | 0.187 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.649574 | 0.187 |
| R-HSA-8956319 | Nucleotide catabolism | 0.653528 | 0.185 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.656080 | 0.183 |
| R-HSA-1474165 | Reproduction | 0.658614 | 0.181 |
| R-HSA-5576891 | Cardiac conduction | 0.661130 | 0.180 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.661130 | 0.180 |
| R-HSA-168249 | Innate Immune System | 0.664542 | 0.177 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.666105 | 0.176 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.680601 | 0.167 |
| R-HSA-9664407 | Parasite infection | 0.685293 | 0.164 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.685293 | 0.164 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.685293 | 0.164 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.692203 | 0.160 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.692203 | 0.160 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.694473 | 0.158 |
| R-HSA-597592 | Post-translational protein modification | 0.697207 | 0.157 |
| R-HSA-69242 | S Phase | 0.705575 | 0.151 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.714169 | 0.146 |
| R-HSA-2142753 | Arachidonate metabolism | 0.714169 | 0.146 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.714223 | 0.146 |
| R-HSA-9609507 | Protein localization | 0.716278 | 0.145 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.716278 | 0.145 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.718371 | 0.144 |
| R-HSA-8957322 | Metabolism of steroids | 0.720261 | 0.143 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.720450 | 0.142 |
| R-HSA-162587 | HIV Life Cycle | 0.724561 | 0.140 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.724561 | 0.140 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.726594 | 0.139 |
| R-HSA-877300 | Interferon gamma signaling | 0.728612 | 0.138 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.730616 | 0.136 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.738484 | 0.132 |
| R-HSA-5619102 | SLC transporter disorders | 0.744235 | 0.128 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.744745 | 0.128 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.753543 | 0.123 |
| R-HSA-418555 | G alpha (s) signalling events | 0.753543 | 0.123 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.757171 | 0.121 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.757171 | 0.121 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.757171 | 0.121 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.758965 | 0.120 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.760746 | 0.119 |
| R-HSA-611105 | Respiratory electron transport | 0.766012 | 0.116 |
| R-HSA-168255 | Influenza Infection | 0.767741 | 0.115 |
| R-HSA-73894 | DNA Repair | 0.769936 | 0.114 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.774533 | 0.111 |
| R-HSA-69275 | G2/M Transition | 0.779498 | 0.108 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.782747 | 0.106 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.790664 | 0.102 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.795276 | 0.099 |
| R-HSA-913531 | Interferon Signaling | 0.798668 | 0.098 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.801270 | 0.096 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.805650 | 0.094 |
| R-HSA-6805567 | Keratinization | 0.811342 | 0.091 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.813937 | 0.089 |
| R-HSA-418990 | Adherens junctions interactions | 0.827445 | 0.082 |
| R-HSA-9748784 | Drug ADME | 0.827445 | 0.082 |
| R-HSA-168256 | Immune System | 0.832307 | 0.080 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.837415 | 0.077 |
| R-HSA-162906 | HIV Infection | 0.838621 | 0.076 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.839817 | 0.076 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.842184 | 0.075 |
| R-HSA-109582 | Hemostasis | 0.846454 | 0.072 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.846814 | 0.072 |
| R-HSA-15869 | Metabolism of nucleotides | 0.849078 | 0.071 |
| R-HSA-157118 | Signaling by NOTCH | 0.853508 | 0.069 |
| R-HSA-1643685 | Disease | 0.857430 | 0.067 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.860951 | 0.065 |
| R-HSA-4839726 | Chromatin organization | 0.863008 | 0.064 |
| R-HSA-421270 | Cell-cell junction organization | 0.865035 | 0.063 |
| R-HSA-446728 | Cell junction organization | 0.889656 | 0.051 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.892903 | 0.049 |
| R-HSA-1280218 | Adaptive Immune System | 0.897550 | 0.047 |
| R-HSA-195721 | Signaling by WNT | 0.904970 | 0.043 |
| R-HSA-211859 | Biological oxidations | 0.911164 | 0.040 |
| R-HSA-1474244 | Extracellular matrix organization | 0.925765 | 0.033 |
| R-HSA-9679506 | SARS-CoV Infections | 0.926902 | 0.033 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.935134 | 0.029 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.942039 | 0.026 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.950124 | 0.022 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.950563 | 0.022 |
| R-HSA-418594 | G alpha (i) signalling events | 0.958362 | 0.018 |
| R-HSA-8978868 | Fatty acid metabolism | 0.958362 | 0.018 |
| R-HSA-199991 | Membrane Trafficking | 0.959089 | 0.018 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.962810 | 0.016 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.971005 | 0.013 |
| R-HSA-9824446 | Viral Infection Pathways | 0.972204 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 0.981872 | 0.008 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.985515 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 0.988580 | 0.005 |
| R-HSA-5663205 | Infectious disease | 0.989114 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.989550 | 0.005 |
| R-HSA-1266738 | Developmental Biology | 0.997304 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999806 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.871 | 0.473 | 1 | 0.856 |
CLK2 |
0.858 | 0.475 | -3 | 0.782 |
SRPK1 |
0.857 | 0.362 | -3 | 0.793 |
HIPK1 |
0.854 | 0.412 | 1 | 0.855 |
DYRK2 |
0.854 | 0.401 | 1 | 0.847 |
ICK |
0.854 | 0.333 | -3 | 0.854 |
CDKL1 |
0.854 | 0.255 | -3 | 0.827 |
CLK4 |
0.854 | 0.413 | -3 | 0.785 |
CLK1 |
0.852 | 0.416 | -3 | 0.768 |
PIM3 |
0.852 | 0.251 | -3 | 0.848 |
NLK |
0.852 | 0.277 | 1 | 0.880 |
CAMLCK |
0.851 | 0.272 | -2 | 0.906 |
HIPK4 |
0.849 | 0.356 | 1 | 0.852 |
HIPK2 |
0.849 | 0.411 | 1 | 0.782 |
PIM1 |
0.848 | 0.259 | -3 | 0.801 |
CAMK1B |
0.848 | 0.197 | -3 | 0.847 |
CDKL5 |
0.848 | 0.256 | -3 | 0.820 |
DAPK2 |
0.847 | 0.237 | -3 | 0.854 |
SKMLCK |
0.847 | 0.257 | -2 | 0.925 |
RSK2 |
0.847 | 0.296 | -3 | 0.796 |
COT |
0.846 | 0.118 | 2 | 0.766 |
MOS |
0.846 | 0.091 | 1 | 0.822 |
NIK |
0.844 | 0.139 | -3 | 0.849 |
JNK2 |
0.844 | 0.329 | 1 | 0.770 |
DYRK4 |
0.844 | 0.402 | 1 | 0.795 |
SRPK3 |
0.843 | 0.276 | -3 | 0.769 |
PRPK |
0.843 | -0.063 | -1 | 0.815 |
MAK |
0.843 | 0.403 | -2 | 0.816 |
SRPK2 |
0.843 | 0.313 | -3 | 0.727 |
DYRK3 |
0.842 | 0.403 | 1 | 0.859 |
HIPK3 |
0.842 | 0.371 | 1 | 0.832 |
WNK1 |
0.841 | 0.157 | -2 | 0.900 |
DYRK1A |
0.841 | 0.345 | 1 | 0.833 |
P90RSK |
0.840 | 0.244 | -3 | 0.805 |
BMPR2 |
0.840 | -0.106 | -2 | 0.859 |
P38A |
0.840 | 0.300 | 1 | 0.819 |
LATS1 |
0.840 | 0.183 | -3 | 0.840 |
ERK5 |
0.839 | 0.142 | 1 | 0.835 |
P70S6KB |
0.839 | 0.212 | -3 | 0.802 |
PKN3 |
0.839 | 0.118 | -3 | 0.840 |
CDK1 |
0.838 | 0.309 | 1 | 0.784 |
CDC7 |
0.838 | 0.065 | 1 | 0.794 |
RAF1 |
0.838 | -0.014 | 1 | 0.786 |
JNK3 |
0.838 | 0.291 | 1 | 0.790 |
DYRK1B |
0.838 | 0.355 | 1 | 0.796 |
AURC |
0.838 | 0.318 | -2 | 0.787 |
PKCD |
0.838 | 0.182 | 2 | 0.657 |
CDK5 |
0.837 | 0.295 | 1 | 0.810 |
P38B |
0.837 | 0.305 | 1 | 0.781 |
MST4 |
0.837 | 0.108 | 2 | 0.740 |
ATR |
0.837 | 0.001 | 1 | 0.757 |
RSK3 |
0.836 | 0.242 | -3 | 0.799 |
PIM2 |
0.836 | 0.244 | -3 | 0.772 |
RSK4 |
0.836 | 0.285 | -3 | 0.780 |
NUAK2 |
0.836 | 0.138 | -3 | 0.845 |
MTOR |
0.836 | 0.064 | 1 | 0.784 |
NDR1 |
0.835 | 0.173 | -3 | 0.829 |
NDR2 |
0.835 | 0.187 | -3 | 0.838 |
PKN2 |
0.835 | 0.151 | -3 | 0.829 |
PKACB |
0.835 | 0.316 | -2 | 0.804 |
PRKD2 |
0.834 | 0.235 | -3 | 0.796 |
PRKD1 |
0.834 | 0.196 | -3 | 0.842 |
CDK14 |
0.834 | 0.329 | 1 | 0.786 |
P38G |
0.834 | 0.291 | 1 | 0.724 |
PKR |
0.834 | 0.051 | 1 | 0.779 |
CDK18 |
0.834 | 0.312 | 1 | 0.755 |
AMPKA1 |
0.833 | 0.107 | -3 | 0.842 |
BMPR1B |
0.833 | 0.138 | 1 | 0.785 |
AURB |
0.832 | 0.270 | -2 | 0.788 |
AKT2 |
0.832 | 0.261 | -3 | 0.734 |
MSK1 |
0.832 | 0.282 | -3 | 0.781 |
MOK |
0.832 | 0.360 | 1 | 0.840 |
CDK10 |
0.832 | 0.355 | 1 | 0.772 |
CAMK2G |
0.832 | -0.027 | 2 | 0.720 |
PKACG |
0.832 | 0.235 | -2 | 0.838 |
PASK |
0.832 | 0.192 | -3 | 0.865 |
CDK7 |
0.832 | 0.272 | 1 | 0.804 |
CAMK2D |
0.832 | 0.108 | -3 | 0.835 |
CDK8 |
0.832 | 0.261 | 1 | 0.808 |
MAPKAPK3 |
0.831 | 0.160 | -3 | 0.796 |
SMMLCK |
0.831 | 0.222 | -3 | 0.823 |
CDK13 |
0.831 | 0.271 | 1 | 0.782 |
SGK3 |
0.831 | 0.234 | -3 | 0.787 |
ALK4 |
0.831 | 0.043 | -2 | 0.827 |
VRK2 |
0.831 | -0.022 | 1 | 0.846 |
TSSK2 |
0.831 | 0.103 | -5 | 0.850 |
CHAK2 |
0.831 | 0.019 | -1 | 0.815 |
CAMK2A |
0.830 | 0.187 | 2 | 0.725 |
MYLK4 |
0.830 | 0.233 | -2 | 0.866 |
CDK3 |
0.830 | 0.301 | 1 | 0.737 |
DLK |
0.830 | -0.060 | 1 | 0.801 |
PAK1 |
0.830 | 0.202 | -2 | 0.885 |
PKG2 |
0.829 | 0.264 | -2 | 0.793 |
DSTYK |
0.829 | -0.038 | 2 | 0.785 |
TSSK1 |
0.829 | 0.128 | -3 | 0.856 |
PDHK4 |
0.829 | -0.211 | 1 | 0.804 |
ERK1 |
0.829 | 0.273 | 1 | 0.768 |
CDK12 |
0.829 | 0.284 | 1 | 0.763 |
MSK2 |
0.828 | 0.219 | -3 | 0.783 |
CAMK2B |
0.828 | 0.141 | 2 | 0.713 |
PRP4 |
0.828 | 0.173 | -3 | 0.733 |
MAPKAPK2 |
0.828 | 0.191 | -3 | 0.763 |
PKCA |
0.828 | 0.155 | 2 | 0.600 |
TGFBR1 |
0.828 | 0.072 | -2 | 0.798 |
GRK5 |
0.828 | -0.083 | -3 | 0.799 |
RIPK3 |
0.828 | -0.001 | 3 | 0.703 |
PRKX |
0.828 | 0.320 | -3 | 0.716 |
DAPK3 |
0.827 | 0.235 | -3 | 0.811 |
TGFBR2 |
0.827 | 0.010 | -2 | 0.792 |
MARK4 |
0.827 | 0.033 | 4 | 0.776 |
AMPKA2 |
0.827 | 0.118 | -3 | 0.819 |
GRK1 |
0.827 | 0.101 | -2 | 0.755 |
PRKD3 |
0.827 | 0.182 | -3 | 0.779 |
MNK2 |
0.826 | 0.212 | -2 | 0.877 |
ANKRD3 |
0.826 | -0.120 | 1 | 0.796 |
CDK19 |
0.826 | 0.272 | 1 | 0.781 |
CDK17 |
0.826 | 0.276 | 1 | 0.722 |
LATS2 |
0.826 | 0.110 | -5 | 0.743 |
PDHK1 |
0.826 | -0.167 | 1 | 0.802 |
CDK16 |
0.825 | 0.293 | 1 | 0.730 |
GRK6 |
0.825 | -0.008 | 1 | 0.805 |
PAK3 |
0.825 | 0.168 | -2 | 0.872 |
NEK6 |
0.825 | -0.030 | -2 | 0.840 |
TBK1 |
0.824 | -0.096 | 1 | 0.686 |
MST3 |
0.824 | 0.070 | 2 | 0.723 |
CDK9 |
0.824 | 0.252 | 1 | 0.788 |
DMPK1 |
0.824 | 0.297 | -3 | 0.774 |
ALK2 |
0.824 | 0.059 | -2 | 0.796 |
PKCB |
0.824 | 0.115 | 2 | 0.610 |
MEK1 |
0.824 | -0.147 | 2 | 0.709 |
MLK1 |
0.824 | -0.116 | 2 | 0.685 |
GRK7 |
0.823 | 0.063 | 1 | 0.748 |
MNK1 |
0.823 | 0.199 | -2 | 0.877 |
MPSK1 |
0.823 | 0.122 | 1 | 0.743 |
AKT1 |
0.823 | 0.256 | -3 | 0.747 |
PKCG |
0.823 | 0.126 | 2 | 0.603 |
ERK2 |
0.822 | 0.220 | 1 | 0.787 |
ULK2 |
0.822 | -0.145 | 2 | 0.644 |
HUNK |
0.822 | -0.059 | 2 | 0.676 |
IKKB |
0.822 | -0.070 | -2 | 0.723 |
NEK9 |
0.822 | -0.140 | 2 | 0.708 |
CDK2 |
0.821 | 0.194 | 1 | 0.837 |
GAK |
0.821 | 0.063 | 1 | 0.793 |
NEK7 |
0.821 | -0.135 | -3 | 0.827 |
P38D |
0.821 | 0.281 | 1 | 0.718 |
RIPK1 |
0.821 | -0.076 | 1 | 0.745 |
MLK2 |
0.821 | -0.118 | 2 | 0.697 |
BRAF |
0.821 | -0.055 | -4 | 0.779 |
AURA |
0.821 | 0.230 | -2 | 0.765 |
PAK2 |
0.821 | 0.147 | -2 | 0.868 |
ROCK2 |
0.820 | 0.241 | -3 | 0.795 |
DCAMKL1 |
0.820 | 0.105 | -3 | 0.800 |
NEK2 |
0.820 | -0.021 | 2 | 0.684 |
CAMK4 |
0.820 | 0.066 | -3 | 0.808 |
DAPK1 |
0.820 | 0.223 | -3 | 0.801 |
PKACA |
0.820 | 0.279 | -2 | 0.759 |
YSK4 |
0.820 | -0.111 | 1 | 0.735 |
PKCH |
0.819 | 0.095 | 2 | 0.582 |
PKCZ |
0.819 | 0.088 | 2 | 0.650 |
PAK6 |
0.819 | 0.245 | -2 | 0.805 |
NEK5 |
0.819 | -0.061 | 1 | 0.742 |
IKKE |
0.819 | -0.116 | 1 | 0.690 |
QSK |
0.819 | 0.089 | 4 | 0.756 |
MASTL |
0.818 | -0.241 | -2 | 0.800 |
MLK3 |
0.818 | -0.025 | 2 | 0.614 |
CDK4 |
0.818 | 0.284 | 1 | 0.757 |
CDK6 |
0.818 | 0.274 | 1 | 0.764 |
MELK |
0.818 | 0.064 | -3 | 0.805 |
WNK3 |
0.818 | -0.149 | 1 | 0.742 |
ACVR2A |
0.818 | -0.006 | -2 | 0.771 |
WNK4 |
0.818 | 0.011 | -2 | 0.887 |
SGK1 |
0.818 | 0.244 | -3 | 0.670 |
ACVR2B |
0.817 | 0.002 | -2 | 0.784 |
PLK1 |
0.817 | -0.085 | -2 | 0.784 |
CHK1 |
0.817 | 0.042 | -3 | 0.805 |
IRE1 |
0.817 | -0.021 | 1 | 0.727 |
MRCKB |
0.817 | 0.241 | -3 | 0.756 |
TAO3 |
0.817 | -0.020 | 1 | 0.759 |
TNIK |
0.817 | 0.076 | 3 | 0.845 |
KIS |
0.816 | 0.240 | 1 | 0.821 |
MEK5 |
0.816 | -0.184 | 2 | 0.690 |
BUB1 |
0.816 | 0.220 | -5 | 0.818 |
MRCKA |
0.816 | 0.221 | -3 | 0.764 |
GCK |
0.815 | 0.035 | 1 | 0.747 |
IRE2 |
0.815 | -0.016 | 2 | 0.609 |
MEKK2 |
0.815 | -0.130 | 2 | 0.670 |
LKB1 |
0.815 | 0.004 | -3 | 0.815 |
EEF2K |
0.814 | 0.036 | 3 | 0.812 |
CAMK1D |
0.814 | 0.160 | -3 | 0.725 |
MEKK1 |
0.814 | -0.136 | 1 | 0.771 |
CAMK1G |
0.814 | 0.119 | -3 | 0.783 |
PKCE |
0.814 | 0.182 | 2 | 0.589 |
BMPR1A |
0.814 | 0.082 | 1 | 0.768 |
AKT3 |
0.814 | 0.262 | -3 | 0.692 |
DNAPK |
0.813 | 0.007 | 1 | 0.619 |
JNK1 |
0.813 | 0.227 | 1 | 0.761 |
TAO2 |
0.813 | -0.048 | 2 | 0.718 |
QIK |
0.813 | -0.016 | -3 | 0.826 |
ZAK |
0.813 | -0.114 | 1 | 0.768 |
ERK7 |
0.813 | 0.099 | 2 | 0.476 |
GCN2 |
0.813 | -0.206 | 2 | 0.677 |
NIM1 |
0.813 | -0.041 | 3 | 0.754 |
KHS1 |
0.812 | 0.080 | 1 | 0.727 |
CHAK1 |
0.812 | -0.083 | 2 | 0.650 |
GSK3A |
0.812 | 0.128 | 4 | 0.483 |
HGK |
0.812 | 0.011 | 3 | 0.842 |
ATM |
0.812 | -0.059 | 1 | 0.689 |
MLK4 |
0.812 | -0.077 | 2 | 0.595 |
SIK |
0.811 | 0.077 | -3 | 0.773 |
P70S6K |
0.811 | 0.153 | -3 | 0.738 |
HPK1 |
0.811 | 0.041 | 1 | 0.737 |
MARK3 |
0.811 | 0.050 | 4 | 0.707 |
NUAK1 |
0.811 | 0.040 | -3 | 0.796 |
KHS2 |
0.810 | 0.091 | 1 | 0.737 |
HRI |
0.810 | -0.157 | -2 | 0.830 |
DRAK1 |
0.810 | -0.004 | 1 | 0.702 |
PKCT |
0.810 | 0.117 | 2 | 0.593 |
CAMKK2 |
0.810 | -0.073 | -2 | 0.713 |
NEK1 |
0.810 | -0.025 | 1 | 0.728 |
LRRK2 |
0.810 | -0.039 | 2 | 0.715 |
PKCI |
0.810 | 0.124 | 2 | 0.612 |
ULK1 |
0.810 | -0.180 | -3 | 0.781 |
CHK2 |
0.809 | 0.164 | -3 | 0.686 |
BCKDK |
0.809 | -0.144 | -1 | 0.702 |
TLK2 |
0.809 | -0.120 | 1 | 0.724 |
MEKK6 |
0.809 | -0.038 | 1 | 0.753 |
PHKG1 |
0.809 | 0.023 | -3 | 0.822 |
GSK3B |
0.809 | 0.068 | 4 | 0.477 |
IRAK4 |
0.809 | -0.045 | 1 | 0.723 |
PDK1 |
0.809 | -0.050 | 1 | 0.720 |
NEK4 |
0.809 | -0.071 | 1 | 0.722 |
IKKA |
0.809 | -0.062 | -2 | 0.707 |
DCAMKL2 |
0.809 | 0.027 | -3 | 0.809 |
HASPIN |
0.808 | 0.150 | -1 | 0.736 |
GRK2 |
0.808 | -0.043 | -2 | 0.712 |
PERK |
0.808 | -0.160 | -2 | 0.794 |
MEKK3 |
0.808 | -0.184 | 1 | 0.770 |
SSTK |
0.808 | 0.059 | 4 | 0.748 |
MINK |
0.808 | -0.045 | 1 | 0.735 |
ROCK1 |
0.807 | 0.225 | -3 | 0.764 |
CAMKK1 |
0.807 | -0.140 | -2 | 0.705 |
NEK8 |
0.807 | -0.132 | 2 | 0.684 |
MAP3K15 |
0.807 | -0.062 | 1 | 0.740 |
CRIK |
0.807 | 0.224 | -3 | 0.750 |
PINK1 |
0.807 | -0.079 | 1 | 0.809 |
GRK4 |
0.807 | -0.146 | -2 | 0.800 |
PLK3 |
0.807 | -0.098 | 2 | 0.661 |
NEK11 |
0.806 | -0.151 | 1 | 0.742 |
VRK1 |
0.806 | -0.082 | 2 | 0.710 |
SBK |
0.806 | 0.206 | -3 | 0.636 |
TTBK2 |
0.806 | -0.204 | 2 | 0.571 |
MARK2 |
0.806 | -0.007 | 4 | 0.663 |
LOK |
0.805 | 0.010 | -2 | 0.771 |
TLK1 |
0.805 | -0.130 | -2 | 0.815 |
BRSK1 |
0.805 | 0.052 | -3 | 0.808 |
MAPKAPK5 |
0.805 | 0.040 | -3 | 0.764 |
MST2 |
0.804 | -0.124 | 1 | 0.761 |
MARK1 |
0.804 | 0.002 | 4 | 0.729 |
PBK |
0.803 | 0.031 | 1 | 0.710 |
TAK1 |
0.803 | -0.116 | 1 | 0.744 |
CAMK1A |
0.803 | 0.168 | -3 | 0.702 |
SMG1 |
0.803 | -0.107 | 1 | 0.700 |
MST1 |
0.802 | -0.101 | 1 | 0.741 |
YSK1 |
0.801 | -0.041 | 2 | 0.685 |
PAK5 |
0.800 | 0.195 | -2 | 0.766 |
FAM20C |
0.799 | 0.018 | 2 | 0.548 |
BRSK2 |
0.799 | -0.026 | -3 | 0.809 |
BIKE |
0.798 | 0.041 | 1 | 0.685 |
SNRK |
0.797 | -0.105 | 2 | 0.543 |
PKN1 |
0.797 | 0.108 | -3 | 0.755 |
SLK |
0.796 | -0.046 | -2 | 0.714 |
PAK4 |
0.795 | 0.206 | -2 | 0.773 |
MYO3B |
0.795 | 0.011 | 2 | 0.698 |
PHKG2 |
0.794 | 0.032 | -3 | 0.787 |
PDHK3_TYR |
0.794 | 0.259 | 4 | 0.880 |
ASK1 |
0.794 | -0.087 | 1 | 0.734 |
TTK |
0.793 | -0.070 | -2 | 0.808 |
OSR1 |
0.792 | -0.080 | 2 | 0.669 |
MEK2 |
0.792 | -0.243 | 2 | 0.673 |
PLK4 |
0.790 | -0.182 | 2 | 0.474 |
AAK1 |
0.790 | 0.093 | 1 | 0.595 |
GRK3 |
0.790 | -0.047 | -2 | 0.675 |
IRAK1 |
0.789 | -0.252 | -1 | 0.689 |
CK1E |
0.788 | -0.045 | -3 | 0.520 |
NEK3 |
0.788 | -0.115 | 1 | 0.711 |
CK1D |
0.787 | -0.038 | -3 | 0.471 |
MYO3A |
0.787 | -0.067 | 1 | 0.732 |
STK33 |
0.787 | -0.102 | 2 | 0.478 |
TESK1_TYR |
0.787 | 0.103 | 3 | 0.843 |
CK2A2 |
0.786 | 0.022 | 1 | 0.679 |
PKG1 |
0.786 | 0.194 | -2 | 0.722 |
CK1A2 |
0.786 | -0.033 | -3 | 0.476 |
PLK2 |
0.785 | -0.065 | -3 | 0.730 |
PKMYT1_TYR |
0.785 | 0.081 | 3 | 0.811 |
LIMK2_TYR |
0.785 | 0.155 | -3 | 0.849 |
PDHK4_TYR |
0.784 | 0.112 | 2 | 0.780 |
TAO1 |
0.784 | -0.080 | 1 | 0.687 |
MAP2K4_TYR |
0.783 | 0.045 | -1 | 0.819 |
ALPHAK3 |
0.782 | -0.097 | -1 | 0.744 |
MAP2K6_TYR |
0.781 | 0.040 | -1 | 0.819 |
BMPR2_TYR |
0.781 | 0.049 | -1 | 0.819 |
RIPK2 |
0.781 | -0.225 | 1 | 0.709 |
TTBK1 |
0.780 | -0.207 | 2 | 0.491 |
MAP2K7_TYR |
0.779 | -0.084 | 2 | 0.736 |
PDHK1_TYR |
0.778 | -0.018 | -1 | 0.836 |
EPHA6 |
0.777 | 0.055 | -1 | 0.803 |
PINK1_TYR |
0.776 | -0.087 | 1 | 0.792 |
CK2A1 |
0.776 | 0.007 | 1 | 0.661 |
RET |
0.776 | -0.009 | 1 | 0.767 |
EPHB4 |
0.772 | 0.011 | -1 | 0.772 |
LIMK1_TYR |
0.772 | -0.085 | 2 | 0.719 |
MST1R |
0.771 | -0.072 | 3 | 0.769 |
YANK3 |
0.770 | -0.068 | 2 | 0.316 |
STLK3 |
0.770 | -0.236 | 1 | 0.729 |
ABL2 |
0.770 | -0.004 | -1 | 0.769 |
TXK |
0.768 | 0.053 | 1 | 0.797 |
TYRO3 |
0.768 | -0.109 | 3 | 0.770 |
ROS1 |
0.768 | -0.108 | 3 | 0.739 |
JAK2 |
0.767 | -0.106 | 1 | 0.765 |
TYK2 |
0.767 | -0.164 | 1 | 0.758 |
YES1 |
0.766 | -0.044 | -1 | 0.806 |
CSF1R |
0.766 | -0.081 | 3 | 0.760 |
TNK2 |
0.766 | -0.001 | 3 | 0.717 |
TNNI3K_TYR |
0.766 | 0.054 | 1 | 0.798 |
DDR1 |
0.765 | -0.089 | 4 | 0.788 |
JAK3 |
0.765 | -0.078 | 1 | 0.745 |
CK1G1 |
0.765 | -0.096 | -3 | 0.506 |
ABL1 |
0.765 | -0.034 | -1 | 0.762 |
FGR |
0.765 | -0.084 | 1 | 0.786 |
TNK1 |
0.765 | 0.016 | 3 | 0.749 |
EPHA4 |
0.765 | -0.013 | 2 | 0.674 |
LCK |
0.763 | -0.009 | -1 | 0.784 |
KDR |
0.761 | -0.054 | 3 | 0.707 |
ITK |
0.761 | -0.033 | -1 | 0.729 |
EPHB1 |
0.761 | -0.055 | 1 | 0.812 |
FGFR2 |
0.760 | -0.090 | 3 | 0.737 |
SRMS |
0.760 | -0.057 | 1 | 0.807 |
BLK |
0.760 | -0.000 | -1 | 0.789 |
JAK1 |
0.760 | -0.048 | 1 | 0.711 |
KIT |
0.760 | -0.094 | 3 | 0.761 |
FER |
0.759 | -0.155 | 1 | 0.808 |
BMX |
0.759 | -0.011 | -1 | 0.684 |
INSRR |
0.759 | -0.131 | 3 | 0.704 |
EPHB3 |
0.759 | -0.067 | -1 | 0.746 |
HCK |
0.759 | -0.104 | -1 | 0.773 |
NEK10_TYR |
0.758 | -0.074 | 1 | 0.622 |
DDR2 |
0.758 | 0.074 | 3 | 0.686 |
PDGFRB |
0.758 | -0.146 | 3 | 0.768 |
EPHB2 |
0.758 | -0.053 | -1 | 0.754 |
TEK |
0.757 | -0.100 | 3 | 0.702 |
MET |
0.755 | -0.090 | 3 | 0.745 |
MERTK |
0.755 | -0.092 | 3 | 0.725 |
FLT3 |
0.755 | -0.159 | 3 | 0.766 |
WEE1_TYR |
0.755 | -0.041 | -1 | 0.694 |
AXL |
0.755 | -0.122 | 3 | 0.730 |
TEC |
0.755 | -0.067 | -1 | 0.675 |
EPHA7 |
0.754 | -0.041 | 2 | 0.658 |
FGFR1 |
0.754 | -0.145 | 3 | 0.714 |
FYN |
0.753 | -0.020 | -1 | 0.770 |
ALK |
0.750 | -0.146 | 3 | 0.679 |
FLT1 |
0.750 | -0.094 | -1 | 0.777 |
LTK |
0.750 | -0.132 | 3 | 0.690 |
PTK2B |
0.750 | -0.031 | -1 | 0.730 |
EPHA1 |
0.749 | -0.090 | 3 | 0.716 |
PDGFRA |
0.749 | -0.226 | 3 | 0.772 |
EPHA3 |
0.748 | -0.120 | 2 | 0.639 |
MATK |
0.747 | -0.091 | -1 | 0.720 |
FGFR3 |
0.747 | -0.135 | 3 | 0.708 |
BTK |
0.746 | -0.215 | -1 | 0.686 |
FRK |
0.746 | -0.120 | -1 | 0.774 |
ERBB2 |
0.746 | -0.173 | 1 | 0.741 |
LYN |
0.745 | -0.114 | 3 | 0.687 |
EPHA5 |
0.744 | -0.071 | 2 | 0.654 |
NTRK1 |
0.744 | -0.225 | -1 | 0.754 |
PTK6 |
0.744 | -0.240 | -1 | 0.675 |
FLT4 |
0.743 | -0.177 | 3 | 0.696 |
INSR |
0.742 | -0.198 | 3 | 0.687 |
EPHA8 |
0.742 | -0.094 | -1 | 0.740 |
NTRK3 |
0.742 | -0.152 | -1 | 0.714 |
PTK2 |
0.742 | -0.010 | -1 | 0.740 |
SRC |
0.741 | -0.100 | -1 | 0.772 |
NTRK2 |
0.741 | -0.243 | 3 | 0.714 |
EGFR |
0.740 | -0.098 | 1 | 0.671 |
CSK |
0.740 | -0.146 | 2 | 0.662 |
YANK2 |
0.738 | -0.123 | 2 | 0.327 |
FGFR4 |
0.736 | -0.118 | -1 | 0.736 |
SYK |
0.736 | -0.040 | -1 | 0.730 |
EPHA2 |
0.734 | -0.073 | -1 | 0.714 |
CK1A |
0.731 | -0.092 | -3 | 0.386 |
ERBB4 |
0.729 | -0.082 | 1 | 0.691 |
IGF1R |
0.728 | -0.178 | 3 | 0.629 |
MUSK |
0.728 | -0.161 | 1 | 0.648 |
CK1G3 |
0.725 | -0.108 | -3 | 0.348 |
ZAP70 |
0.717 | -0.052 | -1 | 0.675 |
FES |
0.715 | -0.169 | -1 | 0.665 |
CK1G2 |
0.706 | -0.113 | -3 | 0.432 |